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Kim, Jin-Dong, Tomoko Ohta, Sampo Pyysalo, Yoshinobu Kano, and Jun’ichi Tsujii. "EXTRACTING BIO-MOLECULAR EVENTS FROM LITERATURE-THE BIONLP’09 SHARED TASK." Computational Intelligence 27, no. 4 (November 2011): 513–40. http://dx.doi.org/10.1111/j.1467-8640.2011.00398.x.
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TANAKA, Yoshihiro, Kazuki DOUMOTO, Akihito SANO, and Hideo FUJIMOTO. "BIO-09 EXPANSION OF BALLOON ON SOFT OBJECT AND ITS APPLICATION TO TACTILE SENSOR(Bio-medical Equipments III,Technical Program of Oral Presentations)." Proceedings of JSME-IIP/ASME-ISPS Joint Conference on Micromechatronics for Information and Precision Equipment : IIP/ISPS joint MIPE 2009 (2009): 313–14. http://dx.doi.org/10.1299/jsmemipe.2009.313.
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Werner, Karel. "Lebensbilder deutscher Buddhisten. Ein bio-bibliographisches Handbuch. Band I: Die Gründer. Band II: Die Nachfolger. Edited by Hellmuth Hecker." Buddhist Studies Review 15, no. 1 (June 16, 1998): 129–31. http://dx.doi.org/10.1558/bsrv.v15i1.14832.
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Lebensbilder deutscher Buddhisten. Ein bio-bibliographisches Handbuch. Band I: Die Gründer. Band II: Die Nachfolger. Edited by Hellmuth Hecker. Universität Konstanz, Forschungsprojekt 'Buddhistischer Modernismus', Forschungsberichte 13-14, Konstanz 1996-7. 214 and 405 pp. No price given. ISBN 3-930959-09-7 and -10-0.
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Pathak, R. "Age at Menopause and Associated Bio-Social Factors of Health in Punjabi Women~!2009-09-14~!2009-10-28~!2010-09-02~!" Open Anthropology Journal 3, no. 3 (September 3, 2010): 172–80. http://dx.doi.org/10.2174/1874912701003030172.
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Zhang, Y., J. Nasehi Tehrani, and J. Wang. "MO-AB-BRA-09: Development and Evaluation of a Biomechanical Modeling-Assisted CBCT Reconstruction Technique (Bio-Recon)." Medical Physics 43, no. 6Part28 (June 2016): 3692. http://dx.doi.org/10.1118/1.4957161.
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Ghimire, Tara Bahadur, and Om Prakash Singh Bana. "Soil Physico-Bio-Chemical Properties under Poplar + Indian Mustard Inter Cropping System." Journal of Nepal Agricultural Research Council 1 (September 20, 2016): 14–20. http://dx.doi.org/10.3126/jnarc.v1i0.15719.
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A field experiment was conducted during the winter seasons of 2008-10 at Agroforestry Research Centre, Pantnagar, India with aim to examine the effect of different levels of recommended Nitrogen (N): Phosphorus (P): Potassium (K) (NPK) on soil physico-bio-chemical properties under varying poplar tree densities with mustard introcropping. Lower soil bulk density was recorded under 1000 trees/ha density compared to sole crop in both the year. Soil bulk density (BD) decreased underneath trees. However, soil pH, available N and K were not influenced by tree density in both the years. Electrical conductivity (EC) and soil organic carbon (SOC) increased underneath trees of either tree density compared to sole crop in both the years. Significantly (P<0.05) higher available P was recorded under 1000 trees/ha density compared to 250 and 500 trees/ha densities including sole crop in 2008-09. Similarly, soil microbial biomass carbon (SMBC) increased with increasing the tree density and significantly (P<0.01) higher value was recorded under 1000 trees/ha density compared to sole crop and sparse density both the years except 2009-10, where 500 and 1000 trees/ha densities remain statistically at par. On the other hand, dehydrogenase activity (DA) was maximum under 500 trees/ha density compared to sole crop and 1000 trees/ha density in both the years. Among the fertility levels, the maximum SOC and available N were recorded with 75% compared to 50, 100 and 125% of recommended NPK in 2008-09, except available N with 100% of recommended NPK. But, available P was more with 100% of recommended NPK in 2008-09. Similarly, maximum SMBC were recorded with 75 % compared to higher doses of recommended NPK in both the years. Similarly, BD, EC, SOC, available N, P and K were recorded maximum and soil pH minimum in 0-15 cm soil layers compared deeper layers.Journal of Nepal Agricultural Research Council Vol.1 2015 pp.14-20
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Jairath, V., A. Armuzzi, R. K. Pai, D. Sun, Y. Li, M. Bassel, N. R. Brett, and D. Bojic. "P772 Association of histological remission with long-term clinical outcomes in patients with ulcerative colitis: a multi-national retrospective study with centralized histological assessment." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i900—i903. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0902.
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Abstract Background Histological remission (HR) is an achievable therapeutic target in ulcerative colitis (UC), however there is limited data on the association of HR with long-term clinical outcomes. We evaluated the association between HR and a composite outcome of colectomy, UC-related hospitalization, or intravenous (IV) corticosteroid use in patients with UC. Methods This was a multi-national retrospective study of adult patients with UC treated with a biologic or small molecule drug between 09/01/2005 and 06/30/2019 in Canada, Italy, Netherlands and United States. The study included biologic-naïve (bio-naïve) and biologic-experienced (bio-exp) patients. Biopsies taken during routine practice were procured and re-assessed for histological activity by blinded gastrointestinal pathologists in a central laboratory. HR was defined as the absence of neutrophilic inflammation (Nancy Histological Index ≤1 or Robarts Histological Index ≤3 plus Geboes subgrades 2B.0/3.0) at the most recent endoscopic evaluation within 3 to 9 months after treatment initiation. Cumulative risk of time-to-event outcome over 12 months from treatment initiation was evaluated using Kaplan-Meier (KM) methods and Cox proportional hazard analysis. Statistical significance was set as p-value <0.05. Results We included 227 patients with UC (bio-naïve and bio-exp) (Table 1); of whom, 132 (58%) were bio-naïve (Table 2). Of the bio-naïve patients, 62 (47%) achieved HR and 70 (53%) had histologic activity; 9 (6.8%) underwent colectomy, 16 (12.1%) had UC-related hospitalizations, and 8 (6.1%) received IV corticosteroid. Unadjusted time-to-event for the composite outcome was significantly greater in bio-naïve patients who achieved HR compared to those who did not (p=0.0023; Figure 1A). In multivariable analysis, the association of HR on the composite outcome in bio-naïve patients was not statistically significant (adjusted hazard ratio [aHR], 0.26; 95% CI, 0.02-4.42). In the overall patients (bio-naïve and bio-exp), unadjusted (p<0.001; Figure 1B) and multivariable (aHR, 0.32; 95% CI, 0.06-1.75) associations of HR and the composite outcome were similar to the bio-naïve patients. Conclusion We used central reading to evaluate the association of HR and clinical outcomes in patients with UC. While unadjusted KM curves showed that HR was associated with decreased risk of the composite outcome, the association was no longer significant after adjustment for covariates. The target sample size for this study was not achieved and the number of events was small, resulting in reduced statistical power. Future studies are warranted to explore the association further.
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MIWA, MAKOTO, RUNE SÆTRE, JIN-DONG KIM, and JUN'ICHI TSUJII. "EVENT EXTRACTION WITH COMPLEX EVENT CLASSIFICATION USING RICH FEATURES." Journal of Bioinformatics and Computational Biology 08, no. 01 (February 2010): 131–46. http://dx.doi.org/10.1142/s0219720010004586.
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Biomedical Natural Language Processing (BioNLP) attempts to capture biomedical phenomena from texts by extracting relations between biomedical entities (i.e. proteins and genes). Traditionally, only binary relations have been extracted from large numbers of published papers. Recently, more complex relations (biomolecular events) have also been extracted. Such events may include several entities or other relations. To evaluate the performance of the text mining systems, several shared task challenges have been arranged for the BioNLP community. With a common and consistent task setting, the BioNLP'09 shared task evaluated complex biomolecular events such as binding and regulation.Finding these events automatically is important in order to improve biomedical event extraction systems. In the present paper, we propose an automatic event extraction system, which contains a model for complex events, by solving a classification problem with rich features. The main contributions of the present paper are: (1) the proposal of an effective bio-event detection method using machine learning, (2) provision of a high-performance event extraction system, and (3) the execution of a quantitative error analysis. The proposed complex (binding and regulation) event detector outperforms the best system from the BioNLP'09 shared task challenge.
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Oldham, M., A. Thomas, and M. Dewhirst. "MO-D-141-09: An Investigation of the Feasibility of Volumetric Imaging of Fluorescent Bio-Markers Using Optical-ECT." Medical Physics 40, no. 6Part24 (June 2013): 401. http://dx.doi.org/10.1118/1.4815256.
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Zhdanava, Maryia, Zhijie Ding, Ameur Manceur, Sumesh Kachroo, Christopher Holiday, Ruizhi Zhao, and Dominic Pilon. "PERSISTENCE WHILE ON LABELED MAINTENANCE DOSE AMONG BIO-EXPERIENCED PATIENTS WITH CROHN'S DISEASE INITIATED ON USTEKINUMAB COMPARED TO ADALIMUMAB." Inflammatory Bowel Diseases 29, Supplement_1 (January 26, 2023): S36. http://dx.doi.org/10.1093/ibd/izac247.066.
