Relevant bibliographies by topics / ATP

Academic literature on the topic 'ATP'

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Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "ATP"

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WATANABE, Kimiko, Satsuki TOMIOKA, Kiyoko TANIMURA, Hisae OKU, and Koichiro ISOI. "Uptake of AMP, ADP, and ATP inEscherichia coliW." Bioscience, Biotechnology, and Biochemistry 75, no. 1 (January 23, 2011): 7–12. http://dx.doi.org/10.1271/bbb.100063.

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Schultz, V., I. Sussman, K. Bokvist, and K. Tornheim. "Bioluminometric Assay of ADP and ATP at High ATP/ADP Ratios: Assay of ADP After Enzymatic Removal of ATP." Analytical Biochemistry 215, no. 2 (December 1993): 302–4. http://dx.doi.org/10.1006/abio.1993.1591.

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3

Schulte, P. M., C. D. Moyes, and P. W. Hochachka. "Integrating metabolic pathways in post-exercise recovery of white muscle." Journal of Experimental Biology 166, no. 1 (May 1, 1992): 181–95. http://dx.doi.org/10.1242/jeb.166.1.181.

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Purine nucleotides (ATP, ADP, AMP, IMP), creatine, phosphocreatine, lactate, pyruvate and glycogen were measured in rainbow trout (Oncorhynchus mykiss) white muscle following exercise to exhaustion. Estimates of intracellular pH permitted calculation of free concentrations of nucleotides ([nucleotide]f) required for most models of control of energy metabolism. Creatine charge, [PCr]/([PCr]+[Cr]), fell from 0.49 +/− 0.05 (mean +/− S.E.M.) to 0.08 +/− 0.02 with exercise but recovered completely by the first sample (2 h). Although [ATP] declined to 24% of resting levels and recovered very slowly, RATP, [ATP]/([ATP]+[ADP]f+[AMP]f), and energy charge, EC, ([ATP]+0.5[ADP]f)/([ATP]+[ADP]f+[AMP]f), recovered as quickly as creatine charge. Changes in [IMP] mirrored those in [ATP], suggesting that AMP deaminase is responsible for maintaining RATP and EC. Recovery of carbon status was much slower than recovery of energy status. Lactate increased from 4 mumol g-1 at rest to 40 mumol g-1 at exhaustion and did not recover for more than 8 h. Glycogen depletion and resynthesis followed a similar time course. During the early stages of recovery, calculated [ADP]f declined by more than 10-fold relative to the resting values. The resulting high [ATP]/[ADP]f ratios may limit the rate at which white muscle mitochondria can produce ATP to fuel glycogenesis in situ. It is postulated that the high [ATP]/[ADP]f ratios are required to drive pyruvate kinase in the reverse direction for glyconeogenesis in recovery.
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Duval, M., A. R. Beaudoin, G. Bkaily, F. P. Gendron, and P. D'Orléans-Juste. "Characterization of the NTPDase activities in the mesentery pre- and post-capillary circuits of the guinea pig." Canadian Journal of Physiology and Pharmacology 81, no. 3 (March 1, 2003): 212–19. http://dx.doi.org/10.1139/y03-043.

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NTPDase is one of the principal enzymes involved in the sequential hydrolysis of ATP. In the present study, the presence and functionality of NTPDase in the mesenteric vein and artery were examined. Adenosine triphosphate (ATP) (0.01–1000 pmol) induces a dose-dependent vasodilation in the isolated arterial and venous mesenteric vasculatures of the guinea pig. Adenosine diphosphate (ADP) (0.01–1000 pmol) but not adenosine monophosphate (AMP) (0.01–1000 pmol) induces a similar response in the mesenteric vascular circuit. L-NAME, a nitric oxide synthase inhibitor (200 µM, 30 min), significantly reduces the arterial dilatory effect of ATP and abolishes the responses to ADP and AMP. Complete removal of the endothelium with 3-[(3-cholamidopropyl) dimethylammonio]-1-propansulfonate (CHAPS) (20 mM, 2 × 45 s) abolishes ATP-induced responses. Infusion of ATP in the vascular circuit generated detectable amounts of ADP and AMP, as measured by HPLC. CHAPS treatment significantly reduced the level of ATP and the production of AMP in the arterial mesenteric circuit. In contrast to the arterial mesenteric vasculature, endothelium removal in the venous circuit triggered a marked potentiation of ADP release and, interestingly, a marked reduction in the release of AMP. Moreover, a specific inhibitor of NTP diphosphohydrolase, 1-hydroxynaphthlene-3,6-disulfonic acid BGO 136 (10 mM for 20 min), significatively reduced AMP production in both vascular preparations. These results confirm that the endothelium contributes to the vasoactive properties of ATP, ADP, and AMP. Our data also demonstrated a significant role of endothelium in NTPDase activity on ADP and AMP production prior to exogenous administration of ATP. The activity of this particular enzyme appears to be different from the reaction products viewpoint (i.e., the production of ADP) in the pre- and post-mesenteric circuits, suggesting two different isoforms with different substrate specificities.Key words: ATP, ADP, AMP, NTPDase, mesenteric vasculature.
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BAKKE, MIKIO, and SHIGEYA SUZUKI. "Development of a Novel Hygiene Monitoring System Based on the Detection of Total Adenylate (ATP+ADP+AMP)." Journal of Food Protection 81, no. 5 (April 3, 2018): 729–37. http://dx.doi.org/10.4315/0362-028x.jfp-17-432.

