Relevant bibliographies by topics / Back – Diseases – Treatment

Academic literature on the topic 'Back – Diseases – Treatment'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Back – Diseases – Treatment"

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Smolanka, V. I., V. M. Fedurtsya, and B. B. Pavlov. "Discogenic low back pain: interventional treatment." Pain medicine 3, no. 3 (November 22, 2018): 16–26. http://dx.doi.org/10.31636/pmjua.v3i3.2.

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Low back pain (LBP) is one of the most common causes of disability in the adult population. A significant place in its genesis is occupied by a degenerative-dystrophic diseases of intervertebral discs. The article highlights the classification and mechanism of discogenic pain origin. Various types of interventions aredescribed for this pathology: indications, specificities of carrying out manipulations and therapeutic effects, efficiency and possible complications of procedures.
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Rakhmatov, K. R. "RADIOFREQUENCY ABLATION OF FACET NERVES IN THE TREATMENT OF PAIN SYNDROMES IN DEGENERATIVE DISEASES OF THE SPINE." UZBEK MEDICAL JOURNAL 2, no. 5 (May 30, 2021): 45–48. http://dx.doi.org/10.26739/2181-0664-2021-5-9.

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The first results of radiofrequency ablation of facet nerves and its effectiveness in eliminating local chronic back pain and reflected pain vertebrogenic syndromes were studied in 122 patients. Thebest results were obtained in patients with spondyloarthrosis with a positive test blockade of the facet nerves. Spondyloarthrosis is the most common condition presenting as neck pain, although it usually appears as an incidental finding in older asymptomatic subjects in cervical radiographs.Keywords: back pain, reflex, pain, syndrome, facet nerve, high-frequency, exposure, spondyloarthrosis, syndrome, radiofrequency ablation.
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Ganuza, Carlos, Norman Shealy, and Nirman Koladia. "IDD Therapy in Back Pain Treatment: A Clinical Trial Comparing Key Diseases of Low Back Pain." Southern Medical Journal 98, Supplement (October 2005): S18. http://dx.doi.org/10.1097/00007611-200510001-00039.

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Solokha, O. A., L. T. Аkhmedzhanova, T. I. Kuzminova, and D. S. Lavrenenko. "Back pain: from diagnosis to treatment." Meditsinskiy sovet = Medical Council, no. 2 (March 4, 2020): 34–42. http://dx.doi.org/10.21518/2079-701x-2020-2-34-42.

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In today ‘s world, back pain is a heavy burden and leads to a decrease in the working capacity, quality of life of people. The choice of tactics of treatment of pain in a back is defined by the pain reason: nonspecific pain, the specific pain caused by serious diseases or a compression of a root. The most frequent cause of back pain is nonspecific pain due to myofascial, muscular-tonic syndrome, facet syndrome, and sacral-iliac joint dysfunction in lower back pain. The article presents clinical symptoms of these syndrome, as well as techniques of neuroorthopedic examination, which allow to detect one or more abrasions of back pain. To prevent acute non-specific pain, it is recommended to prescribe non-steroidal anti-inflammatory drugs (NSAID) and muscle relaxants. Along with pharmacological treatments, treatment of patients with back pain should be more comprehensive and include cognitive-behavioral therapy and kinesiotherapy. Determination of the source of back pain in neuroorthopedic examination makes it possible to carry out local therapy in stages using blockages with local anesthetics and glucocorticoids. In case of insufficient effectiveness of blockades, it is possible to carry out radiofrequency denervation of facet joints or sacral-iliac). Clinical and neuroorthopedic examination of a patient with back pain with identification of sources of pain, analysis of the causes that led to its development, adequate treatment and recommendations to prevent repeated exacerbations can significantly reduce the risk of chronization of back pain and improve the quality of life of patients.
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Mironov, S. P., G. I. Nazarenko, E. I. Polubentseva, A. M. Cherkashov, and V. I. Kuzmin. "Continuous improvement of the quality of medical care is the main direction of work of Russian orthopedic traumatologists (Part 2)*." N.N. Priorov Journal of Traumatology and Orthopedics 8, no. 1 (February 2, 2022): 3–10. http://dx.doi.org/10.17816/vto96614.

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Present work is a sequel to the publication presented in № 3, 2000. Projecting of the medical technological process is considered on the example of the hospital treatment of patients with low back degenerative diseases. Technologic chart for diagnosis and treatment of patients with spondylogenous low back pain for the inpatient treatment is given. High efficacy of the proposed technological approach to the treatment of lumbar spine degenerative diseases is proved by clinical results.
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Blumberg, H. M. "Treatment of Latent Tuberculosis Infection: Back to the Beginning." Clinical Infectious Diseases 39, no. 12 (December 15, 2004): 1772–75. http://dx.doi.org/10.1086/425620.

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Gorodnina, A. V., and A. V. Ivanenko. "Translational methods for the treatment of chronic back pain." Translational Medicine 9, no. 4 (November 25, 2022): 5–12. http://dx.doi.org/10.18705/2311-4495-2022-9-4-5-12.

