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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Wang, Danni, Danbo Wang, Ning Wang, Zaiqiu Long, and Xuemei Ren. "Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway." Cellular Physiology and Biochemistry 40, no. 3-4 (2016): 644–56. http://dx.doi.org/10.1159/000452577.

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Background/Aims: Microarray screening had found BRAF-activated non-coding RNA (BANCR) was significantly upregulated in type 1 endometrial cancer (EC). This study aimed to assess the potential role of long non-coding RNA (lncRNA) BANCR in the pathogenesis and progression of type 1 EC. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to confirm the expression of BANCR in type 1 EC tissue, and analyze its clinical significance. In vitro, RNA interference (siRNA) was used to investigate the biological role of BANCR in type 1 EC. Results: qRT-PCR revealed that the expression of lncRNA BANCR was higher in type 1 EC (P<0.01). BANCR expression was significantly correlated with FIGO stage, pathological grade, myometrial invasion, and lymph node metastasis. The expression of BANCR was significantly correlated with that of MMP2/MMP1. In vitro, knockdown of BANCR significantly suppressed proliferation, migration, and invasion of Ishikawa and HEC-1A cells, and significantly inhibited the ERK/MAPK signaling pathway that decreased MMP2 and MMP1 expression. Conclusion: BANCR is highly expressed in type 1 EC tissue and promotes EC-cell proliferation, migration, and invasion by activating ERK/MAPK signaling pathway that regulates MMP2/MMP1 expression. BANCR is expected to become a prognostic marker and therapeutic target in type 1 EC.

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2

McCarthy, Nicola. "Going places with BANCR." Nature Reviews Cancer 12, no. 7 (June 7, 2012): 451. http://dx.doi.org/10.1038/nrc3302.

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3

Liu, Lixue, Ru Bai, Debang Li, Bai Dai, and Ya Tuo. "LncRNA BANCR Promotes Endometrial Stromal Cell Proliferation and Invasion in Endometriosis via the miR-15a-5p/TRIM59 Axis." International Journal of Genomics 2022 (October 10, 2022): 1–13. http://dx.doi.org/10.1155/2022/9083822.

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Long non-coding RNA (LncRNA) emerges as a regulator in various diseases, including endometriosis (EM). This study aims to uncover the role of long non-coding RNA BRAF-activated non-protein coding RNA (lncRNA BANCR)-mediated competing endogenous RNA mechanism in endometrial stromal cell (ESC) proliferation and invasion in EM by regulating miR-15a-5p/TRIM59. ESCs were isolated from eutopic and ectopic endometrial tissues, followed by the determination of Cytokeratin 19 and Vimentin expressions in cells. Then, expressions of lncRNA BANCR, microRNA (miR)-15a-5p, and tripartite motif-containing 59 (TRIM59) in tissues and cells were determined by real-time quantitative polymerase chain reaction or Western blot assay, and cell proliferation and invasion were evaluated by cell counting kit-8 and transwell assays. After that, the subcellular localization of lncRNA BANCR and binding of miR-15a-5p to lncRNA BANCR or TRIM59 were analyzed. LncRNA BANCR was upregulated in ectopic endometrial tissues and ectopic ESCs (Ect-ESCs). Silencing lncRNA BANCR suppressed Ect-ESC proliferation and invasion. LncRNA BANCR inhibited miR-15a-5p to promote TRIM59 expression. miR-15a-5p downregulation or TRIM59 overexpression both reversed the effects of silencing lncRNA BANCR on Ect-ESC proliferation and invasion. In summary, our findings suggested that lncRNA BANCR facilitated Ect-ESC proliferation and invasion by inhibiting miR-15a-5p and promoting TRIM59.

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4

Quijano-Célis, Clara E., David Piedrahita, and Jorge A. Pino. "Essential Oil of Arracacia xanthorrhiza Bancr. Leaves from Colombia." Journal of Essential Oil Bearing Plants 19, no. 5 (July 3, 2016): 1296–99. http://dx.doi.org/10.1080/0972060x.2016.1195710.

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5

Contiero, Jonas. "Caracterização físico-química do amido de mandioquinha-salsa (Arracacia xanthorrhiza bancr.)." Eclética Química Journal 18, no. 1 (June 14, 2018): 101. http://dx.doi.org/10.26850/1678-4618eqj.v18.1.1993.p101-112.

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6

Zou, Yifan, Jianfa Li, Yincong Chen, Huizhong Xiao, Fuyou Zhang, Dan Yu, and Kewang Luo. "BANCR: a novel oncogenic long non-coding RNA in human cancers." Oncotarget 8, no. 55 (October 24, 2017): 94997–5004. http://dx.doi.org/10.18632/oncotarget.22031.

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7

Ma, Siping, Dongxiang Yang, Yanlong Liu, Yongpeng Wang, Tao Lin, Yanxi Li, Shihua Yang, Wanchuan Zhang, and Rui Zhang. "LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer." Aging 10, no. 8 (August 22, 2018): 2062–78. http://dx.doi.org/10.18632/aging.101530.

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8

Aksoy, Fuat, Halit Ziya Dundar, Secil Ak Aksoy, Berrin Tunca, Pinar Tasar, Yilmaz Ozen, Gulsah Cecener, et al. "Long noncoding RNA BANCR predicts poor clinical outcome in periampullary tumors." International Journal of Surgery 75 (March 2020): S4—S5. http://dx.doi.org/10.1016/j.ijsu.2020.01.035.

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9

Li, He, Xian Liu, Lan Zhang, and Xueqi Li. "LncRNA BANCR facilitates vascular smooth muscle cell proliferation and migration through JNK pathway." Oncotarget 8, no. 70 (October 7, 2017): 114568–75. http://dx.doi.org/10.18632/oncotarget.21603.

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10

Wang, Hongli, Na Zhang, Guiru Li, and Bing Xu. "Proinflammatory cytokine IFN-γ, lncRNA BANCR and the occurrence of coronary artery disease." Life Sciences 231 (August 2019): 116510. http://dx.doi.org/10.1016/j.lfs.2019.05.066.

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11

Zhao, Jun, Yali Qi, Jiahao Hu, Wenwen Dai, and Yifei Chen. "Prognostic Role of Long Noncoding RNA BANCR in Solid Tumors: A Meta-Analysis." Technology in Cancer Research & Treatment 16, no. 6 (December 2017): 727–35. http://dx.doi.org/10.1177/1533034617748075.

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12

Quilapanta, Rodrigo, Marta Dávila, Carlos Vásquez, and Vanessa Frutos. "Morphotypes of Arracacia xanthorrhiza Bancr. (White carrot) from Ecuador, as a source of germplasm variability." Scientia Agropecuaria 9, no. 2 (June 29, 2018): 281–86. http://dx.doi.org/10.17268/sci.agropecu.2018.02.13.

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13

Wilson, Kitchener D., Mohamed Ameen, Hongchao Guo, Oscar J. Abilez, Lei Tian, Maxwell R. Mumbach, Sebastian Diecke, et al. "Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates." Developmental Cell 54, no. 6 (September 2020): 694–709. http://dx.doi.org/10.1016/j.devcel.2020.07.006.

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14

GARNICA MONTAÑA, JOHANNA PAOLA, OSCAR JAIR RODRIGUEZ RODRIGUEZ, CAMILO IGNACIO JARAMILLO BARRIOS, and FRANCO ALIRIO VALLEJO CABRERA. "Diversidad morfológica y caracteres de selección del germoplasma de arracacha (Arracacia xanthorriza Bancr.) en Colombia." Ciencia y Agricultura 17, no. 3 (August 25, 2020): 49–62. http://dx.doi.org/10.19053/01228420.v17.n3.2020.11150.

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La arracacha se ha convertido en parte importante de la alimentación en la zona andina de Suramérica con gran arraigo cultural. Sin embargo, la única variedad regional cultivada en más del 90 % del país se denomina amarilla común, un material sembrado durante más de 30 años que ha disminuido su potencial productivo dejando a los productores sin otras alternativas. El 94.6 % de las accesiones de arracacha conservadas por el Sistema de Bancos de Germoplasma de la Nación para la Alimentación y la Agricultura (SBGNAA) de Colombia corresponden a colectas nacionales. La identificación y la evaluación del recurso genético permiten identificar los rasgos de selección deseados para futuros proyectos de mejoramiento. 96 accesiones fueron caracterizadas durante el 2016, se observó amplia variabilidad en 11 caracteres cuantitativos y 30 cualitativos. Mediante análisis factorial para datos mixtos (AFDM) y análisis de clúster, se determinaron seis grupos completamente diferenciados según el porte de la planta, el cual estuvo influenciado por las variables altura y diámetro de la planta, longitud del pecíolo, longitud y ancho de la hoja. Las variables cualitativas más importantes correspondieron a color de pulpa de la raíz reservante, pigmentación secundaria de hojas, color secundario del pecíolo y capacidad de florecimiento, convirtiendo estos atributos en factores de selección. El color de la pulpa de la raíz reservante se convirtió en un carácter de selección debido a que en muchas comunidades de la zona andina los materiales son fácilmente distinguibles por el color de la pulpa del nabo.

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15

Zhang, Jinjun, Yaying Du, Xiaoxue Zhang, Mengchen Li, and Xingrui Li. "Downregulation of BANCR Promotes Aggressiveness in Papillary Thyroid Cancer via the MAPK and PI3K Pathways." Journal of Cancer 9, no. 7 (2018): 1318–28. http://dx.doi.org/10.7150/jca.20150.

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16

Jiang, Wenjun, Dandan Zhang, Baoning Xu, Zhuo Wu, Siyang Liu, Lei Zhang, Ye Tian, Xu Han, and Dali Tian. "Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways." Biomedicine & Pharmacotherapy 69 (February 2015): 90–95. http://dx.doi.org/10.1016/j.biopha.2014.11.027.

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17

Li, Ruiya, Lingli Zhang, Lizhou Jia, Yan Duan, Yan Li, Lidao Bao, and Na Sha. "Long Non-Coding RNA BANCR Promotes Proliferation in Malignant Melanoma by Regulating MAPK Pathway Activation." PLoS ONE 9, no. 6 (June 26, 2014): e100893. http://dx.doi.org/10.1371/journal.pone.0100893.

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18

Contreras-Santos, Jose Luis, Jorge Enrique Villamil-Carvajal, Johanna Paola Garnica-Montaña, and Liliana Margarita Atencio-Solano. "Evaluación de los componentes químicos del suelo en el sistema productivo de arracacha en Cajamarca, Colombia." Revista Mexicana de Ciencias Agrícolas 13, no. 7 (November 22, 2022): 1171–82. http://dx.doi.org/10.29312/remexca.v13i7.3072.

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El cultivo de arracacha (Arracacia xanthorrhiza Bancr.) hace parte de la cultura culinaria y economía andina de Colombia, su importancia radica en ser una fuente primordial en la dieta y nutrición campesina. La baja tecnificación del cultivo, asociado a prácticas inadecuadas de manejo de suelo, ha generado estancamiento en los rendimientos regionales, lo que ha generado aumento en la brecha de conocimiento tecnológico entre los productores. Por tal razón, el objetivo del presente estudio fue evaluar las propiedades químicas del suelo, bajo el sistema de producción de arracacha (Arracacia xanthorrhiza Bancr.) e identificar las principales limitantes químicas del suelo, que afectan el rendimiento en el cultivo, en el municipio de Cajamarca, Tolima. Se tomaron muestras de suelos durante la época de transición seco-lluviosa en 50 predios distribuidos en 17 veredas del municipio, sobre las que se evaluaron los parámetros químicos de suelos, así mismo, se estimó la producción de raíces tuberosas con base en la densidad de siembra promedio de la región de 16 666 plantas ha-1. Se observó que 81% de los predios evaluados presentaron reacción acida (5.25 ±0.15 a 6.6 ±1.1), contenido de materia orgánica (MO) en rango medio (>3%) y capacidad de intercambio catiónico (CIC) con valores bajos (3.31 ±0.64 a 15.35 ±10.25 cmol kg-1). El rendimiento de raíces tuberosas en fresco estuvo condicionado a la presencia de los contenidos de MO, calcio (Ca) y potasio (K) intercambiable en el suelo. Los resultados obtenidos evidenciaron procesos de degradación química del suelo asociados a la fertilización implementada por los productores en la región.

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19

Wang, Bing, Min Wang, Shuzhao Jia, Tao Li, Mingkun Yang, and Feng Ge. "Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells." Journal of Proteome Research 21, no. 4 (March 7, 2022): 1137–52. http://dx.doi.org/10.1021/acs.jproteome.2c00009.

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20

Li, Ling, Lei Zhang, Yan Zhang, and Fang Zhou. "Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer." Biomedicine & Pharmacotherapy 72 (May 2015): 109–12. http://dx.doi.org/10.1016/j.biopha.2015.04.007.

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21

Zhang, Zhi-Xin, Zhi-Qiang Liu, Biao Jiang, Xin-Yang Lu, Xiao-Fei Ning, Chuan-Tao Yuan, and Ai-Liang Wang. "BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1." Biochemical and Biophysical Research Communications 465, no. 2 (September 2015): 225–31. http://dx.doi.org/10.1016/j.bbrc.2015.07.158.

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22

Sadeghpour, Shiva, and Saeid Ghorbian. "Evaluation of the potential clinical prognostic value of lncRNA-BANCR gene in esophageal squamous cell carcinoma." Molecular Biology Reports 46, no. 1 (December 14, 2018): 991–95. http://dx.doi.org/10.1007/s11033-018-4556-2.

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23

Wu, Xinquan, Tianfang Xia, Meng Cao, Pengbo Zhang, Guodong Shi, Lei Chen, Jingjing Zhang, et al. "LncRNA BANCR Promotes Pancreatic Cancer Tumorigenesis via Modulating MiR-195-5p/Wnt/β-Catenin Signaling Pathway." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381988796. http://dx.doi.org/10.1177/1533033819887962.

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Long noncoding BRAF-activated noncoding RNA has been reported to be tightly associated with tumorigenesis and development in various types of cancers. However, the expression, biological function, and modulatory mechanism of BRAF-activated noncoding RNA in pancreatic cancer remained unclear. In the present work, we explored the carcinogenic activity and underlying mechanism of BRAF-activated noncoding RNA on pancreatic cancer in vitro. We identified that BRAF-activated noncoding RNA was upregulated in pancreatic cancer tissues and cell lines, and BRAF-activated noncoding RNA was related to tumor metastasis and stage. BRAF-activated noncoding RNA reinforces proliferation, invasion, and migration in PANC-1 and SW1990 cells. Moreover, miR-195-5p was downregulated in both PC tissues and cell lines. Our results based on luciferase reporter, RIP-Ago2 and qRT-PCR assays, showed that miR-195-5p was a direct target of BRAF-activated noncoding RNA. Furthermore, miR-195-5p inhibitor abrogated the effects of short-interfering BRAF-activated noncoding RNA on PANC-1 and SW1990 cell growth and invasion in vitro. We further identified that BRAF-activated noncoding RNA played a vital role in activating the Wnt/β-catenin pathway by sponging miR-195-5p. Collectively, our study showed that BRAF-activated noncoding RNA promotes pancreatic cancer tumorigenesis through miR-195-5p/Wnt/β-catenin axis may serve as a potential target for diagnostics and therapeutics in pancreatic cancer.

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Miao, Xiang, Yixiang Liu, Yuzhu Fan, Guoqiang Wang, and Hongbo Zhu. "LncRNA BANCR Attenuates the Killing Capacity of Cisplatin on Gastric Cancer Cell Through the ERK1/2 Pathway." Cancer Management and Research Volume 13 (January 2021): 287–96. http://dx.doi.org/10.2147/cmar.s269679.

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Shi, Yongguo, Yangchen Liu, Jirong Wang, Ding Jie, Tian Yun, Wang Li, Lin Yan, Keming Wang, and Jifeng Feng. "Downregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression." PLOS ONE 10, no. 4 (April 30, 2015): e0122679. http://dx.doi.org/10.1371/journal.pone.0122679.

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26

Su, Shizheng, Jian Gao, Tao Wang, Ju Wang, Hong Li, and Zhen Wang. "Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma." Tumor Biology 36, no. 9 (April 19, 2015): 7205–11. http://dx.doi.org/10.1007/s13277-015-3413-3.

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27

Yang, Chunxia, Yue Wang, Fangjun Chen, Yongzhong Hou, Jianhua Jin, and Qian Liu. "BRAF-activated non-protein coding RNA (BANCR) advances the development of esophageal squamous cell carcinoma via cell cycle." Open Life Sciences 12, no. 1 (April 30, 2017): 128–34. http://dx.doi.org/10.1515/biol-2017-0015.

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AbstractEsophageal carcinoma is one of the important lethal tumors in the world, but the mechanism of esophageal cancer progression is still unclear. The long non-coding RNAs are known to regulate tumor progression. Here we report that BRAF-activated nonprotein coding RNA (BANCR) is associated with the development of esophageal squamous cell carcinoma (ESCC). The expression levels ofBANCRin 132 ESCC tumor tissues detected by quantitative real-time PCR were significantly higher than that in the adjacent normal tissues. The expression level ofBANCRwas down-regulated by transfecting small interrupting RNA againstBANCR(BANCRsiRNA) in Eca109 cells. Eca109 and TE-1 cells transfected withBANCRsiRNA led to the delayed cell cycles compared to the cells transfected with negative control siRNA. Moreover, MTT assays demonstrated that Eca109 cells transfected withBANCRsiRNA resulted in the inhibition of cell proliferation. These results suggested thatBANCRadvances the development and progression of ESCC cells through regulating their cell cycles.

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Chen, Quan, Yiming Zheng, Bingbing Wu, Xia Chen, Fei Sun, Pengfei Ge, and Pengcheng Wang. "BANCR Regulates The Cell Invasion And Migration In Esophageal Squamous Cell Carcinoma Through Wnt/β-Catenin Signaling Pathway." OncoTargets and Therapy Volume 12 (November 2019): 9319–27. http://dx.doi.org/10.2147/ott.s227220.

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29

Carrero, Yenddy, Jenny Moya, Michael Acosta, and Jesús Mosquera-Sulbarán. "Arracacia xanthorrhiza Bancr compounds decrease β-actin, hypoxia-inducible factor-1 and nitric oxide production in HeLa cells." Investigación Clínica 63, no. 1 (March 23, 2022): 7–18. http://dx.doi.org/10.54817/ic.v63n1a01.

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The treatment of cancer patients with anti-cancer drugs is often accompanied by the presence of undesirable side effects. The use of natural plant derivatives alone, or in conjunction with existing anti-neoplastic drugs, has been suggested to obtain better results and decrease these side effects. Nitric oxide (NO•), the hypoxia-inducible factor-1 (HIF-1), and decreased concentration of actin play important roles in cancer progression. The beneficial effects of polyphenols in various organ disorders including cancer has been reported. The aim of this study was to determine the effect of Arracacia xanthorrhiza Bancr extracts, white (WAXB) and red (RAXB) variants (compounds rich in polyphenols) on the concentrations of β-actin, NO• and HIF-1 in Hela cells cultures, to uncover possible anti-neoplastic effects. Extracts from the plant leaves were added to Hela cell cultures at a concentration of 10-3 mg/mL, and after 24 hours of culture, the concentrations of β-actin, NO• and HIF-1 were determined by immunohistochemical, biochemical and western blot assays. Both extracts reduced the concentrations of β-actin, NO• and HIF-1 (p<0.001), similar to the methotrexate effect. These results suggest an antineoplastic effect of the studied plant extracts and highlight the possibility of their use in the treatment of neoplasms.

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Zhou, Meng, Gan Zhang, Jun Hu, Yanzhi Zhu, Haoming Lan, Xianfeng Shen, Yi Lv, and Linsheng Huang. "Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR/miRNA-590-5P/OLR1 Axis." International Journal of Biological Sciences 17, no. 13 (2021): 3595–607. http://dx.doi.org/10.7150/ijbs.62471.

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Toraih, Eman A., Aya El-Wazir, Essam Al Ageeli, Mohammad H. Hussein, Mohamed M. Eltoukhy, Mary T. Killackey, Emad Kandil, and Manal S. Fawzy. "Unleash multifunctional role of long noncoding RNAs biomarker panel in breast cancer: a predictor classification model." Epigenomics 12, no. 14 (July 2020): 1215–37. http://dx.doi.org/10.2217/epi-2019-0291.

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Aim: We aimed to explore the circulating expression profile of nine lncRNAs (MALAT1, HOTAIR, PVT1, H19, ROR, GAS5, ANRIL, BANCR, MIAT) in breast cancer (BC) patients relative to normal and risky individuals. Methods: Serum relative expressions of the specified long non-coding RNAs were quantified in 155 consecutive women, using quantitative reverse-transcription PCR. Random Forest (RF) and decision tree were also applied. Results: Significant MALAT1 upregulation and GAS5 downregulation could discriminate risky women from healthy controls. Overexpression of the other genes showed good diagnostic performances. Lower GAS5 levels were associated with metastasis and recurrence. RF model revealed a better performance when combining gene expression patterns with risk factors. Conclusion: The studied panel could be utilized as diagnostic/prognostic biomarkers in BC, providing promising epigenetic-based therapeutic targets.

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Kutty, R. Krishnan, William Samuel, Todd Duncan, Olga Postnikova, Cynthia Jaworski, Chandrasekharam N. Nagineni, and T. Michael Redmond. "Proinflammatory cytokine interferon-γ increases the expression of BANCR, a long non-coding RNA, in retinal pigment epithelial cells." Cytokine 104 (April 2018): 147–50. http://dx.doi.org/10.1016/j.cyto.2017.10.009.

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Kim, Ji-Yeon, Kyunghee Park, Woong-Yang Park, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jonghan Yu, Young-Hyuck Im, Jin Seok Ahn, and Yeon Hee Park. "Abstract P3-13-08: Fusion analysis including NTRK fusion in breast cancers (BC): From RNASeq data analysis from 629 BC tissue samples." Cancer Research 82, no. 4_Supplement (February 15, 2022): P3–13–08—P3–13–08. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-13-08.

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Abstract Background: Neutrotrophin receptor tyrosine kinase (NTRK) gene fusions (NTRK1, NTRK2, or NTRK3) are oncogenic drivers of various tumor types. The NTRK fusion was detected in less than 5% of breast, colorectal, lung or any other types of cancers. However, large scaled next generation sequencing data for NTRK fusion in breast cancer have not existed. In this study, we performed RNASeq and fusion analysis including NTRK genes. Methods: We prospectively collected BC tumor tissues from the translational research conducted in Samsung Medical Center. Fusion was predicted from RNAseq using the following seven softwares(SWs): ChimeraScan, DeFuse, MapSplice, TophatFusion, STAR.Arriba, STAR.fusion, and STAR.SEQR. To remove false-positive fusion calls, calls less than 3 left/right spanning reads and 10 total supporting reads were removed. After filtering out the blacklist fusion calls which were recurrently detected, calls commonly predicted in more than two SWs were analyzed. Results: In total 629 BC samples, 613 samples were finally analyzed after quality control (QC) of RNASeq. According to immunohistochemistry (IHC) profile, 356(58.7%) was hormone receptor (HR) positive human epidermal growth factor receptor 2 (HER2) negative BC, 42 (6.9%) of HR positive HER2 positive BC, 53 (8.7%) of HR negative, HER2 positive and 155(25.6%) of triple negative BC (TNBC). PAM50 prediction informed that 174(28.9%) of luminal A, 151(24.6%) of luminal B, 170 (27.7%) of basal-like, 85 (13.9%) of HER2-enriched and 33 (5.4%) of normal. In median number of fusion events, 12 was called by ChimeraScan (Interquartile range [IQR]: 5, 33), 57 by DeFuse (IQR: 33, 82), eight by Mapsplice (IQR: 5, 12), two by TophatFusion (IQR: 0, 4), five by STAR.Arriba (IQR: 2, 12), two by STAR.fusion (IQR:0, 5) and three by STAR.SEQR fusion caller (IQR: 1, 7) after call filtering. After initial fusion call, we excluded the results from ChimeraScan and DeFuse fusion callers because of discrepancy of number of called fusion events. In five fusion callers, median number of fusion events was eight (IQR :2,20) per BC sample. In terms of NTRK fusion, we detected NTRK2-BANCR fusion event in one TNBC patients (1/425, 0.2%). This fusion was detected in four of five SWs for fusion detection with significant number of supporting reads in RNASeq. NTRK2-BANCR fusion was the out-of-frame fusion, which C-terminal truncated protein kinase domain of NTRK2 and its partner long non-coding RNA BANCR was combined and RNA expression of this fusion was increased. Other fusion events of BCs were NCOR2-PARP4 (3.7%), BRD4-NWD1 (3.7%), ESR1-RGS17 (1.8%), FGFR1-TACC1 (0.2%) and MKRN1-BRAF (0.2%). In BC subtype according to IHC, fusion events were more frequently observed in TNBC compared with other subtypes regardless of the type of fusion filters. In terms of intrinsic subtype, fusion events were most frequently observed in basal like type and least in normal like intrinsic subtype (all ps<0.05, respectively). Conclusions: In this large scaled RNASeq data analysis, a few fusion events were observed in BC patients. Prevalence of NTRK was extremely rare. Additional investigation including functional validation would be followed. Citation Format: Ji-Yeon Kim, Kyunghee Park, Woong-Yang Park, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jonghan Yu, Young-Hyuck Im, Jin Seok Ahn, Yeon Hee Park. Fusion analysis including NTRK fusion in breast cancers (BC): From RNASeq data analysis from 629 BC tissue samples [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-13-08.

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Liu, Zihao, Tongxin Yang, Zhipeng Xu, and Xiufeng Cao. "Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma." Biomedicine & Pharmacotherapy 82 (August 2016): 406–12. http://dx.doi.org/10.1016/j.biopha.2016.05.014.

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Li, Ai-xiang, Wen-qi Xin, and Chuan-gen Ma. "Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR." Biochemical and Biophysical Research Communications 465, no. 3 (September 2015): 594–600. http://dx.doi.org/10.1016/j.bbrc.2015.08.068.

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Yin, Li, Zhaohui Sun, Qian Ren, Xian Su, and Delong Zhang. "Long Non-Coding RNA BANCR Is Overexpressed in Patients with Diabetic Retinopathy and Promotes Apoptosis of Retinal Pigment Epithelial Cells." Medical Science Monitor 25 (April 18, 2019): 2845–51. http://dx.doi.org/10.12659/msm.913359.

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Stojanović, Stefana, Sonja Šelemetjev, Ilona Đorić, Jelena Rončević, Jelena Janković Miljuš, Vladan Živaljević, and Tijana Išić Denčić. "Elevated BANCR expression levels have different effects on papillary thyroid carcinoma progression depending on the presence of the BRAFV600E mutation." European Journal of Surgical Oncology 46, no. 10 (October 2020): 1835–42. http://dx.doi.org/10.1016/j.ejso.2020.05.027.

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Menegassi, Bruna, Magali Leonel, Martha Maria Mischan, and Sheila Zambello de Pinho. "Efeito de parâmetros de extrusão na cor E propriedades de pasta da farinha de mandioquinha-salsa (Arracacia xanthorrhiza)." Ciência e Agrotecnologia 31, no. 6 (December 2007): 1780–92. http://dx.doi.org/10.1590/s1413-70542007000600027.

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Processou-se neste trabalho a farinha de mandioquinha-salsa (Arracacia xanthorrhiza Bancr.) em uma linha de extrusão (mono rosca) variando as condições operacionais: umidade da farinha (11-19%), temperatura de extrusão (86-154ºC) e taxa de rotação da rosca (136-272rpm). Os parâmetros de cor analisados foram luminosidade (L*) e os componentes de cromaticidade a* e b*. Os parâmetros de propriedade de pasta analisados foram viscosidade inicial, pico de viscosidade, quebra de viscosidade, tendência a retrogradação e viscosidade final. Os resultados obtidos mostraram que a umidade da matéria-prima interferiu nos componentes de cor das farinhas com efeito significativo sobre a luminosidade e croma a*, e a temperatura interferiu no croma b* . Quanto ao efeito dos parâmetros de processo sobre as propriedades de pasta, a umidade interferiu nas viscosidades inicial e final dos produtos, pico e quebra de viscosidade, enquanto a temperatura de extrusão e a rotação da rosca tiveram influência sobre a tendência a retrogradação e viscosidade final dos produtos.

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Yang, Liu, and Guiting Liu. "lncRNA BANCR suppresses cell viability and invasion and promotes apoptosis in non-small-cell lung cancer cells in vitro and in vivo." Cancer Management and Research Volume 11 (April 2019): 3565–74. http://dx.doi.org/10.2147/cmar.s194848.

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Pedreschi, R., I. Betalleluz-Pallardel, R. Chirinos, C. Curotto, and D. Campos. "Impact of cooking and drying on the phenolic, carotenoid contents and in vitro antioxidant capacity of Andean Arracacha (Arracacia xanthorrhiza Bancr.) root." Food Science and Technology International 17, no. 4 (August 2011): 319–30. http://dx.doi.org/10.1177/1082013210382449.

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The influence of different cooking regimes such as boiling, oven, microwave and hot-air drying on the retention of total phenolics (TP), total carotenoids (TC) and in vitro antioxidant capacity (AC) for three colored arracacha roots was studied. Continuous losses of TP, TC and AC during the course of the different cooking processes were observed. Boiling at 99.5° C for 20 min turned to be the best method to cook this root due to a high retention of TP, TC and AC in comparison to oven cooking at 200° C for 45 min and microwave cooking at 800 W for 5 min. During boiling, chlorogenic and caffeic acids and derivatives remained relatively stable. The drying temperature was negatively correlated to the residual content of TP and AC for the yellow and cream arracacha roots, but for the cream/purple arracacha variety, blanching preserved the TP and AC. Significant losses in chlorogenic and caffeic acids and derivatives were mainly observed during hot-air drying. These results suggested that TP are responsible to a large extent of the AC displayed by arracacha root during the different evaluated cooking regimes.

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Morillo, Eduardo, Steen Randers Knudsen, and Gérard Sécond. "Assessment of genetic relationships between cultivated arracacha (Arracacia xanthorrhiza Bancr.) and its wild close relatives in the area of domestication using microsatellite markers." Conservation Genetics 18, no. 6 (May 10, 2017): 1267–75. http://dx.doi.org/10.1007/s10592-017-0978-y.

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Dong, Peixin, Ying Xiong, Junming Yue, Sharon J. B. Hanley, Noriko Kobayashi, Yukiharu Todo, and Hidemichi Watari. "Exploring lncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment: Advances and Challenges." Cancers 11, no. 2 (February 16, 2019): 234. http://dx.doi.org/10.3390/cancers11020234.

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Recent studies have revealed both the promise and challenges of targeting long non-coding RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated or downregulated in ECs compared to normal tissues and their dysregulation has been linked to tumor grade, FIGO stage, the depth of myometrial invasion, lymph node metastasis and patient survival. Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-RoR) have been identified as upstream modulators or downstream effectors of major signaling pathways influencing EC metastasis, including the PTEN/PI3K/AKT/mTOR, RAS/RAF/MEK/ERK, WNT/β-catenin and p53 signaling pathways. TUG1 and TDRG1 stimulate the VEGF-A pathway. PCGEM1 is implicated in activating the JAK/STAT3 pathway. Here, we present an overview of the expression pattern, prognostic value, biological function of lncRNAs in EC cells and their roles within the tumor microenvironment, focusing on the influence of lncRNAs on established EC-relevant pathways. We also describe the emerging classification of EC subtypes based on their lncRNA signature and discuss the clinical implications of lncRNAs as valuable biomarkers for EC diagnosis and potential targets for EC treatment.

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Cai, Bingjie, Yunpeng Zheng, Shanshan Ma, Qu Xing, Xinxin Wang, Bo Yang, Guangwen Yin, and Fangxia Guan. "BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR-204." International Journal of Oncology 51, no. 6 (October 23, 2017): 1941–51. http://dx.doi.org/10.3892/ijo.2017.4173.

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Ide, S., V. A. Yuki, H. M. Takada, M. A. Delfino, H. Hojo, A. L. B. G. Peronti, C. R. Souza-Silva, H. Kuniyuki, S. C. S. Bueno, and W. Yamakawa. "SEMIAPHIS DAUCI (FABRICIUS) (INSECTA, HEMIPTERA, APHIDIDAE) – FORMAL RECORD OF OCCURRENCE ON ARRACACHA (ARRACACIA XANTHORRHIZA BANCR.) (APIACEAE) IN BRAZIL, MORPHOLOGICAL CHARACTERIZATION, DESCRIPTION OF DAMAGES AND ARTHROPODS ASSOCIATED TO THE CULTURE." Arquivos do Instituto Biológico 78, no. 1 (March 2011): 53–61. http://dx.doi.org/10.1590/1808-1657v78p0532011.

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ABSTRACT This paper reports formally the occurrence and describes the damages by Semiaphis dauci (Fabricius, 1775) (Insecta, Hemiptera, Aphididae, Aphidinae, Macrosiphini) on arracacha (Arracacia xanthorrhiza Bancr.) (Apiaceae) in Brazil. The infestation was initially noted on April/2002 at Núcleo de Produção de Mudas, Departamento de Sementes Mudas e Matrizes, Coordenadoria de Assistência Técnica Integral, Secretaria de Agricultura e Abastecimento, São Bento do Sapucaí, State of São Paulo. Posteriorly the occurrence was detected in other parts of the municipality of São Bento do Sapucaí such as Serrano, Paiol Grande and Cantagalo, being the incidence higher in localities at lower altitudes. The colonies, with large number of individuals, were settled on both sides of the leaves and also hidden under petiole, but with lower number of specimens. The adult plants were underdeveloped and the growing of aphid colonies induced the blossoming. In the seedlings the symptoms were severer with reduction in the development and death of plants. When the colonies were placed in the dorsal side of the leaves, there was a tendency to wrinkling and rolling to upper side that was used as shelter by the aphids. Morphological characterization, illustrations and notes on biology of .. dauci and a survey of the Arthropoda related with .. xanthorrhiza are also presented.

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López, Roberto. "Análisis financiero para la determinación de quiebra." Encuentro, no. 74 (July 12, 2006): 80–96. http://dx.doi.org/10.5377/encuentro.v0i74.3713.

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SE ESTUDIA LA PROBABILIDAD DE QUIEBRA DE EMPRESAS nicaragüenses en 1990, cuando surgió la banca privada tras acuerdos entre empresarios y el gobierno, que modernizaron las finanzas, pero presentaron riesgos empresariales. Se dieron restricciones legales, riesgos políticos y fragilidad de las instituciones financieras ante la banca internacional. Además, las fluctuaciones del tipo de cambio del córdoba originan cuatro riesgos: conversión, de transacciones, económico y operativo. Diferentes investigadores han desarrollado modelos de alertas financieras: J. Tobin, que desarrolló “Q de Tobin”; W. Beaver, para empresas manufactureras; M. Tamarí, un sistema de puntaje; y E. Altman desarrolló el modelo “Z de Altman”, que da un índice de baja, alta o altísima probabilidad de quiebra. Se aplicó este modelo a las empresas quebradas a fines de 2000: Banco Europeo de Centroamérica (BECA), Banco Nacional de Desarrollo (BANADES), Banco de Crédito Popular (BCP), Banco del Campo (BANCAMPO), y Banco Internacional (INTEBANK).

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Rochet, Appukuttan, Ma, Ashander, and Smith. "Expression of Long Non-Coding RNAs by Human Retinal Müller Glial Cells Infected with Clonal and Exotic Virulent Toxoplasma gondii." Non-Coding RNA 5, no. 4 (September 20, 2019): 48. http://dx.doi.org/10.3390/ncrna5040048.

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Retinal infection with Toxoplasma gondii—ocular toxoplasmosis—is a common cause of vision impairment worldwide. Pathology combines parasite-induced retinal cell death and reactive intraocular inflammation. Müller glial cells, which represent the supporting cell population of the retina, are relatively susceptible to infection with T. gondii. We investigated expression of long non-coding RNAs (lncRNAs) with immunologic regulatory activity in Müller cells infected with virulent T. gondii strains—GT1 (haplogroup 1, type I) and GPHT (haplogroup 6). We first confirmed expression of 33 lncRNA in primary cell isolates. MIO-M1 human retinal Müller cell monolayers were infected with T. gondii tachyzoites (multiplicity of infection = 5) and harvested at 4, 12, 24, and 36 h post-infection, with infection being tracked by the expression of parasite surface antigen 1 (SAG1). Significant fold-changes were observed for 31 lncRNAs at one or more time intervals. Similar changes between strains were measured for BANCR, CYTOR, FOXD3-AS1, GAS5, GSTT1-AS1, LINC-ROR, LUCAT1, MALAT1, MIR22HG, MIR143HG, PVT1, RMRP, SNHG15, and SOCS2-AS1. Changes differing between strains were measured for APTR, FIRRE, HOTAIR, HOXD-AS1, KCNQ1OT1, LINC00968, LINC01105, lnc-SGK1, MEG3, MHRT, MIAT, MIR17HG, MIR155HG, NEAT1, NeST, NRON, and PACER. Our findings suggest roles for lncRNAs in regulating retinal Müller cell immune responses to T. gondii, and encourage future studies on lncRNA as biomarkers and/or drug targets in ocular toxoplasmosis.

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Anaya Merchant, Luis Manuel. "Calles, fundador de instituciones bancarias: el Banco Mercantil y Agrícola de Sonora, 1917-1935." América Latina en la Historia Económica 27, no. 3 (August 5, 2020): e1083. http://dx.doi.org/10.18232/alhe.1083.

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Plutarco Elías Calles es reconocido como el creador de la banca central, precursor de la banca de desarrollo y un importante impulsor de la reorganización bancaria mexicana. Sin embargo, se desconoce su actividad como banquero privado. Esta investigación realiza un examen minucioso de fuentes originales para determinar las circunstancias que rodearon la fundación del Banco Mercantil y Agrícola de Sonora, la suerte de sus principales negocios y los recursos que empleó para subsistir casi dos décadas. Por supuesto, Calles fue su principal impulsor y accionista. Entre otras líneas analizadas están su formación empresarial, el desempeño de los gerentes y la influencia de la actividad económica regional sobre la del Banco, así como las redes político empresariales que alentó e incubó.

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Bellod, José Francisco. "El rescate del oligopolio bancario español." Revista de Economía Institucional 25, no. 48 (December 22, 2022): 75–103. http://dx.doi.org/10.18601/01245996.v25n48.06.

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Este escrito analiza las principales características de la reestructuración del sistema bancario español posterior a la crisis de 2008. El Banco de España –el brazo ejecutor de la política del Banco Central Europeo– y los gobiernos sucesivos acentuaron el carácter oligopólico de la banca española, pues sus medidas contribuyeron a limitar la competencia interna (eliminando las cajas de ahorros) y a socializar los costos del rescate bancario.

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Chen, Qi, Chengfang Xu, Zhonghao Sun, Jingjing Yang, Fan Chen, Zixiang Lin, Degui Lin, Yanyan Jiang, and Jiahao Lin. "Development of S4A–BSA–Au NPs for enhanced anti-tumor therapy of canine breast cancer." Nanoscale Advances 4, no. 7 (2022): 1808–14. http://dx.doi.org/10.1039/d1na00640a.

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Dehouck, Aurélie, Virginie Lafon, Nadia Sénéchal, Jean-Marie Froidefond, Rafael Almar, Bruno Castelle, and Nadège Martiny. "Evolution morphodynamique interannuelle du littoral sud de la Gironde." Revue Française de Photogrammétrie et de Télédétection, no. 197 (April 22, 2014): 31–42. http://dx.doi.org/10.52638/rfpt.2012.82.

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Une série d'images satellitaires Spot couvrant la période 1997-2009 (base Kalideos Littoral) est exploitée dans l'optique de caractériser l'évolution interannuelle du littoral sableux au sud du Bassin d'Arcachon. Un algorithme semi-analytique reposant sur les propriétés optiques des eaux et des petits fonds a été calibré et validé par des données in situ etappliqué à la série d'images pour produire des spatiocartes bathymétriques. Les observations indiquent une très forte connectivité entre les grands bancs de l'embouchure (Banc d'Arguin et Banc du Pineau) et les barres sous-marines des plages de par la relation « amont-aval » induite par la dérive littorale. Une séquence de 5 ans (1999-2004) a étéconstatée débutant par la dislocation du Banc d'Arguin, la migration d'énormes bancs de sable à travers la Passe Sud, conduisant à une alimentation massive du Banc du Pineau et des structures sous-marines des plages. En outre, la fréquence et l'incidence des houles de tempête contrôlent l'intensité et la direction des déplacements des barres sous-marines (migration cross-shore/longshore). Sur la période récente, cette mobilité se traduit notamment par la progression vers le sud de structures sableuses solidaires de la barre externe mais de plus faible profondeur, se déplaçant face à la plage de Biscarrosse actuellement suivie par des caméras vidéo.

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