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ABSTRACT ATP is the universal energy molecule found in animals, plants, and microorganisms. ATP rapid hygiene monitoring tests have been employed in the food industry to ensure that adequate cleanliness is being maintained. However, because ATP is hydrolyzed to ADP and AMP by metabolic processes, by heat treatment, or under acidic or alkaline conditions, total adenylate (ATP+ADP+AMP [A3]) could be a more reliable sanitation indicator of food residues that may cause biofilm formation and allergen contamination. Therefore, a novel hygiene monitoring system to measure A3 was developed based on the luciferin-luciferase assay with the combination of two enzymes, pyruvate kinase and pyruvate phosphate dikinase, that can convert ADP into ATP and recycle AMP into ATP, respectively. The newly developed A3 assay system afforded stable bioluminescence signals and equivalent linear calibration curves between relative light units (RLU) and the amounts of ATP, ADP, and AMP, respectively. To verify the significance of the A3 method, the ratios of ATP, ADP, and AMP in various food samples were determined; large amounts of ADP and AMP were found in a variety of foods, such as meat, seafood, dairy, nuts, fruits, vegetables, and fermented foods. Sanitation monitoring of stainless steel exposed to raw meat was also examined, and the A3 method achieved a 200-RLU level, the typical benchmark value, after complete washing with detergent and rinsing. In contrast, a conventional ATP method showed less than 200 RLU after only a light cold and hot water rinse. In conclusion, the A3 assay appeared to be suitable for detection of adenylates from food residues that are not detected by the conventional ATP assay.
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Resnick, Sol M., and Alexander J. B. Zehnder. "In Vitro ATP Regeneration from Polyphosphate and AMP by Polyphosphate:AMP Phosphotransferase and Adenylate Kinase from Acinetobacter johnsonii 210A." Applied and Environmental Microbiology 66, no. 5 (May 1, 2000): 2045–51. http://dx.doi.org/10.1128/aem.66.5.2045-2051.2000.

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ABSTRACT In vitro enzyme-based ATP regeneration systems are important for improving yields of ATP-dependent enzymatic reactions for preparative organic synthesis and biocatalysis. Several enzymatic ATP regeneration systems have been described but have some disadvantages. We report here on the use of polyphosphate:AMP phosphotransferase (PPT) fromAcinetobacter johnsonii strain 210A in an ATP regeneration system based on the use of polyphosphate (polyP) and AMP as substrates. We have examined the substrate specificity of PPT and demonstrated ATP regeneration from AMP and polyP using firefly luciferase and hexokinase as model ATP-requiring enzymes. PPT catalyzes the reaction polyP n + AMP → ADP + polyP n−1. The ADP can be converted to ATP by adenylate kinase (AdK). Substrate specificity with nucleoside and 2′-deoxynucleoside monophosphates was examined using partially purified PPT by measuring the formation of nucleoside diphosphates with high-pressure liquid chromatography. AMP and 2′-dAMP were efficiently phosphorylated to ADP and 2′-dADP, respectively. GMP, UMP, CMP, and IMP were not converted to the corresponding diphosphates at significant rates. Sufficient AdK and PPT activity in A. johnsonii 210A cell extract allowed demonstration of polyP-dependent ATP regeneration using a firefly luciferase-based ATP assay. Bioluminescence from the luciferase reaction, which normally decays very rapidly, was sustained in the presence of A. johnsonii 210A cell extract, MgCl2, polyP n=35, and AMP. Similar reaction mixtures containing strain 210A cell extract or partially purified PPT, polyP, AMP, glucose, and hexokinase formed glucose 6-phosphate. The results indicate that PPT from A. johnsonii is specific for AMP and 2′-dAMP and catalyzes a key reaction in the cell-free regeneration of ATP from AMP and polyP. The PPT/AdK system provides an alternative to existing enzymatic ATP regeneration systems in which phosphoenolpyruvate and acetylphosphate serve as phosphoryl donors and has the advantage that AMP and polyP are stabile, inexpensive substrates.
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Vetri, Francesco, Haoliang Xu, Lizhen Mao, Chanannait Paisansathan, and Dale A. Pelligrino. "ATP hydrolysis pathways and their contributions to pial arteriolar dilation in rats." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 4 (October 2011): H1369—H1377. http://dx.doi.org/10.1152/ajpheart.00556.2011.

