Log in

Relevant bibliographies by topics / B-cell malignancie / Dissertations / Theses

To see the other types of publications on this topic, follow the link: B-cell malignancie.

Dissertations / Theses on the topic 'B-cell malignancie'

Author: Grafiati

Published: 1 April 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'B-cell malignancie.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

BOZZER, SARA. "Preclinical development of targeted-nanoparticles for the treatment of pediatric B-cell malignancies Acute Lymphoblastic Leukemia and Burkitt Lymphoma." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3030999.

Full text

Abstract:

I tumori delle cellule B sono un gruppo eterogeneo di patologie per le quali le opzioni terapeutiche includono chemioterapia e immunoterapia. Nonostante il recente sviluppo di nuove strategie terapeutiche, la maggior parte dei pazienti, tuttavia, sviluppa resistenze o non risponde alle terapie. L'obiettivo di questo progetto di dottorato è, pertanto, lo sviluppo preclinico di un nuovo strumento terapeutico per il trattamento delle neoplasie pediatriche a cellule B. In primo luogo sono state caratterizzate le nanobolle di chitosano (NBs) caricate con AntagomiR-17, sui è stato legato un anticorp

APA, Harvard, Vancouver, ISO, and other styles

2

Runarsson, Gudmundur. "Biosynthesis of leukotriene B₄ in hematological malignancies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-386-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Green, Michael R. "Molecular Profiling of B-Cell Malignancies." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/366546.

Full text

Abstract:

Non-Hodgkin’s lymphoma (NHL) is a group of B-cell malignancies that is the 5th most common cancer in males and the 4th most common cancer in females. Three of the four most common histological subtypes of NHL are Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL) and B-cell Chronic Lymphocytic Leukemia (B-CLL), which together make up over 60% of NHL cases. These diseases vary in both aetiology and aggressiveness, with patient prognosis predicted using indices that rely on biological surrogates in order to predict disease behavior. This results in a large degree of heterogeneity wi

APA, Harvard, Vancouver, ISO, and other styles

4

Mosti, Laura [Verfasser], and Anton [Akademischer Betreuer] Cathomen. "Generation of safe CAR T cells to target B cell malignancies." Freiburg : Universität, 2021. http://d-nb.info/1232174378/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Kokhaei, Parviz. "Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-595-X/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Martínez-Martín, Sandra. "Targeting MYC in B-cell haematologic malignancies." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670653.

Full text

Abstract:

La importància de la funció de MYC en el càncer (i l’origen del nom de la oncoproteïna) es va descobrir a finals dels 70, amb la identificació de la seqüència del retrovirus aviar causant de la leucèmia mielocítica. Durant més de 40 anys d’investigació, s’ha subratllat la rellevància d’aquesta proteïna en la divisió cel·lular normal i la seva implicació en la transformació tumoral. De fet, una de les primeres connexions entre la sobreexpressió de proto-oncògens (com MYC), reordenaments gènics i el càncer es va fer en el limfoma de Burkitt, la leucèmia mieloide crònica i els plasmacitomes de r

APA, Harvard, Vancouver, ISO, and other styles

7

McCann, Katy. "Immunogenetic analysis of aggressive B-cell malignancies." Thesis, University of Southampton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494386.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Gupta, Sneha Veeraraghavan. "Targeting Protein Metabolism in B-cell Malignancies." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343169973.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Jiménez, Bernal Isabel. "Tumor immune microenvironment in B-cell lymphoid malignancies." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671173.

Full text

Abstract:

El microambient immune tumoral juga un paper fonamental en les etapes inicials de la formació dels tumors i en la progressió d’aquests. Teràpies dirigides a aquest microambient ofereixen noves opcions terapèutiques i també serveixen per a millorar les teràpies actuals enfront de molts càncers, incloent els que afecten les cèl·lules B. No obstant això, són necessàries més recerques per a entendre en major profunditat els mecanismes d’evasió del sistema immune que afavoreixen la progressió dels tumors i dissenyar immunoteràpies més precises. Els nostres principals objectius són aportar noves evi

APA, Harvard, Vancouver, ISO, and other styles

10

Caeser, Rebecca. "Elucidating oncogenic mechanisms in human B cell malignancies." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/285011.

