Relevant bibliographies by topics / Bio-molecules detection / Journal articles

Journal articles on the topic 'Bio-molecules detection'

To see the other types of publications on this topic, follow the link: Bio-molecules detection.
Author: Grafiati
Published: 11 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Bio-molecules detection.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Singh, Ravindra P. "Bio- Nanomaterials For Versatile Bio- Molecules Detection Technology." Advanced Materials Letters 1, no. 1 (April 1, 2010): 83–84. http://dx.doi.org/10.5185/amlett.2010.4109.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Yoo, Kyung-Ah, Kwang Ho Na, Seung-Ryong Joung, D. Jeon, Y. J. Choi, Yong Sang Kim, and C. J. Kang. "Characterization of a Piezoresistive Microcantilever as a Sensor for Detecting the Bio-Molecules." Materials Science Forum 510-511 (March 2006): 1090–93. http://dx.doi.org/10.4028/www.scientific.net/msf.510-511.1090.

Full text
Abstract:
We propose an electrical detection method for detecting the various bio-molecules effectively with microcantilevers. The piezoresistive microcantilevers were fabricated employing surface micromachining technique that has attractive advantages in terms of cost efficiency, simplicity, and ability of fabricating in array. The fluid cell system for injection of bio-molecular solution is fabricated using polydimethylsiloxane (PDMS) and a fused silica glass. The microcantilever is deflected with respect to the difference of the surface stress caused by the formation of self-assembled bio-molecules on the gold coated side of the microcantilever. We confirmed that the deflections occurred by the bio-molecule adsorption and microcantilever can be widely used to a &-TAS and a lab-on-a-chip as a sensor for the potential detection of various biomolecules.
APA, Harvard, Vancouver, ISO, and other styles
3

Yang, Zhiyong, Megan K. Fah, Kelly A. Reynolds, Jonathan D. Sexton, Mark R. Riley, Marie-Laure Anne, Bruno Bureau, and Pierre Lucas. "Opto-electrophoretic detection of bio-molecules using conducting chalcogenide glass sensors." Optics Express 18, no. 25 (December 6, 2010): 26754. http://dx.doi.org/10.1364/oe.18.026754.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Szalkowski, Marcin, Khuram U. Ashraf, Heiko Lokstein, Sebastian Mackowski, Richard J. Cogdell, and Dorota Kowalska. "Silver island film substrates for ultrasensitive fluorescence detection of (bio)molecules." Photosynthesis Research 127, no. 1 (July 14, 2015): 103–8. http://dx.doi.org/10.1007/s11120-015-0178-x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Anderson, Mark. "The Detection of Long-Chain Bio-Markers Using Atomic Force Microscopy." Applied Sciences 9, no. 7 (March 27, 2019): 1280. http://dx.doi.org/10.3390/app9071280.

Full text
Abstract:
The detection of long-chain biomolecules on mineral surfaces is presented using an atomic force microscope (AFM). This is achieved by using the AFM’s ability to manipulate molecules and measure forces at the pico-newton scale. We show that a highly characteristic force-distance signal is produced when the AFM tip is used to detach long-chain molecules from a surface. This AFM force spectroscopy method is demonstrated on bio-films, spores, fossils and mineral surfaces. The method works with AFM imaging and correlated tip enhanced infrared spectroscopy. The use of AFM force spectroscopy to detect this class of long chain bio-markers has applications in paleontology, life detection and planetary science.
APA, Harvard, Vancouver, ISO, and other styles
6

Lin, I. En, Yi Ling Ye, Ding Yuan Liang, and Bang Wei Chen. "Theoretical and Experimental Studies of Bio-Detection Areas Used in Centrifugal Microfluidic Platforms." Advanced Materials Research 647 (January 2013): 386–90. http://dx.doi.org/10.4028/www.scientific.net/amr.647.386.

Full text
Abstract:
The CD-ELISA is a self-contained micro-device that incorporates low-power micro-fluidic components and high-sensitivity immune-molecules, and is capable of performing parallel and multiple tests with high precision. The CD platform integrates number of micro-fluidic functions. Bio-detection area is the most important region which directly affects measurement results. In this study, both theoretical and experimental results were compared to show the feasibility design of bio-detection region.
APA, Harvard, Vancouver, ISO, and other styles
7

Eisele, J. A., D. D. Fowler, G. Haynes, and R. A. Lewis. "Survival and detection of blood residues on stone tools." Antiquity 69, no. 262 (March 1995): 36–46. http://dx.doi.org/10.1017/s0003598x00064280.

Full text
Abstract:
A new field is opening up in biological archaeology, as it is found that ancient DNA and other bio-molecules may–under the right conditions–survive over the long term. Is the same true of blood residues on stone tools?
APA, Harvard, Vancouver, ISO, and other styles
8

da Silva, Jailson J., Wedja M. dos Santos, Rafael da S. Fernandes, Adriana Fontes, Beate S. Santos, Claudete F. Pereira, Patrick Krebs, Boris Mizaikoff, Goreti Pereira, and Giovannia A. L. Pereira. "A facile route toward hydrophilic plasmonic copper selenide nanocrystals: new perspectives for SEIRA applications." New Journal of Chemistry 45, no. 35 (2021): 15753–60. http://dx.doi.org/10.1039/d1nj02672k.

Full text
Abstract:
Development of versatile and efficient plasmonic nanoprobes for detection of (bio)molecules in an ultrasmall concentration, when applied as substrates in surface-enhanced infrared (SEIRA) spectroscopy.
APA, Harvard, Vancouver, ISO, and other styles
9

Jia, Hao, Pengcheng Xu, and Xinxin Li. "Integrated Resonant Micro/Nano Gravimetric Sensors for Bio/Chemical Detection in Air and Liquid." Micromachines 12, no. 6 (May 31, 2021): 645. http://dx.doi.org/10.3390/mi12060645.

Full text
Abstract:
Resonant micro/nanoelectromechanical systems (MEMS/NEMS) with on-chip integrated excitation and readout components, exhibit exquisite gravimetric sensitivities which have greatly advanced the bio/chemical sensor technologies in the past two decades. This paper reviews the development of integrated MEMS/NEMS resonators for bio/chemical sensing applications mainly in air and liquid. Different vibrational modes (bending, torsional, in-plane, and extensional modes) have been exploited to enhance the quality (Q) factors and mass sensing performance in viscous media. Such resonant mass sensors have shown great potential in detecting many kinds of trace analytes in gas and liquid phases, such as chemical vapors, volatile organic compounds, pollutant gases, bacteria, biomarkers, and DNA. The integrated MEMS/NEMS mass sensors will continuously push the detection limit of trace bio/chemical molecules and bring a better understanding of gas/nanomaterial interaction and molecular binding mechanisms.
APA, Harvard, Vancouver, ISO, and other styles
10

Palanna, Manjunatha, Imadadulla Mohammed, Shambhulinga Aralekallu, Manjunatha Nemakal, and Lokesh Koodlur Sannegowda. "Simultaneous detection of paracetamol and 4-aminophenol at nanomolar levels using biocompatible cysteine-substituted phthalocyanine." New Journal of Chemistry 44, no. 4 (2020): 1294–306. http://dx.doi.org/10.1039/c9nj05252f.