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Abstract BACKGROUND In Crohn’s disease (CD), dose escalation on biologic therapy may be required to maintain effectiveness, while adverse events or non-response, among other factors, may lead to lack of persistence. Understanding persistence while on labeled maintenance dose is particularly important in bio-experienced patients with CD, as they may have reduced response to subsequent lines of therapy. This analysis compared persistence while on labeled maintenance dose among bio-experienced patients on ustekinumab versus adalimumab in the United States (US). METHODS Adults with CD initiated on ustekinumab or adalimumab (index date) between 09/23/2016 (ustekinumab approval for CD in the US) and 08/01/2019 were selected from IBM® MarketScan® Commercial Database. Patients were bio-experienced (≥1 claim for another CD-indicated biologic in the 12 months baseline period pre-index date). Patients with other auto-immune diseases at baseline were excluded. Cohorts were balanced on baseline characteristics using inverse probability of treatment weights. Persistence to the index agent while on labeled maintenance dose was defined as (1) no gaps between days of therapy supply >120 days for ustekinumab (2 x 8-week on-label maintenance dose interval) or >60 days for adalimumab (2 x days of supply mode) and (2) no dose change relative to the US label maintenance dose. It was assessed from index date until the earliest of discontinuation (event), dose change during maintenance phase (censoring), or last day of supply (censoring). Weighted Kaplan-Meier and Cox proportional hazards models adjusted for baseline classes of biologics were used to assess the outcome at 12 months post-index. RESULTS 903 bio-experienced patients with CD were included in the ustekinumab cohort (mean age 40.9 years old; 57.1% female) and 525 in the adalimumab cohort (mean age 41.3; 56.3% female). During the baseline period, 71.1% and 72.6% used corticosteroids, 41.2% and 40.8% used immunomodulators, and 11.1% and 12.6% had a prior CD-related surgery, in the ustekinumab and adalimumab cohorts, respectively. At 12 months post-index, the probability of persisting on the index biologic while on labeled maintenance dose was higher in the ustekinumab cohort versus adalimumab cohort (78.8% vs. 67.8%; Fig. 1). Patients in the ustekinumab versus adalimumab cohort had a 71% higher rate of persistence while on labeled maintenance dose (hazard ratio [HR] 1.71; 95% confidence interval: 1.31-2.23; P-value: <0.001*). CONCLUSIONS Bio-experienced patients with CD initiated on ustekinumab were significantly more persistent while on labeled maintenance dose compared to patients initiated on adalimumab. These results confirm results on persistence to biologics in bio-experienced patients with CD from a prior study.
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Uddin, Md Jasim, Irin Sultana, Ayesha Amin Nipa, M. Mohi Uddin Chowdhury, and Dennis Douroumis. "Future drug delivery technologies: benchtop to industry." IIUC Studies 14, no. 1 (July 29, 2018): 9–20. http://dx.doi.org/10.3329/iiucs.v14i1.37651.
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Transmucosal buccal drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for paediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucloxacillin sodium, across the mucosal route. The buccal films are comprised of a bio-adhesive polymer, plasticizer and drug. Optimised films were characterised by measurement of weight, length and width, hardness, thickness, surface pH, moisture content and uptake, swelling study, folding resilience, hydration and entrapment efficiency. Drug release studies were performed for different polymer-plasticizer-drug ratios. Concentration of polymer and plasticizer were influenced on the development, evaluation and release rate of flucloxacillin sodium from the buccal films. In conclusion, these studies reveal that buccal delivery of flucloxacillin sodium can be an alternative route in comparison to conventional route for patient compliance.IIUC Studies Vol.14(1) June 2017: 09-20
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Franceschi, Elton, Alana de Cezaro, Sandra R. S. Ferreira, Marcos H. Kunita, Edvani C. Muniz, Adley F. Rubira, and J. Vladimir Oliveira. "Co-Precipitation of Beta-Carotene and Bio-Polymer Using Supercritical Carbon Dioxide as Antisolvent~!2009-09-01~!2009-12-08~!2010-03-25~!" Open Chemical Engineering Journal 4, no. 2 (April 7, 2010): 11–20. http://dx.doi.org/10.2174/1874123101004020011.
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Zhdanava, Maryia, Zhijie Ding, Ameur Manceur, Ruizhi Zhao, Christopher Holiday, Sumesh Kachroo, Erik Muser, and Dominic Pilon. "SUPERIOR PERSISTENCE WHILE ON LABELED MAINTENANCE DOSE AMONG BIO-NAÏVE PATIENTS WITH CROHN'S DISEASE INITIATED ON USTEKINUMAB COMPARED TO ADALIMUMAB." Inflammatory Bowel Diseases 29, Supplement_1 (January 26, 2023): S37. http://dx.doi.org/10.1093/ibd/izac247.068.
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Abstract BACKGROUND Treatment of Crohn’s disease (CD) may require biologics. Dose escalation may be necessary to maintain efficacy, while adverse events or non-response may lead to treatment discontinuation. This analysis aimed to generate real-world evidence of persistence to ustekinumab versus adalimumab while on labeled maintenance dose (United States [US] prescribing information) among bio-naïve patients with CD in the US. METHODS Adults with CD initiated on ustekinumab or adalimumab from 09/23/2016 (approval of ustekinumab for CD in the US) to 08/01/2019 were selected from a de-identified health insurance claims database (IQVIA PharMetrics® Plus). Patients who used other biologics indicated for CD or had diagnoses for other autoimmune disorders in the 12 months before the initiation of the index agent (baseline) were excluded. Cohorts were balanced on baseline characteristics using inverse probability of treatment weights. Persistence to the index agent while on labeled maintenance dose was defined as (1) absence of gaps between days of therapy supply >120 days for ustekinumab (twice the 8-week on-label maintenance dosing interval) or >60 days for adalimumab (twice the mode of days of supply in claims) and (2) absence of any dose change during the maintenance phase relative to the dose per US label. It was assessed from the index date until the earliest of discontinuation (event), dose change during the maintenance phase (censoring), or the last day of index agent supply before the end of follow-up (censoring). Weighted Kaplan-Meier and Cox proportional hazards models were used to assess the outcome at 12 months post-index. RESULTS 948 bio-naïve patients with CD were included in the ustekinumab cohort (mean age 42.5 years old; 58.1% female) and 4,143 in the adalimumab cohort (mean age 42.3 years old; 56.7% female). During the baseline period, 8.4% and 9.2% previously had CD-related surgery, 66.6% and 67.7% used corticosteroids, and 25.9% and 26.3% used immunomodulators in the ustekinumab and adalimumab cohorts, respectively. At 12 months post-index, a higher proportion of patients in the ustekinumab cohort versus adalimumab cohort were persistent to the index biologic while on labeled maintenance dose (74.1% vs 65.4%; Fig. 1). Patients in the ustekinumab versus adalimumab cohort had a 47% higher rate of persistence while on labeled maintenance dose (hazard ratio [HR] 1.47; 95% confidence interval [CI]: 1.25-1.73; P-value: <0.001*). CONCLUSIONS Bio-naïve patients with CD initiated on ustekinumab were significantly more persistent while on labeled maintenance dose compared to patients initiated on adalimumab. These results are consistent with previous work, which demonstrated significantly higher persistence to the index agent and a trend of lower dose escalation rates among bio-naïve patients with CD initiating ustekinumab versus adalimumab.
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Katidi, Alexandra, Anthi Pavlopoulou, Antonis Vlassopoulos, and Maria Kapsokefalou. "The Nutritional Composition of Natural and Organic Branded Food Products: A Cross-Sectional Analysis of the Greek Foodscape." Nutrients 14, no. 4 (February 14, 2022): 808. http://dx.doi.org/10.3390/nu14040808.
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Modern consumers turn to foods marketed as ‘natural/organic’ in their pursuit of healthier options. However, research that links such claims made on pack with improved nutritional composition is limited. The current analysis used data from all packaged foods available in the Hellenic Food Thesaurus (n = 4002), sold in Greece from 09/2020 to 01/2021, to map the prevalence of packaged foods sold under a ‘natural/organic’ claim and to compare their nutritional composition against food group matched conventional counterparts. Statistical analysis was carried out using IBM SPSS Statistics®. Overall, ‘free from’ was the most commonly used claim (12.3%), followed by ‘natural/pure’ (9.1%), ‘fresh’ (4.6%), and ‘bio/organic’ (3.3%). Statistically significant differences between the nutritional composition of natural/organic and conventional foods were only found in 5 out of the 13 food categories and in 9 out of 39 subcategories. Being labelled as natural/organic was linked to improved nutritional composition for prepared foods and yogurts, while for breakfast cereal, there was a mixed effect with lower carbohydrate content but higher energy and fat content. Jams labelled as natural/organic had higher energy and total sugar content. Overall, evidence of an association between being labelled as natural/organic and having an improved nutritional composition was extremely rare.
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Soares, Cintia da Cunha, and Maria das Graças Ferraz Bezerra. "A gestão da concessão florestal no estado do Pará." Research, Society and Development 11, no. 1 (January 4, 2022): e18811125101. http://dx.doi.org/10.33448/rsd-v11i1.25101.
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O presente trabalho teve por objetivo descrever o desempenho do órgão gestor do estado do Pará na implementação da concessão florestal; a partir do monitoramento dos contratos de concessão florestal nas florestas públicas denominadas como Conjunto de Glebas Mamuru-Arapiuns e Floresta Estadual do Paru. Os estudos foram realizados em florestas públicas, no estado do Pará, na mesorregião do Baixo Amazonas, em 09 contratos de concessão florestal. Essa pesquisa baseou-se em instrumento de cunho bibliográfico e documental, a partir de trabalhos científicos e documentos oficiais fornecidos pelo Instituto de Desenvolvimento Florestal e da Biodiversidade. Dentre os principais resultados temos o pioneirismo do estado do Pará como o único ente federativo a implantar concessão florestal em florestas não destinadas ou florestas do tipo B, desde a criação da lei de gestão de florestas públicas. Para a efetiva gestão e monitoramento o órgão gestor empenhou-se na elaboração de normativas, diretrizes, notas técnicas, pareceres técnicos que visam orientar os concessionários ao cumprimento dos contratos de concessão florestal. De forma geral, mesmo diante de inúmeras situações adversas enfrentadas, a atuação do IDEFLOR-Bio na gestão tem como propósito garantir que a concessão florestal se mantenha como uma política florestal efetiva e eficiente.
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Nahar, N., MI Hossain, MJ Uddin, and ML Rahman. "Effects of Feeding Rate on Growth and Production of Stinging Catfish, Heteropneustes Fossilis (Bloch 1974) In Cage Monoculture System." Journal of Bio-Science 30, no. 1 (January 11, 2023): 01–09. http://dx.doi.org/10.3329/jbs.v30i1.63096.
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The present study evaluated the potentiality of cage culture of stinging catfish (Heteropneustes fossilis) under different feeding regimes. Fish experiments were consists of three treatments (T1, T2 and T3), each with three replicates, and lasted for 90 days. The stocking density was 300 fry (~1.5 g) per cage. Fish were given commercial floating feed (28% crude protein) twice daily (in the morning and evening) at 5% (T1), 7% (T2) and 9% (T3) of body weight. Water quality parameters were monitored fortnightly. Mean values of water quality showed no significant difference among the treatments. Survival of stinging catfish was comparatively higher with T2 (83.1%) compared to T1 (81.6%) and T3 (79.3%). The specific growth rate was significantly higher in fish reared underT2 treatment than T1 and T3, corresponding to 1.91, 1.85 and 1.87% bwd-1, respectively. The net yield was also highest with T2 (1.74 kg) than those with T1 (1.57 kg) and T3 (1.60 kg). These data together with cost-benefit analysis among three treatments suggests that 7% feeding rate positively influence growth and production offish. Therefore, a daily feeding at 7% of body weight can be suitable for culturing stinging catfish in cages. J Bio-Sci. 30(1): 01-09, 2022 (June)
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Ekundayo, FO, IA Osibote, EA Ekundayo, and OY Lauck. "Biodegradative and antimicrobial activities of pseudomonas isolated from soil and water samples in Ado-Ekiti metropolis, Nigeria." Journal of Bio-Science 22 (October 21, 2016): 9–14. http://dx.doi.org/10.3329/jbs.v22i0.30003.
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Context: The release of petroleum hydrocarbon and pesticides into the environment is a major concern because of their toxigenic and carcinogenic potentials. Microorganisms which are biodegradable and most often less toxic have been found to use these materials as carbon sources. Also, the development of resistance of microbial pathogens to commercial antibiotics has necessitated an alternative to commercial antibiotics.Objectives: This study investigated the ability of Pseudomonas species isolated from soil and water samples to degrade some petroleum products and pesticides as well as its antimicrobial potency against selected pathogens.Materials and methods: Pseudomonas species were isolated from soil samples from mechanic workshop, dump sites and stream water. The isolates were tested for the ability to degrade petroleum products (diesel, engine oil and kerosene) and some pesticides. These isolates were also tested for antimicrobial activities against some pathogenic bacteria and fungi.Results: Three Pseudomonas were obtained from the samples; Pseudomonas fluorescens (DS) was isolated from a dumping site and two Pseudomonas aeruginosa, MW and SW were isolated from mechanic workshop and stream water. The three isolates showed varying ability to degrade petroleum products and pesticides. Escherichia coli, Proteus mirabillis and Serratia marcescens were susceptible to the three Pseudomonas isolates in varying degree while Staphylococus aureus and Klebsiella pneumoniae were resistant to the isolates. All the fungi except Candida albicans were susceptible to the Pseudomonas spp.J. bio-sci. 22: 09-14, 2014
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Ahmad, I., MNA Mamun, MS Islam, R. Ara, MAA Mamdud, and AKMR Hoque. "Effect of different pruning operations on the incidence and severity of various diseases of tea plant." Journal of Bio-Science 24 (July 18, 2018): 1–9. http://dx.doi.org/10.3329/jbs.v24i0.37482.
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To analyze the effect of different pruning operation on the incidence and severity of different diseases of tea (Camellia sinensis) plant. An experiment was carried out at the Bilashchara Experimental Farm of Bangladesh Tea Research Institute (BTRI), Srimangal. Three places of the sections were selected randomly that received LP (Light Prune), DSK (deep skiff), MSK (medium skiff) and LSK (light skiff) operations. Every bush was critically observed before and after pruning operations and all infected diseases were recorded. Disease severity was expressed as percent disease index (PDI). MSTAT program was used for statistical snalysis. After pruning operation, maximum incidence 33.33% and severity 8.20% of Grey brown blight was found in LSK. Horse hair blight maximum incidence (18%) and maximum severity (6.27%) both were found in LSK. In thread blight maximum incidence was in MSK 22.67% and maximum severity was 7% in LSK. The highest % reduction of branch canker both in incidence and severity was observed in LP section followed by DSK, MSK and LSK. In case of Gall disease maximum incidence and severity both was LSK 24.67% and 7.60%. The highest incidence of black rot was in LSK 41.33% and severity 12.87% was in MSK. From the study, it was recommending that without using any chemicals, only by different pruning operations and proper cleaning can reduce the in incidence and severity of those diseases.J. bio-sci. 24: 01-09, 2016
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Raza, Syed Shehzad, Muhammad Umar Manzoor, Faraz Hussain, Tahir Ahmad, and Fahad Riaz. "Synthesis and Characterization of Nano Hydroxyapatite from Waste Egg Shells for Orthopedic and Dental Applications." Journal of the Pakistan Institute of Chemical Engineers 48, no. 2 (February 16, 2021): 31–38. http://dx.doi.org/10.54693/piche.04824.
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Hydroxyapatite (HAp) is a type of material that is widely used in orthopedic and dentistry as a bio-coating of implants for improvement in its osteointegration with bone tissue. HAp was processed and synthesized by a precipitation technique by utilizing a biological means eggshell. The synthesis technique involved the calcination of eggshell powder to obtain calcium oxide and then its titration at a controlled flow rate with phosphoric acid. Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray diffraction (XRD) investigations were carried out to confirm the formation of HAp. Whereas, the Scanning Electron Microscopy (SEM) demonstrated the shape and structure of the as-synthesized nanohydroxyapatite powder. The obtained results correlate with the literature. It was observed that the HAp formed was highly crystalline and all the peaks corresponded with HAp based on the standard XRD pattern of HAp (JCDPS card no. 09-432). It was clear from the small peaks that some Tri-Calcium Phosphate was also formed along with the hydroxyapatite. Very less crystallinity can be seen in the SEM micrograph of the eggshell. The nHAp formed was subjected to thermal treatment in a controlled environment. The thermal treatment resulted in improved crystallinity and refined grain size. It is noted that higher surface area biogenic HAp with highly interconnected nanoparticles will be useful in bone morphogenesis during bone surgery.
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Wan Ismail, Wan Norfazilah, Mohamad Irfan Arif Irwan Syah, Nur Hanisah Abd Muhet, Nurul Hidayah Abu Bakar, Hartina Mohd Yusop, and Nurlin Abu Samah. "Adsorption Behavior of Heavy Metal Ions by Hybrid Inulin-TEOS for Water Treatment." Civil Engineering Journal 8, no. 9 (September 1, 2022): 1787–98. http://dx.doi.org/10.28991/cej-2022-08-09-03.
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The present work reports the adsorption behavior involved in the adsorption of heavy metal ions using a hybrid inulin-tetraethoxysilane (TEOS) adsorbent produced through the sol-gel process. An aqueous multi-element solution was used in order to examine the inulin-TEOS adsorbent efficiency in removing Cd2+, Co2+, and Ni2+ ions. The effects of the contact duration, adsorbent dosage, initial concentration, and solution pH on the adsorption of the targeted metal ions in batch systems were evaluated. The optimal conditions for the removal of all targeted heavy metals were as follows: 30 mg of an adsorbent dosage at pH 4 and 5 minutes of contact time with an initial concentration of 0.5 mg/L. A one-way analysis of variance (one-way ANOVA) with a replication test showed that all parameters had significant differences at a p-value of 0.05. At the optimum condition, 92.59%, 90.27%, and 86.472% of Cd2+, Ni2+, and Co2+ were removed, respectively. Findings from kinetic studies suggest that the pseudo-second order model can successfully describe the overall adsorption process. Additionally, the adsorption process can be adequately explained using an intra-particle diffusion model with diffusion rate constants following the sequence of Kint,1 > Kint,2 for Co2+ and Ni2+ and Kint,1 > Kint,2 > Kint,3 for Cd2+ in each step. The results suggest that Ni2+ fits with the Langmuir isotherm, while Cd2+ and Co2+ better fit the Freundlich one. Finally, the adsorbent can be reused and is able to retain a good percentage of removal, with percentage difference decreases of 1.99%, 3.29%, and 4.12% for Cd2+, Ni2+, and Co2+, respectively, after the fifth cycle. The hybrid inulin-TEOS bio-sorbent has good adsorption capacity and durability, which could offer a low-cost practical cleaner production process for removing targeted analytes from wastewater. Doi: 10.28991/CEJ-2022-08-09-03 Full Text: PDF
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MOHAN, Bala, Sheela PRIYADARSHINEE, Ramaswamy KALPANA, and Periyakali Saravana BHAVAN. "IMPACT OF SEASONAL CHANGES IN FRESHWATER PHYTOPLANKTON AND ZOOPLANKTON BIODIVERSITY AT VALANKULAM LAKE, COIMBATORE DISTRICT, TAMIL NADU, INDIA." Journal of Applied Life Sciences and Environment 55, no. 3 (191) (February 27, 2023): 271–92. http://dx.doi.org/10.46909/alse-552063.
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The plankton communities are important source of food for the aquatic organisms, and if any undesirable changes in aquatic environment may affect plankton diversity and density. Therefore, assessment of planktonic communities in the freshwater ecosystems is essential because they serve as bio-indicators of water quality parameters. Hence, the present research was focused to evaluate the freshwater phytoplankton and zooplankton diversity and their abundance in Valankulam Lake (Lat. 10.59° N and Long. 76.57° E), at Coimbatore city, Tamil Nadu, India. Results from the study revealed that a total of 77 species of phytoplankton and zooplankton were recorded, under 37 families and 46 genera. In addition to that, a total of 43 phytoplankton species were recorded under 25 families and 30 genera, (which includes; 15 species of Cyanophyceae, 17 species of Chlorophyceae, 08 species of Bacillariophyceae, 03 species of Euglenophyceae). and a total of 34 species of zooplankton were recorded under 12 families and 17 genera, (which includes 13 species of Rotifera, 09 species of Cladocera, 08 species of Copepoda and 04 species of Ostracoda). The maximum plankton diversity was observed during the monsoon season and the minimum in the summer season. Results from study revealed the ecological status of the lake is categorized as moderately polluted due to the presence of municipal waste and industrial discharges into the lake water. Therefore, the assessment of planktonic communities in water bodies will be useful to monitor and maintain the water quality parameters and wealth of aquatic biota in the aquatic ecosystem.
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Peddappi Reddigari, Jayachandra Reddy, Yerikala Ramesh, and Chandrasekhar B. Kothapalli. "Formulation and evaluation of in-situ gels enriched with Tropicamide loaded solid lipid nanoparticles." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (March 12, 2018): 216. http://dx.doi.org/10.26452/ijrps.v9i1.1250.
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The present research work “Formulation and Evaluation of In-situ gels enriched with Tropicamide loaded solid lipid nanoparticles”. To overcome the problems of side effects and to increase the bioavailability of tropicamide loaded solid lipid nanoparticles are containing with suitable lipids (glycerin trimyristate, Tristearin, Phosphatidylcholine & soyabean lecithin) with stabilizers (poloxamer 188) and surfactant like polysorbate 80. The interaction between drug, lipids & polymer by performing with FTIR no incompatibility with each other. The particle morphology was carried out by SEM & AFM in solid lipid nanoparticle formulation. The particle size was ranges from 213.6 ± 2.16nm to 538.0 ± 6.53 nm. The zeta potential ranges form -18.3mV to 25.6mV. The entrapment efficiency of free tropicamide was ranges from 74.13 % to 90.17%. The drug content was ranges from 0.212mg/ml to 0.912mg/ml. The SLN formulations must be transparent white colour and semi solid consistency. The pH 7.0 to 8.0 in all formulation. The gelling strength of gels TSLNGF1 to TSLNGF12 was ranges from 72 ± 1 sec to 117 ± 2 sec. The bio adhesive force was ranges from 10.12 ±1.01 dynes/cm2 to 23.12 ± 1.91 dynes/cm2. The viscosity of prepared formulation ranges from 415 ± 1.94 cps to 652 ± 1.41 cps. The spread ability studies of all formulation were ranges from 09 gms/sec to 18 gms/sec. The Accelerated stability the formulations does not undergo any chemical Changes. In vitro Franz’s diffusion studies of SLN enriched in gels TSLNGF1 to TSLNGF12 among the various formulation best formulations was TSLNGF6; its follows first order kinetics.
Keywords: Solid Lipid Nanoparticles; Tropicamide; In- situ gels; In vitro diffusion studies
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Rešidović, Nura, Helena Filipović, Alema Mrković, Amra Semić, and Ahmedin Salčinović. "CONTAMINATION WITH HEAVY METALS AND PAH's IN SOIL IN THE CANTON SARAJEVO IN PERIOD 2009-2015." Radovi Šumarskog fakulteta Univerziteta u Sarajevu 21, no. 1 (October 1, 2016): 325–34. http://dx.doi.org/10.54652/rsf.2016.v1.i1.309.
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UDK 631.453(497.6)
In accordance with the role and importance of which in the world and in our country is attached to soil as a bio production factor, the need to examine and protect soil from contamination is imposed. Heavy metals are very common contaminants of soils. Highly toxic and carcinogenic PAHs are natural components of raw petro chemical compounds. Due to their negative influence on plants and animal world as well as on human population, it is necessary to evaluate and determine heavy metals and PAHs content in soils, especially in ones intended for agricultural production.
In this work, we have examined agricultural and urban soils in the Canton Sarajevo, for content of heavy metals and polycyclic aromatic hydrocarbons. Analyzed samples were in scattered state, taken from a depth of 0-30 cm. The total number of determined soil samples was one hundred and twenty (120), in the period of 2009-2015.
According to determined general chemical characteristics, soils are from slightly acetous to slightly alkaline. According to mechanical texture composition, examined soils have showed the following texture marks by Ehwald: clay and sandy loam.
Using flame/electrothermal atomic absorption spectrometry and gas chromatography with FID detection we have established the content of seven heavy metals and polycyclic aromatic hydrocarbons. In determining the content of heavy metals following methods were used: BAS ISO 11466:2000 and BAS ISO 11047:2000, and for PAHs the method was BAS ISO 18287:2008. Results were compared with the limit values from "Regulation on determining the allowable amounts of harmful and dangerous substances in soils and methods of their examination" specified in Official Gazette of the Federation of B&H, No. 72/09.
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Osoegawa, A., Y. Takeda, T. Kometani, K. Ondo, S. Fukuyama, F. Hirai, K. Nosaki, T. Seto, S. Oda, and Y. Ichinose. "LKB1 mutations in mucinous bronchioloalveolar carcinoma occurring in Peutz-Jeghers syndrome patients." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 11047. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11047.
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11047 Background: Mutations in the gene encoding Liver Kinase B1, LKB1, are common in patients with Peutz-Jeghers syndrome (PJS), which is characterized by mucocutaneous pigmentation, intestinal polyps and a high incidence of cancers at variable sites (colorectal, gynecological, breast, pancreas, and lung). Although tumors occurring in PJS patients are known to contain mucin-rich conmponents, mucinous bronchioloalveolar carcinomas (mBACs) arising from the PJS background have only rarely been reported. Here we report two mBAC patients with PJS. We further explored the LKB1 gene in these two patients and, in addition, eight sporadic mBAC patients. Methods: Frozen tissue specimens were collected from ten mBAC patients who underwent surgery in our department from 2002 to 2008, and high molecular weight genomic DNA was extracted from them and stocked in the bio-bank. Written informed consent was obtained from each patient, and ethical approval was obtained from the IRB. The nucleotide sequence of LKB1 (EX01–09) was determined by genomic PCR-direct sequencing. Loss of heterozygosity (LOH) was analyzed by high resolution fluorescent microsatellite analysis (HRFMA) using two microsatellite markers that encompass the LKB1 locus, D19S886 and D19S565. Results: Among 11 tumors derived from the 10 patients, 9 distinct LKB1 mutations were found in 7 tumors (4 G:C to A:T transitions; 3 G:C to C:G transversions; 2 single nucleotide insetion/deletion). All of three tumors obtained from the two PJS patients harbored a same sequence alteration. Although LOH was not observed in these tumors, independent sequence alterations were found in two of the three tumors, which may suggest biallelic inactivation of LKB1 in tumors occurred in the PJS patients. Conclusions: The relatively high frequency of LKB1 mutation in mBAC patients may suggest its implication in lung carcinogenesis, at least in mBAC, and its potential as a therapeutic target. [Table: see text] No significant financial relationships to disclose.
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Angkang Shimray*, Robert, and Aaron Lungleng*. "Indigenous Knowledge of Animals, Minerals and Beverages Used as Medicines among the Tangkhul Nagas of Manipur." Indian Journal of Research in Anthropology 3, no. 1 (June 15, 2017): 37–42. http://dx.doi.org/10.21088/ijra.2454.9118.3117.5.
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Animal and its products have been an important means to successful adaptation of human throughout its evolutionary journey. Since prehistoric periods, their parts, and their products have been the source of human survival along with plant and its products. It also forms a basis for indigenous medical system and later for bio or modern medical system. Hence, before it vanishes completely from the memory of the people, the urgency to document this vast knowledge arises, as it is fast disappearing. Method: Field survey was conducted on 5 rural villages of this community, and data were obtained from 55 selected informants with the help of interview schedule. The informants include local herbalists, traditional and divine healers, cultivators, midwives, and they were all 50 years and above who were believed to be the only surviving age-group of people who still have the local medical knowledge. Result: 23 animal species and its products were reportedly used in the treatment of several diseases and ailments in the surveyed villages. These animal species belong to the classes of mammals (09), insect (03), avian (03), reptiles, amphibians, oligochaeta, malacostraca, gastropoda and chilopoda. Some of the most commonly treated diseases or ailments are burnt body, fever, mumps, measles, stone case etc. Conclusion: It was found that the use of animal and its products for medicines are no longer prevalent among the majority of the studied population, or for that matter even the knowledge itself is disappearing at a very fast pace from the general population. One may argue that it was the result of the introduction of ‘modern biomedicine’ which in fact has also been responsible on one side, on the other hand, majority of these animals have disappeared while others are continuously endangered due to unregulated and excessive hunting and clearing of their habitats. It is high time for the people including the government to realize the need to conserve animals and their habitats before it became something of the past.
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Ismahane, L., BA Khaoula, AA Rahim, M. Ibrahim, MM Seghir, H. Ayoub, and OM Laid. "Effect of Two Essential Oils From the Asteraceaes Family Against Ectomyelois Ceratoniae Zell. (Lepidoptera, Pyralidae): Case Of Artemisia Herba-Alba Asso. And Artemisia Compestris L." Journal of Bio-Science 29, no. 2 (August 4, 2021): 9–17. http://dx.doi.org/10.3329/jbs.v29i2.54950.
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The current work was done Artemisia herba-alba and Artemisia compestris essential oils harvested from the Eastern Algerian Sahara, their insecticidal characteristics against the eggs and adults of the date moth Ectomyelois ceratoniae. Indeed, two treatment modes were used; by contact application on eggs and by inhalation against adults. It appears from the results that the hatch rates were less than the hatching rate recorded in the control (96% ±00.00). The hatching rate reported on eggs treated by the highest dose (160 μl/ml) of Artemisia herba-alba and Artemisia compestris essential oils are 16.66 ± 08.81 and 37.77 ± 13.47 respectively. Statistical treatment results by the Chi-square test (χ2), attest that the treatment by A. herba-alba and Artemisia compestris essential oils at the same dose (160 μl/ml) affect significantly (χ2 = 35.62, p = 0.00 and χ2 = 21.17, p = 0.00 respectively) the hatching rate compared to the control. The sensitivity of adults to essential oils is expressed by 100% mortality rates obtained after 10 min of treatment by the highest doses (80 μl/ml and 160 μl/ml) of A. herba-alba essential oils, the same mortality rates (100%) were notified with the same doses (80 μl/ml and 160 μl/ml) after 20 min and 15 min of treatment by Artemisia compestris essential oils respectively. The dose-dependent mortality data revealed that there was a significant difference between the five doses of A. herba-alba essential oil tested except at the last treatment time (20 min) for which it was appeared p = 0.571, while for A. compestris essential oil, a significant difference was recorded with p varying between 0.00 and 0.003. The lowest LD50 value (0.09 μl/ml and 16.71 μl/ml) were noted during the longest treatment time (20 min), while the highest LD50 value (75.85 μl/ml and 263.7 μl/ml) were found during the shortest time (5 min) of A. herba-alba and A. compestris respectively. J. Bio-Sci. 29(2): 09-17, 2021 (December)
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JIANG, Tao, Qian LI, Yong-bin YANG, Guang-hui LI, and Guan-zhou QIU. "Bio-oxidation of arsenopyrite." Transactions of Nonferrous Metals Society of China 18, no. 6 (December 2008): 1433–38. http://dx.doi.org/10.1016/s1003-6326(09)60021-2.
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Hood, Anna M., Hanne Stotesbury, Simisola Fadahunsi-Oduyemi, Jamie M. Kawadler, Melanie Koelbel, Satwinder Sahota, Subarna Chakravorty, et al. "Average Lifetime Hemoglobin Concentration Improves Prediction of Cognitive Outcomes in Pediatric Patients with Sickle Cell Anemia." Blood 138, Supplement 1 (November 5, 2021): 1945. http://dx.doi.org/10.1182/blood-2021-153034.
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Abstract Background: Sickle cell anemia (SCA) is associated with cognitive challenges that often worsen as children age. Previous work has established relationships between hematological markers of disease severity (i.e., hemoglobin concentration) and various neurological outcomes, including cognitive impairment. However, most studies have related static, often isolated hemoglobin concentration (Hb) values obtained from a single time-point closest to data collection. Studies of pediatric patients with phenylketonuria and Type I diabetes have demonstrated that longitudinal change and variability in phenylalanine and glucose, respectively, are better indicators of neurological and cognitive outcomes than a single value alone. Our study aimed to be the first study of pediatric patients with SCA to examine the extent to which indices of Hb control (e.g., lifetime average and variability), collected routinely in this patient group, may provide additional prognostic information. Methods: Data were collected from pediatric patients (aged 4-18 years at enrolment) with and without SCA enrolled on the Sleep Asthma Cohort-III (SAC-III) follow-up study. SAC is a mixed retrospective-prospective study assessing the impact of nocturnal oxygen desaturation on SCA complications. The present investigation assessed participants (see Figure 1 for complete participant demographics) who underwent cognitive evaluation using Wechsler scales measuring domains of IQ, processing speed (i.e., processing speed index [PSI] and Cancellation subtest), and executive function (working memory index [WMI]). Participant demographics and appropriate medical data and history (i.e., hydroxyurea therapy, silent infarction) were obtained via questionnaires and analysis of medical records. Hb (d/L) measures assessed included average lifetime values (i.e., mean and median), variability over the lifetime (i.e., standard deviation), and the single value obtained closest to data collection. Results: Correlation analyses indicated a strong positive relationship between the mean and median Hb values along with large positive associations between the average and contemporaneous values. Small non-significant correlations were demonstrated between variability and average Hb values (see Figure 1). Initial hierarchical linear regression analyses demonstrated that neither hydroxyurea use nor silent infarct (SCI) status were predictors of any cognitive outcomes or Hb values, so they were not included in any further analyses. Separate regression analyses for each cognitive outcome found that mean lifetime Hb values was the only significant predictor of IQ (p = .04, η 2 = .13) and the Cancellation subtest (p = .005, η 2 = .22). Mean lifetime Hb values approached significance for PSI (p = .09, η 2 = .08), but was not a predictor for WMI (p = .33, η 2 = .03). Conclusion: Our study demonstrated that despite strong correlations between Hb obtained closest to testing and average lifetime values (i.e., rs = .64 and .69), only lifetime Hb predicted cognitive outcomes, particularly processing speed scores from the Cancellation subtest. Variability was not strongly related to other indices of Hb control and did not predict any cognitive outcomes. These results mirror those obtained from other pediatric populations indicating that static, one time values may not best represent clinical manifestations of chronic illness, and the choice of Hb value can differentially influence research study results and clinical prognosis. Future longitudinal work in larger samples is needed, but Hb obtained over the lifetime appears to provide a more precise picture of patients' cognitive developmental trajectory than a single contemporaneous Hb value alone. Figure 1 Figure 1. Disclosures Kirkham: Bluebird Bio: Honoraria; Novartis: Honoraria; Global Blood Therapeutics: Consultancy. Howard: Imara: Consultancy, Honoraria; Global Blood Therapeutics: Consultancy; Novartis: Consultancy, Honoraria; Resonance Health: Honoraria; Novo Nordisk: Consultancy; Agios Pharmaceuticals: Consultancy; Forma Therapeutics: Consultancy; Bluebird Bio: Research Funding.
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Wen, Jiang, Juan Liu, Guangqi Song, Limei Liu, Bo Tang, and Ziyi Li. "Effects of 6-bromoindirubin-3′-oxime on the maintenance of pluripotency of porcine embryonic germ cells in combination with stem cell factor, leukemia inhibitory factor and fibroblast growth factor." REPRODUCTION 139, no. 6 (June 2010): 1039–46. http://dx.doi.org/10.1530/rep-09-0539.
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6-Bromoindirubin-3′-oxime (BIO), which is one of the glycogen synthase kinase 3 inhibitors and a key regulator of numerous signaling pathways, was reported to be capable of maintaining the pluripotency of human and mouse embryonic stem cells. Presently, it is unknown whether BIO can influence the derivation of porcine embryonic germ (EG) cells. In this study, porcine primordial germ cells (PGCs) were isolated from gonads of 24- and 28-day embryos, and were then treated with BIO either individually or in combination with other cytokines (stem cell factor (SCF), leukemia inhibitory factor (LIF), and fibroblast growth factor (FGF); abbreviated as ‘3F’), and the effects of the treatment on the proliferation ability of porcine PGCs at early stage were examined using 5-bromo-2-deoxyuridine (Brdu) immunostaining assay. After continuous culture, the effects on the efficiency of porcine undifferentiated EG cells in the third passage and differentiated EG cells from embryoid bodies were examined as well. The results obtained through the observation of the Brdu-labeled PGCs indicated that BIO in combination with 3F resulted in a significant increase in the mitosis index, and also indicated that the BIO in combination with 3F had a higher efficiency in promoting the formation of porcine EG colony derived from porcine day 24 PGCs than BIO used either individually or in combination with LIF. In addition, BIO in combination with 3F exhibited the apparent anti-differentiation activity by reversing the differentiated EG cells to the undifferentiated status. Our results demonstrate that BIO in combination with SCF, LIF, and FGF could significantly contribute to the establishment of a porcine EG cell colony and maintain the undifferentiated status.
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Wagner-Johnston, Nina D., Stephen J. Schuster, Sven de Vos, Gilles A. Salles, Wojciech Jurczak, Nishan Rajakumaraswamy, Guan Xing, and Ajay K. Gopal. "Long-Term Follow-up of Idelalisib Monotherapy in Patients with Double-Refractory Marginal Zone Lymphoma or Lymphoplasmacytic Lymphoma/ Waldenstrom's Macroglobulinemia." Blood 134, Supplement_1 (November 13, 2019): 4006. http://dx.doi.org/10.1182/blood-2019-121936.
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Introduction: Marginal zone lymphoma (MZL) and lymphoplasmacytic lymphoma (LPL)/Waldenstrom's macroglobulinemia (WM) comprise approximately 7% and 2%, respectively, of non-Hodgkin's lymphomas (NHL) (Teras 2016). MZL is further subclassified as splenic MZL (sMZL), nodal MZL (nMZL), or extranodal MZL (eMZL). Standard first-line therapies for LPL/WM include rituximab plus an alkylating agent and/or proteasome inhibitor or ibrutinib (Castillo 2017), while standard first-line treatment for MZL varies by subtype (Rosand 2017). There are limited treatment options for patients who have relapsed after first-line therapy. Idelalisib, a selective oral inhibitor of PI3Kδ, demonstrated efficacy in indolent NHL (iNHL), including MZL and LPL/WM, at a median follow-up of 9.7 months (mos) in a phase 2 study (NCT01282424; 101-09; Gopal 2014). Here, we present the final, long-term results for patients with double-refractory MZL and LPL/WM from the 101-09 study. Methods: Eligible iNHL patients had measurable disease and were refractory to both rituximab and an alkylating agent. Refractory status was defined as lack of response to or progression of lymphoma within 6 mos of completion of preceding therapy, documented by imaging. Oral idelalisib 150 mg twice daily was administered continuously until disease progression or intolerance. Responses were evaluated by an independent review committee using standard criteria (Cheson 2007; Owen 2013). Endpoints included overall response rate (ORR), time to response, duration of response (DOR), lymph node response, progression-free survival (PFS), overall survival, and safety. The final data cutoff date was 22 Oct 2018. Results: Of 125 patients enrolled, 15 (12%) had MZL (sMZL, n = 1; nMZL, n = 5; eMZL, n = 9) and 10 (8.0%) had LPL/WM. Median age was 65 years and most were non-Hispanic (n = 24; 96%) and White (n = 23; 92%). At diagnosis, 80% of MZL and 100% of LPL/WM patients had stage IV disease. The largest lesion at baseline was ≥5 cm for 5 (33%) MZL and 3 (30%) LPL/WM patients. Baseline median IgM level was elevated for 80% of LPL/WM patients (median 1.9, IQR 1.0-2.7 g/dL). Baseline beta2-microglobulin level was >3 µg/mL for 1 of 9 LPL/WM patients with values recorded (median 2.5 [range 1.7-3.1] µg/mL). For MZL and LPL/WM patients, 7 (47%) and 7 (70%) had ≥3 prior therapies, respectively. Common regimens for all 25 patients included rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone (44%), rituximab-cyclophosphamide-vincristine-prednisone (40%), rituximab only (28%), bendamustine only (24%), and bendamustine-rituximab (20%). For MZL, the ORR (95% confidence interval [CI]) was 47% (21%, 73%), with median duration of therapy of 6.4 (range 1.8-37) mos. Of 7 responders, 1 had a complete response and 6 had partial responses (PR). Seven had stable disease (SD) and 1 had progressive disease (PD). Fourteen (93%) patients had reduction in lymph nodes, with 8 (53%) having ≥50% reduction in the sum of the products of the greatest perpendicular diameters (SPD). Median PFS was 6.6 (95% CI 3.5, 22) mos and median DOR was 18 (range 0-18) mos (Table). For LPL/WM, the ORR (95% CI) was 80% (44%, 98%), with a median duration of therapy of 29 (range 6.4-51) mos. Of 8 responders, 7 had PR and 1 had a minor response. There was 1 SD and 1 PD. Nine (90%) patients had lymph node reduction, with 5 (50%) having ≥50% reduction in SPD. Median PFS was 22 (95% CI 1.4, 56) mos and median DOR was 20 (range 1.7-50) mos (Table). All 25 patients had ≥1 treatment-emergent adverse event (TEAE), 16 (64%) had a serious AE, and 11 (44%) had dose reduced due to a TEAE. Grade ≥3 TEAEs occurred for 22 (88%) patients; neutropenia (n = 7, 28%), diarrhea (7, 28%), alanine aminotransferase increased (4, 16%), asthenia (3, 12%), and pneumonia (3, 12%) were the most frequent. All patients eventually discontinued treatment due to disease progression (14, 56%), AE (6, 24%), death (3, 12%), investigator request (1, 4%), or other (1, 4%). Ten patients have died, 3 during the study and 7 during the long-term follow-up. Conclusions: Monotherapy with idelalisib showed high rates of antitumor activity in this small subset of patients with MZL and LPL/WM refractory to prior therapy with rituximab and an alkylating agent; prolonged disease control was achieved for LPL/WM patients. No new safety signals were identified despite longer follow-up. Disclosures Wagner-Johnston: Bayer: Membership on an entity's Board of Directors or advisory committees; Jannsen: Membership on an entity's Board of Directors or advisory committees; Gilead: Membership on an entity's Board of Directors or advisory committees; ADC Therapeutics: Membership on an entity's Board of Directors or advisory committees. Schuster:Genentech: Honoraria, Research Funding; Celgene: Honoraria, Research Funding; Novartis: Honoraria, Patents & Royalties: Combination Therapies of CAR and PD-1 Inhibitors with royalties paid to Novartis, Research Funding; AstraZeneca: Honoraria; Pharmacyclics: Honoraria, Research Funding; Merck: Honoraria, Research Funding; Acerta: Honoraria, Research Funding; Loxo Oncology: Honoraria; Nordic Nanovector: Honoraria; Pfizer: Honoraria; AbbVie: Honoraria, Research Funding; Gilead: Honoraria, Research Funding. de Vos:Verastem: Consultancy; Portola Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Bayer: Consultancy. Salles:Epizyme: Consultancy, Honoraria; Roche, Janssen, Gilead, Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Educational events; Amgen: Honoraria, Other: Educational events; BMS: Honoraria; Merck: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Educational events; Novartis, Servier, AbbVie, Karyopharm, Kite, MorphoSys: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Educational events; Autolus: Consultancy, Membership on an entity's Board of Directors or advisory committees. Jurczak:Bayer: Research Funding; AstraZeneca: Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Research Funding; Sandoz: Membership on an entity's Board of Directors or advisory committees, Research Funding; Novo Nordisk: Research Funding; Celtrion: Research Funding; MorphoSys: Research Funding; Gilead: Research Funding; Roche: Research Funding; Servier: Research Funding; Takeda: Research Funding; TG Therapeutics: Research Funding; Loxo: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding. Rajakumaraswamy:Gilead Sciences, Inc.: Employment. Xing:Gilead Sciences, Inc.: Employment. Gopal:Seattle Genetics, Pfizer, Janssen, Gilead, Sanofi, Spectrum, Amgen, Aptevo, BRIM bio, Acerta, I-Mab-pharma, Takeda, Compliment, Asana Bio, and Incyte.: Consultancy; Teva, Bristol-Myers Squibb, Merck, Takeda, Seattle Genetics, Pfizer, Janssen, Takeda, and Effector: Research Funding; Seattle Genetics, Pfizer, Janssen, Gilead, Sanofi, Spectrum, Amgen, Aptevo, BRIM bio, Acerta, I-Mab-pharma, Takeda, Compliment, Asana Bio, and Incyte: Honoraria. OffLabel Disclosure: Idelalisib is a selective oral inhibitor of PI3K-delta that has shown antitumor activity in previously treated indolent non-Hodgkins lymphomas in phase 1 and 2 studies. It is approved for treatment of relapsed follicular lymphoma that has progressed on 2 prior systemic therapies, relapsed chronic lymphocytic leukemia in combination with rituximab when rituximab alone would be considered appropriate due to other comorbidities, and relapsed small lymphocytic lymphoma that has progressed on 2 prior systemic therapies. In this presentation, we provide results of 2 less common subgroups of indolent non-Hodgkins lymphoma, Âmarginal zone lymphoma and lymphoplasmacytic lymphoma/Waldenstrom's Macroglobulinemia, Âfrom the completed phase 2 trial with long-term follow-up.
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Paudel, Madhu, and Deepa Timsina. "IMPACT OF CLIMATE CHANGE ON CROPPING SYSTEM AND ADAPTATION STRATEGIES UNDERTAKEN BY INDIGENOUS COMMUNITY: A CASE STUDY FROM JIRI MUNICIPALITY, DOLAKHA, NEPAL." International Journal of Agriculture and Environmental Research 08, no. 05 (2022): 573–605. http://dx.doi.org/10.51193/ijaer.2022.8501.
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Climate change is a proven and burning issue in world. It has visibly impacting different nation. The study was focused to assess the impact of climate change on cropping system and adaptation strategies undertaken by indigenous community in Jiri Municipality of Dolakha district, Nepal in 2022, which was dominated by the indigenous community namely Jirel. In survey, 212 households were selected from five wards of Jiri Municipality using purposive sampling technique. Preliminary study, scheduled questionnaire survey, field observation, focus group discussion and key informant interview were the primary information sources and secondary information were collected and analyzed using SPSS software; Microsoft Excel and Logistic regression model. From this research on Jiri Municipality of Dolakha district of country Nepal, it is again proved that the climate at the local level has been experiencing increasing trends of both precipitation and temperature (1992-2021). Analysis of agricultural data and meteorological data (2008/09 to 2019/20) shows that the annual yield of the crops like maize, wheat, millet and potato are increasing annually. This signifies that there was positive impact to crop production of study area. At the same time series, both trend of temperature and precipitation are annually increasing. Farmers have experienced that agricultural productivity is decreasing than in the recent years because of different diseases, pest, erratic rainfall, etc. However, there was also positive impact of climate change in study area because climatic variables created favorable environment to grow cauliflower, cabbage, chilly, pumpkin, lemon, kiwi fruit and spinach which were unusual crop species of study area before. Local people’s experience part shows mixed outcomes i.e. positive as well as negative impact on agricultural production due to climate change. As per the analysis of sales of chemical fertilizers data (2014/15 to 2019/20) in the study area, there was fluctuating trend of chemical fertilizers i.e. significant decrease in the sales of urea with 107.64 Mt per year. Crop yield trend showed highly positive correlation for maize, wheat and millet whereas low positive correlation for potato along with the sales of chemical fertilizers. Majority of the respondents are practicing intercropping and planning to use hybrid seeds, pesticides, chemical fertilizers, tunnel and irrigation channel, similarly, to adapt new crops and to change planting time of crops. Whereas, 100% of the respondents were using bio fertilizers to cope with increasing climatic trend.
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Rawsthorne, Helen, Trevor G. Phister, and Lee-Ann Jaykus. "Development of a Fluorescent In Situ Method for Visualization of Enteric Viruses." Applied and Environmental Microbiology 75, no. 24 (October 23, 2009): 7822–27. http://dx.doi.org/10.1128/aem.01986-09.
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ABSTRACT Studying the interactions between enteric pathogens and their environment is important to improving our understanding of their persistence and transmission. However, this remains challenging in large part because of difficulties associated with tracking pathogens in their natural environment(s). In this study, we report a fluorescent labeling strategy which was applied to murine norovirus (MNV-1), a human norovirus surrogate, and hepatitis A virus (HAV). Specifically, streptavidin-labeled Quantum dots (Q-Dots) were bound to biotinylated capsids of MNV-1 and HAV (bio-MNV-1 and bio-HAV); the process was confirmed by using a sandwich-type approach in which streptavidin-bound plates were reacted with biotinylated virus followed by a secondary binding to Q-Dots with an emission range of 635 to 675 nm (Q-Dots 655). The assay demonstrated a relative fluorescence of 528 ± 48.1 and 112 ± 8.6 for bio-MNV-1 and control MNV-1, respectively. The biotinylation process did not impact virus infectivity, nor did it interfere with the interactions between the virus and host cells or model produce items. Using fluorescent microscopy, it was possible to visualize both bio-HAV and bio-MNV-1 attached to the surfaces of permissive mammalian cells and green onion tissue. The method provides a powerful tool for the labeling and detection of enteric viruses (and their surrogates) which can be used to track virus behavior in situ.
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Chenu, F., L. Batten, G. Zernig, E. Ladstaetter, C. Hebert, and P. Blier. "P.2.c.013 Two generic antidepressant medications and their bio-equivalence or bio-inequivalence." European Neuropsychopharmacology 19 (September 2009): S411. http://dx.doi.org/10.1016/s0924-977x(09)70635-2.
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Naudin, Claude. "Bio-Rad : un engagement pour notre santé." Revue Francophone des Laboratoires 2009, no. 414 (July 2009): 8–9. http://dx.doi.org/10.1016/s1773-035x(09)70058-9.
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Niwa, Makoto, Nozomu Koseki, Yoshitaka Hashimoto, Tsuyoshi Mayumi, Naohiro Nishimura, Masahiro Satsukawa, Takahide Uchimura, Yutaka Yasuda, and Hiroyuki Yokoi. "Survey on the tiered approach for Japanese bioanalysts operated by Japan bioanalysis forum DG2014-09." Bioanalysis 8, no. 2 (January 2016): 93–98. http://dx.doi.org/10.4155/bio.15.236.
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Ab Latif, Najibah, and Salmiah Kasolang. "Wetting property of Pistia stratiotes." Industrial Lubrication and Tribology 69, no. 3 (May 8, 2017): 399–403. http://dx.doi.org/10.1108/ilt-09-2016-0219.
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Purpose The purpose of this study is to conduct an investigation into the potential characteristics of Pistia stratiotes at different maturity stages. The focus of interest was to specifically look at oleophilicity properties based on contact angle (CA) measurement. Design/methodology/approach The morphological characteristics were also examined using a variable pressure scanning electron microscope. Three different oils, namely, Bio Oil 1, Bio Oil 2 and MP-R 10W/40 semi-synthetic oil, were tested on the Pistia leaf surface to measure the CA and wetting properties. Findings It was found that both types of bio oils had distinct CA values compared to that of the synthetic oil. A maximum difference of 65° to 75° was recorded in CA values. Originality/value Based on the results, the maturity of leaves was found to affect the CA values.
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Valentini, V., and E. Ippolito. "147 Clinical status of bio-imaging for radiotherapy." European Journal of Cancer Supplements 7, no. 2 (September 2009): 37. http://dx.doi.org/10.1016/s1359-6349(09)70129-6.
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Zips, D., A. Yaromina, and M. Baumann. "149 Validation of bio-imaging methods for radiotherapy." European Journal of Cancer Supplements 7, no. 2 (September 2009): 37. http://dx.doi.org/10.1016/s1359-6349(09)70131-4.
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JIANG, Xiaoxiang, Naoko Ellis, and Zhaoping ZHONG. "Characterization of Pyrolytic Lignin Extracted from Bio-oil." Chinese Journal of Chemical Engineering 18, no. 6 (December 2010): 1018–22. http://dx.doi.org/10.1016/s1004-9541(09)60162-2.
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Hood, Anna M., Aimee K. Hildenbrand, Joanna Rebitski, Jasmine Stallworth, Yolanda Johnson, Stacey Gomes, Catharine Whitacre, et al. "Effects of the COVID-19 Pandemic on Caregivers of Young Children with Sickle Cell Disease Enrolled in the Engage-HU Trial." Blood 138, Supplement 1 (November 5, 2021): 1891. http://dx.doi.org/10.1182/blood-2021-152722.
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Abstract Background: Hydroxyurea (HU) is the primary medication used to prevent the significant medical and neurologic morbidities of pediatric sickle cell disease (SCD; HbSS or HbSB0 thalassemia). Despite the benefits of HU, it remains under-utilized likely due to lack of clinician knowledge/training and negative caregiver perceptions. Thus, we developed the Engage-HU randomized controlled trial (NCT03442114) as a novel approach to address HU utilization barriers. Engage-HU is designed to assess how clinicians can engage caregivers in a shared discussion that considers their values, preferences, and scientific evidence about HU. The COVID-19 pandemic has resulted in significant changes to healthcare delivery for children with SCD, as they are at increased risk of severe illness from COVID-19 infection. Given their risk status, it was recommended that patients with SCD complete telehealth visits when possible. Some families also chose to delay care because they feared their child would get infected at hospitals/healthcare clinics that care for COVID-19 positive patients. Since the lives of all families enrolled in the Engage-HU trial have been affected to some extent, we incorporated measures to capture the impact of the COVID-19 pandemic and the usability of telemedicine implementation and services. Methods: Engage-HU is a randomized control trial comparing two dissemination methods for clinicians to facilitate shared decision-making with caregivers of young children with SCD. Study outcomes include caregiver confidence in decision-making and perceptions of experiencing shared decision-making as well as HU uptake and child health outcomes. Eligible children are 0 to 5 years, candidates for HU, and their caregiver has not decided about HU in the past 3 months. The trial is being conducted at 9 sites in the United States and uses a unidirectional crossover design. The primary endpoints are caregiver decisional uncertainty and caregiver perception of shared decision-making measured using validated tools. Data will be analyzed using the intent-to-treat principle, and all participants will remain in the arm to which they were randomized. A multiple group comparison analysis will be performed to assess significant response variable differences by group randomization. The Engage-HU study aims to recruit 174 caregivers who are considering initiating HU. The trial is being conducted at 9 sites in the United States. Data collection is ongoing, and 160 caregiver-participants have been enrolled to date. Since May 2020, caregiver-participants have completed the COVID-19 Exposure and Family Impact Scales (CEFIS), which contain 2 subscales (exposure to potentially traumatic aspects of the pandemic, impact on families), and the COVID-19 telemedicine use survey during a study visit. Results: Currently, 8 of the 9 sites have collected data from 48 caregivers (93.8% mothers), most of whom (93.8%) identify as African American/Black (see Figure 1). Correlations indicated that older caregivers experienced greater exposure (Mean = 7.0, SD = 4.1, range = 1-19) to potentially traumatic aspects of the pandemic (r = .31, p = .04). Distress related to COVID-19 varied widely across the sample, for both caregivers (Mean = 5.9, SD = 2.9, range = 1-10) and children (Mean = 4.1, SD = 3.4, range = 1-10). Scores on the telemedicine usability survey were generally high, indicating that caregivers are happy with the quality of care delivered via telehealth. However, caregivers (r = .30, p = .09) and children (r = .32, p = .07) experiencing more pandemic-related distress reported less satisfaction with telehealth. Conclusion: Although Engage-HU has resumed research operations, recruitment has not reached pre-pandemic targets, as fewer eligible patients are scheduled for routine care visits at SCD clinics. Our preliminary analyses suggest a significant continued impact of the pandemic on families and general satisfaction with the quality of healthcare delivered via telemedicine. These findings indicate that targeted screenings to identify and intervene for those who demonstrate more COVID-19 pandemic-related distress are needed. Figure 1 Figure 1. Disclosures Quinn: Forma Therapeutics: Consultancy; Aruvant: Research Funding; Novo Nordisk: Consultancy; Emmaus Medical: Research Funding. Yates: Agios Pharmaceuticals: Current Employment. Badawy: Sanofi Genzyme: Consultancy; Vertex Pharmaceuticals Inc: Consultancy; Bluebird Bio Inc: Consultancy. Thompson: bluebird bio, Inc.: Consultancy, Research Funding; Baxalta: Research Funding; Biomarin: Research Funding; Celgene/BMS: Consultancy, Research Funding; CRISPR Therapeutics: Research Funding; Vertex: Research Funding; Editas: Research Funding; Graphite Bio: Research Funding; Novartis: Research Funding; Agios: Consultancy; Beam: Consultancy; Global Blood Therapeutics: Current equity holder in publicly-traded company. Smith-Whitley: Global Blood Therapeutics: Current Employment. King: National Cancer Institute: Research Funding; National Heart, Lung, and Blood Institute: Research Funding; Health Resources and Services Administration: Research Funding; Global Blood Therapeutics: Research Funding. Meier: CVS Caremark: Consultancy; Forma Therapeutic: Membership on an entity's Board of Directors or advisory committees; NovoNordisk: Membership on an entity's Board of Directors or advisory committees; Novartis,: Other: Data Safety Monitoring Board membership; NHLBI: Other: Data Safety Monitoring Board membership; Global Blood Therapeutics: Other: Steering Committee membership, grant funding; CDC,: Other: grant funding; Indiana Department of Health: Other: grant funding . Tubman: Global Blood Therapeutics: Consultancy, Research Funding; Novartis Pharmaceuticals: Honoraria, Research Funding; Forma Pharmaceuticals: Consultancy; Perkin Elmer: Honoraria. Crosby: Forma Therapeutics: Honoraria; PCORI: Research Funding; HRSA: Research Funding; Global Blood Therapeutics Panel: Honoraria; Children's Hospital of Philadelphia: Honoraria; Professional Resource Exchange: Patents & Royalties: $30-$60 every other year; SCDAA: Honoraria; NHLBI: Other: Payment for review of LRP Proposals, Research Funding. OffLabel Disclosure: Hydroxyurea has been FDA approved for the treatment of sickle cell disease for patients ages 2 years and above but NHLBI and ASH Guidelines recommend it be offered to children as young as age 9 months.
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Micallef, Gordon. "Elastomer selection for bio-fuel requires a systems approach." Sealing Technology 2009, no. 1 (January 2009): 7–10. http://dx.doi.org/10.1016/s1350-4789(09)70022-4.
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Roslan, Sharul Hafiq, Sharifah Bee Abd Hamid, and Nurin Wahidah Mohd Zulkifli. "Synthesis, characterisation and tribological evaluation of surface-capped molybdenum sulphide nanoparticles as efficient antiwear bio-based lubricant additives." Industrial Lubrication and Tribology 69, no. 3 (May 8, 2017): 378–86. http://dx.doi.org/10.1108/ilt-09-2016-0212.