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ATP is thought to be released to the extracellular compartment by neurons and astrocytes during neural activation. We examined whether ATP exerts its effect of promoting pial arteriolar dilation (PAD) directly or upon conversion (via ecto-nucleotidase action) to AMP and adenosine. Blockade of extracellular direct ATP to AMP conversion, with ARL-67156, significantly reduced sciatic nerve stimulation-evoked PADs by 68%. We then monitored PADs during suffusions of ATP, ADP, AMP, and adenosine in the presence and absence of the following: 1) the ecto-5′-nucleotidase inhibitor α,β-methylene adenosine 5′-diphosphate (AOPCP), 2) the A2 receptor blocker ZM 241385, 3) the ADP P2Y1 receptor antagonist MRS 2179, and 4) ARL-67156. Vasodilations induced by 1 and 10 μM, but not 100 μM, ATP were markedly attenuated by ZM 241385, AOPCP, and ARL-67156. Substantial loss of reactivity to 100 μM ATP required coapplications of ZM 241385 and MRS 2179. Dilations induced by ADP were blocked by MRS 2179 but were not affected by either ZM 241385 or AOPCP. AMP-elicited dilation was partially inhibited by AOPCP and completely abolished by ZM 241385. Collectively, these and previous results indicate that extracellular ATP-derived adenosine and AMP, via A2 receptors, play key roles in neural activation-evoked PAD. However, at high extracellular ATP levels, some conversion to ADP may occur and contribute to PAD through P2Y1 activation.
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Chen, G., and H. Suzuki. "Endothelium-dependent hyperpolarization elicited by adenine compounds in rabbit carotid artery." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 4 (April 1, 1991): H1037—H1042. http://dx.doi.org/10.1152/ajpheart.1991.260.4.h1037.

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Electrical responses of the membrane of intimal and adventitial smooth muscle cells of the rabbit carotid artery to ATP, ADP, AMP, and adenosine were recorded. In intimal cells, these compounds hyperpolarized the membrane. Mechanical removal of the endothelium altered the responses to ATP and ADP to one of a transient depolarization, with no alteration of the response to AMP and adenosine. In the adventitial cells, ATP and ADP produced a transient depolarization, whereas AMP and adenosine produced a sustained hyperpolarization, irrespective of the presence or absence of the endothelium. In tissues with an intact endothelium, 5'-adenylylimidodiphosphate tetralithium salt and alpha,beta-methylene ATP (mATP) transiently depolarized the membrane in these smooth muscles. In case of stabilization with mATP, only hyperpolarization was generated by ATP, in an endothelium-dependent manner. Our interpretation of these observations is that 1) ATP and ADP depolarize smooth muscle membrane by a direct action and hyperpolarize the membrane indirectly through the release of endothelium-derived hyperpolarizing factor, 2) AMP and adenosine hyperpolarize the membrane, independently of the endothelium, and 3) ATP receptors present on the endothelial cell membrane differ from those on smooth muscle membrane.
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Warburton, D., S. Buckley, and L. Cosico. "P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes." Journal of Applied Physiology 66, no. 2 (February 1, 1989): 901–5. http://dx.doi.org/10.1152/jappl.1989.66.2.901.

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Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP was 10(-4) M. The rank order of agonists for PC exocytosis was ATP greater than ADP greater than AMP greater than adenosine greater than alpha,beta-methylene ATP. The rank order of agonists for phosphatidylinositol (PI) hydrolysis was ATP greater than ADP, whereas AMP, adenosine, and alpha,beta-methylene ATP did not stimulate PI hydrolysis. ATP (10(-4) M) caused a 15-fold increase in adenosine 3′,5′-cyclic monophosphate (cAMP) production, and the nonmetabolizable adenosine analogue 5′-N-ethylcarboxyamidoadenosine (10(-6) M) increased cAMP production threefold. The effects of both these agonists on cAMP production were completely inhibited by the adenosine antagonist 8-phenyltheophylline (10(-5) M). The effects of ATP (10(-4) M) on PC exocytosis were inhibited 38% by 10(-5) M 8-phenyltheophylline. Thus, ATP regulates PC exocytosis by activating P2 receptors, which stimulate PI hydrolysis to inositol phosphate, as well as by activating P1 receptors, which stimulate cAMP production. Interactions between the P1 and P2 pathways may explain the high potency of extracellular ATP as an agonist of PC exocytosis.
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Ko, W. H., J. J. O'Dowd, J. D. Pediani, D. L. Bovell, H. Y. Elder, D. M. Jenkinson, and S. M. Wilson. "Extracellular ATP can activate autonomic signal transduction pathways in cultured equine sweat gland epithelial cells." Journal of Experimental Biology 190, no. 1 (May 1, 1994): 239–52. http://dx.doi.org/10.1242/jeb.190.1.239.

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Changes in intracellular free calcium concentration ([Ca2+]i) were monitored in a cell line that was derived from the equine sweat gland epithelium. ATP and closely related compounds could increase [Ca2+]i with a rank order of potency of UTP > or = ATP > ADP > AMP = adenosine = alpha,beta-methylene-ATP. The responses to ATP and to UTP were initiated by the release of calcium from an internal store and subsequently sustained by calcium influx. The rise in [Ca2+]i thus seems to be mediated by P2U receptors that are coupled to phosphoinositidase C. Some desensitisation of this response developed during repeated stimulation with ATP and this was blocked by staurosporine, an inhibitor of protein kinase C, and augmented by a phorbol ester which acts as an exogenous activator of this enzyme. A protein-kinase-C-dependent inhibitory pathway thus seems to become active during repeated stimulation with ATP. ATP and related compounds could also raise cellular cyclic AMP content. The order of potency was ATP > ADP = AMP = adenosine > UTP, suggesting that this response is mediated via a separate subclass of P2 receptor. The present results demonstrate that ATP can activate autonomic signal-transduction pathways in cultured equine sweat gland cells and suggest that there may be a purinergic component to the control of secretory activity in the equine sweat gland.
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Dissertations / Theses on the topic "ATP"

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Sperotto, Rita Leal. "Hidrólise de atp e adp em líquor humano." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/11088.

