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Schenström, Karl. "Biofunctionalization of a Fiber Optics-Based LSPR Sensor." Thesis, Linköpings universitet, Molekylär fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-125726.
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When exposed to light, metal nanoparticles exhibit a phenomenon known as LSPR, Localized Surface Plasmon Resonance. The wavelengths at which LSPR occurs is very dependent on the refractive index of the surrounding medium. Binding of biomolecules to the surface of gold nanoparticles result in a change in the refractive index that can be detected spectrophotometrically by monitoring the LSPR peak shift. When functionalized with the corresponding ligand(s), gold nanoparticles can be utilized in biosensors to detect the presence and concentration of a predetermined analyte. However, the system must exhibit high specificity and give rise to a detectable shift for analytes in the desired concentration range to be of commercial interest. The aim of the diploma project was to investigate and optimize the biofunctionalization and performance of a fiber optics based LSPR biosensor. Three ligand systems were investigated for detection of antibodies (IgG), insulin and avidin. Binding of the analyte to the ligand caused a shift of a few nanometers when using spherical gold nanoparticles. The shifts were significantly larger when using gold nanorods. When using the IgG and insulin ligands, only minor unspecific binding was observed. The setup thus shows great potential for use in a wide range of sensing applications.
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McCloughan, Troy Michael. "Burying aunt Billie and other stories." Diss., Click here for available full-text of this thesis, 2006. http://library.wichita.edu/digitallibrary/etd/2006/t078.pdf.
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Pine, Lila. "My Aunt Lila, a mad documentary." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0016/MQ59195.pdf.
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Berry, Mary Louise Morman Mark T. "Communication in the aunt/adult niece dyad." Waco, Tex. : Baylor University, 2007. http://hdl.handle.net/2104/5037.
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Koitmäe, Aune [Verfasser]. "Hybrid Neural Networks on Semiconductor Microtube Arrays / Aune Koitmäe." München : Verlag Dr. Hut, 2016. http://d-nb.info/1103872745/34.
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Manring, M. M. "Merchandising the mammy : the strange career of Aunt Jermina /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821353.
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Cardoso, Laylla Donata. "A systemic functional approach to experiential meaning construal in agony aunt columns." Florianópolis, SC, 2007. http://repositorio.ufsc.br/xmlui/handle/123456789/90111.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente.Made available in DSpace on 2012-10-23T06:15:37Z (GMT). No. of bitstreams: 1 238448.pdf: 881628 bytes, checksum: 355ad2c765eed1b2e6ff47b7beaab256 (MD5)
Nos dias atuais, há uma crescente necessidade de socializar problemas pessoais e, notavelmente, as revistas femininas são um bom veículo para o compartilhamento de experiências. Nesta dissertação, investigo um gênero textual específico em revistas femininas, as colunas de aconselhamento. A função principal dessas colunas é responder e aconselhar leitoras sobre questões pessoais, normalmente relacionadas a problemas conjugais envolvendo sexo e amor, assim como relacionamento entre amigos. Este estudo propõe uma investigação lingüística de duas colunas de aconselhamento publicadas na revista Glamour. O objetivo principal é mostrar como as experiências são representadas nas cartas das leitoras e também nas cartas de aconselhamento. Para esse fim, em uma macro aborgadem, a análise deste gênero textual revela a estrutura esquemática das cartas sob consideração. E, em uma micro abordagem, este estudo examina a representação de experiências realizadas pelas escolhas de transitividade. O arcabouço analítico aplicado a esta pesquisa baseia-se na teoria sistêmico-funcional, principalmente nos estudos de Halliday (1985, 1994) e Halliday & Matthiessen (2004). Os resultados do presente trabalho indicam que: 1) as colunas de aconselhamento publicadas na revista Glamour podem ser consideradas um gênero textual híbrido, no qual as cartas das leitoras apresentam características narrativas, enquanto as cartas de aconselhamento apresentam estrutura exortativa; 2) a análise da transitividade revela que: (i) até mesmo em uma dimensão profissional, as experiências femininas estão relacionadas a emoções e relacionamentos pessoais; (ii) os processos materiais, relacionais e mentais aparecem em maior número, indicando que as experiências são construídas geralmente por representações de ações, relações de atribuição/identidade e compartilhamento de sentimentos/pensamentos; (iii) esses processos associam as experiências femininas aos contextos privado e profissional, à idealização de soluções para os problemas expostos, e à ações abstratas; (iv) as leitoras se representam em papéis passivos, como "vítimas" socialmente oprimidas, visto que a conselheira é representada de maneira autoconfiante, como uma solucionadora de problemas. Os resultados desta pesquisa esperam contribuir para a conscientização dos leitores, estimulando-os a refletir sobre as práticas textuais vigentes, bem como fornecer ferramentas teórico-analíticas para que possam discutir e desvendar significados freqüentemente obscuros nos textos. In contemporary days, there seems to be a growing need to socialize personal problems, and notably, women's magazines appear to be a good vehicle for sharing experiences. In this thesis, I investigate a specific genre in women's magazines, the Agony Aunt Columns, also known as advice columns. The main function of Agony Aunt Columns is to answer readers' letters by providing pieces of advice on personal issues, normally related to love, sex, and relationships in general. The present study proposes a linguistic investigation of two Agony Aunt Columns, published on Glamour magazine. The main objective of this work is to show how experiential meanings are construed in both, advice-seeking and advice-giving letters. For that purpose, at a macro level, a genre analysis reveals the schematic structure of the letters under consideration. And, at a micro level, this study examines the representation of experiential meanings realized by the transitivity choices. The analytical framework applied to this research is based on Systemic Functional theory, mainly on the works of Halliday (1985, 1994) and Halliday & Matthiessen (2004). The results of this study indicate that: 1) Glamour Agony Aunt Columns may be considered an example of hybrid genre, in which advice-seeking letters present narrative features, while advice-giving letters resemble the structure of hortatory text-types; 2) the transitivity analysis of the two Agony Aunt Columns reveals that: (i) even in a workplace dimension, women's experiences are related to emotions and private affairs; (ii) material, relational and mental processes appear in a major number, indicating that women's experiences are construed mostly by representations of actions, relationships of being and sharing of feelings/thoughts; (iii) the processes associate women's experiences with identification in the two contexts (private and professional), idealization (the solutions for their problems), and with abstract and non-abstract actions; (iv) advice-seekers tend to represent themselves in passive roles, as "victims" socially oppressed, whereas the advice-giver is strongly represented as a reliable self-confident problem solver. The findings of this research hope to contribute to raise language awareness, stimulate readers to reflect on textual practices, as well as empowering them with theoretically-oriented analytical tools for discussing and unveiling often hidden textual meanings.
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Aune, Katherine Pearl. "Improving vocabulary instruction to increase student comprehension and science literacy." Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/aune/AuneK0812.pdf.
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This project was designed to investigate whether spending more class time and instructor planning time on teaching vocabulary would lead to improvement of student learning, attitude toward scientific vocabulary, and science literacy skills. Throughout the treatment the students spent more time working with terms chosen for each unit. This included activities that encouraged analysis of word meaning and comparison and analysis of relationships between terms. Summative assessments showed improvement in student comprehension along with increased confidence in their ability to perform lesson objectives. Additionally, the attitude students had toward science vocabulary and science literacy skills were more positive. The students also improved in their writing skills and use of appropriate terminology when working in groups and on projects.
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Aune, Matthew David. "Project FRESH." Thesis, Montana State University, 2010. http://etd.lib.montana.edu/etd/2010/aune/AuneM0510.pdf.
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Project FRESH is about creating a sustainable food system for our future. It is the goal of this project to design a large scaled environmentally controlled farm. The vision of this farm is to relieve many of the social and environmental stress that arise out of our current food systems. Furthermore this book is a compilation of research that investigates the problems and solutions that pertain to our modern food system. The first part of the book is research that expresses the current issues that exist with our food system today. This research will state and elaborate on the problems for which Project FRESH is attempting to combat. The second part of this book is the design proposal for Project FRESH. The design goal of this project is to create a fresh perspective on agriculture and its connection to the city. Creating a symbol for our future that patches agriculture back into our cities urban fabric. This symbol is to express the importances of locally grown food and its impact not only on the environment but its overall social and health benefits as well.
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Didó, Cezar Augusto. "Sílica Mesoporosa Modificada com Silsesquioxano Iônico como Suporte para Au (III) e AuNP." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/180645.
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Nesse trabalho foi feito um estudo comparativo de sílicas do tipo SBA-15 organofuncionalizadas com mercaptopropiltrimetoxisilano e/ou silsesquioxano iônico contendo o grupo 1,4-diazoniabiciclo[2,2,2]octano. Foram avaliadas as suas habilidades como estabilizadores e controladores de tamanho de nanopartículas de ouro, bem como a sua capacidade de ancoramento das nanopartículas no interior dos poros das sílicas, usando-se diferentes quantidades de ouro. Também foi avaliada a habilidade de um xerogel de sílica modificado com o mesmo silsesquioxano iônico, como suporte de íons Au (III) adsorvido via troca-iônica. Estes materiais foram caraterizados usando várias técnicas, tais como: análise elementar, termogravimetria, isotermas de adsorção-dessorção de nitrogênio, difração de raios X, espectroscopia na região do UV-Vis e do infravermelho e microscopia eletrônica de transmissão. Foi possível avaliar que o uso do silsesquioxano iônico leva a um maior controle na forma, no tamanho e na distribuição de tamanho das nanopartículas presentes nos poros das sílicas. Além disso, o silsesquioxano iônico se mostrou eficiente como ancorador de íons Au (III) na superfície de xerogel de sílica. A sílica contendo nanopartículas de ouro e íons Au (III) mostrou-se promissora para ser aplicada como catalisador heterogêneo.In this work, it was made a comparative study of organofunctionalized SBA-15 type silicas with mercaptopropyltrimethoxysilane and/or ionic silsesquioxane containing 1,4-diazoniabicyclo [2,2,2] octane group. Their abilities as stabilizers and size controllers for gold nanoparticles, as well as, the capacities to anchor nanoparticles inside of silica pores, using different amounts of gold, were evaluated. It was also studied a silica xerogel modified with the same ionic silsesquioxano, as adsorbent for Au (III) by ion-exchange. These materials were characterized using several techniques such as: elemental analysis, thermogravimetry, nitrogen adsorption-desorption isotherms, X-ray diffraction, UV-Vis and infrared spectroscopy, and transmission electron microscopy. It was possible to evaluate that the use of ionic silsesquioxane leads to a greater control in the shape, size and distribution of the nanoparticles present in the silica pores. In addition, the ionic silsesquioxane proved to be efficient as an adhesion agent of Au (III) ions on the silica xerogel surface. Silica containing gold nanoparticles and Au (III) ions showed promising results as heterogeneous catalysts.
