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Journal articles on the topic 'Bioactifs'

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Published: 7 July 2024

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1

Bigliardi, Paul, Nicolas Grasset, and Wassim Raffoul. "[b]Pansements[/b] bioactifs." Revue Médicale Suisse 6, no. 236 (2010): 354–57. http://dx.doi.org/10.53738/revmed.2010.6.236.0354.

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2

Ktari., Naourez, Najiba Zeghal., and Moncef Nasri. "Hypoglycemic effects of bioactive peptides from dietary origin." Nutrition & Santé 03, no. 01 (June 30, 2014): 10–22. http://dx.doi.org/10.30952/ns.3.1.3.

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3

Durrieu, M. C. "Conception, élaboration et caractérisation de matériaux bioactifs." ITBM-RBM 26, no. 3 (June 2005): 229–37. http://dx.doi.org/10.1016/j.rbmret.2005.04.004.

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4

Benlebna, Melha, Laurence Balas, François Casas, Sylvie Gaillet, Charles Coudray, Thierry Durand, and Christine Feillet-Coudray. "Les FAHFAs, une nouvelle classe de lipides endogènes bioactifs." Cahiers de Nutrition et de Diététique 53, no. 2 (April 2018): 100–105. http://dx.doi.org/10.1016/j.cnd.2018.01.004.

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5

Montaut, S., P. Rollin, G. R. De Nicola, R. Iori, and A. Tatibouët. "Composés bioactifs des Crucifères : un apport bénéfique dans notre quotidien." Phytothérapie 10, no. 6 (December 2012): 342–49. http://dx.doi.org/10.1007/s10298-012-0740-z.

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6

Alvarado, Katherine, Erwann Durand, Laurent Vaysse, Siriluck Liengprayoon, Sylvie Gaillet, Charles Coudray, François Casas, and Christine Feillet-Coudray. "Effets bénéfiques potentiels des acides gras furaniques, des lipides alimentaires bioactifs." Cahiers de Nutrition et de Diététique 56, no. 2 (April 2021): 117–25. http://dx.doi.org/10.1016/j.cnd.2021.01.006.

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7

Mouloungui, Zéphirin, Jane Roche, and Andrée Bouniols. "Limitations extractives des ingrédients fonctionnels natifs : lipides bioactifs par modifications chimiques." Oléagineux, Corps gras, Lipides 13, no. 1 (January 2006): 16–22. http://dx.doi.org/10.1051/ocl.2006.0016.

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8

Dembele, Daouda Lassine, Aimé Ainin Somboro, Sékou Doumbia, Mamadou Lamine Diarra, Mahamane Haïdara, and Sanogo Rokia. "Etude pharmacognosique des feuilles, écorces de racines, écorces de tronc et de la racine entière de <i>Securidaca longipeduncultata</i> Fresen (Polygalaceae), récoltées au Mali." International Journal of Biological and Chemical Sciences 17, no. 4 (September 19, 2023): 1701–16. http://dx.doi.org/10.4314/ijbcs.v17i4.32.

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Au Mali, les racines de Securidaca longipedunculata sont fortement utilisées et les peuplements de l’espèce se font de plus en plus rares. Ce travail visait à effectuer une étude comparative des paramètres pharmacognosiques des feuilles, écorces de tronc, écorces de racine et de la racine entière. Les échantillons ont été analysés pour déterminer les caractéristiques botaniques et physicochimiques. Des extraits aqueux et organiques ont été préparés pour caractériser les principaux constituants bioactifs par des techniques colorimétriques et chromatographiques. Les composés majoritaires ont été extraits par ultrasons et quantifiés. Les éléments botaniques communs étaient des fibres, cristaux d’oxalate de calcium, xylèmes et parenchymes. Des sclérites et fragments d’épiderme étaient seulement dans les feuilles. Le meilleur rendement d’extraction a été obtenu avec l’éthanol. Les principaux constituants étaient des tanins, flavonoïdes, coumarines, anthraquinones et saponines dans les feuilles ; des coumarines et saponines dans les écorces de tronc, écorces de racine et la racine entière. Les constituants majoritaires étaient des saponines triterpéniques dont 1,51 g de précipités enrichis ont été extraits à partir des écorces de racine. Les feuilles ont qualitativement présenté le plus de constituants bioactifs. Des investigations sont nécessaires pour évaluer leur efficacité afin de diminuer la pression sur les racines. English title: Pharmacognostic study of the leaves, root bark, trunk bark and whole root of Securidaca longipeduncultata Fresen (Polygalaceae), harvested in Mali In Mali, the roots of Securidaca longipedunculata are used extensively, and stands of the species are becoming increasingly are becoming increasingly rare. The aim of this work was to carry out a comparative study of the pharmacognosic parameters of leaves, trunk bark, root bark and the whole root. Samples were analyzed for botanical and physicochemical characteristics. Aqueous and organic extracts were prepared to characterize the main bioactive constituents using colorimetric and chromatographic techniques. Major compounds were ultrasonically extracted and quantified. Common botanical elements were fibers, calcium oxalate crystals, xylem and parenchyma. Sclerites and epidermal fragments were only found in leaves. The best extraction yield was obtained with ethanol. The main constituents were tannins, flavonoids, coumarins, anthraquinones and saponins in the leaves; coumarins and saponins in the trunk bark, root bark and whole root. The main constituents were triterpene saponins, of which 1.51 g of enriched precipitates were extracted from root barks. Leaves qualitatively presented the most bioactive constituents. Further investigations are needed to assess their effectiveness in reducing pressure on the roots.
9

Cani, Patrice D. "Microbiote intestinal et obésité : impact des lipides bioactifs issus du système endocannabinoïde." OCL 23, no. 3 (March 25, 2016): D305. http://dx.doi.org/10.1051/ocl/2016011.

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10

Levrier, O., M. Benathan, and N. Girard. "P-35 - Traitement des brèches artérioveineuses crâniocervicales à l’aide de stents couverts bioactifs." Journal of Neuroradiology 33, no. 1 (February 2006): 23–24. http://dx.doi.org/10.1016/s0150-9861(06)77218-2.

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11

Benlebna, M., L. Balas, B. Bonafos, L. Pessemesse, G. Fouret, S. Gaillet, T. Durand, C. Coudray, F. Casas, and C. Feillet-Coudray. "Impact de lipides bioactifs, les FAHFAs, sur les désordres métaboliques associés à l’obésité." Nutrition Clinique et Métabolisme 33, no. 1 (March 2019): 35. http://dx.doi.org/10.1016/j.nupar.2019.01.280.

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12

Spelle, L., C. Mounayer, M. Piotin, D. Abud, R. Vanzin, and J. Moret. "CO-10 Utilisation de coïls bioactifs dans le traitement endovasculaire des anévrismes intracrâniens." Journal of Neuroradiology 31, no. 2 (March 2004): 88. http://dx.doi.org/10.1016/s0150-9861(04)96897-6.

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13

Levrier, O., M. Bennathan, and G. Nadine. "RI22 Interet des stents couverts bioactifs dans le traitement des breches arerioveineuses craniocephaliques." Journal de Radiologie 87, no. 10 (October 2006): 1536. http://dx.doi.org/10.1016/s0221-0363(06)87895-9.

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14

Mayingi, J., G. Hélary, F. Noirclere, B. Bacroix, and V. Migonney. "Synthèse et greffage de polymères bioactifs sur des surfaces en titane pour favoriser l’ostéointégration." IRBM 29, no. 1 (March 2008): 1–6. http://dx.doi.org/10.1016/j.rbmret.2007.10.001.

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15

Simionescu, C. R., Y. Bouzaher, and S. Dumitriu. "Polymères Bioactifs X. Insolubilisation de la β-Amylase sur des Dérivés de la Cellulose." Bulletin des Sociétés Chimiques Belges 90, no. 9 (September 1, 2010): 939–46. http://dx.doi.org/10.1002/bscb.19810900909.

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16

Diet, A., G. Cardin, M. Bonnet, P. Veisseire, J. Priam, E. Saunier, C. Decombat, F. Caldefie-Chezet, and L. Rios. "Les fromages comme nouvelle source de métabolites bioactifs innovants capables d’impacter le stress oxydant." Nutrition Clinique et Métabolisme 37, no. 2 (May 2023): e68-e69. http://dx.doi.org/10.1016/j.nupar.2023.03.124.

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17

Gieré, C., S. Dutertre, and P. Poisbeau. "Les cônes marins, une ressource naturelle d’antalgiques venue du fond des mers : au-delà du ziconotide ?" Douleur et Analgésie 32, no. 4 (December 2019): 196–204. http://dx.doi.org/10.3166/dea-2020-0077.

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Les cônes marins sont des animaux remarquables qui ont développé au cours de l’évolution des outils leur permettant de survivre et de se nourrir sous la mer quels que soient le prédateur ou la proie auxquels ils pourraient être confrontés. Leurs venins de prédation et de défense contiennent des centaines de peptides bioactifs dont l’ω- conotoxine ziconotide, première conotoxine thérapeutique utilisée dans le traitement des douleurs chroniques intenses et pharmacorésistantes aux traitements antalgiques recommandés comme la morphine. Cette revue fait le point sur le mode d’action du ziconotide et met en valeur d’autres composés de venins de cônes ayant un potentiel thérapeutique pour traiter les douleurs pathologiques.
18

Eboma, Rachael Nkechi, Clement Olusola Ogidi, and Bamidele Juliet Akinyele. "Bioactive compounds and antimicrobial activity of extracts from fermented African locust bean (Parkia biglobosa ) against pathogenic microorganisms." North African Journal of Food and Nutrition Research 4, no. 08 (January 1, 2021): 343–50. http://dx.doi.org/10.51745/najfnr.4.08.343-350.

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Background: The challenges of multiple antibiotic resistance by pathogenic microorganisms has necessitated the need for a continuous search for new and effective antimicrobial bioactive compounds. Objectives: In this study, the antimicrobial activity of extracts from fermented condiment from Parkia biglobosa was investigated against some pathogenic microorganisms. Materials and Methods: Gas chromatography - mass spectrometry (GC-MS) was used to identify bioactive compounds in n-hexane extract (oil). Aqueous and n-hexane extracts of locust beans were tested against clinical isolates; viz., Klebsiella spp., Aeromonas hydrophilia, Citrobacter braakii, Enterobacter aerogenes, Shigella dysenteriae, Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli, Methicillin-Resistant Staphylococcus aureus (MRSA), Aspergillus spp. and Candida albicans using agar well diffusion method. Results: The study revealed the phytochemicals in oil as phenols (41.8 mg/100g), flavonoids of 19.37 mg/100g, saponins (16.7 mg/100g), alkaloids (22.9 mg/100g), steroids (6.9 mg/100g), terpenoids (10.0 mg/100g) and cardiac glycosides (3.3 mg/100g). The aqueous extract contains phenols (33.7 mg/100g), flavonoids (12.3 mg/100g), alkaloids (17.6 mg/100g), saponins (5.0 mg/100g) and cardiac glycosides (1.2 mg/100g). The bioactive compounds in the n-hexane extract were ricinoleic acid, p-cymene, octadecanoic acid, n-hexadecanoic acid and others. Oil from fermented locust bean exhibited zones of inhibition ranging from 5 mm to 14 mm against the tested isolates at 10 mg/mL, while the aqueous extract displayed inhibition zones of 4 mm to 10 mm at 10.0 mg/mL. Conclusion: The chemical constituents in locally fermented condiment (locust bean) are responsible for pronounced antimicrobial properties. Hence, the condiment can be exploited for medicinal purposes. Keywords: Fermented food, condiment, n-hexane, phytochemicals and antimicrobials.
19

Ben Aissa, I., G. Helary, and V. Migonney. "Le greffage radicalaire de polymères bioactifs sur le titane pour prévenir l’infection sur prothèse articulaire." IRBM 32, no. 5 (November 2011): 322–25. http://dx.doi.org/10.1016/j.irbm.2011.07.002.

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20

Bouzaher, Y., S. Dumitriu, and Cr Simionescu. "Les Polymères Bioactifs XI. Insolubilisation de la β-Amylase Sur les Dérivés de la Cellulose." Bulletin des Sociétés Chimiques Belges 91, no. 3 (September 1, 2010): 189–97. http://dx.doi.org/10.1002/bscb.19820910303.

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21

Bouyahya, A., J. Abrini, Y. Bakri, and N. Dakka. "Les huiles essentielles comme agents anticancéreux : actualité sur le mode d’action." Phytothérapie 16, no. 5 (October 2018): 254–67. http://dx.doi.org/10.3166/s10298-016-1058-z.

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Le cancer est une maladie complexe qui présente un réel problème de santé publique à travers le monde et cause statiquement sept millions de décès chaque année. Au cours des dernières décennies, la thérapie anticancéreuse a connu un réel bouleversement et un foisonnement de découvertes fondamentales. Plusieurs études accumulatives ont révélé l’activité antitumorale des substances naturelles isolées à partir de plantes. Les huiles essentielles (HE) et leurs constituants ont montré des activités anticancéreuses puissantes in vitro et in vivo. Cependant, les mécanismes d’action sont encore peu étudiés et moins connus. Par ailleurs, leur application dans l’industrie pharmaceutique nécessite une spécificité– sélectivité pharmacodynamique absolue. Dans le présent travail, nous présentons une synthèse des travaux réalisés sur les mécanismes d’actions anticancéreuses des HE et leurs composés bioactifs.
22

Schaaf, P., and J. C. Voegel. "Films bioactifs destinés au recouvrement de biomatériaux et ciblant une régénération tissulaire : de nouvelles voies originales ?" Pathologie Biologie 50, no. 3 (April 2002): 189–93. http://dx.doi.org/10.1016/s0369-8114(02)00287-0.

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23

LÉONIL, J., M. C. MICHALSKI, and P. MARTIN. "Les structures supramoléculaires du lait : structure et impact nutritionnel de la micelle de caséine et du globule gras." INRAE Productions Animales 26, no. 2 (April 17, 2013): 129–44. http://dx.doi.org/10.20870/productions-animales.2013.26.2.3142.

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La présence d’une diversité de molécules spécifiques qui coexistent dans le lait sous forme de structures supramoléculaires, telles les micelles de caséine et les globules gras, fait de ce fluide biologique un système extraordinairement complexe, physiquement stable, capable de vectoriser les composés bioactifs présents aussi bien dans sa fraction protéique que dans sa fraction lipidique. Les avancées réalisées tant sur la composition que sur l’organisation structurale de ces structures, même s’il subsiste des zones d’ombre, nous montrent que cette organisation n’est pas sans importance sur les effets qu’elles exercent sur l’organisme. La mise en évidence dans le lait de nanovésicules sécrétées par la cellule épithéliale mammaire (lactosomes) et capables de transmettre à d’autres cellules ou organismes des informations d’une autre nature constitue, à cet égard, un nouveau champ d’investigation passionnant.
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Dubernat, Laure, Lucie Marousez, Jean-Luc Desseyn, Valérie Gouyer, Emmanuel Hermann, Frédéric Gottrand, Delphine Ley, and Jean Lesage. "Les oligosaccharides du lait maternel : des rôles majeurs pour le développement de l’enfant et sa santé future." médecine/sciences 39, no. 11 (November 2023): 869–75. http://dx.doi.org/10.1051/medsci/2023164.

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En raison de sa capacité à fournir des apports nutritionnels optimaux ainsi que de nombreux facteurs bioactifs, tels que des oligosaccharides, le lait maternel est considéré comme le régime alimentaire optimal pour les nouveau-nés. Les oligosaccharides du lait humain (HMO) constituent le troisième composant du lait maternel. Plus de 150 HMO ont été caractérisés, leur concentration variant de 5 à 20 g/L. Certaines préparations infantiles enrichies en HMO sont désormais disponibles, même si leurs effets sur la santé restent à démontrer. La poursuite des recherches pourrait permettre d’envisager leur utilisation chez les enfants prématurés ou présentant des maladies inflammatoires digestives. Des données expérimentales suggèrent en effet que les HMO pourraient prévenir certaines maladies chroniques à composantes immuno-métaboliques ou neurodéveloppementales. Dans cette revue, nous présentons une synthèse des dernières données montrant les effets biologiques de ces oligosaccharides.
25

ZAMORA, J., H. Brunel, G. Bourbotte, and A. Bonafe. "CO-53 - Nouvelles posibilités de traitement endovasculaire des anévrysmes à collet large : association endoprothèse et microcoïls bioactifs." Journal of Neuroradiology 33, no. 1 (February 2006): 15. http://dx.doi.org/10.1016/s0150-9861(06)77173-5.

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26

Léonil, J. "Les peptides bioactifs du lait et leur intérêt dans la prévention des maladies cardiovasculaires et du syndrome métabolique." Médecine des Maladies Métaboliques 8, no. 5 (October 2014): 495–99. http://dx.doi.org/10.1016/s1957-2557(14)70863-6.

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27

Kouadio, Adjoua L., Gaoueh Gnahoue, Mireille K. T. Kple, Georges Abizi, Serge D. Kone, and Mathieu K. A. Kra. "Effet des extraits des feuilles de Ficus sycomorus sur les paramètres hématologiques et biochimiques des rats Wistar." International Journal of Biological and Chemical Sciences 16, no. 2 (July 8, 2022): 680–94. http://dx.doi.org/10.4314/ijbcs.v16i2.14.

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Ficus sycomorus est une plante présente dans le nord de la Côte d’Ivoire et dont les feuilles sont prisées par les éleveurs pour leurs bétails. Cependant, des données scientifiques sur la toxicité et la composition phytochimique de cette plante sont méconnues en Côte d’Ivoire. L’objectif de ce travail était d’évaluer la toxicité aiguë et subaiguë des extraits issus des feuilles de Ficus sycomorus chez des rats Wistar. Les extraits aqueux et hydroéthanolique ont été obtenus par macération (homogénéisation). Les résultats obtenus ont révélé que ces extraits contiennent des composés bioactifs qui donneraient aux feuilles des propriétés pharmacologiques. Les feuilles de Ficus sycomorus sont sans danger pour la santé car la DL50 des extraits est supérieure à 5000 mg/kg. De plus, l’utilisation quotidienne des extraits a révélé leurs activités néphro, hépato et cardio protectrice. Une diminution du poids relatif du foie des rats femelles traités a été observée ainsi qu’une augmentation significative du taux de globules blancs et des plaquettes sanguines de tous les animaux traités. Ces extraits ont également significativement baissé le taux de LDL-cholestérol des animaux traités. Ces résultats montrent que ces extraits de feuilles n’ont généré aucun dommage durant la période d’étude, aux doses étudiées.
28

F. C., Egenuka, Okeudo N. J, Obikaonu H. O., Ogbuewu I. P., and Aladi N. O. "Changes in the bioactive compounds of sun-dried ginger rhizome and their effects on growth performance, blood profile, carcass and meat quality of broiler chickens." Nigerian Journal of Animal Production 50, no. 2 (February 28, 2024): 120–40. http://dx.doi.org/10.51791/njap.v50i2.3971.

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Phytogenic feed additives such as ginger, garlic and turmeric are plant derived products which when added to livestock feed have the ability to enhance livestock performance through the improvement of digestibility, absorption of nutrients, and are also able to eliminate pathogenic microbes residing in the gut of the animal. The effects of sun drying on the bioactive components of ginger and subsequent performance of broiler chickens were evaluated using 180 broiler chicks of Arbor Acres strain. Fresh ginger rhizomes were cut into 2-3 mm thick slices., sundried and then milled. The proximate and bioactive compositions of fresh and sundried samples were determined. Thereafter, three experimental broiler diets were formulated such that diets 1 (control) and 3 contained no ginger. Diet 2 contained 0.5 % sundried ginger meal. However, broilers placed on diet 3 were also offered a fresh equivalent of 0.5 % sundried ginger through the drinking water. Data was collected on growth performance parameters, haematology and serum biochemical indices, carcass and meat quality characteristics. Twenty and nineteen bioactive compounds were identified in the fresh ginger and sundried ginger rhizomes respectively, with most of the components being higher in concentration in fresh than in dry ginger. Gingerol and shogaol were present in fresh but not in dry ginger while alpha-cedrol detected in dry ginger was not found in fresh ginger. Final live-weight, weight gain, feed intake and feed conversion ratio were not significantly (p>0.05) affected by dietary treatments in the starter phase. In the finisher phase, live-weight, weight gain and growth rate were significantly (p < 0.05) higher in the fresh ginger group compared to dry ginger and control groups. The cost of feed consumed was significantly (p < 0.05) higher in the ginger groups compared to the control group while feed cost per kilogram weight gain was significantly higher in dry ginger compared to fresh ginger and control groups. Carcass and meat quality parameters were not significantly (p>0.05) affected by fresh or dry ginger treatment. The haematological indices were not significantly (p>0.05) affected by either form of ginger supplementation. Serum glucose concentration was significantly (p<0.05) reduced by the inclusion of dry ginger in broiler chicken diets (T2). The study, therefore, concluded that providing broiler chickens with fresh ginger through drinking water was more efficacious in promoting growth performance than the inclusion of sundried ginger in the diets. Les additifs alimentaires phytogéniques tels que le gingembre, l'ail et le curcuma sont des produits dérivés de plantes qui, lorsqu'ils sont ajoutés à l'alimentation du bétail, ont la capacité d'améliorer les performances du bétail en améliorant la digestibilité et l'absorption des nutriments, et sont également capables d'éliminer les microbes pathogènes résidant dans l'intestin des animaux. l'animal. Les effets du séchage au soleil sur les composants bioactifs du gingembre et les performances ultérieures des poulets de chair ont été évalués en utilisant 180 poussins de chair de la souche Arbor Acres. Les rhizomes de gingembre frais ont été coupés en tranches de 2 à 3 mm d'épaisseur, séchés au soleil puis moulus. Les compositions immédiates et bioactives d'échantillons frais et séchés ont été déterminées. Par la suite, trois régimes expérimentaux pour poulets de chair ont été formulés de telle sorte que les régimes 1 (témoin) et 3 ne contenaient pas de gingembre. Le régime 2 contenait 0,5 % de farine de gingembre séché au soleil. Cependant, les poulets de chair soumis au régime 3 se sont également vu proposer un équivalent frais de 0,5 % de gingembre séché au soleil dans l'eau de boisson. Des données ont été collectées sur les paramètres de performance de croissance, les indices hématologiques et biochimiques sériques, les caractéristiques de qualité des carcasses et de la viande. Vingt et dix-neuf composés bioactifs ont été identifiés respectivement dans les rhizomes du gingembre frais et du gingembre séché, la plupart des composants ayant une concentration plus élevée dans le gingembre frais que dans le gingembre sec. Le gingérol et le shogaol étaient présents dans le gingembre frais mais pas dans le gingembre sec, tandis que l'alpha-cédrol détecté dans le gingembre sec n'était pas trouvé dans le gingembre frais. Le poids vif final, le gain de poids, la consommation alimentaire et le taux de conversion alimentaire n'ont pas été affectés de manière significative (p > 0,05) par les traitements diététiques pendant la phase de démarrage. Dans la phase de finition, le poids vif, le gain de poids et le taux de croissance étaient significativement (p < 0,05) plus élevés dans le groupe de gingembre frais par rapport au groupe de gingembre sec et aux groupes témoins. Le coût de l'alimentation consommée était significativement (p < 0,05) plus élevé dans les groupes de gingembre par rapport au groupe témoin, tandis que le coût de l'alimentation par kilogramme de gain de poids était significativement plus élevé dans le groupe de gingembre sec que dans le groupe de gingembre frais et de contrôle. Les paramètres de qualité de la carcasse et de la viande n'étaient pas affectés de manière significative (p>0,05) par le traitement au gingembre frais ou sec. Les indices hématologiques n'étaient pas affectés de manière significative (p>0,05) par l'une ou l'autre forme de supplémentation en gingembre. La concentration sérique de glucose était significativement (p <0,05) réduite par l'inclusion de gingembre sec dans l'alimentation des poulets de chair (T2). L'étude a donc conclu que fournir aux poulets de chair du gingembre frais dans l'eau potable était plus efficace pour favoriser les performances de croissance que l'inclusion de gingembre séché au soleil dans l'alimentation.
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Egenuka, F. C., N. J. Okeudo, H. O. Obikaonu, I. P. Ogbuewu, and N. O. Aladi. "Changes in the bioactive compounds of sun-dried ginger rhizome and their effects on growth performance, blood profile, carcass and meat quality of broiler chickens." Nigerian Journal of Animal Production 50, no. 1 (December 6, 2023): 123–39. http://dx.doi.org/10.51791/njap.v50i1.3910.

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Phytogenic feed additives such as ginger, garlic and turmeric are plant derived products which when added to livestock feed have the ability to enhance livestock performance through the improvement of digestibility, absorption of nutrients, and are also able to eliminate pathogenic microbes residing in the gut of the animal. The effects of sun drying on the bioactive components of ginger and subsequent performance of broiler chickens were evaluated using 180 broiler chicks of Arbor Acres strain. Fresh ginger rhizomes were cut into 2-3 mm thick slices., sundried and then milled. The proximate and bioactive compositions of fresh and sundried samples were determined. Thereafter, three experimental broiler diets were formulated such that diets 1 (control) and 3 contained no ginger. Diet 2 contained 0.5 % sundried ginger meal. However, broilers placed on diet 3 were also offered a fresh equivalent of 0.5 % sundried ginger through the drinking water. Data was collected on growth performance parameters, haematology and serum biochemical indices, carcass and meat quality characteristics. Twenty and nineteen bioactive compounds were identified in the fresh ginger and sundried ginger rhizomes respectively, with most of the components being higher in concentration in fresh than in dry ginger. Gingerol and shogaol were present in fresh but not in dry ginger while alpha-cedrol detected in dry ginger was not found in fresh ginger. Final live-weight, weight gain, feed intake and feed conversion ratio were not significantly (p>0.05) affected by dietary treatments in the starter phase. In the finisher phase, live-weight, weight gain and growth rate were significantly (p < 0.05) higher in the fresh ginger group compared to dry ginger and control groups. The cost of feed consumed was significantly (p < 0.05) higher in the ginger groups compared to the control group while feed cost per kilogram weight gain was significantly higher in dry ginger compared to fresh ginger and control groups. Carcass and meat quality parameters were not significantly (p>0.05) affected by fresh or dry ginger treatment. The haematological indices were not significantly (p>0.05) affected by either form of ginger supplementation. Serum glucose concentration was significantly (p<0.05) reduced by the inclusion of dry ginger in broiler chicken diets (T2). The study, therefore, concluded that providing broiler chickens with fresh ginger through drinking water was more efficacious in promoting growth performance than the inclusion of sundried ginger in the diets. Les additifs alimentaires phytogéniques tels que le gingembre, l’ail et le curcuma sont des produits dérivés de plantes qui, lorsqu’ils sont ajoutés à l’alimentation du bétail, ont la capacité d’améliorer les performances du bétail en améliorant la digestibilité et l'absorption des nutriments, et sont également capables d'éliminer les microbes pathogènes résidant dans l'intestin des animaux. L’animal. Les effets du séchage au soleil sur les composants bioactifs du gingembre et les performances ultérieures des poulets de chair ont été évalués en utilisant 180 poussins de chair de la souche Arbor Acres. Les rhizomes de gingembre frais ont été coupés en tranches de 2 à 3 mm d'épaisseur, séchés au soleil puis moulus. Les compositions immédiates et bioactives d’échantillons frais et séchés ont été déterminées. Par la suite, trois régimes expérimentaux pour poulets de chair ont été formulés de telle sorte que les régimes 1 (témoin) et 3 ne contenaient pas de gingembre. Le régime 2 contenait 0,5 % de farine de gingembre séché au soleil. Cependant, les poulets de chair soumis au régime 3 se sont également vu proposer un équivalent frais de 0,5 % de gingembre séché au soleil dans l’eau de boisson. Des données ont été collectées sur les paramètres de performance de croissance, les indices hématologiques et biochimiques sériques, les caractéristiques de qualité des carcasses et de la viande. Vingt et dix-neuf composés bioactifs ont été identifiés respectivement dans les rhizomes du gingembre frais et du gingembre séché, la plupart des composants ayant une concentration plus élevée dans le gingembre frais que dans le gingembre sec. Le gingérol et le shogaol étaient présents dans le gingembre frais mais pas dans le gingembre sec, tandis que l’alpha-cédrol détecté dans le gingembre sec n’était pas trouvé dans le gingembre frais. Le poids vif final, le gain de poids, la consommation alimentaire et le taux de conversion alimentaire n'ont pas été affectés de manière significative (p > 0,05) par les traitements diététiques pendant la phase de démarrage. Dans la phase de finition, le poids vif, le gain de poids et le taux de croissance étaient significativement (p < 0,05) plus élevés dans le groupe de gingembre frais par rapport au groupe de gingembre sec et aux groupes témoins. Le coût de l’alimentation consommée était significativement (p < 0,05) plus élevé dans les groupes de gingembre par rapport au groupe témoin, tandis que le coût de l'alimentation par kilogramme de gain de poids était significativement plus élevé dans le groupe de gingembre sec que dans le groupe de gingembre frais et de contrôle. Les paramètres de qualité de la carcasse et de la viande n’étaient pas affectés de manière significative (p>0,05) par le traitement au gingembre frais ou sec. Les indices hématologiques n’étaient pas affectés de manière significative (p>0,05) par l’une ou l’autre forme de supplémentation en gingembre. La concentration sérique de glucose était significativement (p <0,05) réduite par l’inclusion de gingembre sec dans l’alimentation des poulets de chair (T2). L’étude a donc conclu que fournir aux poulets de chair du gingembre frais dans l’eau potable était plus efficace pour favoriser les performances de croissance que l’inclusion de gingembre séché au soleil dans l’alimentation.
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Poussard, L., C. P. Ouédraogo, G. Pavon-Djavid, and V. Migonney. "Inhibition de l’adhérence de Staphylococcus epidermidis sur des surfaces en titane par des polymères hydrosolubles bioactifs comportant des fonctions sulfonate, phosphate ou carboxylate." Pathologie Biologie 60, no. 2 (April 2012): 84–90. http://dx.doi.org/10.1016/j.patbio.2010.07.004.

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REHAULT, S., M. ANTON, F. NAU, J. GAUTRON, and Y. NYS. "Les activités biologiques de l’œuf." INRAE Productions Animales 20, no. 4 (November 7, 2007): 337–48. http://dx.doi.org/10.20870/productions-animales.2007.20.4.3470.

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L’œuf se compose d’une grande diversité de nutriments et de molécules actives «programmés» pour permettre le développement autonome d’un embryon dans un milieu confiné. Ces molécules d’intérêt sont réparties de manière équilibrée entre les différents compartiments de l’œuf (coquille, blanc, jaune, membranes) qui assurent chacun une fonction bien déterminée. Outre les éléments nutritifs essentiels à l’embryogenèse, on y trouve de multiples molécules participant au développement et à la protection de l’embryon qu’elle soit physique (coquille, membranes) ou chimique (molécules antibactériennes, antivirales, antioxydantes). Pour l’homme, l’œuf constitue un aliment de haute valeur nutritionnelle mais de plus en plus, il apparaît comme riche de nombreuses molécules actives d’intérêt majeur pour différents secteurs industriels tels que l’agroalimentaire, les biotechnologies, la cosmétique ou la santé humaine et animale. Les propriétés antibactériennes des protéines du blanc d’œuf sont connues depuis longtemps, mais il émerge depuis plusieurs années des activités particulièrement prometteuses en médecine humaine telles que des propriétés anti-adhésives, immuno-modulatrices, anti-hypertensives, anti-cancéreuses, anti-inflammatoires ou cryoprotectrices. Certaines de ces activités ne sont pas portées par les protéines natives mais par des peptides dérivés, générés in vitro par protéolyse ménagée des protéines de l’œuf. Ces peptides et protéines bioactifs présentent un intérêt grandissant depuis quelques années et de nombreux efforts sont actuellement menés pour tenter de mieux caractériser leurs applications potentielles.
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Oddoux, S., P. Violette, J. Cornet, J. Akkoyun-Farinez, M. Besnier, A. Noël, and F. Rouillon. "Effet d’un complément alimentaire associant des peptides bioactifs et du magnésium sur le trouble de l’adaptation avec anxiété : un essai clinique en médecine générale." Nutrition Clinique et Métabolisme 37, no. 2 (May 2023): e101. http://dx.doi.org/10.1016/j.nupar.2023.03.187.

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ZIAR, Hasnia, Imène YAHLA, and Ali RIAZI. "Conjugated isomers of linoleic acid and health: What about those of bacterial origin ?" Nutrition & Santé 11, no. 01 (June 16, 2022): 1–11. http://dx.doi.org/10.30952/ns.11.1.1.

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In addition to their effect on body composition (fat reduction), conjugated linoleic acid isomers (CLA) can play several health benefits, including anti-cancer, anti-atherogenic, anti-adipogenic, anti-diabetic, anti-inflammatory, possible cholesterolemia regulation, and immune function stimulation. Probiotics have been found to produce CLA, however, there is still controversy in the results obtained on the production and effects of human gut bacterial CLA reported in literature. Most of the biological effects have been attributed to cis9, trans11, and trans10, cis12 isomers. The aim of this review was to highlight and discuss how probiotic bacterial CLA isomers provided health benefits. [Au-delà des effets des isomères conjugués de l’acide linoléique (conjugated linoleic acid isomers (CLA)) sur la composition corporelle (diminution de la graisse), ces composés bioactifs ont des effets sur la santé humaine, tels que les effets anti-can-céreux, anti-athérogéniques, anti-adipogéniques, anti-diabétiques, antiinflammatoires, impact potentiel sur la cholestérolémie et stimulation de la fonction immunitaire. Les bactéries probiotiques ont été trouvées capables de conjuguer l’acide linoléique. Toutefois, peu d’études ont mis le point sur cette production des isomères conjugués d’acide linoléique par des bactéries intestinales humaines et restent peu concluantes. Leurs effets santé ont été reliés à deux types d’isomères, à savoir le 9cis, 11trans et le 10trans, 12cis. La présente mise au point a pour objet de souligner les données disponibles concernant les effets des isomères CLA sur la santé, en particulier ceux produits par des bactéries probiotiques. Les mécanismes impliqués dans leurs activités sont aussi évoqués.]
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Ouma, Stephen, Richard Kagia, and Faith Kamakia. "Determination of pharmacological activity of bioactives in Allium sativum using computational analysis." F1000Research 12 (February 9, 2023): 151. http://dx.doi.org/10.12688/f1000research.130105.1.

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Introduction: Use of natural products for management of diseases has increased widely due to the belief that natural products are less toxic than conventional medicines. Natural products have been utilised for management of chronic diseases such as diabetes and cancers. Respiratory infections have also been managed using natural products. Allium sativum is one of the natural products that has been utilised in the management of SARS-CoV infections, diabetes and cancer. Methods: This study was aimed at screening bioactive agents in Allium sativum using computational analysis. The targets of the bioactive agents were predicted using SwissTargetPrediction tools. Molecular docking followed, where the docking energies of the bioactive agents to the targets were generated. The bioactive agents were analysed for pharmacokinetics properties using SwissADME as well as toxicity profiles using the ProTox II webserver. The docking scores, toxicities and pharmacokinetics profiles of the bioactive agents in Allium sativum were compared with those of reference compounds. Results: All the bioactives showed lower docking scores than the reference compounds. The bioactives, however, showed some activity on specific receptors such as carbonic anhydrases, cyclooxygenase and ghrelin. All the bioactives showed high gastrointestinal tract absorption and none violated Lipinski’s rule of five. Diallyl trisulphide was predicted to be most lethal, with an LD50 of 100mg/kg, while was the safest, with 8000mg/kg. Conclusions: In conclusion, bioactives showed lower docking scores than the reference compounds, therefore overall pharmacological activity could be attributed to synergy between the bioactives for a particular receptor.
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Kagnou, Hèzouwè, Oudjaniyobi Simalou, Gneiny Whad Tchani, Sabrina Sanvee, Kokou Agbékonyi Agbodan, Outéndé Toundou, and Kafui Kpegba. "Etude phytochimique et activité antioxydante comparatives des trois variétés de Catharanthus roseus (L.) G. Don." International Journal of Biological and Chemical Sciences 14, no. 6 (October 7, 2020): 2352–61. http://dx.doi.org/10.4314/ijbcs.v14i6.33.

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Catharanthus roseus (L.) G. Don, est une plante médicinale largement utilisée en tradithérapie contre le diabète, l’hypertension, le cancer et les effets du stress oxydatif. Elle existe en trois variétés ("rosea", "alba" et "hybride") selon la couleur des fleurs. L’étude actuelle porte sur le criblage phytochimique et l’activité antioxydante in vitro (DPPH et FRAP) de l’extrait hydro-éthanolique des trois variétés. Les tests ont été effectués sur les extraits des feuilles, fleurs et racines. On a noté la présence des alcaloïdes, phénols, flavonoïdes, tanins, saponines, stérols, terpènes et quinines. Cependant, l’absence des sucres réducteurs, des flavonoïdes et des saponines dans les racines ainsi que les quinines dans les feuilles a été relevée. L'analyse comparative par piégeage du radical DPPH a montré que les extraits des fleurs et racines de l’hybride étaient plus actifs, respectivement de 130,023±3,2 et 131,189±1,8 mg EqQ/g. Une tendance différente a été observée dans les extraits des feuilles où la meilleure valeur DPPH de 65,746±2,5 mg EqQ/g est attribuée à "rosea" alors que celle du FRAP de 139,935±2,57 mg EqAA/g provient de "alba". Ces résultats devraient encourager la poursuite des travaux sur l'identification et la caractérisation de nouveaux composés bioactifs sélectivement abondant pour une meilleure valorisation de Catharanthus roseus sur le plan de phytomédicaments.Mots clés : Catharanthus roseus, variétés, criblage phytochimique, antioxydant. English Title: Phytochemical study and comparative antioxidant activity of the three varieties of Catharanthus roseus (L.) G. DonCatharanthus roseus (L.) G. Don, is a medicinal plant widely used in the treatment of diabetes, hypertension, cancer, and effects of oxidative stress. C. roseus exists in three varieties ("rosea", "alba" and "hybrid") depending on the colour of the flowers. This study focused on phytochemical screening and in vitro antioxidant activity (DPPH and FRAP) of the hydro-ethanol extract of the three varieties. The tests were carried out on leaves, flowers, and roots extracts. The presence of alkaloids, phenols, flavonoids, tannins, saponins, sterols, terpenes, and quinines were noted. However, the absence of reducing sugars, flavonoids, and saponins in the roots and quinines in the leaves was observed. Comparative analysis of DPPH radical scavenging showed that extracts from the flowers and roots of the hybrid were more active, respectively at 130.023±3.2 and 131.189±1.8 mg EqQ/g. FRAP values of the same samples were 175.166± 9.28 and 121.311±7.8 mg EqAA/g dry matter. For the leaves, the best DPPH value of 65.746±2.5 mg EqQ/g was attributed to "rosea" while the FRAP value of 139.935±2.57 mg EqAA/g was for "alba". These interesting antioxidant activities of the "hybrid" variety may be useful against oxidative stress pathologies. The current study might then promote the continuing identification and characterization of new bioactive compounds for a development of Catharanthus roseus.Keywords: Catharanthus roseus, varieties, phytochemical screening, antioxidant.
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Bordoni, A., C. Boesch, C. Malpuech-Brugère, C. Orfila, and L. Tomás-Cobos. "The role of bioactives in energy metabolism and metabolic syndrome." Proceedings of the Nutrition Society 78, no. 3 (April 10, 2019): 340–50. http://dx.doi.org/10.1017/s0029665119000545.

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Some food bioactives potentially exert anti-obesity effects. Anthocyanins (ACN), catechins, β-glucan (BG) and n-3 long chain PUFA (LCPUFA) are among the most promising candidates and have been considered as a strategy for the development of functional foods counteracting body weight gain. At present, clinical trials, reviews and meta-analyses addressing anti-obesity effects of various bioactives or bioactive-rich foods show contradictory results. Abdominal obesity is an important criterion for metabolic syndrome (MetS) diagnosis along with glucose intolerance, dyslipidaemia and hypertension. Food bioactives are supposed to exert beneficial effects on these parameters, therefore representing alternative therapy approaches for the treatment of MetS. This review summarises outcomes on MetS biomarkers in recent clinical trials supplementing ACN, catechins, BG and n-3 LCPUFA, focusing mainly on anti-obesity effects. Overall, it is clear that the level of evidence for the effectiveness varies not only among the different bioactives but also among the different putative health benefits suggested for the same bioactive. Limited evidence may be due to the low number of controlled intervention trials or to inconsistencies in trial design, i.e. duration, dose and/or the method of bioactive supplementation (extracts, supplements, rich or enriched food). At present, the question ‘Are bioactives effective in weight management and prevention of metabolic syndrome?’ remains inconclusive. Thus, a common effort to harmonise the study design of intervention trials focusing on the most promising bioactive molecules is urgently needed to strengthen the evidence of their potential in the treatment of obesity, MetS and related diseases.
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Yates, Allison A., Johanna T. Dwyer, John W. Erdman, Janet C. King, Barbara J. Lyle, Barbara O. Schneeman, and Connie M. Weaver. "Perspective: Framework for Developing Recommended Intakes of Bioactive Dietary Substances." Advances in Nutrition 12, no. 4 (May 7, 2021): 1087–99. http://dx.doi.org/10.1093/advances/nmab044.

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ABSTRACT Dietary bioactives are food substances that promote health but are not essential to prevent typical deficiency conditions. Examples include lutein and zeaxanthin, omega-3 fatty acids, and flavonoids. When quality evidence is available, quantified intake recommendations linking dietary bioactives with specific health benefits will enable health professionals to provide evidence-based information to consumers. Without evidence-based recommendations, consumers use information from available sources that often lack standards and rigor. This article describes a framework to develop guidance based on quality evidence fully vetted for efficacy and safety by qualified experts, and designed to communicate the amounts of specific dietary bioactive compounds with identified health benefits. The 4-step Framework described here can be adapted by credible health organizations to work within their guideline development process. Standards of practice used in clinical guidelines are adapted to quantify dietary bioactive intake recommendations from foods consumed by the general public, by taking into account that side effects and trade-offs are often needed for medical treatments but are not acceptable for dietary bioactives. In quantifying dietary bioactive recommendations, this Framework establishes 4 decision-making steps: 1) characterize the bioactive, determine amounts in specific food sources, and quantify intakes; 2) evaluate safety; 3) quantify the causal relation between the specific bioactive and accepted markers of health or normal function via systematic evidence reviews; and 4) translate the evidence into a quantified bioactive intake statement. This Framework provides a working model that can be updated as new approaches are advanced.
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Postružnik, Vesna, Slađana Stajčić, Dragana Borjan, Gordana Ćetković, Željko Knez, Maša Knez Marevci, and Jelena Vulić. "Impact of Storage Conditions on Stability of Bioactive Compounds and Bioactivity of Beetroot Extract and Encapsulates." Processes 12, no. 7 (June 28, 2024): 1345. http://dx.doi.org/10.3390/pr12071345.

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(1) Background: In this study, bioactive compounds (phenolics and betalains) extracted from beetroot were stabilized by encapsulation with maltodextrin and soy protein by the freeze drying method. Stability of bioactive compounds and bioactivities in a beetroot extract and encapsulates during 60 days of storage at 4 °C (without light) and at 25 °C (with and without light) were investigated. (2) Methods: Contents of bioactive compounds and bioactivity (antioxidant activity by DPPH, RP, and ABTS tests; anti-inflammatory and antihyperglycemic activity) were determined. Improvement in stability of bioactives’ content and bioactivity of prepared encapsulates in relation to the extract was observed after storage at room temperature under light conditions. (3) Results: Encapsulation with maltodextrin showed improvement in stability of all studied bioactive parameters, while an encapsulate with soy protein improved stability of bioactives and antioxidant activity compared to the extract. The encapsulated beetroot extract represents a promising food additive for functional foods due to their content of bioactive compounds and consequent bioactivities.
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Evans, Levi W., Samantha S. Romanick, and Bradley S. Ferguson. "Natural product inhibitors of acetyl-lysine erasers in the prevention and treatment of heart failure." Functional Foods in Health and Disease 7, no. 8 (August 31, 2017): 577. http://dx.doi.org/10.31989/ffhd.v7i8.376.

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Background: Heart failure (HF) is a major public health concern, with five-year mortality rates following first admission for HF being approximately 50%, thereby stressing the need for novel therapeutic approaches. Histone deacetylases (HDACs) govern lysine acetylation of histone tails that regulates nucleosmal DNA. HDAC inhibitors have emerged as efficacious therapies in pre-clinical models of HF. Interest in diet-gene interactions has given rise to the study of ‘food bioactives’ as epigenetic regulators of gene expression that control human health and disease. These reports demonstrate that bioactive food compounds regulate epigenetic marks that link diet to gene regulation. In fact, others have also shown that bioactive compounds can target HDACs for inhibition; accordingly, bioactive food compounds offer unique opportunities for therapeutic intervention and prevention of heart failure. Lastly, there is emerging interest into how these food bioactives function together or as additives within foods ‘functional foods’ to regulate epigenetic disease. This review will highlight bioactive compound HDAC inhibitors and their role in the heart.Keywords: acetylation, bioactive compounds, dietary HDAC inhibitors, HDACs, histone deacetylases
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Cecchi, Nicola, Roberta Romanelli, Flavia Ricevuti, Maria Grazia Carbone, Michele Dinardo, Elisabetta Cesarano, Alfredo De Michele, et al. "Bioactives in Oral Nutritional Supplementation: A Pediatric Point of View." Nutrients 16, no. 13 (June 28, 2024): 2067. http://dx.doi.org/10.3390/nu16132067.

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Background: Oral nutritional supplements (ONSs) are crucial for supporting the nutritional needs of pediatric populations, particularly those with medical conditions or dietary deficiencies. Bioactive compounds within ONSs play a pivotal role in enhancing health outcomes by exerting various physiological effects beyond basic nutrition. However, the comprehensive understanding of these bioactives in pediatric ONSs remains elusive. Objective: This systematic narrative review aims to critically evaluate the existing literature concerning bioactive compounds present in oral nutritional supplements from a pediatric standpoint, focusing on their types, sources, bioavailability, physiological effects, and clinical implications. Methods: A systematic search was conducted across the major academic databases, including PubMed, Scopus, and Web of Science, employing predefined search terms related to oral nutritional supplements, bioactives, and pediatrics. Studies published between 2013 and 2024 were considered eligible for inclusion. Data extraction and synthesis were performed according to the PRISMA guidelines. Results: The initial search yielded 558 of articles, of which 72 met the inclusion criteria. The included studies encompassed a diverse range of bioactive compounds present in pediatric ONS formulations, including, but not limited to, vitamins, minerals, amino acids, prebiotics, probiotics, and phytonutrients. These bioactives were sourced from various natural and synthetic origins and were found to exert beneficial effects on growth, development, immune function, gastrointestinal health, cognitive function, and overall well-being in pediatric populations. However, variations in bioavailability, dosing, and clinical efficacy were noted across different compounds and formulations. Conclusions: Bioactive compounds in oral nutritional supplements offer promising avenues for addressing the unique nutritional requirements and health challenges faced by pediatric populations. However, further research is warranted to elucidate the optimal composition, dosage, and clinical applications of these bioactives in pediatric ONS formulations. A deeper understanding of these bioactive compounds and their interplay with pediatric health may pave the way for personalized and effective nutritional interventions in pediatric clinical practice.
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Kussmann, Martin, and David Henrique Abe Cunha. "Nature has the answers: Discovering and validating natural bioactives for human health." Bioactive Compounds in Health and Disease 5, no. 10 (November 4, 2022): 222. http://dx.doi.org/10.31989/bchd.v5i10.1000.

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Nature has the answer to many of our questions about human health. Natural bioactives, especially when derived from sustainable plant and food sources, provide a plethora of molecular solutions to nutritionally actionable, chronic conditions. The spectrum of these conditions, such as metabolic, immune, and gastrointestinal disorders, has changed with prolonged human life span, which should be matched with an appropriately extended health span: “adding years to life and adding life to years”. Natural bioactives can be classified into micronutrients (i.e., vitamins, and minerals), phytonutrients, bioactive peptides,and pre-, pro-, post- and synbiotics. Bioactives act in concert and interact with the human host and its (gut) microbiome. Therefore, the future of translational science on natural bioactives is being built on a: (a) systems-level rather than reductionist approaches to understanding their interdependent, and at times additive functions, as well as their interactions with the human host and (gut) microbiome; and (b) the leverage of artificial intelligence for discovery and validation, thereby substantially reducing the time from idea and concept to finished solutions for consumers and patients. Rather than focusing on a particular class of bioactive food molecules, as often done in molecular food and nutrition articles, this review embraces a broad range of these bioactives and puts them into perspective regarding a more efficient and sustainable leverage of the biochemical richness of plants and foods for its diverse positive effects on human health.Keywords: bioactive, micronutrient, phytonutrient, prebiotic, probiotic, synbiotic, peptide, artificial intelligence, discovery, validation
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Ibarra, Ernesto A., Raul Adames, Jorge Castro, Sofia Guevara, Luis Estrada Petrocelli, Diego Reginensi, Jay Molino, and Mahelys Vasquez. "Avances en Biocerámicas para la Regeneración Ósea: De Materiales Bioinertes a Compuestos Bioactivos." European Scientific Journal, ESJ 20, no. 15 (May 31, 2024): 1. http://dx.doi.org/10.19044/esj.2024.v20n15p1.

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Este artículo ofrece una revisión sistemática de la evolución de los biomateriales cerámicos utilizados en la regeneración de tejido óseo, desde cerámicas tradicionales bioinertes hasta biocerámicas bioactivas y reabsorbibles. La metodología incluyó una revisión exhaustiva de la literatura utilizando bases de datos principales como PubMed, Scopus, Web of Science, y Google Scholar. Se aplicaron estrategias de búsqueda detalladas con palabras clave específicas y operadores booleanos, seleccionando estudios que aportaban directamente al entendimiento del desarrollo y aplicaciones de biocerámicas en la regeneración ósea. La transición de materiales como la alúmina y la zirconia hacia compuestos más avanzados como el fosfato de calcio y el vidrio bioactivo es analizada en detalle. Se discute cómo estas generaciones sucesivas han mejorado la interacción con el tejido óseo, desde la simple osteointegración hasta la facilitación de la osteogénesis y angiogénesis. Se enfatiza la importancia de la microestructura y la composición química en la eficacia de la integración de estos materiales con el tejido óseo, incluyendo el impacto de la porosidad y la superficie superficial en la respuesta biológica. Adicionalmente, se examina el papel de las últimas innovaciones en biocerámicas, como aquellas que ofrecen liberación controlada de fármacos y agentes bioactivos en la mejora de los resultados de la regeneración ósea. Este trabajo subraya la relevancia de un enfoque interdisciplinario en la investigación de biomateriales, combinando conocimientos de la biología ósea, la química de materiales, y la ingeniería de tejidos para el diseño de soluciones más efectivas y personalizadas en la regeneración de tejido óseo. This article provides a systematic review of the evolution of ceramic biomaterials used in bone tissue regeneration, from traditional bioinert ceramics to bioactive and resorbable bioceramics. The methodology included a comprehensive literature review using major databases such as PubMed, Scopus, Web of Science, and Google Scholar. Detailed search strategies with specific keywords and Boolean operators were applied, selecting studies that directly contribute to the understanding of the development and applications of bioceramics in bone regeneration. The transition from materials such as alumina and zirconia to more advanced compounds like calcium phosphate and bioactive glass is analyzed in detail. It discusses how these successive generations have improved interaction with bone tissue, from simple osteointegration to facilitating osteogenesis and angiogenesis. The importance of microstructure and chemical composition in the effectiveness of integrating these materials with bone tissue is emphasized, including the impact of porosity and surface area on the biological response. Additionally, the role of the latest innovations in bioceramics, such as those offering controlled release of drugs and bioactive agents in improving bone regeneration outcomes, is examined. This work highlights the relevance of an interdisciplinary approach in biomaterials research, combining knowledge from bone biology, materials chemistry, and tissue engineering to design more effective and personalized solutions in bone tissue regeneration.
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Sharma, Manoj B., Hend A. M. Abdelmohsen, Özlem Kap, Volkan Kilic, Nesrin Horzum, David Cheneler, and John G. Hardy. "Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release." Bioengineering 11, no. 7 (June 25, 2024): 649. http://dx.doi.org/10.3390/bioengineering11070649.

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Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.
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Jin, Juri, Md Helal Uddin Chowdhury, Md Hafizur Rahman, Ki-Young Choi, and Md Adnan. "Bioactive Compounds and Signaling Pathways of Wolfiporia extensa in Suppressing Inflammatory Response by Network Pharmacology." Life 13, no. 4 (March 27, 2023): 893. http://dx.doi.org/10.3390/life13040893.

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Wolfiporia extensa (WE) is a medicinal mushroom and an excellent source of naturally occurring anti-inflammatory substances. However, the particular bioactive compound(s) and mechanism(s) of action against inflammation have yet to be determined. Here, we studied anti-inflammatory bioactive compounds and their molecular mechanisms through network pharmacology. Methanol (ME) extract of WE (MEWE) was used for GC-MS analysis to identify the bioactives, which were screened by following Lipinski’s rules. Public databases were used to extract selected bioactives and inflammation-related targets, and Venn diagrams exposed the common targets. Then, STRING and Cytoscape tools were used to construct protein-protein (PPI) network and mushroom-bioactives-target (M-C-T) networks. Gene Ontology and KEGG pathway analysis were performed by accessing the DAVID database and molecular docking was conducted to validate the findings. The chemical reactivity of key compounds and standard drugs was explored by the computational quantum mechanical modelling method (DFT study). Results from GC-MS revealed 27 bioactives, and all obeyed Lipinski’s rules. The public databases uncovered 284 compound-related targets and 7283 inflammation targets. A Venn diagram pointed to 42 common targets which were manifested in the PPI and M-C-T networks. KEGG analysis pointed to the HIF-1 signaling pathway and, hence, the suggested strategy for preventing the onset of inflammatory response was inhibition of downstream NFKB, MAPK, mTOR, and PI3K-Akt signaling cascades. Molecular docking revealed the strongest binding affinity for “N-(3-chlorophenyl) naphthyl carboxamide” on five target proteins associated with the HIF-1 signaling pathway. Compared to the standard drug utilized in the DFT (Density Functional Theory) analysis, the proposed bioactive showed a good electron donor component and a reduced chemical hardness energy. Our research pinpoints the therapeutic efficiency of MEWE and this work suggests a key bioactive compound and its action mechanism against inflammation.
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Cruz-Martins, Natália, Cristina Quispe, Celale Kırkın, Ezgi Şenol, Aslı Zuluğ, Beraat Özçelik, Adedayo O. Ademiluyi, et al. "Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder." Oxidative Medicine and Cellular Longevity 2021 (August 21, 2021): 1–17. http://dx.doi.org/10.1155/2021/1131280.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.
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El-Ramady, Hassan, Peter Hajdú, Gréta Törős, Khandsuren Badgar, Xhensila Llanaj, Attila Kiss, Neama Abdalla, et al. "Plant Nutrition for Human Health: A Pictorial Review on Plant Bioactive Compounds for Sustainable Agriculture." Sustainability 14, no. 14 (July 7, 2022): 8329. http://dx.doi.org/10.3390/su14148329.

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Is there any relationship between plant nutrition and human health? The overall response to this question is very positive, and a strong relationship between the nutrition of plants and humans has been reported in the literature. The nutritional status of edible plants consumed by humans can have a negative or positive impact on human health. This review was designed to assess the importance of plant bioactive compounds for human health under the umbrella of sustainable agriculture. With respect to the first research question, it was found that plant bioactives (e.g., alkaloids, carotenoids, flavonoids, phenolics, and terpenoids) have a crucial role in human health due to their therapeutic benefits, and their potentiality depends on several factors, including botanical, environmental, and clinical attributes. Plant bioactives could be produced using plant tissue culture tools (as a kind of agro-biotechnological method), especially in cases of underexploited or endangered plants. Bioactive production of plants depends on many factors, especially climate change (heat stress, drought, UV radiation, ozone, and elevated CO2), environmental pollution, and problematic soils (degraded, saline/alkaline, waterlogged, etc.). Under the previously mentioned stresses, in reviewing the literature, a positive or negative association was found depending on the kinds of stress or bioactives and their attributes. The observed correlation between plant bioactives and stress (or growth factors) might explain the importance of these bioactives for human health. Their accumulation in stressed plants can increase their tolerance to stress and their therapeutic roles. The results of this study are in keeping with previous observational studies, which confirmed that the human nutrition might start from edible plants and their bioactive contents, which are consumed by humans. This review is the first report that analyzes this previously observed relationship using pictorial presentation.
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Ramadan, Mohamed Fawzy, Alessandra Durazzo, and Massimo Lucarini. "Advances in Research on Food Bioactive Molecules and Health." Molecules 26, no. 24 (December 19, 2021): 7678. http://dx.doi.org/10.3390/molecules26247678.

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Fresh and processed food products are rich in bioactive molecules, including polysaccharides, vitamins, carotenoids, peptides, antioxidants, phenolics, phytosterols, and novel lipids. Bioactive molecules in food could prevent several diseases (i.e., metabolic syndrome, cardiovascular diseases, cancer, etc.). Thus, consumer awareness is growing about the health-promoting impact of food bioactive molecules. Health claims are essential added-value features, wherein health-enhancing potential of bioactives depend on their chemical structure. On the other hand, the investigation of the structure-function relationship of food bioactive molecules is of importance. In this regard, Molecules is delighted to highlight the importance of food bioactive molecules and their effect on health. In this Special Issue of Molecules, researchers are invited to contribute original research and up-to-date reviews.
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Ruiz Flores, Gabriel, Maricela Quiroz-Bravo, Mario Márquz Lemus, Diana Maylet Hernández-Martínez, and Ma del Socorro López-Cortez. "Effect of Processing Stage on the Bioactives of Tomato Purees Supplemented Preserved by Microwaves." Journal of the Mexican Chemical Society 67, no. 2 (April 1, 2023): 103–21. http://dx.doi.org/10.29356/jmcs.v67i2.1877.

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Abstract. Tomatoes are a natural source of bioactive compounds. Most of these substances accumulate in the tomato skin and seeds and are scarce in the pulp, which is the main ingredient of tomato products. The application of technological processes as well as plant variety, cultivation, and harvesting conditions, can significantly affect the content and composition of phenolics in tomato fruit and tomato-based products. To increase the content of bioactive, in the present investigation a tomato puree supplemented with the seeds and skin of the fruit was prepared using tomatoes of Mexican origin. The bioactive compounds at each stage of the process were evaluated. The variation in bioactive compounds occurred during the tomato juice concentration stage. The retention of bioactive compounds was similar when conventional pasteurization and microwave treatment were applied independently, however, the microwave used a lower time. Tomato puree supplemented with seeds and skin presented a higher content of bioactive. There were no significant differences in the microbiological activity between pasteurization and microwave treatment since both heat treatments achieved similar microbial inactivation. Chlorogenic acid, rutin, resveratrol, quercetin, and naringenin were identified by HPLC. The microwave-treated tomato puree presented a less acidic taste, a more intense red color, and a more pleasant aroma compared to the pasteurized tomato puree. The PCA analysis showed that the processing stages that affect the polyphenolic content in the elaboration of tomato purees corresponded to the heat treatments appliednd and the concentration stage. Resumen. Los tomates son una fuente natural de bioactivos. La mayoría de estas sustancias se acumulan en la piel y las semillas del tomate y son escasas en la pulpa, que es el ingrediente principal de los productos derivados del tomate. La aplicación de procesos tecnológicos, así como la variedad de plantas, el cultivo y las condiciones de cosecha, pueden afectar significativamente el contenido y la composición de compuestos fenólicos en el fruto del tomate y los productos a base de tomate. Para aumentar el contenido de bioactivos, en la presente investigación se preparó un puré de tomate suplementado con las semillas y la piel del fruto utilizando tomates de origen mexicano. Se evaluaron los compuestos bioactivos en cada etapa del proceso. La variación de los compuestos bioactivos ocurrió durante la etapa de concentración del jugo de tomate. La retención de compuestos bioactivos fue similar cuando la pasteurización convencional y el tratamiento con microondas se aplicaron de forma independiente, sin embargo, el microondas usó un tiempo menor. El puré de tomate suplementado con semillas y piel presentó mayor contenido de bioactivos. No hubo diferencias significativas en la actividad microbiológica entre la pasteurización y el tratamiento con microondas ya que ambos tratamientos térmicos lograron una inactivación microbiana similar. Por HPLC se identificaron ácido clorogénico, rutina, resveratrol, quercetina y naringenina. El puré de tomate tratado con microondas presentó un sabor menos ácido, un color rojo más intenso y un aroma más agradable en comparación con el puré de tomate pasteurizado. El análisis PCA mostró que las etapas de procesamiento que inciden en el contenido polifenólico en la elaboración de purés de tomate correspondieron a los tratamientos térmicos aplicados y la etapa de concentración.
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Sadiq, Uzma, Harsharn Gill, and Jayani Chandrapala. "Casein Micelles as an Emerging Delivery System for Bioactive Food Components." Foods 10, no. 8 (August 23, 2021): 1965. http://dx.doi.org/10.3390/foods10081965.

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Bioactive food components have potential health benefits but are highly susceptible for degradation under adverse conditions such as light, pH, temperature and oxygen. Furthermore, they are known to have poor solubilities, low stabilities and low bioavailabilities in the gastrointestinal tract. Hence, technologies that can retain, protect and enable their targeted delivery are significant to the food industry. Amongst these, microencapsulation of bioactives has emerged as a promising technology. The present review evaluates the potential use of casein micelles (CMs) as a bioactive delivery system. The review discusses in depth how physicochemical and techno-functional properties of CMs can be modified by secondary processing parameters in making them a choice for the delivery of food bioactives in functional foods. CMs are an assembly of four types of caseins, (αs1, αs2, β and κ casein) with calcium phosphate. They possess hydrophobic and hydrophilic properties that make them ideal for encapsulation of food bioactives. In addition, CMs have a self-assembling nature to incorporate bioactives, remarkable surface activity to stabilise emulsions and the ability to bind hydrophobic components when heated. Moreover, CMs can act as natural hydrogels to encapsulate minerals, bind with polymers to form nano capsules and possess pH swelling behaviour for targeted and controlled release of bioactives in the GI tract. Although numerous novel advancements of employing CMs as an effective delivery have been reported in recent years, more comprehensive studies are required to increase the understanding of how variation in structural properties of CMs be utilised to deliver bioactives with different physical, chemical and structural properties.
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Oh, Ki Kwang, Md Adnan, and Dong Ha Cho. "Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout." International Journal of Molecular Sciences 22, no. 17 (August 29, 2021): 9372. http://dx.doi.org/10.3390/ijms22179372.

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M. alba L. is a valuable nutraceutical plant rich in potential bioactive compounds with promising anti-gouty arthritis. Here, we have explored bioactives, signaling pathways, and key proteins underlying the anti-gout activity of M. alba L. leaves for the first-time utilizing network pharmacology. Bioactives in M. alba L. leaves were detected through GC-MS (Gas Chromatography-Mass Spectrum) analysis and filtered by Lipinski’s rule. Target proteins connected to the filtered compounds and gout were selected from public databases. The overlapping target proteins between bioactives-interacted target proteins and gout-targeted proteins were identified using a Venn diagram. Bioactives-Proteins interactive networking for gout was analyzed to identify potential ligand-target and visualized the rich factor on the R package via the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway on STRING. Finally, a molecular docking test (MDT) between bioactives and target proteins was analyzed via AutoDock Vina. Gene Set Enrichment Analysis (GSEA) demonstrated that mechanisms of M. alba L. leaves against gout were connected to 17 signaling pathways on 26 compounds. AKT1 (AKT Serine/Threonine Kinase 1), γ-Tocopherol, and RAS signaling pathway were selected as a hub target, a key bioactive, and a hub signaling pathway, respectively. Furthermore, three main compounds (γ-Tocopherol, 4-Dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine, and Lanosterol acetate) and three key target proteins—AKT1, PRKCA, and PLA2G2A associated with the RAS signaling pathway were noted for their highest affinity on MDT. The identified three key bioactives in M. alba L. leaves might contribute to recovering gouty condition by inactivating the RAS signaling pathway.
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