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Adenine nucleotides hydrolysis is an important step of the neuromodulation of CNS and some of its breakdown products are able to protect the nervous tissue against brain injuries. The activity of NTPDase (EC 3.6.1.5, apyrase, CD39) was verified in cerebrospinal fluid (CSF) from patients without neural inflammatory process under different conditions and in the presence of several inhibitors. The samples were chose considering the low protein levels, normal glucose levels, low leukocyte count and CSF differential count. We chose use the supernatant 1 (S1) for enzyme assay due to the best enzymatic activities in this fraction. The best hydrolyze temperature was 37°C to ATP and ADP. This enzyme was cation-dependent, with a maximal rate for ATP and ADP hydrolysis in pH 8.0 in the presence of 5mM Ca+2. Sodum azide inhibited both nucleotide hydrolysis at concentrations higher than 10 mM. Sodium fluoride inhibited the ATP and ADP hydrolysis at concentrations of 15 mM and 20 mM. The Na+ K+ ATPase inhibitor ouabain, did not affect ATP or ADP hydrolysis. The inhibitor P-type ATPase lanthanum 5mM was ineffective on ATPDase hydrolysis. Suramin (30-300 μM) inhibited ATP and ADP hydrolysis and presented a maximal inhibitory effect of 50% at 300 μM. The results of the present study demonstrated that ATP and ADP hydrolysis from human CSF presented a similar response those obtained from rat synaptosomes.
A análise do líquor é de grande importância para a detecção de desordens neurológicas de diversas etiologias. O ATP junto a seus produtos de hidrólise (ADP, AMP e adenosina) desempenha importantes funções junto ao SNC, as quais envolvem ações neuroprotetoras em doenças de etiologias variadas. O presente estudo tem como objetivos verificar a ocorrência de hidrólise de nucleotídeos da adenina em líquor de pacientes sem doença inflamatória do sistema nervoso. A determinação da atividade enzimática da NTPDase foi feita em líquor humano em diferentes condições experimentais e na presença de inibidores. As amostras foram escolhidas de acordo com os baixos níveis protéicos, valores normais de glicose e contagem celular diminuída. Foi escolhido o sobrenadante 1 (S1) por apresentar melhores atividades enzimáticas. A melhor temperatura de hidrólise do ATP e ADP foi 37°C. Esta enzima é cátion dependente, sendo a atividade de hidrólise ótima do ATP em presença de 5 mM Ca+2 e o ADP 5-7 mM de Ca+2, ambos em pH 8.0. A azida sódica alterou a atividade enzimática do ATP e do ADP somente nas concentrações mais altas deste inibidor da ATPase mitocondrial. A ouabaína, um inibidor da Na+/K+ ATPase não afetou a hidrólise do ATP/ADP. O inibidor de ATPase tipo-P lantânio (5 mM) foi ineficaz na hidrólise dos nucleotídeos. O suramin (30-300 XM), inibidor específico de NTPDase, inibiu a hidrólise do ATP/ADP e apresentou máximo efeito inibitório na concentração de 300 XM. Os resultados deste estudo mostraram que a hidrólise de ATP/ADP em líquor humano apresentou uma resposta semelhante àquelas obtidas em sinaptossomas de ratos.
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HATIN, ISABELLE. "L'adenylate translocase : un adp/atp transporteur chez plasmodium falciparum." Paris 7, 1994. http://www.theses.fr/1994PA077245.

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L'adp/atp transporteur catalyse l'echange adp/atp a travers la membrane interne des mitochondries. La proteine fonctionnelle est un dimere de deux sous unites identiques de 30 a 34 kda chaque, codee par le genome nucleaire. Cette proteine appartient a une superfamille de transporteurs mitochondriaux. L'objectif de ce travail etait de montrer la presence d'un gene codant pour un adp atp transporteur chez p. Falciparum. L'utilisation repetee de la pcr, nous a permis d'etablir qu'une sequence nucleotidique chez p. Falciparum code pour un polypeptide de 301 acides amines, homologue aux adt mitochondriales. L'alignement de cette sequence avec les sequences deja publiees pour d'autres organismes eucaryotes montre que l'adp/atp transporteur de p. Falciparum comporte toutes les sequences considerees comme importantes pour sa localisation intramembranaire ainsi que pour sa fonctionalite. Le profil d'hydrophilie revele six domaines hydrophobes, potentiellement transmembranaires. Le northern blot des arn a partir de cultures synchrones, montre un faible taux de transcription du messager specifique de l'adp/atp transporteur chez p. Falciparum. La quantification de ces arnm par hybridation in situ a revele une expression plus faible au stade trophozoite qu'au stade anneau et schizonte. Le gene codant pour ce transporteur chez p. Falciparum est localise sur le chromosome 10. L'immuno-electromicroscopie avec un anticorps polyclonal heterologue montre un marquage uniquement dans le membrane interne de la mitochondrie de p. Falciparum
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Lange, Ulf. "Elektrophysiologische Untersuchungen an rekombinanten kardiovaskulären K ATP -Kanälen Effekte von Nukleotiden, neuartigen K ATP -Kanalöffnern und Blockern /." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11947832.

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Kramarova, Tatiana. "Limiting factors in ATP synthesis." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-987.

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Harrington, R. A. "Evolution of ATP synthase." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603734.

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The hypothesis of modular evolution of the atp operon is re-evaluated by conducting a phylogenetic analysis of the atp operons and constituent genes of all fully sequenced genomes. Although the original hypothesis of modular evolution cannot be conclusively supported, a number of novel observations are made. Foremost is that the atp operon is a mosaic operon, a result of extensive horizontal transfer. In addition, two independent duplication events are proposed for subunits b/b’ of the enzyme, the transmembrane subunits I and z are shown to be more prevalent than previously thought, and an α/β gene pair is proposed as a putative ancestral gene duplication for these catalytic subunits. Further studies investigate the evolution and current importance of the P-loop domain, the nucleotide binding domain found with the α and β subunits of ATP synthase. A database has been developed to annotate the structure-function relationships of protein structural domains on a large-scale basis, including a novel facility to describe these relationships in terms of their taxonomic distribution. It is used in conjunction with the previously created PSIMAP structural interaction database and taxonomy databases to describe the P-loop as consistently one of the most diverse domains in the proteome. It is also represented by nodes at critical positions within both the structural interaction network, and a novel protein structure-function bipartite network, which supports the proposal that it is among the oldest and most successful of all domains. The final chapter presents case studies of three P-loop families, and explains the diversity of function, interaction partners and taxonomic distribution exhibited in terms of their structures and sequences. In particular a novel study comparing and contrasting the pore structures of all P-loop rings is presented, and partially conserved motifs in the G-proteins are described to explain their interactivity.
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Sheldon, Jonathan Gary. "Control of ATP turnover." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627507.

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Woźnicka-Misăilă, Aleksandra. "An investigation and characterization of different ADP/ATP Carrier homologs." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV011/document.

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L'objectif principal de ce projet de thèse était d'obtenir de nouvelles données structurales sur les transporteurs ADP/ATP mitochondriaux et de développer des outils pour les approches de micro- et nano-cristallographie appliquées à la biologie structurale des protéines membranaires.Le rôle principal du transporteur ADP/ATP (AAC) est d'importer et d'exporter respectivement de l’ADP3- et l’ATP4- à travers la membrane mitochondriale interne, entre l'espace intermembranaire et la matrice. AAC est le transporteur mitochondrial le mieux caractérisé de toute cette famille de protéines. De nombreuses études ont été menées pour caractériser sa fonction et sa structure. Toutefois, les données structurales n’étant disponibles que pour une conformation de la protéine, de nombreuses questions fondamentales notamment sur les différents états conformationnels adoptés par la protéine au cours du processus de transport restent encore posées. Dans cette thèse, nous avons étudié les 4 isoformes humaines d’AAC. Elles sont impliquées dans diverses maladies génétiques, mais jouent également un rôle dans la cancérogenèse. Cette thèse décrit ainsi en détail la caractérisation structurale et fonctionnelle de ces protéines et leur comparaison. C’est est une étape essentielle pour définir leurs propriétés, et constitue un point de départ précieux dans le développement de nouvelles thérapies.Le domaine de la biologie structurale ne cesse de connaître de nouveaux développements, comme c’est le cas par exemple avec l’avènement de la cristallographie sérielle. Il y a donc un besoin constant de nouvelles approches notamment pour la préparation des échantillons, leur montage sur les lignes de lumière et les collectes de données afin de continuer à améliorer la qualité des données collectées au synchrotron. Ainsi, notre objectif était d'utiliser différents échantillons de protéines membranaires pour développer de nouvelles techniques de cristallisation et de montage d’échantillons sur les lignes de lumière afin de préserver au mieux la qualité des échantillons tout en permettant des collectes de données plus rapides, plus efficaces et plus simples
The main objective of this PhD project was to gain new structural data on the mitochondrial ADP/ATP carriers and develop tools for micro- and nano-crystallography approaches applied to membrane protein structural biology.The main role of the ADP/ATP carrier (AAC) is to import and export ADP3- and ATP4- respectively between the intermembrane space and the matrix through the inner mitochondrial membrane. AAC is the best characterized among all mitochondrial carriers. Much has been done to investigate its function and structure. However, since structural data are only available for one conformation of the protein some fundamental questions about the different conformational states adopted during the transport process still need to be answered.In this thesis we considered 4 human AAC homologs as a main target. They are involved in different genetic diseases but play also a role in cancerogenesis. This thesis describes and compares in detail the functional and structural characterization of the human AAC isoforms. It was an essential step to give insight into their native properties and is a precious starting point for the drug development field.Since the structural biology field is rapidly developing especially in serial crystallography techniques, there are more and more new applications for samples preparation, mounting and measurements in order to improve the quality of the data collected at the synchrotrons. Hence, our second objective was to use different membrane protein samples to develop new crystal-friendly crystallization set up combined with different sample environment on the beamline toward faster, more efficient and simpler data collection
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Rey, Martial. "Transporteur mitochondrial d'ATP/ADP : étude par échange hydrogène / deutérium couplé à la spectrométrie de masse et caractérisation de mutations pathogènes." Grenoble 1, 2009. http://www.theses.fr/2009GRE10320.

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Le tran'sporteur d'ADP/ATP est une protéine de la membrane interne mitochondriale qui joue un rôle physiologique majeur en catalysant l'échange d'un ADP cytoplasmique contre un A TP néo-synthétisé dans la matrice mitochondriale. Cette protéine peut être inhibée de manière très spécifique par deux poisons naturels, le carboxyatractyloside (CATR) et l'acide bongkrekique (BA) qui stabilisent la protéine dans deux états conformationnels distincts adoptés au cours du mécanisme de transport. Afin de mieux appréhender cette dynamique fonctionnelle, une étude du transporteur d'ADP/ATP bovin en complexe avec le CATR ou le BA dans le détergent Triton X-IOO a été réalisée par échange hydrogène/deutérium couplé à la spectrométrie de masse. Ces travaux se sont déroulés en 4 parties. La première a consisté à adapter cette technique à l'étude des protéines membranaires intégrales. En effet, la présence de détergents, nécessaires au maintien en solution de l'état natif de ces protéines, n'a pas permis jusqu'ici de les étudier par cette approche. Pour pallier cette difficulté, un protocole automatisé de chromatographie liquide permettant l'élimination du Triton X-IOO a été mis au point. Les cinétiques de deutération des différents complexes ont alors pu être analysées dans le deuxième volet de cette étude. Les données obtenues ont permis de proposer des modèles conformationnels du transport de nucléotides au travers de la membrane interne mitochondriale, dans lesquels le transporteur présenterait une cavité ouverte tour à tour vers l'espace intermembranaire et vers la matrice. Afin d'apporter d'autres éléments de réponse sur ce mécanisme de transport et de s'affranchir de différents problèmes liés à l'utilisation des détergents, des essais de deutération du transporteur d'ADP/ATP bovin dans les mitochondries ont été entrepris et représentent le troisième volet de ces travaux. Cette approche, qui nécessite encore plusieurs améliorations, a permis d'obtenir les premières données de deutération d'une protéine membranaire dans son environnement natif. Le transporteur d'ADP/ATP est aussi impliqué dans des pathologies humaines plus ou moins grave. Dans une dernière partie, l'étude de ces mutations a été abordée en réalisant chez la levure Saccharomyces cerevisiae une étude phénotypique et biochimique de plusieurs mutants du transporteur de l'amibe Dictyostelium discoideum correspondant aux mutations humaines. Cette étude a mis en évidence un problème dans le mécanisme intrinsèque de transport, induit par la mutation V291M, qui pourrait être à l'origine de la pathologie associée
The ADP/ATP carrier is a protein located in the inner membrane of the mitochondria. It plays a major physiological role by catalyzing the exchange of a cytoplasmic ADP against a newly synthesized A TP of the mitochondrial matrix. This protein could be inhibited very specifically by two natural poisons, the carboxyatractyloside (CATR) and the bongkrekic acid (BA), who stabilizes the protein in two distinct conformations involved in the transport mechanism. Ln order to understand this functional dynamic, a study of the ADP/ATP carrier in complex with the CATR or the BA carried out in micelles of detergent (Triton X-lOO) was realized by hydrogenldeuterium exchange coupled to a mass spectrometry analysis. This work was organized in 4 parts. The first part has consisted in an adaptation of this technique to integral membrane proteins. Indeed, the necessity of using detergent to maintain the native state of this kind of protein didn't allow using this approach to study them. To overcome this difficulty, an automatic protocol of liquid chromatography was set up and allows washing out the Triton X-lOO. Ln a second part ofthis work, exchange kinetics were analyzed. The collected data allow us to propose sorne conformational models of the nucleotide transport across the inner membrane. Ln these different models, the mitochondrial carrier would be alternatively open to the intermembrane space or to the matrix with different movements of the peptidic chain. Ln order to bring other data on this mechanism and to avoid several problems due to the detergent, sorne tries of deuteration of the bovine ADP/ATP carrier into the mitochondrial membrane were attempted. This represents the third part of this work. Even if this approach needed sorne amelioration, it provides us the first data of deuteration of a membrane protein in this native environment. The ADP/ATP carrier is also involved in severe human pathologies. Ln a last part, the study of these mutations was investigated. Several mutants of the unique ADP/ATP carrier of the amoeba Dictyostelium discoideum corresponding to human mutants was expressed in the yeast Saccharomyces cerevisiae. Analysis of the phenotype of the strains expressing mutated carriers and the measurement of the biochemical constants of these proteins have pointed out a problem in the intrinsic mechanism of transport due to the mutation V291M and could explain the associated pathology
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Schaffer, Veronika. "Bestimmung der ATP-Freisetzung und des ATP-Abbaus an peripheren Nerven mittels Lumineszenzmessung." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-94932.

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Hendon, Tyler. "IMPACT OF PHOSPHOINOSITIDES ON REGULATION OF K-ATP BY ATP AND HYDROGEN SULFIDE." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5556.

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Hydrogen sulfide (H2S) reduces ischemia reperfusion (IR) injury by stimulating adenosine triphosphate (ATP) sensitive potassium channels (KATP) [1-5]. Demonstrating H2S stimulation is unique to KATP, as other inwardly rectifying potassium (Kir) channels demonstrate inhibition or are unaffected [6]. We recently showed that H2S inhibits Kir2 and Kir3 by decreasing channel sensitivity to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) [6]. Here, we test the hypothesis that H2S regulation of Kir6.2, a pore-forming subunit of the KATP channel, is also dependent on PIP2. Using whole-cell patch-clamp we show that H2S increases the activity of Kir6.2 channels expressed in HEK-293 cells. To study the mechanism, we modulated PIP2 levels by expressing a light- activated phosphatase, or by including high levels of a water-soluble PIP2 analog in the patch pipette. The results suggest that H2S augmentation of Kir6.2 channel activity is increased when PIP2 levels are elevated.
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Books on the topic "ATP"

1

Ingwall, Joanne S. ATP and the Heart. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-1093-2.

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ATP and the heart. Boston: Kluwer Academic, 2002.

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R, Dubyak George, Fedan Jeffrey S, and New York Academy of Sciences., eds. Biological actions of extracellular ATP. New York, N.Y: New York Academy of Sciences, 1990.

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Boyd, K. T. ATP, airline transport pilot: A comprehensive text and workbook for the ATP written exam. 4th ed. Ames, Iowa: Iowa State University Press, 1994.

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T, Boyd K., ed. ATP, Airline transport pilot: A comprehensive text and workbook for the ATP written exam. 3rd ed. Ames: Iowa State University Press, 1988.

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ATP-FAR 135, airline transport pilot. 2nd ed. Ames: Iowa State University Press, 1990.

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Oster, George. ATP synthase: Two motors, two fuels. London: Current Biology Limited, 1999.

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Dimroth, Peter. The motor of the ATP synthase. Amsterdam: Elsevier, 1998.

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Boyd, K. T. ATP-FAR 135, airline transport pilot. 3rd ed. Ames: Iowa State University Press, 1994.

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E, Stanley P., McCarthy B. J, and Smither R, eds. ATP luminescence: Rapid methods in microbiology. Oxford [England]: Blackwell Scientific Publications, 1989.

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Book chapters on the topic "ATP"

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Biswas-Fiss, Esther E., Stephanie Affet, Malissa Ha, Takaya Satoh, Joe B. Blumer, Stephen M. Lanier, Ana Kasirer-Friede, et al. "ADP/ATP carrier." In Encyclopedia of Signaling Molecules, 82. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100048.

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Vogel, Sebastian. "ATP und ADP." In Zellbiologie 3, 5–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-55283-4_2.

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Miyakawa, Shin. "ATP." In Encyclopedia of Astrobiology, 123. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_134.

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Hangay, George, Severiano F. Gayubo, Marjorie A. Hoy, Marta Goula, Allen Sanborn, Wendell L. Morrill, Gerd GÄde, et al. "ATP." In Encyclopedia of Entomology, 323. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_10385.

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Miyakawa, Shin. "ATP." In Encyclopedia of Astrobiology, 208–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_134.

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Mehlhorn, Heinz. "ATP." In Encyclopedia of Parasitology, 241. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4528.

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Mehlhorn, Heinz. "ATP." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_4528-1.

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Böning, Dieter, Michael I. Lindinger, Damian M. Bailey, Istvan Berczi, Kameljit Kalsi, José González-Alonso, David J. Dyck, et al. "ATP." In Encyclopedia of Exercise Medicine in Health and Disease, 111. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2123.

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Miyakawa, Shin, and Kensei Kobayashi. "ATP." In Encyclopedia of Astrobiology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-642-27833-4_134-3.

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Karow, Julia. "ATP." In Biochemie 2, 17–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-55064-9_5.

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Conference papers on the topic "ATP"

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Qasem, Mamoun, Ahmed Al-Dubai, Romdhani Imed, and Muneer Bani Yassien. "ATP." In the The International Conference. New York, New York, USA: ACM Press, 2015. http://dx.doi.org/10.1145/2832987.2833058.

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Sundaresan, Karthikeyan, Vaidyanathan Anantharaman, Hung-Yun Hsieh, and Raghupathy Sivakumar. "ATP." In the 4th ACM international symposium. New York, New York, USA: ACM Press, 2003. http://dx.doi.org/10.1145/778415.778424.

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Rodríguez, Juan M., Hernan D. Merlino, and Patricia Pesado. "ATP-OIE." In ICCDA 2020: 2020 The 4th International Conference on Compute and Data Analysis. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3388142.3388166.

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Shu Xian-rong, He Bing-fa, and Long Wei-jun. "Query on reciprocity between ARP and ATP." In IET International Radar Conference 2009. IET, 2009. http://dx.doi.org/10.1049/cp.2009.0232.

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Coenraad, W. J. "ERTMS and ATP." In 2nd IEE Residential Course on Railway Electrification Infrastructure Systems. IEE, 2005. http://dx.doi.org/10.1049/ic:20050627.

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Fukuzawa, Noriyuki, Tatsuhiro Fukuba, and Teruo Fujii. "Development of in situ ATP quantitative analysis system "IISA-ATP"." In 2006 International Conference on Microtechnologies in Medicine and Biology. IEEE, 2006. http://dx.doi.org/10.1109/mmb.2006.251544.

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Qian, Yanrong, Yi Liu, Xuan Wang, and Xiaozhuo Chen. "Abstract 1703: Extracellular ATP mediated intracellular ATP increase: Evidence for transport of extracellular ATP into cancer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1703.

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Rikhvanov, E. G., I. F. Fedoseeva, N. N. Varakina, T. M. Rusaleva, A. V. Fedyaeva, A. V. Stepanov, and G. B. Borovskii. "ADP/ATP TRANSLOCATOR AND CELL REACTION ON STRESS EXPOSURE." In The Second All-Russian Scientific Conference with international participation "Regulation Mechanisms of Eukariotic Cell Organelle Functions". SIPPB SB RAS, 2018. http://dx.doi.org/10.31255/978-5-94797-318-1-103-105.

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Tanable, A., Y. Yatomi, T. Ohashi, H. Oka, T. Kariya, and S. Kume. "EFFECTS OF HUMAN ATRIAL NATRIURETIC PEPTIDES ON SECRETION REACTION IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644873.

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Human atrial natriuretic peptide (h-ANP) has vasodilating and natriuretic properties, and inhibits smooth muscle contraction, renal renin secretion and adrenal aldosterone release. Although Schiffrin has reported that human platelets have receptors for ANP, its effects in platelets are not established in vivo. We therefore investigated the influence of h-ANP on secretion reaction in human platelets. Eight healthy subjects, males, aged 20 to 24 years, donated blood for the study. Citrated platelet-rich plasma (PRP) was incubated with or without h-ANP at 37 C for 2.5 minutes. The samples of 0.5 ml PRP then used to measure ADP induced aggregation, ATP release reaction and C-serotonin release reaction. H-ANP, at concentration of 1x10 -6M, decreased ADP induced aggregation (after h-ANP: 77.4±9.7 % of control aggregation), and inhibited ATP release reaction (after h-ANP: 31.8±13.1%). Serotonin releasereaction induced by ADP was also inhibited ( control: 15.3±2.2%, after h-ANP: 8.3±0.5 %). The inhibitory effect of h-ANP on aggregation and secretion reaction was maximal by 3 minutes. These data suggest that h-ANP inhibits secretion reaction in human platelets.
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Wang, Xuan, Yunsheng Li, Yanrong Qian, Yanyang Cao, and Xiaozhuo Chen. "Abstract 42: A new type of drug resistance in cancer: extracellular ATP-induced resistance through ATP internalization and ATP-drug competition." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-42.

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Reports on the topic "ATP"

1

Scharlemann, E. Extending ATP to High Frequencies. Office of Scientific and Technical Information (OSTI), November 2011. http://dx.doi.org/10.2172/1107294.

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Russell, V. K. Cleanup MAC and MBA code ATP. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/10192501.

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Ho, Winston Z., Stephen Lee, and John Weimaster. Rapid ATP-Glow for Biological Decontamination Efficacy Test. Fort Belvoir, VA: Defense Technical Information Center, April 2003. http://dx.doi.org/10.21236/ada413266.

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Huff, J., and S. Ochsner. Update Analysis Implementation (UAI) Advanced Technical Prototype (ATP). Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada387653.

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Gruenhagen, Jason Alan. Bioanalytical Applications of Real-Time ATP Imaging Via Bioluminescence. Office of Scientific and Technical Information (OSTI), January 2003. http://dx.doi.org/10.2172/822057.

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Montemagno, Carlo. Development of a Generator to Power ATP-Driven Molecular Motors. Office of Scientific and Technical Information (OSTI), October 2002. http://dx.doi.org/10.2172/900245.

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Chang, Connie K. N. ATP eligibility criteria for U.S. subsidiaries of foreign-owned companies:. Gaithersburg, MD: National Institute of Standards and Technology, 1998. http://dx.doi.org/10.6028/nist.ir.6099.

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Keller, C. M. ATP for the portable 500 CFM exhauster POR-006 skid D. Office of Scientific and Technical Information (OSTI), July 1997. http://dx.doi.org/10.2172/325394.

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Keller, C. M. ATP for the portable 500 CFM exhauster POR-005 skid C. Office of Scientific and Technical Information (OSTI), June 1997. http://dx.doi.org/10.2172/325420.

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Keller, C. M. ATP for the portable 500 CFM exhauster POR-004 skid B. Office of Scientific and Technical Information (OSTI), May 1997. http://dx.doi.org/10.2172/362451.

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