Academic literature on the topic 'Autophagy dysfunction'
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Journal articles on the topic "Autophagy dysfunction"
Lee, Jisun, Samantha Giordano, and Jianhua Zhang. "Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling." Biochemical Journal 441, no. 2 (December 21, 2011): 523–40. http://dx.doi.org/10.1042/bj20111451.
Full textSpaulding, HR, C. Ballmann, JC Quindry, MB Hudson, and JT Selsby. "Autophagy in the heart is enhanced and independent of disease progression in mus musculus dystrophinopathy models." JRSM Cardiovascular Disease 8 (January 2019): 204800401987958. http://dx.doi.org/10.1177/2048004019879581.
Full textMiceli, Caterina, Yohan Santin, Nicola Manzella, Raffaele Coppini, Andrea Berti, Massimo Stefani, Angelo Parini, Jeanne Mialet-Perez, and Chiara Nediani. "Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/8067592.
Full textDong, Qianqian, Wenjuan Xing, Feifei Su, Xiangyan Liang, Fei Tian, Feng Gao, Siwang Wang, and Haifeng Zhang. "Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy." Cellular Physiology and Biochemistry 43, no. 1 (2017): 293–307. http://dx.doi.org/10.1159/000480410.
Full textChen, Yan, Chengxing Xia, Chunwei Ye, Feineng Liu, Yitian Ou, Ruping Yan, Haifeng Wang, and Delin Yang. "MT-12 inhibits the proliferation of bladder cells in vitro and in vivo by enhancing autophagy through mitochondrial dysfunction." Open Life Sciences 17, no. 1 (January 1, 2022): 710–25. http://dx.doi.org/10.1515/biol-2022-0082.
Full textGukovskaya, Anna S., and Ilya Gukovsky. "Autophagy and pancreatitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 9 (November 1, 2012): G993—G1003. http://dx.doi.org/10.1152/ajpgi.00122.2012.
Full textKang, Liang, Qian Xiang, Shengfeng Zhan, Yu Song, Kun Wang, Kangcheng Zhao, Shuai Li, Zengwu Shao, Cao Yang, and Yukun Zhang. "Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration." Oxidative Medicine and Cellular Longevity 2019 (December 30, 2019): 1–27. http://dx.doi.org/10.1155/2019/7810320.
Full textKo, Su-Hyuk, Gilberto Gonzalez, Zhijie Liu, and Lizhen Chen. "Axon Injury-Induced Autophagy Activation Is Impaired in a C. elegans Model of Tauopathy." International Journal of Molecular Sciences 21, no. 22 (November 13, 2020): 8559. http://dx.doi.org/10.3390/ijms21228559.
Full textAzuelos, Ilan, Boris Jung, Martin Picard, Feng Liang, Tong Li, Christian Lemaire, Christian Giordano, Sabah Hussain, and Basil J. Petrof. "Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction." Anesthesiology 122, no. 6 (June 1, 2015): 1349–61. http://dx.doi.org/10.1097/aln.0000000000000656.
Full textLuo, Li, Yonghong Liang, Yuanyuan Fu, Zhiyuan Liang, Jinfen Zheng, Jie Lan, Feihai Shen, and Zhiying Huang. "Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction." Pharmaceuticals 15, no. 12 (December 3, 2022): 1509. http://dx.doi.org/10.3390/ph15121509.
Full textDissertations / Theses on the topic "Autophagy dysfunction"
Otten, Elsje Gesina. "Molecular mechanisms of autophagy and the effect of autophagy dysfunction on mitochondrial function." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3953.
Full textSimcox, Eve Michelle. "Degradation and degeneration : synergistic impact of autophagy and mitochondrial dysfunction in Parkinson's disease." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2430.
Full textHansson, Eva-Maria. "Towards a mechanistic explanation of insulin resistance, which incorporates mTOR, autophagy, and mitochondrial dysfunction." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54489.
Full textMorgan-Bathke, Maria Elizabeth. "The Role of Autophagy in Salivary Gland Dysfunction Following Targeted Head and Neck Radiation." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301532.
Full textWorkinger, Paul M., and Paul M. Workinger. "Familial Amyotrophic Lateral Sclerosis with a focus on C9orf72 Hexanucleotide GGGGCC Repeat Expansion Associated ALS with Frontotemporal Dementia." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625350.
Full textFONTANA, FABRIZIO. "APOPTOSIS AND PARAPTOSIS, INVOLVING ENDOPLASMIC RETICULUM STRESS, AUTOPHAGY AND MITOCHONDRIAL DYSFUNCTION, ARE INDUCED BY DELTA-TOCOTRIENOL IN PROSTATE CANCER CELLS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/699447.
Full textKeane, Harriet. "Network pharmacology of the MPP+ cellular model of Parkinson's disease." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:1e18e521-c1a3-4f1b-9572-9c68e0f16c2f.
