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Mori, Graziela Garrido, Ivaldo Gomes de Moraes, Daniele Clapes Nunes, Lithiene Ribeiro Castilho, and Wilson Roberto Poi. "Biocompatibility of acetazolamide pastes in the subcutaneous tissue of rats." Brazilian Dental Journal 20, no. 1 (2009): 17–21. http://dx.doi.org/10.1590/s0103-64402009000100002.
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This aim of this study was to investigate the biocompatibility of two experimental acetazolamide (AZ)-based pastes in the subcutaneous tissue of rats. Both pastes contained AZ as the main component in similar concentration. The vehicle in experimental paste 1 was saline, while experimental paste 2 was prepared with propylene glycol. Sixty polyethylene tubes were sealed at one end with gutta-percha (GP), which served as a control. Half of the tubes were filled with paste 1 and half with paste 2. The tubes were implanted in the subcutaneous tissue of 15 rats, being 4 tubes for each animal. The animals were killed 7, 15 and 45 days after surgery and the specimens were processed in laboratory. The histological sections were stained with hematoxylin and eosin and were analyzed by light microscopy. Scores were assigned to level of inflammatory process: 1- none; 2- mild; 3- moderate; 4- severe. The data were analyzed statistically by the Kruskal-Wallis test (p≤0.05). Paste 1 produced an inflammatory process at 7 days. However, the intensity of this inflammation decreased with time and was nearly absent at 45 days. No statistically significant difference (p>0.05) was observed between the control (GP) and paste 1. However, paste 2 produced inflammatory response at all study periods and differed significantly (p<0.05) from the control. In conclusion, in the present study, the experimental AZ-based paste 1 was considered as biocompatible as the control matrial (GP), while experimental paste 2 was irritating to rat subcutaneous tissue.
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Patel, Raina A., Imran Ahmad, Christine E. Sheehan, Jeffrey S. Ross, George D. Wilner, Alida Hayner-Buchan, and Tipu Nazeer. "Expression of Phosphorylated mTOR (p-mTOR) Correlates with Advanced Stage in Diffuse Large B-Cell Lymphomas." Blood 110, no. 11 (November 16, 2007): 1573. http://dx.doi.org/10.1182/blood.v110.11.1573.1573.
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Abstract Background: The mammalian target of rapamycin (mTOR), plays a major role in regulating cell growth. The activated form of mTOR (phosphorylated mTOR) mediates its effects through mitogen and nutrient dependant signal transduction that regulates mRNA translation. Levels of phosphorylated mTOR (p-mTOR) have been shown to correlate with cell proliferation and inhibition of the mTOR pathway has shown therapeutic promise in some tumors. Information on the role of p-mTOR in hematopoietic malignancies is limited. The aim of the current study is to evaluate the expression of p-mTOR in diffuse large B-cell lymphomas. Design: Formalin-fixed paraffin-embedded tissue sections from 45 DLBCLs were immunostained by an automated method (Ventana Medical Systems, Inc., Tucson, AZ) using p-mTOR rabbit monoclonal antibody (IHC specific Ser2448/49F9; Cell Signaling Technology, Inc., Danvers, MA). Immunoreactivity (cytoplasmic with membranous accentuation) was semiquantitatively assessed based on p-mTOR stain intensity (none, weak, moderate, intense) and distribution (none, focal<10%, regional 11–50%, diffuse>50%). Staining was correlated with histologic and prognostic factors. Results: Membranous/cytoplasmic p-mTOR immunoreactivity was present in 88% of DLBCLs and correlated with advanced tumor stage, with 100% advanced stage versus 73% low stage tumors expressing membranous/cytoplasmic p-mTOR protein (p=0.002). One hundred percent of cases with complete absence of p-mTOR immunoreactivity were low stage DLBCLs. Conclusion: Membranous/cytoplasmic protein expression of p-mTOR correlates with advanced stage in DLBCL. Activated mTOR may play an important role in disease progression and provide a target for therapy in DLBCL. Further studies of the m-TOR pathway in hematopoietic malignancies appear warranted.
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Ateyah, Nasrien Z., and Ahmed A. Elhejazi. "Shear Bond Strengths and Microleakage of Four Types of Dentin Adhesive Materials." Journal of Contemporary Dental Practice 5, no. 1 (2004): 63–73. http://dx.doi.org/10.5005/jcdp-5-1-63.
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Abstract The aim of this investigation was to compare the microleakage of composite resin (Z-100) and shear bond strength to bovine dentin using different types of adhesive systems (Scotch Bond Multi-Purpose, All-Bond 2, One-Step, and Perma Quick) to compare and correlate microleakage to shear bond strength. For the microleakage aspect of the study, 20 class V were prepared (bovine incisors) with 90-degree cavosurface margins and were located at the cemento-enamel junction using a template. Each dentin bonding system was applied to five cavities following the manufacturer's instructions and restored with Z-100 composite resin. After 24 hours of storage in distilled water at 37°C, the teeth were immersed in 2% basic fuchsin dye. All teeth were sectioned in a mesiodistal direction using a diamond saw, and each section was then inspected under a stereomacroscope. For the shear bond strength aspect of the study, 20 bovine incisors were centrally horizontally mounted in Teflon mold with cold cure acrylic resin. Flat labial dentin surfaces were prepared using different grit silicon carbide abrasive wheels. Five specimens were used for each of the bonding agent systems. Each specimen was bonded with restorative composite resin (Z-100) and applied to the treated dentinal surface through a split Teflon mold. All specimens were stored in distilled water at 37°C for 24 hours. The bonds were stressed using shear forces at a crosshead speed of 0.5mm/min using an Instron Universal testing machine. Findings indicate none of the systems tested in this study were free from microleakage. Scotch bond multipurpose achieved the best seal, with One-Step being second best, while All-Bond 2 and Perma Quick had the poorest seal. However, there were significant differences among the shear bond strengths of the four bonding systems tested. Scotch Bond Multi-Purpose has a higher bond strength to composite resin when compared to the other dentin adhesives. The study also concluded there is no association between microleakage and shear bond strength. Citation Ateyah AZ, Elhejazi AA. Shear Bond Strengths and Microleakage of Four Types of Dentin Adhesive Materials. J Contemp Dent Pract 2004 February;(5)1:063-073.
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Marcath, Lauren A., Taylor D. Coe, Bruce G. Redman, and Daniel Louis Hertz. "Development of a drug-drug interaction screening tool for oncology clinical trial enrollment." Journal of Clinical Oncology 36, no. 30_suppl (October 20, 2018): 315. http://dx.doi.org/10.1200/jco.2018.36.30_suppl.315.
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315 Background: Screening drug-drug interactions (DDI) for subjects enrolling in oncology clinical trials is critical to ensuring patient safety and the validity of clinical trial data. We previously reported that DDI screening is not uniformly conducted when screening patients for enrollment into SWOG clinical trials and found that at the University of Michigan Rogel Cancer Center up to 24.2% of subjects enrolled in National Clinical Trial Network (NCTN) trials had a DDI. Screening tools aid in DDI reduction in clinical practice, but none have been created for clinical trial enrollment. Our objective was to develop a clinical trial specific DDI screening tool based on features requested by the end-users of the tool at U-M. Methods: Semi-structured and informal interviews were conducted with all data managers who enroll patients into NCTN clinical trials at the U-M cancer center. Data managers were asked about their current workflow and desired features of a DDI screening tool. Responses were combined and reviewed for feasibility. Desired features were conveyed to PEPID, LLC (Phoenix, AZ) for tool development. Results: Four data managers were interviewed. Protocol-guided screening was a key workflow feature, which was completed by gathering DDI information primarily from the exclusion criteria and drug information sections of each respective protocol, Google, CredibleMeds, and the Indiana University P450 Drug Interaction Table. Consequently, a critical feature was the display of drug characteristics with wording that aligned with that in the protocol including transporter and CYP450 substrates, inhibitors, or inducers and QT prolongation potential. Additional desirable features included separate entry of study and concomitant drugs, filtering to display only DDI with study drugs, and PDF export of results. PEPID developed a prototype tool including these desired attributes for a prospective implementation pilot study. Conclusions: A first generation clinical trial specific DDI screening tool was developed based on end-user feedback. We are designing a prospective study to determine whether implementation of this tool can reduce DDI, enhance patient safety, and ensure validity of clinical trial data.
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Papp, Zoltán, István Petri, Erzsébet Villányi, László Tiszlavicz, and Gyula Ugocsai. "Deciduosis causing perforating appendicitis in the early postpartum period following caesarean section." Orvosi Hetilap 149, no. 7 (February 1, 2008): 329–31. http://dx.doi.org/10.1556/oh.2008.28227.
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A szerzők közleményükben egy 29 éves, először terhes, először szülő asszony kórtörténetét ismertetik, akinél a terhesség 39. hetében akut intrauterin magzati distress (köldökzsinór-szövődmény) miatt császármetszés, majd az 5. posztoperatív napon gangraneas, perforált appendix eltávolítása történt. A féregnyúlvány hisztológiai vizsgálata a bélfalat teljes vastagságában érintő „agresszív” deciduosist írt le. Közleményükben kitérnek a ritka kórkép tanulságaira. Az esetismertetés az első olyan magyar nyelvű közlemény, amelyben az appendixre lokalizálódó deciduosisról számolnak be, és egyben az első nemzetközi publikáció is, melyben császármetszést követően kialakult deciduosis okozta appendicitis miatt appendectomiára került sor.
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Fischer, Tamás. "Vascular endothelial dysfunction, oxidative stress – a new topic within the referal section of Orvosi Hetilap." Orvosi Hetilap 149, no. 28 (July 1, 2008): 1323–27. http://dx.doi.org/10.1556/oh.2008.28402.
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A szerző a folyóirat-referáló rovat „Érendothel-funkciózavar, oxidatív stressz” tárgykörrel való bővítésének fontosságát szakmailag – a téma nagyságára való tekintettel – néhány önkényesen kiemelt kérdéskör kibontásával támasztja alá: Az endothelium a belső környezet állandóságát, integritását vigyázza, azt különböző anyagok termelésével-elválasztásával, azoknak egyensúlyban tartásával biztosítja. Ha az erek belfelületét, intimáját érő mechanikai, fizikai, kémiai, mikrobiológiai, immunológiai, genetikai károsító téyezők – vagy azok valamelyikének kombinációja – ellen foganatosított válaszreakció folyamán megbomlik az egyensúly az endothelium termelte vasoconstrictorok és vasodilatatorok, a növekedési faktorok és azok gátlói, a proinflammátorok és antiinflammátorok, a protrombotikus és fibrinolitikus tényezők között, endothel-működészavarról beszélünk. Az idült érbetegség, az atherosclerosis indító eseménye az erek hatalmas belfelületén, az endothelsejtekben megy végbe, ezt nevezzük endotheldiszfunkciónak . Az érpatogén tényezők, a rizikófaktorok mindegyike endothel-működészavar , endotheldiszfunkció indukálásával vezet idült (cardio)vascularis megbetegedéshez. Az élettani oxidatív metabolizmus során végbemenő fiziológiás szabad gyökös folyamatok – a védekező-kompenzáló endogén antioxidatív faktorok kimerülésekor – oxidatív stresszt , a veszélyeztető tényezők okozta endothel-működészavart okoznak. Nyomatékosan kiemelendő a „kauzális”, intracellulárisan, mitokondriálisan ható antioxidánsok (sztatinok, angiotenzinkonvertálóenzim-gátlók, angiotenzinreceptor-blokkolók, acetilszalicilsav, a harmadik generációs béta-blokkolók) terápiás, preventív terápiás fontossága, a humán érrendszer élettani, kórélettani, terápiás konszubsztancialitásának, egylényegűségének és az endotheldiszfunkció szisztémás jellegének, az érrendszeri eseményláncolat preventív terápiás jelentőségének kulcsfontossága. Az oxidatív stressz, a konszekutív endotheldiszfunkció területén végbement hatalmas fejlődés a klinikai látásmódot alapjaiban átalakító momentum.
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Judit, Szigeti, Csányi Viktor, and Rózsa Zoltán. "Régészeti Adatok Az Árpád-Kor Kerámiaművességéhez: Székkutas, Sós-Halmi-Dűlő." Archaeologiai Értesítő 145, no. 1 (December 22, 2020): 157–87. http://dx.doi.org/10.1556/0208.2020.00007.
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Tanulmányunkban egy 2014–15 folyamán, Székkutason (Csongrád megye) feltárt Árpád-kori településrészlet házaiból előkerült kerámiaanyag feldolgozásának eredményeit mutatjuk be, adalékkal szolgálva a 12. századi kerámiakutatás adataihoz.Presented here are the results of the assessment of the pottery finds from the houses of an Árpádian Age settlement, a section of which was uncovered at Székkutas (County Csongrád) in 2014–2015, which can contribute to studies on 12th-century pottery.