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Purpose The purpose of this study is to synthesise and characterise surface-capped molybdenum sulphide (SCMS) nanoparticles using the solvothermal method and to investigate their tribological behaviour towards friction improver and wear reduction for bio-based lubricant oil additives. Design/methodology/approach The design of the experiment was to use freshly prepared molybdenum (II) acetate, thioacetamide, fatty acid and hexane as the solvent inside an autoclave vessel which is heated at high temperature and pressure. Various types of fatty acids were used as the capping agent, such as caproic, lauric, stearic and oleic acid. The SCMS nanoparticles formed were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffractometry, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy and thermal gravimetric analysis. These nanoadditives were then blended into pentaerythrityl tetracaprylate/caprate ester at 0.05 Wt.% concentration. The formulated bio-based lubricant oil samples were tested for viscosity, viscosity index (VI) and density based on standard method ASTM D445 and ASTM D2270. A four-ball test was carried out for determination of coefficient of friction and wear scar diameter. The wear scar formed on the surface of the ball bearing was analysed using scanning electron microscopy. Findings The characterisation results showed that SCMS nanoparticles were successfully formed with amorphous ball-like structure, and the presence of the capping layer surrounding the nanoparticles was confirmed. Then, the formulated bio-based lubricant oil with addition of nanoadditives displays improved tribological properties in term of VI, antifriction and wear reduction. Originality/value This research provides a synthesis method of producing SCMS nanoparticles using the organomolybdenum complex as the chemical precursor through the solvothermal reaction approach. Besides that, it also gives an alternative antifriction and antiwear nanoadditive for formulation of the bio-based lubricant oil.
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Ballard, E. L., R. G. Dietzgen, L. I. Sly, C. Gouk, C. Horlock, and M. Fegan. "Development of a Bio-PCR Protocol for the Detection of Xanthomonas arboricola pv. pruni." Plant Disease 95, no. 9 (September 2011): 1109–15. http://dx.doi.org/10.1094/pdis-09-10-0650.
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A real-time SYBR Green I assay was developed and evaluated as a biological and enzymatic polymerase chain reaction (Bio-PCR) protocol for the detection of Xanthomonas arboricola pv. pruni. Suppression subtractive hybridization was used to generate a X. arboricola pv. pruni-specific subtracted DNA library, using X. arboricola pv. corylina as the driver strain. Primer pair 29F/R, designed from cloned sequence, showed no homology to GenBank sequences and amplified a 344-bp product in all X. arboricola pv. pruni isolates. Compared with other published X. arboricola pv. pruni primers, this primer pair was shown to be the only one capable of differentiating X. arboricola pv. pruni from all other X. arboricola pathovars. A real-time assay was developed and shown to be capable of detecting less than 10 CFU and 0.1 pg of DNA. Epiphytic bacteria isolated from plum tissue was used to further evaluate the specificity of the assay. A Bio-PCR protocol, developed for field evaluation, confirmed X. arboricola pv. pruni isolation from asymptomatic and symptomatic plum tissue over a 9-week period between host flowering and the first appearance of leaf and fruit symptoms in an orchard. Dilution plating enabled X. arboricola pv. pruni numbers to be quantified, providing supportive evidence for the usefulness of the Bio-PCR protocol in plant pathology and quarantine surveillance.
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TAO, Xiu-xiang, Lan-ying PAN, Kai-yi SHI, CHEN-hui, Su-dong YIN, and Zhen-fu LUO. "Bio-solubilization of Chinese lignite I: extra-cellular protein analysis." Mining Science and Technology (China) 19, no. 3 (May 2009): 358–62. http://dx.doi.org/10.1016/s1674-5264(09)60067-3.
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Khoo, V. "189 (Bio) Imaging guided selection and application of personalized radiotherapy." European Journal of Cancer Supplements 7, no. 2 (September 2009): 48. http://dx.doi.org/10.1016/s1359-6349(09)70168-5.
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GUO, Xiujuan, Shurong WANG, Qi WANG, Zuogang GUO, and Zhongyang LUO. "Properties of Bio-oil from Fast Pyrolysis of Rice Husk." Chinese Journal of Chemical Engineering 19, no. 1 (February 2011): 116–21. http://dx.doi.org/10.1016/s1004-9541(09)60186-5.
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Liu, Wangyu, and Mingke Li. "A new two-step adaptive direct slicing approach for bio-scaffolds in tissue engineering." Rapid Prototyping Journal 23, no. 6 (October 17, 2017): 1170–84. http://dx.doi.org/10.1108/rpj-09-2016-0147.
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Purpose This paper aims to propose the new two-step adaptive direct slicing method for building bio-scaffold with digital micro-mirror device (DMD)-based MPμSLA systems. Design/methodology/approach In this paper, the authors proposed a new approach to directly slice a scaffold’s CAD model (i.e the three-dimensional model built by computer-aided design platforms) and save the slices’ data as BMP (bitmap, i.e. the data format used in DMD) files instead of other types of two-dimensional patterns as an intermediary. The proposed two-step strategy in this paper, i.e. a CAD model’s exterior surface and internal architecture were sliced, respectively, at first, and then assembled together to obtain one intact slice. The assembly process is much easier and convenient based on the slice data in BMP format. To achieve the adaptive slicing for both the exterior part and internal part, two new indices, the exterior surface-dominated index and internal architecture-dominated index, are, respectively, utilized as the error estimation indices. The proposed approach in this paper is developed on SolidWorks platform, but it can also be implemented on other platforms. Findings The authors found that the approach is not only more accurate but also more efficient by avoiding the repeated running of those inefficient rasterization programs. The approach is able to save computer resource and time, and enhance the robustness of slicing program, as well as is appropriate for the scaffolds’ model with internal pore architecture and external free-form surface. Practical implications Bio-scaffolds in tissue engineering require precise control over material distribution, such as the porosity, connectivity, internal pore architecture and external free-form surface. The proposed two-step adaptive direct slicing approach is a good balance of slicing efficiency and accuracy and can be useful for slicing bio-scaffolds’ models. Originality/value This paper gives supports to build bio-scaffold with DMD-based MPμSLA systems.
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Reshetylo, O., K. Nazaruk, I. Dykyy, Y. Tsaryk, I. Skyrpan, and I. Koltun. "XVII National scientific conference “Status and biodiversity of ecosystems of Shatskyi national nature park and other protected areas” dedicated to the 100 birthday anniversary of Kost Tatarynov." Visnyk of Lviv University. Biological series, no. 85 (February 25, 2021): 98–100. http://dx.doi.org/10.30970/vlubs.2021.85.11.
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XVII National scientific conference “Status and biodiversity of ecosystems of Shatskyi National Nature Park and other protected areas” dedicated to the 100 birthday anniversary of Kost Tatarynov was held on 9–12 September, 2021. Zoology Department of Ivan Franko National University of Lviv traditionally organized it. 65 participants from 40 scientific and education organizations took part in the conference. They represented Kyiv, Lviv, Kharkiv, Shatsk, Ivano-Frankove, Odesa, Sumy, Uzhgorod, Zhytomyr, Brno (Czech Republic), New-Deli (India), Copenhagen (Denmark) and others. Most of the organizations belong to the Ministry of Education and Science, National Academy of Sciences of Ukraine. Some of them represent nature protective areas of our country, animal sanctuaries and NGOs. Conference was divided into two parts: 9 September – plenary session at Biology Faculty of the University, 10–12 September – section presentations at Bio-Geographical Stationary of the University (vicinity of Shatsk, Volyn region). 29 oral reports on the actual fundamental and applied problems of zoology, ecology, hydroecology, population genetics, nature conservation, microevolution, microbiology, botany etc. were presented. At the beginning the attention was drawn to the biography of Kost Tatarynov and memories of him. One of the key conference reports was Yosyf Tsaryk’s presentation on the necessity reasons of information ecosystemology establishing as a new branch of ecology. Other reports concern global climate change and its impact on key-stone species in different ecosystems, consequences of negative anthropogenic pressure and influence of other ecological factors on biotic systems, problems and perspectives of the development of nature protected territories in Ukraine. One of the most important innovations on the conference was its mixed participation: part of the lecturers (especially those from abroad) presented their reports remotely (by Zoom), and the rest of participants did it in a traditional way. This approach gave the possibility to enlarge the list of presenters, let the organizers minimize Covid-19 risks and showed the perspective of such a conference format use for the future. Conference proceedings include 59 publications by 130 authors (https://bioweb.lnu.edu.ua/wp-content/uploads/2021/09/SHatsk-2021.pdf). The conference participants emphasized on the importance of complex approach to zoological and ecological research, necessity of integrated view on the problem of biodiversity conservation. Model sites for the following biota monitoring were chosen during the program excursion around Lake Pisochne. The participants accented on the importance of the conference as a didactic measure for students and supported the idea of popularization of zoological and ecological knowledge among schoolchildren and youth. The fact of cooperation with the scientists and institutions from abroad as well as the usage of remote technologies to communicate with them was positively mentioned too. Finally, the participants expressed their gratitude for the high level of conference organization and proposed to organize the next XVIІІ one in September of 2022. Full text of the conference resolution is available on https://bioweb.lnu.edu.ua/news/xvii-naukova-konferentsiia-stan-i-bioriznomanittya-ekosystem-shatskoho-natsionalnoho-pryrodnoho-parku-ta-inshykh-pryrodookhoronnykh-terytoriy
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Weigum, Shannon E., Pierre N. Floriano, Spencer W. Redding, Chih-Ko Yeh, Stephen D. Westbrook, H. Stan McGuff, Alan Lin, et al. "Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology." Cancer Prevention Research 3, no. 4 (March 23, 2010): 518–28. http://dx.doi.org/10.1158/1940-6207.capr-09-0139.
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Ahmad, Shabir, Hira Rashid, Qudisa Jalil, Sidra Munir, Barkatullah Barkatullah, Sulaiman Khan, Riaz Ullah, et al. "Polymers Encapsulated Aspirin Loaded Silver Oxide Nanoparticles: Synthesis, Characterization and its Bio-Applications." Sains Malaysiana 48, no. 9 (September 30, 2019): 1887–97. http://dx.doi.org/10.17576/jsm-2019-4809-09.
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