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Daniels, Robert McLane. "Basement." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1439288357.
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Tkac, Samantha Constance. "Basement Heart." Digital Commons @ Butler University, 2019. https://digitalcommons.butler.edu/grtheses/513.
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Basement Heart is a collection of short stories with a goal of documenting the manifestations of rage and how it evolves throughout a woman’s life. In these stories, femininity is explored through the aesthetics of the grotesque. Female protagonists seek to inhabit new definitions of female sexuality that combat tired expectations made by society’s misogynistic and objectifying culture. Often, their feelings of unprovoked grief manifest themselves as pursuits of the flesh, which becomes the underlying heartbeat of each story; themes revolve around sex and obsession and explore what happens when sexual fantasies are realized and lived out in the real world. When characters inhabit their bodies in ways that American culture tells women not to, they become viscerally self-aware and better their understanding of what they want. And doing what they want is all these women care about. The characters in Basement Heart are angry, restless, and at times driven mad by their own lust for control.
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Cleutjens, Jacobus Peter Marie. "Basement membrane heterogeneity." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5472.
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Diaz, Suarez Carlos Fernando. "Basement failure diagnosis expert system /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu148784154827184.
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Wootton, Andrew. "The glomerular basement membrane and nephritis /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phw918.pdf.
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Kimber, Roger Neil. "Carboniferous basement rocks of northern Britain." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6787/.
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The study of Carboniferous basement rocks of northern Britain has concentrated on the dominantly clastic rock succession which unconformably overlies the Lower Palaeozoic basement and occurs beneath the lowermost Carboniferous limestones in areas surrounding the Vale of Eden. The clastic rocks exposed at Shap, the Mell Fells (Ullswater), Sedbergh and Cross Fell, mainly reflect fluvial deposition over an Upper Palaeozoic landscape which locally had considerable topographic relief. Within each clastic rock succession, which throughout the region varies in thickness from ca 4m to over 250m, overall largescale fining upward sequences document the evolution from gravel-dominated braided fluvial to sand-dominated braided fluvial deposits. This evolution is shown to be representative of the downstream transition from localised alluvial fans into a more extensive fluvial braidplain system, the latter also containing marked proximal to distal variations. Palaeocurrents are consistently toward the north and north-east throughout the region, demonstrating the existence of a broad northerly palaeoslope during clastic deposition. Proximal to distal relationships and clast provenance data for each area are used to predict fades variations across the Vale of Eden region and to reconstruct the Palaeogeography. Areas of high ground are shown to be underlain by deep-seated Caledonide granite plutons, evolution of the fluvial braidplain demonstrating that with time denudation of high ground developed fining upward sequences by the superposition of progressively finer grained sediment on coarse. The development of the braidplain system is related to post-intrusive uplift of the granites underlying the highest ground with deposition mainly taking place prior to marine limestones associated with the basal Carboniferous marine transgression. A comparison with the Upper Old Red Sandstone clastic succession of the Northumberland Border Basin is assessed.
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Elena, García Pilar. "Basement-cored uplift deformation in the northern Sierras Pampeanas: Three-dimensional uplift structure, basement deformation, and regional analysis." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/280775.
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The structure of basement-cored uplift mountains is fundamentally controlled by the geometry of the basement and the basement unconformity. In the Sierra de Hualfin, an uplift located in the Sierras Pampeanas of NW Argentina, the well-exposed basement unconformity displays along-strike structural variations. The Sierra de Hualfin is composed of a core of Ordovician granitoid overlain by and thrust over Tertiary sedimentary rocks. The range is uplifted by an east-directed thrust fault, creating a steep range-front on the east and a gently dipping backlimb on the west. In the central region, however, basement and cover rocks in the backlimb are folded. Cross sections across the uplift and a three-dimensional computer model show that the variations along strike are due to differences in the geometry of the underlying fault or faults that deform the basement unconformity. Analysis of the folded basement unconformity on the west side of Sierra de Hualfin shows that brittle processes of faulting, cataclasis and fracture foliation help the basement attain a folded form. Pervasive and continuous joint fractures, and an unconformity-parallel fracture foliation at the surface, set up a condition for "flow" of granitic materials. Additionally, in order for basement to fold, the tip of the underlying fault must be located within the basement before it begins propagating towards the surface. Using the knowledge gained from the detailed structural studies, two regional cross sections were constructed in the region of Sierra de Hualfin, showing spatial and geometric relations between the adjacent uplifts, and the thrust systems of the eastern Puna Plateau. The cross sections show detachment levels at 16 km and ∼27 km for uplifts in the northern Sierras Pampeanas. Thrust faults of the northern Sierras Pampeanas, and of the eastern edge of the Puna can be interpreted as part of the same east-directed thrust system, with intervening west-directed backthrust development. The combination of the modeling of Sierra de Hualfin and the regional cross sections with detachments at 16 to 27 km depth suggests that basement-cored uplifts can be formed by gently-dipping faults detaching in the middle crust and near the base of the crust.
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Devaka, K. Weerakoon Cheung H. Tak. "Interaction of macrophages with the basement membrane." Normal, Ill. Illinois State University, 1995. http://wwwlib.umi.com/cr/ilstu/fullcit?p9603526.
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Thesis (Ph. D.)--Illinois State University, 1995.Title from title page screen, viewed May 8, 2006. Dissertation Committee: Hou Tak Cheung (chair), David W. Borst, Herman E. Brockman, Alan J. Katz, Anthony J. Otsuka. Includes bibliographical references (leaves 98-110) and abstract. Also available in print.
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Pless, Jennifer Claire. "Characterising fractured basement using the Lewisian Gneiss Complex, NW Scotland : implications for fracture systems in the Clair Field basement." Thesis, Durham University, 2012. http://etheses.dur.ac.uk/3489/.
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1-, 2- and 3-dimensional fracture network characteristics of the mainland Lewisian Gneiss Complex (LGC) have been used assess if the LGC is a suitable onshore analogue for the fracture networks within the offshore Clair basement. Faults that cut the Clair basement rocks are becoming increasingly recognised as important structural conduits that connect (oil & gas bearing) sedimentary packages across the main basement structure. The basement of the Clair field is poorly understood, with limited seismic and well datasets; so using an onshore fracture analogue, of the mainland LGC, will hopefully improve the understanding of the Clair basement fracture systems. To determine the suitability of the mainland LGC as an analogue for the Clair basement four main research questions are asked in this thesis: What is the offshore Clair basement? What are the geological characteristics and attributes of the fracture networks in the mainland LGC? What are the dominant controls on these fracture network characteristics? How can the mainland Lewisian be used as an analogue for the Clair basement? Onshore datasets (outcrop, terrestrial laser scans & NEXTMap® DEM) exhibit prominent NE-SW and/or NW-SE fault and fracture trends. The Clair basement seismic dataset exhibits comparable NE-SW & NW-SE trending faults, but the basement core samples exhibit a strongly aligned NNE-SSW fracture trend that is not so clearly represented in the onshore datasets. Fracture spacing distributions from the mainland LGC have strong power-law relationships over at least three orders of magnitude. Power-law relationships are also present from Clair basement datasets but the lack of large datasets means that these relationships are considered fairly weak. Qualitative and Quantitative onshore and offshore analyses suggest that the mainland LGC is a suitable analogue for the Clair basement to some degree, but that their relationship is not a simple one. The results presented in this thesis do not provide a unique solution for the Clair basement fracture networks. Instead the onshore data provide model types that can be used in sensitivity models to ultimately assess which onshore dataset provides the best geological and statistical analogue for the Clair basement.
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Meißner, Birgit. "Tektonometamorphe Entwicklung von Scherzonen im präkambrischen Basement Südindiens." Diss., lmu, 2001. http://nbn-resolving.de/urn:nbn:de:bvb:19-4299.
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Amirzehni, Elnaz. "Seismic assessment of basement walls in British Columbia." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57846.
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The current state of practice for seismic design of basement walls in Vancouver is based on the Mononobe-Okabe (M-O) method using a Peak Ground Acceleration (PGA) mandated by the National Building Code of Canada (NBCC, 2010). Because there is a little evidence of any significant damage to basement walls during major earthquakes, the Structural Engineers Association of British Columbia (SEABC) became concerned about designing the walls under the code-mandated PGA and set up a task force to review the current procedure for seismic design of basement walls in British Columbia (BC). The University of British Columbia (UBC) was asked to carry out this investigation. This thesis aims to provide solid base for designing the basement walls using an appropriate fraction of the code-mandated PGA in the M-O analyses. To this end, a series of dynamic nonlinear soil--structure interaction analyses are conducted to examine the seismic resistance of typical basement walls designed according to current practice in BC, for different fractions of the code mandated PGA (100% to 50%). The seismic responses of the walls are evaluated by subjecting them to ensembles of ground motions comprised of shallow crustal, deep subcrustal, interface earthquakes from a Cascadia subduction events and near-fault earthquake motions. Input motions are matched to the intensity of the seismic hazard using both spectral and linear scaling techniques. Representative 4-level and 6-level basement walls are analyzed. The nonlinear hysteretic response of the foundation soil is characterized in order to obtain realistic estimates of an interaction between the basement wall and the surrounding soil. In addition, the effects of the local site conditions in terms of geometrical and geological structure of soil deposits underlying the basement structure on the seismic performance of the basement walls are evaluated. The analyses show that current engineering practice for designing basement walls based on the M-O method and using 100% PGA is too conservative. The analyses suggest that a wall designed using 50% to 60% PGA results in an acceptable performance in terms of drift ratio.Applied Science, Faculty of
Civil Engineering, Department of
Graduate
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Visser, Robbert. "Basement membrane antigens in preneoplastic and neoplastic conditions." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5867.
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Wong, Michael Y. C. "Biochemical characterization of Goodpastures Antigen in Basement membranes." Thesis, King's College London (University of London), 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508355.
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Hay, Stephen John. "Permeability - past and present - in continental crustal basement." Thesis, University of Glasgow, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278258.
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Esperancinha, Sérgio Carreiras. "SEAL basin fractured basement: challenging the exploration paradigm." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/9756.
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Mestrado em Geomateriais e Recursos GeológicosA bacia onshore de Sergipe-Alagoas, onde a GALP Energia detém dois blocos exploratórios, possui um exemplo provado de um Reservatório Naturalmente Fracturado no soco cristalino (Embasamento na terminologia brasileira utilizada nesta tese). Nestes blocos, sete poços verticais foram completados com sucesso, e em todos, o Embasamento Fracturado (cujas características foram provadas através do uso da ferramenta de imagem – Formation Micro Imager ou FMI – e de testes a poço aberto – Drill Stem Tests ou DST) foi o intervalo que apresentou os melhores resultados. Nesta tese, foi feita uma análise extensiva da estratégia exploratória, desde a aquisição sísmica aos resultados e procedimentos dos poços, e uma Estratégia de Exploração alternativa foi apresentada como conclusão. Esta análise integrou dados provenientes dos sete poços realizados com dados do Projecto de Modelação do Embasamento Fracturado (uma parceria entre GALP e uma equipa composta por elementos da Universidade de Aveiro, Universidade Nova de Lisboa, Universidade do Algarve e Instituto Superior Técnico). Neste projecto as equipas utilizaram dados sísmicos (planos de falhas interpretados manualmente) e dados de FMI (a partir dos quais as principais orientações de fracturação foram extraídas) para simular um elemento geométrico correspondente ao Embasamento. A essa rede foram aplicados princípios de geomecânica juntamente com modelação DFN (Density Fracture Network), permitindo simular a permeabilidade de fractura para cada uma das famílias extraídas dos dados de FMI. Estes dados permitiram ao autor calcular o volume de hidrocarbonetos presentes e simular um poço direccional para ser que deverá ser efectuado em alternativa os poços verticais perfurados até agora.
The Sergipe-Alagoas, onshore Basin, where GALP Energia holds two exploration blocks, has an example of a proven Naturally Fractured Basement Reservoir. In these blocks seven vertical wells were successfully drilled, and in all seven, fractured Basement (which was proven by the use of Formation Micro Imaging – FMI – tool and the results of the Drill Stem Tests - DST) presented the best results. In this thesis an extensive analysis of the exploration strategy, ranging from seismic acquisition to drilling /testing results and procedures, was made, and an alternative Exploration Workflow was presented as a conclusion. This analysis integrated data from the study of the drilling and testing procedures, with data from the Fractured Basement Project (a joint project with Universidade de Aveiro, Universidade Nova de Lisboa, Universidade do Algarve and Instituto Superior Técnico). In this project the team used seismic data (mainly interpreted fault surfaces) and FMI data (from which fracture families were extracted), and by applying geomechanical principles together with Density Fracture Network (DFN) modelling created permeability maps per fracture family. This allowed the author to calculate the Hydrocarbons Initially in Place (HIIP) and simulate a directional well to be drilled as an alternative to the vertical wells drilled so far.
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Melian, Nadia. "Basement membrane composition of Dag1 null chimaeric mice kidneys." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33809.
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The growth of an organism involves the proliferation and migration of cells within an extracellular matrix. As a cell surface receptor, the Dag1 gene product dystroglycan links the intracellular cytoskeleton to the extracellular basement membrane in many cells. Thought to act as a structural protein dystroglycan may also participate in signal transduction. This study aims to better understand the role of dystroglycan during kidney morphogenesis. I hypothesised that a lack of dystroglycan in the precursor cells of the kidney could lead to altered kidney growth. Chimaeric mice deficient in dystroglycan were generated to test this hypothesis. A total of 38 chimaeras had genetic contribution and histological analysis performed on their kidneys. Of the chimaeras analysed, only four demonstrated altered kidney morphology. Further histological, immunohistochemical and biochemical studies established whether a link existed between this morphology and a deficiency in dystroglycan. Normal laminar architecture and nephrotic structures of the kidneys suggest that normal kidney organogenesis occurred in the absence of dystroglycan. The pattern and expression level of basement membrane components suggests that normal basement membrane formation also occured in the absence of dystroglycan. Biochemical analysis revealed that although dystroglycan protein levels correlate with the genetic contribution of the chimaeric kidney, it does not correlate with the altered morphology. Ureter blockage causing hydronephrosis can explain the morphology observed. A deficiency of dystroglycan in the ureter may in turn have caused this blockage. These findings suggest that dystroglycan is not necessary for kidney organogenesis, since kidney development occurred normally in all 38 chimaeric animals irrespective of genetic contribution.
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Burton, Victoria Jane. "Neutrophil migration through endothelial cells and their basement membrane." Thesis, University of Birmingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532273.
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Forster, Simon J. "Basement membrane proteins and the spread of rectal cancer." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35223.
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Antisera to the basement membrane proteins laminin, fibronectin and type IV collagen were prepared, characterized and rendered monospecific by appropriate treatments. Methods were developed to allow the use of these antisera for inmunohistochemical staining of sections of tissue which had been preserved by several methods. In particular, the use of protease digestion {"unmasking") to allow staining of formalin-fixed, paraffin-embedded material was studied. The presence and intensity of staining was found to be highly dependent on the protease and the conditions of digestion, the type of basement membrane, and whether the tissue was normal or neoplastic. The distributions of the three proteins were studied in normal colorectal mucosa and in colorectal adenocarcinoma. A detailed retrospective study was made of the distribution of laminin in 158 cases of rectal carcinoma. Tumours fell into two groups: those which showed linear basement membrane-like laminin staining (laminin positive) and those which did not (laminin negative). Patients with laminin positive tumours had a reduced incidence of distant metastasis and an increased 5 yr survival rate; these correlations were statistically highly significant. Carparison by multivariate analysis with other widely used prognostic markers indicated that laminin status has considerable potential for use as a prognostic marker in the management of such patients. The antisera were also used in a study of the cellular origin and biosynthesis of basement membrane proteins in three systems. In a basement membrane-producing murine tumour, intracellular staining was seen, but it was found that different methods of tissue preparation and unmasking drastically affected the apparent distributions of the three antigens. In the developing rat intestine, no evidence was seen of basement membrane synthesis by the intestinal epithelial cells. However in isolated rat intestinal epithelial cells, some evidence was found for synthesis of laminin and fibronectin, but not type IV collagen.
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Huang, Leslie. "Pre-rift evolution of Malawian high-grade basement rocks." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25307.
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There is some controversy in terms of the basement geology of Malawi which ultimately stems from the overall lack of metamorphic studies conducted in the area. The geological complexity of Malawi comes from that fact that it sits at the intersection of three major orogenic belts: The Palaeoproterozoic Ubendian Belt, Mesoproterozoic Kibaran/Irumide Belt, and Pan African Mozambique Belt. Its complexity makes it difficult to unravel, especially in terms of identifying features of older orogenic events which have already experienced multiple metamorphic overprinting from subsequent events. This thesis provides a more detailed pre-rift evolution of the Malawian basement rocks by reporting ages and P-T conditions from four localities surrounding Lake Malawi, namely Chilumba, Mlowe, Maganga, and Mangochi. Results reveal that at 1985-1974 Ma, garnet-cordierite granulites were equilibrated under conditions of 760°C at 4.5-5 kbar possibly as a result of subduction-related magmatism. Subsequently, at 1100 Ma, charnockites were emplaced and metamorphosed under peak conditions of 770-780°C at 4.3-6 kbar due to Kibaran-age magmatic underplating. Remnants of the Irumide/Kibaran Orogeny is relatively scarce throughout Malawi and although the Mangochi charnockites were emplaced during Kibaran-age tectonism, it also experienced at least two different metamorphic events thereafter. The first occurred either during early stages of the East African orogen or Rodinia break-up at 900-800 Ma while the second occurred during the late stages of the East African orogen at 650-600 Ma. Possible remnants of the Kuunga Orogeny are recorded in Chilumba and Maganga as an amphibolite facies metamorphic event which took place around 570 Ma under peak conditions of roughly 660-670°C at 6-8 kbar. Findings of this study have not only provided a more detailed metamorphic history of Malawi but also paved way for future studies in the area to further explore why similar rocks found in such close proximity to each other preserve vastly different tectonic environments.
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Oliver, David Owen. "The development of structural patterns above reactivated basement faults." Thesis, Boston Spa, U.K. : British Library Document Supply Centre, 1987. http://ethos.bl.uk/OrderDetails.do?did=1&uin=uk.bl.ethos.263240.
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Ameen, Mohammed Sulaiman. "Folding of layered cover due to dip-slip basement faulting." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/7611.
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Kerr, Ian David Victor. "Basement / cover structural relationships in the north Antrim area, Ireland." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317088.
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Zhang, Xu. "Basal lamina genes affected in leiomyomatosis and congenital muscular dystrophy : structure and mutation analyses of the collagen COL4A6 and laminin LAMA2 genes." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2780-4.
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Li, Yi-Yang Cheung H. Tak. "Basement membrane and its components on lymphocyte adhesion, migration, and proliferation." Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9234466.
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Thesis (Ph. D.)--Illinois State University, 1992.Title from title page screen, viewed January 27, 2006. Dissertation Committee: H. Tak Cheung (chair), Anthony Otsuka, Alan Katz, Brian Wilkinson, David Weber. Includes bibliographical references (leaves 108-120) and abstract. Also available in print.
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Steck, Christian D. "Correlation of gravity anomalies with Precambrian crystalline basement, Bellefontaine Outlier, Ohio /." Connect to resource, 1997. http://hdl.handle.net/1811/24797.
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Shima, Thomas Brent. "Isolation, structural and immunohistochemical characterization of basement membrane heparan sulfate proteoglycan." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61197.
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Heparan sulfate proteoglycan (HSPG) was isolated from the mouse Engelbreth-Holm-Swarm (EHS) tumor. Polyclonal antibodies against the isolated HSPG were raised by two separate techniques, both producing highly reactive antisera. The antisera were found to be reactive against epithelial basement membrane of the mouse foot pad, glomerular basement membrane of the kidney and the EHS tumor matrix using the techniques of light microscopic immunoperoxidase on frozen sections and electron microscopic immunogold labelling on ultrathin Lowicryl K4M sections. At high magnification of the EHS tumor matrix, the gold particles were found over 5 nm wide sets of parallel lines, referred to as "double tracks" (Inoue et al., 1989). When HSPG was incubated in 50 mM Tris buffer, pH 7.4, at 35$ sp circ$C for either 5 min or 1 hr, a precipitate resulted which was made up of 5-6 nm wide sets of parallel lines, similar to double track structures. Together these studies demonstrate that HSPG of the EHS tumor matrix is made up of double track structures, and that in vitro incubation of HSPG produces double track structures in as short a time as 5 min.
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Tein, Mark S. C. "Studies on basement membrane permeation : models of pathogenic mechanims of glomerulonephritis." Thesis, University of Oxford, 1994. http://ora.ox.ac.uk/objects/uuid:22440bfc-e712-4f7c-a11d-2eed9b07bcb6.
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The effects of the biological cross-linker transglutaminase, the neutrophil oxidant hydrogen peroxide, and neutrophil proteinases on glomerular basement membrane permeability have been examined using an in vitro model of glomerular ultrafiltration. The main focus of the study lies in determining whether any of the test agents were able to render glomerular basement membrane more permeable to protein. Guinea pig liver transglutaminase was used as a model enzyme to test for the effect of biological cross-linkers on glomerular basement membrane permeability. It cross-linked glomerular basement membrane proteins, caused membrane contraction, and rendered glomerular basement membrane less permeable both to water and the low molecular weight protein marker myoglobin but had no effect on the membrane permeability to the high molecular weight marker protein bovine serum albumin or serum protein. The pathophysiological relevance of the effect is discussed. Hydrogen peroxide increased glomerular basement membrane permeability to water and proteins but the effect depended on hydrogen peroxide concentration and incubation time. The minimum concentration needed to render glomerular basement membrane more permeable to bovine serum albumin and serum protein was 1 M and the minimum incubation time needed was 6 hrs. A respiratory burst analysis of activated neutrophils showed that the average concentration of hydrogen peroxide that could be generated by the neutrophils was less than 50 mM and the time taken for extracellular hydrogen peroxide concentration to fall off to zero was less than 1 hr. Therefore, neutrophils seemed unable to generate and sustain a sufficiently high hydrogen peroxide concentration to render glomerular basement membrane more permeable to protein in vivo. Proteinases extracted from pig neutrophil granules were used to assess their effect on glomerular basement membrane permeability. The extract showed activity against glomerular basement membrane and the activity was primarily attributed to the serine proteinases elastase and cathepsin G, judged from substrate and inhibitor analyses. The proteinase extract also contain latent metalloproteinases, activatable by the organomercurial 4-aminophenyl mercuric acetate and calcium ions. Once activated, they also showed activity against glomerular basement membrane. The extract rendered glomerular basement membrane more permeable to water, myoglobin, bovine serum albumin, and serum protein. The increase in membrane permeability to water and proteins was due to membrane thinning and an increase in the intrinsic porosity of the membrane. When the serine and metalloproteinases were allowed to act in concert, they synergistically degraded glomerular basement membrane and increased the membrane permeability to serum protein and water. The study provides the first direct evidence that pathophysiological amounts of serine and metalloproteinases are able to render glomerular basement membrane more permeable to protein and suggests they may be capable of promoting proteinuria in neutrophil-dependent forms of immune glomerulonephritis.
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Snällfot, David. "Decision Opportunity & Choice Architecture : On the risk of basement floods." Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-19088.
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In the paper I propose a decision opportunity for the problem of basement flooding caused by heavy precipitation: property owners can mitigate this risk before it materializes. Implementing the decision opportunity requires an active choice. Social science findings suggest comprehensive and pervasive information processing deficiencies together with contextual influences strongly affect decision behavior. Presenting the decision opportunity in a way that limits negative interference from these behavioral problems is therefore a key theme of the paper. I adopt the PrOACT approach to analyze and resolve these distinct problems. This involves exploring relevant objectives for property owners and for the presentation of the decision opportunity. I consider several technical as well as behavioral alternatives. Backwater valves represent the main group of the former and choice architectural tool sets the latter. Backwater valves block sewage backflow while choice architecture concerns how to present a choice given behavioral problems. By considering the consequences of these alternatives on the relevant objectives the process of eliminating dominated alternatives is pursued, followed by making tradeoffs which enable the identification of suggested choices. Subsequently, I propose that the mechanical backwater valve is preferable for implementing the decision opportunity. This alternative scored well on providing protection, being relatively cheap and involved few additional inconveniences relative to doing nothing about the risk. For presenting the decision opportunity the paper suggests the choice architectural tool set of customization and technology. This alternative scored well on promoting an active choice, promoting welfare increasing choices and providing guidance to property owners. However, its shortcoming is found in its limited capacity to reach all relevant property owners. The paper identifies a need for experimental evidence on the effects of these suggested measures. The starting point for such experimental explorations is further proposed to originate from the paper’s suggested choices.
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Hedin, Baastrup Hugo. "Structural Reconnaissance Mapping of the Nasa Basement Window, Southern Norrbotten Caledonides." Thesis, Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-72044.
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Too few documentative descriptions exist from the reactivated Proterozoic Nasa Basement window in Sweden. This re-exposed crustal piece predominantly consisting of 1.8 Ga granite and volcanic basement rock lack structural evidences on maps. The Western Gneiss region gave example of how rocks in extreme cases may experience protolith overprinting through collisional vertical granite basement subduction to eclogite ambient conditions, which would give traces in metamorphic quartz (coesite), muscovite, pyroxene and kyanite, and increased densities. Preliminary indications from literature points towards a locally passive Nasa Basement with limited translation, but because of too little documentation it cannot be assured metamorphic inertia under fluid absence has been unimportant in the basement evolution. To address this highly structural issue, field reconnaissance mapping and sampling was carried out, and aimed to achieve a structural characterisation of historic deformation back to Proterozoic time. Observations were collected from 166 outcrop vicinities, and 17 of 27 carefully examined thin sections aimed to describe microscopic structures, in addition to mineral relation to metamorphic minerals. Collected evidences in this project encompass a Proterozoic macroscopic concentric fold with axis striking NW-SE, as well as, mesoscopic folds striking WNW-ESE. Tectonic movements record syn-collisional top-SE and post- collisional top-SW translation, which truncate weakly shortened and foliated blocks. Basement blocks locally preserve igneous coarse but weakly recrystallized texture fabrics. Overall optically produced paleothermometry indicates low- to medium grade facies conditions of deformation, through widespread bulging recrystallization, occasional subgrain rotation and rare grain boundary migration in quartz. Feldspar response to deformation is brittle and rarely ductile. Hydrous biotite, chlorite and epidote are abundant. Mineralogy together with an observed average density of 2,6 g/cm3 can possibly reject the idea of unreacted local continental subduction to eclogite depths, due to the overall presence of hydrous mineral phases. Top-to-the shear sense proves Caledonian reactivation, but Bourguer anomaly indicates at least locally an important limited translation. NW-SE striking lineaments and strikes of foliation show best accordance with lineaments mapped in Norway and alignment with tectonic contacts in the Baltica interior, and do so show the best examples of candidates for Proterozoic structures.
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Grant, Derrick Shawn. "The application of immunogold histochemistry to the quantitative analyses of basement membranes /." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75748.
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The objective of the thesis was to examine the distribution, biogenesis and assembly of basement membrane components in situ. This goal was achieved by immunolocalizing laminin, collagen IV, heparan sulfate proteoglycan and other components using 5 and 15nm colloidal gold particles.The distribution of these components, showed them to be ubiquitously localized throughout the thickness of all basement membranes examined. In "thick" basement membranes: Reichert's membrane and the matrix of the mouse EHS tumor, and in the "thin" common basement membranes, the components were localized to the cord network (Inoue et al., 1985). Despite some variations between tissues, quantitation of gold particles indicated a tendency for the molar ratio of laminin:collagen:proteoglycan to be 1:1:0.2 in the thick and 1:1:1 in the thin basement membranes.
The biogenesis of laminin and collagen IV was examined in the endodermal cells producing Reichert's membrane. Both were co-localized in the rough endoplasmic reticulum, Golgi apparatus and secretory granules, corresponding to the pathway followed during processing.
Since the components are believed to self-aggregate after secretion, the molar ratios were used as guidelines to combine the three molecules in vitro, at 35$ sp circ$C. A precipitate formed, which in the electron microscope showed three main structures, one of these had the thickness, immunohistochemical and fine, ultrastructural characteristics of authentic basement membrane. Hence, basement membrane was reconstructed in vitro.
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Muir, Roderick John. "The precambrian basement and related rocks of the southern Inner Hebrides, Scotland." Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339724.
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Levy, Somin Gabriel. "The iridocorneal-endothelial syndrome : a study of cell and basement membrane pathology." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309311.
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Pereira, Inês Tavares Pinto de Sá. "Basement membrane alterarions in kernicteric brain microvasculature and pericyte response to bilirubin." Master's thesis, FCT-UNL, 2011. http://hdl.handle.net/10362/6771.
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Dissertação para obtenção do Grau de Mestre em
Genética Molecular e BiomedicinaKernicterus is a neuropathological condition characterized by deposition of unconjugated bilirubin (UCB) in specific brain regions that can lead to permanent sequelae and death, particularly in premature infants. UCB-induced toxicity has been studied in nerve and glial cells and, more recently, in brain microvascular endothelial cells. However, the effects of UCB on pericytes or on the basement membrane were never reported. We performed in vitro studies to assess apoptotic death, nitrosative stress and inflammatory reaction elicited by human brain vascular pericytes exposed to UCB. We also assessed the basement membrane component, collagen type IV, in brain sections of cortex, basal nuclei,hippocampus and cerebellum, collected at autopsy of a kernicteric preterm newborn. Using the pericyte marker, α-smooth muscle actin, we characterized the cells and confirmed the normal outgrowth towards a typical morphology with long processes. UCB induced an early secretion of interleukin-6, followed by that of vascular endothelial growth factor. mRNA upregulation preceded the secretion and confirmed the precocious profile of IL-6. UCB also caused the release of nitrites, which was maximum at 72 h incubation. The earlier upregulation of endothelial nitric oxide synthase expression confirmed the induction of nitric oxide production by UCB, although not excluding that other isoforms of the enzyme are also involved. Probably as a corolary of all these events, apoptotic cell death occurs in a time- and concentration-dependent manner. Through immunohistochemistry we examined the area occupied and the immunoreactivity of collagen type IV, which were reduced in the kernicterus case as compared with a non-icteric control. These findings are the first to demonstrate the compromise of pericytes and the impairment of collagen IV by hyperbilirubinemia and raise some basis for creation of possible target-directed therapy against pericyte and basement membrane damages as a result of UCB exposure.
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Würsten, Felix. "The Precambrian crystalline basement of Salalah (Dhofar area, Sultantate [sic] of Oman) /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Stokes, Martin. "Plio-Pleistocene drainage evolution of the Vera Basin, SE Spain." Thesis, University of Plymouth, 1997. http://hdl.handle.net/10026.1/1289.
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The Vera Basin is used as a case study to examine the structural evolution and sedimentary response of a basin undergoing uplift and inversion during the Plio-Pleistocene. Particular emphasis is placed on the drainage evolution during that period. Located within the Internal zone of the Betic Cordilleras, the Vera Basin is defined within a large left-lateral shear zone and has evolved as a reponse to isostatic uplift from nappe emplacement during the Oligocene, and by regional compressive tectonics. Since basin formation during the Seravallian, sedimentary fill has been dominantly marine. During the Plio-Pleistocene a switch from marine to continental conditions occurred. These sediments (Cuevas, Espiritu Santo and Salmerbn Formations) represent the final stages of basin fill and form the focus of this study. The Cuevas Formation represents an early Pliocene marine transgression within the Vera Basin. Early sedimentation mulled a pronounced submarine topography produced by a rapid late Miocene fall in sealevel. A broad, shallow shelf platform area existed which opened out to the Pliocene Mediterranean Sea towards the east. Along the northern and western basin margins, wave dominated shorelines were formed. Structural activity was confined to low amounts of basin subsidence and limited left lateral strike-slip movement along the Palomares Fault Zone. The Espiritu Santo Formation marks a major palaeogeographic reorganisation and the final marine phases of the Vera Basin during the mid to late Pliocene. Unsteady strike-slip movement along the Palomares fault zone on the eastern basin margin partially enclosed the Vera Basin by northwards movement of a structurally detached landmass. Gilbert-type fan-delta bodies prograded westwards from the landmass (Sierra Almagrera), infilling the central region of the basin. Early fan-delta sediments were reworked into shoreline areas along the western and northern basin margins. Western margin shorelines retreated northwards as a response to partial enclosure and a gradual lowering of sea-level. Late stages of the Espiritu Santo Formation, saw a fan-delta body prograde from the northern basin margins. Interaction between the basinal and marginal fan-delta bodies enclosed the northern region of the Vera Basin. A swamp/mangrove environment developed within the enclosed northern basin area suggesting a humid, sub-tropical climate. Continental conditions were established during Salmerön Formation times in the late Pliocene. Along the western and northern basin margins, the retreating Pliocene shorelines provided a topography onto which the primary consequent drainage network developed. Three separate drainage systems can be identified on the basis of clast assemblages, palaeocurrents, depositional style and morphological expression. Early deposition was characterised by the progradation of alluvial fans of two drainage systems (Cuevas & Jauro), sourced from the northern and western basin margins. Distal areas of the northern fan system intercalated with an evaporitic playa lake. A third drainage system in the northwest of the basin (Salmerbn) developed within a topographic low between the two fan systems. An increase in structural activity towards the end of the Salmerbn Formation was characterised by a basin wide phase of north-south compression. Uplift and extensional faulting lead to abandonment of the primary drainage network. Fan entrenchment and minor rerouting of sediment supplies marked the establishment of a new secondary consequent drainage network during the Pleistocene. The Pleistocene drainage network records the progressive dissection of the Vera Basin as a response to ongoing regional epeirogenic uplift. During this post-inversion phase the Rios Antas, Almanzora and Aguas developed respectively along the western, northern and southern basin margins as- a series of braided streams. Distal, coastal areas of this drainage network are recorded by a series of Pleistocene shoreline sequences which developed as a response to fluctuating sea-level during the Pleistocene glacial and interglacial periods. Early Pleistocene proximal parts of the drainage network are well preserved. Distal parts of the Pleistocene fluvial system display limited evidence for interaction between the drainage network and shoreline sequences. This lack of preservation relates to the high energy, wave dominated depositional setting of the Pleistocene shoreline areas which reworked fluvial sediment inputs into the shoreline environment. The Plio-Pleistocene evolution of the Vera Basin, and in particular the development of the fluvial during system this period has been highly complex. Despite the importance of sea-level and climatic controls, tectonic activity during this period of basin inversion has been the dominant control on the positioning of the drainage networks, depositional styles and sediment supply.
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Wheatcroft, Alison Clare. "Detection of type IV collagen degradation in inflammatory bowel disease." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310765.
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Garton, Rosemary Louise. "The influence of basement membrane proteins on re-vascularization networks formed after acute injury." Thesis, The University of Sydney, 1997. http://hdl.handle.net/2123/4817.
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Chen, Dongqing. "Cretaceous stratigraphy and basement influences, Peace River Arch region, Western Canada Sedimentary Basin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0009/NQ60210.pdf.
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Walton, H. A. "The effect of structural modifications on the permeation properties of renal basement membrane." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382711.
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Sleight, Janine Michelle. "Fracture characteristics from two reactivated basement fault zones : examples from Norway and Shetland." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/4140/.
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Detailed analyses of fracture attributes developed in basement rocks associated with two, crustal-scale faults, have enabled the characteristics and evolution of the fracture system geometry to be documented quantitatively. Data sets of fracture attributes have been collected adjacent to faults within the Møre-Trøndelag Fault Complex (MTFC) in Central Norway, and the Walls Boundary Fault System (WBFS) in Shetland. Both structures are of Palaeozoic origins and contain multiply reactivated fault strands that extend offshore to bound several hydrocarbon-rich sedimentary basins of Mesozoic-Cenozoic age along the North Atlantic margin. Fracture characteristics from the MTFC were measured within one dominant lithology (acid gneiss) and therefore each data set of fracture characteristics is directly comparable. A number of different fracture parameters were measured using either 1-D or 2-D techniques and were collected over four data scales. These data indicate different signatures for the two main faults within the MTFC: the Verran Fault (VF), a highly reactivated structure and the Hitra-Snasa Fault (HSF), which has experienced little reactivation, and also for a smaller, kinematically simple fault, the Elvdalen Fault (EF). The parameters measured are the exponent values from exponentially distributed spacing and length data sets, mean fracture spacing, fracture density, mean fracture length, fracture intensity and fracture connectivity (defined by the numbers of fractures and nodes per cluster, fracture cluster length and the number of nodes per unit area). Based on analyses of these parameters, the VF is characterised by a tall peak in values (or trough for measurements such as mean length and mean spacing), with a wide zone (-500m) of above-background values to the NW of the Verran Fault Plane. The HSF on the other hand is characterised by a tall and narrow zone of above-background values (or below for mean spacing and mean length parameters), which decrease to background levels within 100m either side of the Hitra- Snasa Fault Plane. The EF is also characterised by a narrow but shorter peak in above background values, where the height of the peak is less than half that associated with the VF and HSF. These different signatures are most likely to be related to the differing reactivation histories between the three faults. In addition, the VF shows widespread evidence for multiple phases of fluid-related alteration and mineralisation, suggesting that the fracture network characteristics play an important role in controlling fluid flow in these otherwise relatively impermeable basement rocks. The data sets of fracture characteristics collected adjacent to four faults within the WBFS display general trends consistent with the changes in fracture attributes observed adjacent to faults within the MTFC. However, the results are considered to be less reliable. Firstly, the data sets were collected within seven different lithologies, meaning that the fracture attributes must be considered separately, resulting in small data sets compared to those collected from gneisses within the MTFC. In addition, the four faults studied all have different kinematic histories. The findings of this study show that detailed studies of fractures may potentially be used to fingerprint fault reactivation and enable its' recognition in the subsurface.
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McGrath, John Alexander. "Abnormalities of wound healing and basement membrane zone composition in dystrophic epidermolysis bullosa." Thesis, King's College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343791.
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Fields, Christopher J. "Functional and Expression Analysis of a Novel Basement Membrane Degrader in Drosophila Melanogaster." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1633.
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The Srivastava Lab is focused on the identification and characterization of genes that play a role in basement membrane remodeling. Previously, we identified putative basement membrane degraders through a genetic screen. One such gene has been suggested to play a role in the maintenance of the stem cell niche in Drosophila melanogaster, but no other information about the role this gene plays in development or disease has been published. Here, data are presented from experiments utilizing Drosophila genetics and immunohistochemistry that provide important insights on the biological role of this gene.
Collagenase activity was up-regulated upon overexpression of this gene, confirming it as a basement membrane degrader. Additionally, RNA in-situ hybridization experiment results showed expression in the developing imaginal discs of the 3rd instar larva tissues. Overexpression and knockdown studies further demonstrated morphological defects in a number of tissues, including the wing and the eye, and are suggestive of apoptosis. Acridine orange staining confirmed that cell death occurred when the gene was overexpressed and a cleaved caspase antibody staining indicated that process to be caspase-mediated apoptosis.
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Butler, Christopher Anthony. "Basement fault reactivation : the kinematic evolution of the Outer Hebrides Fault Zone, Scotland." Thesis, Durham University, 1995. http://etheses.dur.ac.uk/1427/.
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Orme, Devon A., William R. Guenthner, Andrew K. Laskowski, and Peter W. Reiners. "Long-term tectonothermal history of Laramide basement from zircon–He age-eU correlations." ELSEVIER SCIENCE BV, 2016. http://hdl.handle.net/10150/621920.
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The long-term (>1 Ga) thermal histories of cratons are enigmatic, with geologic data providing only limited snapshots of their evolution. We use zircon (U-Th)/He (zircon He) thermochronology and age composition correlations to understand the Proterozoic-Phanerozoic thermal history of Archean Wyoming province rocks exposed in the northern Laramide ranges of western North America. Zircon He ages from the Wind River Range (54 dates) and Bighorn Mountains (32 dates) show negative correlations with effective uranium (eU), a proxy for radiation damage. Zircon dates from the Bighorns are between 960 Ma (low-eU) and 20 Ma (high-eU) whereas samples from the Wind Rivers are between 582 Ma (low-eU) and 33 Ma (high-eU). We applied forward modeling using the zircon radiation damage and annealing model ZrDAAM to understand this highly variable dataset. A long-term t-T path that is consistent with the available geologic constraints successfully reproduced age-eU correlations. The best fit to the Wind Rivers data involves two phases of rapid cooling at 1800-1600 Ma and 900-700 Ma followed by slower cooling until 525 Ma. During the Phanerozoic, these samples were heated to maximum temperatures between 160 and 125 degrees C prior to Laramide cooling to 50 degrees C between 60 and 40 Ma. Data from the Bighorn Mountains were successfully reproduced with a similar thermal history involving cooler Phanerozoic temperatures of similar to 115 degrees C and earlier Laramide cooling between 85 and 60 Ma. Our results indicate that age-eU correlations in zircon He datasets can be applied to extract long-term thermal histories that extend beyond the most recent cooling event. In addition, our results constrain the timing, magnitude and rates of cooling experienced by Archean Wyoming Province rocks between recognized deformation events, including the >1 Ga period represented by the regionally-extensive Great Unconformity.
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Falcone, Sara. "Nephrotic syndrome and glomerular basement membrane : genetic defect of the laminin α5 chain." Thesis, Open University, 2018. http://oro.open.ac.uk/56060/.
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Nephrotic syndrome is a heterogeneous group of disorders characterised by renal and extra-renal manifestations. Classic symptoms of nephrotic syndrome include severe proteinuria, hypoalbumiaemia, oedema and hyperlipidaemia. Genetic studies of hereditary forms of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signalling, regulation of actin cytoskeleton dynamics and cell-matrix interactions. The laminin α5 chain is a 404 kDa protein essential for embryonic development and, in association with laminin β2 and laminin γ1, it is a major component of the glomerular basement membrane. Mutations in LAMB2 are associated with Pierson’s syndrome and mutations in LAMA5 have recently been identified in paediatric patients affected by nephrotic syndrome. As part of the MRC Harwell Ageing Screen, a large-scale ENU mutagenesis screen, a novel missense mutation (E884G) was identified in the gene Lama5. Homozygous mice showed a nephrotic phenotype including a severe proteinuria that preceded histological and ultrastructural changes. Further investigation using in vitro studies, extensive proteomics analysis and investigation of integrin activation, revealed a possible impact of the causative mutation on protein folding. Data suggest that changes in protein structure lead to a reduced secretion, integrin β1 activation, and agrin expression ultimately resulting in possible instability of the podocyte actin cytoskeleton.
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Aypek, Hande [Verfasser]. "Loss of P3h2 gene causes thin basement membrane nephropathy in mice / Hande Aypek." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/124083554X/34.
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Goddard, James V. "Internal Deformation, Evolution, and Fluid Flow in Basement-Involved Thrust Faults, Northwestern Wyoming." DigitalCommons@USU, 1993. https://digitalcommons.usu.edu/etd/6697.
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An integrated field , microstructure, fracture statistic , geochemistry , and laboratory permeability study of the East Fork and White Rock fault zones , of similar age and tectonic regime but different structural level and hydrogeologic history , provides detailed information about the internal deformation and fluid flow processes in fault zones . The primary conclusions of this research are: 1) Fault zones can be separated into subzones of protolith, damaged zone , and gouge /cataclasite , based on physical morphology and permeability structure . At deep structural levels, gouge/cataclasite zones are more evolved (thicker with increased grain size reduction) due to strain localization , higher pressure and temperature, and fluid/rock interaction ; 2) Deformation mechanisms evolved from primarily brittle fracturing and faulting in the damaged zone to extreme, fluid-enhanced chemical breakdown and cataclasis which localized strain in the fault core. Deformation in the deep-level-fault core may be a combination of frictional and quasiplastic mechanisms, and is largely controlled by extremely fine-grained clays, zeolites , and other phyllosilicates that may have acted as a thermally pressurized, fluid-saturated lubricant; 3) Permeability in fault zones was temporally heterogeneous and anisotropic (permeability of damaged zone>protolith>gouge /cataclasite, permeability along fault> permeability across fault); 4) Volume loss was concentrated in the fault cores and was negligible at intermediate structural
levels and high at deep structural levels in the semi-brittle to brittle regime ; 5) Fluid flow and solute transport were concentrated upwards and subparallel to the fault in the damaged zone ; 6) Faults at both the local and regional scale acted as fluid flow conduit/barrier systems depending upon the evolutionary stage and interval in the seismic cycle ; 7) Fluid/rock volume ratios , fluid flux , and fluid/rock volume ratios over time ranged from ⋍ 103 to 104, 10-6 ms-1 to 10-9 ms-1, and 0.05 L/m3 rock•yr to 0.50 L/m3 rock•yr, respectively, suggesting that enormous quantities of fluids passed through the fault zones; 8) Box counting fractal analyses of fault zone fractures showed that fracture spatial and density distribution is scale-invariant at the separate scales of outcrop , hand-sample , and thin section, but self-affine from outcrop to thin-section scale; 9) Linear fractal analysis depicts clustering and density distribution as a function of orientation, and may be a quick, robust method of estimating two-dimensional fracture permeability; and 10) Fractal analysis of fractures is not a comprehensive statistical method, but can be used as another supplemental statistical parameter.
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Niemelä, Onni. "Aminoterminal propeptide of type III procollagen and basement related antigens in alcoholic liver disease." Oulu : University of Oulu, 1985. http://catalog.hathitrust.org/api/volumes/oclc/14472875.html.
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Gaab, Andreas S. "Isotope geochemical and geochronologic studies of basement units in the Central Western Carpathians (Slovakia)." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975961136.
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Edwards, Darran Jones. "An integrated geophysical investigation of basement controls on Devonian carbonates in central Alberta, Canada." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24535.pdf.
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