Full textOrr, Miranda, and Salvatore Oddo. "Autophagic/lysosomal dysfunction in Alzheimer's disease." BioMed Central, 2013. http://hdl.handle.net/10150/610220.
Full textGonçalves, Ana Catarina Martins. "Relação entre a infeção por Escherichia coli aderente-invasina e a doença de Crohn." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4089.
Full textA Doença de Crohn é uma doença inflamatória crónica que pode afetar qualquer parte do trato gastrointestinal, embora comprometa preferencialmente o íleo. Apesar da incessante investigação a sua etiologia e patogénese permanecem desconhecidas. Até ao momento várias hipóteses têm sido avançadas na compreensão desta doença. Contudo, a teoria atual considera que se trata de uma doença complexa multifatorial que ocorre em indivíduos com predisposição genética, e que determinados fatores ambientais e microbianos são responsáveis pelo desenvolvimento de uma resposta inume inadequada. O possível envolvimento de um organismo infecioso, em particular a Escherichia coli Aderente-Invasiva (AIEC), tem estado sob investigação. A análise da flora bacteriana associada à mucosa ileal revelou uma anormal colonização da AIEC nos pacientes com Doença de Crohn. Estas bactérias são capazes de aderir e invadir as células epiteliais intestinais, assim como, penetrar e replicar extensivamente no interior dos macrófagos, sem induzir a morte da célula hospedeira. Por outro lado, a permeabilidade intestinal está significativamente aumentada nos indivíduos com Doença de Crohn. A AIEC diminui a resistência elétrica transepitelial e altera a estrutura morfológica das junções celulares, o que pode contribuir para esse aumento de permeabilidade. Pensa-se que as células M poderão constituir um potencial alvo de entrada que permite a interação bacteriana com os macrófagos da lâmina própria. Estudos in vitro têm demonstrado que os macrófagos infetados produzem grandes quantidades de fator de necrose tumoral α, e induzem a formação de agregados de células muitos semelhantes aos granulomas epitelioides. Estas estruturas representam uma das marcas histológicas características da Doença de Crohn. Crohn's disease is a chronic inflammatory disease that can affect any part of the gastrointestinal tract, although preferably compromise the ileum. Despite ongoing research its etiology and pathogenesis remain unknown. So far several hypotheses have been advanced in the understanding of this disease. However, the current theory considers that it is a complex multifactorial disease that occurs in individuals with a genetic predisposition and certain environmental and microbial factors are responsible for developing a response immune inadequate. The possible involvement of an infectious organism, in particular adherent-invasive Escherichia coli (AIEC) has been under investigation. The analysis of the bacterial flora associated with ileal mucosa revealed an abnormal AIEC colonization in patients with Crohn's disease. These bacteria are able to adhere to and invade intestinal epithelial cells, as well as penetrate and replicate extensively within macrophages without inducing the death of the host cell. On the other hand, is significantly increased intestinal permeability in patients with Crohn's disease. The AIEC decreases the transepithelial electrical resistance changes and the morphological structure of cell junctions, which may contribute to this increased permeability. It is believed that M cells might constitute a potential target input which allows the bacterial interaction with macrophages in the lamina propria. In vitro studies have demonstrated that infected macrophages produce large quantities of tumor necrosis factor α, and induce the formation of cell aggregates similar to many epithelioid granulomas. These structures represent one of the marks histological features of Crohn's disease.
MICELI, CATERINA. "Oleuropein aglycone induces protective autophagy: molecular mechanisms and therapeutic targets in pathological models of autophagy dysfunction." Doctoral thesis, 2017. http://hdl.handle.net/2158/1076892.
Full textBooks on the topic "Autophagy dysfunction"
Autophagy Dysfunction in Alzheimer's Disease and Dementia. Elsevier, 2022. http://dx.doi.org/10.1016/c2020-0-02800-8.
Full textHamano, Tadanori, and Tatsuro Mutoh. Autophagy Dysfunction in Alzheimer's Disease and Dementia. Elsevier Science & Technology Books, 2022.
Find full textHamano, Tadanori, and Tatsuro Mutoh. Autophagy Dysfunction in Alzheimer's Disease and Dementia. Elsevier Science & Technology, 2022.
Find full textNakamura, Tomohiro, and Stuart A. Lipton. Neurodegenerative Diseases as Protein Misfolding Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0002.
Full textBook chapters on the topic "Autophagy dysfunction"
Tao, Tao, and Huanbai Xu. "Autophagy and Obesity-Related Reproductive Dysfunction." In Autophagy: Biology and Diseases, 463–66. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4272-5_33.
Full textOtten, Elsje G., Diego Manni, and Viktor I. Korolchuk. "Mitochondrial Degradation, Autophagy and Neurodegenerative Disease." In Mitochondrial Dysfunction in Neurodegenerative Disorders, 255–78. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28637-2_11.
Full textGustafsson, Åsa B. "Mitochondrial Dysfunction and Mitophagy: Physiological Implications in Cardiovascular Health." In Biochemistry of Apoptosis and Autophagy, 197–217. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78799-8_11.
Full textZhang, Jianhua, and Victor Darley-Usmar. "Mitochondrial Dysfunction in Neurodegenerative Disease: Protein Aggregation, Autophagy, and Oxidative Stress." In Mitochondrial Dysfunction in Neurodegenerative Disorders, 95–111. London: Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-701-3_6.
Full textChatterjee, Sharmistha, Uday Hossain, and Parames C. Sil. "Role of Oxidative Stress, Mitochondrial Dysfunction, and Autophagy in Cardiovascular Disease: Its Pathogenesis and Amelioration by Different Small Natural Molecules." In Modulation of Oxidative Stress in Heart Disease, 457–87. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8946-7_19.
Full textKaira, Meenakshi, Abhilasha Ahlawat, Vaibhav Walia, and Munish Garg. "Autophagic Dysfunction in Neurodegeneration." In Quality Control of Cellular Protein in Neurodegenerative Disorders, 25–62. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1317-0.ch002.
Full textWu, Lin, Yingmei Zhang, and Jun Ren. "Aging, mitochondria, and autophagy." In Mitochondrial Dysfunction and Nanotherapeutics, 221–36. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-323-85666-9.00005-x.
Full textGupta, Rohan, Rashmi K. Ambasta, and Pravir Kumar. "Mitochondrial dysfunction and autophagy in neurodegeneration." In Mitochondrial Dysfunction and Nanotherapeutics, 139–78. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-323-85666-9.00019-x.
Full textKinch, Michael. "Autophagy." In Prescription for Change. University of North Carolina Press, 2016. http://dx.doi.org/10.5149/northcarolina/9781469630625.003.0011.
Full textMano, Tatsuo, and Atsushi Iwata. "Autophagy and Huntington’s disease." In Autophagy Dysfunction in Alzheimer's Disease and Dementia, 245–59. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-323-89906-2.00001-0.
Full textConference papers on the topic "Autophagy dysfunction"
Zhu, X. "Relationship Between Autophagy-Lysosomes Pathway and Ventilator-Induced Diaphragmatic Dysfunction." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2622.
Full textRodilla, Ananda Marina, Luis Korrodi-Gregório, Pilar Manuel-Manresa, Roberto Quesada, Ricardo Pérez-Tomás, and Vanessa Soto-Cerrato. "Abstract A05: Targeting autophagy through novel anionophores that induce lysosomal dysfunction." In Abstracts: AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.pmccavuln16-a05.
Full textHawkins, Arie, Ming Zhao, Michael F. Beers, and Surafel Mulugeta. "Mistargeted SP-C I73T Mutant Protein Induces Autophagy Block, Mitochondrial Dysfunction, And Intrinsic Apoptosis." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5097.
Full textVij, N., M. Bodas, G. Pehote, D. Silverberg, and E. Gulbins. "Autophagy Augmentation Alleviates Cigarette Smoke Induced CFTR Dysfunction, Ceramide Accumulation and COPD-Emphysema Pathogenesis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2832.
Full textGreven, J., Y. Shi, W. Guo, F. Bläsius, K. Horst, B. Relja, EM Buhl, and F. Hildebrand. "Trauma-hemorrhage: Mitochondrial dysfunction, autophagy and apoptosis in pig liver 72 h post polytrauma." In Deutscher Kongress für Orthopädie und Unfallchirurgie. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1717262.
Full textAbdelsalam, Shahenda Salaheldine, and Abdelali Agouni. "Protein Tyrosine Phosphatase (PTP) 1B Inhibition Improves Endoplasmic Reticulum Stress-Induced Apoptosis and Impaired Angiogenic Response in Endothelial Cells." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0110.
Full textFigueroa, P. Lόpez de, U. Nogueira-Recalde, V. Calamia, FG Osorio, M. Lotz, C. Lόpez-Otín, FJ Blanco, and B. Carames. "OP0008 Deficient autophagy induces chondrocyte dysfunction through lamin a/c accumulation in aging and osteoarthritis." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3819.
Full textChavez-Perez, Valery, Mary Strasberg-Rieber, and Manuel Rieber. "Abstract 2907: AMPK induction, lysosomal acidification and melanoma survival increased by p53 dysfunction are counteracted by inhibiting autophagy." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2907.
Full textLiang, Jiyong, Dexing Fang, and Amy B. Heimberger. "Abstract 1492: Chimeric antigen receptor (CAR) T cell donor dependent dysfunction modulation with activation of autophagy and inhibition of trogocytosis." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1492.
Full textBiel, Thomas, and Ashutosh Rao. "Abstract 1332: Autophagic clearance of protein aggregates is impaired in cancer cells with dysfunctional mitochondria." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1332.
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