Dissertations / Theses on the topic 'Binding phases'
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Whalley, Caroline. "Estimating binding strength and chemical phases of metals adsorbed to sediment components." Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259990.
Full textPanahi, Tayyebeh. "Glutamic Acid Resorcinarene-based Molecules and Their Application in Developing New Stationary Phases in Ion Chromatography." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6436.
Full textLi, Weijia, and n/a. "Development of New Binding Phases for Speciation Measurements of Trace Metals with the Diffusive Gradients in Thin Films Technique." Griffith University. School of Environmental and Applied Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040504.150905.
Full textWesterhult, David. "Weak Affinity Chromatography : Evaluation of Different Silica Supports for Protein Immobilizationand Effect of Mobile Phases Regarding Retentionand Non-specific Binding." Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-17968.
Full textDufresne, Alice. "Modélisation atomistique de la précipitation des hydrures de zirconium : Méthodologie de developpement d'un potentiel en liaisons fortes." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4096/document.
Full textThe zirconium-hydrogen system is of nuclear safety interest, as the hydride precipitation leads to the cladding embrittlement, which is made of zirconium-based alloys. The cladding is the first safety barrier confining the radioactive products: its integrity shall be kept during the entire fuel-assemblies life, in reactor, including accidental situation, and post-operation (transport and storage). Many uncertainties remain regarding the hydrides precipitation kinectics and the local stress impact on their precipitation. The atomic scale modeling of this system would bring clarifications on the relevant mechanisms. The usual atomistic modeling methods are based on thermostatistic approaches, whose precision and reliability depend on the interatomic potential used. However, there was no potential allowing a rigorous study of the Zr-H system. The present work has indeed addressed this issue: a new tight-binding potential for zirconium hydrides modeling is now available. Moreover, this thesis provides a detailed manual for deriving such potentials accounting for spd hybridization, and fitted here on DFT results. This guidebook has be written in light of modeling a pure transition metal followed by a metal-covalent coupling (metallic carbides, nitrides and silicides)
Palud, Amandine. "Liquid-liquid phase separation mediated by low complexity sequence domains promotes stress granule assembly and drives pathological fibrillization." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066560/document.
Full textStress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA. Functional impairment of stress granules has been implicated in amyotrophic lateral sclerosis, inclusion body myopathy, Paget’s disease of bone and frontotemporal dementia; these diseases are characterized by solid, fibrillar, cytoplasmic inclusions that are rich in RNA binding proteins (RBPs). Genetic evidence suggests a link between persistent stress granules and the accumulation of pathological inclusions. In this thesis manuscript, I demonstrate that the disease-related RBP hnRNPA1 undergoes liquid-liquid phase separation (LLPS) into protein-rich droplets mediated by a low complexity sequence domain (LCD). While the LCD of hnRNPA1 is sufficient to mediate LLPS, the folded RNA recognition motifs contribute to LLPS in the presence of RNA, potentially giving rise to several mechanisms for regulating assembly of stress granules. Importantly, while not required for LLPS, fibrillization is enhanced in protein-rich droplets. I suggest that LCD-mediated LLPS contributes to the assembly of stress granules and their liquid properties, and provides a mechanistic link between persistent stress granules and fibrillar protein pathology in disease
Seiser, Bernhard Josef. "Topologically close-packed phase prediction in Ni-based superalloys : phenomenological structure maps and bond-order potential theory." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:4298ebde-4b32-4dcc-b294-649493f9146c.
Full textGrüner, Daniel. "Untersuchungen zur Natur der Laves-Phasen in Systemen der Übergangsmetalle." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1172078219643-48967.
Full textSingh, Harmanjit. "Cytokine-binding and acute-phase plasma proteins in pigs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ31901.pdf.
Full textGrüner, Daniel. "Untersuchungen zur Natur der Laves-Phasen in Systemen der Übergangsmetalle." Doctoral thesis, Technische Universität Dresden, 2006. https://tud.qucosa.de/id/qucosa%3A24902.
Full textBarran, Perdita Elizabeth. "Studies of refractory clusters produced from a pulsed arc source." Thesis, University of Sussex, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244325.
Full textSengupta, Niladri. "Going beyond the Random Phase Approximation: A systematic assessment of structural phase transitions and interlayer binding energies." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/513054.
