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Academic literature on the topic 'Bioactive'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 July 2024

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Journal articles on the topic "Bioactive"

Ouma, Stephen, Richard Kagia, and Faith Kamakia. "Determination of pharmacological activity of bioactives in Allium sativum using computational analysis." F1000Research 12 (February 9, 2023): 151. http://dx.doi.org/10.12688/f1000research.130105.1.

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Introduction: Use of natural products for management of diseases has increased widely due to the belief that natural products are less toxic than conventional medicines. Natural products have been utilised for management of chronic diseases such as diabetes and cancers. Respiratory infections have also been managed using natural products. Allium sativum is one of the natural products that has been utilised in the management of SARS-CoV infections, diabetes and cancer. Methods: This study was aimed at screening bioactive agents in Allium sativum using computational analysis. The targets of the bioactive agents were predicted using SwissTargetPrediction tools. Molecular docking followed, where the docking energies of the bioactive agents to the targets were generated. The bioactive agents were analysed for pharmacokinetics properties using SwissADME as well as toxicity profiles using the ProTox II webserver. The docking scores, toxicities and pharmacokinetics profiles of the bioactive agents in Allium sativum were compared with those of reference compounds. Results: All the bioactives showed lower docking scores than the reference compounds. The bioactives, however, showed some activity on specific receptors such as carbonic anhydrases, cyclooxygenase and ghrelin. All the bioactives showed high gastrointestinal tract absorption and none violated Lipinski’s rule of five. Diallyl trisulphide was predicted to be most lethal, with an LD50 of 100mg/kg, while was the safest, with 8000mg/kg. Conclusions: In conclusion, bioactives showed lower docking scores than the reference compounds, therefore overall pharmacological activity could be attributed to synergy between the bioactives for a particular receptor.

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Postružnik, Vesna, Slađana Stajčić, Dragana Borjan, Gordana Ćetković, Željko Knez, Maša Knez Marevci, and Jelena Vulić. "Impact of Storage Conditions on Stability of Bioactive Compounds and Bioactivity of Beetroot Extract and Encapsulates." Processes 12, no. 7 (June 28, 2024): 1345. http://dx.doi.org/10.3390/pr12071345.

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(1) Background: In this study, bioactive compounds (phenolics and betalains) extracted from beetroot were stabilized by encapsulation with maltodextrin and soy protein by the freeze drying method. Stability of bioactive compounds and bioactivities in a beetroot extract and encapsulates during 60 days of storage at 4 °C (without light) and at 25 °C (with and without light) were investigated. (2) Methods: Contents of bioactive compounds and bioactivity (antioxidant activity by DPPH, RP, and ABTS tests; anti-inflammatory and antihyperglycemic activity) were determined. Improvement in stability of bioactives’ content and bioactivity of prepared encapsulates in relation to the extract was observed after storage at room temperature under light conditions. (3) Results: Encapsulation with maltodextrin showed improvement in stability of all studied bioactive parameters, while an encapsulate with soy protein improved stability of bioactives and antioxidant activity compared to the extract. The encapsulated beetroot extract represents a promising food additive for functional foods due to their content of bioactive compounds and consequent bioactivities.

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Yates, Allison A., Johanna T. Dwyer, John W. Erdman, Janet C. King, Barbara J. Lyle, Barbara O. Schneeman, and Connie M. Weaver. "Perspective: Framework for Developing Recommended Intakes of Bioactive Dietary Substances." Advances in Nutrition 12, no. 4 (May 7, 2021): 1087–99. http://dx.doi.org/10.1093/advances/nmab044.

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ABSTRACT Dietary bioactives are food substances that promote health but are not essential to prevent typical deficiency conditions. Examples include lutein and zeaxanthin, omega-3 fatty acids, and flavonoids. When quality evidence is available, quantified intake recommendations linking dietary bioactives with specific health benefits will enable health professionals to provide evidence-based information to consumers. Without evidence-based recommendations, consumers use information from available sources that often lack standards and rigor. This article describes a framework to develop guidance based on quality evidence fully vetted for efficacy and safety by qualified experts, and designed to communicate the amounts of specific dietary bioactive compounds with identified health benefits. The 4-step Framework described here can be adapted by credible health organizations to work within their guideline development process. Standards of practice used in clinical guidelines are adapted to quantify dietary bioactive intake recommendations from foods consumed by the general public, by taking into account that side effects and trade-offs are often needed for medical treatments but are not acceptable for dietary bioactives. In quantifying dietary bioactive recommendations, this Framework establishes 4 decision-making steps: 1) characterize the bioactive, determine amounts in specific food sources, and quantify intakes; 2) evaluate safety; 3) quantify the causal relation between the specific bioactive and accepted markers of health or normal function via systematic evidence reviews; and 4) translate the evidence into a quantified bioactive intake statement. This Framework provides a working model that can be updated as new approaches are advanced.