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Lourenço, Sílvia de Castro. "The ten magic dwarves of aunt aquamarine : readings and the new editorial approach." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22107.
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Mestrado em Estudos EditoriaisThe present work intends to make a brief reflection about traditional oral tale in Portugal. A special emphasis was placed on the traditional tale The Ten Magic Dwarves of Aunt Aquamarine, including the study of part of its editorial history in three editions of the tale. These editions were made by three different publishers, in different periods of time and for that reason we can see the evolution that occurred in the editorial process. The last aim of this work was to present a new editorial proposal with a new and updated version of the story present in the tale. We concluded that the editorial market for Children Literature in Portugal is growing in the last decades. Today, a new generation of authors is giving renovated attention to it in close collaboration with other professionals, like designers and illustrators. In the basis of Children Literature was the traditional oral tales which carry symbols and myths of the past generations. These tales are often rewritten into new versions, with adaptations and updates that may convert them into Children’s Literature or into Adult Literature. Finally, editorial options, such as book size, illustrations or typefaces, also help to define the target audience of a publication. The edition process of a publication has several phases. Starting on a manuscript, which is revised several times, passing through all the book creation chain. Options taken until the book release to the market including not only design decisions, but also marketing and management decisions. Finally, the result of this work is the mockup of a small publication with the titled Did Aunt Aquamarine lend only ten magic dwarves to help? Its intention was to make an updated version which reflected a renovated look over the traditional oral tale under study in this work.
O presente trabalho tem como objetivo fazer uma breve reflexão sobre o conto tradicional em Portugal. Foi realizado o estudo do conto tradicional Os dez anõezinhos da Tia Verde-Água com principal ênfase nos aspetos editoriais de três versões diferentes, de três editoras diferentes e publicadas em diferentes períodos de tempo. Por fim, o último objetivo deste trabalho foi apresentar uma proposta editorial com uma nova versão da história presente no conto. Concluímos que o mercado editorial para a Literatura Infantojuvenil em Portugal continua a crescer. Hoje, uma nova geração de autores está a prestar atenção renovada a este campo editorial, em estreita colaboração com profissionais como designers e ilustradores. Na base da Literatura Infantojuvenil estiveram os contos tradicionais que carregam consigo símbolos e mitos de gerações passadas. Esses contos são muitas vezes reescritos, com adaptações e atualizações que podem convertê-los em Literatura Infantojuvenil ou em Literatura para Adultos. Finalmente, opções editoriais, como tamanho do livro, ilustrações ou tipos de letra, também ajudam a definir o público-alvo de uma publicação. O processo de edição de uma publicação tem várias fases. Começando por um original, que após aceitação e revisão, passa por toda a cadeia de edição até chegar ao leitor. As opções tomadas até ao lançamento do livro incluem não apenas decisões de design, mas também decisões de marketing e gestão. Por fim, o resultado deste trabalho é a maqueta de uma pequena publicação com o título Did Aunt Aquamarine lend only ten magic dwarves to help? Cumprindo assim o objetivo de fazer uma nova versão que refletisse um olhar renovado sobre o conto oral em estudo neste trabalho.
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Pernes, Tiago João Berenguer Alves Figueiredo. "Desenvolvimento de bionanoconjugados com nanopartículas de ouro e oxidases para a detecção de poluentes ambientais." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8160.
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Dissertação para a obtenção do grau de Mestre em BiotecnologiaO presente estudo teve como principal objectivo o desenvolvimento de um biossensor baseado em Tirosinase, com a conjugação de nanopartículas de ouro, para a detecção de pesticidas. O objectivo secundário foi verificar se os bionanoconjugados de Tirosinase e nanopartículas de ouro com diferentes agentes de revestimento, aumentavam a eficiência catalítica da Tirosinase,comparativamente com a enzima livre. Os ensaios em solução da actividade da Tirosinase livre e em bionanoconjugados, com diferentes agentes de revestimento – Citrato, ácido 11-mercaptoundecanóico (MUA) e o pentapéptido CALNN, numa gama de pH dos 4-8, permitiram concluir que a pH 4 e 5 a Tirosinase livre possui uma maior eficiência catalítica do que qualquer dos bionanoconjugados. Já a pH 6, 7 e 8 o bionanoconjugado revestido com CALNN é o que possui maior eficiência catalítica quando comparado com os restantes bionanoconjugados e Tirosinase livre, aumentando a actividade da Tirosinase em 26% a pH 6, em 6% a pH 7 e em 11% a pH 8. O biossensor de Tirosinase desenvolvido efectua a reacção de oxidação de compostos fenólicos a quinonas. A detecção de pesticidas é efectuada através da inibição da actividade de Tirosinase. O biossensor de Tirosinase foi desenvolvido sobre um eléctrodo de óxido de estanho dopado com fluoreto (FTO), à sua superfície foram sintetizadas nanopartículas de ouro por electrodeposição, com adição posterior de uma camada auto-montada de ácido 3-Mercaptopropanóico, que permitiu a ligação covalente da Tirosinase ao elétrodo por cross-linking com a ajuda dos compostos 1-Etil-3-(3-dimetilaminopropil)carbodiimida/ N-Hidroxisuccinamida. O biossensor foi caracterizado por microscopia electrónica de varrimento (SEM) e espectroscopia fotoelectrónica de Raio-X (XPS). Foi possível concluir que a electrodeposição do ouro ocorre com a formação de nanopartículas sobre o eléctrodo de forma uniforme sobre toda a sua área e a ligação da Tirosinase ao eléctrodo ocorre especificamente nas zonas do eléctrodo com nanopartículas de ouro e ácido 3-mercaptopropanóico sobre as mesmas. O composto fenólico seleccionado como substrato da Tirosinase foi o catecol. Para concentrações deste substrato superiores a 150 μM, determinou-se a ocorrência de inibição suicida da enzima, nas condições experimentais ensaiadas. A monitorização da reacção de oxidação de catecol com o biossensor desenvolvido foi efectuada com sucesso. Os resultados de voltametria cíclica com adição de pesticida (ácido 2,4 – diclorofenoxiacético(2,4-D)) permitiram concluir que a gama de concentrações detectável pelo biossensor desenvolvido é de 0,018-0,7 ng/mL, com uma inibição gradual do biossensor entre os 15 e 65 % de analito. O biossensor apresentou ainda um limite de detecção (LOD) de 0,0329±0,0144 ng/mL e uma concentração de saturação de aproximadamente 1 ng/mL para o analito em estudo.
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Ljung, Anna. "Challenges Facing Human Rights in Myanmar : Comparing 2004 and 2018." Thesis, Enskilda Högskolan Stockholm, Högskolan för mänskliga rättigheter, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ths:diva-169.
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Campos, Marcelo Leandro de. "Esoterismo, modernidade e seculariza??o: a Gnose de Samael Aun Weor." Pontif?cia Universidade Cat?lica de Campinas, 2015. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/755.
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Previous issue date: 2015-12-02This study aims to analyze the work of the Colombian esoteric Samael Aun Weor based on the concept of "secularization of esotericism" proposed by the historian Wouter Hanegraaff. Contributing to the interdisciplinary debate that articulates the field of Cultural History, History of Religions and the recent History of Western Esotericism, it is intended to analyze the reversing relations and mutual influences that guide the construction of the modern Western culture, its rationality paradigms and empirical science; and on the other hand, the establishment of an esoteric tradition that seeks to harmonize these paradigms with a design strongly "enchanted" of the universe, and the mutual process of appropriation/ reinterpretation involved.This debate also dialogues to a more specific discussion in the field of Science of Religions, which seeks to understand the changes occurring in Western religious field opposite the new secularized society. Specifically, this paper seeks to contribute to the debate by offering a perspective of these processes from its Latin American component in order to identify how these dynamics are reproduced on the continent and its specificities. With this purpose, taking the work of Samael Aun Weor as a case study, it was conducted a long-term historical context by inserting the author in a more general constitution process of modern Western esotericism, and specifically, in the constitution process of an esoteric spiritualities field in Colombia, birth cradle of the Gnostic Movement. From a historical-comparative analysis of his work evolution, its institutionalization and practices - which takes into account conceptual and methodological contributions of Italian History of Religions School, historiography on Western esotericism and theoretical proposition Bourdieu from the concept of "field" - the work highlights the doctrinal transition that the Colombian esoteric Aun Weor operates in his work, moving from Rosicrucianism towards the conceptions of a psychological esotericism, proposed by the Russian esoteric Gurdjieff. Such a transition is analyzed by the dominant imagery in the esoteric milieu of his time, a perspective that offers an important analytical material for understanding the structural dynamics that guide the institutionalization of Gnosticism in Latin America and the specifics that guide their reversing relations with the social universe in which they are inserted.
O presente trabalho tem o prop?sito de analisar a obra do esoterista colombiano Samael Aun Weor ? luz do conceito de seculariza??o do esoterismo do historiador Wouter Hanegraaff, que integra um importante debate, no campo da Hist?ria Cultural, que analisa as rela??es reversivas e as influ?ncias m?tuas que pautam, de um lado, a constru??o da moderna cultura ocidental e seus paradigmas de racionalidade e ci?ncia emp?rica, e do outro a constitui??o de uma tradi??o esot?rica que busca harmonizar estes paradigmas com uma concep??o fortemente encantada do universo, e dos m?tuos processos de apropria??o/reinterpreta??o envolvidos. Esse debate tamb?m dialoga com uma discuss?o mais espec?fica ao campo da Ci?ncia das Religi?es, que busca compreender as transforma??es que ocorrem no campo religioso ocidental frente ? nova sociedade secularizada. Nesse sentido, nosso trabalho busca contribuir com o debate oferecendo uma perspectiva destes processos a partir da periferia do ocidente , a Am?rica Latina, buscando identificar em que medida essas din?micas s?o reproduzidas no Novo Continente, e o que elas possuem de espec?fico. Com esse prop?sito, tomando-se a obra de Samael Aun Weor como estudo de caso, conduziu-se uma contextualiza??o hist?rica de longa dura??o, inserindo o autor no processo mais geral de constitui??o do moderno esoterismo ocidental, e de maneira mais espec?fica no processo de constitui??o de um campo de espiritualidades esot?ricas na Col?mbia. A partir de uma an?lise hist?rico-comparativa da evolu??o de sua obra, de sua institucionaliza??o e de suas pr?ticas, que leva em conta contribui??es conceituais e metodol?gicas da Escola Italiana de Hist?ria das Religi?es, nosso trabalho destaca a transi??o doutrin?ria que o autor opera em sua obra, deslocando-se do Rosacrucianismo em dire??o ?s concep??es de um Esoterismo Psicol?gico do esoterista russo Gurdjieff. Essa transi??o ? analisada ? luz do imagin?rio dominante no milieu esot?rico de sua ?poca, perspectiva que oferece um importante material anal?tico para a compreens?o das din?micas estruturais que norteiam a institucionaliza??o do gnosticismo na Am?rica Latina e das especificidades que definem suas rela??es reversivas com o universo social em que est?o inseridas.
