Academic literature on the topic 'Binge-like drinking'
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Journal articles on the topic "Binge-like drinking"
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Pozhidayeva, Dar’ya Y., Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, and Angela R. Ozburn. "Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes." Brain Sciences 10, no. 2 (February 18, 2020): 109. http://dx.doi.org/10.3390/brainsci10020109.
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Binge drinking is a dangerous pattern of behavior. We tested whether chronically manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide (CNO) and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)) could produce lasting effects on ethanol binge-like drinking in mice selectively bred to drink to intoxication. We found chronically increasing NAc activity (4 weeks, via CNO and the excitatory DREADD, hM3Dq) decreased binge-like drinking, but did not observe CNO-induced changes in drinking with the inhibitory DREADD, hM4Di. The CNO/hM3Dq-induced reduction in ethanol drinking persisted for at least one week, suggesting adaptive neuroplasticity via transcriptional and epigenetic mechanisms. Therefore, we defined this plasticity at the morphological and transcriptomic levels. We found that chronic binge drinking (6 weeks) altered neuronal morphology in the NAc, an effect that was ameliorated with CNO/hM3Dq. Moreover, we detected significant changes in expression of several plasticity-related genes with binge drinking that were ameliorated with CNO treatment (e.g., Hdac4). Lastly, we found that LMK235, an HDAC4/5 inhibitor, reduced binge-like drinking. Thus, we were able to target specific molecular pathways using pharmacology to mimic the behavioral effects of DREADDs.
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YOUNG, AMY M., MICHELE MORALES, SEAN ESTEBAN McCABE, CAROL J. BOYD, and HANNAH D'ARCY. "Drinking Like a Guy: Frequent Binge Drinking Among Undergraduate Women." Substance Use & Misuse 40, no. 2 (January 2005): 241–67. http://dx.doi.org/10.1081/ja-200048464.
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Czapla, Marta, Joe J. Simon, Hans-Christoph Friederich, Sabine C. Herpertz, Peter Zimmermann, and Sabine Loeber. "Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?" European Addiction Research 21, no. 2 (November 22, 2014): 105–13. http://dx.doi.org/10.1159/000367939.
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Background/Aims: Little is known about the association of binge drinking with impulsivity related to trait- or state-like aspects of behavior. The aim of the present study was therefore to investigate whether binge drinkers show an impairment of inhibitory control in comparison to non-binge drinkers when confronted with alcohol-associated or control stimuli, and whether this is reflected in self-reported impulsivity. Methods: A go/no-go task with pictures of alcoholic and nonalcoholic beverages as well as control stimuli was administered to binge drinkers and a gender-matched group of non-binge drinkers. All participants also completed the Barratt Impulsiveness Scale (BIS-11). Results: We found an alcohol-specific impairment of response inhibition for binge drinkers only, while the groups did not differ with regard to overall response inhibition to the experimental stimuli or self-reported impulsiveness (BIS-11). In addition, the number of commission errors in response to alcohol-associated stimuli was the only significant predictor of binge drinking. Conclusion: The findings of the present study suggest that when young adults have established binge drinking as a common drinking pattern, impairment of inhibition in response to alcoholic stimuli is the only significant predictor of binge drinking, but not general impulsive behavior. i 2014 S. Karger AG, Basel
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Gutema, Hordofa, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Tebkew Shibabaw, and Tolera Disasa. "Predicting binge drinking among university students: Application of integrated behavioral model." PLOS ONE 16, no. 7 (July 9, 2021): e0254185. http://dx.doi.org/10.1371/journal.pone.0254185.
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Background Binge drinking is a pattern of harmful use of alcohol and it is defined as four drinks for women and five drinks for men in about 2 hours. This behavior causes public health problems like damaging different body organs. Objective To assess binge drinking and associated factors among Bahir Dar University students in Northwest Ethiopia. Method A cross sectional study was conducted in November 2017. Systematic sampling technique was used to select 422 participants. Structured questionnaire was used to collect data. Linear and Logistic regression models were used to predict the role of explanatory variables on behavioral intention and binge drinking, respectively. Independent variables with a p-value of <0.05 at 95% confidence interval were considered as statistically significant in the final model. Result A total of 413 students participated in this study and 33.4%(95% CI: 28.3–38.9) were engaged in binge drinking. Experiential attitude, instrumental attitude, and self-efficacy were found to be significant predictors of intention to binge drinking (p<0.05). Experiential attitude, environmental constraint, injunctive norm, and knowledge predictors were significantly associated with binge drinking (p<0.05). Conclusion Our study indicated that one-third of the students practiced binge drinking. This behavior was associated with experiential attitude, injunctive norm, environmental constraints, and knowledge factors. Additionally, experiential attitude, instrumental attitude, and self-efficacy constructs had explained behavioral intention. This implies focusing on the abovementioned determinant factors is imperative while designing intervention strategy.
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Grigsby, Kolter, Courtney Ledford, Tanvi Batish, Snigdha Kanadibhotla, Delaney Smith, Evan Firsick, Alexander Tran, et al. "Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression." International Journal of Molecular Sciences 23, no. 19 (September 21, 2022): 11084. http://dx.doi.org/10.3390/ijms231911084.
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Previous studies (1) support a role of circadian genes in regulating alcohol intake, and (2) reveal that harmful alcohol use alters circadian rhythms. However, there is minimal knowledge of the effects of chronic alcohol processes on rhythmic circadian gene expression across brain regions important for circadian biology and alcohol intake. Therefore, the present study sought to test the effects of chronic binge-like drinking on diurnal circadian gene expression patterns in the master circadian pacemaker (SCN), the ventral tegmental area (VTA), and the nucleus accumbens (NAc) in High Drinking in the Dark-1 (HDID-1) mice, a unique genetic risk model for drinking to intoxication. Consistent with earlier findings, we found that 8 weeks of binge-like drinking reduced the amplitude of several core circadian clock genes in the NAc and SCN, but not the VTA. To better inform the use of circadian-relevant pharmacotherapies in reducing harmful drinking and ameliorating alcohol’s effects on circadian gene expression, we tested whether the casein kinase-1 inhibitor, PF-67046, or the phosphodiesterase type-4 (an upstream regulator of circadian signalling) inhibitor, apremilast, would reduce binge-like intake and mitigate circadian gene suppression. PF-67046 did not reduce intake but did have circadian gene effects. In contrast, apremilast reduced drinking, but had no effect on circadian expression patterns.
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Nentwig, Todd B., Colleen E. McGonigle, Diane E. Wilson, Erin M. Rhinehart, and Judith E. Grisel. "Beta-endorphin modulates binge-like ethanol drinking in mice." Alcohol 60 (May 2017): 240. http://dx.doi.org/10.1016/j.alcohol.2017.02.342.
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Queiroz, Letícia Yoshitome, Igor Gonçalves de Oliveira, Sabrina de Carvalho Cartágenes, Luanna Melo Pereira Fernandes, Sávio Monteiro dos Santos, Wallax Augusto Silva Ferreira, Fernando Augusto Rodrigues Mello Junior, et al. "Repeated Cycles of Binge-Like Ethanol Exposure Induces Neurobehavioral Changes During Short- and Long-Term Withdrawal in Adolescent Female Rats." Oxidative Medicine and Cellular Longevity 2022 (October 25, 2022): 1–11. http://dx.doi.org/10.1155/2022/7207755.
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Alcohol consumption is spread worldwide and can lead to an abuse profile associated with severe health problems. Adolescents are more susceptible to addiction and usually consume ethanol in a binge drinking pattern. This form of consumption can lead to cognitive and emotional disorders, however scarce studies have focused on long-term hazardous effects following withdrawal periods after binge drinking in adolescents. Thus, the present study aims at investigating whether behavioral and cognitive changes persist until mid and late adulthood. Female Wistar rats (9-10 animals/group) received intragastric administration of four cycles of ethanol binge-like pattern (3.0 g/kg/day, 20% w/v; 3 days-on/4 days-off) from 35th to 58th days old, followed withdrawal checkpoints 1 day, 30 days, and 60 days. At each checkpoint period, behavioral tests of open field, object recognition test, elevated plus maze, and forced swimming test were performed, and blood and hippocampus were collected for oxidative biochemistry and brain-derived neurotrophic factor (BDNF) levels analysis, respectively. The results demonstrated that adolescent rats exposed to binge drinking displayed anxiogenic- and depressive-like phenotype in early and midadulthood, however, anxiety-like profile persisted until late adulthood. Similarly, short-term memory was impaired in all withdrawal periods analysed, including late adult life. These behavioral data were associated with oxidative damage in midadulthood but not BDNF alterations. Taken together, the present work highlights the long-lasting emotional and cognitive alterations induced by ethanol binge drinking during adolescence, even after a long period of abstinence, which might impact adult life.
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Likashi, Danny Vumbi, Ravi Paul, and Luty Jason. "The Proportion of Binge Drinking Among Female Social Drinkers of Kalingalinga in Lusaka, Zambia: A Pilot Study." Global Psychiatry 2, no. 1 (March 25, 2019): 43–50. http://dx.doi.org/10.2478/gp-2019-0005.
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AbstractObjectivesAlcohol is a psychoactive substance with dependence-producing properties. Alcohol’s harmful use causes large burden diseases like social and economic burden in societies. Binge drinking is one of the commonest forms of alcohol misuse and has been on an increase among many young women, who find alcohol a source of pleasure and enjoyment when they have timeout with friends and peers. Since binge drinking involves consumption of alcohol on an irregular basis, it may not be viewed as a hazardous form of alcohol use by many drinkers. The present study is aimed at estimating the proportion of female binge drinkers in the population of female social drinkers in Kalingalinga township of Lusaka, the capital city of Zambia. We hypothesised that the proportion of binge drinking in the population of female social drinkers is significantly high.MethodsThrough snowball sampling, 100 questionnaires (i.e., Alcohol Use Disorders Identification Test-AUDIT) were successfully distributed to and collected from the female social drinkers aged 20–39 years between August and September, 2016. A two-fold process was followed in identifying the binge drinkers; screening for hazardous alcohol drinkers by identifying those that scored 8 points or above in the first place, and thereafter, identifying binge drinking characteristics from the hazardous drinkers by following scores from the first three questions on the AUDIT.ResultsThe results reviewed that 54 of the 100 participants had some form of hazardous alcohol use and 30 of the 54 hazardous drinkers possessed some binge drinking characteristics. The proportion of female binge drinkers in a population of female alcohol drinkers was estimated to be 0.556 (56.6%), while in the general population, it was estimated to be 0.094. This implies that 9.4% of women aged 20–39 years of Kalingalinga in Lusaka engage in alcohol binge drinking, consuming on average 7–9 drinks on occasion almost on a weekly basis. Further, if 56% of all female alcohol drinkers aged 20–39 years seem to engage in some form of alcohol binge drinking, it means that that binge drinking is the highest form of alcohol misuse among these female drinkers.ConclusionThe results of the present study suggest that there is more alcohol binge drinking among the female social drinkers of Kalingalinga in Lusaka, with an estimated proportion of 0.556 (55.6%) among the female alcohol drinkers and 0.094 (9.4%) in the general population of females aged between 20–39 years. The implication is that alcohol binge drinking seems to be the highest form of alcohol misuse among female drinkers in Kalingalinga.
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Radke, Anna K., Elizabeth A. Sneddon, Raizel M. Frasier, and Frederic W. Hopf. "Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking." International Journal of Molecular Sciences 22, no. 7 (April 6, 2021): 3788. http://dx.doi.org/10.3390/ijms22073788.
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Alcohol use disorder remains a substantial social, health, and economic problem and problem drinking levels in women have been increasing in recent years. Understanding whether and how the underlying mechanisms that drive drinking vary by sex is critical and could provide novel, more targeted therapeutic treatments. Here, we examine recent results from our laboratories and others which we believe provide useful insights into similarities and differences in alcohol drinking patterns across the sexes. Findings for binge intake and aversion-resistant, compulsion-like alcohol drinking are considered, since both are likely significant contributors to alcohol problems in humans. We also describe studies regarding mechanisms that may underlie sex differences in maladaptive alcohol drinking, with some focus on the importance of nucleus accumbens (NAcb) core and shell regions, several receptor types (dopamine, orexin, AMPA-type glutamate), and possible contributions of sex hormones. Finally, we discuss how stressors such as early life stress and anxiety-like states may interact with sex differences to contribute to alcohol drinking. Together, these findings underscore the importance and critical relevance of studying female and male mechanisms for alcohol and co-morbid conditions to gain a true and clinically useful understanding of addiction and neuropsychiatric mechanisms and treatment.
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Grigsby, Kolter B., Antonia M. Savarese, Pamela Metten, Barbara J. Mason, Yuri A. Blednov, John C. Crabbe, and Angela R. Ozburn. "Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice." Neuroscience Insights 15 (January 2020): 263310552097541. http://dx.doi.org/10.1177/2633105520975412.
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High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, 0.5, 1, and 2 mg/kg), sirolimus (0, 5, 10, and 20 mg/kg), palmitoylethanolamide (PEA; 0, 75, 150, and 225 mg/kg), and secukinumab (0, 5, 20, and 60 mg/kg) on binge-like ethanol intake (2-day, “Drinking in the Dark” [DID]) and blood alcohol levels (BALs) in HDID-1 mice. Tacrolimus reduced ethanol intake and BALs. Tacrolimus had no effect on water intake, but reduced saccharin intake. There was no effect of sirolimus, PEA, or secukinumab on ethanol intake or BALs. These results compare and contrast with previous work addressing these compounds or their targeted mechanisms of action on ethanol drinking, highlighting the importance of screening a wide range of models and genotypes to inform the role of neuroimmune signaling in AUDs.
Dissertations / Theses on the topic "Binge-like drinking"
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Linsenbardt, David Nathaniel. "Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice involvement of the posterior ventral tegmental area /." Diss., Online access via UMI:, 2008.
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Ali, Syed Aoun. "Sugar consumption and expression of neuronal nicotinic receptors in the Nucleus Accumbens." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/208972/1/Syed%20Aoun_Ali_Thesis.pdf.
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High sugar and fat intake lead to a higher probability of developing obesity, dementia, and cardiovascular diseases. It causes significant changes in the brain such as the expression of neuronal nicotinic acetylcholine receptors (nAChRs) involved in the consumption of nicotine and alcohol. Long-term consumption of sugar effect on nAChRs in the Nucleus Accumbens (NAc) was examined. Varenicline, an FDA approved smoking cessation drug, significantly reduced sugar intake in mice when it was administered to the NAc. Targeting nAChRs as a potential pharmacotherapeutic strategy to reduce sugar intake, may open a new avenue and treatment strategy to flatten the obesity epidemic.
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Kasten, Chelsea Rae. "Intra-nucleus accumbens shell injections of R(+)- and S(-)- baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice." Thesis, Behavioural Brain Research (Elsevier), 2014. http://hdl.handle.net/1805/6453.
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Indiana University-Purdue University Indianapolis (IUPUI)It has been proposed that the GABAB receptor subtype plays a role in alcoholism and alcohol use disorders (AUDs) (Cousins et al., 2002; Agabio et al., 2012). Specifically, the GABAB agonist baclofen has been looked at extensively in clinical and pre-clinical studies. In various animal models of chronic and intermittent consumption, baclofen has been shown to both increase (Petry, 1997; Smith et al., 1999; Czachowski et al., 2006; Moore et al., 2007) and decrease (Colombo et al., 2000; 2002; 2005; Stromberg, 2004; Moore et al., 2009) drinking. A critical issue in determining pharmacological effects of a drug is using the appropriate animal model. The drinking-in-the-dark (DID) model, developed by Rhodes et al. (2005, 2007), produces high levels of drinking in a binge-like paradigm and has been used to assess many pharmacological targets (e.g. Kamdar et al., 2007; Gupta et al., 2008; Moore et al., 2007; 2009). While DID produces high-levels of binge drinking, it is unclear what areas of the brain are involved in this behavior. A direct way to target areas that are believed to be involved in the circuitry of particular behaviors is through microinjection of drugs (Kiianmaa et al., 2003). Of particular recent interest involving motivated behaviors and addiction is the nucleus accumbens (Acb) (Everitt & Robbins, 2005); specifically the accumbens shell (AcbSh) (e.g. Rewal et al., 2009, 2012; Nie et al., 2011; Leriche et al., 2008). The current study aimed to investigate the role of GABAB receptors in the AcbSh by examining the ability of two different enantiomers of baclofen to alter ethanol and saccharin intake in male C57BL/6J (B6) mice. B6 mice underwent bilateral cannulation surgery targeting the AcbSh. After 48 hours of recovery time, animals began a five day Drinking-in-the-Dark (DID) procedure where they received 20% ethanol or 0.2% saccharin for two hours, three hours into the dark cycle, each day. Throughout the five drinking sessions, animals were kept in home-cage locomotor activity chambers to monitor activity throughout the drinking cycle. Day 4 drinking was immediately preceded by a mock microinjection, whereas Day 5 drinking was immediately preceded by a drug microinjection. Microinjection of one of five doses of baclofen was given in ng/side dissolved in 200 µl of aCSF (aCSF alone, 0.02 R(+)-, 0.04 R(+)-, 0.08 S(-)-, or 0,16 S(-)-). Intake was recorded every twenty minutes on Days 4 and 5. Retro-orbital sinus blood samples were taken from ethanol animals immediately following the Day 5 drinking period to determine blood ethanol concentrations (BECs). A one-way ANOVA on total Day 4 ethanol consumption revealed no baseline differences between dose groups. A one-way ANOVA on total Day 5 ethanol consumption revealed that the 0.04 R(+)- baclofen dose reduced total drinking, but the 0.16 S(-)- baclofen dose increased total drinking (p’s<0.05). This pattern was reflected in the BECs; 0.04 R(+)- baclofen reduced BECs, whereas 0.16 S(-)- baclofen increased BECs (p’s<0.05). These results were also time-dependent, with R(+)-baclofen reducing drinking in the first 20 minutes of the session and S(-)- increasing drinking in the last 40 minutes of the session. There were no effects on saccharin intake. An issue with the locomotor activity boxes led to unreliable locomotor activity counts. However, because there were no drug effects on saccharin consumption, it was concluded that locomotor effects did not contribute to the decreases or increases in ethanol consumption. These results further implicate the role of GABAB receptors in modulating ethanol intake. The bidirectional effects shown highlight the importance of considering enantioselective drug effects when interpreting data. Finally, these results also support previous conclusions that the AcbSh plays an important role in modulating use of drugs of abuse, but not other reinforcers.
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Bauer, Meredith R. "A Single Alcohol Pre-exposure Alters Dorsolateral Striatal AMPA Receptor Dependent Binge and Compulsive-like Drinking." Thesis, 2020. http://hdl.handle.net/1805/24766.
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Indiana University-Purdue University Indianapolis (IUPUI)Background Compulsive alcohol drinking is a defining characteristic of alcohol use disorder and the dorsolateral striatum (DLS) is implicated in regulating this inflexible behavior. AMPA receptors have been implicated in both goal-directed (dorsomedial striatal dependent) and DLS dependent inflexible behaviors with antagonism in the DLS and general DLS inhibition altering inflexible behavior including habit and compulsion. Discrepancies exist in the preclinical models used to investigate compulsive-like alcohol. The purpose of these experiments was to establish a robust model of compulsive-like quinine adulterated alcohol (QuA) drinking in C57BL/6J male and female mice, assess associated AMPA receptor protein expression in the dorsal striatum, and to antagonize DLS AMPA receptors during compulsive-like QuA drinking using a model of binge-like alcohol drinking, Drinking-in-the-Dark (DID). Methods In aim 1, C57BL/6J mice were allowed free access to 20% (v/v) alcohol (alcohol history), or water (water history) for two hours each day beginning three hours into the dark cycle for 23 days. On days 15 and 22 mice were given QuA to test for compulsive-like QuA drinking. 24-hours following the last DID session brain slices were taking for DLS and DMS AMPA receptor western blot. In aim 2, C57BL/6J mice were given a total of 21 days alcohol history, to establish a compulsive-like phenotype, or water history, prior to infusion. On days 22 and 24 mice were given a bilateral infusion of one of three concentrations of NBQX, an AMPA receptor antagonist, into the DLS, immediately prior to DID where the DID solution was either alcohol or QuA. Results We found that three weeks, not two, is sufficient to produce robust compulsive-like QuA drinking in C57BL/6J mice. We failed to replicate our compulsive-like DID model in aim 2 and found that infusion of NBQX reduced 2-hour alcohol drinking and reduced 2-hour QuA drinking when QuA was the second solution presented on infusion days in male water history mice only. We also found that NBQX reduced 20-minute front-loading in female alcohol history mice on alcohol intake and trended toward QuA intake. Overall locomotor activity was affected by drug infusions. Conclusions Together, these data suggest that compulsive-like alcohol drinking can be achieved following three-weeks DID and DLS infusion of NBQX reduces both alcohol and QuA drinking in a sex and drinking history dependent way, and these effects may be reliant on an initial single QuA or alcohol exposure.
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Ângelo, Alexandra Antunes. "Study of neuroinflammation markers in the hippocampus of adolescent rats after binge-like ethanol exposure." Master's thesis, 2017. http://hdl.handle.net/10451/35902.
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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2017O início do consumo de álcool ocorre tipicamente durante a adolescência e os modos de consumo produzem efeitos visíveis a nível social e de saúde. A adolescência é um período de vida durante o qual ocorrem importantes processos do desenvolvimento cerebral, tendo sido previamente demonstrado que o cérebro adolescente é mais susceptível ao comprometimento da memória e danos cerebrais induzidos pelo etanol, pelo que o consumo excessivo de álcool pode gerar níveis neurotóxicos de intoxicação e ao desenvolvimento de efeitos profundos no sistema nervoso central. Estudos previamente realizados no laboratório GRAP demonstraram que uma exposição ao álcool do tipo binge-drinking através da administração de duas injecções consecutivas de etanol (3g/kg i.p.) em ratos foi suficiente para originar a abolição da plasticidade sináptica na região CA1 do hipocampo, bem como perdas nas habilidades de aprendizagem. Dada a relação recentemente descoberta entre a plasticidade sináptica e neuroinflamação, pretende-se agora investigar se este protocolo de exposição do tipo binge-drinking será capaz de provocar eventos neuroinflamatórios nas subregiões CA1 e Dentate Gyrus do hipocampo, utilizando dois marcadores de neuroinflamação, HMGB1 (High-mobility group box 1 protein) e TLR4 (Toll-like receptor). Os resultados do protocolo de imunohistoquímica realizado para HMGB1 revelaram que não existe diferenças estatisticamente significativas da expressão de HMGB1 entre o grupo de ratos submetidos à exposição do tipo binge-drinking e o grupo de controlo, o que sugere que a exposição excessiva ao etanol não altera a expressão de HMGB1, nem induz a ocorrência de fenómenos inflamatórios nas células neuronais, em nenhuma das subregiões do hipocampo em estudo. O estudo de imunofluorescência realizado revelou a ocorrência de um aumento da expressão de TLR4 nas duas subregiões do hipocampo em estudo dos ratos sujeitos à administração de álcool. Estes resultados sugerem que este protocolo do tipo binge-drinking parece ser suficiente para induzir fenómenos de neuroinflamação no hipocampo dos ratos.
The initiation of alcohol consumption typically occurs during adolescence and the patterns of drinking have an effect on health and social outcomes. The adolescence is a period of life, during which strong processes of brain development take place, having been previously demonstrated that adolescent brain is more susceptible to ethanol-induced memory impairment or brain damage, whereby excessive alcohol consumption may drive to neurotoxic levels of intoxication and to the development of profound effects on the central nervous system. Previous studies performed in GRAP laboratory demonstrated that binge-like ethanol exposure with two close injections of ethanol (3g/kg i.p.) in rat was enough to produce synaptic plasticity abolition in the CA1 of hippocampus, together with losses in learning abilities. Given the recently discovered relation between synaptic plasticity and neuroinflammation, we intended in this work to investigate whether this binge-like exposure protocol would be able to produce neuroinflammatory events in the CA1 field and Dentate Gyrus of the hippocampus, using two neuroinflammation markers, HMGB1 (High-mobility group box 1 protein) and TLR4 (Toll-like receptor). The results of the immunohistochemistry experiment performed for HMGB1 revealed that there are no statistically significant differences between the HMGB1 expression in group of rats exposed to the binge-drinking and the control group, which suggest that the binge-like ethanol exposure doesn't alter the HMGB1 expression and it doesn’t induce inflammatory phenomena in neurons, neither in CA1 nor Dentate Gyrus. The immunofluorescent study performed revealed an increase of TLR4 expression in both hippocampus subregions of binged rats, which suggests that this binge-like ethanol exposure protocol seems to be sufficient to induce neuroinflammation in the hippocampus of rats.
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Melón, Laverne C. "Does binge drinking induce PMDD-like dysfunction for female C57BL/6J mice? : implications for sex differences in addiction vulnerability." Thesis, 2014. http://hdl.handle.net/1805/6019.
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Indiana University-Purdue University Indianapolis (IUPUI)It has traditionally been posited that women show a "telescoped" development of alcohol use disorders (Kuhn, 2011). In particular, a number of clinical studies support striking sex differences in the progression from initial use of alcohol to dependence on the compound; with women showing a faster progression through landmark events associated with the development of alcohol addiction (Randall et al., 1999). However, recent studies have challenged this tenet (Keyes et al., 2010). The work presented herein was designed to determine whether females are indeed more vulnerable to the development of behavioral maladaptations following binge drinking and whether sex differences in GABA(A) receptor regulation might underlie this vulnerability. Using a mouse model of binge drinking this dissertation established that, compared to males, females escalate their binge drinking at a faster rate and maintain altered responsivity to the locomotor effects of alcohol after extended abstinence from binge drinking. Female mice also displayed significant increases in ethanol preference and intake in a continuous, two-bottle choice protocol following a shorter history of binge drinking than males. The final goal was to determine if binge drinking results in unique patterns of anxiety- or depressive-like symptoms in males and females and whether these behaviors would be associated with the dimorphic regulation of GABAA receptor subunits across the prefrontal cortex and hippocampus. Male binge drinkers displayed anxiety-like behavior during early withdrawal that dissipated after 2 weeks of abstinence. There were no significant changes in the expression of delta or gamma2 GABAA receptor subunit mRNA at this time point in the regions analyzed. Females also showed temporary anxiety-like behavior during early withdrawal from binge drinking. Additionally, females displayed significant depressive-like behavior after 2 weeks of abstinence from binge drinking. In particular, diestrus-phase females displayed significantly greater immobility in the forced-swim test after ethanol exposure and no longer maintained the reduced swim-time behavior associated with this phase of the cycle at baseline (when compared to the estrus-phase). qPCR analysis of hippocampal tissues from diestrus females supported a significant reduction in expression of gamma2 GABA(A) subunit mRNA after binge drinking. This effect was not noted for RNA isolated from hippocampal tissues taken during the estrus phase of bingers. These final data suggest possible interaction of estrous-cycle and binge drinking history that may result in the unique expression of deficits following binge drinking for females. Taken together, this work supports sex and estrous dependent effects of binge drinking on behavior and gene regulation.
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Fritz, Brandon Michael. "Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice." Thesis, 2013. http://hdl.handle.net/1805/3694.
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Indiana University-Purdue University Indianapolis (IUPUI)Extrasynaptic GABAA receptors, often identified as those containing both α4 and δ subunits, appear to be a target for the actions of alcohol (ethanol) at relatively low concentrations, perhaps suppressing the activity of GABAergic interneurons which regulate activity in the mesolimbocortical circuit. Pharmacological studies in rodents using the δ-subunit selective agonist Gaboxadol (THIP) have found both promotional and inhibitory effects on alcohol consumption. The goal of this project was to determine the role of extrasynaptic GABAA receptors located in the infralimbic cortex (ILC) in the binge-like alcohol intake of male C57BL/6J (B6) mice. The ILC is of interest due to its demonstrated involvement in stress reactivity and alcohol exposure has been shown to interfere with extinction learning; impairments of which may be related to inflexible behavior (i.e. problematic alcohol consumption). Adult male B6 mice were bilaterally implanted with stainless steel guide cannulae aimed at the ILC and were offered limited access to 20% ethanol or 5% sucrose for 6 days. On day 7, mice were bilaterally injected with 50 or 100 ng THIP (25 or 50 ng per side respectively) or saline vehicle into the ILC. It was found that the highest dose of THIP (100 ng/mouse) increased alcohol intake relative to vehicle controls, although control animals consumed relatively little ethanol following infusion. Furthermore, THIP had no effect on sucrose consumption (p > 0.05), suggesting that the effect of THIP was selective for ethanol consumption. Together, these findings suggest that the mice that consumed ethanol may have been particularly reactive to the microinfusion process relative to animals that consumed sucrose, perhaps because ethanol consumption was not as reinforcing as sucrose consumption. In addition, the observation that THIP effectively prevented the decrease in ethanol intake on day 7 induced by the microinjection process may be related to a role for the ILC in adaptive learning processes, which in turn, promote behavioral flexibility.
Book chapters on the topic "Binge-like drinking"
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Krieg, Dana B., and Anna K. Krause. "Drinking Like a Man: How Gender Norms Influence College Students’ Perceptions of Binge Drinkers." In Discourses on Gender and Sexual Inequality, 91–113. Emerald Publishing Limited, 2017. http://dx.doi.org/10.1108/s1529-212620170000023005.
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