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Evans, Levi W., Samantha S. Romanick, and Bradley S. Ferguson. "Natural product inhibitors of acetyl-lysine erasers in the prevention and treatment of heart failure." Functional Foods in Health and Disease 7, no. 8 (August 31, 2017): 577. http://dx.doi.org/10.31989/ffhd.v7i8.376.

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Background: Heart failure (HF) is a major public health concern, with five-year mortality rates following first admission for HF being approximately 50%, thereby stressing the need for novel therapeutic approaches. Histone deacetylases (HDACs) govern lysine acetylation of histone tails that regulates nucleosmal DNA. HDAC inhibitors have emerged as efficacious therapies in pre-clinical models of HF. Interest in diet-gene interactions has given rise to the study of ‘food bioactives’ as epigenetic regulators of gene expression that control human health and disease. These reports demonstrate that bioactive food compounds regulate epigenetic marks that link diet to gene regulation. In fact, others have also shown that bioactive compounds can target HDACs for inhibition; accordingly, bioactive food compounds offer unique opportunities for therapeutic intervention and prevention of heart failure. Lastly, there is emerging interest into how these food bioactives function together or as additives within foods ‘functional foods’ to regulate epigenetic disease. This review will highlight bioactive compound HDAC inhibitors and their role in the heart.Keywords: acetylation, bioactive compounds, dietary HDAC inhibitors, HDACs, histone deacetylases

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Ramadan, Mohamed Fawzy, Alessandra Durazzo, and Massimo Lucarini. "Advances in Research on Food Bioactive Molecules and Health." Molecules 26, no. 24 (December 19, 2021): 7678. http://dx.doi.org/10.3390/molecules26247678.

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Fresh and processed food products are rich in bioactive molecules, including polysaccharides, vitamins, carotenoids, peptides, antioxidants, phenolics, phytosterols, and novel lipids. Bioactive molecules in food could prevent several diseases (i.e., metabolic syndrome, cardiovascular diseases, cancer, etc.). Thus, consumer awareness is growing about the health-promoting impact of food bioactive molecules. Health claims are essential added-value features, wherein health-enhancing potential of bioactives depend on their chemical structure. On the other hand, the investigation of the structure-function relationship of food bioactive molecules is of importance. In this regard, Molecules is delighted to highlight the importance of food bioactive molecules and their effect on health. In this Special Issue of Molecules, researchers are invited to contribute original research and up-to-date reviews.

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Bordoni, A., C. Boesch, C. Malpuech-Brugère, C. Orfila, and L. Tomás-Cobos. "The role of bioactives in energy metabolism and metabolic syndrome." Proceedings of the Nutrition Society 78, no. 3 (April 10, 2019): 340–50. http://dx.doi.org/10.1017/s0029665119000545.

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Some food bioactives potentially exert anti-obesity effects. Anthocyanins (ACN), catechins, β-glucan (BG) and n-3 long chain PUFA (LCPUFA) are among the most promising candidates and have been considered as a strategy for the development of functional foods counteracting body weight gain. At present, clinical trials, reviews and meta-analyses addressing anti-obesity effects of various bioactives or bioactive-rich foods show contradictory results. Abdominal obesity is an important criterion for metabolic syndrome (MetS) diagnosis along with glucose intolerance, dyslipidaemia and hypertension. Food bioactives are supposed to exert beneficial effects on these parameters, therefore representing alternative therapy approaches for the treatment of MetS. This review summarises outcomes on MetS biomarkers in recent clinical trials supplementing ACN, catechins, BG and n-3 LCPUFA, focusing mainly on anti-obesity effects. Overall, it is clear that the level of evidence for the effectiveness varies not only among the different bioactives but also among the different putative health benefits suggested for the same bioactive. Limited evidence may be due to the low number of controlled intervention trials or to inconsistencies in trial design, i.e. duration, dose and/or the method of bioactive supplementation (extracts, supplements, rich or enriched food). At present, the question ‘Are bioactives effective in weight management and prevention of metabolic syndrome?’ remains inconclusive. Thus, a common effort to harmonise the study design of intervention trials focusing on the most promising bioactive molecules is urgently needed to strengthen the evidence of their potential in the treatment of obesity, MetS and related diseases.

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Cecchi, Nicola, Roberta Romanelli, Flavia Ricevuti, Maria Grazia Carbone, Michele Dinardo, Elisabetta Cesarano, Alfredo De Michele, et al. "Bioactives in Oral Nutritional Supplementation: A Pediatric Point of View." Nutrients 16, no. 13 (June 28, 2024): 2067. http://dx.doi.org/10.3390/nu16132067.

