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Smolanka, V. I., V. M. Fedurtsya, and B. B. Pavlov. "Discogenic low back pain: interventional treatment." Pain medicine 3, no. 3 (November 22, 2018): 16–26. http://dx.doi.org/10.31636/pmjua.v3i3.2.
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Low back pain (LBP) is one of the most common causes of disability in the adult population. A significant place in its genesis is occupied by a degenerative-dystrophic diseases of intervertebral discs. The article highlights the classification and mechanism of discogenic pain origin. Various types of interventions aredescribed for this pathology: indications, specificities of carrying out manipulations and therapeutic effects, efficiency and possible complications of procedures.
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Rakhmatov, K. R. "RADIOFREQUENCY ABLATION OF FACET NERVES IN THE TREATMENT OF PAIN SYNDROMES IN DEGENERATIVE DISEASES OF THE SPINE." UZBEK MEDICAL JOURNAL 2, no. 5 (May 30, 2021): 45–48. http://dx.doi.org/10.26739/2181-0664-2021-5-9.
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The first results of radiofrequency ablation of facet nerves and its effectiveness in eliminating local chronic back pain and reflected pain vertebrogenic syndromes were studied in 122 patients. Thebest results were obtained in patients with spondyloarthrosis with a positive test blockade of the facet nerves. Spondyloarthrosis is the most common condition presenting as neck pain, although it usually appears as an incidental finding in older asymptomatic subjects in cervical radiographs.Keywords: back pain, reflex, pain, syndrome, facet nerve, high-frequency, exposure, spondyloarthrosis, syndrome, radiofrequency ablation.
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Ganuza, Carlos, Norman Shealy, and Nirman Koladia. "IDD Therapy in Back Pain Treatment: A Clinical Trial Comparing Key Diseases of Low Back Pain." Southern Medical Journal 98, Supplement (October 2005): S18. http://dx.doi.org/10.1097/00007611-200510001-00039.
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Solokha, O. A., L. T. Аkhmedzhanova, T. I. Kuzminova, and D. S. Lavrenenko. "Back pain: from diagnosis to treatment." Meditsinskiy sovet = Medical Council, no. 2 (March 4, 2020): 34–42. http://dx.doi.org/10.21518/2079-701x-2020-2-34-42.
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In today ‘s world, back pain is a heavy burden and leads to a decrease in the working capacity, quality of life of people. The choice of tactics of treatment of pain in a back is defined by the pain reason: nonspecific pain, the specific pain caused by serious diseases or a compression of a root. The most frequent cause of back pain is nonspecific pain due to myofascial, muscular-tonic syndrome, facet syndrome, and sacral-iliac joint dysfunction in lower back pain. The article presents clinical symptoms of these syndrome, as well as techniques of neuroorthopedic examination, which allow to detect one or more abrasions of back pain. To prevent acute non-specific pain, it is recommended to prescribe non-steroidal anti-inflammatory drugs (NSAID) and muscle relaxants. Along with pharmacological treatments, treatment of patients with back pain should be more comprehensive and include cognitive-behavioral therapy and kinesiotherapy. Determination of the source of back pain in neuroorthopedic examination makes it possible to carry out local therapy in stages using blockages with local anesthetics and glucocorticoids. In case of insufficient effectiveness of blockades, it is possible to carry out radiofrequency denervation of facet joints or sacral-iliac). Clinical and neuroorthopedic examination of a patient with back pain with identification of sources of pain, analysis of the causes that led to its development, adequate treatment and recommendations to prevent repeated exacerbations can significantly reduce the risk of chronization of back pain and improve the quality of life of patients.
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Mironov, S. P., G. I. Nazarenko, E. I. Polubentseva, A. M. Cherkashov, and V. I. Kuzmin. "Continuous improvement of the quality of medical care is the main direction of work of Russian orthopedic traumatologists (Part 2)*." N.N. Priorov Journal of Traumatology and Orthopedics 8, no. 1 (February 2, 2022): 3–10. http://dx.doi.org/10.17816/vto96614.
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Present work is a sequel to the publication presented in № 3, 2000. Projecting of the medical technological process is considered on the example of the hospital treatment of patients with low back degenerative diseases. Technologic chart for diagnosis and treatment of patients with spondylogenous low back pain for the inpatient treatment is given. High efficacy of the proposed technological approach to the treatment of lumbar spine degenerative diseases is proved by clinical results.
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Blumberg, H. M. "Treatment of Latent Tuberculosis Infection: Back to the Beginning." Clinical Infectious Diseases 39, no. 12 (December 15, 2004): 1772–75. http://dx.doi.org/10.1086/425620.
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Gorodnina, A. V., and A. V. Ivanenko. "Translational methods for the treatment of chronic back pain." Translational Medicine 9, no. 4 (November 25, 2022): 5–12. http://dx.doi.org/10.18705/2311-4495-2022-9-4-5-12.
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Background. Up to 83 % of the working population has a high level of social adaptation disorder due to the pain in the lumbosacral spine. The development of translational approaches in the treatment of degenerative diseases of the spine is becoming increasingly important. The key methods in the differentiated approach to the treatment are laser vaporization of the intervertebral disc and radiofrequency denervation of the facet joints in the case when the pain syndrome is facet-like.Objective. To evaluate the effectiveness of a differentiated approach in the use of minimally invasive surgical methods in patients with discogenic and vertebrogenic pain syndrome based on an analysis of the immediate results of treatment.Design and methods. A retrospective analysis of examination and treatment data of 101 patients with degenerative-dystrophic diseases of the lumbar spine, accompanied by pain, was carried out. In 29 (28.7 %) patients, laser vaporization of the intervertebral disc was performed; in 72 (71.3 %) cases, radiofrequency denervation of the facet joints of the lumbosacral spine was used.Results. Positive outcomes after laser vaporization were observed in 27 patients. A positive result was noted in 67 patients after radiofrequency destruction of the sinuvertebral nerve.Conclusions. Differentiated use of minimally invasive puncture methods for the treatment of osteochondrosis of the spine and adequate selection of patients for these procedures often lead to the positive result.
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Goold, P. C. "No way back for quinolones in the treatment of gonorrhoea." Sexually Transmitted Infections 82, no. 3 (June 1, 2006): 225–26. http://dx.doi.org/10.1136/sti.2005.018168.
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Marsh, A. T., L.-H. Cheah, and D. I. Hedderley. "Crop rotation with Brassica reduces disease in potato crops." New Zealand Plant Protection 62 (August 1, 2009): 404. http://dx.doi.org/10.30843/nzpp.2009.62.4848.
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A longterm trial (5 years) was conducted at a commercial property with a history of high incidence and severity of soilborne diseases Five rotational crops (potato pasture Brassica cereal and squash) were tested for their effects on soilborne diseases on potatoes These crops were grown in plots for about 4 months and then ploughed back into the soil 30 days prior to planting potatoes Soil applications of metalaxyl fungicide were used as a standard (control) treatment After four growing seasons there was evidence that rotational treatments particularly Treatment 2 (cereal Brassica crop) reduced the amount of diseased potatoes and the proportion of the crop that was diseased compared with the control treatment (potatoes and pasture with or without metalaxyl) (P0046 and 0016 respectively) Combining these results with harvest data from previous years there was no significant difference between the treatments in terms of yield per plant However there did appear to be a marginal difference (P01) in the proportion of the crop that was diseased with Treatment 4 (without Brassica crop) being higher than other treatments that had Brassica crops In previous work soil analysis had shown that a rotation with Brassica crops reduced the level of Phytophthora and other species of soilborne fungi compared with the same rotation without Brassica crops
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Berruti, Marco, Niccolò Riccardi, Diana Canetti, Sergio Lo Caputo, Lucia Taramasso, and Antonio Di Biagio. "Injectable Antiretroviral Drugs: Back to the Future." Viruses 13, no. 2 (February 2, 2021): 228. http://dx.doi.org/10.3390/v13020228.
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Current HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long commitment for the people living with HIV (PHIV). Injectable agents might represent a turning point in the care of PHIV, allowing less frequent administration of antiretroviral treatment (ART), more widespread use of pre-exposure prophylaxis (PrEP) and more stable drug levels in the blood, thus increasing the odds to get closer to end the HIV pandemic. The aim of this manuscript is to give a comprehensive review of injectable antiretrovirals that have been used in the past, which are available now, will be available in the future, and their role in the treatment of HIV infection
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Oral, H. Barbaros, Cüneyt Özakin, and Cezmi A. Akdiş. "Back to the Future: Antibody-Based Strategies for the Treatment of Infectious Diseases." Molecular Biotechnology 21, no. 3 (2002): 225–40. http://dx.doi.org/10.1385/mb:21:3:225.
