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1

U, Gerbershagen H., Zimmermann M. 1933-, and World Congress on Pain. (5th : 1987 : Hamburg, Germany), eds. B-vitamins in pain: Hamburg, 2nd August 1987. Frankfurt am Main: PMI Verlag, 1988.

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2

Food and Agriculture Organization of the United Nations. and World Health Organization, eds. Requirements of vitamin A, iron, folate, and vitamin B12: Report of a joint FAO/WHO expert consultation. Rome: Food and Agriculture Organization of the United Nations, 1988.

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3

Victor, Herbert, ed. Vitamin B12 deficiency. London: Royal Society of Medicine Press, 1999.

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4

Ruma, Banerjee, ed. Chemistry and biochemistry of B12. New York: Wiley, 1999.

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5

European Symposium on Vitamin B12 and B12-Proteins (4th 1996 Innsbruck, Austria). Vitamin B12 and B12-proteins: Lectures presented at the 4th European Symposium on Vitamin B12 and B12-Proteins. Weinheim: Wiley-VCH, 1998.

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6

1939-, Stroiński Andrzej, ed. Comprehensive B12: Chemistry, biochemistry, nutrition, ecology, medicine. Berlin: De Gruyter, 1987.

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7

Aloba, Oladapo Babatunde. Nutritional status of B6 vitamers, vitamin B12 and folate in alcoholic patients. [Guildford]: University of Surrey, 1999.

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8

International Symposium on Biomedicine and Physiology of Vitamin B12. (1st 1988 London, England). Biomedicine and physiology of vitamin B12: Proceedings of the First International Symposium, Charing Cross & Westminster Medical School, University of London, 26-29 September 1988. Edited by Bhatt H. R and Linnell J. C. London: The Children's Medical Charity, 1990.

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9

Waters, Henry McKiness. Vitamin B12: Absorption and binding proteins. Manchester: University of Manchester, 1996.

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10

1965-, Stuart Jeffrey J., ed. Could it be B12?: An epidemic of misdiagnoses. 2nd ed. Fresno, Calif: Quill Driver Books, 2011.

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11

I͡Urkevich, A. M. Struktura, svoĭstva i mekhanizm deĭstvii͡a kobalaminovykh kofermentov. Moskva: VINITI, 1985.

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12

Dahlfors, Agneta A. Richter. Regulation of the cobalamin biosynthetic genes in Salmonella typhimurium. Uppsala: Acta Universitatis Upsaliensis, 1994.

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13

D, Wright Jacqueline, and National Center for Health Statistics (U.S.), eds. Blood folate and vitamin B12: United States, 1988-95. Hyattsville, Md: U.S. Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, 1998.

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14

Babior, Bernard M. Cobalamin: Biochemistry and pathophysiology. New York: J. Wiley & Sons, 1988.

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15

Zöllner, N., H. Fassl, I. Jurna, K. F. Pietrzik, and M. Schattenkirchner, eds. Klinische Bedeutung von Vitamin B1, B6, B12 in der Schmerztherapie. Heidelberg: Steinkopff, 1988. http://dx.doi.org/10.1007/978-3-642-72427-5.

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16

Clegg, Richard. Radiation-chemical studies of some sulphophthalocyanine complexes and vitamin B12. Salford: University of Salford, 1986.

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17

Al-Naieb, Monjed Abdul Baki. Szilard-Chalmers effects in sulphonated metallophthalocyanines, metalloporphyrins and vitamin B12. Salford: University of Salford, 1987.

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18

Myths and facts about human growth hormone, B-12, and other substances: Hearing before the Committee on Oversight and Government Reform, House of Representatives, One Hundred Tenth Congress, second session, February 12, 2008. Washington: U.S. G.P.O., 2009.

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19

Frank, Jordan, and Patel Mulchand S, eds. Thiamine: Catalytic mechanisms in normal and disease states. New York: Marcel Dekker, 2004.

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20

Service, Shell Education, ed. Dorothy Crowfoot Hodgkin: Unravelling the complexities of insulin, penicillin and vitamin B12. London: Shell Education Service, 1994.

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21

Dixon, Ruth Mary. Synthesis and reactions of dihyroxyalkycobalamins: A model for vitamin B12-dependent propanediol dehydratase. [s.l.]: typescript, 1985.

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22

Obeid, Rima. Vitamin B12: Advances and Insights. Taylor & Francis Group, 2017.

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23

Obeid, Rima. Vitamin B12. Taylor & Francis Group, 2021.

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24

Obeid, Rima. Vitamin B12: Advances and Insights. Taylor & Francis Group, 2017.

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25

Obeid, Rima. Vitamin B12: Advances and Insights. Taylor & Francis Group, 2017.

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26

Obeid, Rima. Vitamin B12: Advances and Insights. Taylor & Francis Group, 2017.

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27

Vitamin B12: Advances and Insights. Taylor & Francis Group, 2017.

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28

Cone, Clark A., and Michael J. McHale. Litigating Tmj Cases, 1994 Supplement. Wiley Law Pubns, 1994.

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29

Misulis, Karl E., and E. Lee Murray. Nutritional Deficiencies and Toxicities. Edited by Karl E. Misulis and E. Lee Murray. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190259419.003.0029.

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Nutritional disorders are often encountered in hospital neurology practice, especially deficiencies of vitamins B1 and B12. Medical conditions can predispose to nutritional disorders. This chapter discusses the presentation, diagnosis, and management of B12 deficiency, B1 deficiency, protein-energy malnutrition, folate deficiency especially in the context of pregnancy, B6 deficiency, B6 toxicity, copper deficiency, and vitamin D deficiency. Wernicke encephalopathy and Korsakoff syndrome are also discussed.
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30

Silva, Aminda De, J. A. Saunders, and M. A. Stroud. Vitamin deficiencies. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0333.

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Vitamins are organic compounds required by the body in small amounts to perform specific cellular functions. Nine vitamins (thiamine (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), niacin (nicotinic acid; vitamin B3), pantothenic acid (vitamin B5), biotin (vitamin B7; vitamin H), folic acid (folate; vitamin B9), and ascorbic acid (vitamin C)) are water soluble, while four (vitamins A, D, E, and K) are fat soluble. The importance of vitamins was first appreciated through recognition of their clinical deficiency state. However, this approach has led to the concept that the primary purpose of a vitamin is to prevent the associated clinical deficiency state and, consequently, unless patients exhibit signs of a specific clinical deficiency state, they are thought to be replete in the corresponding vitamin. This is a misunderstanding. In reality, most vitamins have many different functions which are incompletely understood, and impaired biochemical function and even functional problems affecting metabolic, immunological, or cognitive status can occur with marginal vitamin depletion long before overt clinical deficiency becomes evident. A high index of suspicion is thus essential in all patients who have malnutrition or malabsorption, to ensure that levels that might compromise health, resistance to disease, and recovery from injury or illness are not left untreated.
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31

Biosynthesis: Polyketides and Vitamins (Springer Desktop Editions in Chemistry). Springer, 2000.

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32

Black, Michael. Vitamins Soluble in Water : (b1, B2, B3, B5, B6, B9, B12, C, H). Independently Published, 2019.

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33

Krautler, Bernhard. Vitamin B12 and B12-Proteins. Wiley-VCH Verlag GmbH, 1998.

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34

Vitamin B12. Elsevier, 2022. http://dx.doi.org/10.1016/s0083-6729(22)x0003-4.

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35

Kräutler, B., D. Arigoni, and B. T. Golding, eds. Vitamin B12 and B12‐Proteins. Wiley, 1998. http://dx.doi.org/10.1002/9783527612192.

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36

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Guidelines for the pre-conception period. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0036.

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Where possible, pre-conception counselling is desirable for both prospective parents in order to address issues of lifestyle and nutrition so that pregnancy can proceed with the best possible start. If dieting is necessary this should be initiated as far in advance of the pregnancy as possible, because inadequate nutrition around the time of conception can influence the fetal growth trajectory and weight at birth. Regardless of BMI, women should also be encouraged to engage in regular aerobic exercise. Nutritional requirements in the pre-conception period include adequate amounts of oily fish to provide omega-3 fatty acids. All women planning a pregnancy should receive 400 #amp;#x00B5;g of folic acid daily, and vitamin B12 and vitamin D supplementation may be necessary, particular for vegetarians. Other vitamins and minerals should be considered, particularly iron and iodine, but most should be obtainable from a balanced diet. Harmful behaviours and environmental exposures should be avoided.
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37

Pacholok, Sally M. La vitamina B12. 2017.

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38

Gebhardt, Sarah. Vitamin B12: Der Praktische Leitfaden. Independently Published, 2020.

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39

FAQs: All about B Vitamins (Frequently Asked Questions). Avery, 1998.

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40

Schneider, Zenon, and Andrzej Stroinski. Comprehensive B12: Chemistry, Biochemistry, Nutrition, Ecology, Medicine. de Gruyter GmbH, Walter, 2011.

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41

Linnell, J. C. Biomedicine and Physiology of Vitamin B12, Proceedings of the First International Symposium, Charing Cross & Westminster Medical School, University of London, 26 - 29 September 1988. The Children's Medical Charity 1990., 1990.

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42

Schneider, Zenon, and Andrzej Stroinski. Comprehensive B12: Chemistry, Biochemistry, Nutrition, Ecology, Medicine. de Gruyter GmbH, Walter, 1987.

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43

C, Linnell J., Bhatt H. R, and Children's Medical Charity, eds. Biomedicine and physiology of vitamin B12. Children's Medical Charity, 1989.

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44

Vitamin B12: Chemical Aspects, Transport, Cause and Symptoms of Deficiency, Dietary Sources and Health Benefits. Nova Science Publishers, Incorporated, 2015.

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45

Kelvin, Matelong. Vitamin B12 Vegan Sources: We Don't Have to Eat Animal Products to Get Vitamin B12. Independently Published, 2017.

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46

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B12 (cobalamin) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0013.

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Vitamin B12 is required for the synthesis of fatty acids and myelin and so is crucial for normal neurological function and maintenance of the CNS. In conjunction with folate, it is involved in red blood cell formation and DNA synthesis, and in embryogenesis, it is important for proper neural tube formation and brain development. Maternal intake during pregnancy is important, as only newly absorbed vitamin B12, and not that stored in the maternal liver, is concentrated in the placenta. Despite the active transfer during pregnancy, the vitamin B12 content in the newborn is low, and the infant is dependent on breast milk for ongoing needs. Pregnant and lactating women should ensure that their diet contains sufficient (animal) sources of vitamin B12; those consuming vegan or strict vegetarian diets should either take vitamin B12 supplements or seek foods that have been fortified with vitamin B12.
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47

Govender, Penny, Francis Opoku, Olaide Wahab, and Ephraim Kiarii. Molecular Modelling of Vitamin B12 and Its Analogues. Jenny Stanford Publishing, 2021.

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48

Molecular Modelling of Vitamin B12 and Its Analogues. Jenny Stanford Publishing, 2021.

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49

Govender, Penny, Francis Opoku, Olaide Wahab, and Ephraim Kiarii. Molecular Modelling of Vitamin B12 and Its Analogues. Jenny Stanford Publishing, 2021.

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50

Govender, Penny, Francis Opoku, Olaide Wahab, and Ephraim Kiarii. Molecular Modelling of Vitamin B12 and Its Analogues. Taylor & Francis Group, 2021.

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