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Dissertations / Theses on the topic 'Benzodiazepine'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

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1

Rizzo, Michael L. "The Prescribing Knowledge, Attitudes, and Practices among Nurse Practitioners in Maine towards Benzodiazepines." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/RizzoML2004.pdf.

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2

Kavvadias, Dominique. "Liganden des Benzodiazepin-Rezeptors Studien über Benzodiazepine in pflanzlichen Geweben sowie über Hispidulin /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969716087.

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3

Fluck, Emma Jane. "Benzodiazepine modulation of human memory." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300711.

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4

Elliot, Elizabeth. "Benzodiazepine tolerance and withdrawal quantified using radiotelemetry /." Title page, abstract and contents only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phe461.pdf.

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5

Diorio, Diane Lynn. "Peripheral benzodiazepine binding sites in psychiatric disorders." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55676.

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6

Bilbe, Graeme. "Molecular studies on the gaba-benzodiazepine receptor." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37639.

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7

SEROR, PAULE-MICHELE. "Les antagonistes des benzodiazepines." Lyon 1, 1989. http://www.theses.fr/1989LYO1M257.

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8

Guenoux, Charles-Albert. "Benzodiazepines : aspects pharmacologiques actuels." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20952.

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9

NICOLAI, LAURENT. "Effets amnesiants des benzodiazepines." Strasbourg 1, 1992. http://www.theses.fr/1992STR15003.

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10

MALOGNE, HERVE. "La toxicite hepatique des benzodiazepines." Amiens, 1993. http://www.theses.fr/1993AMIEM013.

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11

MOUSSY, HUBERT CORINNE. "Etudes psychometriques des benzodiazepines." Nantes, 1992. http://www.theses.fr/1992NANT042M.

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12

Barbut, Frédéric. "Les récepteurs des benzodiazépines." Paris 5, 1988. http://www.theses.fr/1988PA05P169.

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13

Mphahlele, Malose Jack. "Synthetic and spectroscopic studies of 1,4-benzodiazepine analogues." Thesis, Rhodes University, 1994. http://hdl.handle.net/10962/d1005049.

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In this project, an extensive range of benzodiazepine analogues have been synthesised via Schmidt reaction of specially prepared flavanone, 4-quinolone and l-thioflavanone precursors; nitrogen insertion being effected by use of trimethylsilyl azide in trifluoroacetic acid. In some cases, several of the benzodiazepine analogues have also been prepared by alternative cyclisation routes. A detailed kinetic-mechanistic study of the Schmidt reaction of flavanones has been carried out using 'H NMR spectroscopy to explain the observed regiochemistry of nitrogen insertion. The reaction rates, for the formation of both amide and tetrazolo derivatives have been found to be influenced by the electronic effects of the A- and B-ring substituents. A series of benzodiazepine analogues have been shown to undergo regioselective A-ring chlorination with t-butylhypochlorite; the products being characterised by 'H NMR, IR and mass spectroscopy. The mass spectrometric fragmentation patterns of series of 2-aryl-4-quinolones, and 2-aryl-l ,4-benzodiazepinones and their tetrazolo[l ,5-dl analogues have been elucidated using a combination of low-resolution, high-resolution and metastable-peak analyses. The binding affinities of various benzodiazepine analogues for rat brain benzodiazepine receptors have been evaluated using a radioreceptor assay technique. Structure-activity relationships were investigated to establish the effects of various A-, B- and Coring substituents on binding affinity. The conformational preferences of selected systems have been studied using a combination of multi-pulse 'H NMR spectroscopy, X-ray crystallography and computer modelling techniques with a view to establishing the influence of conformation on binding affinity.

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14

Vorma, Helena. "Benzodiazepine discontinuation treatment in outpatients with complicated dependence." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/vorma/.

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15

DEFOUR, ERIC. "Reactions cutanees aux benzodiazepines." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR1M132.

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16

STITI, SALADIN. "Les benzodiazepines et leurs paradoxes." Toulouse 3, 1988. http://www.theses.fr/1988TOU31061.

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17

GAGET, YVES. "Les hepatites dues aux benzodiazepines." Nice, 1992. http://www.theses.fr/1992NICE6535.

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18

MOLLON, PATRICK. "Les intoxications aigues par flunitrazepam, loflazepate d'ethyle, prazepam : etude retrospective de 2 000 dossiers du centre anti-poisons de lyon." Lyon 1, 1990. http://www.theses.fr/1990LYO1M097.

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19

AZOULAY, CORINNE. "Les intoxications aigues par benzodiazepines : a propos de 284 observations recueillies par le samu de lyon." Lyon 1, 1989. http://www.theses.fr/1989LYO1M056.

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20

Roujansky, Pierre. "Etude de la tolerance aux effets anti-epileptiques des benzodiazepines : revue de la litterature et contribution personnelle." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M135.

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21

Xu, Zhiwen. "Topology characterization of a benzodiazepine-binding domain of GABAA receptor and anxiolytic-like effect of baicalin acting through the benzodiazepine-binding site /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BICH%202005%20XUZ.

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Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2005.
On t.p. final "A" of GABAA is subscript. Includes bibliographical references (leaves 148-167). Also available in electronic version.

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22

NOEUVEGLISE, ERIC. "Embryofoetopathie par benzodiazepines : une entite ?" Lille 2, 1994. http://www.theses.fr/1994LIL2M100.

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23

Lyne, John Peter. "Enhancement of cognitive and psychomotor recovery following benzodiazepine sedation." Thesis, University of Newcastle upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421179.

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24

McAdam, Laura Catherine. "Propofol and benzodiazepine modulation of GABA[subscript]AR function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0013/MQ29345.pdf.

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25

Al-Nawar, Karim FrancÌ§ois. "Synthesis of novel benzothiazine and benzodiazepine-1,1-dioxide derivatives." Thesis, University of Hertfordshire, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431933.

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26

Kapczinski, Flavio. "A psychopharmacological investigation of the benzodiazepine receptor in humans." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307685.

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27

Gerrish, Kevin Edward 1965. "Modulation of Nb2 cell mitogenesis by peripheral benzodiazepine ligands." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277200.

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In this study, we investigated the effects of the peripheral benzodiazepine ligands, Ro5-4864 (putative antagonist) and PK 11195 (putative antagonist) on prolactin stimulated mitogenesis in Nb2 cells. Ro5-4864 and PK 11195 at 10⁻⁹ M maximally enhanced prolactin stimulated mitogenesis. At 10⁻⁶ M Ro5-4864 inhibited prolactin stimulated mitogenesis. Clonazepam, a ligand for the central benzodiazepine receptor had no effect on mitogenesis. Interaction studies were undertaken to determine if Ro5-4864 and PK 11195 act on the same site. The ability of each ligand to enhance the mitogenic action of prolactin was blocked by a 10⁻⁶ M concentration of the other ligand. Finally, simultaneous addition of 10⁻⁹ M of the ligands resulted in no additive effect over each ligand alone. These data show that peripheral benzodiazepine ligands modulate prolactin-stimulated mitogenesis and suggests they interact at the same binding site.

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28

BACHERT, BLANC CATHY. "Pharmacodependance aux benzodiazepines et syndrome de sevrage." Lille 2, 1991. http://www.theses.fr/1991LIL2P069.

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29

COISSARD, ANNE-NADINE. "Benzodiazepines et grossesse : complications neonatales." Lyon 1, 1993. http://www.theses.fr/1993LYO1M193.

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30

Jonot, André. "Les benzodiazepines : usage, abus et intoxications." Université Louis Pasteur (Strasbourg) (1971-2008), 1990. http://www.theses.fr/1990STR1M117.

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31

Fernandes, Catherine. "Factors influencing the development of diazepam dependence in the rat." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339194.

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32

SEBILLE, RAFFALLI MARIE-JOSEPHINE. "Etude des recepteurs des benzodiazepines chez l'homme normal et le suicide." Lyon 1, 1989. http://www.theses.fr/1989LYO1M110.

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33

GUILLEMOT, FRANCOISE. "Le syndrome de sevrage en benzodiazepines : a propos de 21 observations." Lyon 1, 1993. http://www.theses.fr/1993LYO1M173.

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34

Joffre, Thierry. "Utilisation du flumazenil (anexate*) dans les intoxications medicamenteuses aigues volontaires par benzodiazepines seules ou associees a d'autres toxiques : a propos d'une etude retrospective de 326 cas hospitalises au service n 1 de l'hopital edouard herriot de 1988 a 1990." Lyon 1, 1992. http://www.theses.fr/1992LYO1M104.

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35

PISANO, CREVAT PASCALE. "Apport du radiorecepteur-essai a la pharmacologie clinique des benzodiazepines." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX22957.

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36

Giersch, Anne. "Effets d'une prise unique de lorazepam, une benzodiazepine, sur les processus visuo-perceptifs chez le volontaire sain." Strasbourg 1, 1997. http://www.theses.fr/1997STR15027.

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37

JOURDAIN, FLORENCE. "Etudes de teratogenese des benzodiazepines chez l'animal et risques au cours de la grossesse." Strasbourg 1, 1995. http://www.theses.fr/1995STR15003.

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38

Drelon, Florence. "Intérêt du flumazénil (anexate R) dans les intoxications aiguës par benzodiazépines chez l'adulte : à propos d'une série de 162 cas." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR1M009.

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39

Vincent, N. D. A. "The changes in GABA and benzodiazepine biochemistry following seizure states." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370306.

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40

Cormack, M. A. "Psychological alternatives to long-term benzodiazepine use in general practice." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234848.

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41

Shen, Guofu. "Bidirectional Regulation of AMPA and NMDA Receptors during Benzodiazepine Withdrawal." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1242680312.

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42

Corley, Elizabeth. "Physician Training and Support in Managing Dilemmas Around Benzodiazepine Prescribing." Antioch University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1608072345882436.

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43

Parola, Anthony Lawrence. "Pharmacological and molecular heterogeneity of the "peripheral-type benzodiazepine receptor"." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185185.

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The rat liver peripheral-type benzodiazepine receptor (PBR) was characterized by ligand binding with [³H]Ro5-4864 and by photolabeling using [³H]PK 14105. The native liver receptor could be solubilized with digitonin. The Mr of the native photolabeled receptor was 170 kDa while a single Mr 19 kDa protein was identified under denaturing conditions. Radioligand binding to rat liver subcellular fractions showed protoporphyrin IX had a 6.2-fold greater affinity for [³H]Ro5-4864 binding sites in mitochondria than in microsomes. Although heterogeneity of the rat liver benzodiazepine binding site, but not the isoquinoline binding site, was observed, a single 19 kDa protein band was identified by photolabeling with an isoquinoline ligand. Bovine and rat PBR have a similar tissue and subcellular distribution, but are pharmacologically and biochemically distinct. The bovine PBR had low affinity for Ro5-4864 and diazepam while [³H]PK 11195 binding was insensitive to modification of histidine residues. The native Mr the receptor was 200 kDa by gel filtration. Photolabeling identified a 17 kDa protein from both rat and bovine adrenal mitochondria under denaturing conditions. An affinity matrix was constructed to purify the native components of the PBR from both species, but the PBR could not be eluted from the matrix. To compare receptor components, the cDNA encoding the rat isoquinoline binding protein was used to screen a fetal calf adrenal cDNA library. A 822 base pair bovine cDNA was identified that encoded a polypeptide of 169 amino acids which had 78% positional identity to the rat protein and was 97% similar after accounting for conserved replacements. Comparison of the amino acid sequences indicates the rat and bovine proteins are homologs and the species differences in ligand binding may not be due to differences in the primary sequence of the isoquionoline binding proteins. Our results indicate the common characteristics of PBR is their ability to bind isoquinoline ligands, not benzodiazepine ligands, with high affinity. A conserved 17-19 kDa protein is required for demonstration of this receptor. A new nomenclature is presented which designates these receptors as τ (tau) receptors.

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44

Witt, Anette. "Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-077-6/.

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45

NEYMEYER, NATHALIE. "Benzodiazepines et induction de l'anesthesie." Strasbourg 1, 1987. http://www.theses.fr/1987STR10709.

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46

Bartlett-Esquilant, Gillian. "Patterns of benzodiazepine use and risk of injury in the elderly." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37869.

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Background. Benzodiazepines are sedative-hypnotic medications frequently prescribed in elderly patients for several clinical indications. An association with increased risk for falls has been reported but there is continued debate regarding which specific benzodiazepines are associated with this risk.
Objectives. To estimate the risk of injuries from falls associated with benzodiazepine use in an elderly cohort taking into account patient characteristics and changes in patterns of use over time.
Methods. Using information from provincial administrative health databases, 462,543 community-dwelling, 66 year old Quebec residents were screened for benzodiazepine use in 1989. Subjects who did not use benzodiazepines in 1989 were observed for the next five years to estimate incidence rates and evaluate patient characteristics associated with new use for thirteen benzodiazepines. Patterns of use for incident users were characterized in terms of duration, dose and frequency of switching or adding benzodiazepines. New methods were developed to model the past cumulative dose and duration of benzodiazepine exposure. The impact of benzodiazepine exposure on risk of injury was estimated using Cox proportional hazards analyses with time-dependent covariates to take into account changes in dose and patterns of use.
Results. The overall incidence rate for benzodiazepines was 88.7 per 1,000 person-years, with higher rates in women (95.0) than men (81.8). Predictors of incident use were different in individual products and there were systematic differences between users and non-users. Use of anti-depressants in 1989 was the strongest predictor for incident benzodiazepine use (HR 1.45 to 3.07, p < 0.0001). The median duration for uninterrupted periods of use was 31 days (mean = 75.5 days, sd = 137.2). The mean dose was almost half the recommended maximum adult daily dose and only 8.6% of subjects exceeded the maximum. Older age at date of first prescription significantly increased the likelihood of increasing duration and dose overtime (OR = 1.02, p < 0.0001). All benzodiazepines except clonazeparn were significantly associated with an increased risk of injuries from falls (p < 0.05). The best predictive model for most benzodiazepines included a cumulative measure of duration and current dose.
Conclusion. Benzodiazepines are associated with an increased risk of injuries from falls in elderly patients, however duration of exposure may be more critical than dose. Physiological dependence and withdrawal symptoms appear to play an important role in increasing the risk for many benzodiazepines.

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47

Higgs, Suzanne. "Benzodiazepine receptors and the control of ingestive behaviour in the rat." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5441/.

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When administered systemically, benzodiazepine receptor agonists have been shown to increase food intake in a number of species. Conversely, benzodiazepine receptor inverse agonists bring about reliable decreases in feeding. The aim of the experiments reported in this thesis was to investigate the brain and behavioural mechanisms involved in the effects of benzodiazepines on ingestion. The effect on food intake of microinjection of the benzodiazepine receptor agonist midazolam into the brainstem of the rat was investigated. A reliable hyperphagic response was elicited following injection of midazolam into both the IVth ventricle and the parabrachial nucleus (PEN). This increase in intake was reversed by pretreatment with the selective benzodiazepine receptor antagonist flumazenil. These results suggest that benzodiazepine receptors located in the brainstem, specifically in the PEN, may be responsible for the effects of benzodiazepines on ingestion. In further experiments, a microstructural approach was adopted which involved analyzing the effects of benzodiazepine ligands on the detailed pattern of licking for both a carbohydrate and a fat in the rat. The effects of midazolam were similar to the effects of increasing concentration. The effects of the benzodiazepine receptor inverse agonist Ro 15-4513 were similar to the effects of decreasing concentration. These results suggest that benzodiazepines influence ingestive behaviour by modulating palatability. The proposal that benzodiazepines may interact with opioids to influence feeding behaviour was examined in Chapters 7 and 8. Although the effects of the opioid agonist morphine and the opioid antagonist naloxone on licking behaviour were not the same as the effects of benzodiazepine ligands, naloxone blocked the effects of midazolam. These results suggest that the effects of benzodiazepine on palatability may depend on release of endogenous opioid peptides. This work has implications for understanding the neural control of ingestive behaviour and may help in developing new therapies for clinical disorders such as anorexia and bulimia.

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48

Norton, Royan. "The effects of nicotine, benzodiazepine and mood on electro-cortical activity." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336007.

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49

Kirkness, E. F. "The #gamma#-aminobutyrate/benzodiazepine receptor from pig brain : Purification and characterization." Thesis, University of Leeds, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378042.

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50

Haneef, Fouzia. "Influence of membrane cholesterol on neurosteroid modulation of benzodiazepine GABAa receptors." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272513.

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