Relevant bibliographies by topics / Bacterial antibiotics

Academic literature on the topic 'Bacterial antibiotics'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Bacterial antibiotics"

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Abedon, Stephen T. "Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy?" Antibiotics 8, no. 4 (October 11, 2019): 182. http://dx.doi.org/10.3390/antibiotics8040182.

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Bacteria can evolve resistance to antibiotics. Even without changing genetically, bacteria also can display tolerance to antibiotic treatments. Many antibiotics are also broadly acting, as can result in excessive modifications of body microbiomes. Particularly for antibiotics of last resort or in treating extremely ill patients, antibiotics furthermore can display excessive toxicities. Antibiotics nevertheless remain the standard of care for bacterial infections, and rightly so given their long track records of both antibacterial efficacy and infrequency of severe side effects. Antibiotics do not successfully cure all treated bacterial infections, however, thereby providing a utility to alternative antibacterial approaches. One such approach is the use of bacteriophages, the viruses of bacteria. This nearly 100-year-old bactericidal, anti-infection technology can be effective against antibiotic-resistant or -tolerant bacteria, including bacterial biofilms and persister cells. Ideally phages could be used in combination with standard antibiotics while retaining their anti-bacterial pharmacodynamic activity, this despite antibiotics interfering with aspects of bacterial metabolism that are also required for full phage infection activity. Here I examine the literature of pre-clinical phage-antibiotic combination treatments, with emphasis on antibiotic-susceptible bacterial targets. I review evidence of antibiotic interference with phage infection activity along with its converse: phage antibacterial functioning despite antibiotic presence.
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Hochvaldová, Lucie, Renata Večeřová, Milan Kolář, Robert Prucek, Libor Kvítek, Lubomír Lapčík, and Aleš Panáček. "Antibacterial nanomaterials: Upcoming hope to overcome antibiotic resistance crisis." Nanotechnology Reviews 11, no. 1 (January 1, 2022): 1115–42. http://dx.doi.org/10.1515/ntrev-2022-0059.

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Abstract When combined with nanomaterials, antibiotics show antibacterial activity against susceptible and resistant bacterial strains at significantly lower concentrations. Unfortunately, to date, no research study has examined the effect of the antibiotic mode of action and mechanism of bacterial resistance on the effectiveness of combined antibacterial treatment with nanomaterials. Therefore, in this review, we performed a thorough analysis and critical evaluation of previously published data related to the combined antibacterial effect of antibiotics with nanostructured materials with a targeted focus on relationships between antibiotic’s modes of action and bacterial resistance mechanisms for relevant nanomaterials and their impact on the resulting synergistic effects. Following thorough data analysis and critical discussion, we have discovered and are the first who present that antibiotic’s mode of action and bacterial resistance mechanism determine the final effectiveness of combined antibacterial treatment with nanomaterials. We therefore conclude that only certain combinations of nanomaterials with antibiotics can lead to the enhancement and restoration of the antibacterial effectiveness of antibiotics against certain resistant bacteria. Moreover, the recently occurring development of bacterial resistance towards nanomaterials is also discussed together with a possibility of how to prevent it. All discovered findings provide a new view and perspective on this issue helping to navigate further approaches to combat the antibiotic crisis.
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Chen, Qingquan, Tejas Dharmaraj, Pamela C. Cai, Elizabeth B. Burgener, Naomi L. Haddock, Andy J. Spakowitz, and Paul L. Bollyky. "Bacteriophage and Bacterial Susceptibility, Resistance, and Tolerance to Antibiotics." Pharmaceutics 14, no. 7 (July 7, 2022): 1425. http://dx.doi.org/10.3390/pharmaceutics14071425.

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Bacteriophages, viruses that infect and replicate within bacteria, impact bacterial responses to antibiotics in complex ways. Recent studies using lytic bacteriophages to treat bacterial infections (phage therapy) demonstrate that phages can promote susceptibility to chemical antibiotics and that phage/antibiotic synergy is possible. However, both lytic and lysogenic bacteriophages can contribute to antimicrobial resistance. In particular, some phages mediate the horizontal transfer of antibiotic resistance genes between bacteria via transduction and other mechanisms. In addition, chronic infection filamentous phages can promote antimicrobial tolerance, the ability of bacteria to persist in the face of antibiotics. In particular, filamentous phages serve as structural elements in bacterial biofilms and prevent the penetration of antibiotics. Over time, these contributions to antibiotic tolerance favor the selection of resistance clones. Here, we review recent insights into bacteriophage contributions to antibiotic susceptibility, resistance, and tolerance. We discuss the mechanisms involved in these effects and address their impact on bacterial fitness.
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Shifa Begum, Tofa Begum, Naziza Rahman, and Ruhul A. Khan. "A review on antibiotic resistance and way of combating antimicrobial resistance." GSC Biological and Pharmaceutical Sciences 14, no. 2 (February 28, 2021): 087–97. http://dx.doi.org/10.30574/gscbps.2021.14.2.0037.

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Antibiotics are widely used most effective medication since the twentieth century against bacterial infections (Tetanus, Strep Throat, Urinary Tract Infections, etc.) and thus save one’s life. Before 20th-century infectious disease played the main role in the death. Thus, antibiotics opened a revolutionary era in the field of medication. These cannot fight against viral infections. Antibiotics are also known as an antibacterial that kill or slow down bacterial growth and prohibit the bacteria to harm. Resistance comes as a curse with antibiotics that occurs when bacteria change in some way that reduces or eliminates the effectiveness of drugs, chemicals or other agents designed to cure or prevent infections. It is now a significant threat to public health that is affecting humans worldwide outside the environment of the hospital. When a bacterium once become resistant to antibiotic then the bacterial infections cannot be cured with that antibiotic. Thus, the emergence of antibiotic-resistance among the most important bacterial pathogens causing more harm. In this context, the classification of antibiotics, mode of action of antibiotics, and mechanism of resistance and the process of overcoming antibiotic resistance are discussed broadly.
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Ghai, Ishan. "A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance." Applied Sciences 13, no. 7 (March 27, 2023): 4238. http://dx.doi.org/10.3390/app13074238.

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Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment. This outer membrane contains many protein channels, also known as porins or nanopores, which mainly allow the influx of hydrophilic compounds, including antibiotics. One probable way bacteria may possibly develop antibiotic resistance is by reworking to reduce the inflow through these outer membrane porins or nanopores. The challenge now is to recognize and potentially comprehend the molecular basis of permeability via the bacterial outer membrane. To address this challenge, this assessment builds upon the author’s previous work to develop a comprehensive understanding of membrane porins and their crucial role in the influx of antibiotics and solutes. Furthermore, the work aspires to investigate the bacterial response to antibiotic membrane permeability and nurture discussion toward further exploration of the physicochemical parameters governing the translocation/transport of antibiotics through bacterial membrane porins. By augmenting our understanding of these mechanisms, we may devise novel approaches to mitigate antibiotic resistance in Gram-negative bacteria.
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Harpaz, Dorin, Robert S. Marks, Ariel Kushmaro, and Evgeni Eltzov. "Environmental pollutants induce noninherited antibiotic resistance to polymyxin B in Escherichia coli." Future Microbiology 15, no. 17 (November 2020): 1631–43. http://dx.doi.org/10.2217/fmb-2020-0172.

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Aim: The mechanisms behind antibiotic resistance by bacteria are important to create alternative molecules. Objective: This study focuses on the impact of environmental pollutants on bacterial resistance to antibiotics. Materials & methods: The effect of various environmental pollutants on noninherited bacterial resistance to antibiotics was examined. Results: The tolerance to the polymyxin-B antibiotic was shown to be conferred to Escherichia coli, by pretreatment with subinhibitory concentrations of environmental toxicants. The cell survival to a sublethal dosage of antibiotics was tested. Exposure to low concentrations of toxic compounds (500 ppb copper, 2% [v/v] ethanol or 0.5 μg/ml trimethoprim) stimulated the bacterial heat shock systems and led to increased tolerance to polymyxin B. Conclusion: Environmental pollutants induce a temporary bacterial noninheritable resistance to antibiotic.
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Syahputra, Ryan Ravi Is, Dini Agustina, and Septa Surya Wahyudi. "The Sensitivity Pattern of Bacteria Against Antibiotics in Urinary Tract Infection Patients at RSD DR. Soebandi Jember." Journal of Agromedicine and Medical Sciences 4, no. 3 (October 11, 2018): 171. http://dx.doi.org/10.19184/ams.v4i3.6786.

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Urinary tract infection (UTI) was infection by microorganisms in the urinary tract. Treatment of UTI required supportive therapy and adequate antibiotics. Antibiotic resistance was the solution in the treatment of UTI, so it is important to assess the factors of bacterial resistance and strategies to control the incidence of resistance by choosing antibiotics in accordance with the pattern of sensitivity of germs obtained. This study aimed to determine the pattern of bacterial susceptibility to antibiotics in patients with UTI in RSD dr. Soebandi Jember. This research used descriptive research design by taking secondary data that was medical record data of urine culture examination and sensitivity test to antibiotics in UTI patients who have been diagnosed in inpatient and outpatient room RSD dr. Soebandi Jember between the period January 1, 2014 until November 30, 2017. The results of this study obtained 57 samples of urine positive bacteria, which found 18 types of bacteria that caused UTI. Of the 18 types of bacteria, there were 16 Gram negative bacteria and 2 Gram positive bacteria. Five bacteria divided among others E. coli on 24 samples, K. ornithinolytica on 5 samples, K. pneumoniae on 4 samples, B. cepacia on 4 samples, and E. cloacae on 3 samples. The results of bacterial sensitivity to antibiotic pattern showed the highest sensitivity level ie amikacin, fosfomicin, netilmicin, gentamicin, and nitrofurantoin. While the results of patterns of bacterial resistance to antibiotics based on hormonal levels of cephalotin, cephazolin, ampicillin, sulphametoxazole, and trimetoprim. Keywords: Urinary Tract Infection (UTI), Bacterial sensitivity, Antibiotics
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J, Prarthana. "Biological and Computational Approach to Modify Bacterial Size and Reduce its Antibiotic Consumption Targeting Mreb Bacterial Cytoskeletal Protein." Bioscience Biotechnology Research Communications 15, no. 1 (March 25, 2022): 70–76. http://dx.doi.org/10.21786/bbrc/15.1.11.

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Amongst the cytoskeletal proteins of bacteria, MreB is known to have very crucial role in modulating shape of the bacteria. Present study involves the use of biocide (A-22) which minimizes the bacterial size augmenting with minimal antibiotic consumption. Intended experiment is designed to be carried out on selected pure strains of gram-positive and gram-negative bacteria namely Lactobacillus rhamnosous ATCC 7469 and Pseudomonas aeruginosa ATCC 27853 respectively. The pure strains are exposed to biocide and changes in the shape is recorded by means of Foldscope (Origami based paper microscope, Prakash Labs) and in-vivo assessment done using antibiotic sensitivity assays with different antibiotics.The novel biocide specifically targeting bacterial cytoskeletal protein, that determines rod shape among bacterial population. The said compound is also experimented as combinational drug along with conventional antibiotics to reduce antibiotic dose needed to kill and to overcome antibiotic resistance. The A-22has reduced nearly 60-70% antibiotic usage. In Pseudomonas aeruginosa ATCC 27853 when tested for MIC using A-22 and different antibiotics, it was found that 0.5 µg/ml of ampicillin, 1 µg/ml of streptomycin and 5 µg/ml erythromycin were effective in curtailing bacteria against conventional antibiotic concentrations ampicillin 128 µg/ml streptomycin 32 µg/ml, erythromycin 64 µg/ml. Compared to doses of antibiotics required to kill bacteria, the combinational drug of biocide and antibiotic have shown promising effects in killing bacteria at very less concentration, this can useful for treating most diseases caused by antimicrobial resistance bacterial populations.
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Diallo, Kevin, and Alain Dublanchet. "Benefits of Combined Phage–Antibiotic Therapy for the Control of Antibiotic-Resistant Bacteria: A Literature Review." Antibiotics 11, no. 7 (June 22, 2022): 839. http://dx.doi.org/10.3390/antibiotics11070839.

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With the increase in bacterial resistance to antibiotics, more and more therapeutic failures are being reported worldwide. The market for antibiotics is now broken due to the high cost of developing new molecules. A promising solution to bacterial resistance is combined phage–antibiotic therapy, a century-old method that can potentiate existing antibiotics by prolonging or even restoring their activity against specific bacteria. The aim of this literature review was to provide an overview of different phage–antibiotic combinations and to describe the possible mechanisms of phage–antibiotic synergy.
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Liu, Yuan, Ruichao Li, Xia Xiao, and Zhiqiang Wang. "Molecules that Inhibit Bacterial Resistance Enzymes." Molecules 24, no. 1 (December 22, 2018): 43. http://dx.doi.org/10.3390/molecules24010043.

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Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed.
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Dissertations / Theses on the topic "Bacterial antibiotics"

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Messer, Janet Mariam. "Bacterial resistance ot glycopeptide antibiotics." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239488.

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Leszcynski, Robert A. "Determination of the Relationship Between Bacterial Coculturing, Antibiotic Resistance and Bacterial Growth." University of Dayton / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1591787505690696.

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Lovmar, Martin. "Macrolide Antibiotics in Bacterial Protein Synthesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6009.

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Lawrence, Christopher C. "Studies on bacterial proline 4-hydroxylase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358610.

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Davidson, Seana Kelyn. "Biology of the bryostatins in the marine bryozoan Bugula neritina : symbiosis, cryptic speciation and chemical defense /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p3035405.

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Verderosa, Anthony Daniel. "Nitroxide functionalised antibiotics for the eradication of bacterial biofilms." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/135167/1/Anthony_Verderosa_Thesis.pdf.

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Bacterial biofilms are a leading cause of life-threatening and device-related infections worldwide. Biofilm related infections are notoriously difficult to treat as they are highly tolerant to conventional antibiotics. This project has designed and synthesised a new class of antibiotics to circumvent biofilm tolerance and shown that the prepared compounds could eradicate several medically important pathogens (P. aeruginosa, E. coli, and S. aureus). Importantly, as these compounds are hybrids of drugs that are already used clinically as stand-alone therapies, they demonstrate great potential to be translated into therapies in the near future.
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Riscado, Andreia Catarina Morgado. "Estudo das (multi)resistências bacterianas em clínica de animais de companhia." Master's thesis, Universidade de Évora, 2020. http://hdl.handle.net/10174/27834.

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O presente relatório de estágio pretende espelhar o trabalho desenvolvido, as competências adquiridas e as aprendizagens consolidadas durante a realização do estágio curricular na Clínica Veterinária - Clilegre, entre outubro de 2018 e janeiro de 2019. O documento é composto por duas partes: na primeira descrevem-se as atividades desenvolvidas e a casuística acompanhada; na segunda inclui-se uma monografia sobre a problemática das resistências aos antimicrobianos, com apresentação e discussão dos casos clínicos em que foi realizada colheita bacteriológica e teste de sensibilidade aos antibióticos em animais de companhia. A resistência bacteriana é um fenómeno natural que, aliado ao uso incorreto e excessivo de antimicrobianos, tem favorecido a seleção de estirpes resistentes, tornandose num grave problema de saúde pública mundial. Considerando a crescente proximidade entre animais de companhia e o Homem, torna-se fundamental estudar o problema da resistência aos antimicrobianos, sensibilizando profissionais de saúde para o uso adequado destes fármacos; Abstract: Study of (multi)resistant bacteria in companion animals clinics This internship report intends to mirror the work developed, the skills acquired and knowledge consolidation during the curricular internship at the Clilegre Veterinary Clinic, from october 2018 to january 2019. The document consists of two parts: the first part describes the activities developed and the casuistic followed; the second includes a monography about antimicrobial resistance, with the presentation and discussion of clinical cases in which bacteriological isolation and antibiotic susceptibility testing were performed in companion animals. Bacterial resistance is a natural phenomenon that, combined with the incorrect and excessive use of antibiotics, has favoured the selection of resistant strains, becoming a serious public health problem worldwide. Considering the growing proximity between companion animals and humans, it is essential to study the problem of antibiotic resistance and raising awareness to health professionals to the proper use of these drugs.
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Perez, Fernandez Déborah. "Aminoglycoside antibiotics to selectively target bacterial 16S ribosomal RNA /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17284.

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Batten, Laura Elizabeth. "Bacterial kinases as potential targets for broad-spectrum antibiotics." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/360883/.

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Polyphosphate biosynthesis and the stringent response play an important role in the virulence of pathogenic bacteria. Our objective is to validate these pathways as an antimicrobial target and to identify inhibitors of the key enzymes polyphosphate kinase (PPK), (p)ppGpp synthetase I (RelA) and (p)ppGpp synthetase/hydrolase II (SpoT). The role of polyphosphate and (p)ppGpp metabolism in Francisella virulence has been explored with deletion mutants. These exhibited defects for intracellular growth in macrophages and were attenuated in mice, indicating a key role for the FtPPK, FtRelA and FtSpoT in the virulence of Francisella. The development of three in vitro activity assays will enable the discovery of PPK inhibitors. Ion-pairing HPLC analysis has been used to measure substrate kinetics, providing evidence that FtPPK belongs to the PPK2 superfamily with little preference between substrates (KM: ADP - 369 μM; GDP - 624 μM) as displayed by other PPK2 enzymes. 31P NMR spectroscopy has been used to monitor the overall time course of the PPK reaction. To facilitate high-throughput screening, a coupled luminescence based activity assay has been developed in a 96-well plate format. These assays can also be applied to the discovery of inhibitors for FtRelA and FtSpoT. Understanding the structural basis of inhibitor action requires a crystal structure of the target enzyme. For FtPPK, a crystallisation screen has identified conditions for obtaining suitable crystals and data has been collected to 2.1 Å resolution. Future studies will use the high throughput assay to identify PPK inhibitors; NMR and HPLC assays to characterise the mode of action and crystal structures of PPK:inhibitor complexes will identify the precise molecular interactions.
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Powell, James Patrick. "Antibiotic Diversity and Bacterial Resistance." Available to users online at:, 2007. http://hdl.handle.net/10156/1303.

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Books on the topic "Bacterial antibiotics"

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Antibiotics and antibiotic resistance. Hoboken, N.J: Wiley, 2011.

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Antibiotics. Detroit: Greenhaven Press, 2011.

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Conan, MacDougall, ed. Antibiotics, simplified. Sudbury, Mass: Jones and Bartlett Publishers, 2009.

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Morente, Elena Ortega, and Antonio Espinosa Ubeda. Antibiotics 2005. Kerala, India: Research Signpost, 2005.

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Buhner, Stephen Harrod. Herbal antibiotics. 2nd ed. North Adams, MA: Storey Pub., 2012.

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Conan, MacDougall, ed. Antibiotics simplified. 3rd ed. Burlington, MA: Jones & Bartlett Learning, 2014.

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Hays, Virgil W. Antibiotics for animals: The antibiotic-resistance issue. Ames, Iowa: Council for Agricultural Science and Technology, 1989.

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Viruses vs. superbugs: A solution to the antibiotics crisis? London: Macmillan, 2006.

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The antibiotic paradox: How the misuse of antibiotics destroys their curative power. 2nd ed. Cambridge, MA: Perseus Pub., 2002.

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Reese, Richard E. Handbook of antibiotics. 2nd ed. Boston: Little, Brown, 1993.

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Book chapters on the topic "Bacterial antibiotics"

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Brodolin, Konstantin. "Antibiotics Targeting Bacterial RNA Polymerase." In Antibiotics, 299–321. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527659685.ch12.

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Jindal, Bhavya, Anusri Bhattacharya, and Dulal Panda. "Inhibitors of Bacterial Cell Partitioning." In Antibiotics, 151–82. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527659685.ch7.

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Wilson, Daniel. "Peptidyltransferase Inhibitors of the Bacterial Ribosome." In Antibiotics, 471–90. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527659685.ch20.

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Maresso, Anthony William. "Antibiotics … and Their Destruction." In Bacterial Virulence, 195–212. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-20464-8_16.

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Fabbretti, Attilio, and Anna Maria Giuliodori. "Inhibitors of Bacterial Elongation Factor EF-Tu." In Antibiotics, 437–52. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527659685.ch18.

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Safari-Sinegani, Ali-Akbar, Mehdi Rashtbari, Nayereh Younessi, and Babak Mashkoori. "Antibiotics and Microbial Antibiotic Resistance in Soil." In Bacterial Adaptation to Co-resistance, 211–32. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8503-2_11.

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Chan, Pan F., Jianzhong Huang, Benjamin D. Bax, and Michael N. Gwynn. "Recent Developments in Inhibitors of Bacterial Type IIA Topoisomerases." In Antibiotics, 263–97. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527659685.ch11.

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Valade, Eric, Anne Davin-Regli, Jean-Michel Bolla, and Jean-Marie Pagès. "Bacterial Membrane, a Key for Controlling Drug Influx and Efflux." In Antibiotics, 217–40. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527659685.ch9.

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Datta, Naomi. "Bacterial Resistance to Antibiotics." In Ciba Foundation Symposium 102 - Origins and Development of Adaptation, 204–18. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720837.ch13.

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Kumar, Anil, and Nikita Chordia. "Bacterial Resistance Against Antibiotics." In Drug Resistance in Bacteria, Fungi, Malaria, and Cancer, 171–92. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-48683-3_7.

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Conference papers on the topic "Bacterial antibiotics"

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Kumalasari, Yeni Indra, Agung Dian Kharisma, and Sri Yuwantiningsih. "Potential of Karimunjawa Island’s Plants as Antibiotic-Producing Endophytic Bacteria Sources." In The 2nd International Conference on Technology for Sustainable Development. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-kv25ou.

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Endophytic bacteria have a great potential to be applied as biofertilizers and biopesticides, but their information as a source of antibiotics still needs to be developed and explored. The aim of this study was to investigate the potential sources of antibiotics in endophytic bacteria isolated from the stems of Setigi, Wahong, Bongko, Kalimosodo, Dewandaru, and Legundi plants on Karimunjawa Island. Molecular approaches were performed to isolate, characterize, and identify bacterial endophytes as potential antibiotic sources by plate assay and 16S rRNA gene sequence analysis. Dewandaru isolate was identified as gram-negative bacteria, whereas; gram-positive bacteria were detected in other isolates. Moreover, Setigi and Dewandaru isolates showed the highest level to inhibit the growth of Fusarium sp and displayed 99% similarity with antibiotic-producing bacteria, namely Bacillus pumilus and Bacillus cereus, respectively. These results indicate the possibility of antibiotic activities by Setigi and Dewandaru isolated. Therefore, it is assumed that both Setigi and Dewandaru isolates potentially appeared as new antibiotics sources from local plants. This study provides novel insight into the future production of novel antibiotics derived from plant-associated endophytic bacterial as a strategy for increasing the application of natural compounds to control plant diseases in agriculture.
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Popova, O. S. "Bacterial enzyme systems as a cause for antibiotic affinity in bacteria." In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2023-11-53-56.

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The success of the use of antibiotic drugs is not in doubt. Despite the prepared base of regulatory documents, the use of antibiotics has a number of difficulties in their implementation and use in practice
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Khair, Nedaa Kamalalden. "Activity of Antibiotic Producing Bacteria Isolated from Rhizosphere Soil Region of Different Medicinal Plants." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0093.

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The rhizosphere soil of medicinal plants is rich in microorganisms that develop antibiotics as natural mechanism of protection against other microbes that live in their vicinity. The present study aims to explore the production of antibacterial agents from rhizosphere soil bacteria of 11 medicinal plants and determine their activity against Gram-negative (Pseudomonas aeruginosa, Escherichia coli) and Gram-positive (Bacillus cereus, Staphylococcus aureus) bacteria. Soil samples were collected and used to isolate antibiotic producing bacteria (APB). Those isolates (108) were first tested using Cross-streak method against test bacteria. Then, isolates that showed a positive antibacterial effect (12) were tested by antibiotic susceptibility test (AST) of their cell free supernatant (CFS) and their extracellular and intracellular secondary metabolites extraction which gave positive results. Staphylococcus aureus found to be the most sensitive test bacteria with inhibitory zones ranging from 13.5 - 19 mm. Moreover, combinatorial effect of isolates CFS with two organic acids (3% Acetic acid and 0.4 mg/ml Acetylsalicylic acid), two commercial antibiotics (0.016 mg/ml Augmentin and 0.128 mg/ml Doxycycline), and two pure antibiotics (10 mcg/disk Penicillin and 25mcg/disk Carbenicillin) was in vitro evaluated using AST. The combinations of CFS-carbenicillin showed a marked synergistic activity against all test bacteria. The presence of possible antibacterial agents as acetic acid, lactic acid and citric acid in CFS of APB was confirmed by HPLC analysis. Ultimately, in vitro antibacterial study for rhizosphere soil bacteria in this work suggests the possibility of using these bacterial metabolites in clinical infections caused by selected test bacteria, especially when they combine with antibiotics or organic acids.
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Khudadad, Hanan, and Lukman Thalib. "Antibiotics Prescription Patterns in Primary Health Care in Qatar – A Population based study from 2017 to 2018." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0169.

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Background: Antibiotics are antimicrobial drugs used in the treatment and prevention of bacterial infections. They played a pivotal role in achieving major advances in medicine and surgery (1). Yet, due to increased and inappropriate use of antibiotics, antibiotic resistance (AR) has become a growing public health problem. Information on antibiotic prescription patterns are vital in developing a constructive approach to deal with growing antibiotic resistance (2). The study aims to describe the population based antibiotic prescriptions among patients attending primary care centers in Qatar. Methodology: A population based observational study of all medications prescribed in the all Primary Health Care Centers during the period of 2017-2018 in Qatar. Records with all medication prescriptions were extracted and linked to medical diagnosis. Antibiotics prescriptions records were compared to non- antibiotics records using logistic regression model in identifying the potential predictors for antibiotic prescriptions. Results: A total of 11,069,439 medication prescriptions given over a period of two-years, we found about 12.1% (n= 726,667) antibiotics prescriptions were antibiotics, and 65% of antibiotics are prescribed and received by the patients at the first visits. Paracetamol (22.3%) was the first highest medication prescribed followed by antibiotics (12.1 %) and vitamin D2 (10.2 %). More than half of all antibiotics prescribed during the period of January 2017 to December 2018 were Penicillin (56.9%). We found that half of the antibiotics (49.3 %) have been prescribed for the respiratory system comparing to the other body system. We found that males were 29% more likely be given an antibiotic compared to females (OR=1.29, 95% CI= 1.24- 1.33). Implications: The study provides a baseline data to enable PHCC management to design effective intervention program to address the problem of antibiotics resistance. Furthermore, it will help the policymakers to comprehend the size of the issue and develop a system to manage the antibiotics therapy. Conclusion: Antibiotics was the second highest medication prescribed in the Primary Health Care Centers in Qatar after paracetamol and most of the patients received it at the first visit. Most of the prescriptions in Primary Health Care Centers in Qatar were for the respiratory system, and Penicillin was the highest class prescribed. Male visitors were prescribed antibiotics more than female visitors.
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Rodrigues, Francisco, Raquel Teixeira, and Patricia Coelho. "Antibiotic consumption in Portugal - An overview." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-225.

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Infections caused by opportunistic bacteria resistant to multiple antibiotics continue to be a major challenge in the hospital environment. Growing bacterial resistance results in compromising the success of immunosuppressive therapies and surgical interventions (transplantation), which associated with a high risk of bacterial infections during the procedure and post-operatively often culminate in the death of the patient.
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Soares, Jennifer M., Vanderlei S. Bagnato, and Kate C. Blanco. "Synergistic enhancement effects of antibiotic combination with photodynamic inactivation." In Latin America Optics and Photonics Conference. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/laop.2022.w4a.29.

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Antimicrobial resistance is one of the most severe threats to global public health in this century. Photodynamic Inactivation (PDI) is an alternative to antibiotic therapy, a standard treatment for infections because the combination of a photosensitizer with light leads to the production of reactive oxygen species that promote eliminating undesirable cells without bacterial selection and with few side effects for the patient. This work investigates whether PDI can restore bacterial sensitivity to antibiotics. PDI protocols using curcumin and light at 450 nm are applied at regular intervals and new values of minimum inhibitory concentration of antibiotics are obtained. As a result, we observed that PDI treatments can decrease MIC. Thus, the combination of both antimicrobial therapies may result in synergistic effects.
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Almeida, Hélida Maravilha Dantas e. Sousa, Lara Bianca Soares Brandão, Thamara Rodrigues de Melo, and Sávio Benvindo Ferreira. "Anti-Bacterial Perspective of Non-Antibiotic Drugs." In The 2nd International Electronic Conference on Antibiotics—Drugs for Superbugs: Antibiotic Discovery, Modes of Action and Mechanisms of Resistance. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/eca2022-12701.

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Breitrück, Anne, Bernd Kreikemeyer, and K. M. Henkel. "Antipathogenic Coatings for Antibiotics Reduction in Broiler Farming." In ITSC 2023. ASM International, 2023. http://dx.doi.org/10.31399/asm.cp.itsc2023p0717.

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Abstract In the current work, typical thermal-sprayed copper-based alloys are investigated to reduce the spread of pathogenic germs in broiler farming. Compressed air and nitrogen are used as process gas, while the coating torches and the alloys were varied. The results demonstrate a significant reduction in pathogenic load due to the coatings. This accounts especially for the bacterial strain E.ceocurm, which is the predominant bacteria in broiler farming. Further investigations regarded the microstructure and the electrical conductivity of the coatings.
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Lutphy Ali, Noor, Mustafa D. Younus, Omar F. Bahjat, Lina Sordash Hassan, Mohamad Hawar Rahman, Kawa Kamal Kareem, Darya Emad, and Hataw Ali. "Identification of Pharyngitis Bacteria in Patients with Sore Throat Features in Rizgary Teaching Hospital and Overuse of Antibiotics." In 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022). Cihan University, 2022. http://dx.doi.org/10.24086/biohs2022/paper.745.

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This research is designed to study sore throat (pharyngitis) and its causes, which is considered to be one of the serious health problems that affect many individuals annually. The research included an infected study status of 81 cases suspected of pharyngitis attending Rzgary Hospital department of ENT, in Erbil city. Infection was diagnosed by culturing the throat swab and collecting data about individual gender, age, occupation and residency. Also, this study deals with acute and chronic pain of sore throat (pharyngitis) and describes their causes. As well as the diagnosis was also achieved. Streptococcus pneumonia, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus sp., were isolated from the pharyngitis patients. The antibiotic susceptibility test was carried on the isolated bacteria using different types of antibiotics such as Ampicillin, Penicillin, Streptomycin, Ceftriaxone and Cefotaxime. The results indicated that most of the bacteria were resistant to the antibiotics. The highest sensitivity of pathogenic bacterial species was found towards streptomycin, while Ampicillin and Penicillin had the highest resistance; hence antimicrobial treatment should be recommended only after culturing and sensitivity testing. This would aid in the appropriate treatment, discourage the indiscriminate use of antibiotics, and avoid further development of drug resistance. It has been found that males are more vulnerable to getting pharyngitis than females. Age has a significant influence on increasing or decreasing the number of infected people. Also, the individuals living in Erbil city are more prone to be infected than those in the villages.
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M.Y. AL-TAEE, Sura, Amina G.O. AL-ANI, and Alaa Younis MAHDY. "16s rRNA SEQUENCING FOR IDENTIFICATION BACTERIA FROM FACE MASK OF STUDENTS IN MOSUL UNIVERSITY." In V. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress5-6.

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The use of masks has increased recently under the conditions of the Covid-19 pandemic as a prevention from the Covid-19, the research dealt with the study of bacterial contamination of masks from the surrounding environment, where in addition to the ability of masks to prevent the spread of viruses and bacteria, they are likely to be a source of bacterial contamination from the face, hands and air. 45 samples of face masks were collected from students of Mosul University in Iraq and the face mask was printed directly on Nutrient agar for 5 sec. Sixty isolates were obtained purely ,Gram-positive bacteria were predominated after smearing the pure isolates and staining them with Gram stain. Gram-positive isolates were grown on mannitol salt agar, which showed that they were not capable of fermenting mannitol sugar, oxidase and catalase assay was also performed, which gave a positive result for catalase and negative for oxidase .Three isolates were selected for molecular diagnosis by 16S rRNA. According to the 16S rRNA gene sequencing, three isolates were designated as:- Staphylococcus equorumand two isolates for Staphylococcus saprophyticus.The isolates showed sensitivity to Amikacin,Vancomycin,Chloramphenicol and Erythromycin antibiotics except for the antibiotic ofloxacin, Staphylococcus equorum and one isolate for Staphylococcus saprophyticus were intermediate to it
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Reports on the topic "Bacterial antibiotics"

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Peñaloza, Blanca. Which interventions can improve antibiotic prescription in ambulatory setting? SUPPORT, 2011. http://dx.doi.org/10.30846/11080608.

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The unnecessary use of antibiotics in the ambulatory setting can produce increased antimicrobial resistance among bacterial pathogens. This increasing prevalence of antibiotic resistance has led to the use of more expensive and broad spectrum antibiotics, contributing to increasing health care costs. Numerous strategies to reduce inappropriate use of antibiotics have been implemented by investigators and organizations at the clinician, patient and organization level.
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Aleksova, Michaella. Azoxystrobin Impact on a Selection of Soil Bacterial Resistance to Amynoglicoside Antibiotics. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, October 2019. http://dx.doi.org/10.7546/crabs.2019.10.08.

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AlBakri, Aref, Auswaf Ahsan, Manoj Vengal, KR Ashir, Abdul Majeed, and Hanan Siddiq. Antibiotic Prophylaxis before Invasive Dental Procedures for Patients at High-Risk of Infective Endocarditis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0011.

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Review question / Objective: The aim of the present systematic review and meta-analysis is to determine whether there is a genuine clinical need for Antibiotic Prophylaxis(AP) for the prevention of Infective Endocarditis(IE) in high-risk individuals (particularly those with demonstrable structural heart diseases or valve surgery) undergoing invasive dental procedures. Information sources: PubMed, Science Direct, British Dental Journal and Cochrane Register of Controlled Trials. Search terms used included various combinations of the following subject headings and title or abstract keywords – prophylactic antibiotics, antibiotic prophylaxis, antimicrobial, dentist, extraction, implant, infective endocarditis, or bacterial endocarditis.
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Bezerra, Alexandre Sacchetti, Flavia Altheman Loureiro, Carla Maria Pasquareli Vazquez, Afonso Cesar Polimanti, and Rafi Felicio Bauab Dauar. Empiric Treatment of Foot Infection in Patients with Severe Diabetes. Science Repository, December 2021. http://dx.doi.org/10.31487/j.jicoa.2021.04.04.

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Background: Despite being treated with antibiotics of broad spectrum recommended by International Consensus, severe diabetic patients with lower limb infection do not present a positive clinical evolution during empirical treatment. This study’s bacterial profile was analysed and compared with other worldwide hospital centers. Objective: To confirm the need of an individualized empirical treatment for severe diabetic patients with foot infection. Methods: Retrospective analysis of cultures and antibiograms of severe diabetic patients admitted by foot infection. Results: The results were consistent with the socioeconomic realities of developing countries. Gram-negative bacteria (52,11%) were present in most bone cultures. Results presented a high incidence of Enterococcus faecalis in both gram-positive (21,2%) and polymicrobial (34,7%) samples. Bacterial resistance with the use of ordinary antibiotics in the statistical analysis was high. Conclusion: The community infections should undergo broad spectrum empirical therapy combining amikacin (80,43%) or meropenem (72,00%) with gram-negative and vancomycin (100%) or teicoplanin (90,00%) or linezolid (74,19%) with gram-positive.
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Rosa-Mangeret, Flavia, Otis Olela, Francisca Barcos-Munoz, Noemie Wagner, Olivier Duperrex, Marc Dupuis, and Riccardo E. Pfister. Drug Resistant Bacterial Neonatal Early Onset Sepsis in Africa: A 20 year- prevalence review and metanalysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0112.

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Review question / Objective: What is the prevalence of drug-resistant pathogens associated with neonatal Early Onset Sepsis (NEOS) in the African continent and their likelihood of resistance to commonly used antibiotics in the NEOS, and what is the trend through time? Condition being studied: There is no consensus on the definition of neonatal sepsis. Two main categories of neonatal sepsis are widely accepted: early-onset sepsis (EOS) defined as occurring in the first 72 hours of life, hence representing perinatal vertical infection; and late-onset sepsis (LOS), which occurs between 72 hours to 28 days and can be hospital or community-acquired. Information sources: Pubmed, EMBASE, Web of Science. All authors from papers with missing information were contacted before article exclusion.
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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed at detecting BCAs and associated biologically-active compounds, which included: (A) isolation of multidrug-resistant desert soil bacteria and root-associated bacteria from medicinal plants; (B) invitro screening of bacterial isolates against known plant, animal and human pathogens; (C) nextgeneration sequencing of isolates that displayed antagonistic activity against at least one of the model pathogens and (D) in-planta screening of promising BCAs in a model bean-Sclerotiumrolfsii system. The BCA genome data were examined for presence of: i) secondary metabolite encoding genes potentially linked to the anti-pathogenic activity of the isolates; and ii) rhizosphere competence-associated genes, associated with the capacity of microorganisms to successfully inhabit plant roots, and a prerequisite for the success of a soil amended BCA. Altogether, 56 phylogenetically-diverse isolates with bioactivity against bacterial, oomycete and fungal plant pathogens were identified. These strains were sent to Auburn University where bioassays against a panel of animal and human pathogens (including multi-drug resistant pathogenic strains such as A. baumannii 3806) were conducted. Nineteen isolates that showed substantial antagonistic activity against at least one of the screened pathogens were sequenced, assembled and subjected to bioinformatics analyses aimed at identifying secondary metabolite-encoding and rhizosphere competence-associated genes. The genome size of the bacteria ranged from 3.77 to 9.85 Mbp. All of the genomes were characterized by a plethora of secondary metabolite encoding genes including non-ribosomal peptide synthase, polyketidesynthases, lantipeptides, bacteriocins, terpenes and siderophores. While some of these genes were highly similar to documented genes, many were unique and therefore may encode for novel antagonistic compounds. Comparative genomic analysis of root-associated isolates with similar strains not isolated from root environments revealed genes encoding for several rhizospherecompetence- associated traits including urea utilization, chitin degradation, plant cell polymerdegradation, biofilm formation, mechanisms for iron, phosphorus and sulfur acquisition and antibiotic resistance. Our labs are currently writing a continuation of this feasibility study that proposes a unique pipeline for the detection of BCAs and biopesticides that can be used against phytopathogens. It will combine i) metabolomic screening of strains from our collection that contain unique secondary metabolite-encoding genes, in order to isolate novel antimicrobial compounds; ii) model plant-based experiments to assess the antagonistic capacities of selected BCAs toward selected phytopathogens; and iii) an innovative next-generation-sequencing based method to monitor the relative abundance and distribution of selected BCAs in field experiments in order to assess their persistence in natural agro-environments. We believe that this integrated approach will enable development of novel strains and compounds that can be used in large-scale operations.
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Haynes, Dr Edward, Chris Conyers, Dr Marc Kennedy, Roy Macarthur, Sam McGreig, and Dr John Walshaw. What is the Burden of Antimicrobial Resistance Genes in Selected Ready-to-Eat Foods? Food Standards Agency, November 2021. http://dx.doi.org/10.46756/sci.fsa.bsv485.

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This study was designed to get a broad estimate of the presence and the types of antimicrobial resistance genes across 52 simple ready-to-eat foods. It was also carried out to understand the benefits and drawbacks of using metagenomic sequencing, a fairly new technology, to study AMR genes. An antimicrobial is any substance that kills or inhibits the growth of microorganisms. It includes antibiotics which are used to treat bacterial infections in both humans and animals. Given the relevant selective pressures, the bacteria itself can change and find ways to survive the effects of an antimicrobials. This results in the bacteria becoming resistant to the ‘killing’ effects of antimicrobials and is known as ‘antimicrobial resistance’. The more we use antimicrobials and antibiotics and the way that we use them can increase the chance that bacteria will become resistant to antimicrobials. This is important as it can lead to infections that become more difficult to treat with drugs and poses a risk to the public health. T Addressing AMR is a national strategic priority for the UK Government which has led to the development of a new 20-year Vision for AMR and the 5-year National Action Plan (NAP), which runs until 2024. The NAP lays out how the UK will address the AMR challenge and takes a ‘One-Health’ approach which spans people, animals, agriculture, food and the environment. The NAP includes a specific section on the importance of better food safety to limit the contamination of foods and spread of AMR. This section emphasises the need to strengthen the evidence base for AMR and food safety through research, surveillance and promoting good practice across the food chain. The FSA is playing its part by continuing to fill evidence gaps on the role that food plays in AMR through the commissioning of research and surveillance. We are also promoting and improving UK food hygiene (‘4Cs’ messages) across the food chain that will help reduce exposure to AMR bacteria.
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Ciapponi, Agustín. What is the effectiveness of interventions to improve antibiotic prescribing practices for hospital inpatients? SUPPORT, 2016. http://dx.doi.org/10.30846/1610132.

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In-hospital infections caused by antibiotic-resistant bacteria and Clostridium difficile are associated with higher rates of death, illness and prolonged hospital stay which is a serious problem for patients and healthcare systems. These infections occur because antibiotics are used too often and incorrectly.
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Belkin, Shimshon, Sylvia Daunert, and Mona Wells. Whole-Cell Biosensor Panel for Agricultural Endocrine Disruptors. United States Department of Agriculture, December 2010. http://dx.doi.org/10.32747/2010.7696542.bard.

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Objectives: The overall objective as defined in the approved proposal was the development of a whole-cell sensor panel for the detection of endocrine disruption activities of agriculturally relevant chemicals. To achieve this goal several specific objectives were outlined: (a) The development of new genetically engineered wholecell sensor strains; (b) the combination of multiple strains into a single sensor panel to effect multiple response modes; (c) development of a computerized algorithm to analyze the panel responses; (d) laboratory testing and calibration; (e) field testing. In the course of the project, mostly due to the change in the US partner, three modifications were introduced to the original objectives: (a) the scope of the project was expanded to include pharmaceuticals (with a focus on antibiotics) in addition to endocrine disrupting chemicals, (b) the computerized algorithm was not fully developed and (c) the field test was not carried out. Background: Chemical agents, such as pesticides applied at inappropriate levels, may compromise water quality or contaminate soils and hence threaten human populations. In recent years, two classes of compounds have been increasingly implicated as emerging risks in agriculturally-related pollution: endocrine disrupting compounds (EDCs) and pharmaceuticals. The latter group may reach the environment by the use of wastewater effluents, whereas many pesticides have been implicated as EDCs. Both groups pose a threat in proportion to their bioavailability, since that which is biounavailable or can be rendered so is a priori not a threat; bioavailability, in turn, is mediated by complex matrices such as soils. Genetically engineered biosensor bacteria hold great promise for sensing bioavailability because the sensor is a live soil- and water-compatible organism with biological response dynamics, and because its response can be genetically “tailored” to report on general toxicity, on bioavailability, and on the presence of specific classes of toxicants. In the present project we have developed a bacterial-based sensor panel incorporating multiple strains of genetically engineered biosensors for the purpose of detecting different types of biological effects. The overall objective as defined in the approved proposal was the development of a whole-cell sensor panel for the detection of endocrine disruption activities of agriculturally relevant chemicals. To achieve this goal several specific objectives were outlined: (a) The development of new genetically engineered wholecell sensor strains; (b) the combination of multiple strains into a single sensor panel to effect multiple response modes; (c) development of a computerized algorithm to analyze the panel responses; (d) laboratory testing and calibration; (e) field testing. In the course of the project, mostly due to the change in the US partner, three modifications were introduced to the original objectives: (a) the scope of the project was expanded to include pharmaceuticals (with a focus on antibiotics) in addition to endocrine disrupting chemicals, (b) the computerized algorithm was not fully developed and (c) the field test was not carried out. Major achievements: (a) construction of innovative bacterial sensor strains for accurate and sensitive detection of agriculturally-relevant pollutants, with a focus on endocrine disrupting compounds (UK and HUJ) and antibiotics (HUJ); (b) optimization of methods for long-term preservation of the reporter bacteria, either by direct deposition on solid surfaces (HUJ) or by the construction of spore-forming Bacillus-based sensors (UK); (c) partial development of a computerized algorithm for the analysis of sensor panel responses. Implications: The sensor panel developed in the course of the project was shown to be applicable for the detection of a broad range of antibiotics and EDCs. Following a suitable development phase, the panel will be ready for testing in an agricultural environment, as an innovative tool for assessing the environmental impacts of EDCs and pharmaceuticals. Furthermore, while the current study relates directly to issues of water quality and soil health, its implications are much broader, with potential uses is risk-based assessment related to the clinical, pharmaceutical, and chemical industries as well as to homeland security.
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Nelson, Daniel C. Resensitizing Resistant Bacteria to Antibiotics. Fort Belvoir, VA: Defense Technical Information Center, April 2011. http://dx.doi.org/10.21236/ada554271.

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