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Background. Up to 83 % of the working population has a high level of social adaptation disorder due to the pain in the lumbosacral spine. The development of translational approaches in the treatment of degenerative diseases of the spine is becoming increasingly important. The key methods in the differentiated approach to the treatment are laser vaporization of the intervertebral disc and radiofrequency denervation of the facet joints in the case when the pain syndrome is facet-like.Objective. To evaluate the effectiveness of a differentiated approach in the use of minimally invasive surgical methods in patients with discogenic and vertebrogenic pain syndrome based on an analysis of the immediate results of treatment.Design and methods. A retrospective analysis of examination and treatment data of 101 patients with degenerative-dystrophic diseases of the lumbar spine, accompanied by pain, was carried out. In 29 (28.7 %) patients, laser vaporization of the intervertebral disc was performed; in 72 (71.3 %) cases, radiofrequency denervation of the facet joints of the lumbosacral spine was used.Results. Positive outcomes after laser vaporization were observed in 27 patients. A positive result was noted in 67 patients after radiofrequency destruction of the sinuvertebral nerve.Conclusions. Differentiated use of minimally invasive puncture methods for the treatment of osteochondrosis of the spine and adequate selection of patients for these procedures often lead to the positive result.
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Goold, P. C. "No way back for quinolones in the treatment of gonorrhoea." Sexually Transmitted Infections 82, no. 3 (June 1, 2006): 225–26. http://dx.doi.org/10.1136/sti.2005.018168.

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Marsh, A. T., L.-H. Cheah, and D. I. Hedderley. "Crop rotation with Brassica reduces disease in potato crops." New Zealand Plant Protection 62 (August 1, 2009): 404. http://dx.doi.org/10.30843/nzpp.2009.62.4848.

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A longterm trial (5 years) was conducted at a commercial property with a history of high incidence and severity of soilborne diseases Five rotational crops (potato pasture Brassica cereal and squash) were tested for their effects on soilborne diseases on potatoes These crops were grown in plots for about 4 months and then ploughed back into the soil 30 days prior to planting potatoes Soil applications of metalaxyl fungicide were used as a standard (control) treatment After four growing seasons there was evidence that rotational treatments particularly Treatment 2 (cereal Brassica crop) reduced the amount of diseased potatoes and the proportion of the crop that was diseased compared with the control treatment (potatoes and pasture with or without metalaxyl) (P0046 and 0016 respectively) Combining these results with harvest data from previous years there was no significant difference between the treatments in terms of yield per plant However there did appear to be a marginal difference (P01) in the proportion of the crop that was diseased with Treatment 4 (without Brassica crop) being higher than other treatments that had Brassica crops In previous work soil analysis had shown that a rotation with Brassica crops reduced the level of Phytophthora and other species of soilborne fungi compared with the same rotation without Brassica crops
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Berruti, Marco, Niccolò Riccardi, Diana Canetti, Sergio Lo Caputo, Lucia Taramasso, and Antonio Di Biagio. "Injectable Antiretroviral Drugs: Back to the Future." Viruses 13, no. 2 (February 2, 2021): 228. http://dx.doi.org/10.3390/v13020228.

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Current HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long commitment for the people living with HIV (PHIV). Injectable agents might represent a turning point in the care of PHIV, allowing less frequent administration of antiretroviral treatment (ART), more widespread use of pre-exposure prophylaxis (PrEP) and more stable drug levels in the blood, thus increasing the odds to get closer to end the HIV pandemic. The aim of this manuscript is to give a comprehensive review of injectable antiretrovirals that have been used in the past, which are available now, will be available in the future, and their role in the treatment of HIV infection
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Dissertations / Theses on the topic "Back – Diseases – Treatment"

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Briggs, Virginia G. "Injection Treatment for Lower Back Pain in Older Adults with Lumbar Spinal Stenosis: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/439.

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Background:Lower back pain is one of the most common health-related complaints in the adult population. Thirty percent of Americans 65 years and older reported symptoms of lower back pain in 2004. With an aging population, the proportion of people over the age of 65 is expected to reach 20% by the year 2030. Because of this increase in older adults, lumbar spinal stenosis (LSS) associated with arthritic changes will also likely increase. In older adults, lower back pain is most often caused by degenerative lumbar spinal stenosis. Stenosis is the narrowing ofthe spinal canal, causing pressure on the nerve roots and is frequently treated surgically. Lumbar spinal stenosis is one of the most common reasons for back surgery in patients 65 years and older 2. However, risks associated with surgery increase with age 3-5 and older patients may choose non-surgical treatment for their lower back pain, including injection treatment. Injection treatment, usually consisting of anti-inflammatory medications and analgesics, has improved since the mid-1990's when fluoroscopic guidance was developed. Information about injection treatment for lower back pain is limited, especially in the older population. An extensive review of published literature regarding injection treatment revealed a paucity of information about older adults diagnosed with lumbar spinal stenosis. In this study, three aims were designed to gain more information about the effectiveness of injection treatment in older patients with lumbar spinal stenosis. In the first (retrospective) study, information about receipt of second injections and time between injections was collected to examine injection usage. In the second and third (prospective) studies, information about pain relief and functional return following injection treatment was collected to examine the effectiveness of injection treatment in patients age 60 and older diagnosed with lumbar spinal stenosis. To our knowledge, such results have not been repolted for this population in the literature. Objective:Injection treatment is a commonly used non-surgical procedure to alleviate lower back pain in older adults. However, older patients do not have enough information about how long pain relief will last after treatment or the amount of pain relief and functional return they will experience. These studies focused on three topics: 1) usage of injection treatment; 2) effectiveness of injection treatment on pain relief; 3) effectiveness of injection treatment on functional return. In addition, the variations of the effectiveness were examined by selected patient attributes. Methods:In a retrospective study, medical records of patients aged 60 years or older from a high volume dedicated spine center at the University of Massachusetts Memorial Hospital were retrospectively reviewed. This study included those diagnosed with degenerative LSS, who had not received an injection for lower back pain within six months, and whom were treated between June I, 2006 and May 31, 2007. In two prospective studies, patients scheduled for lumbar injection treatment between January 1 and June 30, 2008 were selected from the University of Massachusetts Memorial Hospital Spine Center. Selection criteria included patients age 60 and over, diagnosed with degenerative lumbar spinal stenosis and no previous lumbar injection within 6 months or lumbar surgery within 2 years. The Pain sub-score of the SF-36 questionnaire was used to measure pain at baseline and at one and three months post injection. The Physical Component Score (PCS) of the SF-36 questionnaire and the Oswestry Disability Index (ODI) were used to measure function at baseline and at one and three months post injection. Variations in longitudinal changes in scores by patient characteristics were analyzed in both unadjusted (univariate) analyses using one-way analysis of variance (ANOVA), and adjusted (multiple regression) analyses using linear mixed effects models. Results: In the retrospective cohort, the mean age of the cohort was 68, 64% were female, 59% were married, with a mean Body Mass index of 32 kg/m2. Of 92 eligible patients, 57% returned for a second injection within six months of the first. The mean number of months between injections was 4.8 for all patients, ranging from 1 to 22 months. When patient characteristics were examined, the only variable that showed a statistically significant difference was age. Patients aged 70 years and older were found to be 67% less likely to return for a second injection when compared to patients age 60-69 (OR=0.33 (0.12 - 0.94)p In the prospective cohort, information was collected on 62 patients. Mean Pain scores improved significantly from baseline to one month (14.1 points), and from baseline to three months (8.3 points). Post injection changes in Pain scores varied by Body Mass Index (BMI) and baseline emotional health. Based on a linear mixed effects model analysis, higher baseline emotional health, as measured by the SF-36 Mental Component Score (MCS>50), was associated with greater reduction in pain over three months when compared to lower emotional health (MCS Conclusion: Patients over age 70 do not return for repeat injection as frequently as patients age 60-69. In addition, each year a patient ages over age 60, they are 10% less likely to return for a repeat injection. Lower back pain in older adults with LSS is clinically significantly alleviated after injection treatment. In addition, injection treatment for LSS is associated with return of lost function needed for daily living activities in older adults. Pain relief and functional return varies by patient personal and clinical characteristics. Higher emotional health was associated with more pain relief and more functional return experienced over three months following injection treatment. Additional information is needed about why older patients do not return for second injections at the same rate as younger patients and how emotional health affects response to injection treatment in older adults.
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Neto, Carlos Tucci. "Tradução, adaptação cultural e confiabilidade da versão em português brasileiro do questionário DRAM Distress Risk Assessment Method) para avaliação psicométrica em indivíduos com dor lombar." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-06112018-151013/.

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A dor na coluna vertebral é a principal causa de incapacidade no mundo, com altas taxas de prevalência global. A partir de estudos sobre a fisiologia da dor e suas relações com estados psicológicos, tornou-se essencial a avaliação psicológica dos indivíduos com quadros dolorosos, para selecionar os perfis mais favoráveis às diferentes formas de tratamento. O questionário DRAM (Distress Risk Assessment Method) foi desenvolvido como instrumento de triagem para portadores de dor na coluna vertebral subclassificando os indivíduos em quatro grupos distintos (normal, sob risco, somático e depressivo), conforme a pontuação dos dois questionários que compõem o DRAM (MSPQ e Zung). O objetivo desse estudo é traduzir e adaptar o DRAM para o português brasileiro da versão original em inglês, além de analisar a confiabilidade da versão traduzida e adaptada. Segundo a metodologia IQOLA, consagrada em inúmeras publicações, foi desenvolvida uma versão em português brasileiro que foi aplicada a uma amostra inicial de 30 pacientes e a seguir à amostra final de 85 indivíduos dos três centros participantes portadores de dor lombar. Os resultados comprovaram a confiabilidade e reprodutibilidade da versão traduzida e adaptada do questionário DRAM com índice de Cronbach alfa de 0,815 para o MSPQ e 0,794 para o Zung e coeficiente de correlação intraclasse de 0,688 para o MSPQ e 0,659 para o Zung. Tais dados permitiram concluir que a versão do questionário DRAM traduzida e adaptada culturalmente para o português brasileiro é confiável e está disponível para uso na prática clínica
Back pain is the leading disability cause worldwide, with high global prevalence rates. Based on studies regarding pain physiology and its relation to emotional distress conditions, psychological evaluation became essential to determine the most favorable patient profiles to distinct therapeutic approaches. DRAM (Distress Risk Assessment Method) has been developed as screening instrument for patients with lumbar pain, classifying them in subgroups as normal, at risk, distressed somatic and distressed depressive, based on the two components of DRAM scores (MSPQ and Zung questionnaires). The objective of this study is to translate and culturally adapt DRAM to Brazilian Portuguese language, and determine the final version reliability. As proposed by IQOLA method, a Brazilian Portuguese version of DRAM has been applied to an initial sample of 30 patients and finally to a 85 individuals from three participant centers. Results confirmed the reliability and reproducibility of DRAM in its Brazilian Portuguese final version: Cronbach alpha of 0.815 (MSPQ) and 0.794 (Zung) and ICC (intraclass correlation coefficient) of 0.688 (MSPQ) and 0.659 (Zung), thus concluding that the presented DRAM version in Brazilian Portuguese is reliable as available to clinical practice use
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Borg, Karin. "Sickness Absence with Musculoskeletal Diagnoses : An Eleven-Year Follow-Up of Young Persons." Doctoral thesis, Linköping : Univ, 2003. http://www.ep.liu.se/diss/med/07/86/index.html.

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Brose, Amy. "The treatment of chronic low back pain with traditional Chinese medicine." 2004. http://www.ocomlibrary.org/images/PDF/studentpapers/amybrosemendenhall.pdf.

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Richardson, Grant Walter. "The effect of differing clinical settings on chiropractic patients suffering from mechanical low back pain." Thesis, 2007. http://hdl.handle.net/10321/157.

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Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban University of Technology, 2007 xviii, 140 leaves
Each healing encounter, and every treatment, has specific and non-specific treatment effects. Non – specific effects, or placebo effects, are the benefits felt by the patients because of the nature of the healing encounter. Although difficult to quantify and control, a number of authors recognize that the non-specific component of management has an additive effect on the overall clinical outcome. It has been reported that due to the physical interaction and social nature of chiropractic, there is a strong non-specific component in the management process, but to what extent it facilitates in the healing encounter is unknown. It has also been shown that spinal manipulation has a clinical effect which exceeds that of placebo; therefore it is possible for its effect to be muted or amplified, depending on the presence or absence of non-specific effects. For the above reasons this study was conducted in an attempt to map the size of the non-specific effect in the healing encounter by manipulating the practice setting in which the patients were treated.
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Higgs, Renee Joy. "The relative effect of manipulation and core rehabilitation in the treatment of acute mechanical low back pain in sedentary patients." Thesis, 2007. http://hdl.handle.net/10321/503.

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Dissertation submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Durban University of Technology, 2007.
The aim of this research was to investigate the relative effectiveness of manipulation versus core rehabilitation in the treatment of acute mechanical low back pain in sedentary patients. Recent research has found that dysfunction of the primary core stabiliser muscles is linked with an increasing number of the general population suffering from low back pain; this is thought to be due to the fact that people in general are living more sedentary lifestyles. The Aims and Objectives of this study were to determine the relative effect of manipulation and core rehabilitation in sedentary patients suffering from acute mechanical low back pain in terms of subjective findings, objective findings and to determine any correlations between these findings Thirty-two participants, with acute low back pain participated in the study. They received treatment over a period of three weeks, two treatments in the first week, two treatments in the second week and a follow up seven days later. Group A received a spinal manipulation while Group B received core rehabilitation exercises. Readings were taken at three time points, namely visit one, three and five before the treatment, they included the following readings: Numerical Pain Rating Scale, Algometer, Roland Morris Low Back Pain and Disability Questionnaire, Biofeedback Stabiliser and the Surface EMG. The results showed that there was no differential (p<0.05) treatment effect between the two Groups, and that both Groups showed a clinical improvement in their low back pain. In conclusion, it appears that even though both these treatment protocols have very different mechanisms of action, both can be effective treatment protocols and that core rehabilitation exercises when properly performed are as effective as manipulation in the treatment of acute low back pain.
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Hicklin, John Renshaw. "The effectiveness of Leander traction versus Static linear traction on chronic facet syndrome patients : a randomised clinical trial." Thesis, 2010. http://hdl.handle.net/10321/524.

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Dissertation in partial compliance with requirements for the Masters Degree in Technology: Chiropractic, Durban University of Technology, 2010.
The aim of this study was establish if Leander versus Static traction was useful for the treatment of facet syndrome, a common type of mechanical lower back pain seen by chiropractors. Two groups of fifteen participants were chosen on the basis of the inclusion and exclusion criteria. The first objective was to determine if Static linear traction was effective for the treatment of lumbar facet syndrome in terms of subjective and objective findings. The second objective was to determine if Leander traction was effective for the treatment of lumbar facet syndrome in terms of subjective and objective clinical findings. Lastly the third objective was to compare the subjective and objective clinical findings for both groups. Design: A randomised, two group parallel controlled clinical trial was carried out between the two sample groups. Participants had to have had chronic lower back pain (> 3months). Thirty symptomatic volunteer participants between 25 and 55 were randomly divided into two equal groups – group A (Leander traction) received 5 treatments over a 2 week period. Similarly, group B (Static linear traction) also received 5 treatments over a 2 week period. Algometer readings, Numerical Pain Rating Scale (NRS101), Pain Severity Scale (PSS) and Oswestery Disabilty Index (ODI) were used as v assessment tools. Subjective and objective clinical findings were taken on the first and second visits (i.e. 48 hours) prior to treatment and immediately after treatment. Another set of subjective and objective readings were taken one week after the fifth treatment in order to gauge the long term effects of both treatments. No treatment was given on the sixth visit. Pressure tolerance measurements using an algometer were taken at the end ranges of motion in Kemp’s test and spinal extension. Outcome measures: SPSS version 15 (SPSS Inc., Chicago, Illinois, USA) was used for statistical analysis of data. A p value of <0.05 was considered as statistically significant. The two groups were compared at baseline in terms of demographics variables and location using Pearson’s chi square tests and ttests as appropriate. Intra-group comparisons were made between all time points. A significant time effect indicated successful treatment intervention. Inter-group comparisons were achieved using repeated measures ANOVA tests for each outcome measured separately. A significant time group interaction effect indicated a significant treatment effect. Profile plots were used to assess the trend and direction of the treatment effect. Results: The results of the study showed that Leander traction and Static linear traction were both effective for treating chronic lumbar facet syndrome and no statistically significant difference was found between subjective and objective clinical findings between the two groups.
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Coetzee, Natasha. "The effect of the activator adjusting instrument in the treatment of chronic sacroiliac joint syndrome." Thesis, 2014. http://hdl.handle.net/10321/1001.

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Objective : Low back pain (LBP), and in particular sacroiliac joint syndrome, is a significant health concern for both patient and their chiropractor with regards to quality of life and work related musculoskeletal disorders. Therefore, chiropractors often utilise mechanical aids to reduce the impact on the chiropractor’s health. It is, however, important to establish whether these mechanical aids are indeed clinically effective, therefore, this study evaluated the Activator Adjusting Instrument (AAI) against an AAI placebo to determine whether this adjusting instrument is an effective aid for both the chiropractor and the patient. Method : This randomised, placebo controlled clinical trial consisted of 40 patients (20 per group), screened by stringent inclusion criteria assessed through a telephonic and clinical assessment screen. Post receipt of informed consent from the patients, measurements (NRS, Revised Oswestry Disability Questionnaire, algometer) were taken at baseline, prior to consultation three and at the follow consultation. This procedure occurred with four interventions over a two week period. Results: The AAI group showed clinical significance for all clinical measures as compared to the AAI placebo group which attained clinical significance only for the Revised Oswestry Disability Questionnaire. By comparison there was only a statistically significant difference between the groups in terms of the algometer readings (p= 0.037). Conclusion : Therefore, it is evident that the AAI seems to have clinical benefit beyond a placebo. However this is not reflected in the statistical analysis. It is, therefore, suggested that this study be repeated with a larger sample size in order to verify the effect on the statistical analysis outcomes.
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Mohamed, Tarek. "Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease." Thesis, 2011. http://hdl.handle.net/10012/6183.

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Alzheimer’s disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). AD pathology is derived from the cholinergic, amyloid and tau hypotheses, respectively. Current pharmacotherapy with known anti-cholinesterases, such as Aricept ® and Exelon ®, only offer symptomatic relief without any disease-modifying effects (DMEs). It is now clear that in order to prevent the rapid progression of AD, new therapeutic treatments should target multiple AD pathways as opposed to the traditional “one drug, one target” approach. This research project employed medicinal chemistry tools to develop multifunctional small organic molecules against three key targets of AD pathology – the cholinesterases (AChE and BuChE), AChE-induced and self-induced Aβ1-40 aggregation and generation (β-secretase). A chemical library composed of 112 derivatives was generated to gather structure-activity relationship (SAR) data. The derivatives were based on a novel, non-fused, 2,4-disubstituted pyrimidine ring (2,4-DPR) template with substituents at the C-2 and C-4 position varying in size, steric and electronic properties. Molecular modeling was utilized to investigate their binding modes within the target enzymes and along with the acquired SAR, the chemical library was screened to identify lead multifunctional candidates.
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Books on the topic "Back – Diseases – Treatment"

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C, Nwuga Vincent, ed. Manual treatment of back pain. Malabar, Fla: Krieger, 1986.

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D, Henson Frances M., ed. Equine back pathology: Diagnosis and treatment. Chichester, West Sussex: Blackwell, 2009.

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Stabholz, Ludvig M. Low back disorders: Innovative ambulatory treatment, self-treatment, and prophylaxis. New York: Vantage Press, 1992.

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Healing back: A practical approach to healing common back ailments. London: Collins & Brown, 2008.

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Cure for lower back pain. Orange, Calif: Abundant Health, 2008.

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Bloom, Gary M. As well as nature intended: The way back. Wilton Manors, Fla: ASA Pub., 2005.

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Border, Peter. Diseases fighting back: The growing resistance of TB and other bacterial diseases to treatment. London: Parliamentary Office of Science and Technology, 1994.

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E, Gelb Daniel, and Jarvis Sarah, eds. The back bible. White Plains, NY: Reader's Digest Association, 2012.

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Back in action. London: Bantam, 1986.

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Lawrence, Lindner, ed. Strong women, strong backs: Everything you need to know to prevent, treat, and beat back pain. New York: G.P. Putnam's Sons, 2006.

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Book chapters on the topic "Back – Diseases – Treatment"

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Guyer, Richard D., and Donna D. Ohnmeiss. "How Disc Replacement Fits in the Treatment Algorithm for Degenerative Disc Disease: Refining Indications for Disc Replacement." In Surgery for Low Back Pain, 177–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-04547-9_25.

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Mehta, Neel D., and Rohit Aiyer. "Dorsal Root Ganglion and Peripheral Nerve Stimulation in the Treatment of Low Back and Leg Pain." In Treatment of Spine Disease in the Elderly, 455–59. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-12612-3_29.

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Foster, Stephanie L., Cristina Kendall, Allia K. Lindsay, Alison C. Ziesel, Rachael S. Allen, Sheree S. Mosley, Esther S. Kim, et al. "Development of Bile Acids as Anti-Apoptotic and Neuroprotective Agents in Treatment of Ocular Disease." In Drug Product Development for the Back of the Eye, 565–76. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9920-7_22.

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Kirchner, F., and E. Anitua. "Minimally Invasive PRGF Treatment for Low Back Pain and Degenerative Disc Disease." In Platelet Rich Plasma in Orthopaedics and Sports Medicine, 259–75. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-63730-3_15.

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Fonseca, Leonardo, Paula Voloch, and Flvio Cavallari. "Nonfusion Techniques for Degenerative Lumbar Diseases Treatment." In Low Back Pain Pathogenesis and Treatment. InTech, 2012. http://dx.doi.org/10.5772/35057.

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Saad, Bashar. "Prevention and Treatment of Obesity-Related Cardiovascular Diseases by Diet and Medicinal Plants." In Herbal Medicine Back to the Future, 125–77. BENTHAM SCIENCE PUBLISHERS, 2019. http://dx.doi.org/10.2174/9789811403743119020005.

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Bozyel, Mustafa Eray, Elif Merdamert Bozyel, and Kerem Canli. "Turkish Herbal Medicine in the Treatment of Back Pain." In Advances in Medical Diagnosis, Treatment, and Care, 235–51. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1320-0.ch012.

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The number of plants used for treatments has been steadily increasing since ancient times. There were around 250 herbal drugs used during the Mesopotamian civilization. During the time of the Greeks, 60 medicinal plants were known. During the Arab-Persian civilization, this number increased to about 4,000. At the beginning of the 19th century, the number of known medicinal plants reached 13,000. These herbal drugs are used to treat many diseases, from diabetes to cancer. Back pain and related symptoms rank as the second most common affliction of humankind. One of the proposed methods to control and treat back pain symptoms is traditional folk medicine. This chapter examines the recent ethnobotanical studies to form a compilation on medicinal plants used as Turkish herbal medicine in the treatment of back pain and their local names, parts, and usage forms.
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Omobolanle Adesanya, Enitan, and Akingbolabo Daniel Ogunlakin. "Potential Use of African Botanicals and Other Compounds in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections." In Infectious Diseases. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108351.

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Infections caused by the group of Staphylococcus bacteria are commonly called Staph infections, and over 30 types of Staphylococcal bacteria exist with Staphylococcus aureus causing about 90% of the infections from the genus. Staphylococcus aureus (S. aureus) is a major cause of both hospital- and community-acquired infections with major concern arising from its strain of species that is resistant to many antibiotics. One of such strain is the Methicillin-resistant Staphylococcus aureus (MRSA) that has been described to be a resistance to methicillin drugs. Another is glycopeptides-resistant emerging from the increased use of glycopeptides drugs. This continuous emergence and spread of new resistant strains of S. aureus is a major challenge which makes the search for novel anti-resistant agents imperative. The development of vaccines from natural and synthetic products is some of the measures being proposed for the protection against the infections. Also, the development of monoclonal or polyclonal antibodies for passive immunization is sought for, and attentions with regard to arriving at successful trials have been directed back to medicinal plant research as an alternative. This review discusses the treatment strategies of MRSA, the antibacterial property of various medicinal plants, and the influence of their active compounds on methicillin-resistant S. aureus (MRSA), as well as to recommend the path to future research in this area.
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Cerrone, Marina, Morten Schak Nielsen, and Mario Delmar. "Genetically modified animals as tools to personalize the study of arrhythmia mechanisms and treatment." In ESC CardioMed, edited by Paulus Kirchhof, 3001–3. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0727.

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Animal research has been fundamental to the progress of basic and applied biomedical sciences. The combination of genetic engineering with new information on the molecular understanding of diseases has provided a strong framework on which to advance personalized cardiovascular medicine. This chapter uses three inheritable diseases (catecholaminergic polymorphic ventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy, and oculodentodigital dysplasia) to demonstrate how animal models have served (or have failed to serve) as surrogates of disease and in doing so, have permitted research that can translate back to the patient.
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"Rabbit diseases and health problems." In Rabbit production, 131–64. 10th ed. Wallingford: CABI, 2022. http://dx.doi.org/10.1079/9781789249811.0010.

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Abstract The aetiology, clinical signs, pathology, diagnosis, treatment, prevention and control of pasteurellosis, rhinitis, pneumonia, abscesses, metritis, orchitis, wry neck, conjunctivitis, enteritis, enterotoxaemia, coccidiosis, Tyzzer's disease, mastitis, bordetellosis, broken back, congenital glaucoma, cannibalism, colibacillosis, dystocia, ear mites, encephalitozooonosis, fibroma, heat prostration, hepatitis E, hutch burn, listeriosis, malocculsion, mange, moist dermatitis, myxomatosis, necrobacillosis, papilloma, pinworms, nest box death, pregnancy toxaemia, pseudotuberculosis, haemorrhagic disease, rabbit pox, syphilis, red urine, ringworm, salmonellosis, sore hocks, splay leg, staphylococcosis, tapeworms, toxoplasmosis, trichobezoar, tularaemia, urolithiasis, uterine adenocarcinoma, vitaminA deficiency and young doe syndrome in rabbits.
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Conference papers on the topic "Back – Diseases – Treatment"

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Cowan, Troy. "Healthcare acquired infection (HAIs): a deadly problem that is preventable: UV can help, what’s holding it back?" In Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases, edited by Tianhong Dai. SPIE, 2018. http://dx.doi.org/10.1117/12.2288584.

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Haentzschel, H., S. Schwalen, J. Kraemer, and T. Theodoridis. "FRI0239 Pain therapy of failed back surgery syndrome patients (fbss): successful long-term treatment with fentanyl tts." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.543.

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Oesch, PR, JP Kool, S. Bachmann, O. Knüsel, R. de Bie, and P. van den Brandt. "SP0131 Conservative treatment for improving working activity in subacute and chronic low back pain-a meta analysys." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.1289.

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Muklason, Ahmad, Faza Rashif, Edwin Riksakomara, Faizal Mahananto, Raras Tyasnurita, Retno A. Vinarti, and Naufal Rafiawan Basara. "Android-Based Chatbot Application Using Back Propagation Neural Network to Help the First Treatment of Children’s Diseases." In SIET '22: 7th International Conference on Sustainable Information Engineering and Technology 2022. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3568231.3568235.

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Sopajareeya, Chuliporn. "Assessment of Risk Factors of Low Back Pain Among Hospital Nurses." In Applied Human Factors and Ergonomics Conference. AHFE International, 2021. http://dx.doi.org/10.54941/ahfe100473.

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Nursing is an occupation with high prevalence of low back pain (LBP). This pain is multifactorial and assessing its risk factors is essential. The study aim was to determine the prevalence and risk factors of LBP among 225 hospital nurses in Thailand in a cross-sectional study. A self-reported questionnaire divided into six parts including personal factors, working factors, job stress modified from the Nursing Stress Scale, low back pain modified from the Standardized Nordic Questionnaire, health behaviors, and work environment was used for collecting the data. Data were analyzed by descriptive statistics and logistic regression. Study results revealed that the prevalence of LBP in the past seven days was 34.2%. Logistic regression analysis indicated that lifting overweight patients without assistance (OR=1.8; 95%CI=0.95-3.77) and having previous diseases related to LBP (OR=6.3; 95%CI=1.65-24.32) were important risk factors of LBP. Study findings are useful for developing LBP preventive strategies including training on lifting and transferring overweight patients by using a lift team method and lifting devices, developing a manual or guidelines for safe patient handling, and treatment of LBP.
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Damasceno Júnior, Eustáquio Costa, Isabella Sabião Borges, João Victor Aguiar Moreira, Pedro Otávio Rego de Aguiar, Thaciany Soares Ferreira, Leonardo Peixoto Garcia, Glauber Mota Pacheco, et al. "Successful treatment with rituximab in a refractory Stiffperson syndrome (SPS)." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.507.

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Background: SPS is a disorder consisting of rigidity of axial muscles with painful spasms. More than 80 % of SPS patients have high titer antibodies against glutamic acid decarboxylase (GAD). The use of rituximab for the treatment of SPS is a recent therapeutical approach showing promising results. We present a case of SPS treated with rituximab, showing a good and safe response. Case: A 38-year-old female patient presented with a history of rigidity of abdominal and paravertebral muscles associated with painful spasms in lower back region, increased tonus, lumbar lordosis, frequent falls and severe functional limitation. The anti-GAD antibodies were positive in high titles. Electromyography showed continuous motor activity with normal morphology especially on paravertebral muscles. She had a partial response to baclofen and diazepam, but could not tolerate it because of somnolence, and started the treatment with rituximab. After one year, the baclofen was discontinued and the diazepam reduced. The axial stiffness and spasm frequency improved, including postural instability, without new episodes of falls. Discussion: Rituximab is a monoclonal antibody targeting the CD20 antigens on the surface of mature B lymphocytes. After binding to these antigens, it initiates a cascade of biochemical events leading to apoptosis. Its use has been approved for numerous diseases with promising results. The use of rituximab in the treatment of SPS is a recent approach and good results have been reported. Conclusion: Rituximab may be a promising option in SPS treatment. However, this is a preliminary paper showing partial results requiring long-term follow-up.
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Moreira, Larissa Iulle, Anderson Bessa da Costa, Nivio Ziviani, Manoel Jacobsen Teixeira, Jefferson Rosi Jr, Marcelo Nishio, Daniella Castro Araujo, Adriano Veloso, and Daniel Ciampi de Andrade. "An artificial intelligence solution to detect and manage non-response to chronic-pain treatment." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.745.

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Chronic Pain (CP) affects one in five people in developing countries, and is the most frequent reason motivating medical visits. Some CP types rank as the most common symptomatic diseases affecting humans worldwide (eg, tension-type headache), and the most common cause of years lived with disability (eg, low back pain). Despite the high costs related to the diagnosis and management of CP, up to 40% of patients remain symptomatic despite best medical therapy. The relative inefficiency of CP management stems from several causes, lack of good predictors of response to treatment being one of them. Inefficient prognostication leads to low response to treatment, high odds of side-effect and iatrogeny, especially in CP syndromes where lesion to somatic or neural tissues are not the driving mechanisms leading to pain (primary headaches, low-back pain, fibromyalgia). We have developed an electronic medical record system specific for pain management and used it in 611 prospective patients addressed to our Institution. We then used structured and unstructured data from the first visit and used as an end-point of good outcome the two higher strata of the patients’ Global Impression of Change score (very much and much improved) systematically collected at the last visit, which took place within 12 months from the first. By using state of art AI algorithms in an interpretable approach, we obtained a list of 12 highly predictable variables, which included pain in specific pain areas of the body, sex, pain pattern and temporal profile. Using these variables, and their complex relationship, we developed a machine learning model that predicted a good long-term outcome at the moment of the first visit, yielding a sensitivity and specificity of 0.69 and 0.73, respectively, with an area under the curve of 0.71. When imputed with variables from the second visit, AUC numbers reached 0.85. Business Model: given the challenges that health systems around the world are facing, the main target today is to make the shift from a payper-use mode to a value-based approach. This will bring the patient to the center of medical decisions. Chronic pain is an ideal scenario to test new strategies directed to these goals. In fact, our strategy allowed the identification of patients who would not respond to traditional therapeutic approaches before they were implemented, potentially saving time, resources and mitigating suffering. Public health systems and integrated health operators can be greatly benefited using this tool by increasing treatment effectiveness and reducing losses. Lower costs for all enables more people to access good health faster. Market share: large health conglomerates with closed loops of care including diagnostic and health-care provider facilities using electronic data record systems.
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Basnolli, Adelina, and Hasan Cana. "A novel sensor-based architecture using 5G and Blockchain for remote and continuous health monitoring." In The 18th international symposium on health information management research. Linnaeus University Press, 2022. http://dx.doi.org/10.15626/ishimr.2020.11.

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The healthcare sector strives to improve the quality of care delivered to patients, especially considering new digital technologies, such as sensor-based networks (SBN). The application of SBN can help to provide remote and continuous monitoring for patients that need continuous treatment and management. In this context, this research proposed a novel sensor-based architecture for healthcare monitoring including 5G as a recent technology for low latency data communication. Blockchain is another component that is integrated to prevent forgery, tampering and enable more secure transmission. Furthermore, this study proposed a unique data architecture that is based on a new protocol that aims to transmit gathered sensor data over existing network architecture (for example, routers) without the need for intermediate devices such as mobile phones, PDAs or tablets. The proposed data architecture is discussed for its application in healthcare through two case scenarios, continuous monitoring of chronic diseases and back pain.
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Casanova, Fernando, and Malisa Sarntinoranont. "Influence of Compressive Pre-Stress on Backflow During Convection Enhanced Delivery in Hydrogel Tissue Phantoms." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80721.

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Convection enhance delivery (CED) is a local drug delivery technique for the treatment of neurological diseases. With CED, a needle (or cannula) is implanted into tissue and either a constant flow rate or pressure is applied to deliver infusate directly into the extracellular space. Under certain conditions, infusate flows back along the outer cannula wall in the space between the cannula and tissue instead of spreading out into tissue. Higher driving fluid pressures are often needed during CED and this can frequently result in backflow especially at high flow rates or with large needle diameters. Backflow is normally undesirable because specific targeting is not achieved, and drugs can reach regions of the brain where they are not effective, toxic, or result in unintended side effects. Previous models have been developed to predict backflow [1,2] that consider elastic expansion of tissue surrounding the needle due to infusion pressure. However compressive pre-stress between the tissue and the needle wall produced by tissues displaced during needle insertion has not been previously considered.
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Pfeiffer, Ferris M., and Dennis L. Abernathie. "The Influence of Facet Fusion Strength on Instrumented Segment Range of Motion." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38082.

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Spinal fusion surgery is one of the most common surgical procedures used to alleviate lower back pain. It is estimated that between 200,000 and 300,000 spine fusion procedures performed each year in the United States [1]. There has been an increase of approximately 8% per year in the frequency of lumbar fusions in the United States since 1980 [2]. Spinal fusion is indicated for treatment of degenerative disk disease, degenerative joint disease, scoliosis, and isthmic and degenerative spondlylotisthesis when more conservative treatments have failed to achieve relief.
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Reports on the topic "Back – Diseases – Treatment"

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Chou, Roger, Jesse Wagner, Azrah Y. Ahmed, Ian Blazina, Erika Brodt, David I. Buckley, Tamara P. Cheney, et al. Treatments for Acute Pain: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), December 2020. http://dx.doi.org/10.23970/ahrqepccer240.

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Objectives. To evaluate the effectiveness and comparative effectiveness of opioid, nonopioid pharmacologic, and nonpharmacologic therapy in patients with specific types of acute pain, including effects on pain, function, quality of life, adverse events, and long-term use of opioids. Data sources. Electronic databases (Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews) to August 2020, reference lists, and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) of outpatient therapies for eight acute pain conditions: low back pain, neck pain, other musculoskeletal pain, neuropathic pain, postoperative pain following discharge, dental pain (surgical or nonsurgical), pain due to kidney stones, and pain due to sickle cell disease. Meta-analyses were conducted on pharmacologic therapy for dental pain and kidney stone pain, and likelihood of repeat or rescue medication use and adverse events. The magnitude of effects was classified as small, moderate, or large using previously defined criteria, and strength of evidence was assessed. Results. One hundred eighty-three RCTs on the comparative effectiveness of therapies for acute pain were included. Opioid therapy was probably less effective than nonsteroidal anti-inflammatory drugs (NSAIDs) for surgical dental pain and kidney stones, and might be similarly effective as NSAIDs for low back pain. Opioids and NSAIDs were more effective than acetaminophen for surgical dental pain, but opioids were less effective than acetaminophen for kidney stone pain. For postoperative pain, opioids were associated with increased likelihood of repeat or rescue analgesic use, but effects on pain intensity were inconsistent. Being prescribed an opioid for acute low back pain or postoperative pain was associated with increased likelihood of use of opioids at long-term followup versus not being prescribed, based on observational studies. Heat therapy was probably effective for acute low back pain, spinal manipulation might be effective for acute back pain with radiculopathy, acupressure might be effective for acute musculoskeletal pain, an opioid might be effective for acute neuropathic pain, massage might be effective for some types of postoperative pain, and a cervical collar or exercise might be effective for acute neck pain with radiculopathy. Most studies had methodological limitations. Effect sizes were primarily small to moderate for pain, the most commonly evaluated outcome. Opioids were associated with increased risk of short-term adverse events versus NSAIDs or acetaminophen, including any adverse event, nausea, dizziness, and somnolence. Serious adverse events were uncommon for all interventions, but studies were not designed to assess risk of overdose, opioid use disorder, or long-term harms. Evidence on how benefits or harms varied in subgroups was lacking. Conclusions. Opioid therapy was associated with decreased or similar effectiveness as an NSAID for some acute pain conditions, but with increased risk of short-term adverse events. Evidence on nonpharmacological therapies was limited, but heat therapy, spinal manipulation, massage, acupuncture, acupressure, a cervical collar, and exercise were effective for specific acute pain conditions. Research is needed to determine the comparative effectiveness of therapies for sickle cell pain, acute neuropathic pain, neck pain, and management of postoperative pain following discharge; effects of therapies for acute pain on non-pain outcomes; effects of therapies on long-term outcomes, including long-term opioid use; and how benefits and harms of therapies vary in subgroups.
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Covid-19 and Water in Asia and the Pacific: Guidance Note. Asian Development Bank, July 2021. http://dx.doi.org/10.22617/tim210265.

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The coronavirus disease (COVID-19) pandemic has had a wide-ranging and substantial impact on the water sector in Asia and the Pacific. This guidance note focuses on how service providers—particular those involved in supply, sanitation, and wastewater treatment—have been affected and the response measures they have undertaken. It also identifies potential pathways to shape a post-pandemic recovery for the sector and the role of the Asian Development Bank (ADB) in supporting this. The guidance note is one of a series produced by ADB for key sectors and thematic areas.
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