Full text

Abstract:

This study consists of two pieces of work investigating haematological malignancies; Acute Lymphoblastic Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all patients diagnosed with ALL relapse. Activating mutations in the RAS pathway are common (~50%) and result in hyperactivation of the MAPK pathway. I identified Erk negative feedback control via DUSP6 to be crucial for NRASG12D-mediated pre-B cell transformation and investigated its potential as a t

APA, Harvard, Vancouver, ISO, and other styles

11

Forster, Jade. "Evaluating the genomic landscape of B cell malignancis." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/408724/.

Full text

Abstract:

Splenic marginal zone lymphoma (SMZL) and chronic lymphocytic leukaemia (CLL) are B cell malignancies, predominately affecting the elderly. The disease course of both SMZL and CLL is highly variable, with some patients dying rapidly within a month whilst other remain stable and live a normal lifespan. Biomarkers are used to help to distinguish those patients who may progress. Genomic abnormalities such as copy number alterations and mutation of genes may have prognostic value in CLL and SMZL. Several technologies were used to assess the genomic landscape in B cell malignancies; low resolution

APA, Harvard, Vancouver, ISO, and other styles

12

Pocock, Christopher Francis Elliot. "Modelling and molecular manipulation of human B cell malignancies." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261876.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Alcaraz, Amor. "ZFP36 proteins and mRNA targets in B cell malignancies." Thesis, University of Westminster, 2015. https://westminsterresearch.westminster.ac.uk/item/q254z/zfp36-proteins-and-mrna-targets-in-b-cell-malignancies.

Full text

Abstract:

The ZFP36 proteins are a family of post-transcriptional regulator proteins that bind to adenine uridine rich elements (AREs) in 3’ untranslated (3’UTR) regions of mRNAs. The members of the human family, ZFP36L1, ZFP36L2 and ZFP36 are able to degrade mRNAs of important cell regulators that include cytokines, cell signalling proteins and transcriptional factors. This project investigated two proposed targets for the protein family that have important roles in B cell biology, BCL2 and CD38 mRNAs. BCL2 is an anti-apoptotic protein with key roles in cell survival and carcinogenesis; CD38 is a membr

APA, Harvard, Vancouver, ISO, and other styles

14

Lim, Sean H. "Investigation of CD20-directed immunotherapy in B-cell malignancies." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/376893/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Rafiq, Sarwish. "Evaluation of Antibody-based Therapeutics in B cell Malignancies." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338321515.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Karlsson, Hannah. "CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232638.

Full text

Abstract:

Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. T cells expressing these chimeric antigen receptors (CARs) could recognize and specifically kill tumor cells. However the T cells, lacked in persistence and tumor rejection did not occur. Thus, the CAR constructs have been improved by providing the T cell with costimulatory

APA, Harvard, Vancouver, ISO, and other styles

17

Dubosq, Ming-Celine. "The non-viral production of Chimeric Antigen Receptor T-cells for B-cell haematological malignancies." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23170.

Full text

Abstract:

Chimeric antigen receptor (CAR) T-cells are genetically engineered to express a synthetic receptor which redirects their specificity and effector functions to a tumour associated antigen. They have induced unsurpassed clinical responses in patients with relapsed and refractory CD19-positive haematological malignancies who hitherto had limited treatment options. Currently, all commercially available CAR T-cell products are manufactured using viral vectors for transduction, an efficient but highly costly and complex process. Thus, access to CAR T-cell therapy is inequitable. Historically, the

APA, Harvard, Vancouver, ISO, and other styles

18

Mouzakiti, Amalia. "Regulation of death receptor-mediated apoptosis in B cell malignancies." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271649.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Walter, Harriet Sarah. "Studies of Bruton's tyrosine kinase inhibitors in B-cell malignancies." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42887.

Full text

Abstract:

Despite significant advances, the prognosis in relapsed/refractory (R/R) B-cell malignancies remains poor. In the Phase I study of the selective Bruton’s Tyrosine Kinase inhibitor (BTKi) tirabrutinib in R/R B-cell malignancies, I showed that targeting BTK demonstrated remarkable clinical responses and tolerability in Chronic Lymphocytic Leukaemia and Mantle Cell Lymphoma. Targeted DNA sequencing demonstrated that no mutations were associated with a lack of response in CLL. However, in activated B-cell like diffuse large B-cell lymphoma (ABC DLBCL), only 35% of patients responded to treatment a

APA, Harvard, Vancouver, ISO, and other styles

20

SIMONETTI, GIORGIA. "B lymphoid malignancies: insights from mouse models." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/30033.

Full text

Abstract:

Despite several recent advancements in the treatment of B lymphoproliferative disorders, still a considerable number of lymphoma cases either cannot be cured or become incurable when relapsing. This issue reflects the need for better and more effective therapies that can be designed once novel pathogenic mechanisms have been designed and suitable preclinical models have been established. Therefore, aim of this thesis was to understand the molecular mechanisms leading to mature B lymphoid malignancies by using different mouse models, in order to identify novel potential therapeutic targets and

APA, Harvard, Vancouver, ISO, and other styles

21

Brown, Alison G. "Molecular analysis of 13ql4 abnormalities in B-cell malignancy." Thesis, University of Edinburgh, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306244.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Flordal, Thelander Emma. "Genetic characterization of hematological malignancies with focul on mantle cell lymphoma /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-161-6/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Samuel, Jesvin John. "Translational studies in B-cell malignancies : studies on TP53 and BRAF." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/36233.

Full text

Abstract:

This thesis contains two distinct parts: Current models of Chronic Lymphocytic Leukaemia (CLL) pathogenesis invoke specialised anatomical microenvironments that harbour proliferating cells. Such proliferating CLL cells are more resistant to current immuno-chemotherapeutic regimens than cells in the peripheral blood and are thought to be the cause of disease relapse. Using a system to recapitulate CLL proliferation centres in vitro, I have observed that CLL cells undergo proliferation. Unexpectedly, under these conditions an induction of wild-type TP53 protein was also observed in all cases of

APA, Harvard, Vancouver, ISO, and other styles

24

Israelsen, Nathan. "Surface-Enhanced Raman Spectroscopy-Based Biomarker Detection for B-Cell Malignancies." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4605.

Full text

Abstract:

This thesis presents a light scattering-based method for biomarker detection, which could potentially be used for the quantification of multiple biomarkers specific to B-cell malignancies. This method uses fabricated gold nanoparticle probes to amplify inelastic light scattering in a process referred to as surface-enhanced Raman scattering. These gold nanoparticle probes were conjugated to antibodies for specific and targeted molecular binding. The spectrum of the amplified inelastic light scattering was detected using a spectrometer and a detector. To detect the light scattering signal from t

APA, Harvard, Vancouver, ISO, and other styles

25

McWilliams, Emily Mary. "Restoring Innate NK-cell Immunity with Antibody Therapeutics in CLL B-Cell Malignancy." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479863842166353.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Bishop, David C. "Clinical Translation of CD19-Specific Chimeric Antigen Receptor T cells Generated with the piggyBac Transposon System for the Treatment of B Cell Malignancies." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/22305.

Full text

Abstract:

CD19-specific chimeric antigen receptor (CAR19) T cells are effective against relapsed/refractory B cell malignancy; but, most are individualised autologous products that have been generated using viral vectors. The complexity and cost of this approach is a barrier to widespread use. The plasmid-based piggyBac transposon system is a simple and economical alternative to viral vectors for transgene delivery. However, CAR19 T cells previously generated with piggyBac lacked in vivo efficacy, likely due to deleterious interactions of the CAR with other immune cells. This thesis describes the clinic

APA, Harvard, Vancouver, ISO, and other styles

27

McCarthy, Helen. "Immunogenetic analysis of B-cell malignancies and the clinical application of DNA idiotypic vaccines." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418059.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Park, Eugene. "Chemosensitisation of B-cell malignancies through inhibition of microenvironmental Protein Kinase C-beta (PKCβ)". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288230.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Capolla, Sara. "Use of immune-nanoparticles containig chemiotherapeutic agents for the treatment of B-cell malignancies." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/10980.

Full text

Abstract:

2013/2014<br>B-cell malignancies are a heterogeneous group of clinical conditions including indolent diseases such as Chronic Lymphocytic Leukemia (CLL) and highly aggressive lymphoproliferative disorders such as Burkitt’s lymphoma. B-cell malignancies treatments take advantage of dose-intensive chemotherapeutic regimens and immunotherapy via monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents and cause several adverse effects. Thus, we propose a novel therapeutic approach for the treatment of CLL and Burkitt’s lymphoma in which high-do

APA, Harvard, Vancouver, ISO, and other styles

30

Rozmus, Jacob. "Novel mechanisms involving B cell receptor (BCR) and B cell activating factor (BAFF) signaling pathways underlying human primary immunodeficiencies and malignancy." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58377.

Full text

Abstract:

The proper differentiation and survival of human peripheral immature B cells relies on two critical signaling pathways: B cell receptor (BCR) signaling and the B cell activating factor (BAFF)/BAFF-receptor (BAFF-R) signaling axis. The quality of the BCR signal is regulated in a developmental manner. Self-reactive early immature B cells are eliminated in response to strong BCR-induced signals, while late immature B cells require BCR-induced signals for survival and further differentiation. Although components and events downstream of the BCR are well known, the mechanisms of BCR signaling and i

APA, Harvard, Vancouver, ISO, and other styles

31

Lin, Bin Liang Kevin. "The role of the Rap GTPases in B-cell morphology, function, and malignancy." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/9900.

Full text

Abstract:

B-lymphocytes rearrange their cytoskeleton and undergo dramatic morphological changes when searching for antigens and when forming immune synapses upon contacting cells that display antigens on their surface. Although these morphological changes are essential to B cell function, the signaling pathways underlying these processes are not fully understood. The aim of this thesis is to investigate how B cell receptor (BCR) and integrin signaling regulate B cell morphological changes. The Rap GTPases (Rap) are molecular switches that regulate integrin activation, adhesion, migration in B cells a

APA, Harvard, Vancouver, ISO, and other styles

32

Laffan, Michael. "Anomalous gene rearrangements in B-cell malignancies : implications for the mechanism of immunoglobulin class switch." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336094.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Farren, Timothy william. "The role of the NK cell receptor CD160 in the diagnosis, differentiation and function of chronic B-cell malignancies." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9011.

Full text

Abstract:

Chronic Lymphocytic Leukaemia (CLL) remains the most abundant leukaemia in those aged over 65 years. It is characterised by the expansion of malignant monoclonal B-lymphocytes that were originally described as being functionally incompetent. Identified by immunophenotypic expression of monoclonal light chain restriction, it falls into the classification of chronic B-cell lymphoproliferative disorders (B-LPD). This thesis aims to demonstrate that CD160, an activating NK cell receptor, is aberrantly expressed in B-LPD and can function as a tumour specific antigen, which has clear translation rol

APA, Harvard, Vancouver, ISO, and other styles

34

Liu, Hui. "The molecular mechanisms of cyclin D1 gene deregulation by immunoglobulin regulatory sequences in B cell malignancies." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280522.

Full text

Abstract:

Cyclin D1 expression is deregulated by chromosome translocation in mantle cell lymphoma and a subset of multiple myeloma. The epigenetic mechanisms involved in this long-distance gene deregulation were studied. The cyclin D1 promoter was hypomethylated and hyperacetylated in expressing cell lines and patient samples. Domains of hyperacetylated histones and hypomethylated DNA extended over 120 kilobases upstream of the cyclin D1 gene. Interestingly, hypomethylated DNA and hyperacetylated histones were also located at the cyclin D1 promoter but not upstream regions in cyclin D1 nonexpressing, no

APA, Harvard, Vancouver, ISO, and other styles

35

Haga, Christopher L. "Analysis of the role of FCRL5 and FIGLERs in B cell development, signaling and malignancy." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/haga.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Hammarström, Viera. "B-cell immunity in patients with hematological malignancies and after stem cell transplantation : studies with special reference to tetanus and pneumococcal immunity /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980828hamm.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Mani, Rajeswaran. "Preclinical development of a non-immunosuppressive FTY720 derivative OSU-2S forchronic lymphocytic leukemia and other B-cell malignancies." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1404067069.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Willis, Anthony Graham. "Rapid molecular cloning of immunoglobulin translocations in B-cell malignancy by long-distance inverse polymerase chain reaction." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312267.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

PIEVANI, ALICE SILVIA. "Cytokine-induced killer (cik) cell cultures for the adoptive immunotherapy of hematological malignancies: characterization and new therapeutic strategies for clinical application." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20178.

Full text

Abstract:

Cytokine-induced killer (CIK) cells are a heterogeneous population of lymphocytes obtained in vitro within 21 days from mononuclear cells under the influence of cytokines. CIK cells show potent MHC-unrestricted cytotoxicity against a variety of tumor cells, in particular hematological malignancies, and minimal tendency to induce graft-versus-host disease. The expanded bulk CIK culture consists of over 90% CD3+ cells, of which the majority coexpress CD56 and the remaining cells are CD56-. CD3+CD56+ “true” CIK cells are terminally differentiated non dividing lymphocytes which could deliver pote

APA, Harvard, Vancouver, ISO, and other styles

40

Dey, A. "Enhancing the neutrophil-mediated anti-cancer response after oncolytic measles virus therapy in B cell malignancy : dissecting out the mechanism." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1521057/.

Full text

Abstract:

Oncolytic measles virus (MV) is being tested in several ongoing clinical trials with encouraging results. There is a demonstrable need to explore the role of the immune system in addition to the direct oncolytic effect of MV. My laboratory has previously shown that neutrophils are involved in MV-mediated tumour regressions, becoming activated, upon MV infection. This thesis further explores the role of neutrophils, one of the key players of the innate immune system in MV oncolysis. First, I showed that acute lymphoblastic leukaemia (ALL) shows marked sensitivity to MV oncolysis (Patel, Dey et

APA, Harvard, Vancouver, ISO, and other styles

41

Lo, Yee-nga, and 盧懿雅. "Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in mature B-cell malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632505.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Choudhary, Gaurav Sudhakar. "Role of Myeloid Cell Leukemia 1 (MCL-1) in mediating chemoresistance towards BCL-2 homology 3 (BH3) mimetics in lymphoid malignancies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448024862.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Ouedraogo, David Eric. "Exploration du réservoir EBV chez les patients infectés par le VIH : implications pathologiques." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T001.

Full text

Abstract:

Les lymphocytes B mémoires circulants incluant ceux infectés par EBV de façon latente retournent périodiquement vers les territoires lymphoïdes secondaires où ils subissent une différenciation en cellules productrices d'immunoglobulines permettant au virus d'initier la réplication virale. Cependant, le suivi et la gestion de la réactivation de EBV et son association avec des néoplasies lymphoïdes chez les sujets infectés par le VIH restent un sujet de controverse et nécessite une meilleure compréhension des mécanismes impliqués. Dans cette étude, nous avons proposé de nouveaux outils biologiqu

APA, Harvard, Vancouver, ISO, and other styles

44

Zangrossi, Manuela. "Study of the extra-telomeric functions of telomerase in in vitro and in vivo models." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426233.

Full text

Abstract:

Maintenance of telomere length, required for the unlimited cell proliferation displayed by cancer cells, is provided by telomerase, a ribonucleoprotein complex containing a specialized reverse transcriptase, encoded by TERT gene, that uses an internal RNA template to maintain telomeres length, thus playing a critical role in tumor formation and progression. TERT is usually repressed in normal somatic cells, but is detectable in the vast majority of tumors. Recent studies have suggested that TERT, besides maintaining telomere, is involved in other cellular functions, and it may contribute to

APA, Harvard, Vancouver, ISO, and other styles

45

Dandoit, Mylène. "Evaluation de l'impact de la prise en charge thérapeutique sur la survie et la qualité de vie des patients atteints d'un lymphome folliculaire ou d'un lymphome B diffus à grandes cellules." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOS038/document.

Full text

Abstract:

En France, les hémopathies lymphoïdes, se situant au sixième rang des cancers les plus fréquents, sontun problème majeur de santé publique. Ce travail a pour objectif d’étudier l’impact de la prise en charge thérapeutiquesur la survie et sur la qualité de vie (QdV) des patients atteints de ce type d’hémopathies. Le premierobjectif de ce travail est un état des lieux de l’épidémiologie des hémopathies lymphoïdes avec l’étudede l’évolution de l’incidence et de la survie nette en Côte d’Or entre 1980 et 2009. L’incidence, en nette augmentationdepuis 1980, semble se stabiliser depuis les années 20

APA, Harvard, Vancouver, ISO, and other styles

46

Koduri, Megha Pallavi. "The curative potential of chimeric antigen receptor T-cell therapy for B-cell malignancies." Thesis, 2017. https://hdl.handle.net/2144/23818.

Full text

Abstract:

Few cancers arising in fluid organ systems can be cured with localized therapeutic modalities, such as radiation or surgical organ removal. Chemotherapy and hematopoietic stem cell transplants have long been employed as the standard of care for patients diagnosed with leukemias and lymphomas. Though research continues to propose new, more potent chemotherapeutic agents, a new paradigm of treating cancerous malignancies with tumor-specific monoclonal antibodies, adoptively transferred tumor-fighting cells, and other exogenously administered immunomodulatory agents, has emerged over the past dec

APA, Harvard, Vancouver, ISO, and other styles

47

Liu, Hui. "Functional studies of BCL11A a transcriptional repressor implicated in chromosome 2p13-disrupted malignancy /." Thesis, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3099485.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Maswabi, Bokang Calvin. "Charakterizace hematopoetických buněk u pacientů s nádorem ze zralých B buněk." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-372368.

Full text

Abstract:

(English) Using flow cytometry we analyzed absolute and relative proportions of hematopoietic stem and progenitors cells (HSPC) populations including hematopoietic stem cells (HSC), multipotent progenitors (MPP), multilymphoid progenitors (MLP) and pro B cells from bone marrow of patients with mature B cell malignancies and in healthy controls. We found lower absolute and relative numbers of MLP and higher relative numbers of HSC were observed in patients when compared to age-matched controls irrespective of bone marrow (BM) involvement. On the other hand significantly decreased absolute numbe

APA, Harvard, Vancouver, ISO, and other styles

49

Berry, Nadine Kaye. "Clinical use of SNP-microarrays for the detection of genome-wide changes in haematological malignancies with a focus on B-cell neoplasms." Thesis, 2020. http://hdl.handle.net/1959.13/1412536.

Full text

Abstract:

Research Doctorate - Doctor of Philosophy (PhD)<br>Haematological malignancies are a heterogenous group of cancers that originate in the mature or immature cells of the haemopoietic system. Some originate in the bone marrow, where stem cells differentiate into many types of immature blood cells, while others may form in the peripheral blood once the blood cell has matured. Each type of haematological malignancy is usually characterised by a distinct set of genomic changes that, when identified, can be used to make a specific diagnosis, predict response to therapy, provide a risk for relapse or

APA, Harvard, Vancouver, ISO, and other styles

50

Bai, Li-Yuan, and 白禮源. "Treating B-cell lymphoid malignancies with non-conventional chemotherapeutic agents: study of compounds targeting p38 MAPK, Akt pathways or histone deacetylase." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/00407222502301962749.

Full text

Abstract:

博士<br>中國醫藥大學<br>臨床醫學研究所博士班<br>99<br>Hematological malignancies can be grouped as either myeloid or lymphoid disorders. The standard treatment strategy for lymphoid malignancies is chemotherapeutic agents, usually in combination with monoclonal antibodies which have introduced great impact on the clinical situation. Although certain subtypes of lymphoid malignancies, e.g. diffuse large B cell lymphoma, have good response to initial treatment, some of patients will succumb to the disease because of development of drug resistance. Still others are primarily refractory to initial therapy. The prog

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!