Academic literature on the topic 'Atropisomerismo'
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Journal articles on the topic "Atropisomerismo"
Clayden, Jonathan. "Atropisomerism." Tetrahedron 60, no. 20 (May 2004): 4335. http://dx.doi.org/10.1016/j.tet.2004.03.002.
Full textCzarnocki, Zbigniew, and Piotr Pomarański. "Arylpyridines: A Review from Selective Synthesis to Atropisomerism." Synthesis 51, no. 03 (December 14, 2018): 587–611. http://dx.doi.org/10.1055/s-0037-1611365.
Full textSiegel, Jay. "Prologue: Atropisomerism." Synlett 29, no. 16 (September 21, 2018): 2122–25. http://dx.doi.org/10.1055/s-0037-1610908.
Full textFordyce, Euan A. F., S. Fraser Hunt, Damien Crepin, Stuart T. Onions, Guillaume F. Parra, Chris J. Sleigh, John King-Underwood, Harry Finch, and John Murray. "Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities." MedChemComm 9, no. 3 (2018): 583–89. http://dx.doi.org/10.1039/c8md00033f.
Full textBirepinte, Mélodie, Frédéric Robert, Sandra Pinet, Laurent Chabaud, and Mathieu Pucheault. "Non-biaryl atropisomerism at the C–B bond in sterically hindered aminoarylboranes." Organic & Biomolecular Chemistry 18, no. 16 (2020): 3007–11. http://dx.doi.org/10.1039/d0ob00421a.
Full textBischetti, Martina, Giuseppe Pomarico, Sara Nardis, Federica Mandoj, Daniel O. Cicero, and Roberto Paolesse. "5,10,15-Triarylcorrole atropisomerism." Journal of Porphyrins and Phthalocyanines 24, no. 01n03 (January 2020): 153–60. http://dx.doi.org/10.1142/s1088424619500706.
Full textSiegel, Jay. "Cluster Preface: Atropisomerism." Synlett 29, no. 16 (September 21, 2018): 2120–21. http://dx.doi.org/10.1055/s-0037-1610998.
Full textBoiadjiev, Stefan E., and David A. Lightner. "Atropisomerism in monopyrroles." Tetrahedron: Asymmetry 13, no. 16 (August 2002): 1721–32. http://dx.doi.org/10.1016/s0957-4166(02)00481-0.
Full textCiogli, A., S. Vivek Kumar, M. Mancinelli, A. Mazzanti, S. Perumal, C. Severi, and C. Villani. "Atropisomerism in 3-arylthiazolidine-2-thiones. A combined dynamic NMR and dynamic HPLC study." Organic & Biomolecular Chemistry 14, no. 47 (2016): 11137–47. http://dx.doi.org/10.1039/c6ob02145j.
Full textKöster, Roland, Günther Seidel, Susanna Kerschl, and Bernd Wrackmeyer. "Atropisomerism in Boron-Nitrogen Heterocycles/Atropisomerism in Boron-Nitrogen Heterocycles." Zeitschrift für Naturforschung B 42, no. 2 (February 1, 1987): 191–94. http://dx.doi.org/10.1515/znb-1987-0212.
Full textDissertations / Theses on the topic "Atropisomerismo"
Fontanive, Luca. "Nanoscale intercation for higher efficiency of contrast media." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/4476.
Full textIopamidolo, Iomeprolo e Iopromide sono Mezzi di Contrasto Iodinati Non-ionici (MCIN) usati in urografia e angiografia come soluzioni concentrate. I dati relativi ai MCIN presenti in letteratura mostrano un’abbondanza di informazioni cliniche ma una carenza di dati riguardanti le loro caratteristiche chimico-fisiche. L’efficenza di questi composti in ambito medico è dovuta alla combinazione di tali proprietà. Risulta quindi necessario uno studio relativo ai dettagli molecolari per chiarire i contributi di ogni gruppo funzionale del sistema che determinano le differenze in termini di comportamento chimico-fisico. Le soluzioni concentrate di MCIN sono caratterizzate da bassi valori di viscosità e osmolalità dovuti all’autoassemblamento del sistema che genera aggregati nanostrutturati solubili in soluzione acquosa. Da queste considerazioni, questo lavoro di ricerca si è focalizzata su tecniche spettroscopiche, termodinamiche e di simulazioni di dinamica molecolare per indagare il fenomeno dell’associazione, sia in funzione della temperatura che della concentrazione, relazionato alle interazioni intermolecolari che spesso sono la principale causa della stabilità delle soluzioni concentrate di MCIN. Questi composti possiedono una struttura molecolare relativamente semplice, ma sono sistemi complessi in quanto soggetti all’atropisomerismo che causa la coesistenza di isomeri strutturali (atropisomeri) in soluzione, quindi di diverse geometrie di interazione soluto-soluto. Il primo approccio sperimentale è stata la caratterizazione molecolare attraverso la spettroscopia NMR per determinare gli equilibri conformazionali in termini di percentuali di popolazione in soluzione. Studi termodinamici hanno permesso di classificare Iopamidolo, Iomeprolo e Iopromide in base alle loro caratteristiche idrofiliche ed idrofobiche nei confronti delle molecole di acqua. Parallelamente sono state realizzate simulazioni di dinamica molecolare per ottenere informazioni riguardo la sfera di idratazione (confrontate con i dati termodinamici da letteratura) e sul processo di associazione che è stato studiato in funzione della temperatura sia con la spettroscopia NMR che con quella Brillouin. Ulteriori informazioni sulle interazioni intermolecolari e sull’atropisomerismo sono state ottenute analizzando anche lo stato solido dello Iopamidolo e dello Iomeprolo (sia sui vetri che sui cristalli) tramite tecniche spettroscopiche, calorimetriche e diffrattometriche i cui risultati hanno mostrato analogie in termini di interazioni intermolecolari fra le catene laterali. Inoltre, studi in funzione della temperatura hanno mostrato alcune transizioni solido-solido. L’accumulo di dati sperimentali relativi alla calorimetria isoterma e a scansione, traiettorie di dinamica molecolare ed alle varie spettroscopie, ha permesso di estendere il quadro generale delle conoscenze delle proprietà chimico-fisiche dei MCIN.
Iopamidol, Iomeprol and Iopromide are Non-ionic Iodinated Contrast Media (NICMs) are used as concentrated solutions in x-Ray diagnostics as angiography and urography. The analysis of the current literature knowledge on NICMs shows an clear abundance of clinical diagnosis data but a lack of information on their physico-chemical properties. The success of these molecules in diagnosis is due to a combination of their properties, but a clarification of the role of structural determinants affecting the processes in concentrated solution is necessary. Thus a study of the molecular details may shed light on the differences in physico-chemical behavior. The concentrated solutions of NICMs are characterize by low viscosity and osmolality values due to the self-assembling of the system that generates soluble nano-structured aggregates in aqueous solution. Standing these considerations, the research work focused on spectroscopic, thermodynamics and MD simulation techniques to probe the association phenomenon, as a function of concentration and temperature. The interplay of the intermolecular interactions are the main reason for the stability of the concentrated solution of NICMs. Non-ionic iodinated contrast media have quite a simple molecular structure, but they show a complex behaviour due to the atropisomerism phenomenon. The coexistence of several structural isomers (atropisomers) in solution is at the basis of the different geometries of solute-solute interasctions. Thus, the first study whas been the molecular characterization of these molecules by using NMR spectroscopy to probe the conformational equilibria in terms of conformer population in solution. Thermodynamic approaches provided a classification of Iopamidol, Iomeprol and Iopromide according to their thermodynamics behaviour in terms of hydrophilic and hydrophobic interactions with water molecules. In parallel, MD simulations data were carried out to provide information about hydration shell (which were compared with experimental data from literature) and aggregation process. Similarly, the association was probed by both NMR and experimental thermodynamic data. To have more information on the nature of intermolecular interactions and atropisomerism phenomenon the solids of Iomeprol and Iopamidol (either or glasses and crystals) were analyzed by spectroscopic, calorimetric and diffractometric techniques that shown agreement in terms of intermolecular interactions among side chains. Furthemore, solid-solid transitions were detected as a function of temperature. By collecting experimental data by isothermal and scanning calorimetry, thermodynamic properties, molecular dynamics simulations and expecially by several spectroscopics methods a choerent description of the structure and dynamics of NICMs has been achieved. These results provide new knowledge on thier physico-chemical properties and allow us to interpret some anclear phenomena.
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Yau, Chi. "Atropisomerism and the synthesis of lignans." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62875.pdf.
Full textSenior, James Daniel. "Atropisomerism in biaryl sulfides and sulfones." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498670.
Full textWilson, Paul. "Reducing catalyst loadings in radical cyclisation reactions and investigating atropisomerism in enamides." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/34645/.
Full textArmstrong, Roland. "Catalytic asymmetric reactions employing chiral cations." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:6f38eb98-32ff-4b06-b144-100480da87dd.
Full textPerticarari, Sofia. "Atropisomeric xanthines: Synthesis, stereodynamics and absolute configuration." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9025/.
Full textBirepinte, Mélodie. "Amino(organo)boranes, synthèse et propriétés." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0231.
Full textThis manuscript presents the synthesis, reactivity and properties of amino(organo)boranes. The diisopropylaminoborane has been used for the formation of carbon-boron bonds. Its reactivity as a borylating agent was first explored for the hydroboration of alkynes catalyzed by Schwartz reageant. A large variety of alkenylaminoboranes, -boronates and -diazaborolanes was thus synthesized. Their stereoselective transformation into E and Z bromoalkenes was also optimized. The borylation of terminal alkynes via a tandem process of dehydrogenation/ dehydrogenative coupling allowed the access to a large scope of alkynylaminoboranes. Finally, the different reactivities of aminoboranes were used for the preparation of borinic acids bearing a phosphine group but also of a new class of chiral boron derivatives via a C-B atropisomerism. These chiral aminoarylboranes were fully characterized after separating the enantiomers and running spectroscopic analyses and racemization studies
Augros, David. "Synthèses de biaryles atropoenrichis et de biphénylènes via des arynes substitués." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF040/document.
Full textThis work consisted in the study of the “aryne coupling”, a transition-metal free process to access biaryl moieties, which involves the reaction between two in situ generated intermediates: a nucleophilic aryllithium derivative and an electrophilic aryne. This work resided in the optimization of the atropoenantioselective version of the aryne coupling and its application to the formal synthesis of (-)-steganacin. We then moved to the atropoenantioselective version of the reaction, by introducing chiral ligands in the reaction mixture, which aim was to coordinate the aryllithium species and to transfer their chiral information to the biaryl axis. After optimization of various reaction parameters, some enantiomeric excesses were obtained as well as various side products in some cases, among which biphenylene derivatives. According to the potential applications of these compounds, another part of this work was dedicated to their synthesis by means of aryne dimerization reactions
Böhnisch, Torben. "C2-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal Catalysis." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-876A-6.
Full textRebouças, Júlio Santos. "Exploring and exploiting Ruthenium-porphyrin complexes : functionalization, atropisomerism, small-molecule recognition, catalysis, and biological implications." Thesis, 2006. http://hdl.handle.net/2429/18618.
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Books on the topic "Atropisomerismo"
Westlund, Neil Edward. Atropisomerism in hindered tertiary amides. Manchester: University of Manchester, 1996.
Find full textLassaletta, José M. Atropisomerism and Axial Chirality. WORLD SCIENTIFIC (EUROPE), 2018. http://dx.doi.org/10.1142/q0192.
Full textBook chapters on the topic "Atropisomerismo"
Ōki, Michinori. "Recent Advances in Atropisomerism." In Topics in Stereochemistry, 1–81. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470147238.ch1.
Full textCesàro, Attilio, Barbara Bellich, Giovanna Giannini, and Alessandro Maiocchi. "Conformational Disorder and Atropisomerism in Pharmaceutical Compounds." In Disordered Pharmaceutical Materials, 161–82. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527652693.ch6.
Full textDreikorn, Barry A., Glen P. Jourdan, and Harold R. Hall. "Influence of Atropisomerism on the Fungicidal Activity of a Series of Thioalkylphenylalanines." In ACS Symposium Series, 575–88. Washington, DC: American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0443.ch046.
Full textJoshi, Gaurav, Manpreet Kaur, and Raj Kumar. "Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges." In Drug Discovery and Development, 103–24. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-5534-3_4.
Full textRos, Abel, Pedro Ramírez-López, Rosario Fernández, and José María Lassaletta. "Asymmetric Synthesis of Axially Chiral Biaryls and Heterobiaryls." In Atropisomerism and Axial Chirality, 1–97. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0001.
Full textKondoh, Azusa, and Masahiro Terada. "Applications of Axially Chiral Organocatalysts." In Atropisomerism and Axial Chirality, 99–147. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0002.
Full textYurino, Taiga, and Takeshi Ohkuma. "Axially Chiral P,P-Ligands for Asymmetric Metal-Catalyzed Reactions." In Atropisomerism and Axial Chirality, 149–247. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0003.
Full textGualtierotti, Jean-Baptiste, Valentín Hornillos, and Ben L. Feringa. "Axially Chiral Monodentate Phosphorus Ligands for Asymmetric Metal-Catalyzed Reactions." In Atropisomerism and Axial Chirality, 249–377. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0004.
Full textRokade, Balaji V., and Patrick J. Guiry. "Axially Chiral P,X-Ligands (X = N, O, and S) for Asymmetric Metal-Catalyzed Reactions." In Atropisomerism and Axial Chirality, 379–445. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0005.
Full textYing, Jun, and Lin Pu. "Axially Chiral X,X-Ligands (X = N, O) for Asymmetric Metal-Catalyzed Reactions." In Atropisomerism and Axial Chirality, 447–88. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0006.
Full textConference papers on the topic "Atropisomerismo"
Cardoso, Flávio Sêga Pereira, and Aaron Aponick. "A New Approach to Atropisomerism." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013816154041.
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