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Jung, Young-Dae, and Soo-Yong Rhee. "Photorecombination of Electrons in Dense Plasmas." Zeitschrift für Naturforschung A 55, no. 3-4 (April 1, 2000): 457–59. http://dx.doi.org/10.1515/zna-2000-3-413.
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Abstract The plasma screening effect on the photorecombination of free electrons, with ions in a weakly plas-ma is investigated. The recombination cross section is obtained by the principle of detailed balance with the photoionization cross section of the hydrogenic ion including the plasma screening effects on the bound and continuum states of the electron. It is found that the plasma screening effects on the recom-bination cross section are less than 11% when the Debye length (Λ) is greater than ten times of the Bohr radius (az) of the hydrogenic ion with nuclear charge Z
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Varga, József, Gyöngyi Bánkuti, Ádám Csuvár, and Tekla Sebestyénné Szép. "MEW és az ISEW alternatív gazdasági mutatók elméleti áttekintése." Acta Scientiarum Socialium, no. 49 (November 28, 2019): 9–16. http://dx.doi.org/10.33566/asc.2527.
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In our publication we focus on the economic well-being indicators that can be good substitutes or alternatives of the gross domestic product. After the brief overview of the often mentioned weaknesses and mistakes of GDP, we present the Measure of Economic Welfare (MEW) and the Index of Sustainable Economic Welfare (ISEW). We summarize that albeit there are more than enough indicators, none of them is so widely accepted as GDP. It is not clear yet which one(s) will replace it in its role. The study was created for the Economics Seminar of Kaposvár (KAKTUSZ) which is organized annually by the Kaposvár University. Another research team of the environmental economics session of KAKTUSZ 2016 undertakes to demonstrate other alternative economic indicators in the article titled "Theoretical overview of the GPI, the SNBI and the HDI alternative economic indicators" by Csuvár et al. (2018).
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Buglio, Daniela, Sangeetha Palakurti, Francisco Vega, Sattva S. Neelapu, Donald Berry, Yuan Ji, Kate Byth, and Anas Younes. "Inhibition of Tak-1 by AZ-Tak1 Impairs NF-κB Activation, Downregulates XIAP and Activates Caspase-9 Inducing Apoptosis In Mantle Cell lymphoma." Blood 116, no. 21 (November 19, 2010): 2852. http://dx.doi.org/10.1182/blood.v116.21.2852.2852.
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Abstract Abstract 2852 TGF-b-activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, plays a key role in regulating inflammation, immunity, metabolism, and cell death in a variety of cell types. It is activated in response to a variety of cytokines, including tumor necrosis factor (TNF), TGF-b, and interleukin 1 (IL-1). Upon receptor binding, TAK1 binds to adaptor proteins, and subsequently phosphorylate downstream molecules leading to activation of p38MAPK, JNK, and NF-kB. In this study, we examined the expression pattern of TAK1 and its potential therapeutic role as a target for lymphoma. First, we examined TAK1 expression in a panel of lymphoid cell lines by western blot, and found it to be highly expressed in mantle cell lymphoma cell lines (Mino, SP53, and Jeko-1). In contrast, PBL from healthy donors had no expression of TAK1 protein. TAK1 was also highly expressed in primary lymph node sections of MCL compared with benign reactive lymph nodes. Subsequently, we investigated the in vitro activity of the novel TAK1 small molecule inhibitor AZ-Tak1 in these cell lines. AZ-Tak1 is a potent and a relatively selective inhibitor of TAK1 kinase activity, with an IC50 of 0.009 mM. AZ-Tak1 treatment decreased the level of p38 and ERK in mantle cell lymphoma cells, and induced apoptosis in a dose and time dependent manner, with an IC50 of 0.1–0.5 mM. Using the annexin-V and PI staining and FACS analysis, After 48 hours of incubation, AZ-Tak1 (0.1 mM) induced apoptosis in 28%, 34% and 86% of Mino, SP53, and Jeko cells, respectively, which was increased to 32%, 42%, and 86% when 0.5 mM concentration was used. Similar activity was also observed when TAK1 expression in MCL cells was downregulated by TAK1- specific SiRNA and when primary mantle cell lymphoma specimens were examined after treatment with AZ-Tak1 for 24h (300nM). Using pathway-specific protein arrays focusing on apoptosis, kinases, and transcription factors, AZ-Tak1 (0.5 mM) altered the level of several proteins that regulate cell growth and survival, especially members of the inhibitors of apoptosis (IAP) family. Specifically, nuclear NF-κB p65 levels were decreased, cytosolic levels of SMAC/DIABLO and cytochrome-C were increased in AZ-Tak1 treated cells, which were associated with a decrease in the level of the anti-apoptotic protein X-linked IAP (XIAP) and activation of the intrinsic apoptotic pathway as evident by activation of caspase 9, cleavage of caspase 3, and consequent cells apoptosis. Collectively, our data demonstrate that TAK1 is essential for MAPK and NF-κB activation. Inhibition of TAK1 by the small molecule inhibitor AZ-Tak1 or TAK1-SiRNA induces cell death in mantle cell lymphoma by activating the intrinsic apoptosis pathway, suggesting that targeting TAK1 may have a therapeutic value for the treatment of mantle cell lymphoma. Disclosures: No relevant conflicts of interest to declare.
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Vigh, László Gergely, Dániel Honfi, László Dunai, Ádám Zsarnóczay, József Simon, Máté Dohány, and Zsolt Berki. "Seismic resilience assessment of critical infrastructures – Case study of M1 highway bridges." Scientia et Securitas 2, no. 4 (March 26, 2022): 440–51. http://dx.doi.org/10.1556/112.2021.00073.
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Summary. Safety and security of critical infrastructure networks is one of today’s top priorities, as they are getting increasingly complex and interdependent. Thus, their potential failure due to unforeseen and extreme events may result in excessive direct and indirect losses. Recently, focus has shifted from protection to resilience, i.e. the ability of a system exposed to a hazard not only to resist, but accommodate to and recover from the hazard effects. This paper – by the implementation of the IMPROVER technological resilience analysis – demonstrates the seismic technological resilience assessment of a section of M1 Highway in Hungary. Resilience against the community’s tolerances as well as risk-based resilience indicators are evaluated. The results suggest that technological resilience could be improved, thus certain resilience treatment options are highlighted. Összefoglalás. A kritikus infrastruktúra-hálózatok biztonsága napjaink egyik legfontosabb prioritása, mivel ezek egyre összetettebbek és kölcsönösen függnek egymástól. Így az előre nem látható és szélsőséges események miatti esetleges meghibásodásuk túlzott mértékű közvetlen és közvetett veszteséget eredményezhet. A közelmúltban a hangsúly a védelemről a rezilienciára, rugalmasságra helyeződött át, vagyis a veszélynek kitett rendszer azon képességére, hogy nemcsak ellenálljon, hanem alkalmazkodjon is a veszélyhatásokhoz, és helyreálljon azokból. Jelen cikk – az IMPROVER technológiai ellenállóképesség-elemzés felhasználásával – az M1-es autópálya egy szakaszának szeizmikus technológiai ellenálló képességének vizsgálatát mutatja be. Az értékelés az IMPROVER keretein belül kifejlesztett, az ISO 31000 kockázatkezelési folyamatába integrálódó ICI-REF keretrendszert (IMPROVER Critical Infrastructure Framework) követi. A keretrendszer különféle módszereket ajánl a kritikus infrastruktúra ellenálló képességének felmérésére. Elsőként meghatározzuk és számszerűsítjük a vizsgált szakasz szeizmikus veszélyeztetettségét a valószínűségi szeizmikus veszélyeztetettségi analízis segítségével, melynek eredményeképpen a helyszíneknek a spektrális gyorsulás – túllépési valószínűség kapcsolatát mutató veszélyeztetettségi görbéit kapjuk meg. Ezt követően különböző károsodási szintekhez meghatározzuk az érintett hídszerkezetek sérülékenységi görbéit, mely a spektrális gyorsuláshoz tartozó tönkremeneteli valószínűséget mutatja. Az esemény és a károsodás bekövetkezte esetén megváltozó útpálya kapacitás és forgalmi helyzet alapján az áteresztő képesség csökkenése mellett a menetidőtöbblet is számítható, így a közvetlen károk költségei mellett az indirekt költségek is számszerűsíthetőek, és így a bekövetkezési valószínűségekből és a költségekből a kockázatot számítjuk. Értékeljük a közösség toleranciáival szembeni rezilienciát, valamint a kockázatalapú reziliencia mutatókat. Részletes leírást adunk a forgalomszimulációkat is magában foglaló katasztrófaelhárítási és helyreállítási modellek alkalmazásáról. A cél az, hogy kiszámítsuk a várható felhasználói késések időbeli alakulását a különböző elemzett forgatókönyveknél, és összegezzük az ebből eredő várható költségeket a végső helyreállításig. A reziliencia értékelése két megközelítésen alapul: 1) összehasonlítás a felhasználói toleranciával, és 2) a reziliensség kockázatalapú értékelése. Az eredmények alapján a technológiai reziliensség javítható, melyre több kezelési lehetőséget is felvázolunk. Az autópálya komplex reziliencia-kezelési stratégiáinak kidolgozásakor azonban az IMPROVER-en belül kifejlesztett egyéb módszerek, például a szervezetelemzés (IORA) és a holisztikus önértékelési (CIRI) eszközök eredményeire is támaszkodni szükséges.
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Wiley, M. M., B. Khatri, K. L. Tessneer, M. L. Joachims, A. M. Stolarczyk, A. Rasmussen, S. J. Bowman, et al. "OP0139 FUNCTIONAL EVALUATION OF THE SJÖGREN’S SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVAL." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 89.1–90. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3935.
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Background:Sjögren’s Syndrome (SS) and Systemic Lupus Erythematosus (SLE) are distinct chronic, complex autoimmune diseases with shared characteristics such as autoantibodies, heightened interferons, and polyarthritis. SS and SLE genome-wide association studies (GWAS) report strong associations with theDDX6-CXCR5risk interval. DDX6 suppresses interferon stimulated gene expression and CXCR5 regulates T cell functions implicated in autoimmunity.Objectives:To identify functional variants that impact regulation in theDDX6-CXCR5interval.Methods:Fine-mapping was done using ImmunoChip data from 3785 SLE, 1916 SS cases and 6893 population controls of European ancestry that were imputed and tested for SNP-trait association. Bayesian statistics assigned posterior probabilities to SNPs and defined a credible set of risk variants. Bioinformatic analyses further prioritized variants with predicted functionality. Electrophoretic mobility shift assays (EMSAs) and luciferase expression were used to validate predicted SNPs in EBV transformed B (EBV B) cells.Results:While some differences were observed, the overall SS and SLE association signals were similar. SNP-SS rs9736016 nearCXCR5and SNP-SLE rs76409436 nearDDX6were the most significant but did not show evidence of functionality. Bayesian statistics defined credible sets of variants in strong D’ in common between both SS and SLE. Bioinformatics analyses (Haploreg, RegulomeDB, ENCODE data, etc) further refined the credible set and identified 5 common SNPs with strong evidence of functionality in immune cell types: rs4938572, rs4936443, rs57494551, rs7117261 and rs4938573. EMSAs showed a significant increase in protein binding to the risk allele of rs57494551 (p=0.0001), rs7117261 (p=0.0001) and rs4938573 (p=0.0003), but not the others, using nuclear lysates from EBV B cells. Luciferase vectors with a minimal promoter or no promoter were used to test for enhancer or promoter activity, respectively. To this end, the rs57494551 risk allele exhibited a significant increase in enhancer activity (p=0.0001). In contrast, the rs7117261 risk allele decreased enhancer activity (p=0.018). The rs4938573 risk allele decreased enhancer (p=0.043) and promoter (p=0.024) activity. While rs7117261 or rs4938573 were not reported in eQTL databases, GTex data reported rs57494551 as an eQTL that altersDDX6expression in whole blood (p=1.8E-7). Additionally, these functional SNPs have been associated with looping events to several proximal promoters in nearby genes in immune cells.Conclusion:SS and SLE have similar genomic architecture across theDDX6-CXCR5risk interval. Multiple variants in the credible set exhibited allele specific changes in protein binding, as well as modified enhancer activity, promoter activity or both. Ongoing studies will use Cas9 in EBV B cells to determine which other loci are within the local regulatory network.Disclosure of Interests:Mandi M Wiley: None declared, Bhuwan Khatri: None declared, Kandice L Tessneer: None declared, Michelle L Joachims: None declared, Anna M Stolarczyk: None declared, Astrid Rasmussen Speakers bureau: Novartis, ThermoFischer, Simon J. Bowman Consultant of: Astrazeneca, Biogen, BMS, Celgene, Medimmune, MTPharma, Novartis, Ono, UCB, xtlbio, Glapagos, Speakers bureau: Novartis, Lida Radfar: None declared, Roald Omdal: None declared, Marie Wahren-Herlenius: None declared, Blake M Warner: None declared, Torsten Witte: None declared, Roland Jonsson: None declared, Maureen Rischmueller: None declared, Patrick M Gaffney: None declared, Judith A. James Grant/research support from: Progentec Diagnostics, Inc, Consultant of: Abbvie, Novartis, Jannsen, Lars Ronnblom Grant/research support from: AZ, Speakers bureau: AZ, R Hal Scofield Grant/research support from: Pfizer, Xavier Mariette: None declared, Wan-fai Ng: None declared, Kathy L Sivils: None declared, Gunnel Nordmark: None declared, Betty Tsao: None declared, Christopher Lessard: None declared
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Bujtor, László, Hans-Jürgen Gawlick, Ákos Miklósy, Richárd Albrecht, Alex Kovács, Bertalan Makó, Dávid Maróti, and Sigrid Missioni. "Az első kréta időszaki nautilida-előfordulás (Eutrephoceras ex gr. boissieri) a Mecsekből." Földtani Közlöny 149, no. 1 (April 14, 2019): 19–24. http://dx.doi.org/10.23928/foldt.kozl.2019.149.1.19.
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Fieldwork around the lime-kilns at Zengővárkony (southern Hungary, eastern Mecsek Mts.) has led to the discovery of previously unknown beds of the Hidasivölgy Marl Formation. Based on bio- and lithostratigraphic considerations, here a Valanginian (Hauterivian?) age is assumed. This recently discovered section consists of thin-bedded, greybrownish turbiditic marls and limestones laid down in rhythmic alterations. Excavations of the marl beds have yielded a poorly-preserved, but rich cephalopod fauna. Furthermore, Eutrephoceras ex gr. boissieri has been identified here, and this is the first record of Cretaceous nautiloids from the Mecsek Mountains.
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Waris, Waris. "PENDIDIKAN DALAM PERSPEKTIF URHANUDDIN AL-ISLAM AZ-ZARNUJI." Cendekia: Jurnal Kependidikan dan Kemasyarakatan 13, no. 1 (June 1, 2015): 69. http://dx.doi.org/10.21154/cendekia.v13i1.238.
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Abstract: Big Moslem scholar who live in town of Zarnuj regional of Iraq, now this Afganistan have complete name of Burhanuddin Al-Islam Az-Zarnuji. He live during with Ridha Ad-Din An-Naisaburi between year 500-600 H, while pass awaying him there is telling year 591 H besides year 593 H. Education concept told by Az-Zarnuji by monumental poured in his masterpiece of Ta’Limul Muta’Allim. According to that education he cover five factor that is target of education, educated (student), educator (teacher), appliance (medium) education and environment. While education which is have Islam nuance to. in the masterpiece discussed in 13 section. which by he concluded into three big shares. that is division of science, target and intention learn, and also study method. تايلاولا ىدحا جونرز ةنيدم في نكسو ،يجونرزلا ملاسلإا نيدلا ناهرب وه يجونرزلا ماملإل لماكلا مسلاا ـه600 - 500 ةنسلا للاخ يروباسينلا نيدلا ىضر لماعلا وه رصاعو .ناتسناغفأ في نلآا عقتو ،قارعلا في . “ مّ لعتلما ميلعت “ فورعلما هباتك في ةيبترلا نع هميهافمو هراكفأ مّ دق .ـه 593 ةنس ليقو ـه591 ةنس فيوتو سّ ردلما )3 ،بلاطلا )2 ،ةيبترلا فادهأ )1 : رصانع ةسخم ىلع تلمتشا ةيبترلا نأ يجونرزلا ماملإا ىأر في ةروكذمف – مّ لعتلما ميلعت باتك في – ةيملاسلإا ةيبترلا تاعوضوم امأ .ةئيبلا )5 ،لئاسولا )4 ،مّ لعلما وأ.ميلعتلا قرطو ،ملعتلا اياونو فادهأو ،ملعلا ماسقأ يه ،باوبأ 3 في فلؤلما اهصلختسا ، لاصف 13
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Tóth, János. "Mozgó-képek: szisztematikus áttekintés a muszlimok médiareprezentációjáról kortárs szociológiai kutatásokban." Információs Társadalom 15, no. 3 (May 29, 2017): 18. http://dx.doi.org/10.22503/inftars.xv.2015.3.2.
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Ebben a tanulmányban arra a kérdésre keressük a választ, hogy a főképp nyugati tudományos kutatói környezetben megtermelt, kortárs tudományos eredményekben hogyan jelenik meg a média és a muszlimok viszonya, valamint, hogy ezen eredmények létrejöttének körülményeiben milyen hasonlóságokat és eltéréseket lehet felfedezni. Az Európát az IS közép-keleti tevékenysége, a szíriai polgárháború és más okok miatt az elmúlt években egyre nagyobb mértékben érinti a muszlim bevándorlás jelensége. Ez, továbbá a bevándorló muszlimok és a többségi nemzet közti interakciók problémái indokolttá teszik ezeknek a közelmúltbeli tudományos eredményeknek részletesebb, a tematizáció, a geográfiai eloszlás, a vizsgált minták és a mintaméret, az adott kutatáshoz elnyert támogatások és más egyéb releváns szempontok szerinti metaelemzését. A következőkben bemutatjuk a kitűzött célok megvalósítását egy N=160 szakcikkből álló mintán, a muszlimokról szóló kutatások (N=33) kiválogatását követő szisztematikus analízis lefolytatásával és a média szerepét és hatását vizsgáló tematikus elemzéssel. Azt találtuk, hogy a vizsgált mintán belül a médiában megjelenő muszlim-képek három fő típusa azonosítható: Az erőszakot individuális vagy állami szinten alkalmazó entitás, az erőszakot elszenvedő áldozat, illetve a „nyugattal” kulturálisan és viselkedésileg szembenálló idegen.
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Moving Images: a Systematic Analysis on the Media Representation of Muslims in Recent Sociological Research
In this study, we are looking for an answer to the question of how the relation of media and muslims is represented in contemporary scientific results, produced mostly in a western research environment and, furthermore, of what similarities and differences can be shown between the circumstances characterizing the emergence of these results. As a result of IS’s activities in the Middle East, of the current civil war in Syria and of other causes, Europe is increasingly affected by the phenomenon of muslim immigration. This, as well as the problematics of national majority-Muslim minority interactions make the goal of conducting a meta-analysis of recently published results reasonable, focusing on issues of thematization, geographical distribution, analyzed samples and sample sizes as well as on grants obtained by the authors for a specific research. In the following, we realize our research objectives through conducting a systematic analysis on a section (N=33) of a larger (N=160) sample of peer-reviewed articles, and by a thematic analysis of the same section focusing on the role and influence of various media. We found that within the sample, images of Muslims in the media can be categorized in three main types: An entity using violence at the individual or state level, a victim of violence, and an outsider culturally or behaviorally in defiance of the West.
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Hankinson, R. J. "The Sceptical Inquirer." History of Philosophy and Logical Analysis 23, no. 1 (September 8, 2020): 74–99. http://dx.doi.org/10.30965/26664275-02301007.
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Abstract This article treats of whether scepticism, in particular Pyrrhonian scepticism, can be said to deploy a method of any kind. I begin by distinguishing various different notions of method, and their relations to the concept of expertise (section 1). I then (section 2) consider Sextus’s account, in the prologue to Outlines of Pyrrhonism, of the Pyrrhonist approach, and how it supposedly differs from those of other groups, sceptical and otherwise. In particular, I consider the central claim that the Pyrrhonist is a continuing investigator (section 3), who in spite of refusing to be satisfied with any answer (or none), none the less still achieves tranquillity, and whether this can avoid being presented as a method for so doing, and hence as compromising the purity of sceptical suspension of commitment (section 4). In doing so, I relate—and contrast—the Pyrrhonists’ account of their practice to the ‘Socratic Method’ (section 5), as well as to the argumentative practice of various Academics (section 6), and assess their claim in so doing to be offering a way of instruction (section 7). I conclude (section 8) that there is a consistent and interesting sense in which Pyrrhonian scepticism can be absolved of the charge that it incoherently, and crypto-dogmatically, presents itself as offering a method for achieving an intrinsically desirable goal.
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Csuvár, Ádám, Gyöngyi Bánkuti, Balázs Cseh, Szabolcs Simon, and József Varga. "A GPI, az SNBI és a HDI alternatív gazdasági mutatók elméleti áttekintése." Acta Scientiarum Socialium, no. 49 (November 28, 2019): 17–25. http://dx.doi.org/10.33566/asc.2528.
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The paper describes some of the main economic indicators such as the Genuine Progress Indicator (GPI), Sustainable Net Benefit Index (SNBI) and the Human Development Index (HDI) that have been intended to replace or supplement Gross Domestic Product. Based on our analysis, we conclude that none of the indicators is still able to replace GDP because of the difficulties in data collection and the lack of sufficient objectivity in the types of information used. Meanwhile, each indicator draws attention to important trends that are not visible from GDP so they can provide useful signals for building and evaluating policies. The study was created for the Economics Seminar of Kaposvár (KAKTUSZ) which is organized annually by the Kaposvár University. It is closely related to the paper by Varga et al. (2018) titled “Theoretical overview of MEW and ISEW alternative economic indicators” (in the present issue) and can be conceived as a continuation of that.
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Grace, R. F., and V. J. Roach. "Caesarean Section in a Patient with Paramyotonia Congenita." Anaesthesia and Intensive Care 26, no. 5 (October 1998): 534–37. http://dx.doi.org/10.1177/0310057x9802600511.
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This case report details spinal anaesthesia for an elective caesarean section in a patient with the rare condition of paramyotonia congenita. There are few case reports of anaesthesia in this condition and none in the Australian anaesthetic literature. This case highlights the need for the avoidance of hypothermia and depolarizing muscle relaxants, the safety of spinal anaesthesia and a conservative approach to the management of plasma potassium concentration. The subsequent review outlines the current literature and discusses other issues involved in the anaesthetic management of this disorder.
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Begum, Tahera, M. Jalal Uddin, and Ishrat Jabin. "Caesarean Section Without Indwelling Catheter." Chattagram Maa-O-Shishu Hospital Medical College Journal 14, no. 1 (April 4, 2015): 34–35. http://dx.doi.org/10.3329/cmoshmcj.v14i1.22878.
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Background: Many studies were conducted worldwide on the subject but there is none in Chittagong. To get our experience we had conducted the study. Methods: It was an experimental study. 70 cases were conveniently selected under certain inclusion and exclusion criteria. Cases were managed by the obstetricians unrelated to the study. All cases were meticulously observed by the investigators and findings were instantly recorded. All data were manually managed. A discussion was made and conclusion was drawn. Results: Total 70 cases were studied. 35 primae and 35 multipara. Mean age was 27 years +2.3 . All were literate and 86% were housewives. Cases were without medical, surgical complications and were uneventfully managed. First voiding time was 4.28 hours +0.45. 07% cases were evacuated with plain catheter after 7 hours for pain and bladder distention. Average hospital stay 2.3 days. There was no occurrence of urinary tract infection. Conclusion: Indwelling catheter should not be used unless it is strongly indicated. DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22878 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 34-35
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Woschko, Dennis, Simon Millan, Muhammed-Ali Ceyran, Robert Oestreich, and Christoph Janiak. "Synthesis of a Chiral 3,6T22-Zn-MOF with a T-Shaped Bifunctional Pyrazole-Isophthalate Ligand Following the Principles of the Supramolecular Building Layer Approach." Molecules 27, no. 17 (August 23, 2022): 5374. http://dx.doi.org/10.3390/molecules27175374.
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The metal–organic framework (MOF) [Zn(Isa-az-tmpz)]·~1–1.5 DMF with the novel T-shaped bifunctional linker 5-(2-(1,3,5-trimethyl-1H-pyrazol-4-yl)azo)isophthalate (Isa-az-tmpz) was obtained as a conglomerate of crystals with varying degrees of enantiomeric excess in the chiral tetragonal space groups P43212 or P41212. A topological analysis of the compound resulted in the rare 3,6T22-topology, deviating from the expected rtl-topology, which has been found before in pyrazolate-isophthalate-functionalized MOFs using the supramolecular building layer (SBL) approach. 3,6T22-[Zn(Isa-az-tmpz)]·~1–1.5 DMF is a potentially porous, three-dimensional structure with DMF molecules included in the corrugated channels along the a and b-axis of the as synthesized material. The small trigonal cross-section of about 6 × 4 Å (considering the van der Waals surface) prevents the access of N2 and Ar under cryogenic conditions. After activation, only smaller H2 (at 87 K) and CO2 (at 195 K) are allowed for gas uptakes of 2 mmol g–1 and 5.4 mmol g–1, respectively, in the ultramicroporous material, for which a BET surface area of 496 m2·g–1 was calculated from CO2 adsorption. Thermogravimetric analysis of the compound shows a thermal stability of up to 400 °C.
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Mo, Matthew, Mike Roache, Deb Lenson, Heidi Thomson, Mitchell Jarvis, Natalie Foster, Angie Radford, Lorraine Oliver, Damon L. Oliver, and Joss Bentley. "Congregations of a threatened species: mitigating impacts from Grey-headed Flying-fox Pteropus poliocephalus camps on the Batemans Bay community." Australian Zoologist 41, no. 1 (January 2020): 124–38. http://dx.doi.org/10.7882/az.2020.021.
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Flying-fox camps in urban areas are a contentious wildlife management issue. Since 2012, Grey-headed Flying-foxes Pteropus poliocephalus have regularly occupied two camps in Batemans Bay, New South Wales (NSW). At one site, the Water Gardens, impacts on adjacent residents and businesses occur when animals roost near the reserve boundaries. During March–July 2016, a large influx of flying-foxes arrived, causing the camps to spread into neighbouring residential, recreational and industrial areas. Prior to this, impacts had been mitigated through vegetation clearing to create buffer zones and residential subsidies for mitigation equipment and services. The influx warranted additional measures such as a dispersal program and further vegetation removal, which were expedited by the Commonwealth Government granting a National Interest Exemption under section 158 of the Environment Protection and Biodiversity Conservation Act 1999 and the NSW Government committing $2.5 million in funding towards the new measures. These measures moved flying-foxes from key conflict areas but also coincided with flying-fox numbers reducing as local blossom diminished. Ongoing community engagement played an important role in building community resilience to live with this threatened species, which is vital considering that Batemans Bay will likely continue to be an important area for flying-foxes.
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Chowdhury, Liza, and Ishrat Jahan. "Cesarean Section without Urethral Catheterization." Journal of Armed Forces Medical College, Bangladesh 11, no. 1 (December 15, 2016): 3–6. http://dx.doi.org/10.3329/jafmc.v11i1.30658.
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Introduction: Urethral catheterization is done as a routine procedure in cesarean section. It is associated with great discomfort, high incidence of urinary tract infection, delayed ambulation and longer hospital stay.Objectives: To determine the feasibility and safety of cesarean section without urethral catheterization.Materials and Methods: A prospective, observational study was carried out from April 2012 to March 2013, in the Department of Obstetrics and Gynaecology, CMH Dhaka and IBN Sina Hospital Dhaka among 65 patients who had undergone cesarean section without catheterization. There were some limitations of this study. We had excluded previous cesarean from our study, so the results of this study cannot be generalized.Results: Firs void discomfort was not significantly associated without the use of indwelling catheter. Hospital stay was shorter (94% was discharged on 3rd post operative day). None of the patients had bladder injury. Mean duration of surgery was 45 minutes (44%) and ambulation time 11-14 hours (60%). Average estimated blood loss was 500 ml (41%) and time of 1st voiding was 5-8 hrs (58%). Need for catheterization was significantly low (3%).Conclusion: Cesarean section can be done safely without urethral catheterization with reduced morbidities.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 3-6
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Kotosz, Balázs. "A GDP, a HDI, a GNH és az OECD indikátorrendszere mint a fenntartható fejlődés indikátorai." Jelenkori Társadalmi és Gazdasági Folyamatok 8, no. 1-2 (January 1, 2013): 33–38. http://dx.doi.org/10.14232/jtgf.2013.1-2.33-38.
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Sustainable development has been an important focus of current researches. To be able to test the theories, to develop goals, and to control their fulfillment we need measurement. The three main fields of sustainable development (economic, societal and ecological) have a series of indicators, but these indicators are not always applicable to achieve the above-mentioned goals. In the paper, we survey the requirements of the indicators absed on a wide-range literature, whether they are real and consistent ones, their possible weights in the three fields. After theoretical part, we analyze some wellknown measure to show that even these measures can be criticized. We conclude that none of the above mentioned measures are perfect ones, and sometimes the most criticized measures show better performance.
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Hamar, Balázs, Balázs Börzsönyi, Nándor Ács, Tibor Glasz, and Zsolt Melczer. "Ritka hasűri vérzés a vena lienalis ágrendszeréből várandósság alatt." Orvosi Hetilap 163, no. 8 (February 20, 2022): 328–32. http://dx.doi.org/10.1556/650.2022.32345.
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Összefoglaló. Az „akut has”, mint kórkép, a várandósság során mind diagnosztikailag, mind terápiásan nagy kihívást jelent a szülész számára a megváltozott anatómiai viszonyok és a képalkotó eljárások korlátozott használhatósága miatt. Közleményünkben bemutatjuk egy harmadik trimeszterbeli gravida hasi vérömlenyének az esetét, melynek vérzésforrása irodalmi ritkaság, a vérzés típusát a felkereshető irodalomban még nem írták le terheseknél. Az esettanulmány megírása a páciens orvosi dokumentációi és az ellátásában résztvevő klinikusok, patológusok leletei és beszámolói alapján történt. A várandósságának 33. hetében járó gravida akut hasi tünetegyüttessel jelentkezett klinikánkon, anamnéziséből trauma kizárható volt. Az anya romló kardiorespiratorikus állapota miatt sürgősségi császármetszéssel élő, koraszülött magzatot segítettünk világra. A műtét során kb. 1500 ml vért találtunk a hasüregben, melynek okát általános sebész bevonásával kerestük. Aktív vérzésforrásként a lép ereinek területéről vénás jellegű szivárgó vérzést találtunk, ezért splenectomia mellett döntöttünk. Az eltávolított szervkomplexum teljes szövettani feldolgozása helyenként a kisebb léphilusi vénaágak izomfalának felrostozódását és fokozatos eltűnését igazolta, a patológus a vérzés okát a meggyengült érfal endothelen keresztüli vérszivárgásának véleményezte, definitív érfalszakadásra utaló elváltozás nem volt azonosítható. A haemoperitoneum várandósság alatt kifejezetten ritka kórkép, azonban mortalitása mind az anyára, mind a magzatra nézve rendkívül magas. Irodalmi adatok alapján a vérzésforrás leggyakrabban a kismedencei szervek területén jelentkezik. Ritkán a lépartéria aneurysmájának rupturája is előfordul terhességben, a lépvénás eredetű vérzés viszont irodalmi ritkaságnak számít, és az összes feldolgozott és közölt esetben az ér szakadásos sérülése volt a fő ok, az esetünkben leírt, ismeretlen etiológiájú, érfalvesztéses hemorrhágiát sehol nem említik. A várandósunk ellátásánál ellátásánál kulcsfontosságú volt a gyorsan elvégzett exploratív laparotomia, mely a kórkép okát felderítette és megszüntette, lehetővé téve az anya és gyermeke túlélését és felépülését. Esetünk rámutat arra, hogy a várandóssági hasűri vérömlenyek kóroktana akár irodalmi ritkaságokat is rejthet, azaz a pontos ok kiderítésével, lumenes vérzésforrás keresésével nem szabad szükségtelen időt veszteni az édesanya és gyermeke életmentő ellátásának rovására. Orv Hetil. 2022; 163(8): 328–332. Summary. Acute abdomen during pregnancy is a major challenge for physicians, due to the altered anatomical conditions and the limited use of medical imaging. We present a pregnant woman with a rare form of abdominal bleeding. This case study is based on the patient’s medical documentations and interviews with her physicians. A woman in the 33rd week of her pregnancy was admitted to our department with acute abdomen, trauma was ruled out. Due to the deteriorating cardiorespiratory status we performed an emergency caesarean section delivering a living premature newborn. A general surgeon was present, and 1500 ml of blood was evacuated from the abdomen. Active venous type bleeding was present from the splenic vessels, therefore we performed a splenectomy. The histopathological analysis of the whole organ complex showed that the media layer segmentally and progressively disappeared in the splenic hilar veins, giving rise to the high probability that the bleeding was caused by a diathesis-type leakage through the endothelium and to the weakened media layer in the absence of a luminal-type vessel rupture. Hemoperitoneum during pregnancy is an exceptionally rare condition, however its mortality rate is high both for the mother and the fetus. The bleeding usually originates from the pelvis. On rare occasions the bleeding occurs from the splenic vessels although most of them are arterial bleedings from an aneurysm.In our case the emergency laparotomy was essential for the correct diagnosis and the treatment, which resulted in saving and recovering both the mother and the fetus. Orv Hetil. 2022; 163(8): 328–332.
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Gurung, Tara, Sangeeta Shrestha, Ujjwal Basnet, and Amirbabu Shrestha. "Awareness with Recall in General Anesthesia undergoing Cesarean Section." Nepal Journal of Obstetrics and Gynaecology 13, no. 1 (November 12, 2018): 18–22. http://dx.doi.org/10.3126/njog.v13i1.21611.
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Aims: To determine the incidence of awareness with recall in parturient undergoing cesarean section under general anesthesia in Paropakar Maternity and Women’s Hospital.Methods: Retrospective observational cohort study of the patients who underwent cesarean section under general anesthesia from April mid 2014 to April mid 2017 (Baishakh 2071 to Chaitra 2073 BS). Awareness questionnaires filled up through the modified Brice interview.Results: A total of 162 patients underwent Cesarean Section under general anesthesia and138 were included in the study. None of them had awareness and six patients had a dream.Conclusion: No awareness with recall found and prospective study is required to determine the condition.
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Varga, Gyorgy, and Ricardo Dias de Oliveira Brito. "The Cross-Section of Expected Stock Returns in Brazil." Brazilian Review of Finance 14, no. 2 (June 27, 2016): 151. http://dx.doi.org/10.12660/rbfin.v14n2.2016.60916.
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In a sample of the Brazilian stock market from 1999 to 2015, this paper shows that the book-to-market and momentum of individual firms capture some of the cross-sectional variation in average stock returns, while the market β and size do not play a role. The positive relation of cross-section of returns with book-to-market is more evident earlier, while the positive relation with momentum is stronger later in the sample. However, because none of these characteristics show explanatory power for all the subsamples studied, we are not fully convinced that they capture fundamental risk factors.
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Daly, Garry. "The distribution and status of the Giant Burrowing Frog Heleioporus australiacus in the Shoalhaven region of south-eastern New South Wales." Australian Zoologist 40, no. 2 (December 2019): 256–71. http://dx.doi.org/10.7882/az.2018.011.
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Surveys were conducted for the Giant Burrowing Frog Heleioporus australiacus within 50 km of Nowra, on the south coast of New South Wales using a variety of methods. Thirty-eight 250 m transects were surveyed at night for 30 min each and 0–12 adult frogs were detected during these searches. Additional diurnal searches for tadpoles proved to be the most efficient method to detect the species and locate breeding sites. Of 102 sites surveyed, fragmented populations were found at 27 by the presence of tadpoles and adult frogs. The vegetation at these sites was woodland and open forest with a dense shrublayer of heath, but was often ecotonal. Forty-six percent of the sites were within 100 m of cliff edges/waterfalls. The lithology of sites where the frog was found varied from Hawkesbury, Nowra and Snapper Point sandstones. The exception was a population south of Ulladulla that occurs on undifferentiated sediments, but at that site exposed sandstone and a sandy overlay was present. The location of tadpoles indicated that adults were highly selective of the section of drainage line used for breeding. Often these sites consisted of a few small pools in non-perennial creeks. Breeding behaviour was associated with late summer and autumn rain, but in some sites reproduction did not occur annually. Based on distribution and habitat preference, the region has five discrete populations. Urban development has fragmented populations.
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Kovács, Kata, Enikő Szakmár, Ünőke Méder, Márton Kolossváry, Zsolt Bagyura, Lilla Lamboy, Zsuzsanna Élő, Attila Szabó, Miklós Szabó, and Ágnes Jermendy. "Terápiás hypothermia alkalmazása az asphyxiás újszülöttek kezelésében – egy hazai neonatológiai centrum eredményei." Orvosi Hetilap 158, no. 9 (March 2017): 331–39. http://dx.doi.org/10.1556/650.2017.30661.
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Abstract: Introduction and aim: We aimed to analyze patient characteristics of term neonates with hypoxic-ischemic encephalopathy treated with hypothermia at the 3rd level Neonatal Intensive Care Unit of the 1st Department of Pediatrics, Semmelweis University. Method: We conducted a retrospective cohort analysis between 2013–2015, including 97 asphyxiated neonates with HIE who received hypothermia treatment, using our in-house developed novel registry database. Results: 59.8% of neonates were born with Cesarean section and the first blood gas analysis showed a pH of 7.0 ± 0.2, pCO2 55.9 ± 27.3 mmHg, base deficit 16.7 ± 7.2 mmol/l, and lactate levels of 13.3 ± 4.7 mmol/l (x ± SD). Hypothermia treatment was started during neonatal transport in 93.7% of the cases, at 2.5 ± 0.3 hours of age. Multiorgan failure associated with the perinatal asphyxia was present in 83.2% of the patients. Patients received intensive therapy for a median of 10.8 days, 61.3% of neonates were discharged home directly, 32.2% required further hospital treatment, and 6.5% died. Conclusion: Our novel registry database allowed for a quick, user-friendly and time-efficient analysis of patient characteristics in neonates with HIE. This registry could aid institutional audit work and prospective clinical data collection. Orv. Hetil., 2017, 158(9), 331–339.
