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Dissertations / Theses on the topic 'BC1'

Author: Grafiati

Published: 14 March 2023

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1

Ritter, Michaela. "Cytochrom bc1 eine Studie zum Elektronentransfer der bc1-Komplexe des Bakteriums Paracoccus denitrificans und der Hefe Saccharomyces cerevisiae mittels elektrochemisch induzierter Differenzspektroskopie /." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971616574.

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Baer, Kimberly Kay. "Protein Coevolution and Coadaptation in the Vertebrate bc1 Complex." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1994.pdf.

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3

Vallières, Cindy. "Agents antimicrobiens ciblant le complexe III de la chaîne respiratoire mitochondriale : caractérisation de nouveaux inhibiteurs et étude du développement des résistances." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00840029.

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Des inhibiteurs du complexe bc1 de la chaîne respiratoire mitochondriale ont été développés comme agents antimicrobiens pour lutter contre des pathogènes de l'Homme et de plantes. Ces drogues ciblent les poches catalytiques Qo et Qi formées par le cytochrome b. La comparaison de séquences de cette protéine montre que les sites Qo et Qi sont bien conservés entre les organismes mais qu'il existe toutefois des variations qui pourraient expliquer leur différence de sensibilité aux drogues. A l'aide du modèle levure S. cerevisiae, nous avons étudié les déterminants de la résistance/sensibilité natu

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Gordon, James Alexander. "Design and synthesis of novel cytochrome bc1 inhibitors for the treatment of toxoplasmosis." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22638/.

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Toxoplasmosis is a highly prolific and neglected disease, and current treatments fail to adequately address the challenges it presents. As such development of new more efficacious treatments, tailored to the complex nature of the infection, is required. The causative parasite Toxoplasma gondii is a resilient and resourceful organism, adept at invasion, avoidance and survival within its host. The cytochrome bc1 complex has been proven to be a validated target for the treatment of a number of apicomplexan parasitic diseases, including both malaria and toxoplasmosis. Recent work has also identifi

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Xue, Vincent. "Modeling and designing Bc1-2 family protein interactions using high-throughput interaction data." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120446.

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Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 153-164).<br>Protein-protein interactions (PPIs) play a major role in cellular function, mediating signal processing and regulating enzymatic activity. Understanding how proteins interact is essential for predicting new binding partners and engineering new functions. Mutational analysis is one way to study the determinants of protein interaction. Traditionally, the biophysical study of protein interactions

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Pacorel, Benedicte. "Targeting the Hemoglobin Degradation Pathway and the Cytochrome bc1 Complex of Plasmodium Falciparum Malaria." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507704.

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Kehrein, Kirsten. "Organization of mitochondrial gene expression in yeast : Specific features of organellar protein synthesis." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-107568.

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Mitochondria contain their own genetic system, encoding key subunits of the oxidative phosphorylation system. These subunits are expressed by an organelle-specific gene expression machinery. This work revealed a number of fundamental aspects of mitochondrial gene expression and provides evidence that this process is organized in a unique and organelle-specific manner which likely evolved to optimize protein synthesis and assembly in mitochondria. Most importantly, improving the experimental handling of ribosomes we could show that mitochondrial ribosomes are organized in large assemblies that

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Davoudi, Cedric-Farhad [Verfasser]. "Regulation and assembly of the cytochrome bc1-aa3 supercomplex in Corynebacterium glutamicum / Cedric-Farhad Davoudi." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1189416115/34.

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ACERO, LUIS FERNANDO JR. "T-CELL HOMEOSTASIS AND THE ROLE OF THE PRO-APOPTOTIC Bc1-2 FAMILY MEMBER Bim." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1126725924.

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Cowley, Robin Neil. "The synthesis and development of novel quinolone antimalarials targeting the bc1 protein complex of Plasmodium falciparum." Thesis, University of Liverpool, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569047.

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In recent years investigation of the biological mode of action of the antimalarial compound atovaquone has validated the Plasmodium falciparum bC1 protein complex as a target for the development of novel antimalarials. This project is concerned with the design, synthesis and development of quinolone based antimalarial compounds targeting the Qo site of the Plasmodium falciparum bC1 protein complex. -......, ..•. : - A small array of quinolone-based compounds, substituted at the 3 and 7 positions, has been developed utilising the Gould-Jacobs methodology. The synthesised compounds express activ

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Largueze, Jean-Baptiste. "Modèles membranaires biomimétiques pour l'incorporation du cytochrome bc1 des chaînes de transfert d'électrons photosynthétiques de Rhodobacter sphaeroides." Compiègne, 2011. http://www.theses.fr/2011COMP1927.

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La formation de bicouches lipidiques supportées est réalisée sur la surface des pores d’une électrode d’alumine nanoporeuse. Trois types de modèles membranaires ont été étudiés : une membrane reposant directement sur l’alumine et deux modèles découplés du support, soit par un assemblage biotine/streptavidine, soit par des polymères de PEG2000. La formation au sein des pores des différents modèles passe par l’utilisation de liposomes et une fusion déclenchée par l’emploi d’un agent fusogène. La caractérisation de la membrane est alors suivie par la réduction électrochimique d’ubiquinone incorpo

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KANG-PARK, SUKMI. "Etude de la regulation de l'expression de genes hepatocytaires et biliaires dans la lignee cellulaire d'hepatome bc1." Paris 6, 1996. http://www.theses.fr/1996PA066594.

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Le foie presente lors de son developpement de multiples etapes de proliferation et de differenciation sous le controle de differents facteurs de croissances et d'hormones. Si les capacites de regulateur metabolique de l'insuline et desormais egalement d'agent mitogene sont reconnues, il n'en est pas de meme pour son potentiel d'agent de differenciation. Nous avons pu evaluer ce role au niveau de la differenciation hepatocytaire a partir d'une lignee cellulaire originale d'hepatome humain bc1 c. Guguen-guillouzo, inserm u. 49, qui acquiert spontanement un phenotype hepatocytaire au terme de 3 s

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Lange, Christian. "Wechselwirkungen des Cytochrom-bc1-Komplexes aus Saccharomyces cerevisiae mit seinen Substraten Cytochrom c und Ubichinon sowie mit Membranlipiden." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964744287.

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Damadeu, Kouemo Laura. "Assessing the in vitro efficacy of in silico designed compounds targeting the malarial Qi site of cytochrome bc1." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/67749.

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Plasmodium falciparum is the causative agent of the most commonly fatal form of malaria in Africa with annual deaths of more than 300 000. The rapid development and spread of antimalarial drug resistance by the parasite have stimulated research into the development of new drug classes. Target-based drug discovery have been used as a prominent and efficient tool to identify lead drugs. Reports suggest that selectively inhibiting the parasite mitochondrial electron transport could be a potential treatment effective at multi-stages of the parasite life cycle. Inhibitors of cytochrome bc1 (Cyt bc1

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Lawrenson, Alexandre. "Antimalarial drug design : targeting the Plasmodium falciparum cytochrome bc1 complex through computational modelling, chemical synthesis and biological testing." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/7719/.

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Malaria is a life-threatening disease which is responsible for roughly one million deaths annually. Previous successes in attempting to eradicate the disease have only been short lived, owing to the increased development of resistance in the parasite. There is a continued need for novel compounds which act at novel therapeutic targets, with the Plasmodium falciparum cytochrome bc1 complex (Pfbc1) representing one such target. Its inhibition halts the biochemical generation of ATP, thus resulting in parasite cell death. Work described in this thesis was concerned with utilising molecular modell

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Bruscella, Patrice. "Etude des opérons petI et petII codant pour deux complexes bc1 chez la bactérie acidophile chimioautotrophe stricte Acidithiobacillus ferrooxidans." Aix-Marseille 2, 2004. http://www.theses.fr/2004AIX22086.

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Bincoletto, Claudia. "Autoproliferação celular e expressão do proto-oncogene Bc1-2 em pacientes com leucemia mieloide aguda (LMA) e sindrome mielodisplasica (SMD)." [s.n.], 1998. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314565.

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Orientador: Mary Luci de Souza Queiros<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-23T19:13:58Z (GMT). No. of bitstreams: 1 Bincoletto_Claudia_D.pdf: 4247184 bytes, checksum: a0026bf456d6bf0cd05ab5acf14add45 (MD5) Previous issue date: 1998<br>Resumo: Neste trabalho estudamos o crescimento e diferenciação dos precursores hematopoiéticos da medula óssea, na ausência de fatores estimuladores de colônias (autoproljferação) em vinte e oito pacientes com Leucemia Mielóide Aguda (LMA), doze pacientes com Síndrome Mielodisplás

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18

Gruschke, Steffi. "Early steps in the biogenesis of the bc1 complex in yeast mitochondria : The role of the Cbp3-Cbp6 complex in cytochrome b synthesis and assembly." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81033.

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The inner membrane of mitochondria harbors the complexes of the respiratory chain and the ATP synthase, which perform the key metabolic process oxidative phosphorylation. These complexes are composed of subunits from two different genetic origins: the majority of constituents is synthesized on cytosolic ribosomes and imported into mitochondria, but a handful of proteins, which represent core catalytic subunits, are encoded in the organellar DNA and translated on mitochondrial ribosomes. Using yeast as a model organism, I investigated the mitochondrial ribosomal tunnel exit, the region of the r

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Garcia, Daniel. "Le cytochrome tétrahémique du centre réactionnel de Rhodopseudomonas viridis, sulfoviridis et de Roseobacter denitrificans : structure, fonction et couplage avec le cytochrome BC1." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX22062.

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Nous avons determine le potentiel de demi-reduction et l'orientation par rapport a la membrane de chaque heme du cytochrome tetrahemique du centre reactionnel de trois bacteries photosynthetiques: rhodopseudomonas sulfoviridis mesophile et thermophile et roseobacter denitrificans. Les resultats obtenus montrent qu'il existe une forte similitude entre le cytochrome des souches de rhodopseudomonas sulfoviridis (h#1: +390 mv, 75 ; h#2: +310 mv, 56 ; l#1: +72 mv, 58 ; l#2: -40 mv, 72,5) et celui de rhodopseudomonas viridis deja bien caracterise (h#1: +380 mv, 75 ; h#2: +310 mv, 55 ; l#1: +20 mv, 6

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Cedeno, Diana. "Synthesis of UQ10 Analogs, Measurement of their Midpoint Potentials and their Effects on the Activity of WT and T61V bc1 Complexes from Rhodobacter sphaeroides." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/195424.

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Cytochrome bc1 (Complex III) is an important enzyme that takes part in the respiratory electron transport chain in vertebrates, yeast, and many bacteria. The complex exists as a dimer, in which each monomer contains three catalytic subunits: cytochrome c1, cytochrome b and the Rieske iron-sulfur protein or ISP. Within the inner mitochondrial membranes of eukaryotes, Complex III catalyzes the transfer of two electrons from ubiquinol (UQH2) to cytochrome c, a water-soluble protein, through a process called the modified Q-cycle mechanism. Under very specific conditions, such as mutations within c

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Castellani, Michela [Verfasser], Bernd [Akademischer Betreuer] Ludwig, and Klaas Martinus [Akademischer Betreuer] Pos. "Substrate binding does not only mean catalysis: internal regulation in the cytochrome bc1 complex from Paracoccus denitrificans / Michela Castellani. Gutachter: Bernd Ludwig ; Klaas Martinus Pos." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2011. http://d-nb.info/104419510X/34.

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22

Brasseur, Gaël. "Relations structure-fonction du complexe bc1 chez Saccharomyces cerevisiae : étude de mutants affectés au centre QN de réduction des quinones et d'un mutant d'origine nucléaire." Aix-Marseille 1, 1995. http://www.theses.fr/1995AIX11010.

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Les complexes de type bc sont presents dans les chaines de transfert d'electrons a tous les stades de l'evolution. Le cytochrome b joue un role central dans le fonctionnement du complexe bc1. Afin de preciser les relations structure-fonction du cytochrome b membranaire, quatre mutants de deficience respiratoire et dix revertants ont ete analyses. Les mutants du gene du cytochrome b m221k et s206l sont affectes a la fois dans la reduction et l'oxydation de l'heme b562 par le centre n ; l'hypothese retenue est une instabilite de la semiquinone au centre catalytique de reduction des quinones. Les

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Elbehti, Amina. "La chaîne de transfert d'électrons allant de Fe2 au NAD+ chez Thiobacillus ferrooxidans : mise en évidence d'un transfert inverse d'électrons passant par un complexe de type bc1." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22014.

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La bacterie thiobacillus ferrooxidans presente un double interet: industriel et fondamental. De point de vue industriel c'est la bacterie la plus utilisee dans l'extraction industrielle de metaux a partir de certains type de minerais en les faisant passer en solution: c'est le biolixiviation. De point de vue fondamental t. Ferrooxidans presente deux caracteristiques importantes: 1- elle est acidophile et constitue un materiel de choix pour tester l'universalite du couplage chimioosmotique ; 2- elle est chimioautotrophe stricte et doit assurer la reduction du nad#+ en nadh necessaire pour la fi

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Zeng, Hui [Verfasser], Hartmut [Akademischer Betreuer] Michel, Klaas Martinus [Gutachter] Pos, and Hartmut [Gutachter] Michel. "Structural and functional characterization of cytochrome c oxidase, cytochrome bc1 complex and heme A synthase from Aquifex aeolicus / Hui Zeng ; Gutachter: Klaas Martinus Pos, Hartmut Michel ; Betreuer: Hartmut Michel." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1210555727/34.

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BARRE, PHILIPPE. "Les transferts de genes entre especes de cafeiers diploides : etude des hybrides f1 et bc1 entre c. pseudozanguebariae bridson et c. liberica bull ex. hiern (c. dewevrei de wild et th dur)." Montpellier, ENSA, 1997. http://www.theses.fr/1997ENSA0019.

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Cette etude a pour objet l'evaluation des possibilites de transferts de genes entre deux especes de cafeiers diploides (2n = 2x = 22) phylogenetiquement eloignes : coffea pseudozanguebariae (pse) originaire du kenya et de tanzanie et c. Liberica-dewevrei (dew) originaire d'afrique centrale. Les recombinaisons ont ete etudiees d'une part a l'aide de l'hybridation genomique in situ (hgis) et de la cytometrie en flux et d'autre part a l'aide de marqueurs moleculaires (rflp). De plus, l'heritabilite de la teneur en cafeine, presente chez dew et absente chez pse, a ete etudiee ainsi que la recherch

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Hogarth, Linda A. "The molecular mechanisms of drug resistance in childhood acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263034.

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27

Frolka, Jakub. "BCH kódy." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219462.

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The work deals with data security using BCH codes. In the work are described BCH codes in binary and non-binary form, and their most important subclass RS codes. Furthermore, this work describes the method of decoding Peterson-Gorenstein-Zierl, Berlekamp- Massey and Euclidean algorithm. For the presentation of encoding and decoding process, the application was created in Matlab, which has two parts – Learning BCH codes and Simulation of BCH codes. Using the generated application performance of BCH codes was compared at the last part of the work.

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Sacharuk, Jasmine. "Late Shang (1200 BCE - 1046 BCE) bronze casting technology and technological behaviour." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50036.

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This project examines the bronze casting technology of the late Shang Dynasty (1200-1046 BCE). Despite extensive scholarship on the bronzes themselves, the details of the casting process have remained unclear. Considering the relevance of the bronzes in terms of ritual and burial practices, class hierarchy, and royal affiliation, understanding the production behind the bronzes can reveal a great deal about the lives of everyday Shang craftspeople and Shang society as a whole. This project examines bronze foundry remains from Yinxu, the ruins of the last capital of the Shang Dynasty, in an atte

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Ng, Florence Wai Hung. "Identification and characterization of Bcl-2/Bcl-X¦L interacting protein, p28Bap31." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0015/NQ44531.pdf.

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Liu, Xiaohua. "Spin Excitations in BCC, FCC, HCP Cobalt and BCC Fe1-xCox Alloys /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487932351057225.

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Gomes, Francisco. "Millennium BCP: precarious environment." Master's thesis, NSBE - UNL, 2013. http://hdl.handle.net/10362/9877.

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Abed, Shahla. "Läkemedel mot Bcl-2 överuttryckande resistenta Prostatatumörer : Läkemedel mot Bcl-2 överuttryckande resistenta Prostatatumörer." Thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106293.

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Svangren, Henrik. "Konceptstudie av kassadisk B10/B11." Thesis, Jönköping University, JTH, Mechanical Engineering, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-942.

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<p>This master’s thesis report is a summary of the analysis performed together with ITAB Shop Concept located in Jönköping, Sweden. As a last element of the Master’s program at the School of Engineering, this 20 point level D thesis project has been the final work to bring my education to an end.</p><p>ITAB Shop Concept expressed an aspiration that the Shop Counter Program B10/B11 should undergo an analysis to point out and possibly lead to improvement.</p><p>Through interviews and data collection proposals for possible improvements has been drawn up and the analysis points out current deficie

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Szafir, Daniel J. "Non-Invasive BCI through EEG." Thesis, Boston College, 2010. http://hdl.handle.net/2345/1208.

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Thesis advisor: Robert Signorile<br>It has long been known that as neurons fire within the brain they produce measurable electrical activity. Electroencephalography (EEG) is the measurement and recording of these electrical signals using sensors arrayed across the scalp. Though there is copious research in using EEG technology in the fields of neuroscience and cognitive psychology, it is only recently that the possibility of utilizing EEG measurements as inputs in the control of computers has emerged. The idea of Brain-Computer Interfaces (BCIs) which allow the control of devices using brain s

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Dias, Cleverton Oliveira. "Teoria BCS com efeito Rashba." Universidade Federal do Amazonas, 2015. http://tede.ufam.edu.br/handle/tede/4987.

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Goodberry, Benjamin Nathaniel. "Multiparameter BCn-Kostka-Foulkes Polynomials." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/83576.

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The Kostka-Foulkes polynomials describe the change of basis between Schur polynomials and Hall-Littlewood polynomials. In this paper, we extend this idea to the family of BCn Macdonald spherical functions, with multiparameter Kostka-Foulkes polynomials acting as the change of basis from the BC_n spherical functions to the type Cn Schur polynomials. We develop a Kato-Lusztig formula that describes the multiparameter BCn-Kostka-Foulkes polynomials.<br>Master of Science

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Lukášová, Pavlína. "Cloud Computing jako nástroj BCM." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-75556.

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This thesis deals with possible interconnections between two concepts playing a big role in contemporary business and IT world. These concepts are Business Continuity Management and Cloud Computing. In the scope of this thesis there are certain areas identified where both concepts are complement, where Cloud Computing brings new opportunities for Business Continuity Management and where could possible problems arise during particular implementation. From the BCM perspective the impact lies on IT services, from the Cloud Computing perspective the thesis deals especially with security aspects. T

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Kašpar, Jaroslav. "Zabezpečení přenosu dat BCH kódy." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217733.

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The thesis Data transmission error-protection with BCH codes deals with a large class of random-error correcting cyclic codes which are able to protect binary data and can be used for example in data storages, high speed modems. Bose, Chaudhuri and Hocquenghem (BCH) codes operate over algebraic structures called Galois fields. The BCH encoding is the same as cyclic encoding and can be done with linear feedback shift register but decoding is more complex and can be done with different algorithms - in this thesis there are two algorithms for decoding Peterson and Berlekam-Massey mentioned. The a

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Barrezueta, Luis Fernando Mesias [UNIFESP]. "Imuno-expressão das proteínas da família BCL-2 (BCL-2. BCL-XL, BAX, BAK, BAD) em câncer gátrico, preparados em arranjo em matriz (TMA)." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9724.

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Made available in DSpace on 2015-07-22T20:50:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-01-28<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Em casos de carcinoma gástrico, para contribuir ao conhecimento do processo de carcinogênese: Objetivo: Estudar a expressão das proteínas da família Bcl-2 (BcI-2, Bcl-xl, Bak, Bad, Bax). Correlacionar a expressão destas proteínas com 0 índice apoptótico mediante a expressão da proteína Caspase 3 clivada, com 0 índice mit6tico mediante a expressão

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Costa, Júnior Abadio de Oliveira da. "Produção de vacina BCG recombinante expressando proteína de fusão CMX e avaliação da indução de células B de memória." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7180.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-19T13:21:42Z No. of bitstreams: 2 Dissertação - Abadio de Oliveira da Costa Júnior - 2014.pdf: 3197815 bytes, checksum: d02da71e811f6bb81bc8437632974703 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-19T13:22:01Z (GMT) No. of bitstreams: 2 Dissertação - Abadio de Oliveira da Costa Júnior - 2014.pdf: 3197815 bytes, checksum: d02da71e811f6bb81bc8437632974703 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e98

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Bah, Nourdine. "Contrôle du déclenchement de l'apoptose pendant l'arrêt mitotique par l'homologue de Bcl-2, Bcl-xL." Nantes, 2013. http://archive.bu.univ-nantes.fr/pollux/show.action?id=d6222d04-bb86-43e6-810b-21a673a07295.

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Les poisons des microtubules, comme le paclitaxel, sont des composés qui modifient la dynamique des microtubules, et bloquent les cellules en mitose par non-satisfaction du point de contrôle mitotique. La principale cible du point de contrôle mitotique est l'APC/C, une ligase E3 qui régule la dégradation de protéines importantes pour la progression de la mitose. Un de ces substrats est la cycline BI, le cofacteur essentiel à l'activité de Cdk1 , et par conséquent essentiel pour le maintien de la mitose. Sous paclitaxel, le point de contrôle mitotique est actif, et cela aboutit à un blocage en

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Kuma, Rita Dela. "Paste charaterization of 3rd and 4th millennium BCE ceramics from Arslantepe, Turkey (3350-2800 BCE)." Master's thesis, Universidade de Évora, 2016. http://hdl.handle.net/10174/20855.

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ABSTRACT: This research aims at defining the main characteristics of technological and compositional variability of ceramic production at Arslantepe during Periods VIA, VIB1 and VIB2 (3400-2800BC) in a framework of socioeconomic and political development. The stereomicroscope in a reflectance mode at a magnification of 1–6.3x was used to analyze a total number of 158 ceramic samples to identify and characterize the principal inclusions in the ceramic pastes, their dimensions, shape, color, concentration, distribution, which may be well-dispersed or clustered, and orientation. The stereomicrosc

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Schaller-Schönitz, Michael [Verfasser]. "Der Einfluss von BCR-ABL auf STAT5 in BCR-ABL-positiven Leukämiezellen / Michael Schaller-Schönitz." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover, 2011. http://d-nb.info/1012635929/34.

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Rosa, Larissa Camargo da [UNESP]. "Potencial profilático de estratégias vacinais no diabetes experimental." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/89956.