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Background: Oral nutritional supplements (ONSs) are crucial for supporting the nutritional needs of pediatric populations, particularly those with medical conditions or dietary deficiencies. Bioactive compounds within ONSs play a pivotal role in enhancing health outcomes by exerting various physiological effects beyond basic nutrition. However, the comprehensive understanding of these bioactives in pediatric ONSs remains elusive. Objective: This systematic narrative review aims to critically evaluate the existing literature concerning bioactive compounds present in oral nutritional supplements from a pediatric standpoint, focusing on their types, sources, bioavailability, physiological effects, and clinical implications. Methods: A systematic search was conducted across the major academic databases, including PubMed, Scopus, and Web of Science, employing predefined search terms related to oral nutritional supplements, bioactives, and pediatrics. Studies published between 2013 and 2024 were considered eligible for inclusion. Data extraction and synthesis were performed according to the PRISMA guidelines. Results: The initial search yielded 558 of articles, of which 72 met the inclusion criteria. The included studies encompassed a diverse range of bioactive compounds present in pediatric ONS formulations, including, but not limited to, vitamins, minerals, amino acids, prebiotics, probiotics, and phytonutrients. These bioactives were sourced from various natural and synthetic origins and were found to exert beneficial effects on growth, development, immune function, gastrointestinal health, cognitive function, and overall well-being in pediatric populations. However, variations in bioavailability, dosing, and clinical efficacy were noted across different compounds and formulations. Conclusions: Bioactive compounds in oral nutritional supplements offer promising avenues for addressing the unique nutritional requirements and health challenges faced by pediatric populations. However, further research is warranted to elucidate the optimal composition, dosage, and clinical applications of these bioactives in pediatric ONS formulations. A deeper understanding of these bioactive compounds and their interplay with pediatric health may pave the way for personalized and effective nutritional interventions in pediatric clinical practice.

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K B S, Sushma. "Bioactive Glass: A Review." International Journal of Science and Research (IJSR) 12, no. 6 (June 5, 2023): 1645–49. http://dx.doi.org/10.21275/sr23612165802.

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Günal-Köroğlu, Deniz, Aysenur Betul Bilgin, Gulsah Karabulut, Beyza Saricaoglu, and Esra Capanoglu. "Encapsulation of hydrophobic compounds in yeast cells: methods, characterization, and applications." Exploration of Foods and Foodomics 2, no. 3 (June 20, 2024): 252–74. http://dx.doi.org/10.37349/eff.2024.00037.

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Encapsulation is a pivotal technique for protecting and enhancing the efficiency of sensitive natural bioactive substances, notably essential oils, vitamins, and phenolic compounds, widely used in foods and nutraceuticals. Critical considerations in selecting encapsulation agents encompass safety, release kinetics, stability, and cost-effectiveness. Yeast cells emerge as versatile carriers distinguished by their low cost, compatibility with biological systems, and eco-friendly degradation properties, accommodating both hydrophilic and hydrophobic bioactive agents. Various yeast strains, including Saccharomyces cerevisiae, Torulopsis lipofera, Cutaneotrichosporon curvatus, Yarrowia lipolytica, and Candida utilis, find utility in microencapsulation. Yeast cell encapsulation relies on the permeation of bioactive agents through yeast cell walls, predominantly composed of mannoproteins and polysaccharides. The encapsulation process includes passive or vacuum-infused diffusion of bioactive compounds inside yeast cells, precise droplet size control, and attractive forces to trap bioactive components within cellular structures. Yeast cells display versatility in various states, whether alive or dead, intact or plasmolyzed. In addition, the loading capacity of hydrophobic bioactives can be increased through chemical pretreatment techniques such as plasmolysis, autolysis, and enzyme hydrolysis, freeing up space within yeast cells by eliminating water-soluble components. In summary, yeast cell encapsulation presents a promising and sustainable technology with diverse applications within the food industry. Yeast cells enhance the stability and controlled release of bioactive compounds, magnifying the efficacy of natural hydrophobic bioactives like curcumin, essential oils, β-carotene, and vitamin D across various food products. This comprehensive review focuses on the encapsulation procedures, influential factors, characterization techniques, and applications, with a pronounced emphasis on hydrophobic materials.

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Donsì, Francesco, and Giovanna Ferrari. "Changing the Vision in Smart Food Design Utilizing the Next Generation of Nanometric Delivery Systems for Bioactive Compounds." Foods 9, no. 8 (August 12, 2020): 1100. http://dx.doi.org/10.3390/foods9081100.

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In modern foods, the delivery systems for bioactive compounds play a fundamental role in health promotion, wellbeing, and disease prevention through diet. Nanotechnology has secured a fundamental role in the fabrication of delivery systems with the capability of modulating the in-product and in-body behavior for augmenting bioavailability and activity of bioactive compounds. Structured nanoemulsions and nanoparticles, liposomes, and niosomes can be designed to improve bioactives preservation after ingestion, mucoadhesion, as well as of their release and pathophysiological relevance. In the future, it is expected that the delivery systems will also contribute to augment the efficacy of the bioactive compounds, for example by improving the intestinal absorption and delivery in the bloodstream, as well as promoting the formation of additional bioactive metabolites by regulating the transformations taking place during digestion and the interaction with the intestinal microbiota.