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Wenner, Lawrence A. "Anniversaries, Trajectories, and the Challenges for the Communication of Sport." Communication & Sport 5, no. 4 (June 5, 2017): 399–406. http://dx.doi.org/10.1177/2167479517711955.
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This editorial essay by Communication and Sport Editor-in-Chief Lawrence Wenner is drawn from his March 31, 2017, keynote address honoring the 10th meeting of the Communication and Sport Summit convened by the International Association for Communication and Sport (IACS) in Scottsdale, AZ. The first section focuses on anniversaries, noting recent anniversaries of key works, the “coming of age” of the disciplinary area and the publication changes ahead for Communication and Sport as the journal enters its fifth year. The second section considers questions about disciplinary coherence for the study of communication and sport and points to key role that IACS can play in reconciling three distinct dispositions at play in scholarship: (1) media, sports, and society disposition; (2) sport communication as profession disposition; and (3) communication studies and sport disposition. The third section considers key challenges ahead for the study of communication and sport, calling attention to the need for the field to think globally, to avoid ethnocentrism, to grow and embrace an international scholarly agenda that reaches beyond the confines of the west, and to work to diversify and become an inclusive and interdisciplinary community of scholars.
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Schiszler, Bence, Attila Pandur, Gábor Priskin, Balázs Tóth, József Betlehem, and Balázs Radnai. "„Dönts és siess!” A prehospitális ellátók szerepe az időveszteség csökkentésében stroke-iránydiagnózisú betegek esetén." Orvosi Hetilap 163, no. 7 (February 13, 2022): 279–87. http://dx.doi.org/10.1556/650.2022.32351.
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Összefoglaló. Bevezetés: A stroke-betegek ellátásában arra kell törekedni, hogy a tünetek jelentkezését követően minél előbb a szakmai centrumba kerüljön a beteg. Célkitűzés: Kutatásunkban a terápiás időablak tarthatósága céljából vizsgáltuk, hogy mely tényezők bírnak hatással a prehospitális ellátás időtartamaira. Módszer: Keresztmetszeti, kvantitatív kutatásunkhoz az adatgyűjtést két magyarországi város mentőállomásán, orvosi kompetenciával rendelkező (eset-, rohamkocsi) és orvosi kompetenciával nem rendelkező (mentőgépkocsi) mentőegység szintjén végeztük 2017-es adatok feldolgozásával olyan betegek körében, akiknek a mentőegység általi iránydiagnózisa stroke volt (n = 220). Vizsgáltuk, hogy a mentőegységek által elvégzett vizsgálatok, a tapasztalt tünetek, a terápiás időablakon belüliség miként befolyásolta a prehospitális időket. Az adatfeldolgozást SPSS 26.0 statisztikai programmal végeztük. Az elemzéshez leíró statisztikát, χ2-próbát, F-próbát és T-próbát alkalmaztunk. Eredmények: Megállapítottuk, hogy az alkalmazott score-rendszer vizsgálati elemei közül, ha aphasia volt észlelhető a betegnél, úgy szignifikánsan meghosszabbodott a helyszínen töltött idő (p = 0,003). A gyors ABCDE-betegvizsgálat D-lépésében kötelező a betegnél a vércukorszintmérés, ugyanakkor ez mintánk 25,45%-ában elmaradt. A helyszíni műszeres vércukorszintmérés hatással van a prehospitális késés alakulására az orvosi kompetencia nélküli egységek vonatkozásában (p<0,001). Következtetés: A helyszínen töltött idő az emelt szintű mentőegységek esetében hosszabb, mint az alacsonyabb szintű egységeknél. Következtetésként levonhatjuk, hogy a motoros vagy szenzoros aphasia nem befolyásolja a terápiát, pusztán a stroke-diagnózis valószínűségét növelő egyik tünet, így a helyszíni idő emiatti megnyúlása mindenképpen kerülendő, amire javasolt a továbbképzések alkalmával is felhívni az ellátók figyelmét. Az orvosi kompetencia nélküli egységek esetében beavatkozást igényel a műszeres vércukormérés időrabló hatásának csökkentése, hiszen látható, hogy az orvosi kompetenciával rendelkező egységeknél ez a vizsgálat nem jelenik meg mint késést okozó tényező. Orv Hetil. 2022; 163(7): 279–287. Summary. Introduction: When treating stroke patients, the aim should be to get the patient to a specialist stroke centre as soon as possible. Objective: In our study, in order to be able to stay within the therapeutic window, we investigated which variables affect the time period of prehospital treatment. Method: For our cross-sectional quantitative study, we gathered data from two ambulance stations in Hungary, comparing the competence of physician and non-physician units. We processed information from 2017 regarding patients whose initial diagnosis was stroke (n = 220). We examined how investigations by the ambulance unit, symptoms experienced and therapeutic time window have affected prehospital times. As for the statistic software, we used SPSS 26.0. The analysis was conducted by performing χ2 test, F-test and T-test. Results: We identified that if the aphasia component of the used score system was positive, the on-scene time increased significantly (p = 0.003). In the D section of the rapid ABCDE assessment, it is mandatory to measure the blood glucose level of the patient, however, in our sample it was omitted in 25.45% of the cases. We identified that on-site blood glucose measurement has an effect on prehospital delay for non-physician units (p<0.001). Conclusion: We found that the on-scene time is longer for physician units than for non-physician units. We concluded that motor or sensory aphasia does not affect the therapy, it is just one of the symptoms that can increase the likelihood of stroke diagnosis, therefore prolonging time for assessing aphasia in the field should be avoided. Moreover, it is recommended to make care providers aware of this during training sessions. Improvements are required in non-physician units to reduce the time consumed by blood glucose measurement, as it has been shown that within physician units this test does not appear to be a delay-causing factor. Orv Hetil. 2022; 163(7): 279–287.
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Roy, Priyankur, Lakshmanan Jeyaseelan, and Jose Ruby. "Respiratory Morbidity in Term Infants delivered by Elective Cesarean Section at a Tertiary Care Hospital in India: A Randomized Controlled Trial." Journal of South Asian Federation of Obstetrics and Gynaecology 9, no. 4 (2017): 312–17. http://dx.doi.org/10.5005/jp-journals-10006-1520.
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ABSTRACT Objectives (1) To investigate the association between term elective cesarean sections and neonatal respiratory morbidity and the importance of timing of the cesarean. (2) To assess the maternal morbidity when emergency lower segment cesarean section (LSCS) was required. Participants All women with singleton term (37—41 + 6 weeks) pregnancies and planned for elective cesarean section in Christian Medical College, Vellore, India. Outcome measures The primary outcome measures were neonatal morbidities such as transient tachypnea of newborn (TTN) and respiratory distress syndrome (RDS). The secondary outcome measures were emergency cesarean section and maternal morbidities such as scar dehiscence, urinary tract infection (UTI), endometritis, peritonitis, and hemoperitoneum in the mother. Results The percentage of TTN in the infants in group I was 1.3% while there were none in group II. No infants were diagnosed to have RDS. Out of the 150 women who were planned for elective cesarean section, 55 women underwent emergency cesarean section. Among this, 19 (25.3%) of women were from group I as compared with 36 (48.0%) in group II. The difference in proportion between the two groups was –22.7 [95% confidence interval (CI): –37.7, –7.7], which was statistically significant (p < 0.01). The incidence of scar dehiscence, UTI, endometritis, and hemoperitoneum in the mothers of group II was marginally higher than that in the mothers of group I. There was one woman with peritonitis in group I while none was reported in the other group. All the maternal morbidities occurred to women who underwent emergency cesarean section. Out of the 19 women in group I and 36 women in group II who underwent emergency cesarean section, 1 (5.3%) and 6 (16.7%) women had morbidities. Conclusion Women requiring elective cesarean section can safely be done between 37 and 39 weeks with no further significant increase in the rates of neonatal morbidity such as TTN and RDS. How to cite this article Roy P, Jeyaseelan L, Ruby J, Garg R. Respiratory Morbidity in Term Infants delivered by Elective Cesarean Section at a Tertiary Care Hospital in India: A Randomized Controlled Trial. J South Asian Feder Obst Gynae 2017;9(4):312-317.
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Majoros, Attila, Miklós Romics, Aida Ali, Antal Hamvas, Péter József Molnár, Attila Keszthelyi, and Péter Nyirády. "Hiperaktív (túlműködő) húgyhólyag kezelése botulinumtoxin-A-terápiával." Orvosi Hetilap 162, no. 36 (September 5, 2021): 1459–65. http://dx.doi.org/10.1556/650.2021.32288.
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Összefoglaló. Bevezetés: A hiperaktív húgyhólyag szindróma népbetegség mértékű probléma, mely jelentősen rontja az érintettek életminőségét. A konzervatív, gyógyszeres kezelés eredménytelensége esetén másodvonalbeli terápiaként a minimálisan invazív botulinumtoxin intradetrusor injekció javasolható. Célkitűzés: A nem neurogén eredetű hiperaktív (túlműködő) hólyag szindróma miatt végzett botulinumtoxin intradetrusor injekciós kezelés hatékonyságának, biztonságosságának felmérése saját beteganyagunkon, és annak vizsgálata, hogy az eredményességet befolyásolják-e a vizsgált preoperatív paraméterek. Módszer: Egy retrospektív vizsgálat során összegyűjtöttük 33, intradetrusor BOTOX® injekción átesett betegünk perioperatív adatait (életkor, testtömegindex, kísérő betegségek, anatómiai eltérések, korábbi műtétek, panaszok, urodinámiás leletek). Az eredményesség és a posztoperatív komplikációk felmérése a betegdokumentáció, telefoninterjúk, kérdőívek segítségével történt. A statisztikai analízis során kapott eredményeket p<0,05 esetén tekintettük szignifikánsnak. Eredmények: Műtét után jelentős szövődményt nem tapasztaltunk (p>0,05), 6 betegnél észleltünk hólyagkatéterezést nem igénylő residuumot (p = 0,024). Az urgencia, ’urge’ incontinentia, pollakisuria, nycturia előfordulása és mértéke, a vizeletincontinentia miatti betéthasználat szignifikánsan csökkent (p<0,01), az életminőség, az általános egészségi állapot mutatói szignifikánsan javultak a műtét után (p<0,001). A perioperatív faktorok és a posztoperatív eredményesség (72,7%) között szignifikáns kapcsolat nem igazolódott (p>0,05). Megbeszélés: A tüneti javulás eredményei megegyeznek az irodalmi adatokkal, a nemzetközi publikációkban közölt eredményekhez képest is jobb mellékhatásprofil pedig az óvatosabb betegszelekcióval és részletesebb kivizsgálással magyarázható. Következtetés: A botulinumtoxin-A-terápia hatékony, biztonságos, minimálisan invazív kezelése a terápiarefrakter hiperaktív hólyag szindrómának. Nem sikerült olyan preoperatív faktort azonosítanunk, mely szignifikáns hatással bírna a kezelés eredményességének előrejelzésére. Orv Hetil. 2021; 162(36): 1459–1465. Summary. Introduction: Overactive bladder syndrome is an endemic phenomenon, which has a significant impact on the quality of life. In cases where conservative treatment fails, intradetrusor onabotulinumtoxinA injection can be used as second-line therapy. Objective: To assess the safety and efficacy of onabotulinumtoxinA treatment in the management of non-neurogenic detrusor overactivity among our patients. Also, to examine the influence of perioperative factors on the effects of the efficacy. Method: We have retrospectively collected the perioperative data of 33 patients treated with intradetrusor BOTOX®. The assessment of the efficacy and complications was done by the examination of patient files and questionnaires. The results obtained during the statistical analysis were considered significant for p<0.05. Results: We have not experienced notable complications after the procedures. Only 6 patients had residual urine (p = 0.024), none of them needed to be catheterized. We have observed significant decrease in the incidence of frequency, nocturia, urgency and incontinence, just as in the number of pads needed daily (p<0.01). Quality of life and general health were significantly improved (p<0.001). We have not found any significant connection between preoperative factors and efficacy (72.7%). Discussion: Our results considering the relief of symptoms are well in line with international data. The fact that our rate of complications is – in international comparison – outstanding can be explained by a more careful patient selection and thorough preoperative assessment. Conclusion: OnabotulinumtoxinA therapy is a safe and effective solution of therapy-refractory overactive bladder. We could not identify any perioperative factor to predict postoperative efficacy of therapy. Orv Hetil. 2021; 162(36): 1459–1465.
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Versluis, JM, EA Rozeman, AM Menzies, ILM Reijers, O. Krijgsman, EP Hoefsmit, BA van de Wiel, et al. "L3 Update of the OpACIN and OpACIN-neo trials: 36-months and 24-months relapse-free survival after (neo)adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma patients." Journal for ImmunoTherapy of Cancer 8, Suppl 2 (October 2020): A2.1—A2. http://dx.doi.org/10.1136/jitc-2020-itoc7.3.
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BackgroundBefore adjuvant checkpoint inhibition the 5-year overall survival (OS) rate was poor (<50%) in high-risk stage III melanoma patients. Adjuvant CTLA-4 (ipilimumab, IPI) and PD-1 (nivolumab, NIVO, or pembrolizumab) blockade have been shown to improve relapse-free survival (RFS) and OS (latter only for IPI so far). Due to a broader immune activation neoadjuvant therapy with checkpoint inhibitors might be more effective than adjuvant, as suggested in preclinical experiments. The OpACIN trial compared neoadjuvant versus adjuvant IPI plus NIVO, while the subsequent OpACIN-neo trial tested three different dosing schedules of neoadjuvant IPI plus NIVO without adjuvant therapy. High pathologic response rates of 74–78% were induced by neoadjuvant IPI plus NIVO. Here, we present the 36- and 24-months RFS of the OpACIN and OpACIN-neo trial, respectively.Materials and MethodsThe phase 1b OpACIN trial included 20 stage IIIB/IIIC melanoma patients, which were randomized to receive IPI 3 mg/kg plus NIVO 1 mg/kg either adjuvant 4 cycles or split 2 cycles neoadjuvant and 2 adjuvant. In the phase 2 OpACIN-neo trial, 86 patients were randomized to 2 cycles neoadjuvant treatment, either in arm A: 2x IPI 3 mg/kg plus NIVO 1 mg/kg q3w (n=30), arm B: 2x IPI 1 mg/kg plus NIVO 3 mg/kg q3w (n=30), or arm C: 2x IPI 3 mg/kg q3w followed immediately by 2x NIVO 3 mg/kg q3w (n=26). Pathologic response was defined as <50% viable tumor cells and in both trials centrally reviewed by a blinded pathologist. RFS rates were estimated using the Kaplan-Meier method.ResultsOnly 1 of 71 (1.4%) patients with a pathologic response on neoadjuvant therapy had relapsed, versus 16 of 23 patients (69.6%) without a pathologic response, after a median follow-up of 36 months for the OpACIN and 24 months for the OpACIN-neo trial. In the OpACIN trial, the estimated 3-year RFS rate for the neoadjuvant arm was 80% (95% CI: 59%-100%) versus 60% (95% CI: 36%-100%) for the adjuvant arm. Median RFS was not reached for any of the arms within the OpACIN-neo trial. Estimated 24-months RFS rate was 84% for all patients (95% CI: 76%-92%); 90% for arm A (95% CI: 80%-100%), 78% for arm B (95% CI: 63%-96%) and 83% for arm C (95% CI: 70%-100%). Baseline interferon-γ gene expression score and tumor mutational burden predict response.ConclusionsOpACIN for the first time showed a potential benefit of neoadjuvant IPI plus NIVO versus adjuvant immunotherapy, whereas the OpACIN-neo trial confirmed the high pathologic response rates that can be achieved by neoadjuvant IPI plus NIVO. Both trials show that pathologic response can function as a surrogate markers for RFS.Clinical trial informationNCT02437279, NCT02977052Disclosure InformationJ.M. Versluis: None. E.A. Rozeman: None. A.M. Menzies: F. Consultant/Advisory Board; Modest; BMS, MSD, Novartis, Roche, Pierre-Fabre. I.L.M. Reijers: None. O. Krijgsman: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; BMS. E.P. Hoefsmit: None. B.A. van de Wiel: None. K. Sikorska: None. C. Bierman: None. P. Dimitriadis: None. M. Gonzalez: None. A. Broeks: None. R.M. Kerkhoven: None. A.J. Spillane: None. J.B.A.G. Haanen: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; BMS, MSD, Neon Therapeutics, Novartis. F. Consultant/Advisory Board; Modest; BMS, MSD, Novartis, Pfizer, AZ/MedImmune, Rocher/Genentech, Ipsen, Bayer, Immunocore, SeattleGenetics, Neon Therapeutics, Celsius Therapeutics, Gadet, GSK. W.J. van Houdt: None. R.P.M. Saw: None. H. Eriksson: None. A.C.J. van Akkooi: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; Amgen, BMS, Novartis. F. Consultant/Advisory Board; Modest; Amgen, BMS, Novartis, MSD Merck, Merck-Pfizer, 4SC. R.A. Scolyer: F. Consultant/Advisory Board; Modest; MSD, Neracare, Myriad, Novartis. T.N. Schumacher: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; MSD, BMS, Merck. E. Ownership Interest (stock, stock options, patent or other intellectual property); Modest; AIMM Therapeutics, Allogene Therapeutics, Amgen, Merus, Neogene Therapeutics, Neon Therapeutics. F. Consultant/Advisory Board; Modest; Adaptive Biotechnologies, AIMM Therapeutics, Allogene Therapeutics, Amgen, Merus, Neon Therapeutics, Scenic Biotech. Other; Modest; Third Rock Ventures. G.V. Long: F. Consultant/Advisory Board; Modest; Aduro, Amgen, BMS, Mass-Array, Pierre-Fabre, Novartis, Merck MSD, Roche. C.U. Blank: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; BMS, Novartis, NanoString. E. Ownership Interest (stock, stock options, patent or other intellectual property); Modest; Uniti Cars, Neon Therapeutics, Forty Seven. F. Consultant/Advisory Board; Modest; BMS, MSD, Roche, Novartis, GSK, AZ, Pfizer, Lilly, GenMab, Pierre-Fabre.
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Liliána, Birtalan Ilona, Kis Bernadett, and Bárdos György. "A KÖZÖSSÉG ÁLTAL TÁMOGATOTT MEZŐGAZDÁLKODÁS SZUBJEKTÍV ASPEKTUSAI." Magyar Pszichológiai Szemle 75, no. 2 (November 10, 2020): 271–88. http://dx.doi.org/10.1556/0016.2020.00016.
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Elméleti háttérA közösség által támogatott mezőgazdálkodás (CSA) gyorsan növekvő jelenség világszerte, a helyi élelmiszer termelésének és elosztásának az a módja, amikor a termelő és a fogyasztók (tagok) közvetlenül elköteleződnek egymás felé. A közösségi mezőgazdálkodási rendszerek, mint alulról jövő társadalmi kezdeményezések, az élelmiszerek „árutlanítása" felé tett törekvésként is értelmezhetők, és szorosan kapcsolódnak a fenntarthatóság kérdésköréhez, mely a pszichológiai és az egészségfejlesztési diskurzusba hazánkban még alig került be.MódszertanA szakirodalmak kiválasztása során először konkrét szókombinációk mentén kerestünk cikkeket, majd a talált cikkek irodalmi hivatkozásait áttanulmányoztuk; illetve szakirodalom-kereső portálok elsődlegesen talált cikkeihez ajánlott további cikkeit tekintettük át a CSA-részvétellel járó tapasztalatok szempontjából.EredményekÁttekintésünk alapján látható, hogy a részvétel nemcsak konkrét előnyök mentén értelmezhető, hanem a további aspektusok, mint Hasonló gondolkodás, Lokalitás (város-vidék tengely), Személyes törődés, Életmódváltás, valamint az Újraírt sémák taglalása is legalább olyan fontos.KövetkeztetésekVéleményünk szerint a CSA-ban való részvétel átgondolása hasznos információkat nyújthat többek között a fenntartható pozitív mentális egészség fogalmának kibontásában.Theoretical backgroundCommunity Supported Agriculture (CSA) is a rapidly growing phenomenon worldwide, a model of production and distribution of local food that connects the producer and consumers (members) directly. As a grassroot initiative, CSAs can be seen as a step towards the decommodification of food and are directly associated with sustainability which is rarely involved in psychological and health promotional discourse in Hungary.MethodsIn the selection process of literature, at first papers containing specific word combinations were selected. Articles recommended by academic literature search portals during this process and references section of the selected papers were studied further in the context CSA involvement to find more relevant articles.ResultsBased on our review it seems that CSA participation can be interpreted not only through factual advantages: Similar Thinking, Locality: urban-rural axis, Personal Care, Lifestyle Change, and Rewriting of Schemes are at least as important.ConsequenciesAccording to our view, studying participation in CSA may yield useful information for developing the concept of sustainable positive mental health.
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Hamir, Amir N., and Charles E. Rupprecht. "Hepatic Capillariasis (Capillaria Hepatica) in Porcupines (Erethizon Dorsatum) in Pennsylvania." Journal of Veterinary Diagnostic Investigation 12, no. 5 (September 2000): 463–65. http://dx.doi.org/10.1177/104063870001200514.
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Tissues of 53 adult porcupines ( Erethizon dorsatum) from Pennsylvania were obtained for histopathologic examination. Hepatic capillariasis was recorded in 9% of the porcupines. An additional 11% of the liver sections showed lesions that were compatible with migration by Capillaria hepatica. Because only 1 section of the liver per animal was examined microscopically, the documented prevalence of C. hepatica in Pennsylvania is considered conservatively low. However, this condition was subclinical, because none of the infected animals showed clinical signs, and none revealed severe pathologic changes in the affected livers. This seems to be the only report of C. hepatica in porcupines.
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HASSAN, SAMIA, MISBAH KAUSAR JAVAID, and SADIA TARIQ. "EMERGENCY CAESAREAN SECTION." Professional Medical Journal 15, no. 02 (March 10, 2008): 211–15. http://dx.doi.org/10.29309/tpmj/2008.15.02.2772.
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Objective: Comparative analysis of problems encountered betweenpatients of elective caesarean section and patients for whom elective caesarean section was planned but ended upin emergency caesarean section. Design: Descriptive prospective analysis. Setting: Gynae Unit-II, Services Hospital,Lahore. Duration: One year, 1 January 2006 to 31 December 2006. Patients & Methods: A prospective study of st st100 patients who presented for antenatal care (ANC) and for whom elective caesarean section (CS) was planned wasdone. Patients evaluation was done on a designed performa that included demographic, social and obstetrical histories.Problems encountered in the preparatory stage, logistic problems, administrative problems, problems encounteredduring surgery, maternal, fetal mortality and morbidity were noted. Results: The patients were divided into twocategories. Categories I: included patients who had elective CS and category II: included patients who ended up inemergency CS. Numerous problems were encountered for category II patients. In the preparatory phase there wasdifficulty in arranging medicines for 32 patients. (59.2%), arranging blood for 28 patients (51.8%), obtaining consentfor 1 patient (1.85%). Logistic problems included non-availability of operation theatre for 15 patients (27.75%), nonavailability of anaesthetist for 9 patients (16.65%), and non-availability of paediatrician for 38 babies (17.3%). Noneof the emergency CS were done with in the recommended 30 minutes interval. Despite this, there was no significantcoloration between the decision delivery interval (DDI) and perinatal outcome. In our study like threatening cases wereoperative within 60 minutes. Intra operative problems in the category II patients included adhesions in 40 patients (74%)vs 10 patients (21.7%) of category I, partial dehiscence in 16 patients (29.6%) of category II vs 4 patients (8.68%) ofcategory I. Excessive hemorrhage in 8 patients (14.8%) of category II vs 2 patients (4.34%) of category I. Among thepost operative complications anemia was present in 20 patients (43.4%) of category I vs 45 patients (83.25%) ofcategory II patients. Blood transfusion was required for 16 patients (29.6%) of category II vs 4 patients (8.68%) ofcategory I and all patients were given iron supplement. Major wound infection were seen in 9 patients (16.65%) ofcategory II vs 2 patients (4.34%) of category I. Resuturing was done after appropriate antibiotic cover and dailyantiseptic dressing. Minor wound infections were seen in 22 patients (40.7%) of category II vs 12 patients (26.04%)of category I. Urinary Tract Infections (UTI) was seen in 6 patients (11.1%) of category II vs 1 patient (2.17%) ofcategory I. Respiratory Tract Infection (RTI) was seen in 5 patients (9.25%) of category II vs 2 patients (4.34%) ofcategory I. All these were treated by appropriate antibiotic cover. Regarding the neonatal outcome 16 babies (29.6%)of category II were kept under observation in neonatal nursery (NNU) as compared to 6 (13.02%) babies of categoryI. Admission for 2-10 days in NNU were 8 babies (14.96%) of category II vs 2 babies (4.34%) of category I. 2 babies(3.74%) of category II expired later while none of category I. Conclusion: Patients for whom elective CS was plannedbut who ended up in emergency CS, the DDI was prolonged and there was increase risk of maternal morbidity, fetalmorbidity and mortality as compared to those patients who had elective CS.
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Holbrook, C. Corley, David M. Wilson, Michael E. Matheron, and William F. Anderson. "Aspergillus Colonization and Aflatoxin Contamination in Peanut Genotypes with Resistance to Other Fungal Pathogens." Plant Disease 81, no. 12 (December 1997): 1429–31. http://dx.doi.org/10.1094/pdis.1997.81.12.1429.
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Indirect selection tools would be valuable in the development of peanut (Arachis hypogaea) cultivars with resistance to aflatoxin contamination. The objective of this study was to determine whether resistance to other fungi could be used as an indirect selection tool for resistance to colonization of peanut by Aspergillus flavus group fungi or aflatoxin contamination. Nine peanut genotypes with resistance to late leaf spot (Cercosporidium personatum) or white mold (Sclerotium rolfsii) were evaluated for 2 years at Tifton, GA, and Yuma, AZ. Plots were subjected to late-season heat and drought stress. None of the genotypes exhibited less colonization of shells or kernels by A. flavus group fungi than cv. Florunner when tested in Georgia or Arizona. None of the genotypes showed a reduced level of aflatoxin contamination in comparison to Florunner at either location. These results indicate that the mechanisms of resistance to other fungi operating in these genotypes are not effective in providing resistance to colonization by A. flavus group fungi or reducing aflatoxin contamination. Therefore, resistance to these fungi cannot be used as an indirect selection tool for resistance to aflatoxin contamination.
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Zemzoum, Iris, Ronald E. Kates, Jeffrey S. Ross, Peer Dettmar, Moshumi Dutta, Cordula Henrichs, Suna Yurdseven, et al. "Invasion Factors uPA/PAI-1 and HER2 Status Provide Independent and Complementary Information on Patient Outcome in Node-Negative Breast Cancer." Journal of Clinical Oncology 21, no. 6 (March 15, 2003): 1022–28. http://dx.doi.org/10.1200/jco.2003.04.170.
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Purpose: The independent clinical relevance of invasion factors urokinase-type plasminogen activator (uPA)/PAI-1 and HER2 status was evaluated in lymph node-negative breast cancer patients (N = 118) without adjuvant systemic therapy after long-term follow-up of more than 10 years (median, 126 months). Patients and Methods: Levels of uPA and its inhibitor PAI-1 were prospectively measured by enzyme-linked immunosorbent assay in primary tumor tissue extracts. HER2 gene amplification (HER2_AMP) was evaluated by fluorescence in situ hybridization (FISH; Ventana Medical Systems HER-2/neu probe; Tucson, AZ), and HER2 protein overexpression (HER2_EXP) was evaluated by immunohistochemistry (IHC; Oncogene Science antibody Ab-3; Cambridge, MA) on parallel-cut formalin-fixed paraffin-embedded tissue sections. Results: uPA/PAI-1 was high (either one or both factors were high) in 44% of the tumors. HER2_AMP was detected by FISH in 33% of the patients, and HER2_EXP was found by IHC in 44% of the patients. In a multivariate analysis of established and tumor-biologic prognostic factors, uPA/PAI-1 was the only independent prognostic factor for disease-free survival ([DFS]; P < .001; relative risk [RR], 8.3; 95% confidence interval [CI], 3.4 to 20.4). Although HER2_AMP and HER2_EXP did not reach significance for DFS, they were significant for overall survival (OS), even in multivariate analysis (HER2_AMP: P = .004; RR, 3.7; 95% CI, 1.5 to 9.2; HER2_EXP: P = .009; RR, 3.4; 95% CI, 1.4 to 8.7). Conclusion: After long-term follow-up, uPA/PAI-1 levels in primary tumor tissue reliably and strongly indicate an aggressive course of disease in lymph node-negative breast cancer independent of HER2 status. The particular prognostic effect of HER2 status on OS may reflect its ability to predict resistance to systemic therapy.
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Kakkar, Rakesh, and Pradeep Aggarwal. "Book Review: ‘Till We Win - India’s fight against the COVID-19 Pandemic’." Indian Journal of Community Health 32, no. 4 (December 31, 2020): 755–56. http://dx.doi.org/10.47203/ijch.2020.v32i04.028.
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‘Till We Win’ is a book which provides a comprehensive overview of India’s journey. It deliberates how India, as a nation, fought and continue to fight against the novel coronavirus, SARS CoV-2. It documents and analyses the COVID-19 pandemic responses and provides lessons for health systems strengthening.
The book has four section and eleven chapters. The first section focuses upon why viruses are likely to cause pandemic and how human activities are increasing the risks of outbreaks and epidemics. The next section deliberates on India’s pandemic response and how the policies had evolved with every new emerging condition. The authors argue that none of the country was fully prepared for the pandemic of the such a magnitude which eventually had disrupted even ‘so called’ better performing health system.
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Park, Min Soo, Hyung Gyun Park, Jun Ho Choi, and Kwon Hoo Kim. "Effect of Aluminum Content on Texture Formation Behaviors in Magnesium Alloy." Materials Science Forum 879 (November 2016): 1449–53. http://dx.doi.org/10.4028/www.scientific.net/msf.879.1449.
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In order to understand the effects of the solute element and its concentration on the formation of texture, uniaxial compression tests were carried out at various deformation conditions with different aluminum solute concentration in rolled AZ magnesium alloy (AZ31, AZ61, AZ91). To clarify the texture measurements and crystal orientation distribution, X-ray diffraction methods were conducted on mid plane section of the specimens. As a result in this study, the formation of fiber texture and occurrence of dynamic recrystallization were observed in all case of specimens. The main components and its sharpness of texture were varied depending on deformation conditions and Al concentrations. Especially, accumulation of basal texture was developed with an increasing of Al concentration.
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Mariak, Zenon, Jaroslaw Krejza, Miroslaw Swiercz, Kazimierz Kordecki, and Janusz Lewko. "Accuracy of transcranial color Doppler ultrasonography in the diagnosis of middle cerebral artery spasm determined by receiver operating characteristic analysis." Journal of Neurosurgery 96, no. 2 (February 2002): 323–30. http://dx.doi.org/10.3171/jns.2002.96.2.0323.
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Object. The value of transcranial Doppler ultrasonography for the detection of middle cerebral artery (MCA) spasm has been asserted. None of the published studies, however, has adequately scrutinized the overall diagnostic accuracy of this procedure. There are only sporadic reports concerning the utility of transcranial color Doppler (TCCD) ultrasonography, although this method has been proved to be more precise. In this study the authors attempted to estimate the performance of TCCD ultrasonography in detecting MCA narrowing by using receiver operating characteristic (ROC) curve analysis, based on TCCD studies obtained in a relatively large, randomly selected population of patients. Methods. Transcranial color Doppler ultrasonography studies were obtained in 100 consecutive patients (54 men and 46 women ages 18–74 years, median age 50 years) routinely referred by neurosurgeons for intraarterial angiography. The M1 segment of the MCA was insonated using a 2.5-MHz probe via a temporal acoustic window, and angle-corrected flow velocities were obtained. Angiographically depicted vasospasm was graded as none, mild (≤ 25% vessel caliber reduction), and moderate to severe (> 25% vessel caliber reduction). The effectiveness of TCCD ultrasonography in diagnosing MCA spasm was evaluated by calculating the areas under the ROC curves (Az). Of the 200 MCAs examined, 173 were successfully visualized with the aid of TCCD ultrasonography. Mild vasospasm was angiographically diagnosed in 15 arteries and moderate-to-severe vasospasm in 28. The best-performing TCCD parameter for the detection of MCA narrowing was revealed to be peak systolic velocity. The Az value for moderate-to-severe vasospasm only was 0.93 and that for all vasospasms was 0.8. The best efficiency, that is, the optimal tradeoff between sensitivity and specificity in diagnosing vasospasms, was associated with a peak systolic velocity of 182 cm/second. Conclusions. The performance of TCCD ultrasonography in the diagnosis of advanced MCA narrowing is very good, and is acceptable for all vasospasms. The best-performing parameter was peak systolic velocity.
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Burnside, Craig. "The Cross Section of Foreign Currency Risk Premia and Consumption Growth Risk: Comment." American Economic Review 101, no. 7 (December 1, 2011): 3456–76. http://dx.doi.org/10.1257/aer.101.7.3456.
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Lustig and Verdelhan (2007) argue that the excess returns to borrowing US dollars and lending in foreign currency “compensate US investors for taking on more US consumption growth risk,” yet the stochastic discount factor corresponding to their benchmark model is approximately uncorrelated with the returns they study. Hence, one cannot reject the null hypothesis that their model explains none of the cross sectional variation of the expected returns. Given this finding, and other evidence, I argue that the forward premium puzzle remains a puzzle. JEL: C58, E21, F31, G11, G12
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Hall, A. D., B. K. Puri, T. Stewart, and P. S. Grahame. "Doctors' Holding Power in Practice: Section 5(2) of the Mental Health Act 1983." Medicine, Science and the Law 35, no. 3 (July 1995): 231–36. http://dx.doi.org/10.1177/002580249503500310.
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Section 5(2) of the Mental Health Act 1983 (England and Wales) is a commonly used short term power of detention often implemented by junior medical staff, which has no statutory right of appeal. There is little published analysis of its use in clinical practice. A detailed case note study of its use in a psychiatric service with a large catchment area is presented. Fifty-seven per cent of the patients detained under s.5(2) were female. Affective psychosis was over-represented in detained females, while schizophrenia and paranoid states were over-represented in males. Eight per cent of s.5(2) detentions were initiated via the nurses' holding power, s.5(4). None of these patients were subsequently regraded to s.2 or 3, which may be accounted for by the finding that personality disorder and alcohol dependence were more commonly diagnosed in this subgroup. Of s.5(2) detainees, none of those with a non-psychotic disorder were regraded to s.2 or 3. Three patients had not accepted in-patient admission prior to implementation of s.5(2). Moreover, 38 per cent of all s.5(2) detentions took place within 24 hours of admission. Patients with a psychotic disorder were more likely to be detained within 24 hours of admission. Doubts regarding the validity of consent to voluntary admission in these patients are raised.
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Viczei, Alexandra, István Lapis, Ádám Marián Brzózka, and György Szeifert. "Arteria vertebralis thrombosis egy 7 éves gyermekben." Orvosi Hetilap 162, no. 47 (November 21, 2021): 1902–7. http://dx.doi.org/10.1556/650.2021.32281.
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Összefoglaló. Az agyi érrendszer elzáródásos panaszai elsősorban felnőttkorban jelentkeznek, nem ritkák azonban gyermekek esetében sem. A gyermekkori stroke gyakorisága 2,5/1 000 000 fő; ilyenkor általában az arteria carotis interna vagy az arteria cerebri media érintett. Az ischaemiás stroke-ok 25%-a a hátsó keringési rendszer területén keletkezik. Az arteria vertebralis extracranialis szakaszának stenosisa 18%-ban a jobb oldalon, 22,3%-ban a bal oldalon észlelhető. Esetünkben egy 7 éves kisfiú kórtörténetét mutatjuk be, aki facialis paresis, súlyosbodó ataxia és somnolentia tüneteivel került egy megyei kórház gyermek intenzív osztályára. A készült kontrasztos koponya angiográfiás MR-vizsgálaton akut ischaemiás elváltozások voltak láthatók, valamint sejteni lehetett, hogy a bal oldali arteria vertebralis gracilisabb; a hypoplasia azonban csak a beteg egyetemi centrumba kerülése után, az ott elvégzett, a nyaki erekre is kiterjedő TOF - (time of flight) angiográfia és nyaki ultrahang készítését követően bizonyosodott be. A beállított gyógyszeres kezelések hatására az ischaemiát okozó artériás thrombus feloldódott, majd megkezdődött a rehabilitáció folyamata, melynek során a beteg állapota nagymértékben javult. A gyermek kórházba kerülése előtt hónapokkal észlelt, magatartás- és figyelembeli zavarainak romlása felveti a már korábban bekövetkező átmeneti ischaemiás periódusok lehetőségét is. A hátsó keringési rendszert érintő stroke-ok etiológiája változó, többször kerültek már leírásra különböző háttérrel. Esetünkben a fejlődési rendellenesség – ’bow hunter’ szindróma tűnik a legvalószínűbbnek. A készült dinamikus nyaki ultrahangvizsgálat is erre utaló eredményt adott. Időintervallumon belül szóba jöhet az arteria vertebralis thrombosis kezelése endovascularis módszerek segítségével is. Ennek kivitelezhetősége érdekében azonban fontos a mielőbbi pontos diagnózis felállítása a megfelelő képalkotó vizsgálatok segítségével és a betegnek a kezelésére felkészült centrumba juttatása. Orv Hetil. 2021; 162(47): 1902–1907. Summary. Cerebrovascular obstruction primarily affects adults, but it is not uncommon in children either. The incidence of childhood stroke is 2.5/1 000 000 population, usually affecting the internal carotid artery or the middle cerebral artery. The posterior circulatory system is involved in 25% of ischemic strokes. Stenosis of the extracranial section of the vertebral artery is demonstrated in 18% on the right side and 22.3% on the left side. We present the case history of a 7-year-old boy who was admitted to the pediatric intensive care unit of a county hospital with symptoms of facial palsy, progrediating ataxia and somnolence. Contrast-enhanced angiographic MR images of the skull revealed acute ischemic lesions and suggested stenosis of the left vertebral artery, then it was confirmed by TOF (time of flight) angiography of vessels of the neck and cervical ultrasound examination. The arterial thrombus causing ischaemia was eliminated by drug treatment and the rehabilitation process could be started. The patient’s condition improved considerably following that. Deterioration in behavioral and attentional problems of the patient, which had been realised months prior to hospitalisation, raises the possibility of earlier ischemic periods. The etiology of strokes affecting the posterior circulatory system has been described with different backgrounds. In the presented case, a developmental disorder – bow hunter’s syndrome seems to be the most likely one. The result of dynamic cervical ultrasound examination also supported this theory. Treatment of vertebral artery thrombosis with endovascular methods may also be considered within a time interval. However, to make it feasible, it is important to establish an accurate diagnosis as soon as possible by appropriate imaging studies, and to transfer the patient to a specialised center. Orv Hetil. 2021; 162(47): 1902–1907.
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Abboud, Therese K., Michael J. Moore, Jerry Jacobs, Kazushige Murakawa, Manoutchehr Soraya, and Jay Zhu. "Epidural Mepivacaine for Cesarean Section: Maternal and Neonatal Effects." Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control 12, no. 2 (April 1987): 76–79. http://dx.doi.org/10.1136/rapm-00115550-198712020-00003.
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The effects of epidural anesthesia using mepivacaine on maternal blood pressure, newborn Apgar scores, neonatal acid-base status, and the Early Neonatal Neurobehavioral Scale (ENNS) were studied in 21 pregnant women undergoing cesarean section. Maternal and neonatal blood levels of mepivacaine were also determined. Neonatal outcome was compared with a control group of 14 neonates of healthy mothers who received 3% 2-chloroprocaine for elective cesarean section. All patients had satisfactory anesthesia for cesarean section with an onset of 19 ± 1.8 minutes (mean ± SEM) and duration of 95 ± 11.9 minutes. Hypotension developed in two patients, and they were treated with intravenous ephedrine. All neonates had Apgar scores of 8 or more at 1 and 5 minutes and normal blood gases and acid-base status. None of the variables of the ENNS differed significantly between the mepivacaine and the chloroprocaine control group with the exception of truncal tone, which was significantly higher in the mepivacaine group ( p < 0.05). Mepivacaine was detected in all maternal and fetal samples, and the umbilical venous to maternal venous ratio was 0.57 ± 0.17 (mean ± SEM).
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Lowe-Ponsford, Francesca L., and Ayaz Begg. "Place of Safety and Section 136 at Gatwick Airport." Medicine, Science and the Law 36, no. 4 (October 1996): 306–12. http://dx.doi.org/10.1177/002580249603600406.
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Seventy-nine adults and nineteen children were arrested at Gatwick Airport under s.136 over the period of one year although not all were formally held under this section at the police station (i.e. not all were accepted by the custody police officer). Their notes at the police station were reviewed. None of the children and only half of the adults were eventually seen by a doctor. The police were able to deal with the others. Half of these latter were missing persons. Those referred to a doctor tended to be suicidal or confused compared with those who were dealt with solely by the police. In addition, the police station as a place of safety probably influenced management in that people were dealt with quickly. The phenomenon of ‘wanderers’ is commented upon. This study suggests that when reviewing people held by the police as a result of their behaviour, a more comprehensive study can be performed by considering those arrested under s.136, but needing a more informal approach, at the police station.
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Gupta, Nupur, Taru Gupta, and Ritu Singh. "Feto-maternal outcome in second versus first stage caesarean delivery in a tertiary medical care centre." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 12 (November 26, 2018): 5084. http://dx.doi.org/10.18203/2320-1770.ijrcog20184971.
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Background: The aim is to study neonatal and maternal outcomes of the caesarean sections performed in first stage versus second stage of labour. Methods: The retrospective analysis of data were done of caesarean section done at Department of Obstetrics and Gynaecology at ESI PGIMSR Basaidarapur New Delhi between January 2016 to December 2016. 45 women, who underwent second stage caesarean section were studied. For each case, two consecutive cases, who underwent caesarean delivery during the first stage of labour were taken as control for the study. Primary maternal outcomes of interest were uterine atonia, transfusion requirement, urinary system injury and postoperative complications. Results: Out of 4477 deliveries, 1466 had caesarean section with a rate of 32%. The rate of second stage caesarean section was 3% of total caesarean section and 1% of total deliveries. Second stage caesarean section had higher maternal and perinatal morbidity like atonic PPH (33.3%), lower uterine segment extension (7%), febrile morbidity (10%), and need for blood transfusion (15%). There were 15.5% NICU admission in second stage caesarean group while none in first stage group. Conclusions: Caesarean section in the second stage of the labour is associated with increased maternal and neonatal morbidities. Special attention is required to the patients undergoing caesarean section in the second stage of the labour. They should be handled by senior and experienced obstetrician. Neonatologist should be present for every second stage caesarean section.
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Vaswani, Babita P., Aditi Trivedi, and Sriram Gopal. "Extraperitoneal versus transperitoneal cesarean section: a retrospective analysis." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 2 (January 28, 2020): 567. http://dx.doi.org/10.18203/2320-1770.ijrcog20200337.
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Background: Cesarean section is becoming a more common delivery type worldwide. The objective of this study was to compare surgical morbidity in extraperitoneal versus transperitoneal techniques of cesarean section.Methods: A total of 60 patients was included in this study out of which 30 underwent extraperitoneal cesarean section(ECS) and 30 patients underwent transperitoneal cesarean section (TCS) and compared both the techniques with respect to nausea or vomiting intra-operatively, pain score (as measured by visual analogue scale) post operatively, return of bowel function and blood loss.Results: Intra-operative nausea and vomiting was noted in 33.34% of patients in TCS group while none of the patients in ECS group had any such complaints. No difference was noted in average blood loss between the 2 groups. Post-operative pain in ECS was 4.13 as compared to 6.86 in TCS. Return of bowel sounds in ECS group was much earlier (5.46 hours) as compared to TCS group (11.33 hours).Conclusions: We conclude that extraperitoneal technique is advantageous over transperitoneal approach. Decreased nausea and vomiting, early return of bowel function in the post-operative period, decreased post-operative pain allowing early feeding and mobilization are definite benefits of this technique. This further helps in making a relatively smoother post-operative recovery.
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Fehér, Ágnes, Ildikó Istenes, Júlia Weisinger, Péter Király, Anna Rakonczai, Ilona Tárkányi, Ágnes Kárpáti, et al. "Akut coronaria szindrómán átesett thrombocytopeniás betegek thrombocytaaggregáció-gátló gyógyszeres kezelése." Orvosi Hetilap 162, no. 33 (August 15, 2021): 1335–40. http://dx.doi.org/10.1556/650.2021.32149.
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Összefoglaló. Az akut coronaria szindrómán (ACS) átesett betegek kezelésének alappillére a kettős (aszpirin + klopidogrél ) thrombocytaaggregáció-gátló kezelés. Az immunthrombocytopeniás purpurás (ITP-s) betegek – és különösen azok, akik refrakter ITP miatt thrombopoetinanalóg kezelésben részesülnek – külön elbírálást igényelnek. 50–100 G/l thrombocytaszám közötti és vérzéses szövődménnyel nem rendelkező ACS-s betegeken a gyógyszerkibocsátó stent beültetését követően kettős thrombocytaaggregáció-gátló kezelést csak 1 hónapig kell alkalmazni (ez az időtartam átlagos vérzéses rizikójú betegeken 1 év), majd klopidogrél-monoterápia javasolt. Munkánk során a 2015. január 1. és 2020. október 1. között a Semmelweis Egyetem I. Belgyógyászati Klinikáján kezelt ITP-s betegek körében vizsgáltuk az ACS előfordulását és lefolyását. Klinikánkon az elmúlt 5 évben gondozott, 168 ITP-s beteg közül 3 beteg esetében alakult ki ACS. A refrakter ITP kezelésének részeként mind a 3 beteg thrombopoetinanalóg - (2 beteg romiplosztim-, 1 beteg eltrombopág-) kezelésben részesült. A 3 ITP-s betegünk egyikénél sem alakult ki vérzéses szövődmény a thrombopoetinanalóg-kezelés és a thrombocytaaggregáció-gátlás mellett. Első betegünk esetében 5 év alatt három alkalommal alakult ki ACS (egy ízben fémstentet és két alkalommal gyógyszerkibocsátó stentet kapott). A második betegnél két alkalommal (1 év különbséggel), a harmadik betegnél egy esetben történt gyógyszerkibocsátó stent beültetése. ITP és ACS együttes fennállása esetén az akut és a hosszú távú gyógyszeres kezelés egyéni mérlegelést igényel. Ezen speciális betegcsoport számára a kezelési irányelv kidolgozása megfontolandó. Orv Hetil. 2021; 162(33): 1335–1340. Summary. Dual antiplatelet therapy (DAPT) consisting of aspirin and clopidogrel is essential in the treatment of acute coronary syndrome (ACS). Immune thrombocytopenic purpura (ITP) patients – and especially those receiving thrombopoietin analog (TPO) treatment – deserve special attention. In ACS patients with platelet counts between 50 G/L and 100 G/L and no bleeding symptoms, DAPT is indicated for 1 month after the placement of new generation drug-eluting stents (the length of treatment is 1 year in the case of patients with average bleeding risk) followed by clopidogrel monotherapy. In patients with average bleeding risk, DAPT is recommended for 1 year after the ACS. Our aim was to investigate the incidence and outcome of ACS in ITP patients, who were treated in our clinic between 1st January 2015 and 1st October 2020. Out of 168 patients treated for ITP, 3 patients suffered from ACS in the last 5 years. These patients received TPO treatment (2 patients subcutan romiplostim, 1 patient oral eltrombopag). None of these ITP patients treated with DAPT and with TPO analog suffered from bleeding complications. 1 patient developed ACS three times within the last 5 years (he received bare-metal stent once and drug-eluting stent twice). Drug-eluting stent was placed once in the third, and twice (with 1 year difference) in the second patient. Acute and long-term medication of patients suffering from both ITP and ACS is a challenging task and needs individual evaluation. Establishment of treatment guidelines for this special group is warranted. Orv Hetil. 2021; 162(33): 1335–1340.
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Horváth, Örs Péter, András Papp, András Vereczkei, and Gábor Pavlovics. "Nyelőcsőpótlás hybrid, supercharged jejunummal." Magyar Sebészet (Hungarian Journal of Surgery) 74, no. 4 (November 25, 2021): 110–13. http://dx.doi.org/10.1556/1046.74.2021.4.1.
Full textAbstract:
Összefoglaló. Bevezetés: Esetünkben nyelőcsőtumor miatt történt nyelőcső reszekció és bal colonféllel pótlás egy korábban gyomor reszekált betegen. A graftelhalás miatt a nekrotizált vastagbélszakaszt eltávolítottuk. Az egy év múlva végzett rekonstrukciónál kombinált vérellátású jejunummal való pótlást alkalmaztunk. A három egyenes ág lekötése után a Roux kacs nem volt elég hosszú, ezért a 2. és 3. egyenes ág között az árkádot átvágva már biztonságosan felért a nyakra. A 3. ág által ellátott terület vérellátását a mammaria interna arteriájából biztosítottuk és a vénás elvezetést egy vena saphena szegmenttel biztosítottuk a vena jugularis externa felé. A jejunum graft folytonossága megmaradt. A beteg meggyógyult. Ha a nyelőcsőpótlásra rutinszerűen használt gyomor és vastagbél anatómiai okok, előző műtétek vagy szövődmények miatt alkalmatlanok, akkor az egyik utolsó lehetőség a jejunummal való pótlás. A jejunum csak szabad átültetéssel vagy a keringés megerősítésével (supercharging) alkalmas az oesophagectomia utáni biztonságos pótlásra. A kombinált vérellátású jejunum pótlást hybrid, supercharged módszernek neveztük el. Summary. Introduction: In this case report an esophageal resection due to cancer was performed with a primary left colonic replacement, as the stomach was resected previously. Due to graft necrosis, the necrotized section of the colon was removed. One year later a long jejunal segment with a combined blood supply was used for secondary reconstruction. Even after the ligation of three straight branches, the Roux loop was not long enough to reach up to the neck, however the division of the arcade between the 2nd and 3rd straight branches lengthened it satisfyingly. Blood supply to the region of the farthest branch was provided from the internal mammary artery and venous drainage was provided by a saphenous vein graft to the external jugular vein. The continuity of the jejunal graft was preserved. The patient recovered uneventfully. If neither the stomach nor the colon routinely used for esophageal replacement are available due to anatomical reasons, previous surgeries, or complications, jejunal replacement can be the last resort. Jejunum is only suitable for safe esophageal replacement by either free transplantation or by supercharging. The procedure when a combined blood supply is provided for the jejunal replacement was named the hybrid-supercharged method.