Journal articles: 'Beyond RPA'

1

Catara, F., N. Dinh Dang, and M. Sambataro. "Ground-state correlations beyond RPA." Nuclear Physics A 579, no. 1-2 (October 1994): 1–12. http://dx.doi.org/10.1016/0375-9474(94)90790-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

D'Rosario, Michael, and Carlene D'Rosario. "Beyond RoboDebt." International Journal of Strategic Decision Sciences 11, no. 2 (April 2020): 1–24. http://dx.doi.org/10.4018/ijsds.2020040101.

Full text

Abstract:

Automated decision support systems with high stake decision processes are frequently controversial. The Online Compliance Intervention (herewith “OCI” or “RoboDebt”) is a system of compliance implemented with the intention to facilitate automatic issuance of statutory debt notices to individuals, taking a receipt of welfare payments and exceeding their entitlement. The system appears to employ rudimentary data scraping and expert systems to determine whether notices should be validly issued. However, many individuals that take receipt of debt notices assert that they were issued in error. The commentary on the system has resulted in a lot of conflation of the system with other system types and caused many to question the role of decision of support systems in public administration given the potentially deleterious impacts of such systems for the most vulnerable. The authors employ a taxonomy of Robotic Process Automation (RPA) issues, to review the OCI and RPA more generally. This paper identifies potential problems of bias, inconsistency, procedural fairness, and overall systematic error. This research also considers a series of RoboDebt specific issues regarding contractor arrangements and the potential impact of the system for Australia's Indigenous population. The authors offer a set of recommendations based on the observed challenges, emphasizing the importance of moderation, independent algorithmic audits, and ongoing reviews. Most notably, this paper emphasizes the need for greater transparency and a broadening of criteria to determine vulnerability that encompasses, temporal, geographic, and technological considerations.

APA, Harvard, Vancouver, ISO, and other styles

3

KHVESHCHENKO, D. V., and IAN I. KOGAN. "ANYON SUPERCONDUCTIVITY BEYOND THE RANDOM PHASE APPROXIMATION." International Journal of Modern Physics B 05, no. 14 (August 20, 1991): 2355–83. http://dx.doi.org/10.1142/s0217979291000924.

Full text

Abstract:

We carry out a revision of the mechanism of anyon superconductivity found in the Random Phase Approximation. It is shown that the Debye screening of a statistical Coulomb-like interaction produced by contributions beyond the RPA destroys the abovementioned mechanism. The linear mode appeared in the particle-hole channel within the RPA is identified with a finite damping zero-sound. As an alternative mechanism an attraction of anyons which could lead to a formation of boson composites is observed. A finite temperature phase transition, hydrodynamics and electrodynamics of anyon system are described from this alternative point of view.

APA, Harvard, Vancouver, ISO, and other styles

4

Davesne, D., M. Oertel, and H. Hansen. "A consistent approximation scheme beyond RPA for bosons." European Physical Journal A 16, no. 1 (January 2003): 35–42. http://dx.doi.org/10.1140/epja/i2002-10075-y.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Litvinova, E., P. Ring, and V. Tselyaev. "Covariant response theory beyond RPA and its application." Physics of Atomic Nuclei 70, no. 8 (August 2007): 1380–85. http://dx.doi.org/10.1134/s1063778807080108.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Wolterink, T., V. M. Axt, and T. Kuhn. "Coulomb quantum kinetics beyond RPA and Born approximation." Physica B: Condensed Matter 314, no. 1-4 (March 2002): 132–35. http://dx.doi.org/10.1016/s0921-4526(01)01373-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Röpke, G., and A. Wierling. "Consistent Approximations for the Polarization Function Beyond RPA." Zeitschrift für Physikalische Chemie 204, Part_1_2 (January 1998): 159–69. http://dx.doi.org/10.1524/zpch.1998.204.part_1_2.159.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

GRASSO, M., D. GAMBACURTA, and F. CATARA. "COLLECTIVE MODES WITHIN SKYRME-SECOND RPA." Modern Physics Letters A 25, no. 21n23 (July 30, 2010): 1919–22. http://dx.doi.org/10.1142/s0217732310000642.

Full text

Abstract:

Second RPA calculations with a Skyrme force are performed to describe both high- and low-lying excited states in 16 O . The coupling between 1 particle-1 hole and 2 particle-2 hole as well as that between 2 particle-2 hole configurations are fully taken into account and the residual interaction is never neglected. For the rearrangement terms in the matrix elements beyond standard RPA two approximations are employed: they are either neglected or evaluated with the RPA procedure. A several-MeV shift of the strength distribution to lower energies is systematically found with respect to RPA distributions. A better description of the excitation energies of the low-lying 0+ and 2+ states is obtained with second RPA with respect to RPA.

APA, Harvard, Vancouver, ISO, and other styles

9

Denteneer, P. J. H., and J. M. J. van Leeuwen. "Spin waves in the 2D Hubbard model beyond the RPA." Physica B: Condensed Matter 199-200 (April 1994): 319–21. http://dx.doi.org/10.1016/0921-4526(94)91822-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

HOSOTANI, YUTAKA. "NEUTRAL AND CHARGED ANYON FLUIDS." International Journal of Modern Physics B 07, no. 12 (May 30, 1993): 2219–323. http://dx.doi.org/10.1142/s0217979293002857.

Full text

Abstract:

Properties of neutral and charged anyon fluids are examined, with the main focus on the question of whether or not a charged anyon fluid exhibits a superconductivity at zero and finite temperature. Quantum mechanics of anyon fluids is precisely described by Chern-Simons gauge theory. The random phase approximation (RPA), the linearized self-consistent field method (SCF), and the hydrodynamic approach employed in the early analysis of anyon fluids are all equivalent. Relations and differences between neutral and charged anyon fluids are discussed. It is necessary to go beyond RPA and the linearized SCF, and possively beyond the Hartree-Fock approximation, to correctly describe various phenomena such as the flux quantization, vortex formation, and phase transition.

APA, Harvard, Vancouver, ISO, and other styles

11

Fan, J. D., and Y. M. Malozovsky. "Electron correlation effects beyond the random phase approximation." International Journal of Modern Physics B 30, no. 13 (May 19, 2016): 1642006. http://dx.doi.org/10.1142/s0217979216420066.

Full text

Abstract:

The methods that have been used to deal with a many-particle system can be basically sorted into three types: Hamiltonian, field theory and phenomenological method. The first two methods are more popular. Traditionally, the Hamiltonian method has been widely adopted in the conventional electronic theory for metals, alloys and semiconductors. Basically, the mean-field approximation (MFA) that has been working well for a weakly coupled system like a metal is employed to simplify a Hamiltonian corresponding to a particular electron system. However, for a strongly coupled many-particle system like a cuprate superconductor MFA should in principle not apply. Therefore, the field theory on the basis of Green’s function and the Feynman diagrams must be invoked. In this method, one is however more familiar with the random phase approximation (RPA) that gives rise to the same results as MFA because of being short of the information for higher-order terms of interaction. For a strongly coupled electron system, it is obvious that one has to deal with higher-order terms of a pair interaction to get a correct solution. Any ignorance of the higher-order terms implies that the more sophisticated information contained in those terms is discarded. However, to date one has not reached a consensus on how to deal with the higher-order terms beyond RPA. We preset here a method that is termed the diagrammatic iteration approach (DIA) and able to derive higher-order terms of the interaction from the information of lower-order ones on the basis of Feynman diagram, with which one is able to go beyond RPA step by step. It is in principle possible that all of higher-order terms can be obtained, and then sorted to groups of diagrams. It turns out that each of the groups can be replaced by an equivalent one, forming a diagrammatic Dyson-equation-like relation. The diagrammatic solution is eventually “translated” to a four-dimensional integral equation. The method can be applied to a layered 2D system that is a model system of cuprate superconductors and others such as atomic, nuclear, heavy-fermion systems, etc.

APA, Harvard, Vancouver, ISO, and other styles

12

Kaneko, Kazunari. "Beyond RPA in nuclear rotation and wobbling motion at high spin." Physics Letters B 255, no. 2 (February 1991): 169–73. http://dx.doi.org/10.1016/0370-2693(91)90231-e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

PERDEW, JOHN P., and G. ROSENSTEEL. "METAL-SURFACE CORRELATION ENERGY FROM THE LIQUID DROP MODEL: A BACK-OF-THE-ENVELOPE ESTIMATE." Modern Physics Letters B 05, no. 16 (July 10, 1991): 1081–85. http://dx.doi.org/10.1142/s0217984991001325.

Full text

Abstract:

The liquid drop model applied to the one-electron problem provides an elementary estimate of the correlation contribution to the surface and curvature energies of jellium, in terms of bulk electron density and bulk correlation energy. Within the random phase approximation (RPA), this estimate correctly predicts the size of the surface correlation energy, its strong dependence upon bulk density, and its weak dependence upon surface density profile. The local density approximation (LDA) to RPA predicts surface correlation energies that are far too small, as a consequence of the LDA self-interaction error. Possible implications beyond RPA are discussed. The power and limitations of the liquid drop expansion are illustrated by the example of one-electron jellium spheroids.

APA, Harvard, Vancouver, ISO, and other styles

14

Kaniadakis, Antonios, and Laura Linturn. "Organizational adoption of Robotic Process Automation: managing the performativity of hype." International Journal of Information Systems and Project Management 10, no. 4 (November 30, 2022): 20–36. http://dx.doi.org/10.12821/ijispm100402.

Full text

Abstract:

Robotic process automation (RPA) has recently been subject to colossal hype. Although hype and expectations around technological innovation have been researched at length, there is limited research into the impact of hype at a firm level from an adopter’s perspective. Through an inductive multi-case study of five organizations from the banking, financial services and insurance (BFSI) sector that have adopted RPA over the past five years, we attempted to answer the question: how does RPA technology hype reach the shores of organizations and what adoption behaviour and decision making does it drive? Findings point to the critical role of senior management as instigators of adoption and legitimation, which goes beyond the sponsorship role identified in extant theory. Results also demonstrate that RPA adoption is driven by a ‘hunt’ for use cases by interdisciplinary teams, which exposes long-standing operational problems while at the same time offers opportunities for organizational learning. We contribute to a theoretical understanding of the organizational performativity of hype and draw lessons for industry practitioners considering RPA and other hyped technologies for organizational adoption.

APA, Harvard, Vancouver, ISO, and other styles

15

Beuerle, Matthias, Daniel Graf, Henry F. Schurkus, and Christian Ochsenfeld. "Efficient calculation of beyond RPA correlation energies in the dielectric matrix formalism." Journal of Chemical Physics 148, no. 20 (May 28, 2018): 204104. http://dx.doi.org/10.1063/1.5025938.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Montgomery, Fielding A., Noelle Stratton, Paul A. Bzonek, Sara E. Campbell, Rowshyra A. Castañeda, Emily S. Chenery, Kavishka Gallage, Tej Heer, Meagan M. Kindree, and Nicholas E. Mandrak. "The role of science advice in recovery potential assessments in freshwater fish listing decisions under the Canadian Species at Risk Act." FACETS 6 (January 1, 2021): 1247–59. http://dx.doi.org/10.1139/facets-2020-0091.

Full text

Abstract:

Fishes assessed as Threatened or Endangered by the Committee on the Status of Endangered Wildlife in Canada are disproportionately less likely to be listed under the federal Species at Risk Act (SARA) compared to other taxa. We examined the extent to which the amount and type of science advice in a Recovery Potential Assessment (RPA) contributes to SARA-listing decisions for 34 wildlife species of freshwater fishes in Canada. We used a generalized linear mixed model to describe SARA listing status as a function of RPA completeness. Principal coordinates analyses were conducted to assess similarity in answers to RPA questions among listed and nonlisted species. The amount and type of science advice within an RPA were weakly related to SARA status. RPA completeness accounted for only 7.4% of model variation when family was included as a random effect, likely because nine species not listed under SARA (64%) belong to the sturgeon family. Our results suggest that, while potentially useful for informing recovery strategies, RPAs do not appear to be driving listing status for freshwater fishes in Canada. Factors beyond scientific advice likely contribute to nonlisted species and delays in listing decisions.

APA, Harvard, Vancouver, ISO, and other styles

17

KVASIL, J., A. REPKO, V. O. NESTERENKO, W. KLEINIG, and P. G. REINHARD. "E1 STRENGTH IN LIGHT NUCLEI: SKYRME RPA ANALYSIS." International Journal of Modern Physics E 21, no. 05 (May 2012): 1250041. http://dx.doi.org/10.1142/s0218301312500413.

Full text

Abstract:

The giant dipole resonance (GDR) in N = 28 isotones (48 Ca , 50 Ti , 52 Cr , 54 Fe ) is analyzed in the framework of the Skyrme random-phase-approximation (RPA). Three Skyrme forces, SkM*, SLy6 and SV-bas, are used. The effects beyond RPA are simulated by the double folding procedure. We show that dipole strength exhibits a large collective shift, which testifies to a strong impact of the residual interaction and signals on considerable anharmonic effects. In 52 Cr , a significant pairing impact is found. For exception of 50 Ti , an acceptable agreement with the experiment data is obtained, which justifies the ability of Skyrme forces to describe GDR in light nuclei.

APA, Harvard, Vancouver, ISO, and other styles

18

Locatelli, Giada A., Helmut Pospiech, Nicolas Tanguy Le Gac, Barbara van Loon, Ulrich Hubscher, Sinikka Parkkinen, Juhani E. Syväoja, and Giuseppe Villani. "Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase ϵ in the presence of replication protein A and proliferating-cell nuclear antigen." Biochemical Journal 429, no. 3 (July 14, 2010): 573–82. http://dx.doi.org/10.1042/bj20100405.

Full text

Abstract:

DNA pol (polymerase) ϵ is thought to be the leading strand replicase in eukaryotes. In the present paper, we show that human DNA pol ϵ can efficiently bypass an 8-oxo-G (7,8-dihydro-8-oxoguanine) lesion on the template strand by inserting either dCMP or dAMP opposite to it, but it cannot bypass an abasic site. During replication, DNA pols associate with accessory proteins that may alter their bypass ability. We investigated the role of the human DNA sliding clamp PCNA (proliferating-cell nuclear antigen) and of the human single-stranded DNA-binding protein RPA (replication protein A) in the modulation of the DNA synthesis and translesion capacity of DNA pol ϵ. RPA inhibited the elongation by human DNA pol ϵ on templates annealed to short primers. PCNA did not influence the elongation by DNA pol ϵ and had no effect on inhibition of elongation caused by RPA. RPA inhibition was considerably reduced when the length of the primers was increased. On templates bearing the 8-oxo-G lesion, this inhibitory effect was more pronounced on DNA replication beyond the lesion, suggesting that RPA may prevent extension by DNA pol ϵ after incorporation opposite an 8-oxo-G. Neither PCNA nor RPA had any effect on the inability of DNA pol ϵ to replicate past the AP site, independent of the primer length.

APA, Harvard, Vancouver, ISO, and other styles

19

Papakonstantinou, P., R. Roth, and N. Paar. "Nuclear response using correlated realistic interactions: first-order random phase approximation and beyond." HNPS Proceedings 15 (January 1, 2020): 67. http://dx.doi.org/10.12681/hnps.2621.

Full text

Abstract:

A correlated realistic interaction derived within the Unitary Correlation Operator Method (UCOM) based on the Argonne V18 nucleon-nucleon potential is used in calculations of nuclear response for closed-shell nuclei. Giant resonances are examined in the framework of the random-phase approximation (RPA). The effects of explicit ground-state correla- tions and of higher than first-order configurations are discussed.

APA, Harvard, Vancouver, ISO, and other styles

20

Jędrzejka, Dariusz. "Robotic process automation and its impact on accounting." Zeszyty Teoretyczne Rachunkowości 2019, no. 105 (161) (December 22, 2019): 137–66. http://dx.doi.org/10.5604/01.3001.0013.6061.

Full text

Abstract:

The paper seeks to explain the concept of robotic process automation (RPA), the ways it impacts accounting, and suggest future research directions. A literature review of previous studies and state-of-the-art sources has been conducted to reveal research gaps. The results provide insights into the nature of the accounting transformation. The potential for automating accounting processes with RPA is high, and robots are predicted to replace accountants for a considerable part of their tasks. That could lead to the disappearance of entry-level accounting positions and, simultaneously, the creation of new accountant roles. Future accountants’ responsibilities will go beyond bookkeeping and financial reporting towards business advisory and leading the RPA transformation. The change entails the need to improve their soft skills, and technology and data skills. It calls for more studies on an effective method to integrate these skills into the accounting education model. Further research is required to examine the potential negative effects of employing robots. These relate to the unnecessary human-robot competition, unintended organisational structure changes, deskilling, and building expertise and knowledge management. Finally, to obtain a more comprehensive view of the impacts of RPA performance, more in-depth research is needed to account for all the financial and non-financial effects of RPA implementation.

APA, Harvard, Vancouver, ISO, and other styles

21

MARIANO, A. "THE NUMBER SELF-CONSISTENT RENORMALIZED RANDOM PHASE APPROXIMATION." International Journal of Modern Physics B 20, no. 30n31 (December 20, 2006): 5334–37. http://dx.doi.org/10.1142/s0217979206036442.

Full text

Abstract:

RPA and its quasiparticle generalization (QRPA) have been widely used to study electromagnetic transitions and beta decays in medium and heavy nuclei, being the pn-QRPA charge exchange mode extensively employed in the description of single and double beta decays in vibrational nuclei. However develops a collapse, i.e. it presents imaginary eigen-values for strengths beyond a critical value of the force. Extensions called renormalized QRPA (RQRPA) do not develop any collapse going beyond the simplest quasiboson approximation, however they present several drawbacks which will be analyzed.

APA, Harvard, Vancouver, ISO, and other styles

22

Li, JiaXin, Moo Hyun Kim, LongZhe Guo, Kai Song, Eun-Seok Shin, Soe Hee Ann, Soo Jin Kim, et al. "Impact of CYP2C19 Polymorphism on Antiplatelet Potency of Prasugrel 5 and 10 mg Daily Maintenance." Cardiology 140, no. 3 (2018): 155–62. http://dx.doi.org/10.1159/000491598.

Full text

Abstract:

Background: Whether genetic polymorphisms (GP) impact residual platelet aggregation (RPA) following prasugrel is unclear, especially during maintenance phase. We assessed the influence of CYP2C19 GP carriers on RPA in the prospective observational cohort study. Methods and Results: All post-stent patients (n = 206) received prasugrel 60 mg loading and either 5 or 10 mg daily maintenance with aspirin100 mg. RPA levels by light transmission aggregometry (LTA), multiplate electrode aggregometry (MEA), and VerifyNow (P2Y12 reaction units, PRU) with CYP2C19 GP were measured simultaneously. Demographics and clinical characteristics were not useful for predicting response after prasugrel. GP carriers exhibited higher RPA (PRU: p = 0.001, LTA: p = 0.001, MEA: p = 0.023) than noncarriers. CYP2C19 carriers had higher RPA for 5 mg (n = 35; LTA: p = 0.043, MEA: p = 0.023) and reached significance for 10 mg (n = 27; LTA: p = 0.001, PRU: p = 0.001) prasugrel. When divided into extensive, intermediate, and poor metabolizers, all exhibited statistical differences among the 3 groups (LTA: 14.9 ± 12.3%, 22.6 ± 14.9%, 22.9 ± 15.6%, p = 0.002; PRU: 104.1 ± 70.8%, 141.8 ± 78.0%, 151.0 ± 84.8%, p = 0.003; MEA: 19.7 ± 8.9%, 24.4 ± 12.2%, 28.1 ± 14.7%, p = 0.002). Conclusion: CYP2C19 GP impacts RPA during maintenance phase prasugrel in Korean outpatients. This effect is consistent for both of the approved prasugrel doses potentially affecting long-term outcomes including bleeding risks. However, the clinical utility of these findings is still uncertain, and requires more evidence from larger randomized trials beyond East Asians.

APA, Harvard, Vancouver, ISO, and other styles

23

Venø, Susanne T., Tomasz Kulikowicz, Cezar Pestana, Piotr P. Stepien, Tinna Stevnsner, and Vilhelm A. Bohr. "The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus." Biochemical Journal 440, no. 2 (November 14, 2011): 293–300. http://dx.doi.org/10.1042/bj20100991.

Full text

Abstract:

The hSuv3 (human Suv3) helicase has been shown to be a major player in mitochondrial RNA surveillance and decay, but its physiological role might go beyond this functional niche. hSuv3 has been found to interact with BLM (Bloom's syndrome protein) and WRN (Werner's syndrome protein), members of the RecQ helicase family involved in multiple DNA metabolic processes, and in protection and stabilization of the genome. In the present study, we have addressed the possible role of hSuv3 in genome maintenance by examining its potential association with key interaction partners of the RecQ helicases. By analysis of hSuv3 co-IP (co-immunoprecipitation) complexes, we identify two new interaction partners of hSuv3: the RPA (replication protein A) and FEN1 (flap endonuclease 1). Utilizing an in vitro biochemical assay we find that low amounts of RPA inhibit helicase activity of hSuv3 on a forked substrate. Another single-strand-binding protein, mtSSB (mitochondrial single-strand-binding protein), fails to affect hSuv3 activity, indicating that the functional interaction is specific for hSuv3 and RPA. Further in vitro studies demonstrate that the flap endonuclease activity of FEN1 is stimulated by hSuv3 independently of flap length. hSuv3 is generally thought to be a mitochondrial helicase, but the physical and functional interactions between hSuv3 and known RecQ helicase-associated proteins strengthen the hypothesis that hSuv3 may play a significant role in nuclear DNA metabolism as well.

APA, Harvard, Vancouver, ISO, and other styles

24

Zhang, C. "Electromagnetic Absorption in Two-dimensional Systems under a Magnetic Field and a Unidirectional Periodic Potential." Australian Journal of Physics 53, no. 1 (2000): 65. http://dx.doi.org/10.1071/ph99024.

Full text

Abstract:

The absorption of electromagnetic waves by a high mobility two-dimensional electron gas subjected to a magnetic field and a weak periodic potential is investigated. We show that the periodic modulation on the Laudau states has a profound effect on the absorption of electromagnetic waves. We develop a formalism which treats the electron–electron interaction beyond the random-phase-approximation (RPA) and includes the electron-impurity scattering in the lowest order. A RPA dielectric function was employed to study the electromagnetic absorption in modulated systems. Simultaneous excitation of an electron–hole pair with finite momentum contributes significantly to the absorption around and below the cyclotron frequency. Such a process is absent for a uniform electron gas under a magnetic field.

APA, Harvard, Vancouver, ISO, and other styles

25

LOMBARDO, UMBERTO, CAIWAN SHEN, HANS-JOSEF SCHULZE, and WEI ZUO. "SUPERFLUID STATES OF NUCLEAR MATTER BEYOND THE BCS APPROXIMATION." International Journal of Modern Physics E 14, no. 04 (June 2005): 513–54. http://dx.doi.org/10.1142/s0218301305003375.

Full text

Abstract:

The recent progress in the pairing problem and the superfluidity of neutron stars is reviewed. The theory of superfluidity in nuclear and neutron matter is developed beyond the BCS approximation. In particular, the dispersion effects including the depletion of the Fermi surface and the core polarization are discussed within the Brueckner theory. In addition, the effects of vertex correction to the pairing interaction, based on RPA, are incorporated in the generalized gap equation. The isospin singlet (neutron–proton) pairing is investigated in connection with the low-density crossover from a superfluid Fermi system to a Bose–Einstein condensate and the isospin suppression of pairing in neutron-rich matter. The onset of different superfluid states of neutron–neutron and proton–proton pairing in neutron stars is discussed in the context of application to rotational motion and cooling process.

APA, Harvard, Vancouver, ISO, and other styles

26

Serrano, Myra, and Venessa Sposari. "Searching for missing donors: a 12-month audit of deaths in two large Sydney teaching hospitals." Transplant Journal of Australasia 28, Volume 28 Issue 2 (August 7, 2019): 18–21. http://dx.doi.org/10.33235/tja.28.2.18-21.

Full text

Abstract:

The DonateLife Audit (DLA) is undertaken at Liverpool and Royal Prince Alfred (RPA) hospitals to measure and report on actual and potential organ donation activity. This includes all patient deaths in the intensive care unit (ICU) and emergency department (ED); and, patients with a neurological condition who died within 24 hours of discharge from ICU or ED. A death review committee was established in RPA in mid-2014 and Liverpool in mid-2017 to analyse all in-hospital deaths to determine whether these hospitals were missing potential organ donors beyond the DLA parameters. The two death review committees analysed 12 months of data for comparison. The findings showed that both hospitals have a low rate of potential organ donors who died from non-neurological conditions. It also highlighted a significant number of unsupportable patients who presented in extremis in Liverpool and a significant number of patients with no suitable organs in RPA. It can be inferred that these limit the potential donor pool and therefore further exploration of these phenomena is warranted.

APA, Harvard, Vancouver, ISO, and other styles

27

Silva, Luciana Bosco e. "A MUSEOGRAFIA CONTEMPORÃ‚NEA E A EXIBIÃ‡ÃƒO DE INSTALAÃ‡Ã•ES." Pensar Acadêmico 4, no. 1 (April 16, 2019): 4–8. http://dx.doi.org/10.21576/rpa.2011v7i1.1052.

Full text

Abstract:

The spectacularity of museography appears in the contemporary as an antagonÃsm of the white cube of modern age, creating special/space worlds for the exhibition of art. From that point, the curator puts himself, in a way, as co-author of the piece of art, regarding the presentation of the work of art, specially on contemporary art, being on many cases the essence of the work itself.Â The exhibition put itself on the categoty of an event, as the International Expos on 20th century. The exhibition as event/show appears on the end of 20th century, in special in the 90, bringing with it a severa! numbers of adepts and critics."lt's bom a new esthetics of exhibition, in witch assemble the curator take cver the rol! that is beyond the assemble of canvas, sculptures, objects or installation art. The curator conceives the exhibition as a criticai project that is shared with the artist himself (if he is still alive)". (GONÃ‡ALVES, L., 2004, p. 41).Â The curator puts himself on a very important roll in the way of how the visitor will interact with the art piece, he becomes responsible for this relationship, creating with this a new reality in witch the work of art will be, in a way, rediscover allowing news forms of reading of the same work of art, depending on the look or the intention of the curator.Besides the manner of the theatricality and the others effects proponent by the curator, Ãn the specific case of Installation Art, there is still the question of how the piece is assemble, in witch case it could actually change its expression, own essence depending on how it is exhibit.Â

APA, Harvard, Vancouver, ISO, and other styles

28

KVASIL, J., V. O. NESTERENKO, W. KLEINIG, D. BOŽÍK, and P. G. REINHARD. "SKYRME–HARTREE–FOCK DESCRIPTION OF THE DIPOLE STRENGTH IN NEUTRON-RICH TIN ISOTOPES." International Journal of Modern Physics E 20, no. 02 (February 2011): 281–91. http://dx.doi.org/10.1142/s0218301311017636.

Full text

Abstract:

Low-energy E1 strength in neutron-rich 132-164 Sn isotopes is analyzed in the framework of the Skyrme random phase approximation (RPA) with different Skyrme forces. A double folding procedure is applied to take into account the energy-dependent width effects beyond RPA. All the considered Skyrme forces indicate a soft prolate deformation in the open shell isotopes 142-164 Sn . The integrated E1 strength in the energy region of the pygmy resonance grows with the neutron number. The influence of deformation on the integrated strength near the particle emission thresholds (which is of a keen astrophysical interest) is strictly suppressed by the mutual compensation effect for the branches of the giant dipole resonance. The results obtained are in a good agreement with the previous findings of the relativistic mean field model.

APA, Harvard, Vancouver, ISO, and other styles

29

Kelm, Jeremy M., Jitender Dev Gaddameedi, Pamela S. VanderVere-Carozza, Amirreza Samarbakhsh, Nivisa Vakeesan, Hussein W. Kansou, Sara Serafimovski, Katherine S. Pawelczak, John J. Turchi, and Navnath S. Gavande. "Abstract 802: Development of replication protein A (RPA) targeted PROTACs for the treatment of lung and ovarian cancers." Cancer Research 82, no. 12_Supplement (June 15, 2022): 802. http://dx.doi.org/10.1158/1538-7445.am2022-802.

Full text

Abstract:

Abstract Despite remarkable advances within the field of molecular cancer therapeutics over the preceding decades, DNA-damaging agents retain a central role in the pharmacotherapy of neoplastic diseases. The clinical response to DNA-damaging therapies is varied within and across cancer subtypes where a robust DNA damage response (DDR) predicts recalcitrance. Replication protein A (RPA) is the predominant human single-stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination, and the DNA-damage response (DDR). Inhibition of the RPA−DNA interaction is an approach to cancer drug discovery that holds potential to provide single-agent activity and/or synergy with existing therapeutics. Proteolysis targeting chimera (PROTAC) based drug design presages a paradigm shift within drug discovery as PROTACs begin to carve out a space in the clinical landscape. The PROTAC platform is particularly suited for drugging overexpressed proteins such as RPA because iterative target degradation improves drug:target stoichiometry and precludes RPA’s role in protein scaffolding. Herein, we describe the synthesis and biological evaluation of an RPA targeted PROTAC library conceived by conjugation of the diaryl pyrazole RPA inhibitor TDRL-551 and an E3-ligand via a linker of variable length and composition. Residing within the beyond rule of five (bRo5) chemical space, careful consideration was given to minimize the liability to cell permeability imposed by the high molecular weight of PROTACs. Excitingly, cellular uptake across the compound library was broadly improved relative to the unconjugated warhead TDRL-551. Similarly, RPA engagement by the PROTAC series was widely unhindered and, in many cases, improved relative to the warhead TDRL-551. A subset of the compound library unified by flexible linkers and alkyne attachment of the E3-ligand (typified by GL-3311) display low single-digit micromolar IC50 values in viability assays across H460, A549, and A2780 cell lines. Citation Format: Jeremy M. Kelm, Jitender Dev Gaddameedi, Pamela S. VanderVere-Carozza, Amirreza Samarbakhsh, Nivisa Vakeesan, Hussein W. Kansou, Sara Serafimovski, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande. Development of replication protein A (RPA) targeted PROTACs for the treatment of lung and ovarian cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 802.

APA, Harvard, Vancouver, ISO, and other styles

30

WESSELINOWA, J. M., and A. T. APOSTOLOV. "DYNAMICAL STRUCTURE FACTOR FOR s - f MODEL WITH SPIN-PHONON INTERACTION." International Journal of Modern Physics B 10, no. 22 (October 10, 1996): 2797–809. http://dx.doi.org/10.1142/s0217979296001264.

Full text

Abstract:

A Green's function technique is used to study the effects of spin–phonon interaction in ferromagnetic semiconductors based on the s - f model. The spin wave energy and the damping are evaluated for the first time beyond the RPA and numerically calculated. They increase with increasing spin–phonon interaction. The dependence of the dynamical structure factor on temperature and on spin–phonon interaction is discussed. At fixed T with increasing spin–phonon interaction the peak height decreases, the half-width increases, whereas the peak shifts to higher energy values.

APA, Harvard, Vancouver, ISO, and other styles

31

Press, Robert H., Sarah L. Shafer, Renjian Jiang, Zachary S. Buchwald, Mustafa Abugideiri, Sibo Tian, Tiffany Morgan, et al. "The timing of chemoradiotherapy after surgical resection and its impact on overall survival in glioblastoma." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 2051. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.2051.

Full text

Abstract:

2051 Background: Prior studies examining time to initiate chemoradiotherapy (CRT) after surgical resection (S) in glioblastoma (GBM) have not provided clear consensus on its clinical impact. We sought to evaluate the effect that differential timing of adjuvant therapy may have on overall survival (OS). Methods: With the National Cancer Database (NCDB), patients (pts) with GBM who underwent S and adjuvant CRT from 2004-2013 were analyzed. Analysis was performed for the entire cohort as well as by Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) classes (i.e. I, II, and III). Time from S to CRT was grouped weekly (i.e. 0-1, 1-2, 2-3, 3-4, 4-5, 5-6, 6-7, 7-8, and > 8 weeks). Pts were excluded if they died within the first 8 weeks to account for immortal time bias. Kaplan-Meier analysis, log-rank testing, and multivariate (MVA) Cox proportional hazards regression were performed with OS as the primary outcome. Results: A total of 30,414 pts were included for analysis. RPA class I, II, and III contained 903, 4,347, and 25,164 pts, respectively. The most common time to initiate CRT was week 4-5 (n = 7389), and this group served as reference for survival analysis. On MVA, weeks 0-1 (hazard ratio [HR] 1.18, 95% confidence interval [CI] 1.02-1.35), 1-2 (HR 1.24, CI 1.17-1.32), and 2-3 (HR 1.11, CI 1.07-1.15) demonstrated worse OS (all p < 0.03). For RPA class I pts, week 1-2 (HR 2.07, CI 1.08-3.95) was associated with worse OS (p = 0.028). For RPA class II pts, weeks 1-2 (HR 1.34, CI 1.14-1.57), 2-3 (HR 1.18, CI 1.07-1.31), and 3-4 (HR 1.10, CI 1.0-1.21) were associated with worse OS (all p < 0.05). For RPA class III pts, weeks 0-1 (HR 1.18, CI 1.02-1.38), 1-2 (HR 1.22, CI 1.14-1.3), and 2-3 (HR 1.09, CI 1.05-1.14) were associated with worse OS (all p < 0.03). No time point after week 5 was associated with change in OS for the overall cohort or any RPA class subgroup. Conclusions: These data provide insight into the optimal timing of CRT in GBM and describe RPA-class specific outcomes. In general, OS was negatively impacted if CRT started less than 3 weeks from S. Waiting up to 8 weeks, however, was not detrimental to OS and suggests delaying CRT beyond week 4-5 should be considered if clinically indicated without undue concern.

APA, Harvard, Vancouver, ISO, and other styles

32

Kompelli, Anvesh Reddy, Hong Li, and David Michael Neskey. "Impact of Delay in Treatment Initiation on Overall Survival in Laryngeal Cancers." Otolaryngology–Head and Neck Surgery 160, no. 4 (October 16, 2018): 651–57. http://dx.doi.org/10.1177/0194599818803330.

Full text

Abstract:

Objective Delayed treatment significantly affects survival in head and neck cancer, but defining delays for specific subsites remains controversial. The purpose of this study is to elicit the time point for delay in treatment initiation in all laryngeal cancers using a large cohort of patients within the National Cancer Database (NCDB). Study Design A retrospective cohort study. Setting NCDB. Subjects and Methods Patients with laryngeal cancer within the NCDB from 2006 to 2014 were identified. A recursive partition analysis (RPA) was performed to identify the time point at which delay contributed to increased hazard. Patients were stratified into 3 groups: no delay, at risk, and overtly delayed. Kaplan-Meier method was used to compare overall survival of these cohorts. Multivariate logistic regression analysis was used to identify predictors of delay. A multivariate Cox regression model was used to identify the final covariates that significantly affect overall survival. Results RPA identified the threshold for delay becomes significant at 46 days and exceeds baseline hazard at 73 days. Delay beyond 73 days is associated with a 16.1-month decrease in median survival ( P < .001). To ensure this was not due to any confounding variables, a subsequent Cox multivariate regression confirmed a significantly increased adjusted hazard ratio (HR) for patients who were at risk or delayed (adjusted HR [confidence interval], 1.09 [1.04-1.15] and 1.26 [1.18-1.35], respectively). Conclusion Treatment of laryngeal cancer requires a multidisciplinary approach, and coordinating this care can take time. Our study highlights that delay beyond 46 to 73 days significantly affects survival and identifies patients experiencing these delays.

APA, Harvard, Vancouver, ISO, and other styles

33

Ahn, Byungchan, Jae Wan Lee, Hana Jung, Gad Beck, and Vilhelm A. Bohr. "Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand." PLoS ONE 4, no. 3 (March 5, 2009): e4673. http://dx.doi.org/10.1371/journal.pone.0004673.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Reinholz, H. "A Generalised Linear Response Theory applied to the Dielectric Function of Coulomb Systems." Australian Journal of Physics 53, no. 1 (2000): 133. http://dx.doi.org/10.1071/ph99049.

Full text

Abstract:

A generalised linear response theory is used to derive the dielectric function at arbitrary wave numbers k and frequencies w for interacting quantum systems. The connection to thermodynamic Green functions allows the systematic perturbative treatment going beyond RPA and treating local field corrections as well as the inclusion of collisions on the same footing. Emphasis will be on the demonstration of the formalism. Results will be presented for the three-dimensional as well as two-dimensional case of an interacting electron gas. In the long-wavelength limit, a Drude-type expression with frequency dependent relaxation time is given bridging the theories of dielectric function and electrical conductivity.

APA, Harvard, Vancouver, ISO, and other styles

35

Marilao, Paula. "Autismo infantil: bajo las profundidades de una asombrosa realidad." Revista Pensamiento Académico 1, no. 2 (December 6, 2018): 13–23. http://dx.doi.org/10.33264/rpa.201802-02.

Full text

Abstract:

En este artículo se presenta la emergencia de un niño con Trastorno del Espectro Autista, luego de una intervención psicoterapéutica de orientación psicodinámica. En la primera parte se aborda la evolución histórica del cuadro clínico, sus criterios diagnósticos e indicadores clínicos. Se presentan los antecedentes generales del niño y las características clínicas propias del diagnóstico de Trastorno del Espectro Autista encarnadas en aquel niño. Además, del foco de la intervención psicoterapeútica. En una segunda parte, se expone parte del proceso de intervención, el descenso de las defensas autistas, la integración del Objeto y la adquisición de significantes en la interacción con Otro, y cómo dichas interacciones influyen en el bienestar físico, psicológico y social de un niño con Trastorno del Espectro Autista. Además, de realizar una visión comprensiva del psiquismo de un niño con Trastorno del Espectro Autista más allá de las clasificaciones nosológicas, a fin de dar cuenta de las formas de acercarse al mundo y defenderse del desmantelamiento y la autosensorialidad, para emerger del encapsulamiento y acercarse a sí mismo, a través del contacto con Otro. In this article, we present the emergence of a child with Autism Spectrum Disorder, after a psychotherapeutic intervention with psychodynamic orientation. The first part deals with the historical evolution of the clinical picture, the diagnostic criteria and clinical indicators. The general antecedents of the child and the clinical characteristics of the diagnosis of Autism Spectrum Disorder embodied in that child are presented. Also, the focus of the psychotherapeutic intervention. In a second part, part of the intervention process is exposed, the decrease of the autistic defenses, the integration of the Object and the acquisition of signifiers in the interaction with Others, and how these interactions influence the physical, psychological and social well-being of a child with Autism Spectrum Disorder. In addition, to realize a comprehensive vision of the psyche of a child with Autism Spectrum Disorder beyond the nosological classifications, in order to account for the ways of approaching the world and defend themselves from dismantling and self-sensing, to emerge from the encapsulation and approach himself, through contact with Other.

APA, Harvard, Vancouver, ISO, and other styles

36

REBEI, A., and W. N. G. HITCHON. "CORRELATION ENERGY OF AN ELECTRON GAS: A FUNCTIONAL APPROACH." International Journal of Modern Physics B 17, no. 07 (March 20, 2003): 973–1009. http://dx.doi.org/10.1142/s0217979203015851.

Full text

Abstract:

Correlation effects of an electron gas in an external potential are derived using an Effective Action functional method. Corrections beyond the random phase approximation (RPA) are naturally incorporated by this method. The Effective Action functional is made to depend explicitly on two-point correlation functions. The calculation is carried out at imaginary time. For a homogeneous electron gas, we calculate the effect of exchange on the ring diagrams at zero temperature and show how to include some of the ladder diagrams. Our results agree well with known numerical calculations. We conclude by showing that this method is in fact a variant of the time dependent density functional method and suggest that it is suitable to be applied to the study of correlation effects in the non-homogeneous case.

APA, Harvard, Vancouver, ISO, and other styles

37

Leonardo, Sandra, Anna Toldrà, and Mònica Campàs. "Biosensors Based on Isothermal DNA Amplification for Bacterial Detection in Food Safety and Environmental Monitoring." Sensors 21, no. 2 (January 16, 2021): 602. http://dx.doi.org/10.3390/s21020602.

Full text

Abstract:

The easy and rapid spread of bacterial contamination and the risk it poses to human health makes evident the need for analytical methods alternative to conventional time-consuming laboratory-based techniques for bacterial detection. To tackle this demand, biosensors based on isothermal DNA amplification methods have emerged, which avoid the need for thermal cycling, thus facilitating their integration into small and low-cost devices for in situ monitoring. This review focuses on the breakthroughs made on biosensors based on isothermal amplification methods for the detection of bacteria in the field of food safety and environmental monitoring. Optical and electrochemical biosensors based on loop mediated isothermal amplification (LAMP), rolling circle amplification (RCA), recombinase polymerase amplification (RPA), helicase dependent amplification (HDA), strand displacement amplification (SDA), and isothermal strand displacement polymerisation (ISDPR) are described, and an overview of their current advantages and limitations is provided. Although further efforts are required to harness the potential of these emerging analytical techniques, the coalescence of the different isothermal amplification techniques with the wide variety of biosensing detection strategies provides multiple possibilities for the efficient detection of bacteria far beyond the laboratory bench.

APA, Harvard, Vancouver, ISO, and other styles

38

Watanabe, Shigeru, Kazumichi Matsushita, Paul B. McCray, and John B. Stokes. "Developmental expression of the epithelial Na+ channel in kidney and uroepithelia." American Journal of Physiology-Renal Physiology 276, no. 2 (February 1, 1999): F304—F314. http://dx.doi.org/10.1152/ajprenal.1999.276.2.f304.

Full text

Abstract:

The epithelial Na+ channel (ENaC) plays an important role in regulating Na+ balance in neonatal and adult life. Using in situ hybridization, we localized α-, β-, and γ-rat ENaC (rENaC) mRNA in developing rat kidney and uroepithelia. rENaC mRNA was first detectable on fetal day 16, and by fetal day 17, mRNA was abundant in the terminal collecting duct and uroepithelia. After birth, the intensity of the signals for all three subunits increased in the cortical collecting ducts and by 9 days after birth had diminished in the inner medullary collecting ducts. Expression in uroepithelial cells was different. mRNA for β- and γ-rENaC, but not α-rENaC, was detected in pelvis, ureters, and bladder at all stages of development beyond fetal day 16. By RNase protection assay (RPA), the greatest increase in subunit abundance in the kidney occurred before birth. Between postnatal days 9 and 30, the abundance of β- and γ-rENaC decreased relative to α-rENaC in outer and inner medulla. The urinary bladder, in contrast, demonstrated the greatest increase in β- and γ-rENaC mRNA abundance after birth. We were generally unable to detect α-rENaC by RPA in urinary bladder. Feeding weaned rats a diet of high or low NaCl did not change the abundance of any of the subunit mRNAs in bladder. These results demonstrate additional heterogeneity of developmental expression and regulation of ENaC. The differences between the collecting duct and uroepithelial cell rENaC mRNA regulation raise the possibility of significant differences in function.

APA, Harvard, Vancouver, ISO, and other styles

39

Dixit, Anant, Julien Claudot, Sébastien Lebègue, and Dario Rocca. "Improving the Efficiency of Beyond-RPA Methods within the Dielectric Matrix Formulation: Algorithms and Applications to the A24 and S22 Test Sets." Journal of Chemical Theory and Computation 13, no. 11 (November 2, 2017): 5432–42. http://dx.doi.org/10.1021/acs.jctc.7b00837.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

REINHOLZ, H., T. RAITZA, G. RÖPKE, and I. V. MOROZOV. "OPTICAL AND TRANSPORT PROPERTIES IN DENSE PLASMAS COLLISION FREQUENCY FROM BULK TO CLUSTER." International Journal of Modern Physics B 22, no. 25n26 (October 20, 2008): 4627–41. http://dx.doi.org/10.1142/s0217979208050383.

Full text

Abstract:

The dielectric function of dense plasmas is treated within a many-particle linear response theory beyond the RPA. In the long-wavelength limit, the dynamical collision frequency can be introduced which is expressed in terms of momentum and force auto-correlation functions (ACF). Analytical expressions for the collision frequency are considered for bulk plasmas, and reasonable agreement with MD simulations is found. Different applications such as Thomson scattering, reflectivity, electric and magnetic transport properties are discussed. In particular, experimental results for the static conductivity of inert gas plasmas are now well described. The transition from bulk properties to finite cluster properties is of particular interest. Within semiclassical MD simulations, single-time characteristics as well as two-time correlation functions are evaluated and analyzed. In particular, the Laplace transform of current and force ACFs show typical structures which are interpreted as collective modes of the microplasma. The damping rates of these modes are size dependent. They increase for the transition from small clusters to bulk plasmas.

APA, Harvard, Vancouver, ISO, and other styles

41

Blumenthal, Deborah T., Minhee Won, Minesh P. Mehta, Walter J. Curran, Luis Souhami, Jeff M. Michalski, C. Leland Rogers, and Benjamin W. Corn. "Short Delay in Initiation of Radiotherapy May Not Affect Outcome of Patients With Glioblastoma: A Secondary Analysis From the Radiation Therapy Oncology Group Database." Journal of Clinical Oncology 27, no. 5 (February 10, 2009): 733–39. http://dx.doi.org/10.1200/jco.2008.18.9035.

Full text

Abstract:

Purpose To analyze the Radiation Therapy Oncology Group (RTOG) database of patients with glioblastoma and appraise whether outcome was influenced by time to initiation of radiation therapy (RT). Patients and Methods From 1974 through 2003, adult patients with histologically confirmed supratentorial glioblastoma were enrolled onto 16 RTOG studies. Of 3,052 enrolled patients, 197 patients (6%) were either initially rendered ineligible or had insufficient chronologic data, leaving a cohort of 2,855 patients for the present analysis. We selected four patient groups based on the interval from surgery to the start of RT: ≤ 2 weeks, 2 to 3 weeks, 3 to 4 weeks, more than 4 weeks to the protocol eligibility limit of 6 weeks. Survival times were estimated by the Kaplan-Meier method. Multivariate analysis incorporated variables of time interval, recursive partitioning analysis (RPA) class, and treatment regimen. Results No decrement in survival could be identified with increasing time to initiation of RT. Among our four temporal groupings, median survival time was unexpectedly and significantly greater in the group with the longest interval (> 4 weeks) than in those with the shortest delay (≤ 2 weeks): respectively, 12.5 months versus 9.2 months (P < .0001). On multivariate analysis, with overall survival as the end point, time interval more than 4 weeks and lower RPA class were both significant predictors of improved outcome. Treatment regimen was not a significant factor. Conclusion There is no evident reduction in survival by delaying initiation of RT within the relatively narrow constraint of 6 weeks. An unanticipated yet significantly superior outcome was identified for patients for whom RT was delayed beyond 4 weeks from surgery.

APA, Harvard, Vancouver, ISO, and other styles

42

Ellis, Kris, and Iryna Borshchova. "Towards a Quantitative Approach for Determining DAA System Risk Ratio." Drones 7, no. 2 (February 10, 2023): 127. http://dx.doi.org/10.3390/drones7020127.

Full text

Abstract:

Specific Operations Risk Assessment (SORA) is a methodology developed by the Joint Authority on Rulemaking for Unmanned Systems (JARUS) for safely conducting and evaluating Remotely Piloted Aircraft Systems (RPAS) operations in specific airspace. Many regulators, including Transport Canada (TC), the civilian aviation authority in Canada, have adopted the SORA approach to guide RPAS operators in their applications for Beyond Visual Line of Sight (BVLOS) flight. Although the qualitative approach on how to assess the performance of a Detect and Avoid (DAA) system is outlined in the SORA, a quantitative and agreed-upon approach, on how to ensure that the specific DAA system meets the required Risk Ratio criteria, has yet to be established. This paper proposes a practical approach to determining the Risk Ratio, considering sensor performance, RPA maneuvering characteristics, and airspace specifics. The developed approach relies on publicly available modelling frameworks and airspace models. Illustrative examples of applying the method to determine the Risk Ratio of specific DAA systems are presented in the paper along with a discussion on the challenges of implementing SORA into BVLOS regulations for RPAS.

APA, Harvard, Vancouver, ISO, and other styles

43

Murphy, Colin T., Thomas J. Galloway, Elizabeth A. Handorf, Brian L. Egleston, Lora S. Wang, Ranee Mehra, Douglas B. Flieder, and John A. Ridge. "Survival Impact of Increasing Time to Treatment Initiation for Patients With Head and Neck Cancer in the United States." Journal of Clinical Oncology 34, no. 2 (January 10, 2016): 169–78. http://dx.doi.org/10.1200/jco.2015.61.5906.

Full text

Abstract:

Purpose To estimate the overall survival (OS) impact from increasing time to treatment initiation (TTI) for patients with head and neck squamous cell carcinoma (HNSCC). Methods Using the National Cancer Data Base (NCDB), we examined patients who received curative therapy for the following sites: oral tongue, oropharynx, larynx, and hypopharynx. TTI was the number of days from diagnosis to initiation of curative treatment. The effect of TTI on OS was determined by using Cox regression models (MVA). Recursive partitioning analysis (RPA) identified TTI thresholds via conditional inference trees to estimate the greatest differences in OS on the basis of randomly selected training and validation sets, and repeated this 1,000 times to ensure robustness of TTI thresholds. Results A total of 51,655 patients were included. On MVA, TTI of 61 to 90 days versus less than 30 days (hazard ratio [HR], 1.13; 95% CI, 1.08 to 1.19) independently increased mortality risk. TTI of 67 days appeared as the optimal threshold on the training RPA, statistical significance was confirmed in the validation set (P < .001), and the 67-day TTI was the optimal threshold in 54% of repeated simulations. Overall, 96% of simulations validated two optimal TTI thresholds, with ranges of 46 to 52 days and 62 to 67 days. The median OS for TTI of 46 to 52 days or fewer versus 53 to 67 days versus greater than 67 days was 71.9 months (95% CI, 70.3 to 73.5 months) versus 61 months (95% CI, 57 to 66.1 months) versus 46.6 months (95% CI, 42.8 to 50.7 months), respectively (P < .001). In the most recent year with available data (2011), 25% of patients had TTI of greater than 46 days. Conclusion TTI independently affects survival. One in four patients experienced treatment delay. TTI of greater than 46 to 52 days introduced an increased risk of death that was most consistently detrimental beyond 60 days. Prolonged TTI is currently affecting survival.

APA, Harvard, Vancouver, ISO, and other styles

44

Orsburn, Benjamin, Beatriz Escudero, Mansi Prakash, Silvia Gesheva, Guosheng Liu, David L. Huso, and Sonia Franco. "Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1." Molecular and Cellular Biology 30, no. 10 (March 15, 2010): 2341–52. http://dx.doi.org/10.1128/mcb.00091-10.

Full text

Abstract:

ABSTRACT Combined deficiencies of poly(ADP)ribosyl polymerase 1 (PARP1) and ataxia telangiectasia mutated (ATM) result in synthetic lethality and, in the mouse, early embryonic death. Here, we investigated the genetic requirements for this lethality via analysis of mice deficient for PARP1 and either of two ATM-regulated DNA damage response (DDR) factors: histone H2AX and 53BP1. We found that, like ATM, H2AX is essential for viability in a PARP1-deficient background. In contrast, deficiency for 53BP1 modestly exacerbates phenotypes of growth retardation, genomic instability, and organismal radiosensitivity observed in PARP1-deficient mice. To gain mechanistic insights into these different phenotypes, we examined roles for 53BP1 in the repair of replication-associated double-strand breaks (DSBs) in several cellular contexts. We show that 53BP1 is required for DNA-PKcs-dependent repair of hydroxyurea (HU)-induced DSBs but dispensable for RPA/RAD51-dependent DSB repair in the same setting. Moreover, repair of mitomycin C (MMC)-induced DSBs and sister chromatid exchanges (SCEs), two RAD51-dependent processes, are 53BP1 independent. Overall, our findings define 53BP1 as a main facilitator of nonhomologous end joining (NHEJ) during the S phase of the cell cycle, beyond highly specialized lymphocyte rearrangements. These findings have important implications for our understanding of the mechanisms whereby ATM-regulated DDR prevents human aging and cancer.

APA, Harvard, Vancouver, ISO, and other styles

45

Fan, J. D., and Y. M. Malozovsky. "The Role of the Coulomb Interaction in Superconductivity." International Journal of Modern Physics B 12, no. 29n31 (December 20, 1998): 2906–13. http://dx.doi.org/10.1142/s0217979298001769.

Full text

Abstract:

It is found that particle pairing is nothing else but grouping in the statistical sense and that only in the particle–hole channel does the BCS Hamiltonian have the BCS solution for an attractive interaction, whereas the interaction in the particle–particle channel is still repulsive. A generalized perturbation approach beyond the random phase approximation (RPA), based on Ward's identity, was developed by the authors to deal with both weakly and strongly coupled electronic systems. The full summation of all of the possible Feynman diagrams of two-particle interaction guarantees its validity. A phase transition in this method is determined by instability of the normal state, often referred to as the pairing instability, but better to resonance of interaction, equivalent to the pole condition in the two-particle scattering amplitude. Of more importance and interest is that superconductivity, regardless of low or high temperature, is found to originate from the Coulomb correlations. It was shown that only if interaction in the particle–particle channel is repulsive may the instability occur and the irreducible response function, hence conductivity, tends to infinity as temperature approaches T c . The transition temperature T c is found to be related to the physical, chemical and structural parameters, such as the dielectric constant, concentration of carriers and interlayer spacing. Therefore, low- and high-temperature superconductivity do not have an intrinsic distinction but their observed different properties. An application of the approach to a layered two-dimensional system immediately leads to the metal–superconductor (MS) transition with a possible high transition temperature, while the MS transition in an isotropic three-dimensional system can never exhibit a high transition temperature.

APA, Harvard, Vancouver, ISO, and other styles

46

Marcos, Alfredo. "Virtue Ethics Beyond Fashions." Revista Portuguesa de Filosofia 76, no. 1 (April 30, 2020): 25–48. http://dx.doi.org/10.17990/rpf/2020_76_1_0025.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Sonmez, Cagla, and Caroline Dean. "Transcription beyond borders has downstream consequences." RNA Biology 9, no. 2 (February 2012): 143–47. http://dx.doi.org/10.4161/rna.18668.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Hughes, H. G. "Uncertainties beyond statistics in Monte Carlo simulations." Radiation Protection Dosimetry 126, no. 1-4 (May 13, 2007): 45–51. http://dx.doi.org/10.1093/rpd/ncm011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Eicher-Catt, Deborah. "Being Made Strange: Rhetoric Beyond Representation (review)." Rhetoric & Public Affairs 9, no. 2 (2006): 328–31. http://dx.doi.org/10.1353/rap.2006.0040.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Weinstein, Susanna J. "Rhetoric Before and Beyond the Greeks (review)." Rhetoric & Public Affairs 9, no. 2 (2006): 321–24. http://dx.doi.org/10.1353/rap.2006.0065.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Beyond RPA'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles