Dissertations / Theses on the topic 'Azetidinone'
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Gollins, David William. "The use of 2-azetidinone-4-carboxylic acid as a chiral synthon." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386889.
Full textABBIATI, GIORGIO. "Reazioni di cicloaddizione tra 1,3-diazabuta-1,3-dieni e cheteni:sintesi di diidropirimidinoni e 4-immino-azetidinoni." Doctoral thesis, Università degli Studi di Milano, 2000. http://hdl.handle.net/2434/651275.
Full textBurtoloso, Antonio Carlos Bender. "3-azetidinonas e 3-azetidinois : preparação e aplicações na sintese de azetidinas substituidas." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249762.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica
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Doutorado
Quimica Organica
Doutor em Ciências
Murphy, Deirdre M. "STUDIES OF THE METALLO BETA LACTAMASE CCrA FROM BACTERIODES FRAGILIS AND A DANSYLATED MONOCYCLIC BETA LACTAM (1-(5-DIMETHYLAMINO-1-NAPTHALENESULFONYL HYDRAZIDO)-3-ACETAMIDO-4-METHOXY-2-AZETIDINONE." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990561318.
Full textSharma, Madan Kumar. "Approaches to 3,3-disubstituted azetidinones." Thesis, University of Ottawa (Canada), 1990. http://hdl.handle.net/10393/5577.
Full textPearson, Christopher I. "Lithiated azetidine and azetine chemistry." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:cf3c942f-80de-4092-a38d-11006ccbb9ce.
Full textShimamoto, Yasuhiro. "Exploration of New Reactivities of Azetidinols and Alkynylborates." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188616.
Full textLenagh-Snow, Gabriel Matthew Jack. "The synthesis of azetidine and piperidine iminosugars from monosaccharides." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:207235d5-2ea5-4724-92fd-924fa0ccd4ed.
Full textKhan, Rehana Akhter. "Inheritance of azetidine-2-carboxylic acid resistance in Arabidopsis thaliana." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186585.
Full textWebster, P. S. "The ease of carbon-nitrogen bond fission in axetidine derivatives." Thesis, University of Huddersfield, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384650.
Full textADONIAS, MIREILLE. "Synthese de 2-azetidinones trisubstituees inhibiteurs potentiels d'elastases. Nouvelles voie d'acces radicalaire a des cycles carbapenames et carbapenemes." Paris 11, 1993. http://www.theses.fr/1993PA112324.
Full textCararas, Shaine A. "Synthesis and Biological Evaluation of Novel GBR 12909 Tropane and Azetidine Hybrid Analogues." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/565.
Full textO'Gorman, P. A. "Some aspects of the chemistry of small ring organic molecules : 1-azetines, 1-azetidinones, 3-oxo-β-sultams and cyclopropenones." Thesis, University of Huddersfield, 2009. http://eprints.hud.ac.uk/id/eprint/6310/.
Full textSilva, Junior Jose Antunes da. "Estudo da reatividade de 1-azirinas-3-funcionalizadas frente a difenilceteno-sintese de novas 2-pirrolonas e 2-azetidinonas derivadas." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250599.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica
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Doutorado
Kim, Zin Sig [Verfasser], and Dieter [Akademischer Betreuer] Enders. "Asymmetrische Synthese von 1,3-Aminoalkoholen und deren Anwendung zur Synthese von Azetidinen und 1-Azabicyclen / Zin Sig Kim ; Betreuer: Dieter Enders." Aachen : Universitätsbibliothek der RWTH Aachen, 2007. http://d-nb.info/1137488824/34.
Full textNobre, Cintia Maria Rubo de Souza. "Adição de IN3 a derivados de acidos -alquil cinamicos : obtenç2o de 2-alquil-3-fenil-1-azirinas e 3-azido-2-azetidinonas." [s.n.], 1987. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250489.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
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Mestrado
Forsyth, Andrea N. "Synthesis and Biological Evaluation of Rigid Analogues of Methamphetamines." ScholarWorks@UNO, 2012. http://scholarworks.uno.edu/td/1436.
Full textDupas, Alexandre. "Ouverture de composés 1-azabicycliques : synthèse d'azépanes et d'azétidines." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLET026.
Full textNitrogen heterocycles are encountered in numerous natural products and/or bioactive compounds. The development of selective synthetic methods toward nitrogen heterocycles is of prime importance for the discovery of new bioactive compounds in medicinal chemistry of agrochemistry. In this context, our research work has been devoted to the design of regioselective ring-opening reactions of diversely substituted 1-azabicyclic compounds, with the goal of accessing azepanes and azetidines. Several 1-azabicyclo[4.1.0]heptanes were prepared from azirines, through a sequence involving a diastereoslective allylation and a ring-clsoing metathesis reaction to construct the six-membered ring, followed by transformation of the endocyclic olefin using either a hydrogenation, a 1,4-addition or a 1,3-dipolar cycloaddition. Then, different conditions were developed to achieve the ring-opening of the resulting 1 azabicyclo[4.1.0]heptan-2-ones, using carboxylic acids, thiols and thioacids as nucleophiles, which eventually delivered diversely substituted azepanones possessing an ester moiety or a trifluoromethyl group at the alpha position of the nitrogen atom. The diastereoselective cyclopropanation of 2 (trifluoromethyl)azirines was used to elaborate new substituted 1 azabicyclo[1.1.0]butanes, which then underwent regioselective ring-opening with chloroformates and trifluoroacetic anhydride to provide trifluoromethylated 3 chloroazetidines or azetidin-3 ols incorporating two adjacent stereocenters
Mortimer, Claire. "New transformations of azacycles." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:1fe27dc8-6525-4d45-a398-b3e6531e7b99.
Full textCalet, Serge. "Chimie organometallique d'heterocycles a trois chainons (carbonylation, desulfuration, couplage)." Paris 6, 1987. http://www.theses.fr/1987PA066292.
Full textHoncharenko, Dmytro. "Conformationally Constrained Nucleosides, Nucleotides and Oligonucleotides : Design, Synthesis and Properties." Doctoral thesis, Uppsala universitet, Bioorganisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8887.
Full textGlawar, Andreas Felix Gregor. "Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:602edf26-d9ff-4fcf-8dec-c8548f3578da.
Full textVarghese, Oommen P. "Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8266.
Full textPertschi, Romain. "Elaboration d'hétérocycles complexes par ammoniumation catalysée à l'or(I)." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAF036.
Full textNitrogen-containing heterocycles have always retained the attention of chemists considering their potent biological properties as well as their large occurrence in natural product structures. Therefore, the development of new innovative synthetic methods that allow a rapid and efficient access to these heterocycles is highly sought. It is in this philosophy that these PhD works take place, whose aims at the development of new approaches based on gold(I) catalyzed ammoniumation reactions in order to trigger cascade reactions and to reach important nitrogen-containing heterocycles. The N-sulfonyl-2-(1-propargyl) azetidine scaffold allows formation of a large variety of pyrroles and tetrahydroazepines derivatives. The extension of the concept of ammoniumation by using N-(2-alcynylaryl)sulfonyl azetidines allowed the formation of benzosultam derivatives. Another major challenge of modern synthetic chemistry is the formation of enantiopur molecules. To reach this goal, new chiral NHC platinum (II) complexes have been synthesized and evaluated as catalysts for cycloisomerization reactions
Martinand-Lurin, Élodie. "Hétérocycles et réactions pallado-catalysées : développements méthodologiques, études mécanistiques et application en synthèse totale." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112018/document.
Full textThe development of new and more efficient synthetic methodologies, selective and eco-friendly seems to be an ongoing challenge as the interest in the heterocyclic compounds is important. All the studies performed during the last three years are divided in several axes in this field.First, the reactivity of N-(sulfonyl) and N-(sulfamoyl) aziridines as precursors of 1,3-zwitterionic species was explorated in order to obtain various 1-azaspiro[5.n]alkanes. The mechanism of the reaction has been studied by DFT calculations. The initial formation of the zwitterionic 1,3-dipole has been found to be the rate-determining step whereas the five-membered ring closure appeared to be the driving force.We tried to apply our expertise in the field of catalytic nitrene transfers (aziridination and C-H amination) to the total synthesis of pactamycin, highly functionalized aminocyclopentitol compound.Furthermore, the developments of a Passerini-Smiles/reduction/cyclization cascade and of a one-pot Passerini-Double-Smiles/SNAr sequence provide straightforward and efficient accesses to 1,4-benzoxazin-3-ones. These paths are complementary as they lead to regioisomers.Meanwhile, a new methodology based on Pd-catalyzed thiocyclopropanes ring opening gave thiochromenes. Due to their high synthetic potential, these compounds appear to be very promising scaffolds in heterocyclic chemistry.Finally, electrochemical and NMR studies coupled with DFT calculations have been done in order to elucidate the mechanism involved in the Pd-catalyzed couplings between an aryl halide, an isocyanide and a nucleophile
"3-azetidinonas e 3-azetidinois : preparação e aplicações na sintese de azetidinas substituidas." Tese, Biblioteca Digital da Unicamp, 2006. http://libdigi.unicamp.br/document/?code=vtls000377636.
Full textSajjadi, Hashemi Zohreh. "Substituted azetidine-2 carboxylic acid synthesis." Thèse, 2006. http://hdl.handle.net/1866/16791.
Full textWang, Shih-Chieh, and 王世杰. "The Azetidine Chemistry for Aqueous-based Polyurethane and Other Applications." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/22425065775437069592.
Full text淡江大學
化學學系博士班
95
In this research, the modification of aqueous-based polyurethane (PU) dispersion is the main target. Because the traditional aqueous-based PU resin is linear polymer and because it has low average molecular weight which causes the traditional aqueous-based PU exhibits poor organic solvent resistant and low mechanical performance. In this research, a series of azetidinyl-containing curing agent, triaziridinyl-containing curing agent, mono-aziridinyl and mono-isocyanate containing curing agent and tri-oxirane-containing curing agent are synthesized and introduced into aqueous-based PU dispersion to act as the latent curing agent at ambient temperature. The chemical structures of these synthesized curing agents are identified by FT-IR and FT-NMR. The curing reaction between curing agent and PU is explained by the modeling reaction. The physical properties (such as gel content, water-uptake, degree of alcohol swollen, contact angle, hardness etc.), the tensile strength, the thermal properties of these cured PU resins are evaluated in this research.
LEE, KANG MAN. "BIOSYNTHESIS OF L-AZETIDINE-2-CARBOXYLIC ACID IN ACTINOPLANES FERRUGINEUS." 1985. http://catalog.hathitrust.org/api/volumes/oclc/68296740.html.
Full textYEUNG, KING-FAI. "DEGRADATION OF L-AZETIDINE-2-CARBOXYLIC ACID BY ENTEROBACTER AGGLOMERANS AND E. AMNIGENUS." 1987. http://books.google.com/books?id=8URtAAAAMAAJ.
Full textHsin-Yi, Wei, and 魏欣怡. "Study on Nylon 6 Synthesis via Anionic Polymerization Using Azetidine-2,4-diones as the Activators." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/77557112602501694593.
Full text國立中興大學
化學工程學系
93
This research focused on the study of anionic ring-opening polymerization of caprolactum to synthesize Nylon 6 using structurally varied azetidine-2, 4-diones as the activators. The polymerizations were carried out by a one-step melt-process to find out the effects of activator’s concentration, types (aromatic or aliphatic), functionalities ( n=1 and 2), substituents (on azetidine-2,4-dione ring) as well as those of reaction temperature on polymerization rates. The aim is to find the best activator and optimal condition for possible application in reaction injection polymerization of Nylon 6 (Nylon RIM). In the aromatic series, different aliphatic substituent groups at 3,3’-prosition of azetidine-2,4-dione rings showed great effects on conversion rate and time of Nylon 6’s crystallization. It was found that aromatic bisazetidine-2,4-diones based on MDI with 3,3’-diethyl- or 3-ethyl-3’-butyl-groups exhibited the best overall performances which were twice as fast than that of N,N’-isophthaloyl-bis-caprolactam in getting high molecular weight Nylon 6 (molecular wt. of ~70,000) in about 70 seconds at 140℃. Unexpectedly, substitution of less-hindered di-methyl groups at 3, 3’-positions of the ring resulted in a slower polymerization and crystallization of Nylon 6. Complications of cross-linking and branching in the polymerization seemed responsible for this abnormality. Further study on Nylon-6 polymerizations were also conducted with bis-azetidine-2, 4-diones possessing long-chained polyether groups derived from Jeffamine D4000 Polymerization of Nylon-6 on the azetidine-2,4-dione prepolymers resulted in the formation of triblock-type systems. As might be expected in these cases, the polymerization rate of caprolactum was inversely proportional to the content of polyether groups in the prepolyemrs due to dilution. The triblock polymer prepared exhibited a well-organized phase-segregation in its morphology.
Gries, Jörg [Verfasser]. "1,3-Aminoalkohole als Bausteine in der asymmetrischen Synthese von Azetidinen, Azetidincarbonsäuren und Piperidin-3-olen / vorgelegt von Jörg Gries." 2005. http://d-nb.info/977243362/34.
Full textCheng, Hsin-Yu, and 張新佑. "Rapid Melt Synthesis of Elastomers from Bis-azetidine-2,4-dione Intermediates and Study of their Structure and Morphology Relationships." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/12161778229001993677.
Full text國立中興大學
化學工程學系所
94
Two methods of synthesizing bis-azetidiene-2, 4-dione intermediates have been accomplished in our lab for preparation of three bis-azetidine-2, 4-dione, PBAZ, MBAZ, and LBAZ for our study. Using a thermal process, diethylketene cyclo-adds to aromatic diisocyanates to form aromatic bis-azetidine-2, 4-diones. The yields of bis-aztidine-2, 4-diones from p-phenylene diisocyanate(PPDI) and 4, 4’-dipehnylene diisocyanate (4, 4’-MDI) were found to be 74% (for PBAZ) and 82% (MBAZ) respectively. Whereas, N, N’-hexamethylene bis-azetidine-2, 4-dione(LBAZ) an aliphatic counterpart, was prepared differently by photolysis of hexamethylene-bis-N-formyl-N-methacrylamides in 71%. Melt-polymerization of bis-azetidine-2, 4-diones with hexamethylene diamine yielded polymalonamides. Similar melt-polymerization has also been extended to synthesize polymolonamide elastomers using Jeffamine® D2000 as the soft-segment component and hexamethylene diamine as the extender with each of the prepared bis-azetidine-2, 4-diones. Elastomers of 35%, 45% and 55% hard-segment contents in each series were prepared. All syntheses were carried out by a two-step process by formation of pre-polymers between individual azetidine-2, 4-diones with Jeffamine* in the first step. The second step to the final product was done with hexamethylene diamine as the extender. Very rapid conversions to the final products were observed universally in less than 150 sec. The polymalonamide elastomers prepared were analyzed by TGA, DSC, DMA, AFM and FE-SEM to characterize morphology of the products. All elastomers prepared from PBAZ and LBAZ are semi-crystalline in nature. Especially, three PBAZ derived elastomers crystallize readily to form distinctive oval island-shape domains as observed by AFM, and are characterized by their sharp Tg,s and Tg,h in DSC and DMA. The domain sizes are uniformly distributed between 200nm to 300nm with increasing larger sizes for higher hard-segment contents. Although semi-crystalline LBAZ-derived elastomers also showed similar phase-segregation in AFM, but their patterns were different and could be influenced greatly by processing techniques. Under high spinning rates of greater than 4000 rpm in spin-coating process, the morphology of LBAZ-elastomers turned into fibrous pattern. Our study indicated that only MBAZ-elastomers are amorphous and showed well mixing between hard and soft segments as indicated by the appearances of Tg,s and new Tg,m at -10~18℃ for the mixed phases in DSC. The physical properties of elastomers have been found to be greatly influenced by morphology and by the hard-segment contents but appeared to be in lesser degrees for the latters.
Hsu, Chih-Hsiung, and 許智雄. "Determination of critical micelle concentration of dendritic surfactant synthesized via a selective ring-opening addition reaction of azetidine-2,4-dione." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/48291832529694579404.
Full text中興大學
化學工程學系所
99
In this study, a series of dendrons with four carbons were synthesized and extended to obtain a dendritic surfactant. An azetidine-2,4-dione has been applied to synthesize dendrons on account of the characteristic of ring-opening reactions. The characteristics of [G-1]-C4 dendron were examined by fourier transform infrared (FT-IR), 1H nuclear magnetic resonance (1H NMR), elemental analyzsis (EA) and fast atom bombardment mass spectrometry (FAB MS) analyses. The dendritic surfactant was obtained from [G-1]-C4 dendron and dissolved in 2 wt % dimethyl sulfoxide (DMSO) water-DMSO solution to observe the critical micelle concentration (CMC). This dendritic surfactant was ionic with hydrophilic and hydrophobic groups. The CMC was determined by electrical conductivity and fluorescence measurements. From this result, the CMC was very close within measurements. Moreover, transmission electron microscopy (TEM) could confirm the formation and shape of micelle. Zeta potential measurement also provided an evidence of forming micelles. To extend the application, it adsorbed anion dyes successfully by its cation head group.
Lee, Jiyeon. "Analysis of the enzymological properties of prolyl-tRNA synthetases in plants focusing on the misactivation of the proline analog azetidine-2-carboxylic acid." 2009. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052259.
Full textSung, Wei-Wen, and 宋維文. "Part I : Immunolocalization of Oryza sativa ClassⅠLow Molecular Mass Heat Shock Protein Expressed in E. coli in Relation to Thermotolerance Part II : Immunolocalization of Azetidine Induced Class I Low-Molecular- Mass Heat Shock Proteins in Soybean." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/77152902829913943363.
Full text國立臺灣大學
植物學研究所
89
Escherichia coli cells were transformed with pUC8 (pUC8 vector only), pUC-FL (rice class I low molecular mass heat shock protein Oshsp16.9 cDNA ORF inserted into pUC8), and pUC-C108 plasmids (DNA fragment containing C-terminal 108 amino acids of Oshsp16.9 cDNA ORF inserted into pUC8) previously in our laboratory and the recombinant proteins were expressed. In the present study, the ultrastructural changes of the transformed E. coli cells affected by heat shock were studied with electron microscopy. Meanwhile, immunolocalization and the movement of Oshsp16.9 or its fragment in E. coli cells affected by heat shock were also reported. Escherichia coli grown under normal environment, cells was enclosed by cell wall with dense ectoplasm and more or less light endoplasm, in which nucleoid region located. With IPTG induction or heat treatment, some dark regions were found in ectoplasm. Having been transferred back to 37℃ after heat shock, about 27% of pUC-FL cells pretreated with IPTG induction recovered to normal. Cells without IPTG pretreatment, only had 0~8% of recovery. These results are in agreement with the thermoprotection of Oshsp16.9. Immunolocalization of Oshsp16.9 expressed in E. coli after IPTG induction were found both in pUC-FL and pUC-C108 transformed clones. Quantitative comparison of immuno-gold particles in cells under different treatments showed results as follows: there was a distinct difference in Oshsp16.9 expression of cells with and without IPTG induction; there was no conspicuous movement of Oshsp16.9 in normal or high temperature environment; and the density of gold particles in dark regions was higher than that in other regions. In the second part of this thesis, class I low molecular mass heat shock protein induced by azetidine were precipitated with mitochondria by subcellular fraction were investigated. In this issue, immunolocalization of soybean class I low molecular mass heat shock protein induced by azetidine were performed. Most of the class I low molecular mass heat shock protein accumulated in the cytoplasm and the less around mitochondria of soybean seedlings pretreated by azetidine. When seedlings pretreated with azetidine were transferred back to normal condition and their heat shock proteins would move to cytosol. When soybean seedlings pretreated with azetidine were shifted to heat shock of 40℃, the class I heat shock proteins were observed more abundant in cytosol.