Academic literature on the topic 'Beta-cell secretion'
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Journal articles on the topic "Beta-cell secretion"
Kim, P. H., and M. F. Kagnoff. "Transforming growth factor beta 1 increases IgA isotype switching at the clonal level." Journal of Immunology 145, no. 11 (December 1, 1990): 3773–78. http://dx.doi.org/10.4049/jimmunol.145.11.3773.
Full textRoldán, E., C. Rodriguez, G. Navas, C. Parra, and J. A. Brieva. "Cytokine network regulating terminal maturation of human bone marrow B cells capable of spontaneous and high rate Ig secretion in vitro." Journal of Immunology 149, no. 7 (October 1, 1992): 2367–71. http://dx.doi.org/10.4049/jimmunol.149.7.2367.
Full textRastogi, D. P., A. C. Saxena, and Sunil Kumar. "Pancreatic beta-cell regeneration." British Homeopathic Journal 77, no. 03 (July 1988): 147–51. http://dx.doi.org/10.1016/s0007-0785(88)80071-1.
Full textKaratug Kacar, A., S. Gezginci-Oktayoglu, and S. Bolkent. "4-Methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-A in INS-1 beta-cells." Human & Experimental Toxicology 37, no. 11 (February 23, 2018): 1123–30. http://dx.doi.org/10.1177/0960327118758365.
Full textDela, F., K. J. Mikines, B. Tronier, and H. Galbo. "Diminished arginine-stimulated insulin secretion in trained men." Journal of Applied Physiology 69, no. 1 (July 1, 1990): 261–67. http://dx.doi.org/10.1152/jappl.1990.69.1.261.
Full textSjoholm, A. "Nitric oxide donor SIN-1 inhibits insulin release." American Journal of Physiology-Cell Physiology 271, no. 4 (October 1, 1996): C1098—C1102. http://dx.doi.org/10.1152/ajpcell.1996.271.4.c1098.
Full textShcherbina, L., A. Edlund, J. L. S. Esguerra, M. Abels, Y. Zhou, E. Ottosson-Laakso, C. B. Wollheim, O. Hansson, L. Eliasson, and N. Wierup. "Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes." Molecular and Cellular Endocrinology 447 (May 2017): 52–60. http://dx.doi.org/10.1016/j.mce.2017.02.027.
Full textBrüning, Dennis, Kathrin Hatlapatka, Verena Lier-Glaubitz, Vincent Andermark, Stephan Scherneck, Ingo Ott, and Ingo Rustenbeck. "Pharmacological inhibition of thioredoxin reductase increases insulin secretion and diminishes beta cell viability." Naunyn-Schmiedeberg's Archives of Pharmacology 394, no. 6 (January 19, 2021): 1133–42. http://dx.doi.org/10.1007/s00210-020-02046-2.
Full textEhrhardt, R. O., W. Strober, and G. R. Harriman. "Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation." Journal of Immunology 148, no. 12 (June 15, 1992): 3830–36. http://dx.doi.org/10.4049/jimmunol.148.12.3830.
Full textYoung, P. R., D. J. Hazuda, and P. L. Simon. "Human interleukin 1 beta is not secreted from hamster fibroblasts when expressed constitutively from a transfected cDNA." Journal of Cell Biology 107, no. 2 (August 1, 1988): 447–56. http://dx.doi.org/10.1083/jcb.107.2.447.
Full textDissertations / Theses on the topic "Beta-cell secretion"
Flax, Helene. "Regulation of beta-cell secretion in man." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291075.
Full textStokesberry, Susan Anne. "Functional effects of temperature on pancreatic beta-cell insulin secretion and integrity." Thesis, University of Ulster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422895.
Full textOwen, R. A. "The role of transglutaminase in stimulus-secretion coupling in the pancreatic #beta#-cell." Thesis, Nottingham Trent University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384731.
Full textEagle, Laurence Alfanso. "Regulation of Beta-cell tropin secretion from intermediate pituitary of lean and obese mice." Thesis, University of Buckingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601360.
Full textHeister, Paula Maria. "The role of two pore channels (TPCs) in pancreatic beta cell stimulus-secretion coupling." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:4bed27d2-e7e4-49ff-8168-aa02b6f9b613.
Full textCastell, Auví Anna. "The effects of grape seed procyanidin extract on insulin synthesis and secretion." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/79133.
Full textLes procianidines són compostos bioactius presents en fruites i vegetals. Tot i que es coneixen els efectes beneficiosos d’aquests compostos en l’homeòstasi de la glucosa, la seva acció en la funcionalitat de la cèl•lulaβ no és clara. La present tesi doctoral s’ha centrat en descriureels efectes de les procianidines en la síntesi i secreció d’insulina. Els nostres resultats mostren la capacitat de les procianidines de modificar la funcionalitat de la cèl•lula β augmentant la relació insulina plasmàtica/mRNA, tot i que l’efectivitat del tractamentdepèn de la situaciófisiològica. En situacions no patològiques, les procianidines afecten la insulinèmia modificant la síntesi, secreciói/o degradació d’insulina. En situacions de resistència a la insulina, el tractamentcrònicamb procianidines disminueix la síntesi i secreció d’insulina gràcies a la seva acció limitant l’acumulació de lípids. En canvi, en un model més danyat (obesitat genètica), les procianidines exerceixen efectes similars però no son capaces de millorar la hiperinsulinèmia. En conclusió, les procianidines, en les dosis assajades, podenutilitzar-seúnicament coma compostos bioactiuslimitant la disfuncionalitat de la cèl•lula β en els seus estats inicials.
Procyanidins are bioactive compounds found in fruits and vegetables widely consumed. It has been reported that procyanidins show some beneficial effects on glucose homeostasis, although their effects on β-cell functionality remain unresolved. This doctoral thesis is focus on describing the effects of procyanidins on insulin synthesis and secretion. Our results showed that procyanidins modify β-cell functionality through increasing the plasma insulin/mRNA ratio, although the effectiveness of the treatment depends on the physiological situation. Under non-pathological situation, procyanidins affected insulinaemia by modifying insulin synthesis, secretion and/or degradation activity. Under insulin-resistance situation, chronic procyanidins administration decreased insulin synthesis and secretion, thanks to its lipid-lowering effect. Otherwise in a more damaged model, Zucker fatty rat, procyanidins treatment is not able to reduce insulin plasma levels although they repress insulin expression. In conclusion, procyanidins could be used as bioactive compound to limit β-cell dysfunctions under high-palatable diets, but at the assayed doses, it is not enough to counteract a strong metabolic disruption.
Barutcu, Seda. "Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/954.
Full textTurbitt, Julie Michelle. "The role of taurine in the regulation of insulin secretion and pancreatic beta-cell function." Thesis, University of Ulster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422896.
Full textIdevall, Hagren Olof. "Oscillatory Signaling and Insulin Secretion from Single ß-cells." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113686.
Full textHerrero, Rodríguez Laura. "Implication of Long-Chain Fatty Acids in Glucose-Induced Insulin Secretion in the Pancreatic Beta-Cell." Doctoral thesis, Universitat de Barcelona, 2004. http://hdl.handle.net/10803/2999.
Full textOBJECTIVES 1) Study of the malonyl-CoA/CPTI interaction in the pancreatic Beta-cell and its involvement in glucose-stimulated insulin secretion (GSIS). 2) Construction of an INS stable cell line overexpressing LCPTI wt and LCPTI M593S. 3) Determine the effect of C75 on the CPTI activity and palmitate oxidation in pancreatic Beta-cells.
RESULTS. In Ad-LCPTI M593S infected INS(832/13) cells LCPTI activity increased six-fold. This was associated with enhanced fatty acid oxidation, at any glucose concentration, and a 60% suppression of GSIS. In isolated rat islets in which LCPTI M593S was overexpressed, GSIS decreased 40%. At high glucose concentration, overexpression of LCPTI M593S reduced partitioning of exogenous palmitate into lipid esterification products, and decreased PKC activation. Moreover, LCPTI M593S expression impaired KATP channel-independent GSIS in INS(832/13) cells.
INS-1 stable clones of LCPTIwt and LCPTImut were constructed, however none of them resulted in an increase in LCPTI protein expression compared to endogenous LCPTI nor in CPTI activity. Therefore, slight basal overexpression of LCPTI could probably be toxic for the cells, as a result of which only those cells that do not contain the LCPTI plasmids survived throughout cell passages.
When INS(823/13) cells are incubated with C75, CPTI activity is inhibited, as is fatty acid oxidation. In vivo, a single intraperitoneal injection of C75 to mice produces a short-term inhibition of CPTI activity in mitochondria from liver and pancreas.
DISCUSSION. The results with LCPTImut provide direct support for the hypothesis proposing that the malonyl-CoA/CPTI interaction is a component of a metabolic signalling network that controls insulin secretion. Overall, the findings with C75 provide compelling evidence that the drug is a potent inhibitor of CPTI.
Books on the topic "Beta-cell secretion"
Susumu, Seino, and Bell Graeme, eds. Pancreatic beta cell in health and disease. [Tokyo]: Springer, 2008.
Find full textKulkarni, Rohit N. Islet cell growth factors. Austin, Tex: Landes Bioscience, 2011.
Find full textD, Huizinga Jan, ed. Pacemaker activity and intercellular communication. Boca Raton: CRC Press, 1995.
Find full textLiu, Hui-Kang. Modification of the function of insulin-secreting cells by beta-cell toxins, differentiation drugs, insulin mimetics, steriods, and incretin hormones and their stable analogues. [S.l: The Author], 2003.
Find full textJoseph, Jamie W. beta-cell stimulus-secretion coupling: A role for uncoupling protein 2. 2004.
Find full textKashyap, Sangeeta. Medical Management of Endocrine Disorders after Bariatric Surgery. Edited by Tomasz Rogula, Philip Schauer, and Tammy Fouse. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190608347.003.0015.
Full textSeino, Susumu, and Graeme I. Bell. Pancreatic Beta Cell in Health and Disease. Springer, 2009.
Find full textIslet Transplantation and Beta Cell Replacement Therapy. Informa Healthcare, 2007.
Find full textShapiro, A. M. James, and James A. M. Shaw. Islet Transplantation and Beta Cell Replacement Therapy. Taylor & Francis Group, 2007.
Find full textShapiro, A. M. James, and James A. M. Shaw. Islet Transplantation and Beta Cell Replacement Therapy. Taylor & Francis Group, 2007.
Find full textBook chapters on the topic "Beta-cell secretion"
Willenborg, Michael, Kirstin Schumacher, and Ingo Rustenbeck. "Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets." In Animal Models in Diabetes Research, 189–201. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-068-7_12.
Full textLahiri, Debomoy K., and Martin R. Farlow. "Tacrine Reduces the Secretion of Soluble Amyloid Beta-Peptides in a Neuroblastoma Cell Line." In Advances in Behavioral Biology, 563–69. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5337-3_80.
Full textBoyd, A. E., R. S. Hill, T. Y. Nelson, J. M. Oberwetter, and M. Berg. "The Role of Cytosolic Calcium in Insulin Secretion from a Hamster Beta Cell Line." In Advances in Experimental Medicine and Biology, 305–16. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5314-0_27.
Full textKeane, Kevin, and Philip Newsholme. "Metabolic Regulation of Insulin Secretion." In The Pancreatic Beta Cell, 1–33. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-800174-5.00001-6.
Full textGroschner, Lukas N., Muhammad Rizwan Alam, and Wolfgang F. Graier. "Metabolism–Secretion Coupling and Mitochondrial Calcium Activities in Clonal Pancreatic β-Cells." In The Pancreatic Beta Cell, 63–86. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-800174-5.00003-x.
Full textJacobsen, Maria Louise Brings, Christine Bruun, Lena Eliasson, Thomas Mandrup-Poulsen, and Nils Billestrup. "Bone Morphogenetic Protein 4 Inhibits Insulin Secretion in Rat Islets." In BASIC/TRANSLATIONAL - Beta Cell Biology, P2–485—P2–485. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part3.p5.p2-485.
Full textLee, Jeongkyung, Mi-sun Kim, Rongying Li, Victoria Liu, Zhe Fang, David L. Nelson, Loning Fu, David D. Moore, Ke Ma, and Vijay K. Yechoor. "Bmal1 Is Required for Normal β-Cell Mitochondrial Energy Metabolism and Insulin Secretion." In BASIC/TRANSLATIONAL - Beta Cell Biology, P2–489—P2–489. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part3.p5.p2-489.
Full textKim, Wook, Zhuo Liu, Maire E. Doyle, Yu-Kyong Shin, Olga D. Carlson, Jennifer Fiori, Shekhar Gadkaree, Eun Kyung Lee, Qi Zong Lao, and Josephine M. Egan. "Cannabinoid 1 Receptor Blockade Improves Incretin-Mediated Insulin Secretion in Pancreatic Beta Cells." In BASIC/TRANSLATIONAL - Beta Cell Biology, OR01–4—OR01–4. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part1.or2.or01-4.
Full textAl-Romaiyan, Altaf, Bo Liu, Guo-Cai Huang, Stephanie Amiel, Shanta Persaud, and Peter Jones. "Extracellular Ca2+and Protein Kinases Play Important Roles in MediatingGymnema sylvestre-Induced Insulin Secretion from Mouse and Human Islets." In BASIC/TRANSLATIONAL - Beta Cell Biology, P2–477—P2–477. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part3.p5.p2-477.
Full textLeoni, Martina, Nathalia Padilla, Andrea Fabbri, David Della-Morte, Camillo Ricordi, and Marco Infante. "Mechanisms of Insulin Resistance during Pregnancy." In Evolving Concepts in Insulin Resistance [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.107907.
Full textConference papers on the topic "Beta-cell secretion"
Tura, Andrea, Manfred Hecking, Michael Wolzt, Marcus D. Saemann, and Giovanni Pacini. "Assessment of beta-cell function and insulin secretion in subjects that underwent renal transplantation." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7318870.
Full textGaus, B., and I. Rustenbeck. "Insulin granule number, mobility and exocytosis as compared with insulin content and secretion after the induction of desensitization or beta-cell rest." In Diabetes Kongress 2021 – 55. Jahrestagung der DDG. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1727355.
Full textSaksela, O., D. Moscatelli, and D. B. Rifkin. "THE OPPOSING OF BASIC FIBROBLAST GROWTH FACTOR AND TRANSFORMING GROWTH FACTOR BETA ON THE REGULATION OF PLASMINOGEN ACTIVATOR ACTIVITY IN CAPILLARY ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644660.
Full textLibby, Peter, Stephen J. C. Warner, and Louis K. Birinyi. "THE VESSEL WALL AS A SOURCE OF VASORHGOLATORY AND IMMDNOSTIMOLATORY CYTOKINES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643982.
Full textSelak, M. A., M. Chignard, and J. B. Smith. "CHARACTERIZATION OF A NEUTROPHIL CPYMOTRYPSIN-LIKE ENZYME THAT ACTIVATES PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643157.
Full textReports on the topic "Beta-cell secretion"
Elmann, Anat, Orly Lazarov, Joel Kashman, and Rivka Ofir. therapeutic potential of a desert plant and its active compounds for Alzheimer's Disease. United States Department of Agriculture, March 2015. http://dx.doi.org/10.32747/2015.7597913.bard.
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