Full text
APA, Harvard, Vancouver, ISO, and other styles
11

Myndrul, Valerii, and Igor Iatsunskyi. "Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives." Materials 12, no. 18 (September 6, 2019): 2880. http://dx.doi.org/10.3390/ma12182880.

Full text
Abstract:
This review highlights the application of different types of nanosilicon (nano-Si) materials and nano-Si-based composites for (bio)sensing applications. Different detection approaches and (bio)functionalization protocols were found for certain types of transducers suitable for the detection of biological compounds and gas molecules. The importance of the immobilization process that is responsible for biosensor performance (biomolecule adsorption, surface properties, surface functionalization, etc.) along with the interaction mechanism between biomolecules and nano-Si are disclosed. Current trends in the fabrication of nano-Si-based composites, basic gas detection mechanisms, and the advantages of nano-Si/metal nanoparticles for surface enhanced Raman spectroscopy (SERS)-based detection are proposed.
APA, Harvard, Vancouver, ISO, and other styles
12

Chang, Minmin, Tao Song, Xinxin Liu, Qixuan Lin, Bei He, and Junli Ren. "Cellulose-based Biosensor for Bio-molecules Detection in Medical Diagnosis: A Mini-Review." Current Medicinal Chemistry 27, no. 28 (August 6, 2020): 4593–612. http://dx.doi.org/10.2174/0929867327666200221145543.

Full text
Abstract:
Background:: Biosensors are widely applied for the detection of bio-molecules in blood glucose , cholesterol, and gene. Cellulose as the most dominating natural polymer has attracted more and more interest, especially in the field of medicine such as advanced medical diagnosis. Cellulose could endow biosensors with improved biocompatibility, biodegradability and nontoxicity, which could help in medical diagnosis. This mini-review summarizes the current development of cellulose-based biosensors as well as their applications in medical diagnosis in recent years. Methods: After reviewing recent years’ publications we can say that, there are several kinds of cellulose used in biosensors including different cellulose derivatives, bacterial cellulose and nanocellulose. Different types of cellulose-based biosensors, such as membrane, nano-cellulose and others were briefly described in addition to the detection principle. Cellulose-based biosensors were summarized as in the previous papers. The description of various methods used for preparing cellulose-based biosensors was also provided. Results: Cellulose and its derivatives with their unique chemical structure proved to be versatile materials providing a good platform for achieving immobilizing bioactive molecules in biosensors. These cellulose-based biosensors possess various desirable properties such as accuracy, sensitivity, convenience, low cost and fast response. Among them, cellulose paper-based biosensors have the advantages of low cost and easy operation. Nano-cellulose has unique properties such as a large aspect ratio, good dispersing ability and high absorption capacity. Conclusion: Cellulose displays a promising application in biosensors which could be used to detect different bio-molecules such as glucose, lactate, urea, gene, cell, amino acid, cholesterol, protein and hydroquinone. In future, the attention will be focused on designing miniaturized, multifunctional, intelligent and integrated biosensors. Creation of low cost and environmentally friendly biosensors is also very important.
APA, Harvard, Vancouver, ISO, and other styles
13

Parra, Margarita, Salvador Gil, Pablo Gaviña, and Ana M. Costero. "Mesoporous Silica Nanoparticles in Chemical Detection: From Small Species to Large Bio-Molecules." Sensors 22, no. 1 (December 30, 2021): 261. http://dx.doi.org/10.3390/s22010261.

Full text
Abstract:
A recompilation of applications of mesoporous silica nanoparticles in sensing from the last five years is presented. Its high potential, especially as hybrid materials combined with organic or bio-molecules, is shown. Adding to the multiplying effect of loading high amounts of the transducer into the pores, the selectivity attained by the interaction of the analyte with the layer decorating the material is described. Examples of the different methodologies are presented.
APA, Harvard, Vancouver, ISO, and other styles
14

Kumar Reddy, P. Pavan, S. Bhagya Lakshmi, L. Arivazhgan, J. S. Raj Kumar, and D. Nirmal. "AlGaN/GaN HEMT for highly sensitive detection of Bio-molecules using transconductance method." IOP Conference Series: Materials Science and Engineering 872 (June 27, 2020): 012048. http://dx.doi.org/10.1088/1757-899x/872/1/012048.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Di Pietrantonio, F., M. Benetti, D. Cannatà, E. Verona, A. Palla-Papavlu, J. M. Fernández-Pradas, P. Serra, M. Staiano, A. Varriale, and S. D’Auria. "A surface acoustic wave bio-electronic nose for detection of volatile odorant molecules." Biosensors and Bioelectronics 67 (May 2015): 516–23. http://dx.doi.org/10.1016/j.bios.2014.09.027.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Kumar Roy, Pradip, Abhijit Ganguly, Wei-Hsun Yang, Chien-Ting Wu, Jih-Shang Hwang, Yian Tai, Kuei-Hsien Chen, Li-Chyong Chen, and Surojit Chattopadhyay. "Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls." Biosensors and Bioelectronics 70 (August 2015): 137–44. http://dx.doi.org/10.1016/j.bios.2015.03.027.

Full text
APA, Harvard, Vancouver, ISO, and other styles
17

Yevdokimov, Y. M. "Double-stranded DNA liquid-crystalline dispersions as biosensing units." Biochemical Society Transactions 28, no. 2 (February 1, 2000): 77–81. http://dx.doi.org/10.1042/bst0280077.

Full text
Abstract:
Three different approaches to constructing bio-sensing units based on double-stranded (ds) DNA molecules, capable of detecting various biologically active compounds, are considered. The first approach is based on the abnormal optical activity of the liquid-crystalline dispersion formed from ds DNA molecules, modified by relevant physical factors or treated with biologically active compounds. The second one is based on the abnormal optical activity of the liquid-crystalline dispersions formed first from the ds DNA and then treated with coloured biologically active compounds. The third one is based on the abnormal optical activity, specific to particles of the liquid-crystalline dispersions, where the neighbouring DNA molecules are crosslinked by artifical polymeric bridges. These approaches permit the detection of biologically relevant compounds of various origins.
APA, Harvard, Vancouver, ISO, and other styles
18

Wu, Wenkai, Juergen Geist, Sebastian Beggel, Christoph Schmitz, Stefan Milz, and Katharina Sternecker. "Immunohistochemical Detection of Various Proteoglycans in the Extracellular Matrix of Zebra Mussels." Fishes 7, no. 2 (March 24, 2022): 74. http://dx.doi.org/10.3390/fishes7020074.

Full text
Abstract:
Mussels have been used as animal models for studying ecotoxicology, biomineralization, and bio-adhesion for many years. Despite a wealth of studies on their shell matrix and byssus proteins, few studies have focused on the extracellular matrix molecules in mussel soft tissues. Extracellular matrix molecules may play important roles in biomineralization, immune reaction, and tissue homeostasis. In the present study, extracellular matrix and mineralization-related molecules in zebra mussel soft tissue were immunolocalized using well-characterized monoclonal antibodies. Our results demonstrate specific immunolocalization for collagen IV, fibronectin, and keratan sulfate in hemocytes; collagen IV in peripheral nerves; and aggrecan, link protein, and collagen XVIII in foot tissue. Laminin, decorin, and osteonectin were also broadly immunolocalized in mussel soft tissues. The distributions of these extracellular matrix molecules in mussel tissues are in line with the cell-mediated shell mineralization hypothesis, providing evidence for the molecules involved in the peripheral nervous system and byssus formation, and explaining the conservation of extracellular matrix molecules during evolution. These results further contribute to establishing zebra mussels as an attractive animal model in biomedical research.
APA, Harvard, Vancouver, ISO, and other styles
19

Jing, Chao, Lei Shi, Xiaoyuan Liu, and Yi-Tao Long. "A single gold nanorod as a plasmon resonance energy transfer based nanosensor for high-sensitivity Cu(ii) detection." Analyst 139, no. 24 (2014): 6435–39. http://dx.doi.org/10.1039/c4an01456a.

Full text
Abstract:
Plasmon resonance energy transfer (PRET) has been widely applied in the detection of bio-recognition, heavy metal ions and cellular reactions with high sensitivity, based on the overlap between the plasmon resonance scattering band of nanoparticles and the absorption band of the surface-modified chromophore molecules.
APA, Harvard, Vancouver, ISO, and other styles
20

Koninti, Raj Kumar, Abhigyan Sengupta, Krishna Gavvala, Nirmalya Ballav, and Partha Hazra. "Loading of an anti-cancer drug onto graphene oxide and subsequent release to DNA/RNA: a direct optical detection." Nanoscale 6, no. 5 (2014): 2937–44. http://dx.doi.org/10.1039/c3nr06081k.

Full text
Abstract:
Sensing of bio-molecules using the fluorescence-switch/dual fluorescence property of an eminent anticancer drug, ellipticine, has been explored to directly monitor its efficient loading onto graphene oxide and subsequent release to biomolecules like DNA/RNA.
APA, Harvard, Vancouver, ISO, and other styles
21

KIESEL, PETER, OLIVER SCHMIDT, MICHAEL BASSLER, and NOBLE JOHNSON. "COMPACT OPTICAL CHARACTERIZATION PLATFORM FOR DETECTION OF BIO-MOLECULES IN FLUIDIC AND AEROSOL SAMPLES." International Journal of High Speed Electronics and Systems 18, no. 01 (March 2008): 99–108. http://dx.doi.org/10.1142/s0129156408005175.

Full text
Abstract:
An optical characterization unit based on fluorescence spectroscopy-on-a-chip is described. It comprises a compact fluidic platform that is integrated onto a chip-size spectrometer. The analyte is continuously excited within a novel waveguide. Fluorescence spectra are recorded as the analyte traverse the detection area. In order to achieve a strong interaction between excitation light and analyte we use an anti-resonant waveguide, in which the light is guided within the target-containing medium, thereby enabling a continuous excitation of a large volume. The excitation light is guided in the lower-refractive-index fluid when the light is coupled into the waveguide at an appropriate angle. Compact spectrometers can be integrated along the fluidic channel. The spectrometers are composed of a detector array which is coated with a linear variable band-pass filter. The filter converts the spectral fluorescence information into a spatially dependent signal that is analyzed by the detector array. These chip-size spectrometers are especially applicable for characterization of moving analytes.
APA, Harvard, Vancouver, ISO, and other styles
22

IMAI, Kazuhiro. "Analytical Chemical Studies on High-Performance Recognition and Detection of Bio-molecules in Life." YAKUGAKU ZASSHI 123, no. 11 (2003): 901–17. http://dx.doi.org/10.1248/yakushi.123.901.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Amit K. Shrivastava, Debanjan Das, Neeraj Varshney, and Rajarshi Mahapatra. "Transmission and detection techniques for Internet of Bio-Nano Things applications with static and mobile molecular communication: A survey." ITU Journal on Future and Evolving Technologies 2, no. 3 (July 12, 2021): 33–78. http://dx.doi.org/10.52953/gxez7259.

Full text
Abstract:
Recent studies have shown that designing communication systems at nanoscale and microscale for the Internet of Bio-Nano Things (IoBNT) applications is possible using Molecular Communication (MC), where two or multiple nodes communicate with each other by transmitting chemical molecules. The basic steps involved in MC are the transmission of molecules, propagation of molecules in the medium, and reception of the molecules at the receiver. Various transmission schemes, channel models, and detection techniques have been proposed for MC in recent years. This paper, therefore, presents an exhaustive review of the existing literature on detection techniques along with their transmission schemes under various MC setups. More specifically, for each setup, this survey includes the transmission and detection techniques under four different environments to support various IoBNT applications: (i) static transmitter and receiver in a pure-diffusive channel, (ii) static transmitter and receiver in a flow-induced diffusive channel, (iii) mobile transmitter and receiver in a pure-diffusive channel, (iv) mobile transmitter and receiver in a flow-induced diffusive channel. Also, performances and complexities of various detection schemes have been compared. Further, several challenges in detection and their possible solutions have been discussed under both static and mobile scenarios. Furthermore, some experimental works in MC are presented to show realistic transmission and detection procedures available in practice. Finally, future research directions and challenges in the practical design of the transmitter and receiver are described to realize MC for IoBNT health applications.
APA, Harvard, Vancouver, ISO, and other styles
24

Cao, Zhong, Li Xian Sun, Ting Zhou, Yong Feng Luo, Ju Lan Zeng, Shu Long, and Ji Shan Li. "Investigation on Electronic Signals for Detection of Target DNA Molecule Based on Extended Gate FET Sensing Chip." Advanced Materials Research 236-238 (May 2011): 1923–26. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.1923.

Full text
Abstract:
An electronic detection method for DNA molecules based on an extended gate field effect transistor (EGFET) sensing chip has been presented in this paper, which consists of one gold plate electrode for molecule recognition and FET part for signal transduction. The DNA probe was prepared by first immobilization of a thiolated single-stranded oligonucleotide (T1) and then an alkanethiol such as 6-hydroxy-1-hexanethiol (6-HHT) on the gold plate. A fast cyclic voltammetry (FCV) was applied to quantification of DNA molecules by using a cathodic peak around -1.3 V at a electrode reaction, corresponding to reductive desorption in strong alkali solution. By using a 70.7 mV DC voltage onto a Ag/AgCl reference electrode, the electronic signals of EGFET were applied to detection of DNA molecules and its hybridization, and the corresponding hybridization efficient was estimated to be about 37.5%. About 1 ~ 4 DNA molecules per 100 nm2 on the Au substrate of EGFET could be counted, showing a promising sensing technique for bio-molecule.
APA, Harvard, Vancouver, ISO, and other styles
25

Göransson, Jenny, Rongqin Ke, Rachel Yuan Nong, W. Mathias Howell, Anna Karman, Jan Grawé, Johan Stenberg, et al. "Rapid Identification of Bio-Molecules Applied for Detection of Biosecurity Agents Using Rolling Circle Amplification." PLoS ONE 7, no. 2 (February 22, 2012): e31068. http://dx.doi.org/10.1371/journal.pone.0031068.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Ajay, Rakhi Narang, Manoj Saxena, and Mridula Gupta. "Analysis of gate underlap channel double gate MOS transistor for electrical detection of bio-molecules." Superlattices and Microstructures 88 (December 2015): 225–43. http://dx.doi.org/10.1016/j.spmi.2015.09.013.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Pol, Laura, Chris Eckstein, Laura Acosta, Elisabet Xifré-Pérez, Josep Ferré-Borrull, and Lluis Marsal. "Real-Time Monitoring of Biotinylated Molecules Detection Dynamics in Nanoporous Anodic Alumina for Bio-Sensing." Nanomaterials 9, no. 3 (March 23, 2019): 478. http://dx.doi.org/10.3390/nano9030478.

Full text
Abstract:
The chemical modification, or functionalization, of the surfaces of nanomaterials is a key step to achieve biosensors with the best sensitivity and selectivity. The surface modification of biosensors usually comprises several modification steps that have to be optimized. Real-time monitoring of all the reactions taking place during such modification steps can be a highly helpful tool for optimization. In this work, we propose nanoporous anodic alumina (NAA) functionalized with the streptavidin-biotin complex as a platform towards label-free biosensors. Using reflective interferometric spectroscopy (RIfS), the streptavidin-biotin complex formation, using biotinylated thrombin as a molecule model, was monitored in real-time. The study compared the performance of different NAA pore sizes in order to achieve the highest response. Furthermore, the optimal streptavidin concentration that enabled the efficient detection of the biotinylated thrombin attachment was estimated. Finally, the ability of the NAA-RIfS system to quantify the concentration of biotinylated thrombin was evaluated. This study provides an optimized characterization method to monitor the chemical reactions that take place during the biotinylated molecules attachment within the NAA pores.
APA, Harvard, Vancouver, ISO, and other styles
28

Paramasivam, Kameshpandian, Yuanzhao Shen, Jiasheng Yuan, Ibtesam Waheed, Chuanbin Mao, and Xin Zhou. "Advances in the Development of Phage-Based Probes for Detection of Bio-Species." Biosensors 12, no. 1 (January 7, 2022): 30. http://dx.doi.org/10.3390/bios12010030.

Full text
Abstract:
Bacteriophages, abbreviated as “phages”, have been developed as emerging nanoprobes for the detection of a wide variety of biological species, such as biomarker molecules and pathogens. Nanosized phages can display a certain length of exogenous peptides of arbitrary sequence or single-chain variable fragments (scFv) of antibodies that specifically bind to the targets of interest, such as animal cells, bacteria, viruses, and protein molecules. Metal nanoparticles generally have unique plasmon resonance effects. Metal nanoparticles such as gold, silver, and magnetism are widely used in the field of visual detection. A phage can be assembled with metal nanoparticles to form an organic–inorganic hybrid probe due to its nanometer-scale size and excellent modifiability. Due to the unique plasmon resonance effect of this composite probe, this technology can be used to visually detect objects of interest under a dark-field microscope. In summary, this review summarizes the recent advances in the development of phage-based probes for ultra-sensitive detection of various bio-species, outlining the advantages and limitations of detection technology of phage-based assays, and highlighting the commonly used editing technologies of phage genomes such as homologous recombination and clustered regularly interspaced palindromic repeats/CRISPR-associated proteins system (CRISPR-Cas). Finally, we discuss the possible scenarios for clinical application of phage-probe-based detection methods.
APA, Harvard, Vancouver, ISO, and other styles
29

Wang, Yujiao, Xiaojun Wang, Wenyu Ma, Runhua Lu, Wenfeng Zhou, and Haixiang Gao. "Recent Developments in Rhodamine-Based Chemosensors: A Review of the Years 2018–2022." Chemosensors 10, no. 10 (October 3, 2022): 399. http://dx.doi.org/10.3390/chemosensors10100399.

Full text
Abstract:
Chemosensors based on traditional fluorescent dyes have always contributed to the development of chemical sensor areas. In this review, the rhodamine-based chemosensors’ improvements and applications from 2018 to 2022 are discussed, mainly focusing on cations (metal ions and H+), anions (CN−, F−, etc.), and small bio-functional molecules’ (thiols, amino acids, etc.) detection. Specifically, this review highlights the detection target, detection limit, detection solution system, detection mechanism, and performance of the rhodamine-based sensors. Although these rhodamine-based sensors are well developed, their repeatability and sensitivity still need significant improvement. This review is expected to bring new clues and bright ideas to researchers for further advances in rhodamine-based chemosensors in the future.
APA, Harvard, Vancouver, ISO, and other styles
30

Singh, Shradhya, Shashi Bala, Balwant Raj, and Balwinder Raj. "Improved Sensitivity of Dielectric Modulated Junctionless Transistor for Nanoscale Biosensor Design." Sensor Letters 18, no. 4 (April 1, 2020): 328–33. http://dx.doi.org/10.1166/sl.2020.4224.

Full text
Abstract:
This work has proposed a device i.e., Dielectric Modulated (DM) Junctionless Transistor which is utilizes as Label-Free (LF) electrical characteristic detection of bio-molecules. The electrical characteristics used for the detection of biomolecules are electric field, surface potential, drain current and threshold voltage (Vth). Due to immobilization of biomolecules in the cavity region, the threshold voltage change in comparison to the absence of biomolecule, which is utilizes as the sensitivity metric. The sensitivity of biomolecule detection can be enhanced by using asymmetric gate operation of the device. In asymmetric mode the degree of sensitivity is almost five times higher than that of the symmetric mode of operation.
APA, Harvard, Vancouver, ISO, and other styles
31

Yoo, Tae-Hee, Hi Gyu Moon, Byung-Yong Wang, Byoung-In Sang, Basavaraj Angadi, Young-Jei Oh, Won Kook Choi, Chong-Yun Kang, and Do Kyung Hwang. "InGaZnO transistor based on porous Ag nanowire-functionalized gate electrode for detection of bio-relevant molecules." Sensors and Actuators B: Chemical 254 (January 2018): 36–43. http://dx.doi.org/10.1016/j.snb.2017.07.022.

Full text
APA, Harvard, Vancouver, ISO, and other styles
32

Li, Xinxin, Haitao Yu, Xiaohua Gan, Xiaoyuan Xia, Pengcheng Xu, Jungang Li, Min Liu, and Yongxiang Li. "Integrated MEMS/NEMS Resonant Cantilevers for Ultrasensitive Biological Detection." Journal of Sensors 2009 (2009): 1–10. http://dx.doi.org/10.1155/2009/637874.

Full text
Abstract:
The paper reviews the recent researches implemented in Chinese Academy of Sciences, with achievements on integrated resonant microcantilever sensors. In the resonant cantilevers, the self-sensing elements and resonance exciting elements are both top-down integrated with silicon micromachining techniques. Quite a lot of effort is focused on optimization of the resonance mode and sensing structure for improvement of sensitivity. On the other hand, to enable the micro-cantilevers specifically sensitive to bio/chemical molecules, sensing materials are developed and modified on the cantilever surface with a self-assembled monolayer (SAM) based bottom-up construction and surface functionalization. To improve the selectivity of the sensors and depress environmental noise, multiple and localized surface modifications are developed. The achieved volume production capability and satisfactory detecting resolution to trace-level biological antigen of alpha-fetoprotein (AFP) give the micro-cantilever sensors a great promise for rapid and high-resoluble detection.
APA, Harvard, Vancouver, ISO, and other styles
33

Sharma, Varsha, and Vijay Laxmi Kalyani. "Design Two Dimensional Nanocavity Photonic Crystal Biosensor Detection in Malaria." International Journal of Emerging Research in Management and Technology 6, no. 6 (June 29, 2018): 16. http://dx.doi.org/10.23956/ijermt.v6i6.239.

Full text
Abstract:
In this paper we design a two dimensional (2-D) photonic crystal based biosensor implemented by linear waveguide and nanocavity detection in malaria. The bio molecules such as a red blood cell, infected red blood cell, trapped inside the nanocavity cause transmission shift at the output terminal. The sensing mechanism of biosensor is change in refractive index of analytes. The layout biosensor is consists a linear waveguide with a nanocavity in square symmetry For the proposed photonic based biosensor, the band gap from 2210nm to 1420 nm and input wavelength of 1550nm are used in this design. The simulation results have analysed by using the finite difference time domain (FDTD) method, bandgap calculation is performed using plane wave expansion method.
APA, Harvard, Vancouver, ISO, and other styles
34

Terracciano, Monica, Ilaria Rea, Nicola Borbone, Rosalba Moretta, Giorgia Oliviero, Gennaro Piccialli, and Luca De Stefano. "Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring." Molecules 24, no. 12 (June 13, 2019): 2216. http://dx.doi.org/10.3390/molecules24122216.

Full text
Abstract:
Aptamers are artificial nucleic acid ligands identified and obtained from combinatorial libraries of synthetic nucleic acids through the in vitro process SELEX (systematic evolution of ligands by exponential enrichment). Aptamers are able to bind an ample range of non-nucleic acid targets with great specificity and affinity. Devices based on aptamers as bio-recognition elements open up a new generation of biosensors called aptasensors. This review focuses on some recent achievements in the design of advanced label-free optical aptasensors using porous silicon (PSi) as a transducer surface for the detection of pathogenic microorganisms and diagnostic molecules with high sensitivity, reliability and low limit of detection (LoD).
APA, Harvard, Vancouver, ISO, and other styles
35

Arnold, S., S. I. Shopova, and S. Holler. "Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs reactive mechanism." Optics Express 18, no. 1 (December 23, 2009): 281. http://dx.doi.org/10.1364/oe.18.000281.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Alshammri, Ghalib H., Walid K. M. Ahmed, and Victor B. Lawrence. "ARFIS: Adaptive-Receiver-Based Fuzzy Inference System for Diffusion- Based Molecular Communications." Current Nanoscience 16, no. 2 (March 26, 2020): 280–89. http://dx.doi.org/10.2174/1573413715666190625114949.

Full text
Abstract:
Background: The architecture and sequential learning rule-based underlying ARFIS (adaptive-receiver-based fuzzy inference system) are proposed to estimate and predict the adaptive threshold-based detection scheme for diffusion-based molecular communication (DMC). Method: The proposed system forwards an estimate of the received bits based on the current molecular cumulative concentration, which is derived using sequential training-based principle with weight and bias and an input-output mapping based on both human knowledge in the form of fuzzy IFTHEN rules. The ARFIS architecture is employed to model nonlinear molecular communication to predict the received bits over time series. Result: This procedure is suitable for binary On-OFF-Keying (Book signaling), where the receiver bio-nanomachine (Rx Bio-NM) adapts the 1/0-bit detection threshold based on all previous received molecular cumulative concentrations to alleviate the inter-symbol interference (ISI) problem and reception noise. Conclusion: Theoretical and simulation results show the improvement in diffusion-based molecular throughput and the optimal number of molecules in transmission. Furthermore, the performance evaluation in various noisy channel sources shows promising improvement in the un-coded bit error rate (BER) compared with other threshold-based detection schemes in the literature.
APA, Harvard, Vancouver, ISO, and other styles
37

BRANEN, JOSH R., MARTHA J. HASS, ERIN R. DOUTHIT, WUSI C. MAKI, and A. LARRY BRANEN. "Detection of Escherichia coli O157, Salmonella enterica Serovar Typhimurium, and Staphylococcal Enterotoxin B in a Single Sample Using Enzymatic Bio-Nanotransduction." Journal of Food Protection 70, no. 4 (April 1, 2007): 841–50. http://dx.doi.org/10.4315/0362-028x-70.4.841.

Full text
Abstract:
Enzymatic bio-nanotransduction is a biological detection scheme based on the production of nucleic acid nano-signals (RNA) in response to specific biological recognition events. In this study, we applied an enzymatic bio-nanotransduction system to the detection of important food-related pathogens and a toxin. Escherichia coli O157:H7, Salmonella enterica serovar Typhimurium, and staphylococcal enterotoxin B (SEB) were chosen because of the implications of these targets to food safety. Primary antibodies to each of the targets were used to functionalize magnetic beads and produce biological recognition elements (antibodies) conjugated to nano-signal–producing DNA templates. Immunomagnetic capture that was followed by in vitro transcription of DNA templates bound to target molecules produced RNA nano-signals specific for every target in the sample. Discrimination of RNA nano-signals with a standard enzyme-linked oligonucleotide fluorescence assay provided a correlation between nano-signal profiles and target concentrations. The estimated limit of detection was 2.4 × 103 CFU/ml for E. coli O157:H7, 1.9 × 104 CFU/ml for S. enterica serovar Typhimurium, and 0.11 ng/ml for SEB with multianalyte detection in buffer. Low levels of one target were also detected in the presence of interference from high levels of the other targets. Finally, targets were detected in milk, and detection was improved for E. coli O157 by heat treatment of the milk.
APA, Harvard, Vancouver, ISO, and other styles
38

BYKHOVSKI, ALEXEI, TATIANA GLOBUS, TATYANA KHROMOVA, BORIS GELMONT, and DWIGHT WOOLARD. "AN ANALYSIS OF THE THZ FREQUENCY SIGNATURES IN THE CELLULAR COMPONENTS OF BIOLOGICAL AGENTS." International Journal of High Speed Electronics and Systems 17, no. 02 (June 2007): 225–37. http://dx.doi.org/10.1142/s012915640700445x.

Full text
Abstract:
The development of an effective biological (bio) agent detection capability based upon terahertz (THz) frequency absorption spectra will require insight into how the constituent cellular components contribute to the overall THz signature. In this work, the specific contribution of ribonucleic acid (RNA) to THz spectra is analyzed in detail. Previously, it has only been possible to simulate partial fragments of the RNA (or DNA) structures due to the excessive computational demands. For the first time, the molecular structure of the entire transfer RNA (tRNA) molecule of E. coli was simulated and the associated THz signature was derived theoretically. The tRNA that binds amino acid tyrosine (tRNAtyr) was studied. Here, the molecular structure was optimized using the potential energy minimization and molecular dynamical (MD) simulations. Solvation effects (water molecules) were also included explicitly in the MD simulations. To verify that realistic molecular signatures were simulated, a parallel experimental study of tRNAs of E. coli was also conducted. Two very similar molecules, valine and tyrosine tRNA were investigated experimentally. Samples were prepared in the form of water solutions with the concentrations in the range 0.01-1 mg/ml. A strong correlation of the measured THz signatures associated with valine tRNA and tyrosine tRNA was observed. These findings are consistent with the structural similarity of the two tRNAs. The calculated THz signature of the tyrosine tRNA of E. coli reproduces many features of our measured spectra, and, therefore, provides valuable new insights into bio-agent detection.
APA, Harvard, Vancouver, ISO, and other styles
39

Wang, Hao, Lu Chen, Min Li, Yongxin She, Chao Zhu, and Mengmeng Yan. "An Alkyne-Mediated SERS Aptasensor for Anti-Interference Ochratoxin A Detection in Real Samples." Foods 11, no. 21 (October 28, 2022): 3407. http://dx.doi.org/10.3390/foods11213407.

Full text
Abstract:
Avoiding interference and realizing the precise detection of mycotoxins in complex food samples is still an urgent problem for surface-enhanced Raman spectroscopy (SERS) analysis technology. Herein, a highly sensitive and specific aptasensor was developed for the anti-interference detection of Ochratoxin A (OTA). In this aptasensor, 4-[(Trimethylsilyl) ethynyl] aniline was employed as an anti-interference Raman reporter to prove a sharp Raman peak (1998 cm−1) in silent region, which could avoid the interference of food bio-molecules in 600–1800 cm−1. 4-TEAE and OTA-aptamer were assembled on Au NPs to serve as anti-interference SERS probes. Meanwhile, Fe3O4 NPs, linked with complementary aptamer (cApts), were applied as capture probes. The specific binding of OTA to aptamer hindered the complementary binding of aptamer and cApt, which inhibited the binding of SERS probes and capture probes. Hence, the Raman responses at 1998 cm−1 were negatively correlated with the OTA level. Under the optimum condition, the aptasensor presented a linear response for OTA detection in the range of 0.1–40 nM, with low detection limits of 30 pM. In addition, the aptasensor was successfully applied to quantify OTA in soybean, grape and milk samples. Accordingly, this anti-interference aptasensor could perform specific, sensitive and precise detection of OTA in real samples, and proved a reliable reference strategy for other small-molecules detection in food samples.
APA, Harvard, Vancouver, ISO, and other styles
40

Chinnadayyala, Somasekhar R., and Sungbo Cho. "Electrochemical Immunosensor for the Early Detection of Rheumatoid Arthritis Biomarker: Anti-Cyclic Citrullinated Peptide Antibody in Human Serum Based on Avidin-Biotin System." Sensors 21, no. 1 (December 28, 2020): 124. http://dx.doi.org/10.3390/s21010124.

Full text
Abstract:
Rheumatoid arthritis (RA) is a chronic autoimmune disease that produces a progressive inflammatory response that leads to severe pain, swelling, and stiffness in the joints of hands and feet, followed by irreversible damage of the joints. The authors developed a miniaturized, label-free electrochemical impedimetric immunosensor for the sensitive and direct detection of arthritis Anti-CCP-ab biomarker. An interdigitated-chain-shaped microelectrode array (ICE) was fabricated by taking the advantage of microelectromechanical systems. The fabricated ICE was modified with a self-assembled monolayer (SAM) of Mercaptohexanoic acid (MHA) for immobilization of the synthetic peptide bio-receptor (B-CCP). The B-CCP was attached onto the surface of SAM modified ICE through a strong avidin-biotin bio-recognition system. The modified ICE surface with the SAM and bio-molecules (Avidin, B-CCP, Anti-CCP-ab and BSA) was morphologically and electrochemically characterized. The change in the sensor signal upon analyte binding on the electrode surface was probed through the electrochemical impedance spectroscopy (EIS) property of charge-transfer resistance (Rct) of the modified electrodes. EIS measurements were target specific and the sensor response was linearly increased with step wise increase in target analyte (Anti-CCP-ab) concentrations. The developed sensor showed a linear range for the addition of Anti-CCP-ab between 1 IU mL−1 → 800 IU mL−1 in phosphate buffered saline (PBS) and Human serum (HS), respectively. The sensor showed a limit of detection of 0.60 IU mL−1 and 0.82 IU mL−1 in the PBS and HS, respectively. The develop bio-electrode showed a good reproducibility (relative standard deviation (RSD), 1.52%), selectivity and stability (1.5% lost at the end of 20th day) with an acceptable recovery rate (98.0% → 101.18%) and % RSD’s for the detection of Anti-CCP-ab in spiked HS samples.
APA, Harvard, Vancouver, ISO, and other styles
41

Agarwal, R., R. Mukhiya, R. Sharma, M. K. Sharma, and A. K. Goel. "Finite Element Method-based Design and Simulations of Micro-cantilever Platform for Chemical and Bio-sensing Applications." Defence Science Journal 66, no. 5 (September 30, 2016): 485. http://dx.doi.org/10.14429/dsj.66.10702.

Full text
Abstract:
Micro-electro-mechanical systems (MEMS)-based cantilever platform have capability for the detection of chemical and biological agents. This paper reports about the finite element method (FEM) based design and simulations of MEMS-based piezoresistor cantilever platform to be used for detection of chemical and biological toxic agents. Bulk micromachining technique is adopted for the realisation of the device structure. MEMS piezoresistive biosensing platforms are having potential for a field-based label-free detection of various types of bio-molecules. Using the MEMMECH module of CoventorWare® simulations are performed on the designed model of the device and it is observed that principal stress is maximum along the length (among other dimensions of the micro-cantilever) and remains almost constant for 90 per cent of the length of the micro-cantilever. The dimensions of piezoresistor are optimised and the output voltage vs. stress analysis for various lengths of the piezoresistor is performed using the MEMPZR module of the CoventorWare®.
APA, Harvard, Vancouver, ISO, and other styles
42

Johnson, Leah M., Heather J. Avens, Ryan R. Hansen, Holly L. Sewell, and Christopher N. Bowman. "Characterization of the Assaying Methods in Polymerization-Based Amplification of Surface Biomarkers." Australian Journal of Chemistry 62, no. 8 (2009): 877. http://dx.doi.org/10.1071/ch09095.

Full text
Abstract:
Polymerization-based amplification (PBA), which combines bio-recognition events with polymerization reactions on surfaces, provides visual, sensitive, and cost-effective detection of biological interactions, particularly at extremely low levels of the targeted biological moiety. This study characterizes assay parameters that enhance the utility of PBA to detect nucleic acid and protein biomarkers. Here, we successfully employ PBA on surfaces that contain uniform, high density, immobilized capture molecules, including three-dimensional nitrocellulose-coated substrates. Optimized assay and polymerization conditions are used to characterize the dynamic polymer film heights on glass substrates that result from solutions of KRAS proto-oncogene biomarker targets at concentrations between 5 nM and 500 pM. Differing aqueous monomer formulations are utilized to produce 20 nm films at the 500 pM DNA detection limit.
APA, Harvard, Vancouver, ISO, and other styles
43

Voronine, Dmitri V., Zhenrong Zhang, Alexei V. Sokolov, and Marlan O. Scully. "Surface-enhanced FAST CARS: en route to quantum nano-biophotonics." Nanophotonics 7, no. 3 (February 23, 2018): 523–48. http://dx.doi.org/10.1515/nanoph-2017-0066.

Full text
Abstract:
AbstractQuantum nano-biophotonics as the science of nanoscale light-matter interactions in biological systems requires developing new spectroscopic tools for addressing the challenges of detecting and disentangling weak congested optical signals. Nanoscale bio-imaging addresses the challenge of the detection of weak resonant signals from a few target biomolecules in the presence of the nonresonant background from many undesired molecules. In addition, the imaging must be performed rapidly to capture the dynamics of biological processes in living cells and tissues. Label-free non-invasive spectroscopic techniques are required to minimize the external perturbation effects on biological systems. Various approaches were developed to satisfy these requirements by increasing the selectivity and sensitivity of biomolecular detection. Coherent anti-Stokes Raman scattering (CARS) and surface-enhanced Raman scattering (SERS) spectroscopies provide many orders of magnitude enhancement of chemically specific Raman signals. Femtosecond adaptive spectroscopic techniques for CARS (FAST CARS) were developed to suppress the nonresonant background and optimize the efficiency of the coherent optical signals. This perspective focuses on the application of these techniques to nanoscale bio-imaging, discussing their advantages and limitations as well as the promising opportunities and challenges of the combined coherence and surface enhancements in surface-enhanced coherent anti-Stokes Raman scattering (SECARS) and tip-enhanced coherent anti-Stokes Raman scattering (TECARS) and the corresponding surface-enhanced FAST CARS techniques. Laser pulse shaping of near-field excitations plays an important role in achieving these goals and increasing the signal enhancement.
APA, Harvard, Vancouver, ISO, and other styles
44

Doc Richardson, C., Nancy W. Hinman, and Jill R. Scott. "Effect of thenardite on the direct detection of aromatic amino acids: implications for the search for life in the solar system." International Journal of Astrobiology 8, no. 4 (August 28, 2009): 291–300. http://dx.doi.org/10.1017/s1473550409990231.

Full text
Abstract:
AbstractWith the discovery of Na-sulphate minerals on Mars and Europa, recent studies using these minerals have focused on their ability to assist in the detection of bio/organic signatures. This study further investigates the ability of thenardite (Na2SO4) to effectively facilitate the ionization and identification of aromatic amino acids (phenylalanine, tyrosine and tryptophan) using a technique called geomatrix-assisted laser desorption/ionization in conjunction with a Fourier transform ion cyclotron resonance mass spectrometry. This technique is based on the ability of a mineral host to facilitate desorption and ionization of bio/organic molecules for detection. Spectra obtained from each aromatic amino acid alone and in combination with thenardite show differences in ionization mechanism and fragmentation patterns. These differences are due to chemical and structural differences between the aromatic side chains of their respective amino acid. Tyrosine and tryptophan when combined with thenardite were observed to undergo cation-attachment ([M+Na]+), due to the high alkali ion affinity of their aromatic side chains. In addition, substitution of the carboxyl group hydrogen by sodium led to formation of [M-H+Na]Na+ peaks. In contrast, phenylalanine mixed with thenardite showed no evidence of Na+ attachment. Understanding how co-deposition of amino acids with thenardite can affect the observed mass spectra is important for future exploration missions that are likely to use laser desorption mass spectrometry to search for bio/organic compounds in extraterrestrial environments.
APA, Harvard, Vancouver, ISO, and other styles
45

Courtier, Audrey, Benoit Roig, Stephane Cariou, Axelle Cadiere, and Sandrine Bayle. "Evaluation of Coriolis Micro Air Sampling to Detect Volatile and Semi-Volatile Organic Compounds." Molecules 27, no. 19 (September 30, 2022): 6462. http://dx.doi.org/10.3390/molecules27196462.

Full text
Abstract:
There are several analytical procedures available for the monitoring of volatile organic compounds (VOCs) in the air, which differ mainly on sampling procedures. The Coriolis micro air sampler is a tool normally designed for biological air sampling. In this paper, the Coriolis micro bio collector is used to evaluate its ability to sample organic contaminants sampling and detecting them when combined GC-MS. We also compare the use of the Coriolis micro with a standardized sampling method, which is the use of a lung box with a Nalophan® bag. The results show that the Coriolis micro sampling method is suitable for the sampling of organic contaminants. Indeed, the Coriolis micro allows to sample and detect mainly semi-volatile molecules, while the lung box/Nalophan® bags allow to sample more volatile molecules (highly volatile and volatile). These results were confirmed in the controlled air lab with a slight difference with the field. The simultaneous use of the both techniques allow to sample and detect a larger number of molecules with specific physicochemical properties to each sampling technique. In conclusion, the Coriolis micro can sample and detect volatile organic compounds present in air. We have shown that the development of alternative sampling methods and the use of non-target analysis are essential for a more comprehensive risk assessment. Moreover, the use of the Coriolis micro allows the detection of emergent molecules around the Thau lagoon.
APA, Harvard, Vancouver, ISO, and other styles
46

Zhu, Xin-Yi, Bo-Ran Wang, Yi Gu, Hao Zhu, Lin Chen, and Qing-Qing Sun. "Novel Nanofluidic Cells Based on Nanowires and Nanotubes for Advanced Chemical and Bio-Sensing Applications." Nanomaterials 11, no. 1 (January 3, 2021): 90. http://dx.doi.org/10.3390/nano11010090.

Full text
Abstract:
Since the first introduction of one-dimensional nanochannels for single-molecule detection, there has been increasing interest in modern nanofluidic systems, such as chemical and biological sensing applications. Recently developed nanowires (NWs) and nanotubes (NTs) have received tremendous attention due to their unique geometrical, physical and chemical properties, which are very attractive in this field. Here, we review the recent research activities in the field of novel nanofluidic cells based on NWs and NTs. First, we give a brief introduction of this field. Then the common synthesis methods of NWs and NTs are summarized. After that, we discuss the working principle and sensing mechanism of nanofluidic devices, which is fundamental to the interaction between these nanostructures and small molecules. Finally, we present the NW- and NT-based devices for chemical and bio-sensing applications, such as gas sensing, pathogen detection, DNA sequencing, and so forth.
APA, Harvard, Vancouver, ISO, and other styles
47

Wandel, Amri. "Bio-habitability and life on planets of M-G-type stars." Proceedings of the International Astronomical Union 14, S345 (August 2018): 189–93. http://dx.doi.org/10.1017/s1743921319001984.

Full text
Abstract:
AbstractThe recent detection of Earth-sized planets in the habitable zone of Proxima Centauri, Trappist-1, and many other nearby M-type stars (which consist some 75% of the stars) has led to speculations, whether liquid water and life actually exist on these planets. Defining the bio-habitable zone, where liquid water and complex organic molecules can survive on at least part of the planetary surface, we suggest that planets orbiting M-type stars may have life-supporting conditions for a wide range of atmospheric properties (Wandel2018). We extend this analysis to synchronously orbiting planets of K- and G-type stars and discuss the implications for the evolution and sustaining of life on planets of M- to G-type stars, in analogy to Earth.
APA, Harvard, Vancouver, ISO, and other styles
48

Kathavate, Pravin Narayan, and J. Amudhavel. "Lipoprotein detection: Hybrid deep classification model with improved feature set." Multiagent and Grid Systems 18, no. 3-4 (February 3, 2023): 345–63. http://dx.doi.org/10.3233/mgs-220329.

Full text
Abstract:
Patients with chronic liver diseases typically experience lipid profile problems, and mortality from cirrhosis complicated by portal vein thrombosis (PVT) is very significant. A lipoprotein (Lp) is a bio-chemical assemblage with the main job of moving fat molecules in water that are hydrophobic. Lipoproteins are present in all eubacterial walls. Lipoproteins are of tremendous interest in the study of spirochaetes’ pathogenic mechanisms. Since spirochaete lipobox sequences are more malleable than other bacteria, it’s proven difficult to apply current prediction methods to new sequence data. The major goal is to present a Lipoprotein detection model in which correlation features, enhanced log energy entropy, raw features, and semantic similarity features are extracted. These extracted characteristics are put through a hybrid model that combines a Gated Recurrent Unit (GRU) and a Long Short-Term Memory (LSTM). Then, the outputs of GRU and LSTM are averaged to obtain the output. Here, GRU weights are optimized via the Selfish combined Henry Gas Solubility Optimization with cubic map initialization (SHGSO) model.
APA, Harvard, Vancouver, ISO, and other styles
49

Bano, Edwige, Louis Fradetal, Valérie Stambouli, and Giovanni Attolini. "DNA Detection Using SiC Nanowire Based Transistor." Materials Science Forum 858 (May 2016): 1006–9. http://dx.doi.org/10.4028/www.scientific.net/msf.858.1006.

Full text
Abstract:
The fast and direct detection of small quantities of biomolecules improves early medical diagnosis of certain serious diseases as cancers and can be used to detect in situ the presence of pathogenic viruses or GMOs for food industry, protection environmental and bio-defense. Numerous research projects are conducted on nanoelectronic devices that can perform such detection with high sensitivity using nanostructures. Currently, these devices are made from Silicon nanowires [1]. For these applications, Silicon Carbide (SiC) material can advantageously replace Silicon as this semiconductor is now known to be biocompatible and to show a high chemical inertness [2]. Here, we present the electrical detection of DNA using a SiC Nanowire Field Effect Transistor (NWFET). The NWFETs are fabricated and then functionalized with DNA molecules. Between each step of the functionalization process, I-V characteristic measurements are performed. Comparative and simultaneous measurements are carried out on two SiC NWFETs: one is the sensor and the second one is used as a reference. Some interesting properties of the sensor are studied for the first time which opens the way to future developments of SiC nanowire based sensors.
APA, Harvard, Vancouver, ISO, and other styles
50

Roy, Dhruvajyoti, Andreas Pascher, Mazen A. Juratli, and Judith C. Sporn. "The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer." International Journal of Molecular Sciences 22, no. 11 (May 25, 2021): 5601. http://dx.doi.org/10.3390/ijms22115601.

Full text
Abstract:
The early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuously monitor disease progression and treatment efficacy. Various methods have been implemented to isolate and purify bio-analytes in liquid biopsy specimens. Aptamers are short oligonucleotides consisting of either DNA or RNA that are capable of binding to target molecules with high specificity. Due to their unique properties, they are considered promising recognition ligands for the early detection of cancer by liquid biopsy. A variety of circulating targets have been isolated with high affinity and specificity by facile modification and affinity regulation of the aptamers. In this review, we discuss recent progress in aptamer-mediated liquid biopsy for cancer detection, its associated challenges, and its future potential for clinical applications.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography