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Dissertations / Theses on the topic 'Atriale fibrosis'

Author: Grafiati

Published: 11 March 2023

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1

Guichard, Jean-Baptiste. "Déterminants du remodelage atrial et de son effet pro-arythmique dans la fibrillation atriale." Thesis, Lyon, 2019. http://hdl.handle.net/1866/24623.

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Rationnel et objectif - La fibrillation atriale (FA) est la pathologie rythmique supra-ventriculaire la plus fréquemment diagnostiquée. Le remodelage atrial, qu’il soit électrique ou structurel, conduit à la mise en place et au développement de la cardiomyopathie atriale. La cardiomyopathie atriale est responsable de différentes complications : d’une part mécaniques conduisant à l’augmentation du risque thrombo-embolique et de l’insuffisance cardiaque, d’autre part électriques conduisant à différentes arythmies atriales dont la FA. L’objectif du présent travail est de caractériser les détermin

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2

Rahhal, Amer. "Identification and Quantification of Fibrosis and Adipose Tissue of the Atrial Myocardium using Cardiac Magnetic Resonance Imaging." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS588.

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La fibrillation auriculaire est le plus souvent associée à une cardiomyopathie atriale composée de fibrose et d’infiltrats fibro-adipeux. L’identification de cette myopathie atrial en clinique est difficile, l’IRM qui permet l’imagerie tissulaire pourrait être un précieux outil diagnostic de la cardiomyopathie atriale. Méthodes: Etude de la déformation de la paroi libre de l’oreillette gauche (OG) par technique de « tracking IRM » (PLA) réalisée chez 13 patients, 24 heures avant une intervention de chirurgie valvulaire mitrale. 13 patients contrôles ont été inclus. Au cours de l’intervention,

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3

ASMUNDIS, C. DE. "RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150146.

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Introduction: Cardiac fibrosis is a pathological response that causes abnormalities in cardiac conduction and mechanical function, thereby contributing to the pathophysiology of a variety of cardiac conditions, including hypertrophy, failure, and arrhythmias. Atrial fibrillation (AF) is the most common sustained clinical arrhythmia and is a major cause of population morbidity and mortality. Recent studies have demonstrated that structural remodeling, involving prominent fibrotic changes, is a fundamental determinant of the perpetuation of AF, and contributes synergistically with electrical rem

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4

Moubarak, Majed. "Étude des effets du peptide natriurétique atrial sur les fibroblastes : implication physiopathologique dans le remodelage cardiaque." Thesis, Poitiers, 2014. http://www.theses.fr/2014POIT2312/document.

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L'ANP est une hormone cardiaque libérée lors de l'insuffisance cardiaque. Les fibroblastes cardiaques, responsables de la synthèse des composants de la matrice extracellulaire (MEC), acquièrent dans les conditions pathologiques la capacité de se différencier en myofibroblastes, conduisant ainsi à une fibrose cardiaque. Les mécanismes de régulation impliquant l'ANP et ses récepteurs (NPR) restent peu connus et font l'objet de ce travail. Les fibroblastes ventriculaires ont été isolés à partir de coeurs de rats Wistar et mis en culture afin d'induire leur différenciation. Les cultures ont ensuit

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5

Mastrorilli, Antonio Pio. "Mappaggio t1 in risonanza magnetica per la quantificazione della fibrosi atriale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/9991/.

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La tesi descrive il T1 mapping, un metodo diagnostico non invasivo emergente per l’identificazione e la quantificazione della fibrosi atriale. Nel primo capitolo ci si è soffermati sulle caratteristiche del tessuto fibrotico e sulle cause che generano tale patologia tra cui la fibrillazione atriale. Nel secondo capitolo vengono descritte le tecniche non invasive comunemente più utilizzate per la valutazione della fibrosi tra cui: sistemi di mappaggio elettronanatomico e risonanza magnetica cardiaca con l’uso di mezzo di contrasto. Nel terzo capitolo sono approfondite tutte le sequenze necess

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6

Leonardi, Roberta. "Segmentazione automatica dell'atrio sinistro e valutazione della fibrosi atriale in risonanza magnetica." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6427/.

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Questo lavoro di tesi si è svolto in collaborazione con le Unità Operative di Cardiologia e di Radiologia dell’ospedale “M. Bufalini” di Cesena e della St. Jude Medical, Inc., con l’obiettivo di sviluppare e implementare un metodo per l’identificazione e la valutazione della fibrosi atriale mediante risonanza magnetica in pazienti con fibrillazione atriale, candidati a procedura di ablazione. I pazienti sono stati sottoposti all’esame di risonanza magnetica (RM) angio per la valutazione della morfologia atriale e alla DE-MRI per l’identificazione e la visualizzazione delle zone di alto enhanc

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7

Margara, Francesca. "Studio e valutazione del legame tra rimodellamento elettrico e strutturale in Fibrillazione Atriale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9619/.

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La Fibrillazione Atriale (FA) è una delle aritmie più frequentemente riscontrate nella pratica clinica, ma i meccanismi che la generano e che la sostengono non sono ancora oggi ben chiari. L’obiettivo di questo lavoro di tesi è indagare il substrato aritmogeno della FA con particolare attenzione al legame tra rimodellamento elettrico e strutturale. La tecnica di riferimento per la valutazione della fibrosi è la risonanza magnetica con iniezione di mezzo di contrasto e acquisizione ritardata. Tipicamente, però, la presenza di fibrosi viene valutata durante la procedura di ablazione transcatet

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8

Onofri, Claudio. "Design e sviluppo di un nuovo algoritmo di segmentazione basato su CNN per la stima della volumetria atriale sinistra in pazienti con fibrillazione atriale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25390/.

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In questo studio si è sviluppato un nuovo algoritmo per la segmentazione dell'endocardio atriale sinistro, per pazienti affetti da fibrillazione atriale. A differenza delle convenzionali tecniche di segmentazione, si è fatto uso di una rete neurale convoluzionale chiamata U-Net, che è stata appositamente addestrata in modo supervisionato e testata, con dati MRI-GE e relativa etichetta di segmentazione binaria, dei volumi appartenenti a 154 pazienti diversi. Per l'addestramento si è fatto uso dei volumi di 123 pazienti (80%) e 31 pazienti sono dedicati al test (20%). Le CNN richiedono molto tem

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9

Cacciatore, Angela [Verfasser], and Hans-Ruprecht [Akademischer Betreuer] Neuberger. "Prokollagen Propeptide : Marker für atriale Fibrose und Vorhofflimmern? / Angela Cacciatore. Betreuer: Hans-Ruprecht Neuberger." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1052907148/34.

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10

Baliga, Reshma S. "Roles and mechanisms of oxidant stress in cardiovascular disease." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092841524.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 18.

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11

Andalò, Alice. "Quantificazione della fibrosi in atrio sinistro da immagini di risonanza magnetica con contrasto in pazienti affetti da fibrillazione atriale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15570/.

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La scelta del trattamento migliore per un soggetto affetto da fibrillazione atriale, risulta dipendere da un gran numero di variabili legate al quadro clinico del paziente. L’ablazione transcatetere delle vene polmonari è, ad oggi, una delle strategie di maggior successo per il ripristino e il mantenimento del ritmo sinusale. Tuttavia, l’esito della procedura è difficile da prevedere sul singolo paziente e in molti casi per ottenere il ripristino del ritmo sinusale e il controllo dei sintomi risultano necessarie ulteriori ablazioni. Recenti studi hanno correlato l’informazione sull’estension

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12

Hansen, Brian Josef. "Uncovering Reentrant Drivers of Atrial Fibrillation in the Human Heart." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1582637810923286.

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13

Sánchez, Arciniegas Jorge Patricio. "A Multiscale in Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation. A Translational Study to Guide Ablation Therapy." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/171456.

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[ES] La fibrilación auricular es la arritmia cardíaca más común. Durante la fibrilación auricular, el sustrato auricular sufre una serie de cambios o remodelados a nivel eléctrico y estructural. La remodelación eléctrica se caracteriza por la alteración de una serie de canales iónicos, lo que cambia la morfología del potential de transmembrana conocido como potencial de acción. La remodelación estructural es un proceso complejo que involucra la interacción de varios procesos de señalización, interacción celular y cambios en la matriz extracelular. Durante la remodelación estructural, los fibro

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14

Selzer, Christian [Verfasser], and Ulrich [Akademischer Betreuer] Laufs. "Bedeutung des Mineralocorticoid-Rezeptors für die entstehung atrialer Fibrose bei Vorhofflimmern / Christian Selzer. Betreuer: Ulrich Laufs." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1069104221/34.

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15

Löhfelm, Björn [Verfasser], and Ulrich [Akademischer Betreuer] Laufs. "Bedeutung der miRNA-21 für die Pathogenese der atrialen Fibrose und Vorhofflimmern / Björn Löhfelm. Betreuer: Ulrich Laufs." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1053725930/34.

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16

Lucas, Jason Anthony. "Counterregulatory roles of transforming growth factor (TGF)-[beta] and a trial natruiretic peptide (ANP) in pressure overload-induced cardiac remodeling and fibrosis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/lucas.pdf.

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17

Chen, Juan [Verfasser], Thomas [Akademischer Betreuer] Arentz, and Amir S. [Akademischer Betreuer] Jadidi. "Extent and spatial distribution of left atrial arrhythmogenic sites, late gadolinium enhancement at magnetic resonance imaging, and low-voltage areas in patients with persistent atrial fibrillation: comparison of imaging vs. electrical parameters of fibrosis and arrhythmogenesis." Freiburg : Universität, 2019. http://d-nb.info/1194312691/34.

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18

Cameli, Matteo. "Mechanical and histological disturbances in advanced heart failure and cardiac transplantation." Doctoral thesis, Umeå universitet, Kardiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127295.

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The general purpose of this thesis is to establish capability and accuracy of speckle tracking echocardiography (STE) in assessing left atrial (LA), left ventricular (LV) and right ventricular (RV) function and their correlation with myocardial fibrosis, filling pressure and clinical outcomes in advanced heart failure (HF) patients before and after heart transplantation (HT). I demonstrated that HT recipients had impaired LV twist dynamics in the form of reduced rotation twist angle and untwist rate but time to peak twist was not different from the age matched controls and other cardiac surgic

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19

Käräjämäki, A. (Aki). "Non-alcoholic fatty liver disease (NAFLD):perspectives to etiology, complications and lipid metabolism." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526217376.

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Abstract Obesity, insulin resistance, type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) form a dangerous quartet which threatens human health all over the world. About 25% of adults around the world have NAFLD, which poses risks for cardiovascular and metabolic well-being and may develop into liver cirrhosis and hepatocellular carcinoma. Apart from lifestyle modification, treatment options for NAFLD are scarce. This thesis presents atrial fibrillation (AF) as a new complication of NAFLD among general population of 958 individuals aged 40-60 years participating in the OPERA st

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20

Huber, Adrian Thomas. "Multi-organ non-invasive tissue characterization of fibrosis, adipose tissue, edema and inflammation with magnetic resonance (MR) imaging : applications to myocardium, skeletal muscle and liver interactions Cardiac MR strain: a noninvasive biomarker of fibro-fatty remodeling of the left atrial myocardium Comparison of MR T1 and T2 mapping parameters to characterize myocardial and skeletal muscle involvement in systemic Idiopathic Inflammatory Myopathy (IIM) Non-invasive differentiation of acute viral myocarditis and idiopathic inflammatory myopathy with cardiac involvement using magnetic resonance imaging T1 and T2 mapping CT predicts liver fibrosis: Prospective evaluation of morphology- and attenuationbased quantitative scores in routine portal venous abdominal scans." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS135.

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Cette thèse réalise une preuve de concept pour quantifier la déformation de l’oreillette gauche (OG) en IRM, ainsi que la relaxométrie IRM dans le myocarde, dans les muscles squelettiques et dans le foie. Grâce à l’interaction entre radiologues et ingénieurs, deux logiciels différents ont été développés, appliqués et validés pour l'analyse de la déformation myocardique multi-chambre et pour la cartographie quantitative du T1 multi-organes. La première publication a montré une forte corrélation de la déformation de l’OG, avec le degré de remplacement fibro-graisseux en histologie. Ce biomarqueu

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21

Bolzan, Bruna. "CORRELATION BETWEEN EPICARDIAL ADIPOSE TISSUE AND ATRIAL FIBRILLATION BURDEN IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY." Doctoral thesis, 2020. http://hdl.handle.net/11562/1017628.

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ABSTRACT Background: The epicardial adipose tissue is located between the myocardium and the visceral pericardium, lying directly above the myocardium without any fascia. Epicardial adipose tissue presents itself with histological features typical of the brown adipose tissue. It plays a cardioprotective role through thermoregulation, energy homeostasis and anti-inflammatory regulation. However, in pathological conditions, epicardial adipose tissue may have a pro-inflammatory effect. Less is known about the role played by epicardial adipose tissue in patients with a history of atrial fibrillati

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22

Al-u'datt, Doa'a. "LOX and LOX-Like Proteins as Potential Therapeutic Target for Atrial Fibrillation." Thèse, 2019. http://hdl.handle.net/1866/22593.

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23

RICCIARDI, GIUSEPPE. "Predittori di efficacia dell’isolamento delle vene polmonari nel trattamento della fibrillazione atriale." Doctoral thesis, 2015. http://hdl.handle.net/2158/1010611.

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24

Fakuade, Funsho Emmanuel. "An integrative and translational assessment of altered atrial electrophysiology, calcium handling and contractility in patients with atrial fibrillation." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-14F1-4.

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25

Wandelt, Laura Kristin. "Magnetresonanztomographische Detektion von Fibrose im linken Vorhof bei Patienten nach Schlaganfall." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0003-C15E-A.

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26

Twomey, Darragh Joseph. "The Impact of Weight Fluctuation on Atrial Substrate and the Prevention of Atrial Remodelling With the Use of Anti-Fibrotics." Thesis, 2016. http://hdl.handle.net/2440/119674.

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Atrial fibrillation (AF) is the commonest sustained arrhythmia in humans and is responsible for a significant socioeconomic burden. Affected individuals can suffer significant symptoms and are at risk of potentially life-threatening complications. Obesity is increasingly recognised as risk factor for the development of this arrhythmia. Weight fluctuation is common during attempted weight loss and has detrimental cardiovascular effects in human cohort studies, including patients with AF. However, the pathophysiological mechanisms by which this occurs are unclear. The first aim of this thesis is

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27

Lisi, Matteo. "Insights into left atrial response to pressure and volume overload." Doctoral thesis, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127294.

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The general purpose of this thesis is to establish the ability of Speckle Tracking Echocardiography (STE) in assessing left atrial (LA) response to pressure and volume overload respectively in aortic stenosis (AS) and mitral regurgitation (MR), and to evaluate its accuracy in predicting LA and right ventricular (RV) fibrosis in patients with end-stage heart failure (HF) undergoing heart transplantation (HTx). I demonstrated that assessment of left ventricular (LV) long axis systolic velocity and amplitude of excursion is more sensitive than simple determination of ejection fraction (EF) for re

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28

TSAI, YI-TING, and 蔡宜廷. "B-type Natriuretic Peptide Enhances Fibrotic Effects via Matrix Metalloproteinase-2 Expression in the Mouse Atrium in vivo and in Human Atrial Myofibroblasts in vitro." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/26m77m.

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博士<br>國防醫學院<br>醫學科學研究所<br>107<br>B-type natriuretic peptide (BNP) was approved by the US Food and Drug Administration in 2001 for the treatment of heart failure. However, the effects of BNP in clinical applications are controversial and uncertain. Recently, study indicated that high BNP levels are associated with an increased risk of developing atrial fibrillation. In this study, we investigated the direct effects of BNP on TNF--induced atrial fibrosis mice, as well as its effects on human atrial myofibroblasts. We found that injecting TNF--induced mice with recombinant human BNP enhanced at

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