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Made available in DSpace on 2014-06-11T19:24:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-07-30Bitstream added on 2014-06-13T18:52:00Z : No. of bitstreams: 1 rosa_lc_me_botfm.pdf: 636625 bytes, checksum: 4e80c747550326696f8ac42a9a3aed5a (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Universidade Estadual Paulista (UNESP)<br>O diabetes tipo I é uma doença causada pela destruição autoimune das células do pâncreas que resulta em deficiência na produção de insulina. O objetivo deste pro

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Diniz, Ricardo. "Modelo de bósons interagentes e sua relação com o BCS." Universidade de São Paulo, 1990. http://www.teses.usp.br/teses/disponiveis/43/43131/tde-30042014-152410/.

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Através de um hamiltoniano efetivo baseado no tratamento de NAMBU POT.90 para o BCS, no qual incluímos além do emparelhamento monopolar o emparelhamento quadrupolar, discutimos a relação entre esse modelo e o modelo de bósons interagentes. Uma aplicação e feita a cadeia o (6) do IBM, que corresponde ao limite GAMA-instável do modelo de bohr. As dificuldades encontradas e uma possível generalização para o modelo são discutidas.<br>The nambu mechanism for BCS theory is extended with inclusion of quadrupole pairing in adition to the usual monopole pairing. An effective Hamiltonian is constructed

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Pécot, Jessie. "Dépendance des cellules cancéreuses à BCL-xL : ciblage thérapeutique du réseau d'interactions PUMA, BAX et BCL-xL : effets oncogéniques non canoniques de l'interaction RAS / BCL-xL." Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=57dfe09c-18e6-4d60-a1e1-cbc567f5cda6.

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La protéine BCL-xL fréquemment surexprimée dans les cancers est impliquée dans la résistance aux chimiothérapies. De nouvelles molécules ciblant cette protéine ont ainsi été développées. Le travail présenté dans le cadre de cette thèse montre que, malgré une spécificité de plus en plus grande de ces molécules, elles restent inefficaces à antagoniser certaines interactions impliquant BCL-xL. Ainsi un traitement au WEHI-539 (ciblant spécifiquement BCL-xL) ne sensibilise pas des cellules surexprimant BCL-xL à une mort dépendante de PUMA, une protéine interagissant avec BCL-xL qui joue un rôle ess

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Tidare, Jonatan, and Mattias Bäckström. "A BRAIN-ACTUATED ROBOT CONTROLLER FOR INTUITIVE AND RELIABLE MANOEUVRING." Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-31812.

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During this master-thesis a robot controller designed for low-throughput and noisy EEG-data of a Brain Computer Interface (BCI) is implemented. The hypothesis of this master-thesis state that it is possible to design a modular and platform independent BCI-based controller for a mobile robot, which regulates the autonomy of the robot as a function of the user’s will to control. The BCI design is thoroughly described, including both the design choices regarding used brain activity signals and the pre- and post-processing of EEG data. The robot controller is experimentally tested by completing a

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Suhada, Robert. "The XMM-BCS galaxy cluster survey." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-132857.

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Al-Zarouni, Mansour. "Expression of recombinant antigen in BCG." Thesis, University of Surrey, 2000. http://epubs.surrey.ac.uk/843308/.

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Little is known about the effect of different modes of expression of an antigen in rBCG on immune response. An appropriate wing of the immune system, with different degrees, is activated upon encounter with a foreign antigen. Knowledge of these responses is vital to the development of future recombinant vaccine. Various E. coli-mycobacterial species shuttle vector constructs were made using a combination of mycobacterial promoters and signal sequences. Thus enabling foreign antigens to be expressed cytoplasmically or secreted outside rBCG as native proteins or membrane-associated lipoproteins.

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Cerrito, Stefano. "Thermodynamics of the BCS-BEC crossover." kostenfrei, 2007. http://mediatum2.ub.tum.de/doc/623023/document.pdf.

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