Full textPh.D.
The Random Phase Approximation and beyond Random Phase Approximation methods based on Adiabatic Connection Fluctuation Dissipation Theorem (ACFD) are tested for structural phase transitions of different groups of materials, including metal to metal, metal to semiconductor, semiconductor to semiconductor transitions. Also the performance assessment of semilocal density functionals with or without empirical long range dispersion corrections has been explored for the same cases. We have investigated the structural phase transitions of three broad group of materials, semi- conductor to metal transitions involving two symmetric structures, semiconductor to metal and wide bandgap semiconductor to semiconductor transitions involving at least one lower symmetric structure and lastly special cases comprising metal to metal transitions and transitions between energetically very close structural phases. The first group contains Si (diamond → β-tin), Ge (diamond → β-tin) and SiC (zinc blende → rocksalt), second group contains GaAs (zinc blende → cmcm) and SiO 2 (quartz → stishovite) and third group contains Pb (fcc → hcp), C(graphite → diamond) and BN (cubic → hexagonal) respectively. We have found that the difference in behavior of exchange and correlation in semilocal functionals and ACFD methods is striking. For the former, the exchange potential and energy often comprise the majority of the binding described by density functional approximations, and the addition of the correlation energy and potential often induce only a (relatively) small shift from the exchange- only results. For the ACFD, however, non self-consistent EXX typically underbinds by a considerable degree resulting in wildly inaccurate results. Thus the addition of correlation leads to very large shifts in the exchange-only results, in direct contrast to semilocal correlation. This difference in behavior is directly linked to the non-local nature of the EXX, and even though the exchange-only starting point is often nowhere close to experiment, the non-local correlation from the ACFD corrects this deficiency and yields the missing binding needed to produce accurate results. Thus we find the ACFD approach to be vital in the validation of semilocal results and recommend its use in materials where experimental results cannot be straightforwardly compared to other approximate electronic structure calculations. Utilizing the second-order approximation to Random Phase Approximation renormalized (RPAr) many-body perturbation theory for the interacting density-density response function, we have used a so-called higher-order terms (HOT) approximation for the correlation energy. In combination with the first-order RPAr correction, the HOT method faithfully captures the infinite- order correlation for a given exchange-correlation kernel, yielding errors of the total correlation energy on the order of 1% or less for most systems. For exchange-like kernels, our new method has the further benefit that the coupling-strength integration can be completely eliminated resulting in a modest reduction in computational cost compared to the traditional approach. When the correlation energy is accurately reproduced by the HOT approximation, structural properties and energy differences are also accurately reproduced, as confirmed by finding interlayer binding energies of several periodic solids and compared that to some molecular systems along with some phase transition parameters of SiC. Energy differences involving fragmentation have proved to be challenging for the HOT method, however, due to errors that do not cancel between a composite system and its constituent pieces which has been verified in our work as well.
Temple University--Theses
Lorenzo, Gotor Nieves 1984. "RNA-binding and prion domains : The Yin and Yang of phase separation." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668649.
Full textEls condensats biomoleculars actuen com a orgànuls sense membrana, organitzant el funcionament intern de la cèl·lula i regulant les reaccions bioquímiques que hi tenen lloc. Proteïnes i ARNs es separen en una fase diferent formant aquests condensats, però els dominis de les seves seqüències que propicien aquest procés encara no són clars. A través d’eines computacionals i de prediccions, he analitzat la habilitat de les seqüències del proteoma humà i de llevat de formar aquesta nova fase. A més, he avaluat experimentalment els dominis de la seqüència de Pub1, una proteïna de llevat. Els meus resultats indiquen que els dominis d’unió a ARN (RBDs) i els dominis similars a prions (PrLDs) tenen funcions diferents en el procés de separació de fases. Mentre que un PrLD pot liderar-ne la formació, diversos RBDs modulen les dinàmiques dintre del condensat. L’elevada capacitat d’interacció que tenen els PrLDs explica l’habilitat de reclutar molècules per formar condensats, però alhora compromet els equilibris i estabilitat cel·lulars (homeòstasi). La meva investigació revela informació sobre els principis que governen la formació i regulació d’orgànuls sense membrana.
Traiber, Ariel Javier Sebastián. "Electronic structure and phase equilibria in ternary substitutional alloys : a tight-binding approach." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/32661.
Full textIncludes bibliographical references (leaves 109-114).
by Ariel Javier Sebastián Traiber.
Ph.D.
McCarthy, Kelly A. "Exploiting Dynamic Covalent Binding for Strain-Specific Bacterial Recognition:." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:108513.
Full textAntibiotic resistance of bacterial pathogens poses an increasing threat to the wellbeing of our society and urgently calls for new strategies for infection diagnosis and antibiotic discovery. The overuse and misuse of broad-spectrum antibiotics has contributed to the antibiotic resistance crisis. Additionally, treatment of infections with broad-spectrum antibiotics can cause disruption to the host gut microbiome. The development of narrow-spectrum antibiotics would be ideal to avoid unnecessary cultivation of antibiotic resistance and damage to the human microbiota. Bacteria present many mechanisms of resistance, including modulating their cell surface with amine functionalities. In an age where infections are no longer responding to typical antibiotic treatments, novel drugs that target the characteristics of antibiotic resistance would be beneficial to remedy these defiant infections. Herein, we describe the utility of iminoboronate formation to target the amine- presenting surface modifications on bacteria, particularly those that display antibiotic resistance. Specifically, multiple 2-acetylphenylboronic acid warheads were incorporated into a peptide scaffold to develop potent peptide probes of bacterial cells. Further, by engineering a phage display library presenting the 2-acetylphenylboronic acid moieties, we were able to perform peptide library screens against live bacterial cells to develop reversible covalent peptide probes of target strains of bacteria. These peptide probes, which were developed for clinical strains of Staphylococcus aureus and Acinetobacter baumannii which display resistance, can label the target bacterium at submicromolar concentrations in a highly specific manner and in complex biological milieu. We further show that the identified peptide probes can be readily converted to bactericidal agents that deliver generic toxins to kill the targeted bacterial strain with high specificity. It is conceivable that this phage display platform is applicable to a wide array of bacterial strains, paving the way to facile diagnosis and development of strain-specific antibiotics. Furthermore, it is intriguing to speculate that even higher potency binding could be accomplished with better designed phage libraries with dynamic covalent warheads. This work is currently underway in our laboratory
Thesis (PhD) — Boston College, 2018
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
George, Miriam Thankam. "Immunological Characterization Of Duffy Binding Protein Of Plasmodium vivax." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5689.
Full textRabin, Clemence. "Investigation of RNA kissing complexes by native electrospray mass spectrometry : magnesium binding and ion mobility." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0892/document.
Full textBesides being the molecular intermediate between DNA and proteins, RNA can have many other functions such as gene regulation (riboswitches), gene expression (mRNA and tRNA) or catalysis (ribozymes). RNA function is linked to its structure and its folding dynamics. Cations such as magnesium bind to RNA and are in some instances essential for proper folding and for stability. The need of structural and thermodynamic details about Mg2+ interactions is then of upmost importance in the study of the structurefunction relationships. The first part of our work consists in characterizing the binding equilibria between magnesium and RNA model motifs, called kissing complexes, using native mass spectrometry (MS). MS makes it possible to distinguish individual binding stoichiometries, and the present work consisted in developing a method to quantify each species, taking into account the contribution of nonspecific adducts. We also explored how tandem mass spectrometry (MS/MS) could further help localizing magnesium ions. Further, we explored the structures of RNA complexes in the gas phase using ion mobility mass spectrometry (IMMS), with the aim to detect shape changes upon cation or ligand binding. But in contrast with anticipations, we found that DNA and RNA duplexes as well as RNA kissing complexes undergo a significant compaction at charge states naturally produced by native ESI-MS, which may hide the effect of cations. Our work showcases how mass spectrometry can bring novel information on RNA-cation binding stoichiometries and affinities, but also discusses some limitations of a gas-phase method to probe solution structures
Hoang, Tinyee Arden. "Application of ultra high hydrostatic pressure for investigating the binding of flavor compounds to ß-lactoglobulin via headspace solid phase microextraction-gas chromatography." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Dissertations/Fall2006/t_hoang_121206.pdf.
Full textJones, Andrew John Melvill. "The binding of an afimbrial bacterial surface adhesin to glycophorin using aqueous polymer two-phase partitioning." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26420.
Full textScience, Faculty of
Chemistry, Department of
Graduate
Lowe, Jeanette. "Phage Display to Identify Peptides Binding to or Penetrating the Mouse Zona Pellucida." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/35902.
Full textMaster of Science
Soomro, Saeeda. "C-C coupling reactions catalyzed by supported palladium in liquid phase /." München : Verl. Dr. Hut, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017719461&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textThiam, Moussa. "Development and Engineering Properties of Construction Materials Made Using Melted Plastics Wastes as the Only Binding Phase." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42638.
Full textWright, Emma. "The stepwise modification of carbon electrodes using electrochemical and solid phase synthesis for covalent binding of proteins." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/367131/.
Full textWheeler, Lucas. "The Evolution of Metal and Peptide Binding in the S100 Protein Family." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23178.
Full textLehtiö, Janne. "Functional studies and engineering of family 1 carbohydrate-binding modules." Doctoral thesis, KTH, Biotechnology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3211.
Full textThe family 1 cellulose-binding modules (CBM1) form a groupof small, stable carbohydrate-binding proteins. These modulesare essential for fungal cellulosedegradation. This thesisdescribes both functional studies of the CBM1s as well asprotein engineering of the modules for several objectives.
The characteristics and specificity of CBM1s from theTrichoderma reeseiCel7A and Cel6A, along with severalother wild type and mutated CBMs, were studied using bindingexperiments and transmission electron microscopy (TEM). Datafrom the binding studies confirmed that the presence of onetryptophan residue on the CBM1 binding face enhances itsbinding to crystalline cellulose. The twoT. reeseiCBM1s as well as the CBM3 from theClostridium thermocellumCipA were investigated by TEMexperiments. All three CBMs were found to bind in lineararrangements along the sides of the fibrils. Further analysesof the bound CBMs indicated that the CBMs bind to the exposedhydrophobic surfaces, the so called (200) crystalline face ofValoniacellulose crystals.
The function and specificity of CBM1s as a part of an intactenzyme were studied by replacing the CBM from the exo-actingCel7A by the CBM1 from the endoglucanase Cel7B. Apart fromslightly improved affinity of the hybrid enzyme, the moduleexchange did not significantly influence the function of theCel7A. This indicates that the two CBM1s are analogous in theirbinding properties and function during cellulosehydrolysis.
The CBM1 was also used for immobilization studies. Toimprove heterologous expression of a CBM1-lipase fusionprotein, a linker stability study was carried out inPichia pastoris. A proline/threonine rich linker peptidewas found to be stable for protein production in this host. Forwhole bacterial cell immobilization, theT. reeseiCel6A CBM1 was expressed on the surface of thegram-positive bacteria,Staphylococcus carnosus. The engineeredS. carnosuscells were shown to bind cellulosefibers.
To exploit the stable CBM1 fold as a starting point forgenerating novel binders, a phage display library wasconstructed. Binding proteins against an amylase as well asagainst a metal ion were selected from the library. Theamylase-binding proteins were found to bind and inhibit thetarget enzyme. The metal binding proteins selected from thelibrary were cloned on the surface of theS. carnosusand clearly enhanced the metal bindingability of the engineered bacteria.
Keywords: cellulose-binding, family 1carbohydrate-binding module, phage display, bacterial surfacedisplay, combinatorial protein library, metal binding, proteinengineering,Trichoderma reesei, Staphyloccus carnosus.
Rönning, Sanne. "Selection of a calcium-dependent IgG1-binding protein domain." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417065.
Full textLindgren, Joel. "Chemical Engineering of Small Affinity Proteins." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-141014.
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Krabacher, Rachel M. "Identifying Unique Material Binding Peptides Using a High Throughput Method." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1467888412.
Full textLe, Treut Guillaume. "Models of chromosome architecture and connection with the regulation of genetic expression." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS411/document.
Full textIncreasing evidences suggest that chromosome folding and genetic expression are intimately connected. For example, the co-expression of a large number of genes can benefit from their spatial co-localization in the cellular space. Furthermore, functional structures can result from the particular folding of the chromosome. These can be rather compact bundle-like aggregates that prevent the access to DNA, or in contrast, open coil configurations with several (presumably) globular clusters like transcription factories. Such phenomena have in common to result from the binding of divalent proteins that can bridge regions sometimes far away on the DNA sequence. The physical system consisting of the chromosome interacting with divalent proteins can be very complex. As such, most of the mechanisms responsible for chromosome folding and for the formation of functional structures have remained elusive.Using methods from statistical physics, we investigated models of chromosome architecture. A common denominator of our approach has been to represent the chromosome as a polymer with bending rigidity and consider its interaction with a solution of DNA-binding proteins. Structures entailed by the binding of such proteins were then characterized at the thermodynamical equilibrium. Furthermore, we complemented theoretical results with Brownian dynamics simulations, allowing to reproduce more of the biological complexity.The main contributions of this thesis have been: (i) to provide a model for the existence of transcrip- tion factories characterized in vivo with fluorescence microscopy; (ii) to propose a physical basis for a conjectured regulatory mechanism of the transcription involving the formation of DNA hairpin loops by the H-NS protein as characterized with atomic-force microscopy experiments; (iii) to propose a physical model of the chromosome that reproduces contacts measured in chromosome conformation capture (CCC) experiments. Consequences on the regulation of transcription are discussed in each of these studies
Nilvebrant, Johan. "An albumin-binding domain as a scaffold for bispecific affinity proteins." Doctoral thesis, KTH, Proteomik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-105425.
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Nilsson, Mikael. "Protein-DNA recognition : in vitro evolution and characterization of DNA-binding proteins /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4269.
Full textEsswein, Stefan Theo. "Probing protein-ligand interactions via solution phase hydrogen exchange mass spectrometry." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4638.
Full textGalkowski, Krzysztof. "Propriétés magnéto-optiques et microscopiques de perovskites organique-halogénure de plomb." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30265/document.
Full textThe hybrid organo-lead halide perovskites are an emerging class of materials, proposed for use as light absorbers in a new generation of photovoltaic solar cells. The chemical formula for these materials is APbX3, where A is an organic cation and X represents halide anions (most commonly Br-, Cl- or I-, or alloyed combination of these). The hybrid perovskies combine excellent absorption properties with large diffusion lengths and long lifetime of the carriers, resulting in photon conversion efficiencies as high as 22%. Another advantage is the inexpensiveness of the fabrication process. Therefore, with the rapid development of this class of materials, the perovskite photovoltaics has perspectives to outperform the well-established silicon technology. Here, we use optical methods to investigate the basic electronic properties and morphology in the thin films of several representatives of the hybrid perovskites. We study the compounds based on Methylammonium and Formamidinium organic cations; the iodides and wide band-gap bromides, showing how the chemical composition influences the investigated parameters. Using magneto-transmission, we directly determine the values of exciton binding energy and reduced mass. We find that the exciton binding energies at T = 2 K, varying from 14 to 25 meV, are smaller or comparable to the average thermal energy at room temperature (˜25 meV). Moreover, these values fall further at T = 160 K, to 10-24 meV. Based on that we conclude that the carriers photocreated in a perovskite material can be considered to be thermally ionized at room temperature. The measured reduced masses are in the range of 0.09-0.13 of the electron rest mass. We also show that both exciton binding energy and reduced mass depend linearly on the band gap energy. Therefore, the values of these parameters can be easily estimated for the synthesis of new perovskite compounds. With the spatially resolved photoluminescence, we probe the morphology of perovskite films with micrometer resolution, which enables us to observe single crystalline grains. The resulting maps show that all investigated thin films are composed from the dark and bright crystalline grains. We demonstrate that the low temperature phase transition from tetragonal to orthorhombic phase is incomplete in all studied materials, as the remains of the tetragonal phase are found even at T = 4 K. By investigating structurally damaged and photo annealed regions, where the occurrence of the tetragonal phase at low temperatures is enhanced, we attribute its presence to the depleted halide content
Lenkey, Nina M. "Using Phage Display to Select Peptides Binding to Type 8 Capsular Polysaccharide of Staphylococcus aureus." Youngstown State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ysu148611183162124.
Full textDai, Jing. "Adsorption, aggregation and phase separation in colloidal systems." Doctoral thesis, KTH, Tillämpad fysikalisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-220669.
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Maratani, Martin N. "Using Phage Display to Select Peptides Binding to Type 5 capsular polysaccharide ofStaphylococcus aureus." Youngstown State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1504010764721148.
Full textLi, Zheng. "Interactions of flavor compounds with soy and dairy proteins in model systems /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9974652.
Full textPadmanabhan, Kiran. "Translational Control of M Phase Progression: a dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/272.
Full textPadmanabhan, Kiran. "Translational Control of M Phase Progression: a dissertation." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/272.
Full textJaipuri, Firoz Ali. "Fluorous-tag assisted solution phase synthesis of mannose and heptomannose oligosaccharides and study of their binding interactions using carbohydrate microarray technology." [Ames, Iowa : Iowa State University], 2006.
Find full textFisher, James L. "Acute phase reactants prior to diagnosis of cancer or myocardial infarction /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406115155.
Full textMöller, Angeli. "Development of an intrabody capable of activating interferon regulatory factor-1 (IRF-1) and identification of IRF-1-binding peptide motifs." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5590.
Full textCui, Daniel. "Binding and expression analysis for identification of an antibody specific to T1, an RTK target." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1736.
Full textPerols, Anna. "Site-specific labeling of affinity molecules for in vitro and in vivo studies." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-152349.
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Joulie, Michaël. "Recherche de nouvelles protéines humaines se liant à l'ADN méthylé." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112157/document.
Full textEpigenetic phenomena are key contributors to the function of eukaryotic genomes. These processes act on chromatin, and they are used to render the genome dynamic, but also stable throughout successive rounds of cell division. Among epigenetic processes, DNA methylation is especially well known for its role in the regulation of gene expression.In mammals, DNA methylation is strongly correlated with transcriptional repression, and fulfills at least three essential roles. First, it maintains repeated sequences transcriptionally silenced, thus ensuring the stability of the genome. Second, it is responsible for the proper regulation of parentally imprinted genes, which are crucial regulators of embryonic development and adult life. Finally, DNA methylation ensures that some tissue-specific genes are kept inactive in the organs in which they should be repressed. Besides these roles in the physiology of normal cells, DNA methylation has strong links to cancer. Indeed the pattern of DNA methylation on the genome is frequently altered in cancer cells, and these anomalies contribute to transformation by several mechanisms.DNA methylation does not control transcription directly, but instead acts via a set of dedicated proteins that specifically recognize methylated DNA and repress transcription by acting at the chromatin level. At present, three families of such proteins, totalling 9 members altogether, are known in humans. However, several lines of evidence suggest that the list is not exhaustive, and that other human proteins that bind methylated DNA remain to be found. This was the goal of the current project.To this end, we opted for two distinct types approaches, an approach based on literature and a genetic approach. The study of candidate proteins does not allow us to identify new methylated DNA binding proteins and the genetic approach by phage display revealed two proteins of interest, HMGB1 and CHD3 that must now be validated by in vivo and in vitro approaches.Furthermore, we studied the regulation of DNA repeats by Zbtb4 in mice. Preliminary results show a regulation of minor satellites by Zbtb4. The role of this regulation will be analyse further in the future
Brady, Thomas Scott. "Bacteriophages for Treating American Foulbrood and the Neutralization of Paenibacillus larvae Spores." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/6929.
Full textBoutemy, Laurence S. "Analysis of the Interactions between the 5' to 3' Exonuclease and the Single-Stranded DNA-Binding Protein from Bacteriophage T4 and Related Phages." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1223979052.
Full textTypescript. "Submitted as partial fulfillment of the requirements for the Doctor of Philosophy in Chemistry." Includes bibliographical references (leaves 305-309).
Liu, Qingfeng. "Multi-phase modelling of multi-species ionic migration in concrete." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3133.
Full textBandmann, Nina. "Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification." Doctoral thesis, Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4318.
Full textHoward, Warren A. "Synthesis and characterisation of platinum(II) and ruthenium(II) polyamide conjugates." View thesis, 2008. http://handle.uws.edu.au:8081/1959.7/43899.
Full textA thesis presented to the University of Western Sydney, College of Health and Science, School of Biomedical and Health Sciences, in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographies.