Dissertations / Theses on the topic 'Basic Helix loop Helix (bHLH)'
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Zhang, Fan. "Cloning and characterization of genes encoding basic helix loop helix (bHLH) proteins in Arabidopsis /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992950.
Full textSaarikettu, Juha. "Calcium regulation and functions of basic Helix-Loop-Helix transcription factors." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-537.
Full textZhou, Shengli. "ZNF451 is a novel binding partner of the bHLH transcription factor E₁₂." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1225219996.
Full text"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 49-62.
Kele, Olovsson Julianna M. V. "Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins/." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-242-2/.
Full textBrockop, Mia. "Twist1 and Tcf12 interaction is critical for the development of the coronal suture in human and mouse." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112195/document.
Full textCraniosynostosis, the premature fusion of one or more cranial sutures, is a common birth defect (1/2500 live births) that results in abnormalities in skull shape and sometimes in neurological deficiencies (Wilkie, 1997; Wilkie and Morriss-Kay, 2001). Mutations in TWIST1, which encodes a class II basic helix-loop-helix (bHLH) transcription factor, cause Saethre-Chotzen syndrome, associated with coronal synostosis (El Ghouzzi et al. 1997; Howard et al. 1997). We recently discovered a new craniosynostosis gene, TCF12, which encodes a class I bHLH transcription factor. Tcf12 causes.Saethre-Chotzen syndrome and asyndromic coronal synostosis. (Sharma, Fenwick, Brockop, et al., 2013). We show that a reduction in the dosage of Twist1 and Tcf12 in mouse causes coronal synostosis, and we suggest that the Twist1 and Tcf12 form heterodimers whose dosage is critical for coronal suture development. We also demonstrate that Twist1 is required in both neural-crest and mesoderm-derived tissues for the normal coronal suture development. Moreover, we show that in the coronal suture, Twist1 excludes Notch2 thus maintaining suture patency. and we show that beta-catenin also plays a role in the maintenance of suture patency by regulating Jagged1. Finally, we identified Aggrecan, Goosecoid, Gucy1a3 and Gucy1b3 as Twist1-regulated genes that could have an impact on the normal development of the coronal suture
Rosenberg, Miriam Isaaca. "Diverse mechanisms employed by bHLH transcription factors to downregulate gene expression /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/5016.
Full textGrove, Christian A. "A Multiparameter Network Reveals Extensive Divergence Between C. elegans bHLH Transcription Factors: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/441.
Full textMao, Weiming. "The role of bHLH gene ash1 in the developing chick eye." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/mao.pdf.
Full textSerre, Angéline. "Stratégies d'homogénéisation des populations de progéniteurs nerveux fœtaux humains dans une perspective de thérapie cellulaire du système nerveux central." Paris 6, 2007. https://tel.archives-ouvertes.fr/tel-00184239.
Full textMartin, Nathalie. "Studies on the regulation of the Napin napA promoter by ABI3, bZIP and bHLH transcription factors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8713.
Full textSieber, Martin Sieber Martin. "DNA binding reaction of basic-helix-loop-helix proteins /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13578.
Full textBloor, A. J. C. "Proteins for the basic helix-loop-helix transcription factor SCL." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596727.
Full textImabayashi, Takeshi. "Expression of basic helix-loop-helix proteins in the glomeruli." Kyoto University, 2001. http://hdl.handle.net/2433/150563.
Full textMa, Philip Chun-Ming. "Structural studies on the basic-helix-loop-helix region from MyoD." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/28070.
Full textSato, Tetsu. "The Basic Helix-Loop-Helix Gene hesr2 promotes gliogenesis in mouse retina." Kyoto University, 2004. http://hdl.handle.net/2433/148268.
Full textHayward, Penelope Caroline. "The basic helix-loop-helix protein SCL and its role in haematopoietic development." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603895.
Full textHufnagel, Robert B. "The Role of Basic Helix-Loop-Helix Transcription Factors in Early Retinal Neurogenesis." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282932913.
Full textBloor, Adrian John Clifton. "Identification of novel partner proteins for the basic helix-loop-helix transcription factor SCL." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619716.
Full textJhas, Sumitpal. "Regulation of cortical neuron and astrocyte differentiation by the basic helix loop helix protein Hes6." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18671.
Full textDurant le développement du cortex cérébral mammifère, des cellules souches neuronales situées dans la zone ventriculaire se différencient en neurones, astrocites, et oligodendrocites. Durant ce développement la neurogenèse prend place en premier, suivi par la différenciation des astrocites et celle des oligodendrocites. Les mécanismes régulateurs de la différenciation sont en parti sous le control des facteurs de transcriptions « basic-helix-loop-helix » (bHLH) appartenant au groupe « Hairy/Enhancer of split » (Hes). Plusieures protéines Hes sont activées par la signalisation de Notch. Ces protéines, tel Hes1 et Hes5, sont des inhibiteurs de transcription durant la neurogenèse corticale et promeuvent la différentiation des astrocites. Par contre Hes6, insensible aux signaux de Notch, promeut la neurogenèse. Les objectifs de cette étude consistent à: 1) mieux comprendre les mécanismes moléculaires de l'activité de Hes6 ; 2) étudier le rôle potentiel de Hes6 dans la différenciation des cellules glies. Nous avons analysé l'habileté de différents mutants de Hes6 à promouvoir la neurogenèse en employant un système de culture cellulaire primaire de cellules souches neuronales. De plus, ces différentes formes de Hes6 ont été testées pour leur effet sur l'inhibition de la différenciation des astrocites. Nous démontrons que Hes6 inhibe l'astrogenèse et promeut la différenciation neuronale. Ces deux activités requèrent différentes domaines structurelles, laissant présager différents mécanismes moléculaires.
Narumi, Osamu. "OUT, a Novel Basic Helix-Loop-Helix Transcription Factor with an Id-like Inhibitory Activity." Kyoto University, 2000. http://hdl.handle.net/2433/180866.
Full textMacAlister, Cora Ann. "The role of the basic helix loop helix transcription factor speechless in the initiation of the stomatal lineage /." May be available electronically:, 2009. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textBergstrom, Donald Alan. "Orchestration of skeletal myogenesis by the myogenic bHLH family of transcription factors /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6358.
Full textSakamoto, Masami. "The Basic Helix-Loop-Helix Genes Hesr1/Hey1 and Hesr2/Hey2 Regulate Maintenance of Neural Precursor Cells in the Brain." Kyoto University, 2004. http://hdl.handle.net/2433/147494.
Full textQian, Yingjuan. "The role of DEC1 in P53-dependent cellular senescence." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/qian.pdf.
Full textOtsuka, Toshiyuki. "Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons." Kyoto University, 1998. http://hdl.handle.net/2433/182245.
Full textSimionato, Elena. "Evolution et diversification des protéines à basic Helix-Loop-Helix chez les métazoaires : apports pour la compréhension de l'évolution du système nerveux et de la neurogenèse." Paris 11, 2008. http://www.theses.fr/2008PA112213.
Full textIn order to understand the nervous system evolution, during my thesis I have studied some basic Helix-Loop-Helix (bHLH) proteins involved in neural development and their conservation or divergence during animal evolution. First, an extensive search for bHLH genes has been conducted in species representative of the main metazoan lineages, including three non-bilaterian species, two cnidarians and a sponge Amphimedon queenslandica. The phylogenetic analyses allowed us to propose an evolutionary scenario for the diversification of this superfamily in metazoans. Then, I have studied a sponge bHLH gene, AmqbHLH1, which is homolog to the bilaterian proneural genes, atonal and neurogenin. The expression of AmqbHLH1, as well as of homologs of Notch and Delta,in dicates that these genes may be involved in the formation of sensory cells in the sponge. I have also demonstrated that AmqbHLH1 has a proneural activity that is a combination of the properties of the neurogenin and atonal genes. We have inferred that the bilaterian neurogenic circuit, comprising proneural bHLH genes coupled with Notch/Delta signalling, was functional in the very first metazoans and was used to generate an ancient sensory cell type. Finally, to decipher which aspects of the function of bHLH genes are ancestral to bilaterians and which are derived characters specific of some lineages, I have studied the expression of several neural bHLH genes in an annelid, Platynereis dumerilii. All the identified genes are expressed during the formation of the Platynereis nervous system and some of these genes may have proneural or neural specification functions in a similar fashion to that observed in vertebrates
Schmidt, Johanna Maria [Verfasser], and Magdalena [Akademischer Betreuer] Götz. "Temporal and cell-specific effects of the basic Helix-Loop-Helix Transcription factor Twist1 during breast cancer progression / Johanna Maria Schmidt ; Betreuer: Magdalena Götz." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1160876428/34.
Full textOktay, Yavuz. "Defining a novel role for hypoxia inducible factor-2 alpha (HIF-2a)/EPAS1 : maintenance of mitochondrial and redox homeostasis." Access to abstract only; dissertation is embargoed until after 12/20/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=134.
Full textSteen, Håkan. "Novel Interactors of X-linked Inhibitor of Apoptosis Protein : Expression and Effects on Tumor Cell Death." Doctoral thesis, Uppsala University, Neurobiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8742.
Full textProgrammed cell death, or apoptosis, has during the last decade received a lot of attention due to its involvement in a large number of pathological conditions. Since death is always irreversible, it is important for cells to fully control the initiation and execution of this process. One of many apoptosis-regulatory proteins is XIAP, which blocks the action of caspases, a family of proteases that are important during apoptosis. However, apoptosis inhibitors have to be tightly controlled since too little cell death can lead to the development of tumors and other diseases. This thesis is the result of an aspiration to fully understand the function and regulation of XIAP.
By using the yeast-2-hybrid system, we identified two novel binding partners of XIAP. The first, GPS2, was found to bind XIAP and inhibit its ability to block caspase-activity. In addition, GPS2 induced caspase-mediated cell death in two different tumour cell lines and XIAP inhibited this effect.
The second binding partner, Nulp1, preferentially bound XIAP in the presence of the apoptosis-inducer staurosporine. Nulp1 induced or sensitized cell lines to cell death when overexpressed, but this was not blocked by caspase-inhibitors or XIAP, suggesting a different reason for binding than apoptosis regulation. With the aim to understand the Nulp1-XIAP interaction, we continued to study Nulp1 in vivo and in vitro. We studied three different splice variants of Nulp1 and found that they were regulated by poly-ubiquitination and nuclear shuttling. Also, Nulp1 was expressed in embryonic mice, especially in the cortical plate, hippocampal neurons and cerebellar granular neurons. Expression of Nulp1 decreased with age but was still present in cerebellar deep nuclei and Purkinje cells of adult mice.
To summarize, we have identified GPS2 as an apoptosis-inducing factor and an inhibitor of XIAP in vitro, and Nulp1 as a XIAP-interacting protein during staurosporine-induced apoptosis.
Chen, Tingting [Verfasser], Brigitte [Akademischer Betreuer] Poppenberger-Sieberer, Ralph [Gutachter] Hückelhoven, and Brigitte [Gutachter] Poppenberger-Sieberer. "Characterization of factors that may modulate function of the basic helix-loop-helix protein CESTA / Tingting Chen ; Gutachter: Ralph Hückelhoven, Brigitte Poppenberger-Sieberer ; Betreuer: Brigitte Poppenberger-Sieberer." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1149824166/34.
Full textRavanpay, Ali Cyrus. "Insights into the molecular interactions of the neurogenic basic helix-loop-helix transcription factor, neuroD2, and the mechanism of regulation of a key target, RE-1 silencing transcription factor /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10628.
Full textChao, Christina Seng. "The roles of Nkx2.2 in determination of mouse islet cell fates /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
Find full textTypescript. Includes bibliographical references (leaves 144-158). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
Wikström, Ingela. "Molecular genetics of B- and T-lymphocyte development /." Umeå : Department of Medical Biosciences, Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-802.
Full textRuan, Xuan 1974. "Differential circadian regulation of Bmal1 transcription by orphan nuclear receptors." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112358.
Full textGlasgow, Stacey Marie. "The role of PTF1A in spinal cord development." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=155.
Full textJohansson, Térèse A. "Pancreatic Endocrine Tumourigenesis : Genes of potential importance /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9294.
Full textYu, Elizabeth A. "Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/544.
Full textOtto, Aline Pedrosa. "Análise molecular do gene HES1 em pacientes portadores de hipopituitarismo congênito." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-27082014-112356/.
Full textStudies of transgenic animal models have allowed for the discovery of genes involved in human pituitary embryogenesis and the genetic etiology of hypopituitarism. However, the genetic causes of most cases of congenital hypopituitarism, especially those associated with an ectopic posterior pituitary, remain poorly defined. Mutations in the gene PROP1 are the most common genetic causes of hypopituitarism described to date, and are always associated with an ectopic posterior pituitary. Studies to elucidate the molecular mechanisms of Prop1 mutations in mice have demonstrated the involvement of the Notch signaling pathway, including its downstream target Hes1. The HES1 gene encodes a transcription factor that participates in early stages of pituitary development and is involved in posterior pituitary morphogenesis. Hes1 knockout mice exhibit a hypoplastic anterior pituitary and absence of a posterior pituitary. Conversely, constitutive expression of Hes1 is associated with hypopituitarism. Since an ectopic posterior pituitary is commonly found in congenital hypopituitarism and the HES1 gene may be related to its pathophysiology, the coding region of gene HES1 was screened in 192 patients with congenital hypopituitarism. A heterozygous allelic variant c.578G >A (p.G193D) was identified in a patient with congenital hypopituitarism associated with an ectopic posterior pituitary. Assessment by MutationTaster, a bioinformatic tool for in silico prediction of functional effect of missense variants, suggests that substitution of glycine (a highly conserved amino acid in this position among mammals) for aspartic acid is deleterious. In the genetic study of family members, we identified four apparently normal siblings with the same variant, two of which have discrete changes in their pituitary MRI. In conclusion, we described a new allelic variant in the gene HES1, absent in large databases and healthy Brazilian controls, but present in the unaffected siblings. In vitro functional studies are needed to clarify the biological effect of this variant. A complex pattern of inheritance with incomplete penetrance is possible in this case, as it has already been described in other genes associated with hypopituitarism. In an attempt to elucidate the genetic cause of hypopituitarism in the family described, DNA samples of this patient and his family were submitted to exome sequencing, but results are inconclusive at this time
Varshney, Gaurav. "Identification of downstream targets of ALK signaling in Drosophila melanogaster /." Doctoral thesis, Umeå : Umeå universitet, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1894.
Full textJohnston, Brian T. "Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/639.
Full textKumar, Meenakshi Swaminathan. "Regulation of smooth muscle differentiation by E-boxes, basic helix-loop-helix (bHLH) proteins, and bHLH-interacting factors /." 2003. http://wwwlib.umi.com/dissertations/fullcit/3077320.
Full textBertulat, Bianca. "Identifizierung und Charakterisierug von basic Helix-Loop-Helix (bHLH)- Transkriptionsfaktoren im Zusammenhang mit dem interstitiellen Stammzell-System des Süßwasserpolypen Hydra." Phd thesis, 2008. https://tuprints.ulb.tu-darmstadt.de/980/1/bertulat_2008_Teil1.pdf.
Full textBertulat, Bianca [Verfasser]. "Identifizierung und Charakterisierug von basic Helix-Loop-Helix (bHLH)-Transkriptionsfaktoren im Zusammenhang mit dem interstitiellen Stammzell-System des Süßwasserpolypen Hydra / von Bianca Bertulat." 2008. http://d-nb.info/988983281/34.
Full textBersten, David Christopher. "Regulation of expression and activity of the bHLH-PAS transcription factor NPAS4." Thesis, 2014. http://hdl.handle.net/2440/96833.
Full textThesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2014
Whelan, Fiona. "The aryl hydrocarbon receptor: structural analysis and activation mechanisms." Thesis, 2010. http://hdl.handle.net/2440/95877.
Full textThesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Sciences, Discipline of Biochemistry, 2009
Espira, Leon Masunde. "The basic helix-loop-helix transcription factor scleraxis regulates cardiac fibroblast collagen gene expression." 2009. http://hdl.handle.net/1993/21353.
Full textHuang, Kai-min, and 黃凱民. "Myogenic basic helix-loop-helix transcription factors regulate PGC-1α during terminal myogenic differentiation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/22729909948641516355.
Full text國立中央大學
生命科學研究所
95
Skeletal muscle are generally classified as two types – type I (slow - twitch) and type II (fast - twitch). The former is rich in mitchondria and thus provides constant ATP through oxidative metabolism. The latter depends on the glycolytic metabolism as the energy source. PGC-1α is a transcriptional coactivator mainly expressed in the slow-twitch fibers. Previous studies indicated that over-expression of PGC-1α promotes the conversion from fast-twitch fibers to slow-twitch fibers. According to previous observations, we know that the E2-box on the PGC-1α promoter is essential for MyoD-mediated transactivation. In this study, we found that Stra13, a putative E1-box binding transcriptional repressor, repressed the MyoD mediated PGC-1α promoter activation. The interaction between MyoD and Stra13 was almost undetectable by GST-Pull down assay and EMSA. In addition, over-expression of P/CAF, but not CBP, can rescue the Stra13-mediated repression. These data suggest that Stra13 represses MyoD-mediated PGC-1 activation by sequestering P/CAF from MyoD.
Brzózka, Magdalena Marta. "Untersuchungen zur Funktion des basischen Helix-Loop-Helix (bHLH)-Transkriptionsfaktors ME2 bei Lern- und Gedächtnisprozessen in der Maus." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-AD69-F.
Full textBrzózka, Magdalena Marta [Verfasser]. "Untersuchungen zur Funktion des basischen Helix-Loop-Helix (bHLH)-Transkriptionsfaktors ME2 bei Lern- und Gedächtnisprozessen in der Maus / vorgelegt von Magdalena Marta Brzózka." 2008. http://d-nb.info/996829318/34.
Full textHolder, Jimmy Lloyd Jr. "The bHLH/PAS transcription factor SIM1 is a novel obesity gene." 2005. http://edissertations.library.swmed.edu/pdf/HolderJ050305/HolderJimmy.pdf.
Full text