Log in

Relevant bibliographies by topics / Binge-like drinking / Journal articles

Journal articles on the topic 'Binge-like drinking'

To see the other types of publications on this topic, follow the link: Binge-like drinking.

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Binge-like drinking.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Pozhidayeva, Dar’ya Y., Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, and Angela R. Ozburn. "Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes." Brain Sciences 10, no. 2 (February 18, 2020): 109. http://dx.doi.org/10.3390/brainsci10020109.

Full text

Abstract:

Binge drinking is a dangerous pattern of behavior. We tested whether chronically manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide (CNO) and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)) could produce lasting effects on ethanol binge-like drinking in mice selectively bred to drink to intoxication. We found chronically increasing NAc activity (4 weeks, via CNO and the excitatory DREADD, hM3Dq) decreased binge-like drinking, but did not observe CNO-induced changes in drinking with the inhibitory DREADD, hM4Di. The CNO/hM3Dq-induced reduction in ethanol drinking persisted for at least one week, suggesting adaptive neuroplasticity via transcriptional and epigenetic mechanisms. Therefore, we defined this plasticity at the morphological and transcriptomic levels. We found that chronic binge drinking (6 weeks) altered neuronal morphology in the NAc, an effect that was ameliorated with CNO/hM3Dq. Moreover, we detected significant changes in expression of several plasticity-related genes with binge drinking that were ameliorated with CNO treatment (e.g., Hdac4). Lastly, we found that LMK235, an HDAC4/5 inhibitor, reduced binge-like drinking. Thus, we were able to target specific molecular pathways using pharmacology to mimic the behavioral effects of DREADDs.

APA, Harvard, Vancouver, ISO, and other styles

2

YOUNG, AMY M., MICHELE MORALES, SEAN ESTEBAN McCABE, CAROL J. BOYD, and HANNAH D'ARCY. "Drinking Like a Guy: Frequent Binge Drinking Among Undergraduate Women." Substance Use & Misuse 40, no. 2 (January 2005): 241–67. http://dx.doi.org/10.1081/ja-200048464.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Czapla, Marta, Joe J. Simon, Hans-Christoph Friederich, Sabine C. Herpertz, Peter Zimmermann, and Sabine Loeber. "Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?" European Addiction Research 21, no. 2 (November 22, 2014): 105–13. http://dx.doi.org/10.1159/000367939.

Full text

Abstract:

Background/Aims: Little is known about the association of binge drinking with impulsivity related to trait- or state-like aspects of behavior. The aim of the present study was therefore to investigate whether binge drinkers show an impairment of inhibitory control in comparison to non-binge drinkers when confronted with alcohol-associated or control stimuli, and whether this is reflected in self-reported impulsivity. Methods: A go/no-go task with pictures of alcoholic and nonalcoholic beverages as well as control stimuli was administered to binge drinkers and a gender-matched group of non-binge drinkers. All participants also completed the Barratt Impulsiveness Scale (BIS-11). Results: We found an alcohol-specific impairment of response inhibition for binge drinkers only, while the groups did not differ with regard to overall response inhibition to the experimental stimuli or self-reported impulsiveness (BIS-11). In addition, the number of commission errors in response to alcohol-associated stimuli was the only significant predictor of binge drinking. Conclusion: The findings of the present study suggest that when young adults have established binge drinking as a common drinking pattern, impairment of inhibition in response to alcoholic stimuli is the only significant predictor of binge drinking, but not general impulsive behavior. i 2014 S. Karger AG, Basel

APA, Harvard, Vancouver, ISO, and other styles

4

Gutema, Hordofa, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Tebkew Shibabaw, and Tolera Disasa. "Predicting binge drinking among university students: Application of integrated behavioral model." PLOS ONE 16, no. 7 (July 9, 2021): e0254185. http://dx.doi.org/10.1371/journal.pone.0254185.

Full text

Abstract:

Background Binge drinking is a pattern of harmful use of alcohol and it is defined as four drinks for women and five drinks for men in about 2 hours. This behavior causes public health problems like damaging different body organs. Objective To assess binge drinking and associated factors among Bahir Dar University students in Northwest Ethiopia. Method A cross sectional study was conducted in November 2017. Systematic sampling technique was used to select 422 participants. Structured questionnaire was used to collect data. Linear and Logistic regression models were used to predict the role of explanatory variables on behavioral intention and binge drinking, respectively. Independent variables with a p-value of <0.05 at 95% confidence interval were considered as statistically significant in the final model. Result A total of 413 students participated in this study and 33.4%(95% CI: 28.3–38.9) were engaged in binge drinking. Experiential attitude, instrumental attitude, and self-efficacy were found to be significant predictors of intention to binge drinking (p<0.05). Experiential attitude, environmental constraint, injunctive norm, and knowledge predictors were significantly associated with binge drinking (p<0.05). Conclusion Our study indicated that one-third of the students practiced binge drinking. This behavior was associated with experiential attitude, injunctive norm, environmental constraints, and knowledge factors. Additionally, experiential attitude, instrumental attitude, and self-efficacy constructs had explained behavioral intention. This implies focusing on the abovementioned determinant factors is imperative while designing intervention strategy.

APA, Harvard, Vancouver, ISO, and other styles

5

Grigsby, Kolter, Courtney Ledford, Tanvi Batish, Snigdha Kanadibhotla, Delaney Smith, Evan Firsick, Alexander Tran, et al. "Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression." International Journal of Molecular Sciences 23, no. 19 (September 21, 2022): 11084. http://dx.doi.org/10.3390/ijms231911084.

Full text

Abstract:

Previous studies (1) support a role of circadian genes in regulating alcohol intake, and (2) reveal that harmful alcohol use alters circadian rhythms. However, there is minimal knowledge of the effects of chronic alcohol processes on rhythmic circadian gene expression across brain regions important for circadian biology and alcohol intake. Therefore, the present study sought to test the effects of chronic binge-like drinking on diurnal circadian gene expression patterns in the master circadian pacemaker (SCN), the ventral tegmental area (VTA), and the nucleus accumbens (NAc) in High Drinking in the Dark-1 (HDID-1) mice, a unique genetic risk model for drinking to intoxication. Consistent with earlier findings, we found that 8 weeks of binge-like drinking reduced the amplitude of several core circadian clock genes in the NAc and SCN, but not the VTA. To better inform the use of circadian-relevant pharmacotherapies in reducing harmful drinking and ameliorating alcohol’s effects on circadian gene expression, we tested whether the casein kinase-1 inhibitor, PF-67046, or the phosphodiesterase type-4 (an upstream regulator of circadian signalling) inhibitor, apremilast, would reduce binge-like intake and mitigate circadian gene suppression. PF-67046 did not reduce intake but did have circadian gene effects. In contrast, apremilast reduced drinking, but had no effect on circadian expression patterns.

APA, Harvard, Vancouver, ISO, and other styles

6

Nentwig, Todd B., Colleen E. McGonigle, Diane E. Wilson, Erin M. Rhinehart, and Judith E. Grisel. "Beta-endorphin modulates binge-like ethanol drinking in mice." Alcohol 60 (May 2017): 240. http://dx.doi.org/10.1016/j.alcohol.2017.02.342.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Queiroz, Letícia Yoshitome, Igor Gonçalves de Oliveira, Sabrina de Carvalho Cartágenes, Luanna Melo Pereira Fernandes, Sávio Monteiro dos Santos, Wallax Augusto Silva Ferreira, Fernando Augusto Rodrigues Mello Junior, et al. "Repeated Cycles of Binge-Like Ethanol Exposure Induces Neurobehavioral Changes During Short- and Long-Term Withdrawal in Adolescent Female Rats." Oxidative Medicine and Cellular Longevity 2022 (October 25, 2022): 1–11. http://dx.doi.org/10.1155/2022/7207755.

Full text

Abstract:

Alcohol consumption is spread worldwide and can lead to an abuse profile associated with severe health problems. Adolescents are more susceptible to addiction and usually consume ethanol in a binge drinking pattern. This form of consumption can lead to cognitive and emotional disorders, however scarce studies have focused on long-term hazardous effects following withdrawal periods after binge drinking in adolescents. Thus, the present study aims at investigating whether behavioral and cognitive changes persist until mid and late adulthood. Female Wistar rats (9-10 animals/group) received intragastric administration of four cycles of ethanol binge-like pattern (3.0 g/kg/day, 20% w/v; 3 days-on/4 days-off) from 35th to 58th days old, followed withdrawal checkpoints 1 day, 30 days, and 60 days. At each checkpoint period, behavioral tests of open field, object recognition test, elevated plus maze, and forced swimming test were performed, and blood and hippocampus were collected for oxidative biochemistry and brain-derived neurotrophic factor (BDNF) levels analysis, respectively. The results demonstrated that adolescent rats exposed to binge drinking displayed anxiogenic- and depressive-like phenotype in early and midadulthood, however, anxiety-like profile persisted until late adulthood. Similarly, short-term memory was impaired in all withdrawal periods analysed, including late adult life. These behavioral data were associated with oxidative damage in midadulthood but not BDNF alterations. Taken together, the present work highlights the long-lasting emotional and cognitive alterations induced by ethanol binge drinking during adolescence, even after a long period of abstinence, which might impact adult life.

APA, Harvard, Vancouver, ISO, and other styles

8

Likashi, Danny Vumbi, Ravi Paul, and Luty Jason. "The Proportion of Binge Drinking Among Female Social Drinkers of Kalingalinga in Lusaka, Zambia: A Pilot Study." Global Psychiatry 2, no. 1 (March 25, 2019): 43–50. http://dx.doi.org/10.2478/gp-2019-0005.

Full text

Abstract:

AbstractObjectivesAlcohol is a psychoactive substance with dependence-producing properties. Alcohol’s harmful use causes large burden diseases like social and economic burden in societies. Binge drinking is one of the commonest forms of alcohol misuse and has been on an increase among many young women, who find alcohol a source of pleasure and enjoyment when they have timeout with friends and peers. Since binge drinking involves consumption of alcohol on an irregular basis, it may not be viewed as a hazardous form of alcohol use by many drinkers. The present study is aimed at estimating the proportion of female binge drinkers in the population of female social drinkers in Kalingalinga township of Lusaka, the capital city of Zambia. We hypothesised that the proportion of binge drinking in the population of female social drinkers is significantly high.MethodsThrough snowball sampling, 100 questionnaires (i.e., Alcohol Use Disorders Identification Test-AUDIT) were successfully distributed to and collected from the female social drinkers aged 20–39 years between August and September, 2016. A two-fold process was followed in identifying the binge drinkers; screening for hazardous alcohol drinkers by identifying those that scored 8 points or above in the first place, and thereafter, identifying binge drinking characteristics from the hazardous drinkers by following scores from the first three questions on the AUDIT.ResultsThe results reviewed that 54 of the 100 participants had some form of hazardous alcohol use and 30 of the 54 hazardous drinkers possessed some binge drinking characteristics. The proportion of female binge drinkers in a population of female alcohol drinkers was estimated to be 0.556 (56.6%), while in the general population, it was estimated to be 0.094. This implies that 9.4% of women aged 20–39 years of Kalingalinga in Lusaka engage in alcohol binge drinking, consuming on average 7–9 drinks on occasion almost on a weekly basis. Further, if 56% of all female alcohol drinkers aged 20–39 years seem to engage in some form of alcohol binge drinking, it means that that binge drinking is the highest form of alcohol misuse among these female drinkers.ConclusionThe results of the present study suggest that there is more alcohol binge drinking among the female social drinkers of Kalingalinga in Lusaka, with an estimated proportion of 0.556 (55.6%) among the female alcohol drinkers and 0.094 (9.4%) in the general population of females aged between 20–39 years. The implication is that alcohol binge drinking seems to be the highest form of alcohol misuse among female drinkers in Kalingalinga.

APA, Harvard, Vancouver, ISO, and other styles

9

Radke, Anna K., Elizabeth A. Sneddon, Raizel M. Frasier, and Frederic W. Hopf. "Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking." International Journal of Molecular Sciences 22, no. 7 (April 6, 2021): 3788. http://dx.doi.org/10.3390/ijms22073788.

Full text

Abstract:

Alcohol use disorder remains a substantial social, health, and economic problem and problem drinking levels in women have been increasing in recent years. Understanding whether and how the underlying mechanisms that drive drinking vary by sex is critical and could provide novel, more targeted therapeutic treatments. Here, we examine recent results from our laboratories and others which we believe provide useful insights into similarities and differences in alcohol drinking patterns across the sexes. Findings for binge intake and aversion-resistant, compulsion-like alcohol drinking are considered, since both are likely significant contributors to alcohol problems in humans. We also describe studies regarding mechanisms that may underlie sex differences in maladaptive alcohol drinking, with some focus on the importance of nucleus accumbens (NAcb) core and shell regions, several receptor types (dopamine, orexin, AMPA-type glutamate), and possible contributions of sex hormones. Finally, we discuss how stressors such as early life stress and anxiety-like states may interact with sex differences to contribute to alcohol drinking. Together, these findings underscore the importance and critical relevance of studying female and male mechanisms for alcohol and co-morbid conditions to gain a true and clinically useful understanding of addiction and neuropsychiatric mechanisms and treatment.

APA, Harvard, Vancouver, ISO, and other styles

10

Grigsby, Kolter B., Antonia M. Savarese, Pamela Metten, Barbara J. Mason, Yuri A. Blednov, John C. Crabbe, and Angela R. Ozburn. "Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice." Neuroscience Insights 15 (January 2020): 263310552097541. http://dx.doi.org/10.1177/2633105520975412.

Full text

Abstract:

High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, 0.5, 1, and 2 mg/kg), sirolimus (0, 5, 10, and 20 mg/kg), palmitoylethanolamide (PEA; 0, 75, 150, and 225 mg/kg), and secukinumab (0, 5, 20, and 60 mg/kg) on binge-like ethanol intake (2-day, “Drinking in the Dark” [DID]) and blood alcohol levels (BALs) in HDID-1 mice. Tacrolimus reduced ethanol intake and BALs. Tacrolimus had no effect on water intake, but reduced saccharin intake. There was no effect of sirolimus, PEA, or secukinumab on ethanol intake or BALs. These results compare and contrast with previous work addressing these compounds or their targeted mechanisms of action on ethanol drinking, highlighting the importance of screening a wide range of models and genotypes to inform the role of neuroimmune signaling in AUDs.

APA, Harvard, Vancouver, ISO, and other styles

11

Wilcox, Mark V., Verginia C. Cuzon Carlson, Nyssa Sherazee, Gretchen M. Sprow, Roland Bock, Todd E. Thiele, David M. Lovinger, and Veronica A. Alvarez. "Repeated Binge-Like Ethanol Drinking Alters Ethanol Drinking Patterns and Depresses Striatal GABAergic Transmission." Neuropsychopharmacology 39, no. 3 (September 2, 2013): 579–94. http://dx.doi.org/10.1038/npp.2013.230.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Coles, Cassandre, and Amy W. Lasek. "Binge-Like Ethanol Drinking Increases Otx2, Wnt1, and Mdk Gene Expression in the Ventral Tegmental Area of Adult Mice." Neuroscience Insights 16 (January 2021): 263310552110098. http://dx.doi.org/10.1177/26331055211009850.

Full text

Abstract:

Alcohol use disorder is associated with pathophysiological changes in the dopaminergic system. Orthodenticle homeobox 2 (OTX2) is a transcription factor important for the development of dopaminergic neurons residing in the ventral tegmental area (VTA), a critical region of the brain involved in drug reinforcement. Previous studies have demonstrated that ethanol exposure during embryonic development reduces Otx2 mRNA levels in the central nervous system. We hypothesized that levels of OTX2 would be altered by binge-like ethanol consumption in adult animals. To test this, Otx2 mRNA and protein levels in the mouse VTA were measured by quantitative real-time PCR and western blotting, respectively, after mice drank ethanol for 4 days in a procedure that elicits binge levels of ethanol consumption (drinking in the dark). Expression of known and putative OTX2 transcriptional target genes ( Sema3c, Wnt1, and Mdk) were also measured in the VTA after ethanol drinking. Otx2 mRNA and protein levels were elevated in the VTA 24 hours after the fourth drinking session and there was a corresponding increase in the expression of Mdk transcript. Interestingly, Wnt1 transcript was elevated in the VTA immediately after the fourth drinking session but returned to control levels 24 hours later. We next investigated if viral-mediated reduction of Otx2 in the mouse VTA would alter ethanol or sucrose intake. Lentiviral vectors expressing a shRNA targeting Otx2 or a control shRNA were injected into the VTA and mice were tested in the drinking in the dark protocol for ethanol and sucrose drinking. Reducing levels of OTX2 in the VTA did not alter ethanol or sucrose consumption. One limitation is that the extent of OTX2 reduction may not have been sufficient. Although OTX2 in the VTA may not play a role in binge-like drinking in adult mice, OTX2 could contribute to ethanol-induced transcriptional changes in this region.

APA, Harvard, Vancouver, ISO, and other styles

13

Robinson, Stacey L., Carlos A. Perez-Heydrich, and Todd E. Thiele. "Corticotropin Releasing Factor Type 1 and 2 Receptor Signaling in the Medial Prefrontal Cortex Modulates Binge-Like Ethanol Consumption in C57BL/6J Mice." Brain Sciences 9, no. 7 (July 19, 2019): 171. http://dx.doi.org/10.3390/brainsci9070171.

Full text

Abstract:

Corticotropin releasing factor (CRF) signaling via limbic CRF1 and 2 receptors (CRF1R and CRF2R, respectively) is known to modulate binge-like ethanol consumption in rodents. Though CRF signaling in the medial prefrontal cortex (mPFC) has been shown to modulate anxiety-like behavior and ethanol seeking, its role in binge ethanol intake is unknown. Here, we used “drinking-in-the-dark” (DID) procedures in male and female C57BL/6J mice to address this gap in the literature. First, the role of CRF1R and CRF2R signaling in the mPFC on ethanol consumption was evaluated through site-directed pharmacology. Next, we evaluated if CRF1R antagonist reduction of binge-intake was modulated in part through CRF2R activation by co-administration of a CRF1R and CRF2R antagonist. Intra-mPFC inhibition of CRF1R and activation of CRF2R resulted in decreased binge-like ethanol intake. Further, the inhibitory effect of the CRF1R antagonist was attenuated by co-administration of a CRF2R antagonist. We provide novel evidence that (1) inhibition of CRF1R or activation of CRF2R in the mPFC reduces binge-like ethanol intake; and (2) the effect of CRF1R antagonism may be mediated via enhanced CRF2R activation. These observations provide the first direct behavioral pharmacological evidence that CRF receptor activity in the mPFC modulates binge-like ethanol consumption.

APA, Harvard, Vancouver, ISO, and other styles

14

Sprow, Gretchen M., and Todd E. Thiele. "The neurobiology of binge-like ethanol drinking: Evidence from rodent models." Physiology & Behavior 106, no. 3 (June 2012): 325–31. http://dx.doi.org/10.1016/j.physbeh.2011.12.026.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Wilcox, Mark V., Verginia C. Cuzon Carlson, Nyssa Sherazee, Gretchen M. Sprow, Roland Bock, Todd E. Thiele, David M. Lovinger, and Veronica A. Alvarez. "Erratum: Repeated Binge-Like Ethanol Drinking Alters Ethanol Drinking Patterns and Depresses Striatal GABAergic Transmission." Neuropsychopharmacology 39, no. 8 (June 13, 2014): 2039–40. http://dx.doi.org/10.1038/npp.2014.54.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Sampedro-Piquero, Patricia, Carmelo Millón, Román D. Moreno-Fernández, María García-Fernández, Zaida Diaz-Cabiale, and Luis Javier Santin. "Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice." Brain Sciences 10, no. 9 (August 20, 2020): 576. http://dx.doi.org/10.3390/brainsci10090576.

Full text

Abstract:

The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely explored. We aimed to study the protective role of treadmill physical exercise on the deficits caused after repeated cycles of binge-like EtOH exposure in the cognition, motivation, exploration, and emotion of C57BL/6J mice from adolescence to adulthood. Animals were divided into four groups: control group, exercised group, EtOH group, and exercised + EtOH group (20% in tap water). The exercise was performed for 20 min, 5 days/week at 20 cm/s. Then, animals were submitted to several behavioral tasks. Compared to binge-drinking mice, the exercised + EtOH group exhibited diminished anxiolytic-related behaviors in the elevated plus-maze, enhanced exploratory activity in the open field, reduced preference for alcohol odor when another rewarding stimulus was present (social stimulus) and lower latency to start self-cleaning behaviors in the sucrose splash test. In contrast, other measurements such as habituation learning and working memory were not improved by exercise. Besides, exercise was not able to reduce alcohol consumption across the weeks. In conclusion, physical activity during adolescence and early adulthood could buffer certain neurobehavioral alterations associated with binge-drinking, despite not reducing the quantity of consumed alcohol.

APA, Harvard, Vancouver, ISO, and other styles

17

Jimenez Chavez, C. Leonardo, Michal A. Coelho, Lindsey W. Brewin, Isaiah Swauncy, Tori Tran, Taylor Albanese, Angie Laguna, Ivette Gabriela, and Karen K. Szumlinski. "Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective." Brain Sciences 10, no. 6 (June 26, 2020): 405. http://dx.doi.org/10.3390/brainsci10060405.

Full text

Abstract:

A prior history of excessive drinking induces a negative affective state in both humans and laboratory rodents, the manifestation of which varies with the age of drinking-onset. In adolescent male mice, negative affect incubates over the course of a 30-day alcohol withdrawal period. In contrast, the negative affect exhibited by adult male mice is robust at 1 day withdrawal, but dissipates with the passage of time. As females tend to consume more alcohol than males, we aimed to explore the affective disturbances exhibited by adolescent and adult C57BL/6J mice of both sexes during more protracted alcohol withdrawal and to relate any behavioral changes observed to plasma corticosterone levels as a biochemical index of stress. Male and female, adolescent and adult, mice were subjected to 14 consecutive days of binge alcohol-drinking using a multi-bottle-choice Drinking-in-the-Dark (DID) procedure (5, 10, 20 and 40% v/v). Age- and sex-matched control mice consumed water only. On either withdrawal day 1 or 70, subgroups of animals were subjected a to 1-day behavioral test battery that included the light–dark box shuttle test, marble-burying test, and Porsolt forced swim test. As expected, adolescent mice consumed more alcohol than adults and females consumed more alcohol than males. However, despite binge-like levels of alcohol consumption, we detected relatively few signs of alcohol withdrawal-induced negative affect and there was no correlation between affective behavior and circulating corticosterone levels. We discuss these findings within the context of our published work, highlighting procedural differences that might account for the relatively weak effect of binge-drinking history upon anxiety and depressive-like behavior observed herein.

APA, Harvard, Vancouver, ISO, and other styles

18

Donath, C., E. Gräßel, D. Baier, S. Bleich, and T. Hillemacher. "Alcohol use and Binge Drinking in adolescents living in Germany: A representative study - variation of consumption patterns according to migration background." European Psychiatry 26, S2 (March 2011): 31. http://dx.doi.org/10.1016/s0924-9338(11)71742-4.

Full text

Abstract:

IntroductionBinge Drinking is a constant problem behaviour in adolescents across Europe. However, epidemiological data on alcohol consumption of adolescents with different migration backgrounds are rare.Objective/aimsCreate insight on alcohol consumption patterns in adolescents with different migration backgrounds living in Germany.MethodsIn the years 2007/2008, a representative written survey of N = 44,610 students in the 9th grade of different school types in Germany was carried out (net sample). The return rate of questionnaires was 88% regarding all students whose teachers respectively school directors had agreed to participate in the study. 27.4% of the adolescents surveyed have a migration background whereby the Turkish culture is the largest group followed by adolescents who emigrated from former Soviet Union states.ResultsMore than half (57.4%) of the German 9th-graders engaged in binge drinking at least once during the 4 weeks prior to the survey. Students with migration background of the former Soviet Union showed mainly similar drinking behaviour like German adolescents (56.2%). Adolescents with Turkish roots engaged in binge drinking less frequently than adolescents of German descent (23.6%). However, in those adolescents who consumed alcohol in the last 4 weeks, binge drinking is very prominent across cultural backgrounds.ConclusionsCommon expectations concerning drinking behaviour of adolescents of certain cultural backgrounds (‘migrants with Russian background drink more’/‘migrants from Islamic imprinted countries drink less’) are only partly affirmed. Possibly, the degree of acculturation to the permissive German alcohol culture plays a role here.

APA, Harvard, Vancouver, ISO, and other styles

19

Schuh, Kristen M., Elizabeth A. Sneddon, Austin M. Nader, Marissa A. Muench, and Anna K. Radke. "Orbitofrontal cortex subregion inhibition during binge-like and aversion-resistant alcohol drinking." Alcohol 99 (March 2022): 1–8. http://dx.doi.org/10.1016/j.alcohol.2021.11.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Bell, Richard L., Zachary A. Rodd, Rebecca J. Smith, Jamie E. Toalston, Kelle M. Franklin, and William J. McBride. "Modeling binge-like ethanol drinking by peri-adolescent and adult P rats." Pharmacology Biochemistry and Behavior 100, no. 1 (November 2011): 90–97. http://dx.doi.org/10.1016/j.pbb.2011.07.017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Crabbe, John C., Jason P. Schlumbohm, Wyatt Hack, Amanda M. Barkley-Levenson, Pamela Metten, and K. Matthew Lattal. "Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking." Alcohol 52 (May 2016): 25–32. http://dx.doi.org/10.1016/j.alcohol.2016.01.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Savarese, Antonia M., Angela R. Ozburn, Pamela Metten, Jason P. Schlumbohm, Wyatt R. Hack, Kathryn LeMoine, Hazel Hunt, Felix Hausch, Michael Bauder, and John C. Crabbe. "Targeting the Glucocorticoid Receptor Reduces Binge‐Like Drinking in High Drinking in the Dark (HDID‐1) Mice." Alcoholism: Clinical and Experimental Research 44, no. 5 (March 27, 2020): 1025–36. http://dx.doi.org/10.1111/acer.14318.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Thiele, Todd E., and Montserrat Navarro. "“Drinking in the dark” (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice." Alcohol 48, no. 3 (May 2014): 235–41. http://dx.doi.org/10.1016/j.alcohol.2013.08.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Cantacorps, Lídia, Silvia Alfonso-Loeches, Consuelo Guerri, and Olga Valverde. "Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation." Journal of Psychopharmacology 33, no. 12 (June 18, 2019): 1562–72. http://dx.doi.org/10.1177/0269881119856001.

Full text

Abstract:

Background: Alcohol exposure impairs brain development and leads to a range of behavioural and cognitive dysfunctions, termed as foetal alcohol spectrum disorders. Although different mechanisms have been proposed to participate in foetal alcohol spectrum disorders, the molecular insights of such effects are still uncertain. Using a mouse model of foetal alcohol spectrum disorder, we have previously shown that maternal binge-like alcohol drinking causes persistent effects on motor, cognitive and emotional-related behaviours associated with neuroimmune dysfunctions. Aims: In this study, we sought to evaluate whether the long-term behavioural alterations found in offspring with early exposure to alcohol are associated with epigenetic changes in the hippocampus and prefrontal cortex. Methods: Pregnant C57BL/6 female mice underwent a model procedure for binge alcohol drinking throughout both the gestation and lactation periods. Subsequently, adult offspring were assessed for their cognitive function in a reversal learning task and brain areas were extracted for epigenetic analyses. Results: The results demonstrated that early binge alcohol exposure induces long-term behavioural effects along with alterations in histone acetylation (histone H4 lysine 5 and histone H4 lysine 12) in the hippocampus and prefrontal cortex. The epigenetic effects were linked with an imbalance in histone acetyltransferase activity that was found to be increased in the prefrontal cortex of mice exposed to alcohol. Conclusions: In conclusion, our results reveal that maternal binge-like alcohol consumption induces persistent epigenetic modifications, effects that might be associated with the long-term cognitive and behavioural impairments observed in foetal alcohol spectrum disorder models.

APA, Harvard, Vancouver, ISO, and other styles

25

Savina, Maria A. "Semantic Field “Alcohol Use” in Russian (In Comparison with Italian)." Critique and Semiotics 10, no. 2 (2022): 364–84. http://dx.doi.org/10.25205/2307-1737-2022-2-364-384.

Full text

Abstract:

The article characterizes the similarities of the semantic fields “alcohol use” and describes their differences on the example of lexical paradigms like “drinking alcohol in large quantities for a long time (binge drinking)”, “physical and psychological destruction as a result of drinking alcohol (become an inveterate drunkard)” and “hangover” in Russian and Italian. The study is based on the materials of the National Corpus of the Russian Language, the ContextReverse portal of works by Italian authors and various dictionaries. The author used methods of continuous sampling, corpus, comparative, modeling, the method of contextual, definitional and component analysis.

APA, Harvard, Vancouver, ISO, and other styles

26

Lamarão-Vieira, Kátia, Dinair Pamplona-Santos, Priscila C. Nascimento, Márcio G. Corrêa, Leonardo O. Bittencourt, Savio M. dos Santos, Sabrina C. Cartágenes, et al. "Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats." Oxidative Medicine and Cellular Longevity 2019 (February 18, 2019): 1–14. http://dx.doi.org/10.1155/2019/6802424.

Full text

Abstract:

Ethanol (EtOH) binge drinking is characterized by high EtOH intake during few hours followed by withdrawal. Protection strategies against the damages generated by this binge are poorly explored. Thus, this study is aimed at investigating the protective role of treadmill physical exercise (PE) on the damage caused after repeated cycles of binge-like EtOH exposure in the oxidative biochemistry, morphology, and cerebellar function of rats from adolescence to adulthood. For this, animals were divided into four groups: control group (sedentary animals with doses of distilled water), exercised group (exercised animals with doses of distilled water), EtOH group (sedentary animals with doses of 3 g/kg/day of EtOH, 20% w/v), and exercised+EtOH group (exercised animals with previous mentioned doses of EtOH). The PE occurred on a running treadmill for 5 days a week for 4 weeks, and all doses of EtOH were administered through intragastric gavage in four repeated cycles of EtOH in a binge-like manner. After the EtOH protocol and PE, animals were submitted to open field and beam walking tests. In sequence, the cerebellums were collected for the biochemical and morphological analyses. Biochemical changes were analyzed by measurement of Trolox equivalent antioxidant capacity (TEAC), reduced glutathione content measurements (GSH), and measurement of nitrite and lipid peroxidation (LPO). In morphological analyses, Purkinje cell density evaluation and immunohistochemistry evaluation were measured by antimyelin basic protein (MBP) and antisynaptophysin (SYP). The present findings demonstrate that the binge drinking protocol induced oxidative biochemistry misbalance, from the decrease of TEAC levels and higher LPO related to tissue damage and motor impairment. In addition, we have shown for the first time that treadmill physical exercise reduced tissue and functional alterations displayed by EtOH exposure.

APA, Harvard, Vancouver, ISO, and other styles

27

Satta, Rosalba, Elisa R. Hilderbrand, and Amy W. Lasek. "Ovarian Hormones Contribute to High Levels of Binge-Like Drinking by Female Mice." Alcoholism: Clinical and Experimental Research 42, no. 2 (January 8, 2018): 286–94. http://dx.doi.org/10.1111/acer.13571.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Purohit, Kush, Puja K. Parekh, Joseph Kern, Ryan W. Logan, Zheng Liu, Yanhua Huang, Colleen A. McClung, John C. Crabbe, and Angela R. Ozburn. "Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice." Alcoholism: Clinical and Experimental Research 42, no. 5 (April 18, 2018): 879–88. http://dx.doi.org/10.1111/acer.13626.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Sabino, Valentina, Pietro Cottone, Angelo Blasio, Malliga R. Iyer, Luca Steardo, Kenner C. Rice, Bruno Conti, George F. Koob, and Eric P. Zorrilla. "Activation of σ-Receptors Induces Binge-like Drinking in Sardinian Alcohol-Preferring Rats." Neuropsychopharmacology 36, no. 6 (February 23, 2011): 1207–18. http://dx.doi.org/10.1038/npp.2011.5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Jayaratne, Sarasi, Gaurang Prabhu, Ben Yoo, Nina Swiacki, and Jennifer Ryal. "S1538 The Unseen Complication of Binge Drinking: Purtscher-Like Retinopathy in Acute Pancreatitis." American Journal of Gastroenterology 115, no. 1 (October 2020): S778—S779. http://dx.doi.org/10.14309/01.ajg.0000708200.13459.c6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Bell, Richard L., Zachary A. Rodd, Eric A. Engleman, Jamie E. Toalston, and William J. McBride. "Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: Modeling adolescent and adult binge-like drinking." Alcohol 48, no. 3 (May 2014): 225–34. http://dx.doi.org/10.1016/j.alcohol.2013.10.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Metso, Leena, and Jussi Simpura. "The finnish drinking habits during the 1990s." Nordic Studies on Alcohol and Drugs 14, no. 3 (June 1997): 154–66. http://dx.doi.org/10.1177/145507259701400301.

Full text

Abstract:

Three nationwide surveys from the years 1992, 1993, and 1996 were used to study whether basic features of Finnish drinking habits changed in the 1990s. Two factors that might have produced changes are the deep economic depression since 1991 and Finland's EU membership since 1995. The effects of the depression were visible in a decline in overall alcohol consumption after 1991, which recovered to the earlier level by 1996. The effects of EU membership involved, among many other things, certain administrative structures of the Finnish alcohol monopoly system. However, basic features of drinking patterns, like abstinence, drinking frequency, frequency of binge drinking, and the distribution of alcohol consumption, have remained untouched by those external changes. This can be taken as further evidence that drinking patterns typically change very slowly.

APA, Harvard, Vancouver, ISO, and other styles

33

Nascimento, Chirlene Pinheiro, Diandra Araújo Luz, Carla Cristiane Soares da Silva, Cláudia Marques Rosa Malcher, Luanna Melo Pereira Fernandes, Herta Stutz Dalla Santa, Antônio Rafael Quadros Gomes, et al. "Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking." Oxidative Medicine and Cellular Longevity 2020 (July 31, 2020): 1–12. http://dx.doi.org/10.1155/2020/2497845.

Full text

Abstract:

Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period. In this study, we investigated whether the Aqueous Extract of G. lucidum (AEGl) reduces the behavioral disorders induced by alcohol. Male (n=30) and female Wistar rats (n=40), seventy-two days old, were used for behavioral/biochemical and oral toxicity test, respectively. Animals were exposed to 5 binges (beginning at 35 days old) of ethanol (3 g/kg/day) or distilled water. Twenty-four hours after the last binge administration, animals received AEGl (100 mg/kg/day) or distilled water for three consecutive days. After treatment protocol, open field, elevated plus maze, forced swim, and step-down inhibitory avoidance tests were performed. Oxidative stress parameters were measured to evaluate the REDOX balance. Our results demonstrated that AEGl elicited the recovery of spontaneous horizontal exploration capacity, anxiogenic- and depressive-profile, as well as short-term memory damage induced by binge-ethanol exposure. The behavioral effects of the extract were associated to the reequilibrium of the animals’ REDOX balance. Thus, AEGl, a medicinal mushroom, ameliorates behavioral alteration on a model of motor, cognitive and psychiatric-like disorders induced by binge drinking paradigm and emerges as a useful tool as a food supplement in the management of disorders of alcoholic origin.

APA, Harvard, Vancouver, ISO, and other styles

34

Bitew, Mezinew Sintayehu, Maereg Fekade Zewde, Muluken Wubetu, and Addisu Alehegn Alemu. "Consumption of alcohol and binge drinking among pregnant women in Addis Ababa, Ethiopia: Prevalence and determinant factors." PLOS ONE 15, no. 12 (December 22, 2020): e0243784. http://dx.doi.org/10.1371/journal.pone.0243784.

Full text

Abstract:

Introduction People in Ethiopia, including pregnant women, highly consume both home-made and manufactured alcohol beverages due to lack of awareness about the harmful effect of risky alcohol use, and cultural acceptance of alcohol consumption. Alcohol consumption and other hazardous patterns of use like binge drinking have tremendous adverse effects on fetus and mothers. Therefore, this study aimed to assess the magnitude of alcohol consumption, binge drinking and its determinants among pregnant women residing in Kolfe sub-city, Addis Ababa, Ethiopia. Methods Institutional based cross-sectional study was conducted among a total of 367 pregnant women. The participants were selected using a systematic random sampling method. Data were collected through a structured questionnaire. A binary logistic regression was conducted using SPSS version 20 software to identify determinants of alcohol consumption and binge drinking. A p-value < 0.05 was used to declare a statistical significance in multiple logistic regression. The results were described using adjusted odds ratio with a 95% confidence interval. Results This study revealed that the prevalence of alcohol consumption, binge drinking, and weekly alcohol consumption of four or more units among pregnant women was 39.78%, 3.54% and 4.9%, respectively. Not having formal education [AOR 95% CI = 8.47 (2.42, 29.62), having primary education [AOR 95% CI = 4.26 (1.23, 14.74), being a housewife [AOR 95% CI = 4.18 (2.13, 8.22), having an unplanned pregnancy [AOR 95% CI = 2.47(1.33, 4.60), having a history of abortion [AOR 95% CI = 3.33 (1.33, 6.05)], not having awareness about the harmful effect of alcohol consumption [AOR 95% CI = 4.66 (2.53, 8.61)], and not having family social support [AOR 95% CI = 2(1.14,3.53) were determinants of alcohol consumption among pregnant women. Conclusions This study found a high level of alcohol consumption among pregnant women. Interventions to create awareness on the harmful effects of alcohol are needed. Moreover, strengthening social support during pregnancy and family planning services to reduce unplanned pregnancy and abortion should be considered.

APA, Harvard, Vancouver, ISO, and other styles

35

SALANŢĂ, Liana Claudia, Maria TOFANĂ, Carmen R. POP, Anamaria POP, Teodora COLDEA, and Mihaela MIHAI. "Risk Factors Associated with Alcohol Consumption Among Romanian University Students- Preliminary Research." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Food Science and Technology 75, no. 1 (May 17, 2018): 86. http://dx.doi.org/10.15835/buasvmcn-fst:0025.

Full text

Abstract:

Young people’s consumption of alcohol is an ongoing problem. Many young adults binge-drink alcohol excessively, with serious negative consequences thereafter. This preliminary research assessed risk factors associated with alcohol consumption, drinking problems and related consequences among university students. The study was carried out on a total of 1056 students from UASVM Cluj-Napoca, Romania. University students claimed altered states of health after drinking episodes: vomiting, abdominal pain, headache, dizziness (43.1%), forgetfulness after drinking (3.1%). Furthermore, students who drank over the limit reported physical and violence-related problems (2.7%) and were more likely to develop risky behaviors, like driving under the influence of alcohol (13.9%) or car accidents (0.2%). The participants in the study were not heavy social drinkers, 50.9% of the respondents reported no consequences after drinking alcohol.

APA, Harvard, Vancouver, ISO, and other styles

36

Evans, Ophelia, Olga Rodríguez‐Borillo, Laura Font, Paul J. Currie, and Raúl Pastor. "Alcohol Binge Drinking and Anxiety‐Like Behavior in Socialized Versus Isolated C57BL/6J Mice." Alcoholism: Clinical and Experimental Research 44, no. 1 (December 3, 2019): 244–54. http://dx.doi.org/10.1111/acer.14236.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Gregersen, Laura Stonor, Julie Werenberg Dreier, and Katrine Strandberg-Larsen. "Binge drinking during pregnancy and psychosis-like experiences in the child at age 11." European Child & Adolescent Psychiatry 29, no. 3 (July 20, 2019): 385–93. http://dx.doi.org/10.1007/s00787-019-01374-w.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Sprow, Gretchen M., Jennifer A. Rinker, Emily G. Lowery-Gointa, Angela M. Sparrow, Montserrat Navarro, and Todd E. Thiele. "Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice." Addiction Biology 21, no. 4 (May 15, 2015): 835–46. http://dx.doi.org/10.1111/adb.12264.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Carvajal, Francisca, Manuel Alcaraz-Iborra, Jose Manuel Lerma-Cabrera, Luis Miguel Valor, Leticia de la Fuente, Maria del Carmen Sanchez-Amate, and Inmaculada Cubero. "Orexin receptor 1 signaling contributes to ethanol binge-like drinking: Pharmacological and molecular evidence." Behavioural Brain Research 287 (July 2015): 230–37. http://dx.doi.org/10.1016/j.bbr.2015.03.046.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Marshall, S. A., S. E. McIntosh, L. E. Dorn, E. Greengrove, R. D. Thomas, D. T. Lysle, and T. E. Thiele. "Changes in cytokine and glial responses induced by binge-like drinking under nondependent conditions." Alcohol 66 (February 2018): 91–92. http://dx.doi.org/10.1016/j.alcohol.2017.11.019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Herman, Melissa A., Harpreet Sidhu, David G. Stouffer, Max Kreifeldt, David Le, Chelsea Cates-Gatto, Michaelanne B. Munoz, et al. "GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol." Proceedings of the National Academy of Sciences 112, no. 22 (May 11, 2015): 7091–96. http://dx.doi.org/10.1073/pnas.1416146112.

Full text

Abstract:

G protein-gated inwardly rectifying potassium (GIRK) channels are critical regulators of neuronal excitability and can be directly activated by ethanol. Constitutive deletion of the GIRK3 subunit has minimal phenotypic consequences, except in response to drugs of abuse. Here we investigated how the GIRK3 subunit contributes to the cellular and behavioral effects of ethanol, as well as to voluntary ethanol consumption. We found that constitutive deletion of GIRK3 in knockout (KO) mice selectively increased ethanol binge-like drinking, without affecting ethanol metabolism, sensitivity to ethanol intoxication, or continuous-access drinking. Virally mediated expression of GIRK3 in the ventral tegmental area (VTA) reversed the phenotype of GIRK3 KO mice and further decreased the intake of their wild-type counterparts. In addition, GIRK3 KO mice showed a blunted response of the mesolimbic dopaminergic (DA) pathway to ethanol, as assessed by ethanol-induced excitation of VTA neurons and DA release in the nucleus accumbens. These findings support the notion that the subunit composition of VTA GIRK channels is a critical determinant of DA neuron sensitivity to drugs of abuse. Furthermore, our study reveals the behavioral impact of this cellular effect, whereby the level of GIRK3 expression in the VTA tunes ethanol intake under binge-type conditions: the more GIRK3, the less ethanol drinking.

APA, Harvard, Vancouver, ISO, and other styles

42

Cáceres-Ayala, Constanza, Rodrigo G. Mira, María José Acuña, Enrique Brandan, Waldo Cerpa, and Daniela L. Rebolledo. "Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats." International Journal of Molecular Sciences 24, no. 2 (January 14, 2023): 1655. http://dx.doi.org/10.3390/ijms24021655.

Full text

Abstract:

Binge Drinking (BD) corresponds to episodes of ingestion of large amounts of ethanol in a short time, typically ≤2 h. BD occurs across all populations, but young and sports-related people are especially vulnerable. However, the short- and long-term effects of episodic BD on skeletal muscle function have been poorly explored. Young rats were randomized into two groups: control and episodic Binge-Like ethanol protocol (BEP) (ethanol 3 g/kg IP, 4 episodes of 2-days ON-2-days OFF paradigm). Muscle function was evaluated two weeks after the last BEP episode. We found that rats exposed to BEP presented decreased muscle strength and increased fatigability, compared with control animals. Furthermore, we observed that skeletal muscle from rats exposed to BEP presented muscle atrophy, evidenced by reduced fiber size and increased expression of atrophic genes. We also observed that BEP induced fibrotic and inflammation markers, accompanied by mislocalization of nNOSµ and high levels of protein nitration. Our findings suggest that episodic binge-like ethanol exposure alters contractile capacity and increases fatigue by mechanisms involving atrophy, fibrosis, and inflammation, which remain for at least two weeks after ethanol clearance. These pathological features are common to several neuromuscular diseases and might affect muscle performance and health in the long term.

APA, Harvard, Vancouver, ISO, and other styles

43

Navarro, M., I. Cubero, L. Ko, and T. E. Thiele. "Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice." Genes, Brain and Behavior 8, no. 4 (June 2009): 450–58. http://dx.doi.org/10.1111/j.1601-183x.2009.00493.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Morales, Ileana, Olga Rodríguez-Borillo, Laura Font, and Raúl Pastor. "Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice." Behavioural Pharmacology 31, no. 2&3 (April 2020): 256–71. http://dx.doi.org/10.1097/fbp.0000000000000553.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Hargreaves, Garth A., Lauren Monds, Nathan Gunasekaran, Bronwyn Dawson, and Iain S. McGregor. "Intermittent access to beer promotes binge-like drinking in adolescent but not adult Wistar rats." Alcohol 43, no. 4 (June 2009): 305–14. http://dx.doi.org/10.1016/j.alcohol.2009.02.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Ozburn, Angela R., Amanda M. Barkley-Levenson, Pamela Metten, and John C. Crabbe. "Using High Drinking in the Dark (HDID) mice as an animal model to identify drugs to reduce alcohol binge-like drinking." Alcohol 60 (May 2017): 227. http://dx.doi.org/10.1016/j.alcohol.2017.02.284.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Liu, Dan, Haohao Hu, Yuchuan Hong, Qian Xiao, and Jie Tu. "Sugar Beverage Habitation Relieves Chronic Stress-Induced Anxiety-like Behavior but Elicits Compulsive Eating Phenotype via vLSGAD2 Neurons." International Journal of Molecular Sciences 24, no. 1 (December 30, 2022): 661. http://dx.doi.org/10.3390/ijms24010661.

Full text

Abstract:

Chronically stressed individuals are reported to overconsume tasty, palatable foods like sucrose to blunt the psychological and physiological impacts of stress. Negative consequences of high-sugar intake on feeding behavior include increased metabolic disease burdens like obesity. However, the neural basis underlying long-term high-sugar intake-induced overeating during stress is not fully understood. To investigate this question, we used the two-bottle sucrose choice paradigm in mice exposed to chronic unpredictable mild stressors (CUMS) that mimic those of daily life stressors. After 21 days of CUMS paralleled by consecutive sucrose drinking, we explored anxiety-like behavior using the elevated plus maze and open field tests. The normal water-drinking stressed mice displayed more anxiety than the sucrose-drinking stressed mice. Although sucrose-drinking displayed anxiolytic effects, the sucrose-drinking mice exhibited binge eating (chow) and a compulsive eating phenotype. The sucrose-drinking mice also showed a significant body-weight gain compared to the water-drinking control mice during stress. We further found that c-Fos expression was significantly increased in the ventral part of the lateral septum (vLS) of the sucrose-treated stressed mice after compulsive eating. Pharmacogenetic activation of the vLS glutamate decarboxylase 2(GAD2) neurons maintained plain chow intake but induced a compulsive eating phenotype in the naïve GAD2-Cre mice when mice feeding was challenged by flash stimulus, mimicking the negative consequences of excessive sucrose drinking during chronic stress. Further, pharmacogenetic activation of the vLSGAD2 neurons aggravated anxiety of the stressed GAD2-Cre mice but did not alter the basal anxiety level of the naïve ones. These findings indicate the GABAergic neurons within the vLS may be a potential intervention target for anxiety comorbid eating disorders during stress.

APA, Harvard, Vancouver, ISO, and other styles

48

Vilpoux, Catherine, Gregory Fouquet, Chloe Deschamps, Elise Lefebvre, Philippe Gosset, Johann Antol, Luciane Zabijak, Ingrid Marcq, Mickael Naassila, and Olivier Pierrefiche. "Astrogliosis and compensatory neurogenesis after the first ethanol binge drinking‐like exposure in the adolescent rat." Alcoholism: Clinical and Experimental Research 46, no. 2 (December 21, 2021): 207–20. http://dx.doi.org/10.1111/acer.14757.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

King, Courtney E., William C. Griffin, Marcelo F. Lopez, and Howard C. Becker. "Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors." Neuropsychopharmacology 46, no. 11 (June 14, 2021): 1950–57. http://dx.doi.org/10.1038/s41386-021-01046-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Lacaille, Hélène, Dominique Duterte-Boucher, Donovan Liot, Hubert Vaudry, Mickael Naassila, and David Vaudry. "Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice." Journal of Neurochemistry 132, no. 6 (February 12, 2015): 629–41. http://dx.doi.org/10.1111/jnc.13020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!