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Dissertations / Theses on the topic "Bioactive"

Wilcox, Matthew David. "Bioactive alginates." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578262.

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Alginates are polysaccharides extracted from the cell walls of brown seaweed or from certain bacteria such as Azotobacter vinelandii. Alginates have been shown to reduce the activity of pepsin and initial data suggest that it may affect the activity of pancreatic lipase. Pancreatic lipase plays an important role in the breakdown of triacylglycerol, if the activity of pancreatic lipase can be reduced then the breakdown of triacylglycerol would be reduce which in turn would lower the amount absorbed by the body. A pharmaceutical treatment for obesity called orlistat inhibits lipase and accounts for 66% of all prescriptions for treatments for obesity in 2008 in the UK. However the side effects of orlistat (uncontrolled diarrhoea and steatorrhea) can reduce the compliance with the treatment. If orlistat is taken with a high fibre product it has been shown that this can greatly reduce or eliminate the side effects. Since alginate is a dietary fibre it is believed that this could be an effect treatment for obesity. Colourimetric and turbidimetric assays were used to determine the effect of a wide range of alginates and other dietary fibres on pancreatic lipase. Alginates have the ability to inhibit pancreatic lipase, with a maximum inhibition of 72.2% (±9.9). Pectin could also inhibit lipase by a maximum of 71.8% (±22.3), however, specific enzymactically modified alginates could activate the enzyme by up to 22.0% (±10.1). Carrageenan and Hydroxypropyl methylcellulose could also activate the enzyme by a maximum of 37.3% (±24.5). The structure of the alginate is key to the inhibition or activation of the enzyme. Consecutive guluronate residues are important for inhibition whereas alternating mannuronate and guluronate blocks are detrimental to inhibition. The alginate that activated the enzyme was almost entirely consisting of poly-alternating uronate residues. The level of esterification was important for pectins inhibition of lipase with higher levels causing little inhibition. Alginate causes sustained inhibition at low concentrations of biopolymer compared to pectin. Therefore alginate could play a potential role in the management of obesity. ii

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Woods, Katherine B. "Bioactive natural products." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/26234.

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Montbretins A-E were isolated from the corms of Crocosmia sp., an invasive perennial plant. The montbretins are inhibitors of human pancreatic α-amylase (HPA). Montbretin A (2- 30) is a competitive inhibitor of HPA with a K₁ of 1.3 nM. The activity of the other family members varied significantly and provided structure-activity information. Saturation Transfer Difference (STD) NMR spectroscopy was used to determine that the caffeic acid region of the montbretins is important for binding. HPA is involved in the breakdown of complex carbohydrates; inhibition of this enzyme could help with regulation of blood sugar levels after a meal. In the lungs of cystic fibrosis patients, the activation of Toll-Like Receptor 5 (TLR5) in the presence of flagellin leads to inflammation and obstruction. Girolline (3-1), a known alkaloid, was isolated from a Phonpeian sponge following potent inhibition of the flagellin initiated TLR5 activation. No activity was observed in any synthetic analogues of girolline. The massacreones are a new family of ecdysteroids isolated from an unidentified Dominican cnidarian. The extract of the cnidarian had good TLR5 activity, but the massacreones – namely massacreone A (3-25) and massacreone B (3-26) have only moderate activity and a small window of activity before they are toxic. The algal pigment caulerpin (4-29) was isolated from Caulerpa sp. as a compound showing good activity in a yeast growth restoration assay designed to identify inhibitors ofhuman indoleamine-2,3-dioxygenase (IDO). Caulerpin did not show any activity in a free enzyme IDO assay. IDO is involved in immune escape, which prevents the immunological rejection of tumors.

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Drummond, Allison K. "Bioactive metabolites from microorganisms /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/drummonda/allisondrummond.pdf.

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Lavelle, S. P. "Characterisation of bioactive aerosols." Thesis, London South Bank University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618633.

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Desjardine, Kelsey Lorne. "Bioactive marine natural products." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31286.

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The chemical exploration of extracts from cultures of the marine bacterial isolate PNG-276 yielded the novel antibiotic tauramamide (2.13), a non-ribosomal peptide active against cultures of Enterococcus sp. and methicillin-resistant Staphylococcus aureus (MRSA). A study of extracts of the marine sponge Spirastrella coccinea yielded the novel macrolide methylspirastrellolide C (3.14), which is active against protein phosphatase 2A (PP2A). A third study examined sponge extracts active in a cannabinoid receptor assay, yielding two known compounds, an A- nor -steroid derivative (4.10) and bengamide A (4.11). Neither purified compound was active in the cannabinoid receptor assay, although in both cases this is the first report of these compounds being isolated from Stylissa massa and Hemiasterella aff. affinis sponges, respectively. [See Thesis for Diagrams]
Science, Faculty of
Chemistry, Department of
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Zhang, Yulan. "Diffusion of bioactive molecules." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3982/.

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An artificial liposome membrane system has been employed for in vitro screening of the human absorption of biologically active molecules for applications in nutrition and drug treatments. Initial work with molecules having small permeabilities demonstrated that they could not be measured using the technique since they were absorbed by the membrane. A critical innovation was to pre-treat the membrane by equilibrating it with the molecule of interest since this avoids the absorption problem but required more complex data analysis. Bioactive molecules with strong antioxidant and anti-cancer activity extracted from green tea showed a strong affinity to the membrane, which suggests that this significantly limits bioavailability. Ethanol but not dimethyl sulfoxide (DMSO) was found to enhance the diffusion of paracetamol, theophylline, acyclovir, nadolol and amphotericin B. The potential synergistic effect on the diffusion of paracetamol in the presence of caffeine was investigated but it was shown to have a detrimental effect. Finally, an effective protection of Epigallocatechin-3-gallate (EGCG) from the environment was achieved by the preparation of beeswax microspheres as a carrier.

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Xinping, X. "Bioactive peptides from phyllomedusinae." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677853.

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For thousands of years, Nature has' been considered to be essential for human beings for the treatment of their diseases. Amphibians are an important component of the Animal Kingdom and have played a significant role in sourcing many active compounds and some therapeutics. In the course of this research, genomic and proteomic techniques have been used to investigate the bioactive peptides from the skin secretions of four American amphibian species: the Central American red-eyed leaf frog, Agalychnis callidryas~ the South American orange-legged leaf frog, Phyllomedusa hypochondrialis, Rohde's leaf frog, Phyllomedusa rohdei and the Giant Mexican leaf frog Pachymedusa dacnicolor. The synthetic peptides all exhibited significant biological activities. Medusins were a novel family of antimicrobial peptides found in all species investigated and all possessed a broad-spectrum of antibiotic activity. Phylloseptins were found to be active against both planktonic bacteria and those within biofilms. Bradykinin-like peptides (BRPs) exhibited significant and selective activities on a range of mammalian smooth muscle preparations and one was identified as a B2 receptor antagonist using the rat tail artery. These discoveries of novel peptides from amphibian skin secretions have enriched our knowledge of bioactive peptides from this source and may provide the basis for several drug development programmes.

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She, Fengyu. "Development of Bioactive Peptidomimetics." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7571.

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Peptidomimetics are synthetic foldamers that expected more resistant to proteolytic degradation and enormous chemodiversity when compared with peptides. To date, the functional peptidomimetics such as β-peptides, peptoids, oligoureas, etc have been developed in many science fields. In order to explore the unnatural foldameric architectures, it’s necessary to discover the novel frameworks and molecular scaffolds. γ-AApeptides were reported to be a new class of peptidomimetics that showed its potential applications in drug discovery and chemical biology. However, a wide function and property of γ-AApeptides need to be further explored. To expand the potential application of γ-AApeptides in biochemistry, I have been focusing on the development of bioactive peptidomimetics, such as exploring the antibacterial activity of helical 1:1 α-sulfono-γ-AA heterogeneous peptides, developing the helical peptidomimetic as the inhibitor of the protein Ras_Raf interaction, identifying the protein/peptide ligands by the novel one-bead-two compound macrocyclic γ-AApeptide screening library, and elucidating the de novo dragon-boat-shaped synthetic foldamers.

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Martínez, Subirà Mariona. "Hull-less and coloured-grain barley as a source of valuable healthy bioactive compounds." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672377.

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Tot i que poques vegades es fa servir en els aliments, l'ordi està rebent un interès creixent com un gra saludable, per les seves propietats nutricionals. Es van estudiar a camp genotips d'ordi sense cobertes i de gra acolorit que es diferenciaven en una varietat de compostos bioactius valuosos i saludables, en diferents condicions ambientals i de temperatura. L'estrès per alta temperatura durant l'ompliment del gra va augmentar la concentració de compostos bioactius claus en el gra. S'ha de considerar la collita primerenca de grans immadurs per maximitzar la capacitat antioxidant. El 30% més extern de les fraccions perlades semblen la millor opció per explotar la capacitat antioxidant i l'alta composició fenòlica, mentre que els grans perlats poden proporcionar farines enriquides amb β-glucans. Les cobertes també són un valuós material saludable, especialment per a l'alimentació de remugants. L'ordi sense coberta i de gra morat ofereix noves vies per satisfer la creixent demanda de productes saludables, proporcionant un major contingut de fibra dietètica i compostos bioactius, una major capacitat antioxidant i un índex glucèmic estimat més baix que les farines comercials refinades i integrals de blat.
Aunque rara vez se usa en los alimentos, la cebada está recibiendo un interés creciente como un grano saludable, debido a sus propiedades nutricionales. Se estudiaron en campo genotipos de cebada sin cubiertas y de grano coloreado que se diferenciaban en una variedad de compuestos bioactivos valiosos y saludables, en diferentes condiciones ambientales y de temperatura. El estrés por alta temperatura durante el llenado del grano aumentó la concentración de compuestos bioactivos claves en el grano. Se debe considerar la cosecha temprana de granos inmaduros para maximizar la capacidad antioxidante. El 30% más externo de las fracciones perladas parecen la mejor opción para explotar la capacidad antioxidante y la alta composición fenólica, mientras que los granos perlados pueden proporcionar harinas enriquecidas con β-glucanos. Las cubiertas también son un valioso material saludable, especialmente para la alimentación de rumiantes. La cebada desnuda y de grano morado ofrece nuevas vías para satisfacer la creciente demanda de productos saludables, proporcionando un mayor contenido de fibra dietética y compuestos bioactivos, una mayor capacidad antioxidante y un índice glucémico estimado más bajo que las harinas comerciales refinadas e integrales de trigo.
Although rarely used in food, barley is receiving increasing interest as a healthy grain, due to its nutritional properties. Hull-less and coloured-grain barley genotypes differing in an array of valued and healthy bioactive compounds, were studied in the field under different temperature and environmental conditions. High temperature stress throughout grain filling increased concentration of key bioactive compounds in the grain. Early harvesting of non-mature grain should be considered as a way to maximize antioxidant capacity. The 30% outermost of the pearling fractions seem the best option to exploit antioxidant capacity and high phenolic composition, while pearled grains may provide β-glucan-enriched flours. Husks are also a valuable healthy material, particularly for ruminant feed. Hull-less and purple-grain barley offers new avenues to fulfil the increasing demand for healthy products, providing higher content of dietary fibre and bioactive compounds, greater antioxidant capacity and lower estimated glycemic index than commercial refined and whole wheat flours.

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Sandoval, Sandoval Viviana Paz. "Impact on gene expression and metabolic homeostasis of bioactive compounds-enriched diets." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671150.

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The excess of fat deposits are originated by a prolonged imbalance between the energy intake and the energy expenditure. The current food pattern based on a high consumption of saturated fats, simple sugars and processed foods, together with the sedentary lifestyle of the population, favor the development of obesity, which is responsible for 3.4 million deaths per year and is the main risk factor for the development of associated comorbidities, such as type 2 diabetes mellitus, non-alcoholic fatty liver and cardiovascular diseases. Given the current pandemic scope of obesity, finding therapeutic targets and strategies for their control and treatment is of great importance. The Mediterranean Diet, characterized by a high consumption of fruits and vegetables, provides a high levels of bioactive compounds mainly carotenoids and polyphenols, which have shown antiobesogenic properties. The main aim of this thesis is to define the molecular mechanisms involved in the metabolic impact of foods rich in bioactive compounds in animal models of obesity. We worked with sofrito and maqui to be two food products rich in bioactive compounds. Sofrito is as a typical Mediterranean preparation with a high nutritional interest due to the high content of bioactive compounds, mainly carotenoids and because beneficial effects in the primary prevention of cardiovascular and metabolic diseases such as type 2 diabetes has been attributed to it. On the other hand, the berry known as maqui (Aristotelia chilensis), characteristic of southern Chile, with a high polyphenols contents, especially from the anthocyanin group, has shown cardioprotective and hypoglycemic effects. The results show that both sofrito and maqui have beneficial effects on insulin sensitivity and glucose tolerance, respectively. As well, they are also able to increase the expression and signaling of the fibroblast growth factor pathway 21 and increase the expression of uncoupling protein 1 and browning in white adipose tissue. In addition, in the liver, the supplementation with maqui improves the hepatic steatosis caused by a high-fat diet by the expression of small heterodimer partner– interacting leucine zipper protein. The data presented allow us to point out that both dietary supplementation with sofrito and with maqui, could be good strategies in the prevention and / or treatment of obesity and its associated comorbidities.

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Books on the topic "Bioactive"

Boccaccini, Aldo R., Delia S. Brauer, and Leena Hupa, eds. Bioactive Glasses. Cambridge: Royal Society of Chemistry, 2016. http://dx.doi.org/10.1039/9781782622017.

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Onuh, John Oloche, M. Selvamuthukumaran, and Yashwant V. Pathak, eds. Bioactive Peptides. First edition. | Boca Raton : CRC Press, 2021. | Series:: CRC Press, 2021. http://dx.doi.org/10.1201/9781003052777.

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Börner, Hans G., and Jean-Francois Lutz, eds. Bioactive Surfaces. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20155-4.

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Kaur, Gurbinder. Bioactive Glasses. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45716-1.

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Thakur, Monika, and Tarun Belwal, eds. Bioactive Components. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-2366-1.

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John, Howl, and Jones Sarah Dr, eds. Bioactive peptides. Boca Raton: CRC Press/Taylor & Francis, 2009.

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Nicolaou, Anna, and George Kokotos. Bioactive lipids. Bridgwater: The Oily Press, 2004.

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Jean-François, Lutz, and SpringerLink (Online service), eds. Bioactive Surfaces. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2011.

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Eguchi, Shoji. Bioactive heterocycles. Edited by Eguchi Shoji. Berlin: Springer, 2006.

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T, Peters, and Evans S. V. 1959-, eds. Bioactive conformation. Berlin: Springer, 2007.

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Book chapters on the topic "Bioactive"

Uemura, Daisuke. "Bioactive Polyethers." In Bioorganic Marine Chemistry, 1–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76320-5_1.

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Chouzouri, Georgia, and Marino Xanthos. "Bioactive Fillers." In Functional Fillers for Plastics, 387–99. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605096.ch22.

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Rodan, Katie, Kathy Fields, and Timothy Falla. "Bioactive Peptides." In Cosmeceuticals and Cosmetic Practice, 142–52. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118384824.ch14.

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Vázquez, Luis, Marta Corzo-Martínez, Pablo Arranz-Martínez, Elvira Barroso, Guillermo Reglero, and Carlos Torres. "Bioactive Lipids." In Bioactive Molecules in Food, 467–527. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-78030-6_58.

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Chouzouri, Georgia, and Marino Xanthos. "Bioactive Fillers." In Functional Fillers for Plastics, 441–58. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527629848.ch22.

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de Oliveira, Camila Areias, and Michelli Ferrera Dario. "Bioactive Cosmetics." In Handbook of Ecomaterials, 1–23. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-48281-1_157-1.

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Kiessling, Laura L., and Laura E. Strong. "Bioactive Polymers." In Topics in Organometallic Chemistry, 199–231. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69708-x_8.

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Hupa, Leena, Xiaoju Wang, and Siamak Eqtesadi. "Bioactive Glasses." In Springer Handbook of Glass, 813–49. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-93728-1_23.

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West, Jennifer L., and Jeffrey A. Hubbell. "Bioactive Polymers." In Synthetic Biodegradable Polymer Scaffolds, 83–95. Boston, MA: Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-4154-6_5.

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LeGeros, Racquel Z., Guy Daculsi, and John P. LeGeros. "Bioactive Bioceramics." In Musculoskeletal Tissue Regeneration, 153–81. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-239-7_8.

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Conference papers on the topic "Bioactive"

Polo, Ester. "Bioactive Colloidal Nanosystems." In Advanced materials and devices for nanomedicine. València: Fundació Scito, 2022. http://dx.doi.org/10.29363/nanoge.amamed.2022.032.

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Khan, Mohidus Samad, Junfei Tian, Li Xu, Wei Shen, and Gil Garnier. "Bioactive Enzymatic Papers." In Advances in Pulp and Paper Research, Oxford 2009. Fundamental Research Committee (FRC), Manchester, 2009. http://dx.doi.org/10.15376/frc.2009.2.1149.

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The thermal stability of Alkaline phosphatase enzyme (ALP) adsorbed on paper was measured using a colorimetric technique quantifying the intensity of the product complex. ALP adsorbed on paper retains its functionality and selectivity. Adsorption of ALP on paper increased the enzyme thermal stability by 2 to 4 orders of magnitude compared to the same enzyme in solution. Complex patterns of enzyme were also printed using a thermal inkjet printer on paper. Microﬂuidic channels were printed on paper to demonstrate the concept of paper-based bioassays as diagnostic devices. Paper is an ideal material for functional materials for functional bioactive surfaces.

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Graubmann, Julia E., Sigrid Seuβ, and Aldo R. Boccaccini. "Soft Bioactive Coatings based on Electrophoretically Deposited Bioactive Glass Nanoparticles and Polycaprolactone." In Biomedical Engineering. Calgary,AB,Canada: ACTAPRESS, 2013. http://dx.doi.org/10.2316/p.2013.791-101.

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Lepienski, Carlos, and Eduardo Mioduski Szesz. "Bioactive response on Ti alloy surface induced by anodically bonded bioactive glass." In 24th ABCM International Congress of Mechanical Engineering. ABCM, 2017. http://dx.doi.org/10.26678/abcm.cobem2017.cob17-0167.

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Dufossé, Laurent. "Microbial carotenoids as bioactive food ingredients." In Foods: Bioactives, Processing, Quality and Nutrition. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/bpqn2013-01169.

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Kessler, Horst, Robert Konat, Michael Kurz, and Chaim Gilon. "Conformational design of bioactive peptides." In Future Aspect in Peptide Chemistry - Ringberg Conference. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199901086.

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Dufossé, Laurent. "Microbial aryl carotenoids as bioactive food ingredients." In Foods: Bioactives, Processing, Quality and Nutrition. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/bpqn2013-01295.

