Academic literature on the topic 'Basin restriction'
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Journal articles on the topic "Basin restriction"
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Meyer, Edward E., Blair N. Burgreen, Hilary Lackey, Joshua D. Landis, Andrew N. Quicksall, and Benjamin C. Bostick. "Evidence for basin restriction during syn-collisional basin formation in the Silurian Arisaig Group, Nova Scotia." Chemical Geology 256, no. 1-2 (October 2008): 1–11. http://dx.doi.org/10.1016/j.chemgeo.2008.06.016.
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Smith, Benjamin P., Toti Larson, Rowan C. Martindale, and Charles Kerans. "Impacts of basin restriction on geochemistry and extinction patterns: A case from the Guadalupian Delaware Basin, USA." Earth and Planetary Science Letters 530 (January 2020): 115876. http://dx.doi.org/10.1016/j.epsl.2019.115876.
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Rouchy, J. M., C. Taberner, M. M. Blanc-Valleron, R. Sprovieri, M. Russell, C. Pierre, E. Di Stefano, et al. "Sedimentary and diagenetic markers of the restriction in a marine basin: the Lorca Basin (SE Spain) during the Messinian." Sedimentary Geology 121, no. 1-2 (October 1998): 23–55. http://dx.doi.org/10.1016/s0037-0738(98)00071-2.
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Qiu, Lei, Shuang Zhao, and Hui Min Wang. "The Motivation and Restriction Mechanisms of Emission Trading in the Tai Lake Basin." Advanced Materials Research 831 (December 2013): 299–303. http://dx.doi.org/10.4028/www.scientific.net/amr.831.299.
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This paper offers a Government-Enterprise-Public cooperation mode of emission trading in the Tai Lake Basin based on the governing theory of the common pool resources. Then, the motivation and restriction mechanisms have been designed, that is, a water environmental regulation contract with the effect of incentive and constraint penalty is signed between the water environmental management institute and the enterprises. Further, a principal-agent model is developed, by which a set of results of the water environment regulation optimal contract is obtained. The effects of public participation and local government protection probability on the contract are analyzed. The results show that the increase of public participation could decrease the optimal fine amount, which will weaken the contradictions between the local government and the enterprises, and the decrease of the local government protection probability would reduce the regulatory frequency, correspondingly the supervision cost will be low.
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Paula-Santos, Gustavo M., Sergio Caetano-Filho, Marly Babinski, Ricardo I. F. Trindade, and Cristian Guacaneme. "Tracking connection and restriction of West Gondwana São Francisco Basin through isotope chemostratigraphy." Gondwana Research 42 (February 2017): 280–305. http://dx.doi.org/10.1016/j.gr.2016.10.012.
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Frizzone, José Antonio, Sílvio Carlos Ribeiro Vieira Lima, Claudivan Feitosa Lacerda, and Luciano Mateos. "Socio-Economic Indexes for Water Use in Irrigation in a Representative Basin of the Tropical Semiarid Region." Water 13, no. 19 (September 25, 2021): 2643. http://dx.doi.org/10.3390/w13192643.
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Performance evaluation of irrigated agriculture is an important tool that assists in decision-making on water management in the river basin, particularly in tropical semiarid regions. This study was carried out using information from the Jaguaribe River basin, located in the Northeast region of Brazil, which has an important restriction in the availability of water resources and high competition for water use. From a set of indicators (production, water, economic, and social), the overall performance index of irrigated agriculture was estimated (ranging from zero to 1.0) for two scenarios: high water scarcity and low water scarcity. The performance index used was based on the mean value of these security criteria normalized with respect to the maximum value of the indicator for the crop obtained in the sub-basin. A low performance index of irrigated agriculture (less than 0.3) has always been associated with inadequacy of more than one security indicator. Crops with significant cultivated areas and, therefore, requiring a high volume of irrigation, such as rice, sugar cane, banana, and green coconut, require technical interventions related to the management of the soil–water–plant system aiming at improving yield with less water. Under conditions of water restrictions, crops with performance indexes higher than 0.3 should be prioritized. The study presented here for Jaguaribe River basin may support public policies related to irrigation and agronomic techniques necessary to improve the performance of agricultural under tropical dry lands.
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Guénette, S., R. Fortin, and E. Rassart. "Mitochondrial DNA Variation in Lake Sturgeon (Acipenser fulvescens) from the St. Lawrence River and James Bay Drainage Basins in Quebec, Canada." Canadian Journal of Fisheries and Aquatic Sciences 50, no. 3 (March 1, 1993): 659–64. http://dx.doi.org/10.1139/f93-076.
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Restriction fragment length pattern analysis of mitochondrial DNA (mtDNA) was used to assess genetic differentiation in sympatric lake sturgeon (Acipenser fulvescens) from the St. Lawrence River drainage basin (St. Lawrence and Ottawa rivers and Lac des Deux Montagnes) and in sturgeon from the Waswanipi River (James Bay drainage basin). Using 14 restriction enzymes on mtDNA from 82 specimens, the genetic divergence was relatively low (d = 0.219–0.744%), as only three genotypes were found. Genotype 1 is present at all sites whereas genotype 2 is present only in Lac des Deux Montagnes and the Ottawa and Waswanipi rivers. The St. Lawrence River sturgeon form a homogeneous genotypic group that was not found significantly different from sturgeon from Lac des Deux Montagnes. The genetic heterogeneity seemed higher in the James Bay drainage population than in the St. Lawrence drainage populations that probably have been more significantly influenced by overfishing and man-made habitat changes.
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Mänd, Kaarel, Stefan V. Lalonde, Kärt Paiste, Marie Thoby, Kaarel Lumiste, Leslie J. Robbins, Timmu Kreitsmann, et al. "Iron Isotopes Reveal a Benthic Iron Shuttle in the Palaeoproterozoic Zaonega Formation: Basinal Restriction, Euxinia, and the Effect on Global Palaeoredox Proxies." Minerals 11, no. 4 (March 31, 2021): 368. http://dx.doi.org/10.3390/min11040368.
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The Zaonega Formation in northwest Russia (~2.0 billion years old) is amongst the most complete successions that record the middle of the Palaeoproterozoic era. As such, geochemical data from the formation have played a central role in framing the debate over redox dynamics in the aftermath of the Great Oxidation Event (GOE). However, uncertainty over local redox conditions and the degree of hydrographic restriction in the formation has led to contradictory interpretations regarding global oxygen (O2) fugacity. Here, we provide new iron (Fe) isotope data together with major and trace element concentrations to constrain the local physiochemical conditions. The Zaonega Formation sediments show authigenic Fe accumulation (Fe/Al ≫ 1 wt.%/wt.%) and δ56Fe ranging from −0.58‰ to +0.60‰. Many of the data fall on a negative Fe/Al versus δ56Fe trend, diagnostic of a benthic Fe shuttle, which implies that Zaonega Formation rocks formed in a redox-stratified and semi-restricted basin. However, basin restriction did not coincide with diminished trace metal enrichment, likely due to episodes of deep-water exchange with metal-rich oxygenated seawater, as evidenced by simultaneous authigenic Fe(III) precipitation. If so, the Onega Basin maintained a connection that allowed its sediments to record signals of global ocean chemistry despite significant basinal effects.
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Mulligan, Timothy J., Robert W. Chapman, and Bonnie L. Brown. "Mitochondrial DNA Analysis of Walleye Pollock, Theragra chalcogramma, from the Eastern Bering Sea and Shelikof Strait, Gulf of Alaska." Canadian Journal of Fisheries and Aquatic Sciences 49, no. 2 (February 1, 1992): 319–26. http://dx.doi.org/10.1139/f92-036.
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Increased fishing effort in the international waters of the Aleutian Basin has focused much interest on defining the stock structure of walleye pollock, Theragra chalcogramma, in the Bering Sea. Variation in mitochondrial DNA (mtDNA) was examined via restriction endonuclease digestions in 168 walleye pollock from three areas in the eastern Bering Sea and from Shelikof Strait, Gulf of Alaska. Nine endonucleases produced variant restriction patterns both within and among populations. A total of 50 restriction sites were revealed along the mtDNA molecule. Two dominant genotypes were found in 39 and 21 individuals, respectively. Fifty-one genotypes (78% of the total) were represented by a single specimen. Clustering of genetic distances suggests the existence of several walleye pollock stocks in the Bering Sea and Gulf of Alaska. Genetic divergence among stocks may be related to the prevailing current patterns found in these areas.
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Crombez, Vincent, Sébastien Rohais, François Baudin, Benoit Chauveau, Tristan Euzen, and Didier Granjeon. "Controlling factors on source rock development: implications from 3D stratigraphic modeling of Triassic deposits in the Western Canada Sedimentary Basin." Bulletin de la Société géologique de France 188, no. 5 (2017): 30. http://dx.doi.org/10.1051/bsgf/2017188.
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The recent development of unconventional resources has triggered a regain of interest for source-rocks. The presence of hydrocarbons in these unconventional systems is generally associated with organic-rich sediments. This study aims at better understanding the factors controlling the accumulation of marine organic matter at basin scale, using a process-based approach. This work focuses on the Montney, Doig and Halfway Formations (Lower and Middle Triassic, Alberta and British Columbia, Canada). Recent studies show that the Triassic strata of the Western Canada sedimentary basin can be considered as a transitional period between the Paleozoic passive margin and the Jurassic foreland basin. Based on a 3D regional stratigraphic architecture and on a description of the organic rich interval distribution, a process-based numerical model (DionisosFlow and DORS) has been used to simulate the stratigraphic evolution of the Montney, Doig and Halfway Formations and reproduce the organic distribution in these formations. This modeling approach allowed us to test different scenarios of primary productivity and basin restriction and discuss the regional controls on organic matter accumulation such as dynamic of anoxia or dilution of organic matter by detrital sediments. The reconstruction of the stratigraphic architecture emphasizes a major drop of the water discharge in the basin. In the absence of any evidence supporting a link with a climate change, the drop in water discharge suggests a major modification of the drainage area of the basin, potentially associated with the early stage of the cordilleran orogeny and foreland basin evolution. The numerical simulation also shows that the primary productivity rates in the Montney and Doig Formations are characteristic of a coastal area and that a basin restriction is required to account for the level of anoxia observed in the studied Formations. Lastly, this study investigates the regional controls on organic matter accumulation and emphasizes the impact of regional paleogeographic and geodynamic evolution on the dynamic of anoxia and on the dilution.
Dissertations / Theses on the topic "Basin restriction"
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Melchin, Paul. "The Semantic Basis for Selectional Restrictions." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38831.
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In this thesis I investigate the relationship between the semantics of a verb and its selectional restrictions, which determine how many and what kind of arguments it must occur with in a clause. For most verbs, these restrictions are predictable from the semantics of the verb, but there are pairs of verbs with very similar semantics that differ in their argument restrictions. For example, both ask and wonder can take questions as their complements (John asked/wondered what time it was), but of the two, only ask can take a noun phrase complement with a question-like interpretation (John asked/*wondered the time). Similarly, while both eat and devour are verbs of consumption, the object can be omitted with eat but not devour (John ate/*devoured yesterday). Due to these and similar examples, many linguists have claimed that selectional restrictions are to some extent arbitrary and unpredictable from the semantics, and therefore must be learned as part of our knowledge of the relevant verbs. In this thesis I argue that these differences are not arbitrary; they recur across languages, and they can be predicted on the basis of lexical semantics, meaning they do not need to be learned on a word-by-word basis.
In order for selectional features to be eliminated from the grammar, and replaced with semantic generalizations, two things must be shown. First, it must be demonstrated that the elements being selected for can be defined in terms of their semantics, rather than their syntactic properties. If not, the selectional properties could not be considered to be fully predictable based on the semantics of the selecting and selected items. Second, it must be shown that the selectional restrictions of a predicate are predictable from components of the selecting predicate’s meaning. In other words, the semantics of both the selected and the selecting elements must be accounted for. I focus mainly on the semantics of selected elements in Chapter 2, and on selecting elements in Chapters 3 and 4.
Chapter 2 provides a brief review of the literature on selectional features, and argues that the elements being selected need not be defined in terms of their syntactic category and features. Instead, what are selected for are the semantic properties of the selected items. While the relationship between syntactic and semantic categories and properties is often systematic, it is not always, which can make it difficult in certain cases to determine the semantic basis for predicting what elements will be selected. Specifically, I argue that what appears to be selection for clausal categories (CPs or TPs) is in fact selection for propositional entities (including questions, assertions, facts, and so on); apparent selection for bare verb phrases (vPs) is selection for eventualities (events or states); and apparent selection for nominals (DPs) is selection for objects or things. Only properties of the nearest semantic entity (i.e., excluding elements embedded therein) can be selected for. In this way, I account for the selectional asymmetries between clausal and nominal complements noted by Bruening (2009) and Bruening et al. (2018): predicates selecting clausal complements can only select for (semantic) properties of the upper portion of the clause (in the CP domain), not for the lower portion (the vP domain), while predicates taking nominal complements can select for any properties of the nominal rather than being restricted to the upper portion. Since all syntactic properties of items are encoded as features, on a syntactic account it is expected that all features should be involved in selectional restrictions, contrary to fact; the semantic approach taken here allows for a principled explanation of what can and cannot be selected for.
In Chapters 3 and 4 I turn to the lexical semantics of selecting elements, showing that these too are involved in determining selectional restrictions. I start in Chapter 3 by looking at c-selection (i.e., syntactic selection), specifically the case of eat versus devour. As mentioned above, their selectional properties of these two verbs differ in that the complement of eat is optional, while that of devour is obligatory, despite the two verbs having similar meanings. I show that this is due to the aspectual properties of these verbs: devour denotes an event where the complement necessarily undergoes a complete scalar change (i.e., it must be fully devoured by the end of the event), which means that the complement must be syntactically realized (Rappaport Hovav and Levin 2001; Rappaport Hovav 2008). Eat, on the other hand, does not entail a complete change of state in its complement, and so the complement is optional. I show that the correlation between scalar change entailments and obligatory argument realization holds for a wider group of verbs as well. Thus, the c-selectional properties of eat, devour, and similar verbs need not be stipulated in their lexical entries.
In Chapter 4 I turn to the selection of complements headed by a particular lexical item, as with rely, which requires a PP complement headed by on, a phenomenon commonly referred to as l-selection. I show that the sets of verbs and prepositions involved in l-selection, and the observed verb-preposition combinations, are not fully random but can instead be (partially) predicted based on the thematic properties of the items in question. Furthermore, I show that there are different kinds of l-selecting predicates, and one kind is systematically present in satellite-framed languages (like English) and absent in verb-framed languages (like French), based on the Framing Typology of Talmy (1985, 1991, 2000). I account for this difference by analyzing l-selection as an instance of complex predicate formation, and showing that a certain kind of complex predicate (exemplified by rely on) is possible in satellite-framed languages but not in verb-framed languages.
Thus, I show that the features that get selected for are semantic features, and that the problematic cases of eat versus devour and l-selection have semantic correlates, and need not be stipulated in the lexicon. While this leaves many instances of selectional features unaccounted for, it provides proposals for some components of lexical semantics that are relevant to selection, and demonstrates that a research program directed toward eliminating the remaining cases is plausibly viable.
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Gallagher, Gillian Elizabeth Scott. "The perceptual basis of long-distance laryngeal restrictions." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59263.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 190-194).
The two main arguments in this dissertation are 1. That laryngeal co-occurrence restrictions are restrictions on the perceptual strength of contrasts between roots, as opposed to restrictions on laryngeal configurations in isolated roots, and 2. That laryngeal cooccurrence restrictions are restrictions on auditory, as opposed to articulatory, features. Both long-distance laryngeal dissimilation, where roots may have one but not two laryngeally marked stops (MacEachern 1999), and assimilation, where stops in a root must agree in laryngeal features (Hansson 2001; Rose and Walker 2004) are given a unified account based on a grammatical pressure to neutralize indistinct contrasts. This analysis is supported by the finding that certain non-adjacent sounds interact in perception. Specifically, the perception of a contrast in ejection or aspiration is degraded in roots with another ejective or aspirate as compared to another plain stop (e.g. the pair k'ap'i-kap'i is more confusable than the pair k'api-kapi). Roots that are minimally distinguished by having one vs. two laryngeally marked stops are confusable (e.g. k'ap'i is confusable with kap'i), and thus languages may avoid having both types of roots. The analysis integrates long-distance neutralizations with analyses of local neutralizations based on phonetic cues and contrast strength (Flemming 1995, 2004; Steriade 1997), showing that both local and non-local phenomena are driven by constraints against perceptually indistinct contrasts. The interaction between ejectives and aspirates in Quechua provides evidence for auditory features. These two articulatorily disparate sounds pattern together in the cooccurrence restrictions of Quechua, showing that some feature must pick them out as a class. It is argued that ejectives and aspirates may pattern together because they share long voice onset time. It is shown that defining laryngeally marked stops based on their language specific auditory properties correctly accounts both for ejective-aspirate interactions in Quechua and also for the interaction between ejectives and implosives in Hausa and Tz'utujil.
by Gillian Elizabeth Scott Gallagher.
Ph.D.
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Moncorgé, Olivier. "The molecular basis of host range restriction of avian influenza virus polymerases in mammalian hosts." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10934.
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Influenza A virus adaptation to humans is a rare but recurrent event that can result in a pandemic. The influenza polymerase, composed of the viral proteins PB1, PB2 and PA, is responsible for transcription and replication of the viral genome. Typical avian-origin influenza polymerases are restricted in human cells and polymerase subunit PB2 is particularly involved in this restriction. Residue 627 of PB2 is a glutamic acid in almost all avian influenza viruses, and mutation to a lysine is a potent enhancer of avian polymerase function in human cells. However, the underlying molecular mechanism and the cellular factors modulating avian-origin influenza replication in mammals are not known. Using a cell based replication assay in heterokaryons formed between avian and human cells, we concluded that the restriction is not due to a dominant human inhibitory factor. We also showed that supply of avian factors to human cells stimulated the activity of an avian-origin influenza polymerase and a functional screen was set up to attempt to isolate such chicken co-factor(s). We hypothesised that PB2 E627K mutation enhances the viral polymerase activity by optimizing an interaction with a human co-factor. A biochemical approach was used to try to identify this factor. Pigs are thought to be more susceptible to avian influenza than other mammalian species and are a supposed “mixing vessel” for influenza A viruses. To compare the replicative capacity of different influenza polymerases in pig, human and avian cells, an influenza polymerase assay in pig cells was set up. This assay was also used to study the impact in pig cells of known PB2 mammalian adaptive mutations. No obvious difference in the capacity of pig and human cells to support influenza polymerase activity was found, questioning the suggested susceptibility of pigs to influenza. Viruses from the avian H9N2 G1 lineage have been responsible for some human infections. Despite having none of the known mammalian signatures, we found the H9N2 G1 polymerase was active in human and pig cells. This study identified H9N2 G1 PA protein as being particularly mammalian adapted, highlighting the role of PA in influenza mammalian adaptation.
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van, der Neut Wendy. "Consensual exploitation : the moral wrong in exploitation and legal restrictions on consensual exploitative transactions." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9594.
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This thesis is about so-‐called consensual exploitative transactions: transactions to which all parties agree voluntarily, and which are beneficial for all parties, but which are still widely considered exploitative, and for that reason legally restricted in many countries. The thesis asks two main questions: 1. What is wrong with consensual exploitation? 2.What implications does the answer to this question have for the legal restriction of consensual transactions that are regarded exploitative in modern liberal societies? In answer to the first research question, the thesis starts by distinguishing and analysing five competing views of the wrong in consensual exploitation that exist in the present-‐day philosophical debate on exploitation; and rejects all five answers. Next, the thesis offers an alternative answer, which is that the wrong in consensual exploitation can best be understood as a matter of greediness—a failure of the virtue of generosity. The thesis then turns to the second research question: what understanding exploitation as greediness implies for the legal restriction of exploitative transactions. It discusses and rejects the view that law ought only to be used to regulate ‘right’ and ‘wrong’ behaviour, and not to promote virtues or discourage vices, such as generosity and greediness. The thesis argues that legal restrictions on consensual exploitative transactions can be justified as a means to prevent greediness, and to promote a certain other-‐regardingness, and illustrates this argument with two examples of laws that regulate consensual transactions which are widely regarded exploitative: minimum wage laws and payday loan laws.
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Zeestraten, Chantal. "Élaboration d'un système d'alerte aux étiages à l'échelle du bassin versant de la rivière Yamaska au Québec." Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6219.
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Diverses études hydrologiques suggèrent que les changements climatiques anticipés entraîneront une diminution des débits d'étiage pour une majorité des rivières du sud du Québec. Cette situation risque de devenir particulièrement préoccupante dans le bassin versant de la rivière Yamaska, car son débit estival est déjà faible. Puisque cette rivière est la principale source d'approvisionnement en eau pour différentes municipalités et les industries qu'elles desservent, des actions doivent être entreprises avant d'en arriver à des situations critiques. Un système d'alerte basé sur des débits seuils jumelé à une prévision météorologique constituerait un outil de gestion puissant. L'élaboration d'un tel système d'alerte nécessite une bonne connaissance de la rivière. Des analyses statistiques des différents épisodes d'étiage survenus dans les années passées permettent d'en faire ressortir les débits historiques ainsi que d'en comprendre le comportement en tarissement. Une revue bibliographique et l'analyse de différents modèles de prévision des débits permettent de déterminer les modèles qui s'appliquent le mieux au bassin de la rivière Yamaska. Des mesures de restriction pour chacun des différents niveaux du système d'alerte proposé doivent être déterminées en s'inspirant des différentes mesures de restriction présentes dans différents pays, tout en tenant compte des facteurs économiques et politiques. Aussi, les critères écologiques et fonctionnels doivent être pris en compte lors de l'établissement de ces débits seuils. Sur la base d'un suivi d'indicateurs et de prévisions associées, ce mémoire propose donc un système d'alerte qui indiquera le moment où des mesures restrictives de prélèvement et de consommation doivent commencer à être appliquées. En plus de constituer un outil puissant pour le bassin versant de la rivière Yamaska, ce prototype de système d'alerte aux étiages pourra être adapté à d'autres bassins versants du Québec enclins aux étiages sévères.
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Alsalmi, Hussain Sulaiman. "Oman's basic statute and human rights : protections and restrictions with a focus on nationality, Shura and Freedom of Association." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/omans-basic-statute-and-human-rights-protections-and-restrictions-with-a-focus-on-nationality-shura-and-freedom-of-association(9c411873-6252-4ee1-b574-40ff59e94867).html.
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Over the last three decades, Oman has emerged as a center of political and economic stability in the Arab world, a stability which is an essential ingredient for any country to develop and flourish. Whereas democracy and public freedoms are at the core of stability in other parts of the world, the case in Oman is different. It is not a democratic state and it did not adopt the modern concepts of human rights and public freedoms into its legal-political system until 1996 when the Basic Statute of the State was promulgated. The purpose of this study is to provide a general view of the current status of Human Rights under the Omani Basic Statute of the State with a specific focus on some civil and political rights. It illustrates the situation of human rights by assessing the implementation of the constitutional and legal safeguards into practice and finding out what hinders them. It aims to evaluate the importance of the constitution in Oman, and the extent to which it has succeeded in incorporating international human rights’ standards while walking the tightrope of reconciling this with core traditional social customs and Islamic values. It analyses the compatibility of constitutional and national laws and practice with international human rights standards and assesses current trends and policies. Three case studies for different rights and freedoms are conducted to explore the guarantees and weaknesses of different rights in practice. These are the areas of nationality 'as individual right' which is very important under the Oman system as it is the direct link to enjoyment of other rights and freedoms. The Shura is the second case study as a political right or a collective right which represents public participation in Oman. Finally, the Freedom of Association, as an example for the freedom of expression and opinion, which represents individual and group rights together. This research evaluation analyses in detail the developments since the promulgation of the Basic Statute in December 1996 but stretches to encompass developments till the developments to the end of July 2011.
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Gunnar, Erika. "Characterization of the genetic basis in two cases of abetalipoproteinemia reveals two novel mutations." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-58620.
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BACKGROUND: Abetalipoproteinemia (ABL) is a rare autosomal recessive disorder caused by mutations in the gene coding for microsomal triglyceride transfer protein (MTTP).
AIM: To characterize the genetic basis of ABL in two unrelated patients.
RESULTS: In the first patient, the substitution c.1911C>T in exon 12 of the MTTP gene, resulting in the protein substitution p.P552L, was discovered using mutation screening. The parents are heterozygous and the proband is a homozygous carrier of this substitution. Using restriction fragment length polymorphism (RFLP), 100 control subjects were analyzed and none carried the substitution indicating that it is a novel MTTP mutation. Sequencing of the other ABL patient showed that the proband carried a homozygous single base insertion, at position c.2342IVS16+2-3insT, located at the donor splice-site of intron 16 resulting in skipping of exon 16 and truncation of the protein. The proband's mother is heterozygous for the insertion while the father does not carry the insertion. Multiplex ligation-dependent probe amplification (MLPA) did not identify any deletion encompassing exon 16 in the proband, father or mother. Nonpaternity was excluded using polymorphic markers from several chromosomes. Haplotype analysis using markers spanning chromosome 4 revealed heterodisomy (two homologous chromosomes) of 4p and the distal part of 4q, and isodisomy (duplication of one chromosome) of 4q12-4q26.
CONCLUSION: These data show that the cause of ABL in one of the patients is a missense mutation, p.P552L, while the cause of ABL in the other patient is due to uniparental disomy, probably resulting from non-disjunstion in meiosis I.
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Pujantell, Graell Maria. "Molecular basis of innate immune activation pathways as regulators of susceptibility and clinical evolution of viral infections." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670741.
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El sistema immune innat és el primer en respondre davant patògens que amenacen l’hoste. La resposta immune innata es caracteritza per induir una activació immune innata, iniciar la senyalització d’IFNs i activar vies inflamatòries que generen un estat antiviral capaç de limitar la propagació de patògens i induir la mort cel·lular de cèl·lules afectades.
La identificació de factors de restricció del VIH, com SAMHD1, ha proporcionat coneixements que han relacionat el metabolisme dels nucleòtids, l’activació immune innata i la patogènesi del virus. Per tant, aquesta tesi avalua la relació entre factors virals i de l’hoste que poden afectar la regulació del sistema immune innat i activació de vies d’interferó on potencialment poden controlar la replicació viral i progressió de malalties associades.
Gràcies a l’estudi in-vitro de la infecció del VIH, hem identificat que el virus indueix un mecanisme antiviral innat associat a la producció d’interferó de tipus I i activació de gens estimulats per interferó (ISGs). D’altra banda, el VIH indueix una aturada en el cicle cel·lular a la fase G2/M, mediada per p21, que causa un augment en els nivells de mort cel·lular en macròfags derivats de monòcits (MDMs). D’altra banda, la proteïna accessòria Vpx de VIH-2/SIV, té com a objectiu disminuir l’expressió de SAMHD1 i TASOR. Al mateix temps, Vpx inicia una cascada de senyalització d’activació immune innata caracteritzada per la inducció d’IFNs i expressió d’ISGs que poden ser claus en el disseny d’estratègies dirigides a la reactivació latent del VIH.
El descobriment que mutacions en SAMHD1 i TREX1 estan associades a la malaltia autoimmune del síndrome d’Aicardi-Goutières (AGS) i el fet que ambdós gens tinguin un paper en la replicació del VIH, suggereix que la avaluació de sensors d’àcid nucleic en base a AGS pot potencialment identificar factors de l’hoste que regulen la replicació viral. De fet, un cribratge de gens d’AGS en macròfags primaris ha identificat ADAR1 com un regulador negatiu de la via de senyalització RLR-MAVS que contribueix a l’activació immune innata i la producció d’IFNs. Les cèl·lules on s’ha disminuït l’expressió d’ADAR1 mostren un augment de l’expressió de sensors d’ARN com MDA5 i RIG-I, un augment en la fosforilació del factor de transcripció IRF7 i un augment en la producció d’IFNs de tipus I. L’avaluació in-vitro d’ADAR1, ha mostrat que ADAR1 té un efecte proviral davant el VIH o antiviral davant de VHC i VPH, suggerint que el rol d’ADAR1 depèn de la combinació específica entre virus i hoste. Finalment, les variacions genètiques d’ADAR1 in-vivo s’associen a mal pronòstic clínic i afecten a la resposta del tractament i a la progressió de la malaltia.
En resum, aquesta tesi demostra que la disfunció en vies de detecció d’àcids nucleics intracel·lulars, que desencadenen a una forta activació immune innata i les signatures IFN, són prometedores pel disseny de noves estratègies terapèutiques que tenen com a objectiu modular la replicació viral, alterar la progressió de la malaltia i afectar el resultat final de la infecció.El sistema inmune innato es el primero en responder ante patógenos que amenazan el huésped. La respuesta inmune innata se caracteriza por inducir una activación inmune innata, iniciar la señalización de IFNs y activar vías inflamatorias que generan un estado antiviral capaz de limitar la propagación del patógeno e inducir la muerte celular de células afectadas. La identificación de factores de restricción del VIH, como SAMHD1, ha proporcionado conocimientos que han relacionado el metabolismo de los nucleótidos, la activación inmune innata y la patogénesis del virus. Por lo tanto, esta tesis quiere evaluar la relación entre factores virales y del huésped que pueden afectar a la regulación del sistema inmune innato y activación de vías de interferón donde potencialmente pueden controlar la replicación viral y progresión de enfermedades asociadas. Gracias al estudio in-vitro de la infección del VIH, hemos identificado que el virus induce un mecanismo antiviral innato asociado a la producción de interferón de tipo I y activación de genes estimulados por interferón (ISGs). Por otra parte, el VIH induce una parada en el ciclo celular en la fase G2 / M, mediada por p21, que causa un aumento en los niveles de muerte celular en macrófagos derivados de monocitos (MDMS). Por otra parte, la proteína accesoria Vpx de VIH-2/SIV, tiene como objetivo disminuir la expresión de SAMHD1 y TASOR. Al mismo tiempo, VPX inicia una cascada de señalización de activación inmune innata caracterizada por la inducción de IFNs y expresión de ISGs que pueden ser claves en el diseño de estrategias dirigidas a la reactivación latente del VIH. El descubrimiento que mutaciones en SAMHD1 y TREX1 están asociadas a la enfermedad autoinmune del síndrome de Aicardi-Goutières (AGS) y el hecho de que ambos tengan un papel en la replicación del VIH, sugiere que la evaluación de sensores de ácido nucleico en base a AGS puede potencialmente identificar factores del huésped que regulan la replicación viral. De hecho, un cribado de genes de AGS en macrófagos primarios ha identificado ADAR1 como un regulador negativo de la vía de señalización RLR-MAVS que contribuye a la activación inmune innata y la producción de IFNs. Las células donde se ha disminuido la expresión de ADAR1 muestran un aumento de la expresión de sensores de ARN como MDA5 y RIG-I, un aumento en la fosforilación del factor de transcripción IRF7 y un aumento en la producción de IFNs de tipo I. La evaluación in-vitro de ADAR1, ha mostrado que ADAR1 tiene un efecto proviral ante el VIH o antiviral ante VHC y VPH, sugiriendo que el rol de ADAR1 depende de la combinación específica entre virus y huésped. Finalmente, las variaciones genéticas de ADAR1 in-vivo se asocian a mal pronóstico clínico y afectan a la respuesta del tratamiento y la progresión de la enfermedad. En resumen, esta tesis demuestra que la disfunción en vías de detección de ácidos nucleicos intracelulares, que desencadenan una fuerte activación inmune innata y patrón de IFNs, son prometedoras para el diseño de nuevas estrategias terapéuticas que tienen como objetivo modular la replicación viral, alterar la progresión de la enfermedad y afectar el resultado final de la infección.
The innate immune system is the first to respond against a pathogen invasion that threatens the host. An innate immune response is characterized by inducing innate immune activation, IFN signaling and inflammatory pathways that generate an antiviral state able to limit pathogen spread and induce cell death of damaged cells. The identification of HIV host restriction factors, such as SAMHD1, has provided insights linking nucleotide metabolism, innate immune activation and viral pathogenesis. Hence, this thesis evaluates the relationship between viral and host factors that strongly affect innate immune modulation and IFN pathways that have the potential to alter viral outcome and progression of associated diseases. Through the study of HIV infection, we have identified that HIV induces an innate antiviral mechanism associated to IFN-I production and interferon stimulated gene activation. Moreover, HIV induces a cell cycle arrest at G2/M mediated by p21 leading to elevated levels of cell death in monocyte derived macrophages. On the other hand, accessory protein Vpx from HIV-2/SIV, which targets the downregulation of SAMHD1 and TASOR, also triggers innate immune activation signatures characterized by induction of IFNs and expression of ISGs which may hold key in designing strategies targeting reactivation of latent HIV. The discovery that mutations in SAMHD1 and TREX1 are associated to autoimmune disease Aicardi-Goutières syndrome (AGS) and the fact that both genes have a role in HIV replication, suggests that evaluation of nucleic acid sensors in AGS may have potential for identifying host factors regulating viral replication. Indeed, a screening of AGS genes in primary macrophages has identified ADAR1 as a negative regulator of RIG-I like receptor RLR-MAVS signaling pathway contributing to innate immune activation and IFN production. ADAR1 downregulated cells show increase expression of RNA sensors, MDA5 and RIG-I, enhanced phosphorylation of transcriptional factor IRF7 and increase type I IFN production. ADAR1 in-vitro evaluation have shown a proviral role in HIV, but an antiviral role in HCV and HPV, suggesting ADAR1 role depends on the specific virus host combination. Finally, ADAR1 in-vivo genetic variations are associated to poor clinical outcomes and affect treatment response and disease progression. In summary, this thesis demonstrates that dysfunction of intracellular nucleic acid sensing pathways that trigger strong innate immune activation and IFN signatures hold promising in the design of novel therapeutic strategies aiming to modulate viral replication and disease progression and infection outcomes.
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Filho, Francisco Silveira Mello. "Restrições às outorgas de direitos de uso dos recursos hídricos em situações de escassez: participação, descentralização e seu uso na bacia hidrográfica dos rios Piracicaba, Capivari e Jundiaí entre os anos de 2014 e 2017." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/106/106132/tde-29052018-141442/.
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A governança da água apresenta-se como caminho e paradigma na implementação de uma gestão descentralizada e participativa capaz de permear, com estes princípios, todas as instâncias e instrumentos de gestão. A outorga de direito de uso da água é um dos instrumentos previstos nas legislações federal e estadual (SP) cuja utilização permite controlar o acesso quantitativo e qualitativo a estes recursos. Concedida em consonância com as normas, critérios e diretrizes previamente estabelecidas, é a outorga que concede o direito e autoriza o uso privativo de bem público de uso comum do povo por particular, isto é, o uso da água. É também por meio da outorga que são disciplinados os usos considerados prioritários, insignificantes e orientada a alocação da água nas Bacias Hidrográficas. Especificamente quanto às diretrizes que orientam sua alocação, destaca-se a função do Plano de Bacia. Elaborado no âmbito dos Comitês de Bacias Hidrográficas, cabe ao Plano de Bacia, também chamado de Plano de Recursos Hídricos, oferecer as bases para a alocação da água, por meio das outorgas de direito, determinando seu parâmetro e comportamento nos diferentes regimes hídricos, incluindo os de agravamento de escassez hídrica. Diante deste contexto, o presente trabalho aprofunda as discussões e busca avaliar as restrições impostas às outorgas na Bacia Hidrográfica dos rios Piracicaba, Capivari e Jundiaí (PCJ) entre 2014 e 2017, seus fundamentos e observância aos princípios da descentralização e da participação. A partir dos elementos que compõe o conceito de governança da água e da contextualização da água no ordenamento jurídico brasileiro, o trabalho analisa, com apoio nas normas vigentes, os elementos e características da outorga de direito de uso da água, bem como sua relação com o Plano e com o Comitê de Bacia. Em seguida, analisa-se o Plano vigente durante o período escolhido em três diferentes dimensões: quanto à composição do Comitê e das Câmaras Técnicas atuantes em sua elaboração, quanto ao processo de contratação, elaboração e aprovação e quanto ao seu conteúdo, especialmente na constatação de diretrizes aplicáveis às restrições incidentes sobre as outorgas em períodos de agravamento da escassez. São também analisadas as atuações da Agência Nacional de Águas (ANA) e do Departamento de Águas e Energia Elétrica do Estado de São Paulo (DAEE) e as restrições estabelecidas, por meio de atos normativos, e que incidiram sobre outorgas entre os anos de 2014 e 2017. Constata-se, ao fim, o pequeno envolvimento do Comitê na elaboração do Plano de Bacia vigente à época, a lacuna de seu conteúdo no tratamento de situações críticas e emergenciais e a centralização da concepção das medidas de restrição das outorgas de direitos de uso na bacia dos rios PCJ, restrições estas que se mostram incompatíveis com as diretrizes do quadro normativo vigente.Water governance presents itself as a path and paradigm in the implementation of a decentralized and participative management that is capable to permeate, with these principles, all the instances and instruments. The water grant is one of the instruments provided by the federal and state (SP) laws, which allows to control quantitative and qualitatively the access to these resources. When granted in accordance to the regulatory standards, criteria and guidelines previously established, the water grant guarantees the right and authorizes the private use of a commonweal by particular, that is, the use of water. It is also through the water grant that uses are disciplined according to its priority, meaningless and the water allocation is oriented in the River Basins. Specifically regarding the guidelines that lead its allocation, the function of the Basin Plan is highlighted. Being repared in the scope of the River Basins Committees, it is the responsibility of the Basin Plan, also called as Water Resources Plan, to provide the basis for the water allocation, by the water grant, defining its parameters and behavior in the different water polities, including those of water shortage aggravation. In the view of this context, the current research deepens the discussions and seeks to evaluate the restrictions imposed to the water grant on Piracicaba, Capivari and Jundiaí (PCJ) the River Basin between 2014 and 2017, its foundations and compliance with the principles of decentralization and establishment. Based on the elements that make up the concept of water governance and the contextualization of water in the Brazilian legal system, the research analyzes, with the support of current regulatory standards, the elements and characteristics of water grant, as well as its relation with the Plan and Basin Committee. Afterwards, the current Plan is analyzed according to the selected period in three different dimensions: in regards of composition of the Committee and the Technical Chambers involved in its elaboration, contracting process, elaboration and approval and its content, especially in the verification of the applicable guidelines to restrictions on concessions of water grant in times of shortages aggravation. It is also analyzed the actions taken by the National Water Agency (ANA) and the Department of Water and Electric Energy of the State of São Paulo (DAEE) and the restrictions established, through normative acts, and that affects the water grants between 2014 and 2017. Finally, it is possible to verify the little involvement of the Committee in the Basin Plan elaboration in force at the time, lacks of its content in the treatment of critical and emergency situations, and the centralization in the conception of the restricting measures of the water grant in the PCJ river basins, restrictions that are shown incompatible with the guidelines of the current regulatory framework.
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Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.
Full textAbstract:
L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2 és capaç d'inhibir la mort causada per l'activació sostinguda de Hog1.També hem observat que la mort cel·lular causada per l'activació sostinguda de Hog1 és deguda a una inducció d'apoptosi. L'apoptosi induïda per Hog1 és inhibida per la mutació al complexe SCFCDC4. Per tant, la via d'extensió de la vida és capaç de prevenir l'apoptosi a través d'un mecanisme desconegut.
Sustained Hog1 activation leads to an inhibition of cell growth. In this work, we have observed that the lethal phenotype caused by sustained Hog1 activation is prevented by SCFCDC4 mutants. The prevention of Hog1-induced cell death by SCFCDC4 mutation depends on the lifespan extension pathway. Upon sustained Hog1 activation, SCFCDC4 mutation increases Msn2 and Msn4 dependent gene expression that leads to a PNC1 overexpression and a Sir2 deacetylase hyperactivation. Then, hyperactivation of Sir2 is able to prevent cell death caused by sustained Hog1 activation.
We have also observed that cell death upon sustained Hog1 activation is due to an induction of apoptosis. The apoptosis induced by Hog1 is decreased by SCFCDC4 mutation. Therefore, lifespan extension pathway is able to prevent apoptosis by an unknown mechanism.
Books on the topic "Basin restriction"
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Basic Handbook on the Essentials of EU Competition Law. Madrid: Dykinson, 2015.
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United States. Bureau of Land Management., United States. Dept. of Agriculture., United States. Dept. of Energy., United States. Energy Information Administration., and Geological Survey (U.S.), eds. Scientific inventory of onshore Federal lands' oil and gas resources and the extent and nature of restrictions or impediments to their development: Phase II cumulative inventory : northern Alaska, Montana Thrust Belt, Powder River Basin, Wyoming Thrust Belt, greater Green River Basin, Denver Basin, Uinta-Piceance Basin, Paradox/San Juan Basins, Appalachian Basin, Black Warrior Basin, Florida Peninsula. [Washington, D.C: U.S. Dept. of the Interior, Bureau of Land Management,], 2006.
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Hudson, William J. The basic mechanisms of Japanese farm policy: Illustrated by rice price support and beef import restrictions : how they work. Washington, D.C.?]: U.S. Dept. of Agriculture, Economic Research Service, 1990.
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Oman's basic statute and human rights: Protections and restrictions : with a focus on nationality, shura, and freedom of association. Berlin: Klaus Schwarz Verlag, 2013.
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Hudson, William J. The basic mechanisms of Japanese farm policy: Illustrated by rice price support and beef import restrictions : how they work. [Washington, D.C.?]: U.S. Dept. of Agriculture, Economic Research Service, 1990.
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), National Agricultural Pesticide Impact Assessment Program (U S. The effects of restricting or banning atrazine use to reduce surface water contamination in the Upper Mississippi River Basin: A summary. Washington, D.C.?]: The Program, 1992.
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Ovsyannikov, Evgeniy, and Tamara Gaytova. Optimal control of traction electric drives. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1141767.
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The monograph considers various types of traction electric drives of motor vehicles intended for operation in urban conditions. Mathematical models of these systems are proposed. On the basis of parametric optimization and graphoanalytic method, a method of joint control of electric drives according to the criteria of minimum losses and maximum overload capacity, taking into account possible restrictions on the resources of power elements, has been developed.
For a wide range of readers interested in improving motor vehicles. It will be useful for students, postgraduates and teachers of engineering and technical universities.
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Dubanov, Aleksandr. Computer simulation in pursuit problems. ru: Publishing Center RIOR, 2022. http://dx.doi.org/10.29039/02102-6.
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Currently, computer simulation in virtual reality systems has a special status. In order for a computer model to meet the requirements of the tasks it models, it is necessary that the mathematical apparatus correctly describe the simulated phenomena.
In this monograph, the simulation of pursuit problems is carried out. An adaptive modeling of the behavior of both pursuers and targets is carried out. An iterative calculation of the trajectories of the participants in the pursuit problem is carried out.
The main attention is paid to the methods of pursuit and parallel rendezvous. These methods are taken as the basis of the study and are modified in the future.
The scientific novelty of the study is the iterative calculation of the trajectories of the participants in the pursuit task when moving at a constant speed, while following the predicted trajectories.
The predicted trajectories form a one-parameter network of continuous lines of the first order of smoothness. The predicted trajectories are calculated taking into account the restrictions on the curvature of the participant in the pursuit problem.
The fact of restrictions on curvature can be interpreted as restrictions on the angular frequency of rotation of the object of the pursuit problem.
Also, the novelty is the calculation of the iterative process of group pursuit of multiple targets, when targets are hit simultaneously or at specified intervals. The calculation of the parameters of the network of predicted trajectories is carried out with a curvature variation in order to achieve the desired temporal effect.
The work also simulates the adaptive behavior of the pursuer and the target. The principle of behavior can be expressed on the example of a pursuer with a simple phrase: "You go to the left - I go to the left." This happens at each iteration step in terms of choosing the direction of rotation. For the purpose, the principle of adaptive behavior is expressed by the phrase: "You go to the left - I go to the right."
The studies, algorithms and models presented in the monograph can be in demand in the design of autonomously controlled unmanned aerial vehicles with elements of artificial intelligence.
The task models in the monograph are supplemented with many animated images, where you can see the research process.
Also, the tasks have an implementation in a computer mathematics system and can be transferred to virtual reality systems if necessary.
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United States. Dept. of the Interior., United States. Dept. of Agriculture., United States. Dept. of Energy., United States. Bureau of Land Management., United States. Energy Information Administration., and Geological Survey (U.S.), eds. Scientific inventory of onshore Federal lands' oil and gas resources and reserves and the extent and nature of restrictions or impediments to their development: The Paradox/San Juan, Uinta/Piceance, greater Green River, and Powder River Basins and the Montana Thrust Belt. [Washington, D.C: U.S. Dept. of the Interior, Bureau of Land Management, 2003.
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United States. Bureau of Land Management. Scientific inventory of onshore Federal lands' oil and gas resources and reserves and the extent and nature of restrictions or impediments to their development: The Paradox/San Juan, Uinta/Piceance, greater Green River, and Powder River Basins and the Montana Thrust Belt. [Washington, D.C.]: [U.S. Department of the Interior, Bureau of Land Management], 2003.
Find full textBook chapters on the topic "Basin restriction"
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Wang, Guofeng, Jiancheng Chen, Fuchun Zhang, Xiaoxue Zhou, and Xiangzheng Deng. "Water and Land Effects on Agricultural Development for River Basin: Resource Restriction and Sustainable Development." In River Basin Management, 1–31. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-0841-2_14-1.
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Wang, Guofeng, Jiancheng Chen, Fuchun Zhang, Xiaoxue Zhou, and Xiangzheng Deng. "Water and Land Effects on Agricultural Development for River Basin: Resource Restriction and Sustainable Development." In River Basin Management, 151–82. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-10-6949-9_14.
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Maciel, Carolina, and Bettina Bock. "Animal welfare measures and the WTO Post-EC - seal products case: a renewed debate and research agenda." In The economics of farm animal welfare: theory, evidence and policy, 156–72. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781786392312.0156.
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Abstract For nearly 20 years trade officials and scholars debated whether a national measure restricting trade on the basis of animal welfare concerns could be deemed compliant with the rules of the World Trade Organization (WTO). In June 2014, the dispute settlement body of the WTO adopted the decision on the EC - Seal Products case confirming that trade-restrictive measures aimed at safeguarding the welfare of animals can be deemed necessary to protect citizens' moral concerns. While this decision provides long-awaited answers and insights, it does not exhaust the debate on the obstacles for justifying animal welfare trade restrictions. This paper provides an overview of controversies surrounding the topic of animal welfare from a WTO perspective and a brief review of the findings from the EC - Seal Products case. In addition, this chapter calls for further research on potential controversies that may rise in relation to trade measures in contexts beyond seal hunting; like, for instance, regulatory divergences over farm animal welfare measures. In doing so, it recommends that future research pays special attention to the potential controversies associated with the use of animal welfare recommendations elaborated by the World Organisation for Animal Health (OIE) (OIE, 2019).
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Richardson, Arlan, and Mohammad A. Pahlavani. "Thoughts on the evolutionary basis of dietary restriction." In Genetics and Evolution of Aging, 226–31. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-017-1671-0_19.
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Kaur, Gurcharan, Taranjeet Kaur, Anuradha Sharma, Shaffi Manchanda, Harpal Singh, Shikha Kalotra, and Payal Bajaj. "Intermittent Fasting-Dietary Restriction as a Geroprotector." In Molecular Basis and Emerging Strategies for Anti-aging Interventions, 195–215. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1699-9_13.
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Emmrich, F., G. Zenke, and K. Eichmann. "Isotype Restriction of Idiotopes found on Human Anti-Carbohydrate Antibodies." In The Molecular Basis of B-Cell Differentiation and Function, 45–47. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-7035-2_7.
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Zaporozhets, Oleksandr. "Balanced Approach to Aircraft Noise Management." In Aviation Noise Impact Management, 29–56. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-91194-2_3.
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AbstractICAO Balanced Approach (BA) to aircraft noise management in airports is reviewed in accordance with historical and technological challenges. All four basic elements of the BA are subject to noise exposure control with dominant emphasis on reduction of noise at source and compatible land usage inside the noise zoning around the airports. Noise abatement procedures and flight restrictions are used at any airport due to its specific issues and should be implemented on a basis of cost–benefit analysis. Noise exposure reduction is an intermediate goal, a final goal—to reduce noise impact, which is mostly represented by population annoyance as a reaction to noise exposure, is discussed also.
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Longo, Lawrence D. "Fetal Growth Restriction at High Altitude: Basic Cellular and Subcellular Physiologic Considerations." In The Rise of Fetal and Neonatal Physiology, 435–99. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7483-2_15.
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Naef, Tobias. "Restrictions on Data Transfers and Trade Agreements." In European Yearbook of International Economic Law, 367–420. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-19893-9_5.
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AbstractIn reaction to the stalemate in the multilateral trading system, international governance of digital trade has gradually shifted toward bilateral and regional trade agreements. This allowed countries to start to regulating cross-border flows of personal data outside the WTO framework. The first section of this chapter traces the development of data flow clauses in the trade agreements of the EU, the US, and other countries. It also looks at the negotiations of the big trade agreements in the late 2010s, such as the TTIP, the TiSA, and the TPP (Sect. 5.1). The second section outlines the scope for data flow clauses in the trade agreements of the EU based on different legal requirements stemming from the architecture of EU law, the GDPR, and other regulations. These requirements include the primacy of fundamental rights over international law with regard to the right to continuous protection of personal data in Article 8 CFR, the accommodation of the legal mechanisms for the transfer of personal data in the GDPR, the inclusion of cooperation mechanisms on the basis of Article 50 GDPR, and the ban of data localization requirements beyond data protection and privacy concerns. These legal requirements are necessary to consider when drafting data flow clauses for EU trade agreements (Sect. 5.2). The third section of this chapter offers and analyzes four potential designs for data flow clauses for EU trade agreements (Sect. 5.3). The fourth section is dedicated to the analysis of the EU model data flow clauses that the European Commission introduced as a template for future trade negotiations in 2018 (Sect. 5.4).
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Frank, Wijckmans, and Tuytschaever Filip. "Part II Vertical Agreements Under Regulation 330/2010, 6 Article 4: Hardcore Restrictions." In Vertical Agreements in EU Competition Law. Oxford University Press, 2018. http://dx.doi.org/10.1093/law-ocl/9780198791027.003.0006.
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This chapter addresses the hardcore restrictions which are included in Article 4 of Regulation 330/2010. Once it has been established that a vertical agreement falls within the scope of application of Regulation 330/2010, complies with the limitations included in Article 2(2)–(5), and does not exceed the market share limits, the next step is to check whether it contains any hardcore restrictions. This assessment constitutes the eleventh step of the analysis.The hardcore restrictions consist of RPM and certain territorial and customer restrictions. For the purposes of Regulation 330/2010, the list of hardcore restrictions in Article 4 is exhaustive. The inclusion of a hardcore restriction renders the block exemption inapplicable to the vertical agreement as a whole. In addition, the Vertical Guidelines provide for a rebuttable presumption that a hardcore restriction will fail to meet the conditions of Article 101(3) TFEU on an individual basis (self-assessment).
Conference papers on the topic "Basin restriction"
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Putranta, Dinariyana Dwi, Ketut Buda Artana, Kriyo Sambodho, and I. Made Ariana. "Risk Assessment on Subsea Gas Pipelines Located at Water Basin of Jetty Area due to Dredging and Operation After Dredging." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10358.
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This study addresses risk assessment of 14″ gas pipelines buried closed to jetty area due to the plan to dredge the water basin at jetty area. The dredging plan is aimed to enable a more spacious maneuvering basin at the jetty area to enable larger vessel to be served and easier control of tug boat operation during berthing process. Before dredging, the gas pipeline is located 133 m from the slope. This condition provides enough protection to the gas pipeline since large vessel will not reach the pipeline due to vessel’s draft restriction. After dredging, however, gas pipeline will be located only 49 m away from the slope. The water area after dredging allows larger vessel will be in the vicinity of the pipeline and hence impose risk to the existence of the gas pipeline. Risk to the pipelines due to dredging activities (drop/drag anchor, drop clamshell/object, ship sinking, and ground instability) and due to various vessels operation after dredging (drop/drag anchor, ship sinking, and ship grounding) are assessed by implementing quantitative risk assessment. Hence, this study is focused on the assessment of risk to the 14″ gas pipeline due to dredging activity including risk assessment during operation of the jetty after dredging. Based on pipeline and environmental data, all possible hazards are identified. Some hazards are screened out using ‘Failure Modes and Effects Analysis’ (FMEA) to obtain the list of potential hazards. In order to evaluate the acceptance criteria of all potential risks, the risk profiles are composed according to DNV-RP-F107 “Risk Assessment of Pipeline Protection”. As part of the assessment, geotechnical assessments of submarine landslide due to dredging are also considered. The effective stress approach is implemented to the assessment and submarine slope stability is analyzed using Bishop’s and Janbu’s methods of analysis. The risk profiles for all potential hazards are reported, and simulation results for different slope ratios are given to illustrate the stability of slope configuration during dredging.
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Hyden, Ron E., and Neil A. Stegent. "Pump-in/Shutdown Tests Key to Finding Near-WelIbore Restrictions." In Permian Basin Oil and Gas Recovery Conference. Society of Petroleum Engineers, 1996. http://dx.doi.org/10.2118/35194-ms.
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Torres, Sergio. "Restrictions on cosmological models placed by COBE’s measurement of cosmic background anisotropies." In Basic space science. AIP, 1995. http://dx.doi.org/10.1063/1.46997.
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Zhang, Ying, Zhigang Kan, and Dongyu Qu. "Basis of Advanced Ergonomics in Restriction Product Design." In 2022 IEEE International Conference on Mechatronics and Automation (ICMA). IEEE, 2022. http://dx.doi.org/10.1109/icma54519.2022.9856331.
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Baptista, Renan Martins, and Andre´ Luiz Guedes Maricato. "The Merluza Gas Pipeline: A Complete Multiphase Flow Analysis Coupling Pig Launching With Pressure Constrained Survival Analysis." In 2004 International Pipeline Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ipc2004-0118.
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This work describes the requirements and comments the results of a set of pipeline flow numerical simulations, for the offshore Merluza wet gas pipeline, located at Santos Basin, state of Sa˜o Paulo, Brazil. The work was conceived under the two-phase flow domain, and has used a well known commercial two phase flow numerical simulator. This pipeline is somewhat singular when compared to the average wet gas pipeline, as there is a considerable amount of condensate being carried, requiring a frequent launching of pigs. Besides, the capacity request at the pipeline’s tail is variable, even though it fits to an approximate stable cycle of demand. This cycling nature has required a survival analysis, for both packing and drafting operations, accounting for sometimes four pigs within the line, at the same time. Additionally, there is a pressure constraint downstream to the pipeline, due to the operational limits of the slug catcher, turning compulsory to have the survival cycle adjusted, in order to fully commit to this restriction. Finally, the results obtained with the simulation fits properly to the measured operational data, and allows the operational programmer to optimize the launching of pigs, as well as to take advantage of the maximum pipeline capacity.
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Møyner, O., and H. Tchelepi. "A Multiscale Restriction-Smoothed Basis Method for Compositional Models." In SPE Reservoir Simulation Conference. Society of Petroleum Engineers, 2017. http://dx.doi.org/10.2118/182679-ms.
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Bueno, Paulo M. S., Plínio R. S. Vilela, Luciano M. Christofoletti, and Anderson P. Vieira. "Optimizing Railway Track Maintenance Scheduling to Minimize Circulation Impacts." In 2019 Joint Rail Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/jrc2019-1298.
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1 In this paper we present an optimization based technique to allocate time windows for railroad track maintenance in order to minimize the impact on train circulation. The hypothesis is that it is possible to reduce the impact on train circulation if track maintenance slots are scheduled in naturally occurring gaps on the circulation, instead of just using a decision making process that does not take the train circulation into consideration. The proposed solution uses simulated annealing as the basis for the algorithm and yields promising results when a random initial placement of track blocks is used. We show the results of our experiments that consider as restrictions the earliest initial time for the track block and the latest termination time for the track blocks (to account for restriction in crew work hours, for example). For this work we do not restrict the number of simultaneous maintenance teams that could be working, future investigations will account for that restriction.
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Liorni, Ilaria, Myles Capstick, Sven Kuehn, and Niels Kuster. "Novel Approach for Compliance Testing of WPT Systems with Basic Restrictions." In 2018 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2018. http://dx.doi.org/10.1109/wpt.2018.8639099.
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Manea, A. M. "A Massively Parallel Restriction-Smoothed Basis Multiscale Solver on Multicore and GPU Architectures." In SPE Reservoir Simulation Conference. SPE, 2021. http://dx.doi.org/10.2118/203939-ms.
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Abstract Due to its simplicity, adaptability, and applicability to various grid formats, the restriction-smoothed basis multiscale method (MsRSB) (Møyner and Lie 2016) has received wide attention and has been extended to various flow problems in porous media. Unlike the standard multiscale methods, MsRSB relies on iterative smoothing to find the multiscale basis functions in an adaptive manner, giving it the ability to naturally adjust to various complex grid orientations often encountered in real-life industrial applications. In this work, we investigate the scalability of MsRSB on various state-of-the-art parallel architectures, including multicore systems and GPUs. While MsRSB is-like most other multiscale methods-directly amenable to parallelization, the dependence on a smoother to find the basis functions creates unique control- and data-flow patterns. These patterns require careful design and implementation in parallel environments to achieve good scalability. We extend the work on parallel multiscale methods in Manea et al. (2016) and Manea and Almani (2019) to map the MsRSB special kernels to the shared-memory parallel multicore and GPU architectures. The scalability of our optimized parallel MsRSB implementation is demonstrated using highly heterogeneous 3D problems derived from the SPE10 Benchmark (Christie and Blunt 2001). Those problems range in size from millions to tens of millions of cells. The multicore implementation is benchmarked on a shared memory multicore architecture consisting of two packages of Intel® Cascade Lake Xeon® Gold 6246 CPU, while the GPU implementation is benchmarked on a massively parallel architecture consisting of NVIDIA Volta V100 GPUs. We compare the multicore implementation to the GPU implementation for both the setup and solution stages. Finally, we compare our parallel MsRSB scalability to the scalability of the parallel algebraic multiscale solver (AMS) on multicore (Manea et al. 2016) and GPU (Manea and Almani 2019) architectures. To the best of our knowledge, this is the first parallel implementation and demonstration of the versatile MsRSB method on the GPU architecture.
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Chen, Cheng-Hsien, Yuan Kang, Yeon-Pun Chang, De-Xing Peng, and Ding-Wen Yang. "Influences of Recess Geometry and Restrictor Dimension on Flow Patterns and Pressure Distribution of Hydrostatic Bearings." In ASME Turbo Expo 2007: Power for Land, Sea, and Air. ASMEDC, 2007. http://dx.doi.org/10.1115/gt2007-28219.
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This paper studies the influences of recess geometry and restrictor dimensions on the flow patterns and pressure distribution of lubricant film, which are coupled effects of hybrid characteristics of a hydrostatic bearing. The lubricant flow is described by using the Navier-Stokes equations. The Galerkin weighted residual finite element method is applied to determine the lubricant velocities and pressure in the bearing clearance. The numerical simulations will evaluate the effects of the land-width ratio and restriction parameter as well as the influence of modified Reynolds number and the jet-strength coefficient on the flow patterns in the recess and pressure distribution in lubricant film. On the basis of the simulation drawn from this study, the simulated results are expected to help engineers make better use of the design of hydrostatic bearing and its restrictors.
Reports on the topic "Basin restriction"
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Baader, Franz, Carsten Lutz, Eldar Karabaev, and Manfred Theißen. A New n-ary Existential Quantifier in Description Logics. Technische Universität Dresden, 2005. http://dx.doi.org/10.25368/2022.151.
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Motivated by a chemical process engineering application, we introduce a new concept constructor in Description Logics (DLs), an n-ary variant of the existential restriction constructor, which generalizes both the usual existential restrictions and so-called qualified number restrictions. We show that the new constructor can be expressed in ALCQ, the extension of the basic DL ALC by qualified number restrictions. However, this representation results in an exponential blow-up. By giving direct algorithms for ALC extended with the new constructor, we can show that the complexity of reasoning in this new DL is actually not harder than the one of reasoning in ALCQ. Moreover, in our chemical process engineering application, a restricted DL that provides only the new constructor together with conjunction, and satisfies an additional restriction on the occurrence of roles names, is sufficient. For this DL, the subsumption problem is polynomial.
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Baader, Franz. Terminological cycles in a description logic with existential restrictions. Technische Universität Dresden, 2002. http://dx.doi.org/10.25368/2022.120.
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Cyclic definitions in description logics have until now been investigated only for description logics allowing for value restrictions. Even for the most basic language FL₀, which allows for conjunction and value restrictions only, deciding subsumption in the presence of terminological cycles is a PSPACE-complete problem. This report investigates subsumption in the presence of terminological cycles for the language EL, which allows for conjunction and existential restrictions. In contrast to the results for FL₀, subsumption in EL remains polynomial, independent of wether we use least fixpoint semantics, greatest fixpoint semantics, or descriptive semantics. These results are shown via a characterization of subsumption through the existence of certain simulation relations between nodes of the description graph associated with a given cyclic terminology.
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Baumeister, Christiane, and James Hamilton. Drawing Conclusions from Structural Vector Autoregressions Identified on the Basis of Sign Restrictions. Cambridge, MA: National Bureau of Economic Research, January 2020. http://dx.doi.org/10.3386/w26606.
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Read, Matthew. Estimating the Effects of Monetary Policy in Australia Using Sign-restricted Structural Vector Autoregressions. Reserve Bank of Australia, January 2023. http://dx.doi.org/10.47688/rdp2022-09.
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Existing estimates of the macroeconomic effects of Australian monetary policy tend to be based on strong, potentially contentious, assumptions. I estimate these effects under weaker assumptions. Specifically, I estimate a structural vector autoregression identified using a variety of sign restrictions, including restrictions on impulse responses to a monetary policy shock, the monetary policy reaction function, and the relationship between the monetary policy shock and a proxy for this shock. I use an approach to Bayesian inference that accounts for the problem of posterior sensitivity to the choice of prior that arises in this setting, which turns out to be important. Some sets of identifying restrictions are not particularly informative about the effects of monetary policy. However, combining the restrictions allows us to draw some useful inferences. There is robust evidence that an increase in the cash rate lowers output and consumer prices at horizons beyond a year or so. The results are consistent with the macroeconomic effects of a 100 basis point increase in the cash rate lying towards the upper end of the range of existing estimates.
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Redmond, Paul, Seamus McGuinness, and Klavs Ciprikis. A universal basic income for Ireland: Lessons from the international literature. ESRI, December 2022. http://dx.doi.org/10.26504/rs146.
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A universal basic income (UBI) is defined as a universal, unconditional cash payment that is made regularly, is sufficient to live on, is not means tested, carries no work requirements and is paid on an individual basis. This study examines the international evidence on universal basic incomes and identifies key issues for consideration in the design of any UBI pilot for Ireland. Despite the mainstream interest in UBI as a potential policy tool, relatively little is known about the associated consequences of such policies. Even the definition of a UBI appears to be poorly understood and is often misused in the public discourse. Several pilot studies have been recently implemented across different countries. However, some pilot studies depart from the accepted definition of UBI. For example, some are not universal, in that they only target a specific subgroup of the population and/or have eligibility restrictions based on earnings. Others provide a relatively low level of payment, which may fall short of what an individual could reasonably be expected to live on. There are a number of potentially positive impacts associated with a UBI. A universal, unconditional payment could eliminate the stigma associated with welfare receipt. If replacing existing welfare payments, a UBI would also involve lower transaction costs, both on the recipient (in terms of the application procedure) and on Government (in terms of administering the payment). Universal, unconditional payments would also avoid situations where people choose not to work in order to retain means-tested benefits. UBI could give individuals the freedom to turn down or leave insecure, exploitative or low-paid work in pursuit of better or improved work opportunities. In addition, it would mean that persons in informal and often unpaid work, such as childcare and eldercare, which is mostly done by women, receive some compensation for their labour. Empirical results from several pilot studies have found evidence of positive health impacts following the implementation of a UBI. In terms of potential disadvantages, a UBI, by definition, may not target those that are most in need, as a large percentage of recipients will be high-earning individuals. Furthermore, the cost of a UBI is likely to be very expensive, even if other existing benefits (such as unemployment benefits) are no longer required. The net impacts of a UBI on labour supply are unclear, with both positive and negative influences on labour market participation potentially arising as a consequence of a UBI. In this study, we undertake some basic calculations relating to four possible UBI approaches, all of which would involve an unconditional payment to every individual aged over 18 in Ireland.
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Brandt, Sebastian, Anni-Yasmin Turhan, and Ralf Küsters. Foundations of non-standard inferences for DLs with transitive roles. Technische Universität Dresden, 2003. http://dx.doi.org/10.25368/2022.127.
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Description Logics (DLs) are a family of knowledge representation formalisms used for terminological reasoning. They have a wide range of applications such as medical knowledge-bases, or the semantic web. Research on DLs has been focused on the development of sound and complete inference algorithms to decide satisfiability and subsumption for increasingly expressive DLs. Non-standard inferences are a group of relatively new inference services which provide reasoning support for the building, maintaining, and deployment of DL knowledge-bases. So far, non-standard inferences are not available for very expressive DLs. In this paper we present first results on non-standard inferences for DLs with transitive roles. As a basis, we give a structural characterization of subsumption for DLs where existential and value restrictions can be imposed on transitive roles. We propose sound and complete algorithms to compute the least common subsumer (lcs).
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Baader, Franz, and Benjamin Zarrieß. Verification of Golog Programs over Description Logic Actions. Technische Universität Dresden, 2013. http://dx.doi.org/10.25368/2022.198.
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High-level action programming languages such as Golog have successfully been used to model the behavior of autonomous agents. In addition to a logic-based action formalism for describing the environment and the effects of basic actions, they enable the construction of complex actions using typical programming language constructs. To ensure that the execution of such complex actions leads to the desired behavior of the agent, one needs to specify the required properties in a formal way, and then verify that these requirements are met by any execution of the program. Due to the expressiveness of the action formalism underlying Golog (situation calculus), the verification problem for Golog programs is in general undecidable. Action formalisms based on Description Logic (DL) try to achieve decidability of inference problems such as the projection problem by restricting the expressiveness of the underlying base logic. However, until now these formalisms have not been used within Golog programs. In the present paper, we introduce a variant of Golog where basic actions are defined using such a DL-based formalism, and show that the verification problem for such programs is decidable. This improves on our previous work on verifying properties of infinite sequences of DL actions in that it considers (finite and infinite) sequences of DL actions that correspond to (terminating and non-terminating) runs of a Golog program rather than just infinite sequences accepted by a Büchi automaton abstracting the program.
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Anderson, Olin, and Gad Galili. Development of Assay Systems for Bioengineering Proteins that Affect Dough Quality and Wheat Utilization. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568781.bard.
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The quality and utilization of wheat is largely dependent upon the exact physical/chemical properties of the doughs made from flour/water mixtures. Among the wheat seed components most correlated with dough visoelastic parameters are the high-molecular-weight (HMW) glutenin subunits whose disulfide cross-linked macropolymer is critical for dough functionality. We have used the tools of molecular biology, wheat transformation, heterologous expression of HMW-glutenin subunits in bacteria, and dough micro-mixing experiments to examine some of the molecular basis of HMW-glutenin functionality. In addition, we have developed sets of modified and synthetic gene constructs and transgenic wheat lines that will allow further examination of the role of the HMW-glutenins. Among the results from this work is evidence that the HMW-glutenin repeat domain is directly related to dough properties, the demonstration that interaction between subunits is dependent upon domain presence but not order, a novel understanding of the restrictions on intra-vs inter-chain disulfide bonds, the demonstration that HMW-glutenin genes can be transformed into wheat for simultaneously high expression of the transgene and suppression of the endogenous genes, and the construction of a set of modified HMW-glutenins capable of being epitope tagged for studying polypeptide subcellular processing and the fate of HMW-glutenins in dough mixing experiments.
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Levisohn, Sharon, Mark Jackwood, and Stanley Kleven. New Approaches for Detection of Mycoplasma iowae Infection in Turkeys. United States Department of Agriculture, February 1995. http://dx.doi.org/10.32747/1995.7612834.bard.
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Mycoplasma iowae (Mi) is a pathogenic avian mycoplasma which causes mortality in turkey embryos and as such has clinical and economic significance for the turkey breeder industry. Control of Mi infection is severely hampered by lack of adequate diagnostic tests, together with resistance to most antibiotics and resilience to environment. A markedly high degree of intra-species antigenic variation also contributes to difficulties in detection and control of infection. In this project we have designed an innovative gene-based diagnostic test based on specific amplification of the 16S rRNA gene of Mi. This reaction, designed Multi-species PCR-RFLP test, also amplifies the DNA of the pathogenic avian mycoplasmas M. gallisepticum (Mg) and M. synoviae (Ms). This test detects DNA equivalent to about 300 cfu Mi or either of the other two target mycoplasmas, individually or in mixed infection. It is a quick test, applicable to a wide variety of clinical samples, such as allantoic fluid or tracheal or cloacal swab suspensions. Differential diagnosis is carried out by gel electro-phoresis of the PCR amplicon digested with selected restriction enzymes (Restriction Fragment Length Polymorphism). This can also be readily accomplished by using a simple Dot-Blot hybridization assay with digoxigenin-labeled oligonucleotide probes reacting specifically with unique Mi, Mg or Ms sequences in the PCR amplicon. The PCR/OLIGO test increased sensitivity by at least 10-fold with a capacity for rapid testing of large numbers of samples. Experimental infection trials were carried out to evaluate the diagnostic tools and to study pathogenesis of Mi infection. Field studies and experimental infection of embryonated eggs indicated both synergistic and competitive interaction of mycoplasma pathogens in mixed infection. The value of the PCR diagnostic tests for following the time course of egg transmission was shown. A workable serological test (Dot Immunobinding Assay) was also developed but there was no clear-cut evidence that infected turkeys develop an immune response. Typing of a wide spectrum of Mi field isolates by a variety of gene-based molecular techniques indicated a higher degree of genetic homogeneity than predicted on the basis of the phenotypic variability. All known strains of Mi were detected by the method developed. Together with an M. meleagridis-PCR test based on the same gene, the Multi-species PCR test is a highly valuable tool for diagnosis of pathogenic mycoplasmas in single or mixed infection. The further application of this rapid and specific test as a part of Mi and overall mycoplasma control programs will be dependent on developments in the turkey industry.
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Yatsymirska, Mariya. KEY IMPRESSIONS OF 2020 IN JOURNALISTIC TEXTS. Ivan Franko National University of Lviv, March 2021. http://dx.doi.org/10.30970/vjo.2021.50.11107.
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The article explores the key vocabulary of 2020 in the network space of Ukraine. Texts of journalistic, official-business style, analytical publications of well-known journalists on current topics are analyzed. Extralinguistic factors of new word formation, their adaptation to the sphere of special and socio-political vocabulary of the Ukrainian language are determined. Examples show modern impressions in the media, their stylistic use and impact on public opinion in a pandemic. New meanings of foreign expressions, media terminology, peculiarities of translation of neologisms from English into Ukrainian have been clarified. According to the materials of the online media, a «dictionary of the coronavirus era» is provided. The journalistic text functions in the media on the basis of logical judgments, credible arguments, impressive language. Its purpose is to show the socio-political problem, to sharpen its significance for society and to propose solutions through convincing considerations. Most researchers emphasize the influential role of journalistic style, which through the media shapes public opinion on issues of politics, economics, education, health care, war, the future of the country. To cover such a wide range of topics, socio-political vocabulary is used first of all – neutral and emotionally-evaluative, rhetorical questions and imperatives, special terminology, foreign words. There is an ongoing discussion in online publications about the use of the new foreign token «lockdown» instead of the word «quarantine», which has long been learned in the Ukrainian language. Research on this topic has shown that at the initial stage of the pandemic, the word «lockdown» prevailed in the colloquial language of politicians, media personalities and part of society did not quite understand its meaning. Lockdown, in its current interpretation, is a restrictive measure to protect people from a dangerous virus that has spread to many countries; isolation of the population («stay in place») in case of risk of spreading Covid-19. In English, US citizens are told what a lockdown is: «A lockdown is a restriction policy for people or communities to stay where they are, usually due to specific risks to themselves or to others if they can move and interact freely. The term «stay-at-home» or «shelter-in-place» is often used for lockdowns that affect an area, rather than specific locations». Content analysis of online texts leads to the conclusion that in 2020 a special vocabulary was actively functioning, with the appropriate definitions, which the media described as a «dictionary of coronavirus vocabulary». Media broadcasting is the deepest and pulsating source of creative texts with new meanings, phrases, expressiveness. The influential power of the word finds its unconditional embodiment in the media. Journalists, bloggers, experts, politicians, analyzing current events, produce concepts of a new reality. The world is changing and the language of the media is responding to these changes. It manifests itself most vividly and emotionally in the network sphere, in various genres and styles.