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McMillin, Taylor Rae. "The Dangers of International Awards: A Lesson from Aung San Suu Kyi’s Nobel Peace Prize." Thesis, North Dakota State University, 2019. https://hdl.handle.net/10365/31631.
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Having spent over 20 years under house arrest fighting for democracy in Myanmar, Aung San Suu Kyi has been a bastion for peace for decades. She has received many international awards, including the Nobel Peace Prize in 1991, which she accepted in person in 2012. The plight of the Rohingya, a Muslim minority in Myanmar, has marred Suu Kyi’s reputation as a bastion of peace, leading to calls for her to lose her Peace Prize. Why is it that Suu Kyi’s image as the future of peace so different from reality? That question is what this research attempts to answer. Through a rhetorical analysis of Suu Kyi’s Nobel lecture and the media coverage that followed it, the impact of the use of tropes becomes evident. Metonymy, synecdoche, and narrative emerge in both the lecture and media coverage. Suu Kyi’s use of tropes heavily influences public perception of her.
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Abadias, Grégory. "Étude théorique et expérimentale de la métastabilité d'alliages AuNi déposés par épitaxie par jets moléculaires." Grenoble INPG, 1998. http://www.theses.fr/1998INPG0123.
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La croissance coherente en couches minces d'un materiau presentant un desaccord de parametre de maille avec le substrat sur lequel il est depose entraine des deformations du reseau cristallin qui sont a l'origine de nombreuses modifications thermodynamiques et structurales. La presente etude concerne l'effet des contraintes epitaxiales sur la stabilite d'alliages metalliques a separation de phases, en particulier le systeme auni qui presente une forte difference de taille (14%). La premiere partie est consacree a la modelisation thermodynamique des equilibres de phases coherents. Une extension de la theorie de cahn de la decomposition spinodale aux systemes epitaxies et a fort effet de taille a ete developpee. Les diagrammes d'equilibre de phases du systeme auni a l'etat massif et sous contrainte epitaxiale ont ete calculees a partir de la methode variationnelle des amas (cvm) limitee aux tetraedres. Pour de fortes deformations epitaxiales, une structure quadratique ordonnee de type l1#0 est stabilise pour des compositions proches de 50%. La deuxieme partie porte sur l'etude experimentale de couches minces d'alliages auni elabores par epitaxie par jets moleculaires (ejm) et sur leur evolution structurale au cours de traitements thermiques. Nous avons obtenu des solutions solides auni metastables. Le parametre pertinent est la deformation residuelle dans les couches auni. Les observations en diffraction de rayons x (xrd) et microscopie electronique haute resolution (mehr) montrent qu'une structure modulee, de periode 3 a 4 monocouches (mc), se stabilise pour de fortes deformations epitaxiales (>2%) et pour des temperatures comprises entre 200c et 240c. Ces structures modulees sont obtenues a partir d'etats initiaux tres differents (alliages, multicouches et structures artificielles), ce qui conforte l'hypothese de la stabilisation sous contrainte d'un ordre a longue distance dans un alliage ayant une forte tendance a la demixtion en volume.
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Brandão, Laila Natasha Santos. "Utilização da técnica de nanopartículas de ouro não modificada (AuNP) para detecção do agente da pleuropneumonia suína (Actinobaccilus pleuropneumoniae)." Universidade Federal de Mato Grosso, 2014. http://ri.ufmt.br/handle/1/534.
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A possibilidade de detecção de agentes patogênicos representou um grande passo para a ciência. O desenvolvimento e melhorias nas técnicas de diagnóstico como a técnica de Reação em Cadeia da Polimerase (PCR), ao longo dos anos ainda requer infraestrutura laboratorial, apesar de sua sensibilidade e custo decrescente, investimentos em equipamentos e cuidados com fontes de contaminação externa. Técnicas que possam ser executas com facilidade e pouca mão de obra ou exigência de pessoas capacitadas, têm grande possibilidades de aplicabilidade. Neste estudo desenvolveu-se uma técnica de rápida execução e baixo custo, para detecção de um dos principais agentes causadores de pneumonias em granjas de suínos o Actinobaccilus pleuropneumoniae, com sensibilidade 93,8% e especificidade de 84,6% em amostras de pulmões com e sem lesão. O teste Kappa entre a PCR e nanopartícula de ouro foi 0,684 representando boa concordância. A técnica pode ser utilizada como alternativa aos testes convencionais, já que é de fácil e rápida execução e não exige infraestrututra e mão de obra especializada.
The possibility of detection of pathogens was a major step for science as a whole, developing and improving these techniques over the years to increase visibly. The development of the technique of Polymerase Chain Reaction ( PCR ) , although its sensitivity and decreasing cost over the years, it's still a handy little technique that requires laboratory infrastructure, high investments in equipment and care with sources of external contamination. Techniques that can be performed through the ease and little manpower or requirement of skilled people, always have great scope of applicability. This study develops a technique for quick and low- cost detection of a major causative agent of pneumonia in swine herds the Actinobaccilus pleuropneumoniae , with 93.8 % sensitivity and 84.6% specificity in samples of lungs with and without injury, the Kappa test between PCR and gold nanoparticle was 0,684 representing good agreement . The technique can be used as an alternative to conventional tests, since it is easy and quick to implement and does not require infrastructure and skilled labor.
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Guerreiro, Márcia Cordeiro. "A Birmânia e a Luta pela Democracia : 1988-2010." Master's thesis, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa, 2012. http://hdl.handle.net/10362/8676.
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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Ciência Política e Relações Internacionais, Especialização em Relações Internacionais.Esta dissertação de mestrado versa sobre a problemática da luta pela democracia na Birmânia, no período compreendido entre 1988 e 2010. A nossa análise baseia-se em três eixos: o interno, o internacional e o regional. O primeiro capítulo aborda a questão da luta interna que visa a mudança para um regime político democrático, despoletada pela revolta popular de 1988 e a evolução da situação política interna. O segundo capítulo analisa a reação externa, por parte dos Estados Unidos, da União Europeia, do Japão e das Nações Unidas, relativamente ao movimento democrático birmanês e à continuação do governo militar. O terceiro capítulo trata da abordagem regional à questão da mudança política na Birmânia e em relação ao regime do SLORC/SPDC, por parte da China, da Índia, da Tailândia e da ASEAN.
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Thaw, Tar Aung Verfasser], and Klaus Jan [Akademischer Betreuer] [Philipp. "Aspekte zur Tempelarchitektur in Myanmar : eine Beurteilung des räumlichen Aufbaus / Tar Aung Thaw. Betreuer: Klaus Jan Philipp." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2013. http://d-nb.info/1045604380/34.
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DRESSLER, CYRIL. "Etude par microscopie electronique de l'evolution en temperature des couches minces metalliques contraintes dans le systeme auni." Paris 6, 1998. http://www.theses.fr/1998PA066474.
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Dans ce travail, nous avons utilise la microscopie electronique in-situ et ex-situ afin d'analyser l'evolution structurale de couches minces metalliques auni sous traitement thermique. Le systeme auni est en effet un excellent modele pour la comprehension des phenomenes gouvernant les systemes a tres forts desaccords parametriques (15%). Les couches minces sont elaborees a temperature ambiante par epitaxie par jets moleculaires, leur direction de croissance etant selon l'axe 001. Elles sont de deux types : soit le ni est depose pur sur au001, soit les deux especes au et ni sont codeposees sur au001. Dans les deux cas, il y a formation d'un alliage auni en couches minces, contraint par le substrat d'or. L'etude par mehr couplee a la simulation d'images a permis de mettre en evidence la formation sous traitement thermique d'une phase anisotrope et partiellement ordonnee dans l'alliage au 1 cni c. Cette phase apparait quel que soit le type de depot, et pour des concentrations c telles que 0. 28
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Thaw, Tar Aung [Verfasser], and Klaus Jan [Akademischer Betreuer] Philipp. "Aspekte zur Tempelarchitektur in Myanmar : eine Beurteilung des räumlichen Aufbaus / Tar Aung Thaw. Betreuer: Klaus Jan Philipp." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2013. http://d-nb.info/1045604380/34.
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Ker, Yin. "Figurer, voir et lire l’insaisissable : la peinture manaw maheikdi dat de Bagyi Aung Soe (1923/24–1990)." Thesis, Paris 4, 2013. http://www.theses.fr/2013PA040144.
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Héritier de l’universalisme humaniste de Rabindranath Tagore par sa formation à Śāntiniketan en Inde, le ditpère de l’art moderne birman Bagyi Aung Soe (1923/24–1990) se consacra à figurer les réalités ultimes enfonction des enseignements bouddhiques. Pour ce faire, il mit au point un langage pictural qu’il baptisa lapeinture « manaw maheikdi dat » qui signifie la création artistique par la culture mentale. Ses référencesvisuelles, variant de la physique à l’ésotérisme bouddhique, de la culture populaire à la poésie, comprennent toutce qui fut à sa portée intellectuelle et spirituelle dans la Birmanie socialiste militaire de 1962 à 1988. Soninsistance sur la somme des héritages propres à cet espace-temps, de même que son dépassement descloisonnements conceptuels selon les disciplines, les frontières nationales ou les divisions chronologiques, exigeun récit conçu au regard des significations contextuelles, un récit adapté et affranchi du modèle prétendumentinternational de l’art euraméricain. Afin de proposer un récit sur comment il compta rendre manifestel’insaisissable selon les circonstances propres au contexte de sa vie, nous mettons l’accent sur les conditionsaccueillant la genèse et la diffusion de cette production artistique dite « la plus moderne de l’art moderne » enraison de sa dimension transnationale et transhistorique. À partir d’une sélection parmi plus de quatre milleoeuvres et de centaines de témoignages écrits et oraux recueillis, nous examinons non seulement la fabrication decette peinture qui reste aussi non étudiée en Birmanie qu’inconnue de la scène internationale, mais aussi lesmanières dont nous pouvons la lire et la voirA student at Rabindranath Tagore’s ashram in Śāntiniketan, India, Myanmar’s “father of modern art” BagyiAung Soe (1923/24–1990) embraced his Indian gurus’ concept of art and the artist. In the spirit of the laureate’shumanist universalism, he strove to picture Buddhist teachings. His signature idiom christened “manawmaheikdi dat”, which has yet to be studied in Myanmar and is virtually unknown at the international level, reliedon meditation to achieve advanced mental power in order to picture the most elemental components of allphenomena, and its visual references included all that was possibly accessible under socialist rule in Burma(1962–1988). With little regard for artistic conventions and categorisations according to discipline, nation andchronology, Aung Soe drew from the sum of artistic, intellectual and spiritual traditions defining his space andtime, varying from quantum physics to esoteric Buddhism, from popular culture to poetry. The nature of hisapproach, method and subject matter, coupled with his country’s exceptional circumstances, demands a newnarrative of art that is unfettered by the assumptions inherent to the purportedly international framework ofEuramerican modern art. Focusing on the contextual significances of the genesis and reception of manawmaheikdi dat painting, this dissertation examines the making, the reading and the seeing of this pictoriallanguage whose transnational and transhistorical dimension renders it “the most modern of modern art”. Basedon a selection of the artist’s works and writings, as well as witnesses of his life and practice, we attempt a storyof how he pictured and made manifest the formless on his own terms
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Godoy, Junior Ederaldo [UNESP]. "Desenvolvimento e avaliação de uma miniestação ecoeficiente de tratamento de esgoto e reuso de águas, com sistemas registrador queimador, para baixa vazões de biogás e cogeração de energia." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/106459.
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godoyjunior_e_dr_guara.pdf: 1961718 bytes, checksum: 5a6eed31632ec8bdfaa7ca03a55195ef (MD5)O presente trabalho trata do desenvolvimento, do processo construtivo, da implantação e da análise técnica, econômica e ambiental de uma miniETERA (miniestação ecoeficiente de tratamento de esgoto e reuso de águas), em PVC e concreto armado, associada a um sistema de cogeração de energia a biogás e a um sistema registrador e queimador de biogás para baixas vazões. A miniETERA é composta por três digestores anaeróbios de fluxo ascendente, em manto de lodo, do tipo UASB (upflow anaerobic slodge blancket) modificado, dispostos em série, formando cascata, seguido de um digestor híbrido aeróbio (com ar) e anóxio (sem ar na presença de nitrato). Para efeito do trabalho foi avaliada a eficiência dos reatores UASB, cuja redução média da DQO (demanda química de oxigênio) do efluente foi de 80,1%, sem a utilização de elementos eletromecânicos. O biogás produzido pelo sistema apresentou concentração média de 57,99% de metano no UASB I, devida à hidrólise, e de 80,45% de metano no UASB II, devida essencialmente à atividade metanogênica. O sistema compacto de cogeração de energia desenvolvido é composto por um motogerador de potência nominal de 5,5 kW a gasolina, convertido a biogás e/ou gás natural a baixa pressão (GNBP), acoplado a um trocador de calor gás/água, para a geração de energia elétrica e água quente. O cogerador compacto foi testado experimentalmente, utilizando biogás oriundo do tratamento anaeróbio de resíduo avícola, com uma porcentagem de 60% de metano; obteve-se uma potência útil de 2,6 kW e, no caso do uso de GNBP, a partir de GNV (gás natural veicular) despressurizado, obteve-se uma potência útil de 4,2 kW. O reuso de água foi feito por meio de sistema de fertirrigação de um bosque em 12 formação, com o efluente tratado. A análise técnica e econômica...
This paper deals with the development of the constructive process, and deployment of technical, economic and environmental dimensions of a EMSTWR (ecoefficient ministation of sewage treatment and water reuse), PVC and concrete, coupled with a cogeneration system to biogas energy system and a recorder and burner biogas for low flow. The Miniet is composed of two anaerobic digesters in upflow sludge blanket, UASB type (Upflow Anaerobic slodge blancket) modified, arranged in series forming cascade, followed by an aerobic digester Hybrid (air) and anóxio (no air in the presence nitrate) for the purpose of this study was to evaluate the efficiency of UASB reactors, whose average reduction of COD (chemical oxygen demand) of the effluent was 80.1% without the use of electromechanical components. The biogas produced by the system showed an average concentration of 57.99% methane in UASB I, due to hydrolysis, and 80.454% methane in UASB II, mainly due to methanogenic activity. The compact cogeneration power developed is composed of a motogenerator rated at 5.5 kW gasoline, or converted to biogas and natural gas at low pressure (NGLP) coupled to a heat exchanger gas / water for the generation electricity and warm water. The compact cogenerator was tested experimentally using biogas originating from anaerobic treatment of poultry manure, with a percentage of 60% methane, we obtained an output of 2.6 kW, and in case of using NGLP from NGV (Natural Gas Vehicle) depressurized, we obtained an output of 4.2 kW. Reuse of water was done through fertigation system in formation of a forest, with the treated effluent. A technical and economic analysis of EMSTWR compared with traditional systems of 14 sewage treatment, was interesting from the standpoint of environmental, energy and economic... (Complete abstract click electronic access below)
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Luz, João de Brito Correia da. "Bionanoconjugados de Citocromo Tri- hémico e nanopartículas de Ouro para biorremediação de Cr(VI)." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6217.
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Dissertação para a obtenção do grau de Mestre em BiotecnologiaO presente estudo teve como principal objectivo estudar a formação de bionanoconjugados capazes de efectuar a biorremediação de Cr(VI), conjugando a capacidade de redução de Cr(VI) de uma proteína tri-hémica, PpcA, isolada de Geobacter sulfurreducens,com nanopartículas de ouro revestidas com ácido 11-mercaptoundecanóico (AuNP-MUA). A proteína PpcA foi obtida através de um sistema de sobrexpressão recombinante em Escherichia coli e purificada utilizando técnicas cromatográficas de permuta iónica e exclusão molecular. As AuNP foram sintetizadas seguindo o método de redução por citrato formando uma solução de ouro coloidal em meio aquoso. A formação dos bionanoconjugados foi caracterizada por diversas técnicas, nomeadamente medições de potencial zeta, electroforese em géis de agarose e espectroscopias de UV/Visível e de Ressonância Magnética Nuclear. Através destas técnicas foi possível comprovar a formação dos bionanoconjugados e determinar a quantidade de PpcA necessária para revestir totalmente a superfície das AuNP, concluindo-se que são necessárias 200 moléculas de PpcA para revestir totalmente a superfície de uma nanopartícula de ouro com um diâmetro médio de 15 nm. Foi possível também, através de espectroscopia de Ressonância Magnética Nuclear, determinar qual a região de interacção entre a PpcA e as AuNP. Esta região situa-se na vizinhança do hemo IV e envolve três segmentos de cadeia polipeptídica que incluem os resíduos 8-13, 44-48 e 67-71. A estabilidade dos bionanoconjugados relativamente à agregação induzida pelo aumento da força iónica e pH foi avaliada por espectroscopia de UV/Visível determinando-se que os bionanoconjugados com uma razão [PpcA]/[AuNP-MUA] igual a 200 são estáveis a concentrações de NaCl até 1 M e a valores de pH superiores a 7 e inferiores a 11. A capacidade redutora de Cr(VI) da PpcA foi avaliada por voltametria cíclica após imobilização da proteína num eléctrodo de óxido de estanho dopado com fluoreto (FTO) modificado com ouro nanoestruturado. Determinou-se que a PpcA é capaz de reduzir eficazmente o Cr(VI) a Cr(III) devido ao efeito catalítico desta proteína no processo de transferência electrónica.
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CARRILLO, CAZARES ANDRES 732305, and CAZARES ANDRES CARRILLO. "Evaluación teórica-experimental del cambio de temperatura en tejido por efecto fototérmico plasmónico del sistema 177Lu-AuNP-RGD." Tesis de maestría, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/68705.
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The working group of National Laboratory of Research and Development of Radiopharmaceuticals (LANIDER) from ININ has developed radiopharmaceuticals for diagnosis and therapy at last for the last 20 years. Recently it developed a radiopharmaceutical based on gold nanoparticles (AuNPs) functionalized with the peptide sequence Arg-Gly-Asp (RGD). The RGD sequence has shown a high affinity for avB3 integrins over-expressed in various cancer cells. When AuNPs are exposed to electromagnetic radiation as laser light, the surface plasmon resonance (SPR) effect is induced, in which the free electrons absorb and disperse to light. These processes are described by Mie theory, which determines the probability of the process by its effective sections Cabs and Csca and considers the sum of these as effective extinction section Cext. Cabs is directly related to the heat production generated by the AuNP (with a temperature range of -+ 800 C) and has been shown to cause irreversible thermal cell destruction due to uncontrolled temperature increase, a process called Plasma Photothermal Therapy. Therefore, the overall objective of this project was to theoretically evaluate the change in tissue temperature by the presence of the AuNP-RGD conjugate when irradiated with laser light using a heat diffusion model that considers the absorption, dispersion and extinction coefficients of the system. Likewise, the theoretical value was correlated with the experimental value obtained when irradiating the system with laser light of 532 nm. The development of this project was planned in two phases, one theoretical and one experimental. In the first, Cabs , Csca and Cext were determined by Mie theory, considering the AuNP-RGD in water and tissue (Liver and Colon). In the second, samples of AuNP-RGD were irradiated in water and tissue with a pulsed Nd: YAG laser at a wavelength of 532nm and variable repetition frequencies (5, 10 and 15 Hz) and temperature was monitored every second using a thermocouple, temperature vs time graphs were constructed and a model of temperature distribution was proposed between the theoretical and experimental data. From Mie theory it was determined that Cext obtained at 532nm for different samples does not represent the maximum value, otherwise, for AuNP-RGD in water, colon and liver are respectively 94%, 98% and 96% of their maximum value obtained at 522.5 nm and 525 nm. From experimental part, it was determined that temperature increase at macroscopic level is about 13 C with a concentration of 6.54x1011 AuNP /mL after an irradiation of 200s at a 10Hz frequency and after 90s at 15 Hz frequency. Using temperature vs time curves a temperature model was constructed based on theoretical values of Cabs and a mass loss correction factor describing the behavior at the macroscopic level of the system. As a conclusion of this project, we have that calculations of Cabs , Csca and Cext for (AuNP-RGD)-water, (AuNP-RGD)-colon and (AuNP-RGD)-liver help to understand temperature increase observed when they are irradiated with laser light at 532 nm. Observed temperature increase was approximately 13 °C which is sufficient to produce cell death by plasmonic photothermal therapy.El grupo de trabajo del Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos (LANIDER) del ININ desarrolla desde hace más de 20 años radiofármacos para diagnóstico y terapia. Recientemente desarrolló uno basado en nanopartículas de oro (AuNPs) funcionalizadas con la secuencia peptídica Arg-Gly-Asp (RGD). La secuencia RGD ha mostrado una gran afinidad por las integrinas avB3 sobre expresadas en diversas células de cáncer. Cuando las AuNPs se exponen a radiación electromagnética como luz láser, se induce el efecto de resonancia de plasmón de superficie (SPR), en este, los electrones libres absorben y dispersan a la luz. Estos procesos son descritos por la teoría de Mie, la cual determina la probabilidad del proceso mediante sus secciones eficaces Cabs y Csca, y considera a la suma de éstas como la sección eficaz de extinción Cext. La 𝐶𝑎𝑏𝑠 está directamente relacionada con la producción de calor que genera la AuNP (con un alcance de temperatura de +- 800 grados centigrados ) y se ha demostrado que causa destrucción celular térmica irreversible por el aumento incontrolado de temperatura, proceso denominado Terapia Fototérmica Plasmónica. Por lo anterior, el objetivo general de este proyecto fue evaluar teóricamente el cambio de temperatura en tejido por la presencia del conjugado AuNP-RGD al ser irradiado con luz láser mediante un modelo de difusión de calor que considera los coeficientes de absorción, dispersión y extinción del sistema. De igual manera, el valor teórico se correlacionó con el valor experimental obtenido al irradiar dicho sistema con luz láser de 532 nm. El desarrollo de este proyecto se planteó en dos fases, una teórica y una experimental. En la primera, se determinaron los Cabs , Csca y Cext mediante teoría Mie, considerando a las AuNP-RGD en agua y tejido (hígado y colon). En la segunda se irradiaron muestras de AuNP-RGD en agua y tejido con un láser pulsado de Nd:YAG a una longitud de onda de 532 nm y frecuencias de repetición variables (5, 10 y 15 Hz) y se monitoreó la temperatura cada segundo usando un termopar, se construyeron las gráficas de temperatura vs tiempo y se planteó un modelo de distribución de temperatura ente los datos teóricos y los experimentales. De la teoría Mie se determinó que el Cext obtenido a 532 nm para las diferentes muestras no representa el valor máximo, sino, el 94%, 98% y 96% de su valor máximo para AuNP-RGD en agua, colon e hígado respectivamente, obtenidos a 522.5 nm y 525 nm. En la parte experimental se determinó que el incremento de temperatura a nivel macroscópico después de una irradiación de 200 s a una frecuencia de 10 Hz ó 90 s a una frecuencia de 15 Hz es alrededor de 13°C para una concentración de 6.54x1011AuNP/mL. A partir de las curvas de temperatura vs tiempo se construyó un modelo de una temperatura basado en los valores teóricos de Cabs y un factor de corrección por pérdida de masa que describe el comportamiento a nivel macroscópico del sistema. Como conclusión de este proyecto tenemos que los cálculos de los Cabs, Csca y Cext para (AuNP-RGD)-agua, (AuNP-RGD)-colon y (AuNP-RGD)-hígado ayudan a entender el incremento de temperatura observado cuando son irradiados con luz láser de 532 nm. El incremento de temperatura fue suficiente para producir muerte celular por terapia Fototérmica Plasmónica.
CATEDRÁS-CONACyT-ININ-337 CONACYT-SEP-CB-2014-01-242443.
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Reum, Nico [Verfasser], and Claus-Michael [Akademischer Betreuer] Lehr. "Multilayer coating of gold nanoparticles (AuNP) with drug-polymer complex : development and characterization / Nico Reum. Betreuer: Claus-Michael Lehr." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051284856/34.
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Pagani, Rafael Marcelo. "Reforma do estado e reestruturação territorial : a rede de gasodutos na aglomeração urbana do nordeste do Rio Grande do Sul e suas repercussões sociais e econômicas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/14876.
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A presente pesquisa faz uma análise do processo de reestruturação territorial no Brasil tendo como base as novas funções do Estado face às mudanças econômicas e políticas ocorridas em escala mundial denominadas de globalização ou mundialização do capital. O foco principal do trabalho é a diversificação da matriz energética brasileira com o início do uso do Gás Natural (GN) nos processos industriais e comerciais da região da Aglomeração Urbana do Nordeste do Rio Grande do Sul – AUNE, que engloba dez municípios e mais de 800 mil habitantes e se constitui na segunda maior aglomeração urbana do estado. Foram desenvolvidas pesquisas de campo nas oficinas mecânicas credenciadas pelo INMETRO aptas a fazerem conversões de veículos automotivos para o uso do gás natural e em empresas que utilizam o gás natural em seus processos produtivos. A pesquisa procurou traçar uma visão geral das transformações sociais e econômicas que o uso dessa nova fonte energética trouxe para a AUNE.The present research analyzes the territorial restructuring process in Brazil, based on the new State's functions in light of global economic and political changes. The principal focus of the study is the Brazilian energy matrix's diversification, beginning with the of the use of natural gas in industrial and commercial process in northeastern Rio Grande do Sul (AUNE), which comprises ten cities and more than 800,000 people. It is the second biggest urban region in the state. Field research was developed in the mechanical workshops licensed by INMETRO to make the conversion to natural gas in vehicles and companies that utilize it in their production process. The research objective was to evidence a global vision of the economic and social changes that the use of this new energy source has brought to AUNE.
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Morse, Kimberly Jane. "Aun en la muerte separados : class, clergy, and society in Aragua de Barcelona, Venezuela, 1820-1875 /." Digital version:, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992878.
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Thesis (Ph. D.)--University of Texas at Austin, 2000.Vita. Two folded genealogical tables in pocket. Includes bibliographical references (leaves 425-436). Available also in a digital version from Dissertation Abstracts.
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Aung, Yee Mon [Verfasser], and Manfred [Akademischer Betreuer] Zeller. "An economic analysis of fish demand and livelihood outcomes of small-scale aquaculture in Myanmar / Yee Mon Aung ; Betreuer: Manfred Zeller." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2021. http://d-nb.info/1235068617/34.
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Peschiera, Mifflin Diego. "El leasing o arrendamiento financiero y el financiamiento de proyectos : potencialidades aun sin explotar en el Perú." IUS ET VERITAS, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/123138.
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Wehbe, Nimer Fallavier Mireille. "Émission ionique des solides à l'impact d'agrégats Aun+ (n=1-9) accélérés entre 0.15 et 1.25 MeV." [s.l.] : [s.n.], 2006. http://tel.archives-ouvertes.fr/docs/00/09/76/71/PDF/Thesewehbe.pdf.
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Aung, Thiha [Verfasser]. "Die Bedeutung der Modulation der Exosomensekretion durch den ABC-Transporter A3 für die intrinsische Zytostatikaresistenz von aggressiven B-Zell-Lymphomen / Thiha Aung." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1224352971/34.
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Renaud, Gilles. "Ordre chimique et désordre topologique dans les solutions solides AuNi : étude par résistivité et par absorption et diffusion du rayonnement synchrotron X." Grenoble 1, 1988. http://www.theses.fr/1988GRE10134.
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Caracterisation precise de la tendance a l'ordre a courte distance dans le monocristal au::(80) ni::(20): l'alliage est aleatoire en premier voisin, mais il existe une faible tendance a l'homocoordination en second voisin. Determination dans tout le domaine de composition des valeurs des trois distances moyennes partielles ainsi que de la largeur et de l'asymetrie de leur distribution. Mesure de l'effet de coeur dans les alliages dilues. Simulation par ordinateur des distorsions du reseau. Evaluation selon un modele harmonoque de l'energie elastique
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Renaud, Gilles. "Ordre chimique et désordre topologique dans les solutions solides AuNi étude par résistivité et par absorption et diffusion du rayonnement synchrotron X /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37617977b.
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Wehbe, Nimer. "Émission ionique des solides à l'impact d'agrégats Aun+ (n=1-9) accélérés entre 0. 15 et 1. 25 MeV." Lyon 1, 2006. http://tel.archives-ouvertes.fr/docs/00/09/76/71/PDF/Thesewehbe.pdf.
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Ce travail expérimental est consacré à l'étude de l'émission ionique des solides à l'impact d'agrégats d'or d'énergie variant entre 0,15 et 1,25 MeV. La physique des collisions ion-solide et les modèles théoriques de la pulvérisation des solides par bombardement ionique sont présentés dans le chapitre 1. Le chapitre 2 est consacré à la description du dispositif expérimental. L'étude d'une cible d'or, présentée dans le chapitre 3, a permis de montrer le rôle de la taille et de l'énergie des agrégats sur l'intensité de l'émission et la distribution de masse des ions. Le chapitre 4 présente l'étude de l'iodure de césium dans laquelle l'intense émission des agrégats de CsI a pu être quantifiée grâce à des mesures de la multiplicité de l'émission. Le chapitre 5 est consacré à l'étude d'une molécule biologique, la phénylalanine, et d'une molécule de pesticide, le chlorsulfuron. Ce travail met en évidence l'intérêt des agrégats en analyse de surface par spectrométrie de masseThis experimental work is devoted to the study of the ion emission of solids under the impact of gold clusters of energy ranging between 0. 15 and 1. 25 MeV. The physics of ion-solid collisions and the theoretical models of solid sputtering by ion bombardment are presented in chapter 1. Chapter 2 is devoted to the description of the experimental setup. The study of a gold target, presented in chapter 3, allows us to show the role of the size and the energy of the clusters on the intensity of the emission and on the mass distribution of the ions. Chapter 4 presents the study of cesium iodide in which the intense emission of CsI clusters has been quantified from measurements of the emission multiplicity. Chapter 5 is devoted to a study of a biological molecule, phenylalanine, and a molecule of pesticide, the chlorsulfuron. This work points out the interest of clusters for surface analysis by mass spectrometry
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Saulnier, Emmanuelle. "La participation des parlements français et britannique auw communautés et à l'Union européenne : lecture parlementaire de la construction européenne." Paris 1, 2000. http://www.theses.fr/2000PA010339.
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Il est d'usage, des lors que les parlements nationaux sont évoqués dans le cadre des communautés et de l'union européennes, de déplorer la passivité de leurs rôles, et même l'affaiblissement des institutions démocratiques nationales auquel la construction européenne aurait contribué. Ce constat ne résiste pas longtemps à l'examen, puisqu'il apparait que les parlements nationaux sont des rouages essentiels du processus décisionnel de l'union, de l'origine de ce processus, c'est-à-dire à compter de l'autorisation parlementaire de ratification des traités institutifs, à la mise en œuvre de ce processus, c'est-à-dire au moment de l'adoption de textes nationaux d'application du droit dérivé. Au sein des communautés puis de l'union européennes, tout semblait cependant opposer les parlements français et britannique : le premier était réputé bridé par les dispositions de la constitution de 1958, alors que le second était décrit comme omni compétent, en application de la théorie de la souveraineté parlementaire ; le premier a subi concomitamment les influences croisées de la constitution de 1958 et des traites de Rome de 1957, alors que le second a pu bénéficier de l'expérience acquise par ses homologues avant l'adhésion du Royaume-Uni. Aujourd'hui encore, le premier fait partie d'un état qui participe à toutes les politiques communautaires et intergouvernementales, alors que le Royaume-Uni s'est vu octroyer des clauses d'exemption dans des domaines essentiels ; il en découle une idée couramment répandue mais inexacte qui voudrait que le parlement français ait toujours baigne dans une ambiance favorable à la construction européenne, alors que le parlement britannique ne pourrait qu'afficher des positions hostiles à tout approfondissement de l'intégration.
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Datta, Sayak. "Synthesis of gold nano-particles in a microfluidic platform for water quality monitoring applications." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3189.
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Gryder, Berkley Eric. "New insights into targeting the androgen receptor for cancer therapy: from selective delivery of gold nanoparticles and histone deacetylase inhibitors, to potent antagonists and inverse agonists." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52926.
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Cancer is the second leading cause of death in the United States (more than half a million people each year), and even with billions of dollars in medical effort patients are rarely cured. This dissertation research is devoted to meeting this medical need by providing new cancer therapeutics that are more potent and safer than current chemotherapies. This is achieved by using two state of the art anticancer “warheads”: 1) gold nanoparticle (AuNP) technology and 2) a new class of epigenetic anticancer small molecules, histone deacetylase inhibitors (HDACi). These warheads are then selectively delivered to cancer cells via “homing devices” targeted to receptors that are overexpressed in the cancers.
This work primarily focuses on the androgen receptor (AR) to target prostate cancer.
The 1st chapter sets the stage, providing scientific rationale and background for the central hypothesis: small molecules that engage the AR can, upon conjugation to a therapeutic agent, enable selective delivery of that agent to prostate cancer cells.
Chapter 2 delves into the structural molecular biology of the androgen receptor. There is a survey of the crystallographic data for all nuclear receptors, providing structural information which is used to build AR homology models for antagonist and inverse agonist modes of ligand binding. These models are used to design AR targeting ligands (Chapters 3, 5, 6 and 7).
The application of the targeting technology is illustrated by attaching them to AuNPs for selective delivery to prostate cancer cells (Chapter 3). Next, in order to appreciate the importance of using targeting agents in HDACi cancer therapeutics, we reviewed this recently emerged field in Chapter 4. In this chapter we argue that the failure of HDACi in solid tumors, despite more than 500 clinical trials in the last decade, is primarily due to an inability of these small molecules to accumulate at effective concentrations in the cancer. We provide an analysis of the paradigms being pursued to overcome this barrier, including HDAC isoform selectivity, localized administration, and targeting cap groups to achieve selective tissue and cell type distribution. In Chapter 5, this last approach (targeting cap groups, or a “homing device”) is illustrated with HDACi targeted to prostate cancer via antiandrogens that bind the AR. The second generation of improved “homing devices” is disclosed in Chapter 6 (for both AuNPs and HDACi), in addition to preliminary ADMET data and safety studies in mice.
Excitingly, our three dimensional understanding of binding to the AR allowed design and structure-activity-relationship studies that lead to the first reported examples of AR inverse agonists (Chapter 7)
Several points of significance:
• AuNP targeted to AR
∙ have the strongest binding affinity ever reported (IC50 ~14 picomolar)
∙ are actively recruited to prostate cancer cells
∙ overcome treatment resistance in advanced prostate cancer cells
∙ exhibit nanomolar anticancer potency
∙ resolved the identity of the “membrane AR” as the GPRC6A
• HDACi targeted to AR
∙ have HDACi activity and AR binding affinity superior to their clinical precursors
∙ exhibit potent AR antagonist activity
∙ induce AR translocation to the nucleus in a HDACi dependent fashion
∙ selectively and potently kill prostate cancer cells that express AR
∙ are safer than Tylenol®, as tested in small animals
• Pure AR binding ligand studies
∙ resulted in the discovery of the first examples of AR inverse agonists, which are vastly more potent that clinically available antiandrogens for prostate cancer
∙ work via a never-before-seen mechanism of action, by localizing to the nucleus and recruiting corepressors to actively shut off AR genes
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Lavenn, Christophe. "Les thiolates d'or : des polymères de coordination [Au(SR)]n luminescents aux clusters [Aun(SR)m] pour la catalyse hétérogène." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10256.
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Les nanoparticules d'or de petite taille (< 5 nm) sont des matériaux qui présentent une bonne activité catalytique dans des réactions d'oxydation, et ce dans des conditions relativement douces. Cependant, il est difficile d'obtenir des nanoparticules monodisperses et de taille inférieure à 5 nm. En ce sens, les clusters d'or sont intéressants, car ce sont des composés atomiquement définis avec une formulation propre. Cela signifie que dans un cluster, le nombre d'atomes d'or et de ligands le stabilisant est déterminé. Comme ils peuvent être isolés purs, ils constituent donc une classe de nanoparticules parfaitement monodisperses. Nous nous sommes intéressés, dans le cadre de cette thèse, à la synthèse de clusters d'or et à leur assemblage afin d'avoir des catalyseurs atomiquement définis. Les nanoparticules d'or sont souvent utilisées après dépôt sur un support, résultant en la perte de surface accessible. Nous voulons donc utiliser ces clusters (i) comme espèces moléculaires déposées sur un support et (ii) comme briques moléculaires pour l'assemblage de réseaux tridimensionnels où la porosité permettrait la diffusion des réactifs/produits pour s'affranchir des effets de supports. Notre étude porte donc sur la synthèse de clusters d'or et nous nous sommes également intéressés aux polymères de coordination d'or (I), un intermédiaire de réaction important dans la synthèse de clusters et à ses propriétés photophysiques. Afin d'avoir des clusters avec une fonction externe permettant de les assembler ou de les déposer sur un support, nous avons développé une nouvelle voie de synthèse de clusters stabilisés par des ligands de type thiophénolates para-substitués. Nous avons ainsi isolé de nouveaux clusters stabilisés par des ligands hétérotopiques comme [Au25(SPh-pNH2)17]. Ces composés ont ensuite été déposés sur un support mésoporeux (SBA-15) et utilisés comme catalyseurs dans différentes réactions d'oxydation. Nos résultats montrent que les clusters d'or sont donc des précurseurs moléculaires permettant de préparer des catalyseurs efficaces, ayant une petite taille de particules (1-2 nm) et présentant des activités catalytiques très élevées comparativement aux matériaux de référenceSmall gold nanoparticles (< 5 nm) are materials presenting a good catalytic activity in oxidations reactions, especially under soft conditions of temperature and pressure. However, it can be difficult to obtain monodisperse particles with a diameter less than 5 nm. In this sense, gold clusters are interesting, because they are atomically defined compounds, presenting a proper formulation. This means that the number of gold atoms and of stabilizers in the clusters are defined and, as they can be isolated pure, they constitue a novel class of perfectly monodisperse nanomaterials. Therefore, we are interested, in this thesis, in the synthesis and assembly of gold clusters. Indeed, gold nanoparticles are usually deposited on a support, resulting in the loss of accessible area. We therefore wanted to use gold clusters as (i) molecular species deposited on a support and (ii) as building blocks to assemble and organize tridimensional networks where the porosity permits the substrates/products diffusions and avoid the support effects. Our study deals with the synthesis of gold clusters, and we are also interested in the gold (I) coordination polymers, which are important reaction intermediates formed during the clusters synthesis and to its photophysical properties. In order to have clusters presenting external functions enabling their assembly or deposition on a support, we developed a novel synthesis suitable for para-substituted thiophenolates. We managed to isolate new clusters stabilized by heterotopic ligands such as [Au25(SPh-pNH2)17]. Those compounds have been deposited on a mesoporous support and used as oxidative catalysts. Our results show that gold clusters are molecular precursors that permit to prepare effective catalysts with narrow particle size (1-2 nm) and presenting high catalytic activity compared to the one exhibited by reference materials
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Haiduke, Ivonete Ferreira. "Inclusão de acadêmicos com necessidades especiais na universidade : a influência do GT-AUNE no acesso ao ensino e aprendizagem / Ivonete Ferreira Haiduke ; orientador Paulo R. Alcântara." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2006. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=541.
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Dissertação (mestrado) - Pontifícia Universidade Católica do Paraná, Curitiba, 2006Inclui bibliografia
A dissertação aborda o tema "o Processo de Inserção do Estudante Acadêmico Especial na Universidade", de forma a investigar alternativas para melhorar o processo de inclusão acadêmica nas universidades. Verificando a existência de um grupo de professores
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Mendes, Niege Silva. "Análise global do perfil transcricional e splicing alternativo no dermatófito Trichophyton rubrum exposto à doses subinibitórias de ácido undecanóico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-04012017-104024/.
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O dermatófito Trichophyton rubrum é um fungo filamentoso, antropofílico, que invade tecidos queratinizados causando infecções superficiais e cutâneas. Algumas drogas são usadas para o tratamento das dermatofitoses, sendo o ácido undecanóico (AUN) uma delas. O AUN é o mais tóxico dos ácidos graxos saturados de cadeia média, utilizado como medicamento de uso tópico. O estudo de expressão gênica e mecanismos regulatórios são fundamentais para ampliar o conhecimento dos mecanismos moleculares envolvidos na resposta à exposição a estes agentes citotóxicos. Portanto, o objetivo deste trabalho foi caracterizar os mecanismos moleculares envolvidos no processo adaptativo da exposição ao ácido undecanóico, através da análise global do transcriptoma e mecanismos regulatórios como o processamento alternativo. Para tanto o micélio de T.rubrum foi submetido ao ácido undecanóico por 3 e 12 h de exposição, em triplicata biológica, e o RNA resultante foi submetido ao sequenciamento por RNAseq. O sequenciamento gerou aproximadamente 58 milhões de reads por biblioteca, as quais foram filtradas e alinhadas com o genoma de referência utilizando-se os softwares FASTQC e bowtie2, respectivamente. A análise de expressão gênica diferencial foi feita por meio do pacote do Bioconductor DESeq e, para esta análise, foi utilizada a amostra de 0h como referência. Foram identificados 492 genes diferencialmente expressos em resposta ao AUN, sendo 385 e 210 genes modulados em resposta a 3 e 12 horas de exposição, respectivamente. Estes genes estão relacionados a vários processos celulares envolvendo transporte transmembrana, degradação de xenobióticos, metabolismo de lipídeos e aminoácidos, secreção de enzimas proteolíticas e patogênese, sugerindo que o AUN ativa duas principais vias de sobrevivência em resposta a este agente estressor, a degradação e o efluxo da droga. Posteriormente, foram realizadas as análises de processamento alternativo quanto ao uso diferencial de exons por meio do algoritmo HTSeq e DEXSeq e retenção de introns utilizando-se algoritmos construídos na linguagem Perl. Os genes envolvidos em algum tipo de processamento alternativo estão relacionados com funções metabólicas variadas como tradução, transporte vesicular, metabolismo lipídico, biogênese ribossomal, sequência de ligação ao DNA, regulação da transcrição e processamento do pré-mRNA. Estes resultados contribuem para uma melhor compreensão dos mecanismos moleculares envolvidos na resposta de sobrevivência perante a exposição ao AUN.The dermatophyte Trichophyton rubrum is a filamentous fungus, anthropophilic that invades keratinized tissue causing superficial infections on the skin. Some drugs are used for the treatment of dermatophytosis, being the undecanoic acid (AUN) one of them. The AUN the most toxic of the saturated medium chain fatty acids, is used as a topical medicine. The study of gene expression and the regulatory mechanisms are fundamental to understand the molecular mechanisms involved in response to exposure of these cytotoxic agents. So, the aim of this study was to characterize the molecular mechanisms involved in the adaptive process of the exposure to undecanoic acid, by the global analysis of the transcriptome and regulatory mechanisms such as alternative splicing. To this end, the mycelium of T. rubrum was exposed to undecanoic acid for 3 or 12 hours in biological triplicate, and the resulting RNA was sequenced by RNA-Seq. The sequencing generated approximately 58 million of reads per library, which were filtered and aligned with the reference genome using the softwares and Bowtie2 and FASTQC, respectively. The analysis of differential gene expression was performed through the Bioconductor package DESeq and, for this analysis, we used as reference sample the 0h time. We identified 492 differentially expressed genes in response to UDA, being 385 and 210 genes modulated in response to 3 and 12 hours of exposure, respectively. These genes are related to various cellular processes involving the transmembrane transport, xenobiotics degradation, lipids and amino acids metabolism, secretion of proteolytic enzymes and pathogenesis, suggesting the activation of two major survival pathways in response to this stressor, degradation and drug efflux, by UDA. Also, the alternative splicing analysis was performed through the differential use of exons using the algorithms HTSeq and DEXSeq and intron retention using algorithms built in Perl language. The genes involved in some kind of alternative splicing are associated with various metabolic functions such as translation, vesicular transport, lipid metabolism, ribosomal biogenesis, DNA binding sequence, transcription regulation and processing of pre-mRNA. These results contribute to increase the knowledge of the molecular mechanisms involved in the survival response upon exposure to the AUN.
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García, Mayo Susana. "Synthesis of gold nanoparticles for rapid genotyping of M. tuberculosis using rolling circle amplification and nanoflare technology." Thesis, Stockholms universitet, Avdelningen för materialkemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191049.
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Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis, with an incidence in a quarter of the world population. Despite the scientific and technological advances, an effective diagnostic method has not yet been found that allows an early diagnosis and, also, to detect the strain present in the patient. The combination of nanotechnology with molecular diagnostics has shown promising advances offering new possibilities, such as the development of nanoflares. Nanoflares represent a new class of molecular probes, composed of gold nanoparticles functionalized with a recognition sequence that can be amplified by rolling circle amplification (RCA) technique, producing a fluorescence signal. This thesis focuses in the synthesis of gold nanoparticles, with different coatings and sizes, as well as their subsequent application in the preparation and optimization of nanoflares for the genotyping of synthetic M. tuberculosis targets using RCA technique. The different preparations of nanoflares have an impact in the assay sensitivity, showing two times increase in sensitivity for citrate-coated nanoparticles with respect to those coated with PEG. Furthermore, it was observed that the sensitivity is directly related to the synthesized particle size. Sensitivity is also affected by the application of a purification post-treatment of the synthesis product. This post-treatment reduces the sensitivity of nanoflares by up to 37% but, by contrast, extends its useful life. The results obtained are shown as a proof of concept for a future cost-effective, rapid and robust in situ diagnostic method that identifies the strain of tuberculosis present in the patient.
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Fritz, Fuentes Consuelo Zenaida. "Rendimiento de azúcares reductores a partir de Nothofagus pumilio (Poepp. et Endl.) Krasser sometido aun pretratamiento biológico para la producción de etanol." Tesis, Universidad de Chile, 2009. http://repositorio.uchile.cl/handle/2250/151540.
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Memoria para optar al Título Profesional de Ingeniera de la MaderaLos bosques de lenga, Nothofagus pumilio (Poepp. et Endl.) Krasser, en general, son considerados sobremaduros, debido a la gran cantidad de árboles en fase de desmoronamiento y envejecimiento, obteniéndose rendimientos bajos en los procesos de industrialización. Los residuos representan una importante y posible fuente de biomasa para la generación de biocombustibles. Los residuos de lenga obtenidos de la empresa Forestal Rusffin, que corresponden a desechos provenientes del proceso de manufactura, fueron sometidos a un pretratamiento biológico con tres hongos de pudrición blanca (HPB), Stereum hirsutum, Ganoderma applanatum y Aurantioporus albidus y durante tres tiempos de ataque: 30, 45 y 60 días. Las partículas de madera se adecuaron a un tamaño denominado “pin-chips”, con dimensiones aproximadas de 1 mm de espesor, 1 a 3 mm de ancho y 5 mm de largo, posteriormente fueron sometidos a la acción fúngica. Las cepas se incubaron previamente en granos de trigo y luego fueron inoculadas en los “pin-chips” de lenga, permaneciendo en una cámara de incubación a 25º C según los tres tiempos de ataque.
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Nguyen, Tan Dai. "Les TIC au service de la qualité des formations : le cas des programmes vietnamiens évalués par l'ASEAN University Network." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAG004/document.
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Depuis plus d'une vingtaine d'années, la qualité de l'éducation au Vietnam est souvent remise en cause et le système éducatif fait l'objet de plusieurs débats et initiatives de rénovation, sans pour autant atteindre les résultats attendus. Innover par le numérique et intégration internationale figurent parmi les priorités fixées dans la politique nationale, notamment au niveau d’enseignement supérieur. Beaucoup de programmes d’enseignement supérieur au Vietnam ont été évalués par l'ASEAN University Network (AUN). Parmi de nombreux critères de cette démarche d'évaluation, 15 sous-critères concernent de près ou de loin l'usage des TIC dans les formations. L’analyse des résultats de quatre programmes vietnamiens évalués en 2009 et 2011 montre qu'il existe une différence dans la perception réelle des sous-critères liés aux TIC entre les parties prenantes internes et les évaluateurs externes de ces programmes. À partir de ce constat, nous élaborons un instrument de mesure susceptible de permettre à tous les acteurs internes et externes d’un programme de formation d’identifier ce qui contribue à la satisfaction des étudiants vis-à-vis de l’usage des TIC dans les cours dispensés. Différents modèles existants (TAM, CEQ, SCEQ, eLEQ) ont été intégrés et adaptés dans le contexte de l’évaluation des programmes par l’AUN. Des enquêtes ont été menées auprès de plusieurs centaines d’étudiants de cinq programmes évalués en 2009, 2011 et 2014. Les résultats permettent de confirmer la validité et l’ajustement du modèle que nous proposonsSince more than twenty years, the educational quality has been subject to lots of public debates in Vietnam. Several renovation solutions was adopted without achieving the expected results. As the country has strongly integrated the international market, ICT-based innovation and international quality assessment become first priorities fixed in the national educational policies. A lot of training programmes have been assessed by the ASEAN University Network (AUN). Among the criteria used in this quality-assurance assessment, encompassing 15 sub-criteria that relate more or less to the use of the ICT in the educational activities. We analyzed the results of four Vietnamese programmes assessed in 2009 and 2011 and founded that there is a significant difference of the perception about the ICT use quality between the internal stakeholders and the external assessors in these programmes. From this revelation, we aim to elaborate a measurement instrument which may help all of the programme’s internal or external stakeholders to identify the factors contributing to the students’ satisfaction about the ICT use in their degree courses. Some existing models such as TAM, CEQ, SCEQ, eLEQ were integrated in the context of AUN-QA assessment at the programme level. The survey was conducted at five Vietnamese programmes assessed in 2009, 2011 and 2014, with 453 full responses. The data analysis confirms the validity of our proposed measurement model
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Canova, André Luiz Fassone [UNESP]. "Estudo químico quântico relativístico das propriedades eletrônicas e estruturais dos compostos Aun(n=1-5), AuOn-e AuSn - (n=1-2) e AuH." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/116003.
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000808608.pdf: 1523686 bytes, checksum: f545c7465c56b46cea6da94906c9f8a7 (MD5)Os efeitos relativístico estão mais próximos de nós do que pensamos, com por exemplo: na cor do metal Ouro, no funcionamento da bateria Chumbo-ácido entre outros. Os efeitos relativísticos são mais intensos em átomos pesados, sobretudo no átomo de Ouro, desempenhando um papel essencial para a interpretação dos fenômenos de natureza quântica, visto que os seus efeitos tendem a alterar significativamente a energia e a geometria dos sistemas. Quando comparados aos resultados obtidos pela utilização de metodologias não relativísticas (HF) e quasi relativística (ZORA) podemos perceber claramente a influência das consequências da Teoria da Relatividade, como por exemplo: o acoplamento spin-órbita e a quebra da degenerescência na enrgia dos orbitais. Nesse trabalho, iremos utilizar as metodologias relativísticas de Dirac-Hartree-Fock (DHF) e Teoria do Funcional de Densidade (DFT) para o estudo de sistemas compostos por átomos de Ouro e demonstraremos que, apesar do elevado custo computacional envolvido, as metodologias relativísticas devem ser a primeira opção de escolha dada a excelente qualidade dos resultados obtidos, em propriedades geométricas eletrônicas, tais como: a distância de ligação e Afinidade Eletrônica. Particularmente no estudo da molécula de Au2 obtivemos excelente resultado para a distância de ligação, pois a divergência entre o valor teórico (utilizando-se dessas metodologias) e o valor experimental é de apenas 4,05%
Relativistic effects are clorer to up than we think, such as: gold color metal, the operation of lead-acid battery among others. Relativistic effects are more intense in heavy atoms, especially of gold atom, having an essential role for the interpretation of the phenomena of quantum nature, since their effects tend to significantly change the energy and the geometry of the systems. When compared to results obtained by using non-relativistic methods (HF) and quasi-relativistic (ZORA) we can clearly see the influence of the consequences of the theory of relativity, for example, the spinorbit coupling and the breaking of degenerte orbitals. In this work, we will use the relativistic Dirac-Hartree methodologies-Fock (DHF) and Density Functional Theory (DFT) to study systems composed of gold atoms and demonstrate that, despite the high computational cost involved, the relativistic methodologies should be the first option of choise due to excellent quality of the results obtained in geometric and electronic properties such as the bond distance and Electron Afinity. Particularly in the study of molecule Au2 excellent result obtained for the connection distance as the divergence between the theoretical valeu (using these methodologies) and the experimental value is only 4.05%
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Canova, André Luiz Fassone. "Estudo químico quântico relativístico das propriedades eletrônicas e estruturais dos compostos Aun(n=1-5), AuOn-e AuSn - (n=1-2) e AuH /." Bauru, 2014. http://hdl.handle.net/11449/116003.
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Orientador: Aguinaldo Robinson de SouzaBanca: Nelson Henrique Morgon
Banca: Alberico Borges Ferreira da Silva
Banca: Fernando Luis Barroso da Silva
Banca: Alexys Bruno Alfonso
Resumo: Os efeitos relativístico estão mais próximos de nós do que pensamos, com por exemplo: na cor do metal Ouro, no funcionamento da bateria Chumbo-ácido entre outros. Os efeitos relativísticos são mais intensos em átomos pesados, sobretudo no átomo de Ouro, desempenhando um papel essencial para a interpretação dos fenômenos de natureza quântica, visto que os seus efeitos tendem a alterar significativamente a energia e a geometria dos sistemas. Quando comparados aos resultados obtidos pela utilização de metodologias não relativísticas (HF) e quasi relativística (ZORA) podemos perceber claramente a influência das consequências da Teoria da Relatividade, como por exemplo: o acoplamento spin-órbita e a quebra da degenerescência na enrgia dos orbitais. Nesse trabalho, iremos utilizar as metodologias relativísticas de Dirac-Hartree-Fock (DHF) e Teoria do Funcional de Densidade (DFT) para o estudo de sistemas compostos por átomos de Ouro e demonstraremos que, apesar do elevado custo computacional envolvido, as metodologias relativísticas devem ser a primeira opção de escolha dada a excelente qualidade dos resultados obtidos, em propriedades geométricas eletrônicas, tais como: a distância de ligação e Afinidade Eletrônica. Particularmente no estudo da molécula de Au2 obtivemos excelente resultado para a distância de ligação, pois a divergência entre o valor teórico (utilizando-se dessas metodologias) e o valor experimental é de apenas 4,05%
Abstract: Relativistic effects are clorer to up than we think, such as: gold color metal, the operation of lead-acid battery among others. Relativistic effects are more intense in heavy atoms, especially of gold atom, having an essential role for the interpretation of the phenomena of quantum nature, since their effects tend to significantly change the energy and the geometry of the systems. When compared to results obtained by using non-relativistic methods (HF) and quasi-relativistic (ZORA) we can clearly see the influence of the consequences of the theory of relativity, for example, the spinorbit coupling and the breaking of degenerte orbitals. In this work, we will use the relativistic Dirac-Hartree methodologies-Fock (DHF) and Density Functional Theory (DFT) to study systems composed of gold atoms and demonstrate that, despite the high computational cost involved, the relativistic methodologies should be the first option of choise due to excellent quality of the results obtained in geometric and electronic properties such as the bond distance and Electron Afinity. Particularly in the study of molecule Au2 excellent result obtained for the connection distance as the divergence between the theoretical valeu (using these methodologies) and the experimental value is only 4.05%
Doutor
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Pacaud, Mathias. "Synthesis and physico-chemical evaluation of gold nanoflowers (AuNFs) as new substrates for bioanalytical SERS." Thesis, Tours, 2019. http://www.theses.fr/2019TOUR3804.
Full textAbstract:
Un immense intérêt est porté sur les nanostructures métalliques anisotropes d’or (AuNFs) qui s’explique par les propriétés uniques qu’elles procurent et qui peuvent servir dans divers domaines, notamment dans le biomédicale. On cherche à maitriser leurs propriétés optiques liées aux oscillations collectives d’électrons de surface appelées plasmons. Elles possèdent une bande de résonance plasmonique localisée de surface (LSPR, comme localized surface plasmon resonance) située dans le rouge - proche infrarouge (> 600 nm). Leur capacité d’interagir avec la lumière rouge - proche IR (fenêtre optique biologique) les rend intéressantes en tant qu’agent d’imagerie optique et opto-acoustique. Dans le cas particulier de la diffusion Raman exaltée de surface (SERS, comme surface-enhanced Raman scattering), les AuNFs sont capables de procurer les zones d’exaltation appelées « hot spots » dans les jonctions entre leurs pétales. Ainsi, on peut les utiliser comme substrat SERS sans avoir besoin de les agréger, à la différence des nanosphères d’or. Le protocole de synthèse des AuNFs que nous avons développé est rapide, en une seule étape et n’utilise qu’un nombre réduit de réactifs connus qui sont peu ou pas toxiques. De plus, notre protocole permet de contrôler les caractéristiques des AuNFs telles que leur taille et la position de leur bande LSPR, entre 600 et 900 nm. Afin de garantir une stabilité colloïdale dans des milieux divers, nous avons enrobé nos AuNFs avec des polymères biocompatibles (alginates, chitosan, Pluronics, PVP et PEG) ou les avons encapsulées dans une matrice de silice. Les substrats colloïdaux à base de ces AuNFs enrobées d’enveloppes biocompatibles ont ainsi montré leur potentiel pour procurer l’effet SERS sans agrégation et permettre l’analyse ultrasensible de petits chromophores (comme le Bleu de Nil). De plus, nos résultats montrent que ces nouveaux substrats sont capables de délivrer une charge de molécules dans des cellules cancéreuses. Ainsi, ils semblent prometteurs en tant qu’agents théranostiques, applicables non seulement en SERS, mais également en imagerie optique ou opto-acoustique et en thérapieA huge attention is paid on anisotropic gold metal nanostructures (AuNFs) because of the unique properties they can provide in various fields, in particular the biomedical applications. We are trying to control their optical properties related to the collective oscillations of surface electrons called plasmons. They have a localized surface plasmon resonance band (LSPR) located in the red - near infrared (> 600 nm). Their ability to interact with red light - near IR (optical biological window) makes them interesting as optical and optoacoustic imaging agents. In the specific case of the surface-enhanced Raman scattering (SERS), AuNFs are able to provide enhancement zones called "hot spots" in the junctions between their petals. Thus, they can be used as SERS substrates without the need to be aggregated, unlike for gold nanospheres. The protocol to synthesize AuNFs that we developed is fast, in one-step and uses only a small number of known reagents that are low or non-toxic. In addition, our protocol allows us to tune the characteristics of the AuNFs such as their size and the position of their LSPR band, between 600 and 900 nm. In order to guarantee their colloidal stability in various media, we have coated our AuNFs with biocompatible polymers (alginates, chitosan, Pluronics, PVP and PEG) or encapsulated them in a silica matrix. Colloidal substrates based on these AuNFs coated with biocompatible envelopes have thus shown their potential to provide the SERS effect without aggregation and allow the ultra-sensitive analysis of small chromophores (such as Nile Blue). In addition, our results show that these new substrates are able to deliver a cargo of molecules to the cancer cells. Thus, they seem promising as theranostic agents, applicable not only in SERS, but also in optical or optoacoustic imaging and therapy
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Aung, Pyi Soe [Verfasser], Jürgen [Gutachter] Pretzsch, Goddert von [Gutachter] Oheimb, and Eivin [Gutachter] Røskaft. "Social-Ecological Coevolution and its Implications for Protected Area Management: Case Study in Natma Taung National Park, Myanmar / Pyi Soe Aung ; Gutachter: Jürgen Pretzsch, Goddert von Oheimb, Eivin Røskaft." Dresden : Technische Universität Dresden, 2020. http://d-nb.info/1227196881/34.
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Nunez, Chanda. "Just like Ole' Mammy used to Make: Reinterpreting New Orleans African-American Praline Vendors as Entrepreneurs." ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/128.
Full textAbstract:
Women commonly sold goods on the streets of New Orleans throughout the city‘s colonial and antebellum history. Forming a significant presence among the city‘s market places, they sold various food items which included coffee, calas, and pralines. Perhaps the most popular of the African-American street vendors was the praline women. They attracted the attention of visitors as well as residents. Despite the popularity of these treats, the highly visible and enterprising praline vendors were simultaneously celebrated and caricatured by white observers who depicted them as mammy figures not only in store advertisements and logos, but also in everyday annotations.
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Snyder, Tara. "NOT QUITE THE INGéNUE: THE DEVELOPMENT OF THE MIDDLE-AGED FEMALE CHARACTER IN MUSICAL THEATRE." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4085.
Full textAbstract:
Not Quite the Ingénue: The Development of the Middle-Aged Female Character in Musical Theatre is an exploration of the influences which have defined the function of middle-aged female characters within the musical theatre genre. This author was cast in the role of Arlene MacNalley, a forty-three year old woman, in the University of Central Florida's fall 2006 production of the musical Baby. Preparation for performance of this thesis role required identification of the traits and factors which would be vital for a realistic and relevant portrayal of Arlene. This document provides the reader with a working definition of middle age. It also furnishes a sampling of types, or stereotypes, of middle age female characters in musicals. The major thrust of the document emphasizes researching and understanding the importance of key socio-economic events' influence on the creation, direction, or depiction of middle-aged female characters. Three distinct characters are used to develop this theory, Aunt Eller in Oklahoma!, Dolly Levi in Hello, Dolly! and Arlene MacNalley in Baby. Further analysis within the thesis details essential differences between the original version of Arlene and the updated 2006 version of Arlene portrayed in the University of Central Florida's production of Baby. Conclusions drawn from the research, performance and writing processes indicate an increasing significance for the middle age female character as the genre of musical theatre continues to develop.M.F.A.
Department of Theatre
Arts and Humanities
Theatre MFA