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Kwak, M., JS Kim, and TK Hyun. "Variation in bioactive compounds and bioactive principles of rosehip (Rosa rugosa Thunb.) during repening." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400146.

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Pelton, Robert. "Review: Bioactive Paper – A Paper Science Perspective." In Advances in Pulp and Paper Research, Oxford 2009, edited by S. J. I’Anson. Fundamental Research Committee (FRC), Manchester, 2009. http://dx.doi.org/10.15376/frc.2009.2.1095.

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This paper reviews the initial developments in a new field we call “bioactive paper”. At the interface between the enormous global biomedical-biotechnology research activities and the small, esoteric world of paper science research, bioactive paper research targets exciting new paper products, improving quality of life world wide. The most exciting potential implementations of bioactive paper involve leading edge concepts in genetic engineering, biochemistry, and microbiology. Current bioactive paper initiatives are summarized herein from a paper technology perspective. Elementary descriptions are given for key biological science aspects, assuming little prior knowledge, and with emphasis on the role of the paper substrate.

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Uzor, PF, and CO Nnadi. "Dereplication of Bioactive Markers from the Leaves of Anthocleista nobilis: Searching for new Bioactive Metabolites." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608074.

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Reports on the topic "Bioactive"

Taub, Floyd E. Fluorinated Analogs of Bioactive Garlic Components. Office of Scientific and Technical Information (OSTI), May 2011. http://dx.doi.org/10.2172/1018158.

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Taub, Floyd. Fluorinated Analogs of Bioactive Garlic Components. Office of Scientific and Technical Information (OSTI), May 2011. http://dx.doi.org/10.2172/1035209.

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Honn, Kenneth. Bioactive Lipids: Role in Prostate Cancer Angiogenesis. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada405532.

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Honn, Kenneth V. Bioactive Lipids: Role in Prostate Cancer Angiogenesis. Fort Belvoir, VA: Defense Technical Information Center, April 2003. http://dx.doi.org/10.21236/ada419706.

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Honn, Kenneth. Bioactive Lipids: Role in Prostate Cancer Angiogensis. Fort Belvoir, VA: Defense Technical Information Center, October 1999. http://dx.doi.org/10.21236/ada384373.

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Teixeira, Carla, Caterina Villa, Joana Costa, Isabel M. P. L. V. O. Ferreira, and Isabel Mafra. Edible insects as a source of bioactive peptides. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2023. http://dx.doi.org/10.37766/inplasy2023.3.0075.

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Review question / Objective: This systematic review aimed at performing an exhaustive bibliographic search of all research articles reporting sequenced bioactive peptides obtained from edible insects and the respective properties demonstrated by in silico, in vitro and/or in vivo approaches. This report intends to evaluate the existing weigh-of-evidence regarding each specific claimed bioactive property, thus representing a valuable contribution to the divulgation of the scientific basis on the health benefits associated to the consumption of insects. Condition being studied: Insects are a good source of bioactive peptides (3-20 amino acids residues in length that promote beneficial effects for human health), including antihypertensive, antidiabetic, antioxidant, anti-obesity, immunomodulatory, anti-inflammatory, anti-microbial, antiviral, and antithrombotic properties, among others.

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López-Valverde, Nansi, Javier Aragoneses, Antonio López-Valverde, Cinthia Rodríguez, and Juan Manuel Aragoneses. Role in the osseointegration of titanium dental implants, of bioactive surfaces based on biomolecules: A systematic review and meta-analysis of in vivo studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0076.

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Review question / Objective: Does the bioactive surface of titanium dental implants, based on biomolecules, influence osseointegration?. The aim of our study was to evaluate the role and efficacy of bioactive surfaces in osseointegration. Our review study limited the research interest to titanium dental implants coated with a biomolecule, i.e., an organic molecule produced by a living organism. Condition being studied: In recent years, much attention has been paid to topographical modifications of dental implant surfaces, as well as to their coating with biologically active substances.a bioactive surface is one capable of achieving faster and higher quality osseointegration, shortening waiting times and solving situations of poor bone quality. Molecules that can be applied for bioactive purposes include bioceramics, ions and biomolecules. Collagen and bone morphogenetic protein have been suggested as bone stimulating agents. Biofunctionalization of the implant surface with a biomimetic active peptide has also been shown to result in a significant increase in bone-to-implant ratios and an increase in peri-implant bone density.

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Honn, Kenneth. Phase I Bioactive Lipids: Role in Prostate Cancer Angiogenesis"". Fort Belvoir, VA: Defense Technical Information Center, October 2000. http://dx.doi.org/10.21236/ada394907.

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Yamil Liscano, Yamil Liscano. New bioactive peptides from skin of a colombian frog. Experiment, March 2018. http://dx.doi.org/10.18258/10880.

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Campbell, A. A. Bioactive and Porous Metal Coatings for Improved Tissue Regeneration. Office of Scientific and Technical Information (OSTI), January 2000. http://dx.doi.org/10.2172/770345.

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