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Park, Moon, Seong-Hwan Moon, Tae-Hwan Kim, JaeKeun Oh, Seon-Jong Lee, Ho Chang, and Jae-Hyuk Shin. "Paraspinal Muscles of Patients with Lumbar Diseases." Journal of Neurological Surgery Part A: Central European Neurosurgery 79, no. 04 (April 16, 2018): 323–29. http://dx.doi.org/10.1055/s-0038-1639332.
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Objective The treatment of atrophy or increased fat infiltration of the lumbar paraspinal muscles of patients with back pain, lumbar radiculopathy, or lumbar degenerative kyphosis is controversial. We review the literature on changes in the lumbar paraspinal muscles of these patients. Methods We searched Medline for relevant English-language articles and retrieved 25 articles published from 1993 to 2017 on changes in the lumbar paraspinal muscles; 21 met our study criteria. We categorized each article into three groups: randomized clinical trial, nonrandomized prospective study, or retrospective study. Results We found 1 randomized prospective, 3 nonrandomized prospective, and 17 retrospective studies. Atrophies of the multifidus muscle are found at the level of the L5 vertebral body in patients with back pain, lumbar radiculopathy, and lumbar degenerative kyphosis. Increased fat infiltration to the multifidus muscle was found in the patients with lumbar radiculopathy or lumbar degenerative kyphosis. However, there are controversies over fat infiltration to the multifidus muscle in the patients with back pain and the efficiency of a paramedian surgical approach to prevent the atrophy of the multifidus muscle. Conclusions Atrophy of the multifidus muscle was found in patients with back pain, lumbar radiculopathy, and lumbar degenerative kyphosis. There was increased fat infiltration to the multifidus muscle in those patients with lumbar radiculopathy or lumbar degenerative kyphosis.
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Perepanova, Tamara S., A. V. Kazachenko, P. L. Khazan, and Yu A. Malova. "Bacteriophage therapy: back to the future." Clinical Microbiology and Antimicrobial Chemotherapy 23, no. 1 (2021): 55–64. http://dx.doi.org/10.36488/cmac.2021.1.55-64.
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In connection with growing problem of antimicrobial resistance, the search for alternative treatments for infection is popular topic nowadays. This article represents an overview of published data on the therapeutic use of bacteriophages, specifically in urinary tract infections. The history of phage therapy of infectious diseases from the beginning of the 20th century to the present days is presented. The paper also discuss the mechanism of bacteriophages activity, differences between lytic and lysogenic phages, mechanisms of bacterial tolerance to phages and ways of its overcoming are. Authors present their own data on 30 years of clinical use of “bacteriophage cocktails” in the treatment and prevention of urological infection.
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Bicanic, Tihana, Robin Wood, Linda-Gail Bekker, Marta Darder, Graeme Meintjes, and Thomas S. Harrison. "Antiretroviral roll-out, antifungal roll-back: access to treatment for cryptococcal meningitis." Lancet Infectious Diseases 5, no. 9 (September 2005): 530–31. http://dx.doi.org/10.1016/s1473-3099(05)70197-3.
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Novikov, A. Yu, and M. B. Tsykunov. "Interventional treatment of lower back pain." Russian Osteopathic Journal, no. 3-4 (February 11, 2020): 44–53. http://dx.doi.org/10.32885/2220-0975-2019-3-4-44-53.
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Introduction. Low back pain takes one of the leading places among all non-communicable diseases, reaching 70 % of outpatient visits. In 90 % of cases the non-specific nature of back pain is observed. The most common causes of low back pain are myofascial pain syndrome, facet joint arthrosis, spinal stenosis, spondylolisthesis, discal hernias. If NSAIDs and muscle relaxants are the «gold standard» in the treatment of low back pain, interventional treatment needs further studies. This trial was conducted in order to determine the effectiveness of therapeutic blockades. The goal of research — to study the effectiveness of selective injections of pharmaceuticals into pain sources in case of low back pain based on clinical and instrumental studies.Materials and methods. The prospective, controlled, randomized trial was conducted from January 2018 to January 2019 at the Department of Neurosurgery and Medical Rehabilitation of the Bashkir State Medical University. 42 patients with low back pain, aged from 24 to 54 years, of which 28 (66,7 %) were men and 14 (33,3 %) were women took part in the research and were randomly divided into 2 groups. Patients of the main group (30 people) underwent interventional therapy, from 2 to 7 injections, depending on the severity of the pain syndrome and the duration of the disease. Patients of the control group — 12 people, received treatment in accordance with the standard of medical care in low back pain (analgesics, NSAIDs, muscle relaxants), as well as physiotherapy for 2 weeks daily. The study of the effectiveness of therapy included, along with the neurological examination, a neuroorthopedic instrumental examination. The depth of the lumbar lordosis, flexion and extension restrictions were measured using a curvimeter-goniometer, which also allows measuring the angle of tension symptoms (Lasegue, Wasserman). In order to study rotation and lateroflexion, instruments with a graduated scale were used. Muscle tone and tenderness of the structures of the spine were examined using a myotonometer-tensoalgimeter and a visual analogue scale (VAS). To interpret the data of a comprehensive neuroorthopedic examination, the results were converted into comparable units with the calculation of the integral indicator.Results. After selective intervention therapy in the main group, a more rapid relief of pain, a regression of neurological symptoms, manifested by the complete elimination or significant reduction of biomechanical and tonus disorders in the lower back were noted.Conclusion. Selective injections of pharmaceuticals into pain sources in low back pain are more effective than treatment with the use of analgesics, NSAIDs, muscle relaxants and physiotherapy, which allows to recommend them for wider use in clinical practice.
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Greeff, Oppel BW. "The pharmacotherapy of low back pain." South African Family Practice 60, no. 1 (March 17, 2018): 30–34. http://dx.doi.org/10.4102/safp.v60i1.4816.
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About 60–80% of patients visiting a physician have at some stage in their lives suffered from low back pain. The annual incidence in adults aged 35–55 years in developed countries is up to 45%.1 The differential diagnosis is broad and includes muscular strain, primary spine disease like disc herniation or degenerative arthritis, systemic diseases like metastatic cancer and regional diseases like aortic aneurisms. In the majority of cases, a specific diagnosis cannot be made. Most patients will improve in 1–4 weeks and will only need treatment for the acute symptoms after the initial history and physical examination. If, however, the pain recurs or worsens, the patient must be thoroughly examined and a specific diagnosis can become a challenge.
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Santos, P., GM Pinto, A. Pereira, T. Cruz, A. Afonso, and J. Cardoso. "Sequential treatment of angiosarcoma of the back with liposomal doxorubicin and radiotherapy." Journal of the European Academy of Dermatology and Venereology 19, no. 6 (November 2005): 779–80. http://dx.doi.org/10.1111/j.1468-3083.2005.01275.x.
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Dobrokhotova, Juliia E., and Kseniia V. Morozova. "Opportunities for ovarian reserve preservation in the treatment of oncological diseases." Gynecology 21, no. 6 (April 29, 2020): 21–25. http://dx.doi.org/10.26442/20795696.2019.6.190709.
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This article presents the data of multi-year research on the problem of ovarian reserve preservation in cancer patients. The review includes 64 literary sources. The review provides the main methods for ovarian function preservation during the treatment of malignant diseases in patients of reproductive age. Given the increasing number of cancer patients in the group of patients of reproductive age, modern medicine is faced with the task not only to provide effective anticancer treatment, but also to try to preserve ovarian function in order to maintain hormonal levels and fertility. Unfortunately, most cancer treatment methods inhibit ovarian function. Thanks to modern approaches, there are medicinal methods for protecting against ovarian inhibition, which allows to maintain hormonal function and come back to solve reproductive problems after recovering from cancer.
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Abid, Rameesha, Hassan Waseem, Jafar Ali, Shakira Ghazanfar, Ghulam Muhammad Ali, Abdelbaset Mohamed Elasbali, and Salem Hussain Alharethi. "Probiotic Yeast Saccharomyces: Back to Nature to Improve Human Health." Journal of Fungi 8, no. 5 (April 24, 2022): 444. http://dx.doi.org/10.3390/jof8050444.
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Saccharomyces cerevisiae var. boulardii is best known for its treatment efficacy against different gastrointestinal diseases. This probiotic yeast can significantly protect the normal microbiota of the human gut and inhibit the pathogenicity of different diarrheal infections. Several clinical investigations have declared S. cerevisiae var. boulardii a biotherapeutic agent due to its antibacterial, antiviral, anti-carcinogenic, antioxidant, anti-inflammatory and immune-modulatory properties. Oral or intramuscular administration of S. cerevisiae var. boulardii can remarkably induce health-promoting effects in the host body. Different intrinsic and extrinsic factors are responsible for its efficacy against acute and chronic gut-associated diseases. This review will discuss the clinical and beneficial effects of S. cerevisiae var. boulardii in the treatment and prevention of different metabolic diseases and highlight some of its health-promising properties. This review article will provide fundamental insights for new avenues in the fields of biotherapeutics, antimicrobial resistance and one health.
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Masala, Salimei, Lacchè, Marcia, and Massari. "Overview on Percutaneous Therapies of Disc Diseases." Medicina 55, no. 8 (August 12, 2019): 471. http://dx.doi.org/10.3390/medicina55080471.
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Low back pain is an extremely common pathology affecting a great share of the population, in particular, young adults. Many structures can be responsible for pain such as intervertebral discs, facet joints, nerve roots, and sacroiliac joints. This review paper focuses on disc pathology and the percutaneous procedures available to date for its treatment. For each option, we will assess the indications, technical aspects, advantages, and complications, as well as outcomes reported in the literature and new emerging trends in the field.
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Babelyuk, D. V., and Y. M. Polihas. "Kinesiotaping as one of the methods of treatment of low back pain syndrome." Pain medicine 3, no. 1 (March 7, 2018): 56–66. http://dx.doi.org/10.31636/pmjua.v3i1.88.
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About 80 % of adults feel pain in their backs at a definite moment of life. That’s also the most frequent reason why people lose their efficiency. It’s also the key factor due to which workable people miss their working days. Recently, the frequency of sickness rate of low back pain syndrome is getting higher and higher. For examples, according to the data of the organization, which aims at analyzing pathological conditions and diseases, which cause death or looseness of efficiency, in 1990 in the USA, low back pain syndrome took the sixth place, but in 2010 back pain went up to the third place, giving the way only to ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD). So, we can imagine how common, widespread and serious for modern world became the problem of back pain. That’s why, only now doctors throughout the world are starting to form their separate individual researches into one qualitative and useful list of recommendations to begin an effective fight with this serious medical and social problem. Kinesiotaping (“kinesio” – movement + “tape”) – is an effective treatment and rehabilitation method of muscle and joints injuries with the help of special elastic tapes – namely kinesio tapes. The article focuses on the method of kinesiotaping and the ways of its usage for treating low back pain syndrome. The research also highlights the history of appearance and development of kinesiotaping as a method of treatment, physiological features of kinesio tape and ways of its usage in everyday medical practice. Besides analyzing recent researches in this field we provide descriptions of three clinical cases from our own medical practice which proves the effectiveness of kinesiotaping in the complex treatment of low back pain syndrome. After deep analysis of the patients’ condition we can state that due to kinesiotaping which is used together with other physiotherapeutic methods and exercises, they recover quickly than those who do not undergo kinesiotaping procedures.
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Shavlovskaya, O. A., I. A. Bokova, and N. I. Shavlovskiy. "Meloxicam in pain syndrome treatment of comorbid diseases patients." Meditsinskiy sovet = Medical Council, no. 19 (December 1, 2021): 209–15. http://dx.doi.org/10.21518/2079-701x-2021-19-209-215.
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The issue nonsteroidal anti-inflammatory drugs (NSAIDs) use safety is associated with a high frequency of adverse events (AEs) from the gastrointestinal tract and cardiovascular risks. Patients with lower back pain (LBP) and osteoarthritis (OA), as a rule, have comorbid diseases, such as arterial hypertension (AH), coronary heart disease (CHD), gastrointestinal tract (GIT) diseases, which significantly complicates the appointment of NSAIDs. The main guideline in NSAIDs appointment is the selective ability to inhibit cyclooxygenase-1 and -2 (COX). The ratio of the activity of NSAIDs when blocking COX-1/COX-2 allows us to judge their potential toxicity. And, then higher the selectivity of NSAIDs, then lower its toxicity. For example, the ratio of COX-1/COX-2 in meloxicam is 0.33, diclofenac – 2.2, tenoxicam – 15, piroxicam – 33, indomethacin – 107. To the predominantly selective COX-2 NSAIDs include meloxicam, which has little effect on the GIT, the lowest relative risk (RR) of complications from the cardiovascular system (CVS). The therapeutic efficacy of meloxicam is comparable to piroxicam and diclofenac. A number of studies have shown the high efficacy of meloxicam, both with per oral (p/o) administration (7.5–15 mg/d), and with intramuscular (i/m) administration (1.5 ml), and when injected into trigger zones. Both with p/o and the injectable form of meloxicam has minimal GIT AEs and absence local reaction in the injection area. The drug can be recommended both as a combination therapy and prescribed in monotherapy.
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ÖRMECİ, Necati, Özgün Ömer ASİLLER, Cemil YAĞCI, Tuğrul ÖRMECİ, Zeynep ELLİK, Çağdaş KALKAN, and Atilla İLHAN. "Muscle hydatid diseases: percutaneous treatment with Örmeci technique." Journal of Health Sciences and Medicine 5, no. 3 (May 30, 2022): 732–39. http://dx.doi.org/10.32322/jhsm.1011096.
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Aim: To present results of percutaneous treatment with Örmeci technique for muscle hydatid diseases.
Material and Method: Twelve patients (9 male, 3 female) with 16 hydatid cysts (10 CE Type 1, 6 CE Type3B) were treated by percutaneous treatment with Örmeci technique. The percutaneous puncture was performed under sonographic guidance using a 22-gauge Chiba needle as a one-step procedure in CE type 1 and 3A. However, two to six Chiba needles according to size of the cysts were used in different locations at the same time in the cyst of CE type 2, and 3B). For every 1 cm of the long diameter of the cyst lesion, 3cc of fluid from the cysts was aspirated, which was almost the same amount of cc in volume for the CE type 1 and CE type 3A hydatid cysts. A 2cc of pure alcohol (96 %) and 1cc of polidocanol 1% (ethoxysclerol 1%, Kreussler Pharma, Wiesbaden, Germany) were injected into the cysts right after the aspiration of CE type 1 and type 3A, without the aspiration of CE type 2 and 3B, for each centimeter of the long diameter of the cysts. The total amount of pure alcohol and polidocanol were injected equally among the CE type 2 and type 3B cyst’s needles. It was waited for five minutes for all scolexes to be killed and the needle/or needles were taken back. The patients with hydatid disease were followed up mean 34.75 ±14.39 (maximum 65-minimum 15) months.
Findings: Fifteen out of 16 hydatid cysts (93.75%) cured. We had two complications of treatment. One patient had an abscess in the cyst after the percutaneous treatment. After the percutaneous drainage, patient was cured well, and he had no symptoms during the follow up. Another patient had torpidity in his leg after the treatment. After three months, he had no symptoms.
In Conclusion, Percutaneous treatment with Örmeci technique is outpatient based, successful, safe, repeatable, cheap and It can be used as an alternative treatment in selected patients.
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Redeker, I., S. Moustakis, S. Tsiami, X. Baraliakos, I. Andreica, B. Buehring, J. Braun, and U. Kiltz. "AB0823 TREATMENT WITH ADALIMUMAB IN PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES: A STUDY OF TREATMENT TRAJECTORIES ON A PATIENT LEVEL IN CLINICAL PRACTICE." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1435.2–1436. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1838.
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Background:There is evidence that drug retention rates to adalimumab (ADA) in patients (pts.) with chronic inflammatory rheumatic diseases (CIRD) are impaired by loss of efficacy and adverse events, and that about 50% of users had discontinued ADA within 5 years (1). With the introduction of ADA biosimilars in October 2018, non-medical switching from originator to ADA biosimilars is now increasingly part of daily practice in rheumatologic care.Objectives:The aim was to study treatment trajectories over two years in pts. with CIRD receiving originator ADA.Methods:Pts. with CIRD on originator ADA who switched to ADA biosimilar from October 2018 onwards were identified and followed until 2020. Disease activity (ASDAS), physical function (HAQ, BASFI), and changes in treatment were documented every 3 months. The four predefined treatment trajectories “continued ADA biosimilar therapy”, “back-switch to originator ADA therapy”, “switch to other biological (b) disease modifying anti-rheumatic drug (DMARD) therapy”, and “stopped bDMARD therapy /death /drop out” were used to compare characteristics of pts. with different trajectories.Results:A total of 111 CIRD pts. on treatment with originator ADA were switched to ADA biosimilar (Table 1). The majority of pts. 75 continued therapy with ADA biosimilar (Figure 1 next page) while 16% switched back to originator ADA, 7% switched to a different bDMARD, and 9% either stopped treatment (n=9) or died (n=1). Pts. who continued ADA biosimilar were more frequently male, older or with a longer disease duration than those who switched therapy back to originator ADA and those who switched to a different bDMARD (Table 1). The previous duration on originator ADA treatment was increased in patients who continued ADA biosimilar compared to those who switched therapy back to originator ADA and those who switched to a different bDMARD. There was more functional impairment (HAQ, BASFI) and higher disease activity (ASDAS) in pts. who switched compared to those who continued ADA biosimilar therapy (Table 1). Treatment with csDMARDs and glucocorticoids was increased in pts. who continued ADA biosimilar therapy, while pts. who switched therapy had more previous bDMARD therapies (Table 1).Table 1.Characteristics of patients at baseline for the entire group and stratified by treatment trajectoryTotal groupN=111 (100%)Treatment trajectorycontinued ADA biosimilar therapyN=75 (67.6%)back-switch to originator ADA therapyN=18 (16.2%)switch to different bDMARD therapyN=8 (7.2%)no bDMARD therapy /death /drop outN=10 (9.0%)Age, y51.2 (14.5)51.5 (13.6)50.6 (16.8)43.5 (9.5)56.4 (19.0)Women, No. (%)46 (41.4)27 (36.0)9 (50.0)6 (75.0)4 (40.0)RA23 (20.7)17 (22.7)2 (11.1)1 (12.5)3 (30.0)axSpA68 (61.3)47 (62.7)11 (61.1)6 (75.0)4 (40.0)PsA15 (13.5)7 (9.3)4 (22.2)1 (12.5)3 (30.0)Other diagnoses5 (4.5)4 (5.3)1 (5.6)0 (0.0)0 (0.0)Disease duration, median (IQR), y5.0 (2.0-8.0)5.0 (2.0-9.0)3.5 (2.0-6.0)2.0 (1.0-5.5)4.5 (2.0-8.0)Duration previous originator ADA therapy40.7 (27.7)45.3 (27.8)35.0 (25.2)20.3 (24.7)32.3 (25.1)DAS283.0 (1.0)2.9 (1.0)3.4 (1.0)-3.3 (1.2)CRP, median (IQR), mg/L0.2 (0.1-0.3)0.1 (0.1-0.2)0.2 (0.0-0.5)0.2 (0.2-1.3)0.3 (0.2-0.4)HAQ score1.3 (0.8)1.1 (0.7)1.7 (0.8)-1.8 (1.0)ASDAS2.2 (1.1)2.0 (1.0)3.0 (1.2)2.7 (0.9)2.3 (0.2)BASFI3.5 (2.6)3.0 (2.5)5.4 (2.4)3.4 (1.6)5.4 (1.6)+values are given as mean (SD)Conclusion:Two thirds of pts. who switched to ADA biosimilar remained on this therapy for 2 years. As many as 16% of pts. switched back to ADA originator. Whether or to what degree this was influenced by nocebo effects needs further study. The same is true for the effect of functional impairment – it would be interesting to know whether this was due to inflammation or structural damage.References:[1]Neovius M et al. Ann Rheum Dis 2015; 74:354-360[2]The study was funded by Hexal Germany.Figure 1.Treatment trajectories of ADA therapy in patients with CIRD during two years ADA: adalimumab; bDMARD: biological disease modifying anti-rheumatic drug.Disclosure of Interests:None declared
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Zduńska, Anna, Sebastian Zduński, Katarzyna Nowicka, and Agnieszka Rudnicka. "Balneotherapy and Physiotherapy in Chronic Pain Syndrome of the Lumbosacral Spine. Review of the literature." Acta Balneologica 62, no. 2 (2020): 119–26. http://dx.doi.org/10.36740/abal202002109.
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Back pain is a common disease and although it can be located in any of its cervical, thoracic and lumbosacral sections, however the vast majority of patients complain of lumbosacral pain. Back pain syndromes has become a challenge for modern rehabilitation, both in the issue of the prevention as well as therapy. A major problem for people with back pain is progressive disability, and thus a deterioration in the quality of life. Despite many treatment methods and health care resources devoted to back pain, disability and burden are increasing. An important place in the therapy of back pain syndromes is occupied by physical methods and health resort treatment. The work presents the use of balneotherapy and physiotherapy in the most common back pain syndromes, i.e. in chronic diseases of the intervertebral discs and degenerative changes of the lumbosacral spine.
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Ford, Nathan, Andrew Ball, Rachel Baggaley, Marco Vitoria, Daniel Low-Beer, Martina Penazzato, Lara Vojnov, et al. "The WHO public health approach to HIV treatment and care: looking back and looking ahead." Lancet Infectious Diseases 18, no. 3 (March 2018): e76-e86. http://dx.doi.org/10.1016/s1473-3099(17)30482-6.
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Harwanti, Siti, Budi Aji, and Nur Ulfah. "EFFECT OF BACK EXERCISE TO DECREASE LOW BACK PAIN OF BATIK ARTISANTS IN KAUMAN VILLAGE, SOKARAJA." Kesmas Indonesia 11, no. 1 (January 30, 2019): 45. http://dx.doi.org/10.20884/1.ki.2019.11.1.1434.
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ABSTRACT
Low back pain ( LBP ) is a musculoskeletal disorder that occurs in the lower back which can be caused by various diseases and activity of the body being less good. One effort to overcome the LBP is back exercise. The research purpose is to find out the effect of back exercise therapy which concern to lowering painful complaint of batik artisants in Kauman village Sokaraja subsdistrict. This research is using Quasi Experiment technique phenomenological non equivalen control group design (pre -post test). Sample taking is using purposive sampling technique. Data analysis use Friedman experiment for treatment group and Repeated Annova experiment for control group. Experiment analysis is different between treatment group and control group with using Mann Whitney experiment. The result of Friedman experiment in treatment group shows that p-value=0,000(p<0,05), it means the therapy those given is effective to lowering painful complaint. The result of Repeated Annova experiment in control group shows that p-value=0,234(p>0,05), it means the painful complaint seems not different in control group. The result of Mann Whitney experiment shows that p-value=0,000(p<0,05) it means there are differences between painful complaint in treatment group and control group after doing back exercise. There is the effect by giving back exercise therapy which concern to lowering the complaint of low back pain for batik artisants in Kauman village Sokaraja subdistrict.
Key words: Handmade Batik, Low back pain, back exercise
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Abid, Mohammad, Jyoti, Kapil Kumar, Roomi khan, Salman Ali, Phool Chandra, Renu Rani, and Najam Ali Khan. "Assessment of Leucorrhea diseases in female students." Journal of Scientific and Innovative Research 5, no. 4 (August 25, 2016): 116–18. http://dx.doi.org/10.31254/jsir.2016.5402.
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Leucorrhoea also spelled leucorrhoea, flow of a whitish, yellow, or greenish discharge from the vagina of the female that may be normal or that may be a sign of infection. The present study was done in female student of the different departments of IFTM University. Total number of 200 female students was taken into the study. In this study more prevalent symptoms was found that irritation and itching on genital organs which could be worse at night (95%), followed by sedentary life styles (85%) and foul-smell vaginal discharges (70%), moderately prevalent symptoms were found constipation (55%),stress (60%),frequent mood changes (50%) pain in stomach/lower back pain (40%), and less prevalent symptoms were black dark circle around the eyes (25%), anorexia (16%), period irregular (10%). Students should be recommended for treatment and provide awareness and prevention of leucorrhoea by maintain good hygiene, exercise, natural treatment especially in the genital areas to prevent any bacterial infections.
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Bleckwenn, Markus, and Elisabeth Märker-Hermann. "Rückenschmerzen: Wann muss man einweisen?" DMW - Deutsche Medizinische Wochenschrift 144, no. 10 (May 2019): 665–69. http://dx.doi.org/10.1055/a-0759-7982.
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AbstractIn the case of acute back pain, the indication for inpatient diagnosis and therapy is rarely given. The indication is provided if a potentially dangerous disease situation is suspected and if the pain is immobilizing or cannot be controlled on an outpatient basis. The high treatment numbers in German hospitals indicate that there is overuse in the treatment of back pain. Back pain, especially acute low back pain, is a frequent consultative activity of general practitioners. Serious diseases of the spine occur in only about 1 % of cases in GP practices. Identifying potentially dangerous disease outcomes requires a detailed history and thorough physical examination of the unclothed patient. “Red flags”, together with the overall clinical impression of the patient, provide decisive warnings for urgently needed back pain. Common non-specific low back pain can be treated on an outpatient basis by prescribing painkillers and instructions for exercise by GPs.
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Romeyke, Tobias, Elisabeth Noehammer, and Harald Stummer. "Patient-Reported Outcomes Following Inpatient Multimodal Treatment Approach in Chronic Pain-Related Rheumatic Diseases." Global Advances in Health and Medicine 9 (January 2020): 216495612094881. http://dx.doi.org/10.1177/2164956120948811.
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Introduction Musculoskeletal disorders may cause chronic pain, which is associated with deterioration in physical well-being, functions, and quality of life. There are worldwide shortfalls in the care that is provided to the affected patients. Holistic, interdisciplinary care is rare. Monomodal therapeutic approaches dominate when health-care resources are scarce. In this study, we test the patient-relevant outcomes of multimodal treatment for rheumatic diseases that are associated with pain and check for remuneration. Methods We performed a retrospective data analysis of an inpatient multimodal treatment. The target parameter was the patient perspective, which we assessed by means of Patient-Reported Outcomes (PRO). We applied the Visual Analogue Scale (mental and physical condition), the Heidelberg Short Early Risk Assessment Questionnaire, the Pain Disability Index, and the pain grading according to Kohlmann/Raspe (N = 375 patients). We also investigated compensation for inpatient treatments with and without multimodal treatments. Moreover, we compared Diagnosis-Related Group remuneration with and without complex treatment. Results After implementing a multimodal treatment, improved mental (mood) status was significantly better (Wilcoxon signed-rank test, P < . 001), despite high levels of pain (Kohlmann/Raspe) reported on admission. Apart from the underlying rheumatic disease, 111 patients also reported chronic back pain, which was improved following the treatment ( t test, P < . 001). Subjective impairments associated with pain were significantly lower at the end of the hospital stay (Wilcoxon signed-rank test, P < . 001). Compensation for inpatient treatments with multimodal treatments increased noticeably in German hospitals in 2016 to 2019, while remunerations for monomodal treatments show mixed results. Conclusion PROs regarding mood, pain, and perceived impairments improved following the multimodal complex treatment. Compensation of hospitals should take into account additional performance requirements of holistic treatments, whereby the promotion and further studies of PROs are recommended.
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ZuWallack, Richard. "A History of Pulmonary Rehabilitation: Back to the Future." Advances in Respiratory Medicine 77, no. 3 (April 23, 2009): 298–301. http://dx.doi.org/10.5603/arm.27819.
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Pulmonary rehabilitation is defined as “an evidence-based, multidisciplinary, and comprehensive intervention for patients with chronic respiratory diseases who are symptomatic and often have decreased daily life activities. Integrated into the individualized treatment of the patient, pulmonary rehabilitation is designed to reduce symptoms, optimize functional status, increase participation, and reduce health care costs through stabilizing or reversing systemic manifestations of the disease” [...]
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West, Christina E., Maria C. Jenmalm, Anita L. Kozyrskyj, and Susan L. Prescott. "Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward." Expert Review of Clinical Immunology 12, no. 6 (March 4, 2016): 625–39. http://dx.doi.org/10.1586/1744666x.2016.1147955.
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Gogu, Anca Elena, Agneta Pusztai, Alina Zorina Stroe, Daniel Docu Axelerad, and Any Docu Axelerad. "Back Pain in Rare Diseases: A Comparison of Neck and Back Pain between Spinal Cord Ischemia and Spinal Dural Arteriovenous Fistula." Brain Sciences 10, no. 9 (September 7, 2020): 618. http://dx.doi.org/10.3390/brainsci10090618.
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Neck and back pain may be noted like a first symptom in rare diseases: spinal cord ischemia and spinal dural arteriovenous fistula (SDAVF). Spinal cord ischemia is a rarer pathology, compared with cerebral ischemia, yet the morbidity and mortality are comparable in both cases; furthermore, classifying the acute loss of function in the spine, encountered in spinal cord ischemia as an important neurological entity. SDAVF presents the same clinical symptoms as spinal cord ischemia, but even though it has a progressive character, the impact in the quality of patients’ lives being equally as important. Between August 2012–August 2017 we admitted through the hospital emergency department 21 patients with spinal cord ischemia and 11 patients with SDAVF (only self-casuistry). Demographic (age, gender), clinical, imagistic (Magnetic Resonance Angiography, Magnetic Resonance Imaging), paraclinical data as well as history, time to diagnosis, the visual analogue scale for pain (VAS score), risk factors, surgical and medical treatment, evolution, neurorehabilitation, were all used to compare the two lots of patients. The aim of this study was to observe potential differences in the demographics, symptomatology, VAS scores and treatment in comparison for spinal cord ischemia and SDAVF, to facilitate the further recognition and management in these diseases. In group A we have 21 patients with spinal cord ischemia (14 females, 7 males). The median age was 41.3 years (range 19–64). The median time to diagnosis was 7 h. The most frequent symptoms were acute neck or back pain at onset (100%), motor deficits (95.24%), sensory loss (85.72%), and sphincters problems (90.48%). The most common location was the lumbosacral spine (14 cases; 66.67%; p-value = 0.03) for spinal cord ischemia and the thoracic spine (7 cases, 63.64%; p-value = 0.065) for SDAVF. The treatment of spinal cord ischemia was medical. In group B we included 11 patients (6 females, 5 males). The median age was 52.6 years (range 28–74). The median time to diagnosis was 3 months (range 2 days–14 months). Patients have progressive symptoms: neck or back pain (100%), gait disturbances (100%) and abnormalities of micturition (100%). The treatment of SDAVF was surgical occlusion of fistula. The proportion of severe VAS score (7–10) in patients with spinal cord ischemia was significantly higher than that in patients with SDAVF (100% vs. 18, 19%; p-value = 0.051). Taking into consideration that the usual findings and diagnosis of spinal cord ischemia and SDAVF are still challenging for neurologists and in some cases the difficulties are related to technical limitations, we consider these entities to be rare but very important for the life of our patients. Patients were grouped into spinal cord ischemia and SDAVF status and those with acute or chronic pain conditions, measured by the VAS score. Patients with spinal cord ischemia develop acute neurological symptoms. They are much younger than the patients with SDAVF and the recovery rate is higher. Patients with SDAVF develop a progressive myelopathy and they suffer considerable neurological deficits. Imaging the lesions with MR angiography or MRI, we can confirm the diagnosis.
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Becheva, Maria Stamova Vakrilova, Stefka Аchkova Ivanova, and Angelina Georgieva Kirkova-Bogdanova. "Pharmaceutical care and active treatment in patients with osteochondrosis." Pharmacia 68, no. 1 (February 9, 2021): 223–26. http://dx.doi.org/10.3897/pharmacia.68.e62944.
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According to the International Classification of Diseases, osteochondrosis is included in the group of diseases of the musculoskeletal system, mainly the spine. The mechanism of the disease is expressed in the disturbance of blood circulation, which nourishes the bone, and hence the damage to bone and cartilage tissue. Objective: This paper aims to present the effect of applied pharmacological and active treatment in 10 patients diagnosed with lumbar osteochondrosis. Methods: We conducted a comprehensive treatment of 10 patients diagnosed with lumbar osteochondrosis without any neurological symptoms during the period 2017–2020. This pharmacological and active treatment lasted from 15 to 17 days. The intensity of the pain symptoms, the general mobility of the spine, and the mobility of the lumbar spine were measured to determine the deficit of the patients. The strength of the flexor and extensor muscles of the body was tested. Results: A decrease in pain intensity, increase in the strength of the abdominal and back muscles and improvement of the mobility of the back muscles were found in all patients after the complex treatment. As a result of the therapy, a reduction in the patient’s dysfunctions and the risk of developing disabilities was found. Conclusion: The application of a multidisciplinary approach in patients with osteochondrosis is of great importance for reducing pain intensity and achieving a good functional recovery of motor and stabilizing function of the muscles of the spine.
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Hendrickx, S., E. Eberhardt, A. Mondelaers, S. Rijal, N. R. Bhattarai, J. C. Dujardin, P. Delputte, P. Cos, and L. Maes. "Lack of correlation between the promastigote back-transformation assay and miltefosine treatment outcome." Journal of Antimicrobial Chemotherapy 70, no. 11 (August 7, 2015): 3023–26. http://dx.doi.org/10.1093/jac/dkv237.
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Bulatov, A. V., D. A. Rzayev, V. S. Klimov, and A. V. Evsyukov. "Semi-rigid minimally invasive transpedicular fixation in the treatment of degenerative diseases of the lumbar spine." Russian journal of neurosurgery 20, no. 3 (September 19, 2018): 19–30. http://dx.doi.org/10.17650/1683-3295-2018-20-3-19-30.
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The study objective is to analyze the effectiveness of the use of minimal invasive polyetheretherketone (PEEK) rod systems in the treatment of lumbar spine degenerative diseases.Materials and methods. The minimal invasive semi-rigid stabilization using PEEK rod systems was performed in 24 patients (4 (17 %) male and 20 (83 %) female) patients (mean age 46.3 ± 8.4, ranging from 32 to 63). The average follow-up duration was 15 months. Inclusion criteria: mechanical low back pain, White–Panjabi instability: 5 points, degenerative changes of the disc by C. Pfirrmann scale: II–IV grade. Follow-up at the 6 and 12 months postoperatively.Results. In the postoperative period, the majority of patients had a complete or significant regression of pain (on average, from 6.3 to 1.8 points on the visual analog scale). The Oswestry disability index decreased from 64/66 [64; 68] to 33/34 [32; 36] in 6 months (p <0.001) and 18/17 [16; 18] in 12 months (p <0.001). Before surgery, the height of the operated disk was 0.96 cm, after 1 year decreased to 0.91 cm. Range of rotary motion in the operated segment in all cases did not exceed 6°.Conclusion. The PEEK rod fixation in patients with mechanical low back pain provides good and excellent clinical results on the I. Macnab scale in 83.4 % of cases. Within 12 months, the minimal volume of movements on the operated segment remains, without signs of continued degeneration of adjacent intervertebral discs.
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Кундер, Е. В. "The use of aceclofenac for analgesic and anti-inflammatory purposes in musculoskeletal diseases." Рецепт, no. 3 (August 19, 2022): 269–75. http://dx.doi.org/10.34883/pi.2022.25.3.003.
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В статье изложены сведения об эффективности и безопасности применения ацеклофенака при лечении пациентов с заболеваниями костно-мышечной системы. Результаты многочисленных клинических исследований указывают на сопоставимую или превосходящую эффективность ацеклофенака при лечении анкилозирующего спондилита, ревматоидного артрита, боли в нижней части спины, остеоартрита. Ацеклофенак характеризуется хорошей переносимостью, редко вызывает нежелательные явления и обладает высокой приверженностью пациентов к лечению. The article presents the information about the effectiveness and safety of the use of аceclofenac in the treatment of patients with diseases of the musculoskeletal system. The results of numerous clinical studies indicate comparable or superior efficacy of аceclofenac in the treatment of ankylosing spondylitis, rheumatoid arthritis, lower back pain, osteoarthritis. Aceclofenac is characterized by good tolerability, rarely causes adverse events and has a high adherence of patients to treatment.
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Naftali Ben Haim, Liron, and Elad Moisseiev. "Drug Delivery via the Suprachoroidal Space for the Treatment of Retinal Diseases." Pharmaceutics 13, no. 7 (June 26, 2021): 967. http://dx.doi.org/10.3390/pharmaceutics13070967.
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The suprachoroidal space (SCS), a potential space between the sclera and choroid, is becoming an applicable method to deliver therapeutics to the back of the eye. In recent years, a vast amount of research in the field has been carried out, with new discoveries in different areas of interest, such as imaging, drug delivery methods, pharmacokinetics, pharmacotherapies in preclinical and clinical trials and advanced therapies. The SCS can be visualized via advanced techniques of optical coherence tomography (OCT) in eyes with different pathologies, and even in healthy eyes. Drugs can be delivered easily and safely via hollow microneedles fitted to the length of the approximate thickness of the sclera. SCS injections were found to reach greater baseline concentrations in the target layers compared to intravitreal (IVT) injection, while agent clearance was faster with highly aqueous soluble molecules. Clinical trials with SCS injection of triamcinolone acetonide (TA) were executed with promising findings for patients with noninfectious uveitis (NIU), NIU implicated with macular edema and diabetic macular edema (DME). Gene therapy is evolving rapidly with viral and non-viral vectors that were found to be safe and efficient in preclinical trials. Here, we review these novel different aspects and new developments in clinical treatment of the posterior segment of the eye.
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Fazzari, Maria, Giulia Lunghi, Elena Chiricozzi, Laura Mauri, and Sandro Sonnino. "Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition." Biomedicines 10, no. 2 (February 2, 2022): 363. http://dx.doi.org/10.3390/biomedicines10020363.
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Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in the middle of the 1950s. From this time, neurochemical studies suggested that gangliosides, and particularly GM1 ganglioside, display neurotrophic and neuroprotective properties. The involvement of GM1 in modulating neuronal processes has been studied in detail by in vitro experiments, and the results indicated its direct role in modulating the activity of neurotrophin-dependent receptor signaling, the flux of calcium through the plasma membrane, and stabilizing the correct conformation of proteins, such as α-synuclein. Following, in vivo experiments supported the use of ganglioside drugs for the therapy of peripheral neuropathies, obtaining very positive results. However, the clinical use of gangliosides for the treatment of central neurodegeneration has not been followed due to the poor penetrability of these lipids at the central level. This, together with an ambiguous association (later denied) between ganglioside administration and Guillain-Barrè syndrome, led to the suspension of ganglioside drugs. In this critical review, we report on the evolution of research on gangliosides, on the current knowledge on the role played by gangliosides in regulating the biology of neurons, on the past and present use of ganglioside-based drugs used for therapy of peripheral neuropathies or used in human trials for central neurodegenerations, and on the therapeutic potential represented by the oligosaccharide chain of GM1 ganglioside for the treatment of neurodegenerative diseases.
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Исаева, Юлия Владимировна, Елена Юрьевна Есина, and Ирина Сергеевна Добрынина. "ADDICTION TO TREATMENT OF PRIMARY LOW-BACK PAIN IN PATIENTS WITH ARTERIAL HYPERTENSION." СИСТЕМНЫЙ АНАЛИЗ И УПРАВЛЕНИЕ В БИОМЕДИЦИНСКИХ СИСТЕМАХ, no. 1 (April 19, 2021): 65–69. http://dx.doi.org/10.36622/vstu.2021.20.1.009.
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В статье изучается приверженность к лечению первичной боли в нижней части спины у больных гипертонической болезнью в зависимости от получаемого лечения. Определение приверженности к лечению у лиц обеих групп проводилось с помощь теста Мориски-Грина. Анализировались факторы риска дегенеративных заболеваний позвоночника у пациентов гипертонической болезнью, длительность и интенсивность болевого синдрома в зависимости от получаемого лечения, социальный статус больных, корреляционные взаимосвязи между интенсивностью болевого синдрома у пациентов гипертонической болезнью и дегенеративными заболеваниями позвоночника и использованием в лечении медикаментозных и немедикаментозных методов. Выделили две группы пациентов: получавших только медикаментозное лечение, и медикаментозное и не медикаментозное лечение по поводу дегенеративного заболевания позвоночника. Приверженность к лечению у пациентов 1-й и 2-й группы была недостаточной (средний балл 3,35±0,6 и 3,5±0,6 соответственно). У пациентов 1-й группы среди факторов риска, преобладали: длительное пребывание в вынужденном неудобном положении (29%), малоподвижный образ жизни (19%) и курение (14%). У больных 2-й группы: работа, связанная с частыми изменениями положения туловища (19%), работа, связанная с подъемом тяжестей (17%) и длительное пребывание в неудобном положении (17%). Интенсивность болевого синдрома в области пояснично-крестцового отдела позвоночника у больных 1-й группы была сильной, а у пациентов 2-й группы - умеренной. Длительность болевого синдрома у пациентов 1-й группы составила 5,65±1,4 дня, у пациентов 2-й группы - 6,10±1,7 дня. Низкий социальный статус был выявлен у 5 (25%) 1-й группы и 7 (35%) 2-й группы The article examines the adherence to treatment of primary lower back pain in patients with hypertension, depending on the treatment received. Determination of treatment adherence in both groups was performed using the Morisky-Green test. The risk factors for degenerative diseases of the spine in patients with hypertension, the duration and intensity of pain depending on the treatment received, the social status of patients, the correlation between the intensity of pain in patients with hypertension and degenerative diseases of the spine and the use of medication and non-drug methods in treatment were analyzed. There were two groups of patients: those who received only medical treatment, and medical and non-medical treatment for degenerative diseases of the spine. Adherence to treatment in patients of group 1 and 2 was insufficient (average score 3.35±0.6 and 3.5±0.6, respectively). In group 1 patients, the following risk factors prevailed: prolonged stay in a forced uncomfortable position (29%), sedentary lifestyle (19%), and Smoking (14%). In group 2 patients: work associated with frequent changes in the position of the trunk (19%), work associated with lifting weights (17%) and prolonged stay in an uncomfortable position (17%). The intensity of pain in the lumbosacral spine in patients of group 1 was strong, and in patients of group 2-moderate. The duration of pain in group 1 patients was 5.65±1.4 days, in group 2 patients-6.10±1.7 days. Low social status was found in 5 (25%) of the 1st group and 7 (35%) of the 2nd group
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Жукембаева, А. М., Г. Д. Жаманбай, А. М. Барат, С. Т. Дюсенгалиева, У. Г. Шакиманова, Б. С. Есенби, Б. А. Таженова, А. Д. Аскербек, and А. А. Айтахметова. "FEATURES OF PAIN SYNDROME IN THE LUMBAR REGION AMID INFLAMMATORY GYNECOLOGICAL DISEASES." Vestnik, no. 1 (June 17, 2021): 9–13. http://dx.doi.org/10.53065/kaznmu.2021.75.18.003.
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Проведен анализ особенностей развития болевого синдрома в нижних отделах спины, в проекции поясничного отдела позвоночника на фоне неспецифических воспалительных заболеваний придатков матки (НВЗПМ) у 148 женщин, находившихся на амбулаторном лечении в гинекологическом отделении поликлиники №5 г. Алматы в 2019-2020 г.г. Установлено, что у 79 (53,4±4,1%) из них отмечался болевой синдром в нижней части спины и сопутствующие ему скованность и ограничение подвижности поясничного отдела позвоночника на фоне обострения НВЗПМ.Критериями для анализа являлись динамика клинической симптоматики НВЗПМ и болевого синдрома с учетом его локализации на фоне проводимого лечения. При этом было проведено сравнение результатов, зафиксированных при поступлении и через 14 суток после начала лечения НВЗПМ. Перспективным представляется продолжить исследования и оценить влияние спинально-генитального рефлекса на течение первичного патологического очага в придатках матки. The development of the features of pain syndrome in the lower back, in the projection of the lumbar spine amid nonspecific inflammatory diseases of the uterine appendages (NIDUA) in 148 women who were on outpatient treatment in the gynecological department of polyclinic # 5 in Almaty in 2019-2020 were analized. It was found that 79 (53.4 ± 4.1%) of them had pain in the lower back and concomitant stiffness and limitation of the mobility of the lumbar spine amid exacerbation of NIDUA. The analysis criteria were the dynamics of the clinical symptomatology of NIDUA and pain syndrome, taking into account its localization amid treatment. At the same time, a comparison was made between the results recorded at admission and 14 days after the start of the NIDUA treatment. It seems promising to continue research and assess the impact of the spinal-genital reflex on the course of the primary pathological focus in the uterine appendages.
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Kavita, Kavita, Suresh N. Hakkandi, and Manjunath Akki. "PAIN MANAGEMENT IN KATISHOOLA: A CASE STUDY." International Ayurvedic Medical Journal 9, no. 11 (November 15, 2021): 2909–13. http://dx.doi.org/10.46607/iamj4509112021.
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Lower Back Pain can have causes that aren’t due to underlying diseases and this pain refers to the pain that usual- ly begins in the lower back region, radiating to the sacroiliac regions and buttocks.[1] People with chronic pain often find it difficult to cope with work, family and social activities which is the significant cause of disability worldwide. Eighty percent of the population is affected by this symptom sometimes in life.[2] Increased preva- lence of low back pain and temporary and reduced success rates in invasive contemporary treatment measures has drawn considerable attention towards alternative, effective, non-invasive treatment modalities. Katishoola, a Vata vyadhi diagnosed with cardinal symptoms as Pain in Kati Pradesha. In Ayurveda, a holistic approach has been adopted that includes the use of oral Ayurvedic formulations, Panchakarma procedures like Snehana karma (unc- tion therapy), Swedana karma (sudation therapy) etc. [3] Here In this article a case of low Back Pain treated with Kati Pichu with Masha taila with good outcomes are reported. Keywords: Katishoola, Low Back Pain, Masha Taila, Kati Pichu
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Das, Sumit, Manas Kumar Sanyal, and Debamoy Datta. "Artificial Intelligent Embedded Doctor (AIEDr.)." International Journal of Big Data and Analytics in Healthcare 4, no. 2 (July 2019): 34–56. http://dx.doi.org/10.4018/ijbdah.2019070103.
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This article focuses on the development of a diagnostic model for low back pain management, a mathematical model describing the cause of the disease and an inclusive hardware implementation with artificial intelligence (AI). It has been observed that the greater part of the people in developing countries cannot afford the cost of this treatment due to low financial status. Moreover, a continuous assessment is not made for continuous monitoring of the patient's status. The problem of back pain develops slowly and if some early assessments can be made, then the treatment becomes effective. The proposed method developed in this article is based on galvanic skin response (GSR). GSR is used to monitor the pain of the patients and a modified back-pain management algorithm is used for tackling the correlation between stress and pain. The system continuously monitors the condition of a patient and if any symptoms of low back pain (LBP) develop, it immediately diagnoses diseases and chronic pains, and it recommends going to a doctor.
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Plotnikova, E. Y., and L. G. Vologzhanina. "Antacids and their role in treatment of digestive diseases in pregnant women." Herald of Pancreatic Club 47, no. 2 (April 29, 2020): 82–88. http://dx.doi.org/10.33149/vkp.2020.02.10.
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Antacids are drugs that can neutralize or buffer the hydrochloric acid of the stomach without affecting its production. History of the clinical use of antacids dates back several centuries. The article discusses the advantages and disadvantages of modern antacids, provides a classification of drugs of this group, considers the mechanisms of their action, explains the term “acid-neutralizing activity”, lists indications for the use of antacids and possible adverse effects of antacid therapy. The results of various foreign and domestic studies on the use of acid-suppressive drugs, including antacids, are presented.
Currently, antacids continue to be used for the symptomatic treatment of certain acid-dependent diseases, including gastroesophageal reflux disease (GERD). Due to a number of physiological reasons, GERD often worries pregnant women, most often in the third trimester of pregnancy. The choice of acid-suppressing agents in pregnant women is extremely limited, because the possibility of prescribing any drugs in this category of patients is determined by the safety of the drug, its tolerability, and the absence of teratogenic effects. Features of the mechanism of action of antacids, their favorable pharmacological properties determine the possibility of using modern combined drugs of this group during pregnancy. Relieving heartburn in pregnant women through the use of non-absorbable combined antacids is supported by the FDA, the European guidelines for the treatment of GERD. The article lists antacid drugs registered in the pharmaceutical market, special attention is paid to drugs approved for use during pregnancy.
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Joaquim, Andrei Fernandes. "Initial approach to patients with acute lower back pain." Revista da Associação Médica Brasileira 62, no. 2 (April 2016): 186–91. http://dx.doi.org/10.1590/1806-9282.62.02.188.
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Summary Low back pain is in one of the most common reasons for seeking medical care in emergency care units, and also the second most common cause of work absenteeism. The recognition of red flags for serious diseases such as tumors and fractures, through proper history-taking and clinical examination, is essential for proper treatment and to rule out differential diagnoses. In the absence of suspected severe underlying disease, subsidiary radiological examinations are unnecessary. Analgesic and anti-inflammatory drugs are the treatment of choice and can be cautiously associated with muscle relaxants and opioids in more severe cases. Most patients will have complete improvement of symptoms after a few months, but a minority can develop chronic low back pain or present with recurrent episodes. The proper understanding of all of the above can optimize results and avoid diagnostic and therapeutic errors.
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Dammak, Azza, Fernando Huete-Toral, Carlos Carpena-Torres, Alba Martin-Gil, Cristina Pastrana, and Gonzalo Carracedo. "From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment." Pharmaceutics 13, no. 9 (August 31, 2021): 1376. http://dx.doi.org/10.3390/pharmaceutics13091376.
Full textAbstract:
Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration and diabetic retinopathy, have their origin in the posterior segment of the eye, making their physiopathology both complex and interconnected. In addition to the age factor, these diseases share the same mechanism disorder based essentially on oxidative stress. In this context, the imbalance between the production of reactive oxygen species (ROS) mainly by mitochondria and their elimination by protective mechanisms leads to chronic inflammation. Oxidative stress and inflammation share a close pathophysiological process, appearing simultaneously and suggesting a relationship between both mechanisms. The biochemical end point of these two biological alarming systems is the release of different biomarkers that can be used in the diagnosis. Furthermore, oxidative stress, initiating in the vulnerable tissue of the posterior segment, is closely related to mitochondrial dysfunction, apoptosis, autophagy dysfunction, and inflammation, which are involved in each disease progression. In this review, we have analyzed (1) the oxidative stress and inflammatory processes in the back of the eye, (2) the importance of biomarkers, detected in systemic or ocular fluids, for the diagnosis of eye diseases based on recent studies, and (3) the treatment of posterior ocular diseases, based on long-term clinical studies.
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Jay, Sarika, and B. V. A. N. S. S. Prabhakar Rao. "Intelligent Healthcare System for Recuperation and Inoculation of Communicable Diseases." Journal of Physics: Conference Series 2115, no. 1 (November 1, 2021): 012037. http://dx.doi.org/10.1088/1742-6596/2115/1/012037.
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Abstract Human life gets interrupted a lot when a communicable disease starts in a society. People are alerted a lot on a different basis and eventually, it leads to difficulty for continuing their normal life. This paper is focused on a communicable disease, the COVID-19, which gave an outbreak for all world counties into a state where their fellow human had to stop their daily job and stay back at home. Common people find it difficult to get treatment when they are identified as positive and also most of them lack the awareness of post covid recovery. The idea of this work is to create a healthcare system that initiates right from the covid test, appropriate treatment according to severity, post-recovery, and vaccination awareness and jabs. These units will have less human interaction and they will be fully automated till in need of pure doctor consultation. The automated system is programmed to identify the infection, its severity and prescribe the treatment accordingly, and follow up recovery needs. On-side, automated vaccination system will allow direct walk-in, identify the customer and do the needful.
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Liu, Sheng, Xiaoqin Gong, Hanping Li, and Yuan Li. "The Origin, Application and Mechanism of Therapeutic Climbing: A Narrative Review." International Journal of Environmental Research and Public Health 19, no. 15 (August 6, 2022): 9696. http://dx.doi.org/10.3390/ijerph19159696.
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As an innovative exercise therapy, therapeutic climbing (TC) has attracted more attention than ever before in recent years. In this review of the related studies on TC, the authors explore its origin and development; summarize its therapeutic effect in treating depression, low back pain and other diseases; and further analyze its underlying mechanism. According to the literature, TC was primarily applied in the field of orthopedics and then was gradually used in neurology, psychiatry and psychology. It provides a new means for the treatment of depression, lower back pain, multiple sclerosis and other diseases. There are two potential mechanisms: physiological and psychological. In the future, exercise effects, adverse effects and exercise prescriptions of TC should be explored with large samples and high-quality randomized controlled trials.
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Park, Jong-Beom. "Paradigm Shift of Interspinous Device Surgery for Degenerative Lumbar Diseases." Back Bone Journal 3, no. 1 (2022): 4–6. http://dx.doi.org/10.13107/bbj.2022.v03i01.032.
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Instrumented fusion surgery is an effective surgery for severe degenerative lumbar diseases and can achieve satisfactory clinical outcomes with a high fusion rate. However, due to extensive nature and loss of segmental motion, instrumented fusion can cause complications and adjacent segment disease, and some patients require second surgery. On the contrary, decompression alone is an effective surgery for moderate degenerative lumbar diseases and can achieve satisfactory clinical outcomes. However, failed back surgery syndrome, such as recurrent lumbar disc herniation or spinal stenosis, can occur at the segment of prior surgery, and some patients also require second surgery. In clinical practice, there are indications for instrumented fusion surgery or decompression alone. However, for some cases, it is difficult to decide which surgery is appropriate for the patients; such a situation is called a grey zone (Fig. 1). Instrumented fusion surgery can be excessive, while decompression alone can involve segmental imbalance or problems postoperatively. Interspinous device surgery (ISD) can be considered for grey zone of degenerative lumbar diseases as new solution. According to the traditional concepts, diseased lumbar segment with instability is a cause of low back pain and can require fusion. However, in clinical situations, fusion does not always correlate with successful outcomes. While about 10–20% of solid fusion patients complain of persistent low back pain, some non-union patients do not complain of low back pain. These results lead to questions and uncertainty regarding fusion surgery. First, it is unclear if lumbar instability is a cause of low back pain. Second, it must be determined if fusion surgery is necessary for lumbar instability. Recently, the biomechanical concept of the cause of low back pain has changed. Increased load transmission to facet joints and increased intradiscal pressure to the posterior part of a disc are considered important causes of low back pain. Therefore, spine surgeons view degenerative lumbar diseases differently, resulting in a paradigm shift in surgery of degenerative lumbar diseases. ISD surgery is a dynamic stabilization surgery with an action mechanism of distraction of narrow interspinous space: ISD can widen the spinal canal and neural foramen to achieve indirect decompression of neural structures. In addition, ISD can restore normal lordosis and offset abnormal load shift of facet joints and increased intradiscal pressure to the posterior part of the disc to relieve low back pain. Based on the concept and action mechanism, good indications of ISD surgery are moderate lumbar spinal stenosis (Fig. 2), lumbar disc herniation (Fig. 3), and internal disc derangement (Fig. 4) associated with flexible extension instability or segmental imbalance, such as retrolisthesis or hyperlordosis, which can be reduced in flexion. In contrast, contraindications of ISD surgery are severe lumbar spinal stenosis, flexion instability, degenerative or isthmic spondylolisthesis, rigid extension instability of segmental imbalance that cannot be reduced in flexion, and multilevel degenerative lumbar scoliosis. In our experiences of about 20 years with primary ISD surgery and revision surgery for failures of ISD surgery, the most common cause of failure of ISD surgery is inappropriate indication or patient selection. Another important cause of failure is incorrect surgical technique such as stand-alone use of ISD without decompression, excessive over-distraction (by over-sized ISD), and supraspinous ligament injury or spinous process fracture. These incorrect surgical techniques cause poor surgical outcomes and might require revision surgery. Based on these outcomes, the following advice is offered for successful ISD surgery for degenerative lumbar diseases. First, ISD surgery should be performed for patients with good indications. Second, ISD implantation should be performed after limited decompression including removal of a hypertrophied ligamentum flavum to preserve segmental stability (Fig. 5). In our BMC Musculoskeletal Disorders Publication (Cho et al.) [1], we performed 15-year survivorship analysis of 94 patients with single-level lumbar disc herniation who underwent discectomy and DIAM implantation. We aimed to provide the longest follow-up evidence on the efficacy of DIAM implantation for single-level lumbar disc herniation. The results showed that 8.5% of the patients underwent reoperation at the DIAM implantation level during the 15-year follow-up. The mean time to reoperation was 6.5 years. Kaplan–Meier analysis showed a cumulative survival rate of the DIAM implant of 99% at 1 year, 97% at 5 years, 93% at 10 years, and 92% at 15 years after surgery. Our results showed that DIAM implantation significantly decreased reoperation rate for single-level lumbar disc herniation in 15-year survivorship analysis. This study provides the strongest evidence for the efficacy of DIAM implantation for the treatment of single-level lumbar disc herniation. In our view, this paper, coupled with our previous paper (Sur et al.) [2], settles the debate on the efficacy of DIAM implantation for the treatment of moderate lumbar spinal stenosis or lumbar herniation associated flexible extension instability or segmental imbalance.
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Krupinsky, J. M., and D. L. Tanaka. "Leaf Spot Diseases on Winter Wheat Influenced by Nitrogen, Tillage, and Haying after a Grass-Alfalfa Mixture in the Conservation Reserve Program." Plant Disease 85, no. 7 (July 2001): 785–89. http://dx.doi.org/10.1094/pdis.2001.85.7.785.
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When contracts for the Conservation Reserve Program (CRP) expire, highly erodible land that had a long-term vegetative cover composed of grasses or grass-legume mixtures may be converted back to cropland. Considering that some of the same leaf spot pathogens found on grasses can cause diseases on wheat, the management practices used to convert these lands were evaluated for their effect on winter wheat leaf spot diseases. In a 3-year spring wheat-winter wheat-pea crop rotation, the major leaf spot diseases on winter wheat were tan spot and Stagonospora nodorum blotch. Removal of hay or leaving hay in the plots when converting grassland to cropland had no significant effect on leaf spot diseases, indicating that the residue from the grass-alfalfa crop did not influence leaf spot diseases on winter wheat. Tillage treatments did not influence the amount of disease in 1996, but with higher precipitation levels in 1999, higher disease severities were associated with the no tillage treatment. Higher levels of crop residue associated with the no tillage treatment could potentially carry over plant pathogens from one crop to the next. The severity of leaf spot diseases was consistently lower when nitrogen was applied, indicating the importance of nitrogen application when converting grassland to cropland.