Academic literature on the topic 'BFGF receptor'
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Journal articles on the topic "BFGF receptor"
Moscatelli, D., and N. Quarto. "Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin." Journal of Cell Biology 109, no. 5 (November 1, 1989): 2519–27. http://dx.doi.org/10.1083/jcb.109.5.2519.
Full textBikfalvi, A., S. Klein, G. Pintucci, N. Quarto, P. Mignatti, and D. B. Rifkin. "Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms." Journal of Cell Biology 129, no. 1 (April 1, 1995): 233–43. http://dx.doi.org/10.1083/jcb.129.1.233.
Full textMiyaji, Katsuya, Eiichi Tani, Atsuhisa Nakano, Hideyasu Ikemoto, and Keizo Kaba. "Inhibition by 5′-methylthioadenosine of cell growth and tyrosine kinase activity stimulated by fibroblast growth factor receptor in human gliomas." Journal of Neurosurgery 83, no. 4 (October 1995): 690–97. http://dx.doi.org/10.3171/jns.1995.83.4.0690.
Full textReiland, J., and A. C. Rapraeger. "Heparan sulfate proteoglycan and FGF receptor target basic FGF to different intracellular destinations." Journal of Cell Science 105, no. 4 (August 1, 1993): 1085–93. http://dx.doi.org/10.1242/jcs.105.4.1085.
Full textLiuzzo, JP, and D. Moscatelli. "Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: downmodulation of FGF receptors by phorbol ester." Blood 87, no. 1 (January 1, 1996): 245–55. http://dx.doi.org/10.1182/blood.v87.1.245.245.
Full textLiuzzo, JP, and D. Moscatelli. "Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: downmodulation of FGF receptors by phorbol ester." Blood 87, no. 1 (January 1, 1996): 245–55. http://dx.doi.org/10.1182/blood.v87.1.245.bloodjournal871245.
Full textSteinfeld, R., H. Van Den Berghe, and G. David. "Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican." Journal of Cell Biology 133, no. 2 (April 15, 1996): 405–16. http://dx.doi.org/10.1083/jcb.133.2.405.
Full textLiu, L., K. B. Pasumarthi, R. R. Padua, H. Massaeli, R. R. Fandrich, G. N. Pierce, P. A. Cattini, and E. Kardami. "Adult cardiomyocytes express functional high-affinity receptors for basic fibroblast growth factor." American Journal of Physiology-Heart and Circulatory Physiology 268, no. 5 (May 1, 1995): H1927—H1938. http://dx.doi.org/10.1152/ajpheart.1995.268.5.h1927.
Full textQuarto, N., D. Talarico, R. Florkiewicz, and D. B. Rifkin. "Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells." Cell Regulation 2, no. 9 (September 1991): 699–708. http://dx.doi.org/10.1091/mbc.2.9.699.
Full textMoscatelli, D. "Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells." Journal of Cell Biology 107, no. 2 (August 1, 1988): 753–59. http://dx.doi.org/10.1083/jcb.107.2.753.
Full textDissertations / Theses on the topic "BFGF receptor"
Preissler, Thales. "Interação funcional entre o receptor do peptídeo liberador de gastrina (GRPR) e o fator de crescimento de fibroblastro básico (bFGF) na formação da memória no hipocampo dorsal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/15478.
Full textGastrin-releasing peptide (GRP), a bombesin-like peptide, and its receptor, GRP receptor (GRPR) are found throughout the central nervous system (CNS), including limbic areas such as the hippocampus and amygdala, which are significantly involved in emotional responses, cognitive function, and, possibly, neurodegenerative and neuropsychiatric disorders. Increasing evidence indicates that the gastrin releasing peptide receptor (GRPR) is implicated in regulating synaptic plasticity and memory formation in the hippocampus and other brain areas. However, the molecular mechanisms underlying the memory-impairing effects of GRPR antagonism have remained unclear. bFGF is a polypeptide displaying stimulatory actions on proliferation, differentiation and motility of different cell types. In neurons, bFGF acts as neurotrophic factor that stimulates neuronal survival, and neurogenesis. Evidence of functional interactions between bFGF and the GRPR was provided by studies showing that GRPR antagonists inhibit the expression of bFGF in tumours. Here we report that basic fibroblast growth factor (bFGF/FGF-2) rescues the memory impairment induced by GRPR antagonism in the rat dorsal hippocampus. The GRPR antagonist [D-Tpi6, Leu13 psi(CH2NH)-Leu14] bombesin (6–14) (RC-3095) at 1.0g impaired, whereas bFGF at 0.25g enhanced, 24 h retention of inhibitory avoidance (IA) when infused immediately after training into the CA1 hippocampal area in male rats. Coinfusion with an otherwise ineffective dose of bFGF blocked the memory-impairing effect of RC-3095. These findings suggest that the memory-impairing effects of GRPR antagonists might be partially mediated by an inhibition in the function and/or expression of neuronal bFGF or diminished activation of intracellular protein kinase pathways associated with bFGF signaling.
Chen, Cheng. "Presynaptic differentiation at the neuromuscular junction : regulation by a novel bFGF-p120 catenin signaling pathway /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202007%20CHEN.
Full textHerre, Jürgen. "Dectin-1 : receptor internalisation, trafficking and biological effects in macrophages." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:bb525976-bfbf-4817-926b-c3686da071b5.
Full textPallarés, Quixal Judit. "Expresión de los factores angiogénicos VEGF y bFGF, y de los receptores FLK/ KDR y Flt-1 en la neoplasia intraepitelial prostática." Doctoral thesis, Universitat Autònoma de Barcelona, 2004. http://hdl.handle.net/10803/4226.
Full textVEGF ejerce sus funciones principalmente en las células endoteliales a través de dos receptores con acción tirosín quinasa FLK/ KDR (VEGFR2) y Flt-1( VEGFR2).
En el cáncer prostático se ha demostrado un aumento de la densidad vascular o angiogénesis en el carcinoma respecto al tejido normal, correlacionándose con otros marcadores pronósticos del cáncer prostático ya conocidos. Nuestro estudio ha demostrado un incremento de la densidad vascular y de la expresión de los factores angiogénicos VEGF y bFGF, y de los receptores FLK/ KDR y Flt-1 en la lesión precursora del cáncer de prostático, la neoplasia intraepitelial de alto grado (PINAG). Además, el aumento de la angiogénesis se ha correlacionado con los adenocarninomas prostáticos de alto grado de Gleason y estadios avanzados (pT3).
El aumento de la angiogénesis y la expresión de los factores angiogénicos y de sus receptores en la neoplasia intraepitelial de alto grado, apoya un papel de esta lesión como precursora en el cáncer prostático, y plantea su posible aplicación en biopsia por aguja en la próstata como marcador pronóstico adicional del adenocarcinoma prostático.
The process of angiogenesis is necessary for tumor growth beyond 2-3mm and for the development of metastasis. Vascular endothelial growth factor (VEGF) is the most potent angiogenic factor so far detected, and can function synergistically with Basic Fibroblastic growth factor (bFGF) inducing angiogenesis. VEGF acts upon binding to two tyrosine kinase receptors FLK/ KDR (VEGFR2) and Flt-1 (VEGFR2).
In prostate cancer the study of angiogenesis has revealed an increase in the microvessels density in the carcinoma compared to normal prostatic glands, and its has been correlated with pathological stage. Our results demostrated an increase in the vessels density and in the expression of the angiogenic factors VEGF and bFGF, and the receptors FLK/ KDR and Flt-1 in the prostatic intraepithelial neoplasia. Interestingly, angiogenesis also correlated with tumor grade and pathological stage (pT3).
The increased angiogenesis and expression of the angiogenic factors and their receptors in the prostatic intraepithelial neoplasia, support a premalignant role for this lesion, and suggest their application in prostatic core-biopsies as an additional prognostic factor in prostatic cancer.
Campos, Danila Barreiro. "Imunolocalização do VEGF, bFGF e seus receptores na placenta bovina e influência destes fatores sobre a produção de progesterona pelas células placentárias em cultura." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-05072006-093115/.
Full textPlacental establishment and function are dependent on intense vascularization. Placental vasculogenesis and angiogenesis are modulated by several factors, including VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor). Although the role of VEGF and bFGF during vascularization is already well established, some studies have indicated the participation of these growth factors as local modulators in other physiological functions, such as control of hormonal production in steroidogenic tissues. Cloned animals may exhibit alterations in gene expression during development modifying placental function. The aims of this study are to determine the tissue localization of VEGF, bFGF and their receptors in the bovine placenta and to evaluate the influence of bFGF and VEGF on placental progesterone production in non-cloned and cloned bovines. Placentomes from days 90, 150 and 210 of pregnancy were obtained at local slaughterhouse and placentomes from cloned and non-cloned gestations at 270 days were obtained after cesarean sections. Samples were fixed in 4% buffered formol solution, dehydrated and included in paraffin. Sections were subimitted to immunohistochemistry for subsequent localization of VEGF, bFGF and their receptors proteins. Under aseptic conditions, cells were mechanically dispersed and then cultivated in a 96-well plate. Growth factors were added at concentrations of 10 and 50 ηg/ml for bFGF and VEGF, respectively. Samples of culture medium and cells from control, bFGF, VEGF and bFGF plus VEGF groups were collected 24, 48 and 96 hours after growth factor addition. Progesterone concentrations were assessed by radioimmunoassay and protein content was measured by Lowry?s method. Data were analyzed by SAS (Statistical Analysis System) program, significant differences were compared by Duncan?s range multiple test. VEGF, bFGF and their receptors were localized in maternal and fetal epithelial and stromal cells and vascular endothelial cells during pregnancy in non-cloned animals and in cloned bovine placenta at 270 days of pregnancy. Bovine placental cells were able to produce different amounts of progesterone during pregnancy. Growth factors were able to influence progesterone production in placental cells only after 24 hours in culture. At 90 and 210 days of pregnancy VEGF stimulated progesterone production, while at 270 days of pregnancy the growth factor inhibited production of this hormone. bFGF stimulated progesterone production in placental cells from 90 days of pregnancy. Both growth factors together determined an increase in progesterone production in placental cells from 210 days of pregnancy. Progesterone production in placental cells from cloned cattle is similar when compared with non-cloned placental cells at the same gestational age and growth factors did not influence progesterone production in these cells. VEGF and bFGF, acting locally in the placental tissue, are modulators of the steroidogenic process, influencing in a time-dependent manner the progesterone production in this organ.
RIGACCI, STEFANIA. "Studio della distribuzione intracellulare e dei substrati in vivo della fosfotirosina proteina fosfatasi a basso peso molecolare." Doctoral thesis, 2000. http://hdl.handle.net/2158/822776.
Full text"Imunolocalização do VEGF, bFGF e seus receptores na placenta bovina e influência destes fatores sobre a produção de progesterona pelas células placentárias em cultura." Tese, Biblioteca Digital de Teses e Dissertações da USP, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-05072006-093115/.
Full textБень, Анжела Михайлівна. "Особливості поетики сучасної літературної казки (на матеріалі «ВДВ» Роальда Дала)." Магістерська робота, 2021. https://dspace.znu.edu.ua/jspui/handle/12345/5488.
Full textEN : The work is presented on 57 pages of printed text. The list of references includes 53 sources. The thesis presents the comprehensive study of the poetic features of the novel “BFG” by the famous modern British writer Roald Dahl whose books are very popular among young readers all over the world. The text of this novel is considered in the genre paradigm of centuries-old fairy-tale tradition. The study determines the interaction of the poetical elements of folk tales and literary tales written by some well-known English writers as well as to the author's innovation of R. Dahl. The work provides some insights into the problem of tale poetics in order to identify the features of folklore and literary tales. Special attention is paid to elucidating the formation of R. Dahl's creative personality and creating a holistic historical and literary vision of the creative work of this author against the background of the tradition of English literary tales. The target of this paper is to highlight the main features of the poetics of folk tales and to clarify the specifics of the transformation of the genre canon in the fairy tale by R. Dahl "BFG". A thorough analysis of the peculiarities of aesthetic tastes and intellectual demands of modern children has been conducted and it helps to discover the secrets of the immense popularity of “BFG” among the young readership. The study determines the special narrative strategies of Dahl which allow him to bring the text as close as possible to children's perception. The writer is proved to use the cinematographic principle of the plot sequence representation, numerous puns, black humor jokes, irony and specific author's neologisms, which form the original stylistic palette of the work. The practical significance of the thesis is that its results and conclusions can be used in the preparation of lectures on the theory of literature, history of foreign literature of the twentieth century, in the development of special courses on the history of English literature, and can be interesting for school teachers of foreign literature.
UA : Робота викладена на 57 сторінках друкованого тексту. Перелік посилань включає 53 джерела Об’єкт дослідження: казкова поетика в аспекті діахронії, від народно-поетичних зразків до сучасних літературних казок, зокрема, поетологічні особливості літературної казки-повісті відомого сучасного англійського письменника Р. Дала «ВДВ», які розглядаються під жанрологічним кутом зору. Мета роботи: виокремивши основні риси поетики фольклорної казки, з’ясувати специфіку трансформації жанрового канону в казковій повісті Р. Дала «ВДВ». Теоретико-методологічні засади: фундаментальні праці вітчизняних і зарубіжних вчених (Буслаєв і О. Афанасьєв, О. Веселовський, В. Пропп, С. Еплярд, С. Бремон, Л. І. Скуратовська, Ю. М. Романенко, І. В. Цикушева та ін.), сфокусовані на теоретичних та історико-літературних аспектах вивчення казки як жанру, а також наукові розвідки, присвячені творчості Р. Дала. Отримані результати: виявлено поетикальні особливості фольклорної та літературної казки; здійснено аналіз дефініцій та способів класифікації фольклорної та літературної казки; сформовано цілісне уявлення про специфіку формування творчої особистості Р. Дала та створено цілісну історико-літературну візію творчого доробку цього англійського автора на тлі традиції англійської літературної казки ; проаналізувано поетику повісті «ВДВ», виявлено її спільність з літературними традиціями та відмінності від них; а також окреслено кореляцію елементів казкової поетики «ВДВ» із запитами сучасного дитячого читацького загалу.
Book chapters on the topic "BFGF receptor"
Isacchi, A., L. Bergonzoni, M. Statuto, R. Chiesa, M. Rusnati, M. Presta, G. Ragnotti, and P. Sarmientos. "Activation of the tyrosine kinase receptor is not sufficient for the full biological activity of bFGF." In Experientia Supplementum, 101–6. Basel: Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7001-6_17.
Full textPresta, Marco, Marco Rusnati, Jeanette A. M. Maier, Chiara Urbinati, Massimo Statuto, Anna Gualandris, Ambra Pozzi, and Giovanni Ragnotti. "Basic Fibroblast Growth Factor and Endothelial Cells: Receptor Interaction, Signal Transduction, Cellular Response-Dissociation of the Mitogenic Activity of bFGF from its Plasminogen Activator-Inducing Capacity." In Angiogenesis in Health and Disease, 79–89. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3358-0_7.
Full textSavion, Naphtali, Anat Beit-Or, Shlomo Kotev-Emeth, and Sandu Pitaru. "Dexamethasone Modulates the Response of Rat Stromal Bone Marrow Derived Bone-Like Cells to bFGF and Igf-I." In Growth Factors, Peptides and Receptors, 115–26. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2846-3_12.
Full textConference papers on the topic "BFGF receptor"
Saksela, O., D. Moscatelli, and D. B. Rifkin. "THE OPPOSING OF BASIC FIBROBLAST GROWTH FACTOR AND TRANSFORMING GROWTH FACTOR BETA ON THE REGULATION OF PLASMINOGEN ACTIVATOR ACTIVITY IN CAPILLARY ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644660.
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