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Relevant bibliographies by topics / Atherosclerosis; Carotid endarterectomy

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Academic literature on the topic 'Atherosclerosis; Carotid endarterectomy'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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Journal articles on the topic "Atherosclerosis; Carotid endarterectomy"

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Roberts, Charles Stewart. "Endarterectomy for Carotid Atherosclerosis." American Journal of Geriatric Cardiology 16, no. 4 (July 2007): 259–61. http://dx.doi.org/10.1111/j.1076-7460.2007.06224.x.

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Anysienkova, V. Ju. "Comparative characteristics of atherogenesis factors in patients with symptomatic and asymptomatic atherosclerotic carotid stenosis." PROBLEMS OF UNINTERRUPTED MEDICAL TRAINING AND SCIENCE 41, no. 1 (April 2021): 70–76. http://dx.doi.org/10.31071/promedosvity2021.01.070.

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To study a comparative assessment of risk factors for atherogenesis in patients with different clinical manifestations of carotid atherosclerotic stenosis. The study included 106 patients (men — 74, women — 32) aged 39 to 79 years (mean age 62.6 ± 0.9), which devided to 3 clinical groups: Group I — 35 patients with acute atherothrombotic stroke with ipsilateral carotid stenosis, group II — 41 patients after acute cerebrovascular events and carotid endarterectomy, group III — 30 patients with asymptomatic atherosclerotic carotid stenosis and the control group, which consisted of 20 relatively healthy individuals. The degree of stenosis of the internal carotid arteries was highest (> 70 %) in the group of patients who underwent carotid endarterectomy. In addition in this group was prevalence younger men, compared with the group of asymptomatic stenosis and women (p = 0.00300), there was an older age of patients and moderate stenosis of 50–69 % (p = 0.00647). In patients with stenotic atherosclerosis of the internal carotid artery, there was a significant increase in the level of Lp-PLA2 compared with the control. This confirms that Lp-PLA2 can be considered as a marker of carotid atherosclerosis and influence the development of ischemic stroke. The highest level of Lp-PLA2 was observed in the clinical group of patients who underwent carotid endarterectomy after ischemic stroke and there was a tendency to a more significant increase in total cholesterol. This suggests a more aggressive course of the atherosclerotic process in patients in this group.

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Jahromi, Babak S., Michael D. Hill, Kate Holmes, Stuart Hutchison, William S. Tucker, and Brian Chiu. "Chlamydia pneumoniae and Atherosclerosis following Carotid Endarterectomy." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 30, no. 4 (November 2003): 333–39. http://dx.doi.org/10.1017/s0317167100003048.

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Background:Seroepidemiological studies have shown an association between raised antibody titres against Chlamydia pneumoniae, and carotid atherosclerosis or stroke. However, direct evidence for a causal link between arterial infection with C. pneumoniae and carotid disease remains weak. We hypothesized that long-term follow-up of patients with pathologically-proven arterial C. pneumoniae infection might provide further insight into the role of C. pneumoniae in carotid atherosclerosis.Methods:We followed a cohort of 70 carotid endarterectomy patients for ipsilateral restenosis, contralateral progression, and all-cause mortality (four year median follow-up period). All patients had presence or absence of C. pneumoniae in their carotid plaques documented by immunohistochemistry after endarterectomy. A survival function was generated and the log-rank test was used to assess the difference in survival between subjects with and without documented chlamydial infection in their plaque.Results:Baseline demographic and cardiovascular risk factors were similar between the two groups, and survival analysis demonstrated no difference (p>0.05) in all-cause mortality, or all-cause mortality combined with restenosis and progression.Conclusion:Our data finds no causal role for C. pneumoniae in restenosis or progression of carotid disease or mortality in this patient population with advanced carotid atherosclerosis.

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Zakirov, I. R., I. R. Yagafarov, M. G. Khatypov, N. G. Sibagatullin, M. Kh Zakirzyanov, N. G. Faskhutdinov, R. F. Gaysin, A. A. Bikchantaev, M. N. Nadyrova, and D. V. Matveeva. "Long-term results of eversion surgeries for internal carotid artery stenosis due to atherosclerosis." Kazan medical journal 96, no. 3 (June 15, 2015): 337–40. http://dx.doi.org/10.17750/kmj2015-337.

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Aim. Analysis of long-term results of eversion carotid endarterectomy in patients with atherosclerotic carotid stenosis.Methods. 272 eversion carotid endarterectomy surgeries was performed from June 2008 to December 2014 in the department of cardiac surgery. Long-term results were studied in 198 (73%) patients, with follow-up term ranging from 6 to 48 months. The method of operation serves as a criterion separating Patients were allocated into two groups by the surgery method: in the first group, eversion endarterectomy was performed by Kieny, in the second - by DeBakey.Results. Reconstructed ipsilateral internal carotid artery was passable during the follow-up period in 100% of cases, as confirmed by ultrasonography. In the late period, the mortality in the first group was 2.3% (myocardial infarction and cancer), compared to 1.5% in the second group (myocardial infarction). Acute ischemic stroke occurred in 0.8% of the first group patients and in 1.5% of the second group patients. Restenosis of 50 to 69% were discovered in 3.7% of cases in first group and in 3% in the second group. Restenosis ≥70% were found in 1.5% in both groups of patients.Conclusion. The obtained data confirm that both methods of eversion carotid endarterectomy are safe and reliable in treatment of carotid arteries atherosclerosis and, thus, preventing stroke.

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Puglioli, M., R. Padolecchia, P. L. Collavoli, G. Parenti, G. Orlandi, and C. Paoli. "Angioplastica carotidea." Rivista di Neuroradiologia 11, no. 4 (August 1998): 431–42. http://dx.doi.org/10.1177/197140099801100402.

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L'endoarteriectomia, come confermano i risultati degli studi multicentrici NASCET (North American Symptomatic Carotid Endarterectomy Trial), ECST (European Carotid Surgery Trial) ed ACAS (Asymptomatic Carotid Atherosclerosis Study), rappresenta il trattamento di elezione delle stenosi aterosclerotiche interessanti il distretto extracranico dell'arteria carotide, sia nei pazienti sintomatici (stenosi > 70%) che asintomatici (stenosi > 60%). L'intervento chirurgico è gravato da un rischio cumulativo di morbilità-mortalità (stroke/morte) che il NASCET, l'ECST e l'ACAS segnalano, rispettivamente, nel 5,8%, 7,5% e 2,3%, insieme ad altre possibili complicanze: infarto miocardico (0,9%), paralisi di nervi cranici (7,6%), ematoma del collo (5,5%), infezioni (3,4%). Qualora, per ragioni cliniche od anatomiche, il rischio chirurgico sia troppo elevato, come nei pazienti cardiopatici, diabetici, con insufficienza polmonare o renale, con restenosi, con stenosi post-attiniche o fibrodisplastiche, con stenosi carotidee prossimali o distali, con lesioni «tandem», l'angioplastica transluminale percutanea (PTA) e/o lo Stenting carotideo possono rappresentare una valida alternativa terapeutica all'endoarteriectomia. In questo articolo presentiamo la nostra casistica relativa a 41 procedure (36 PTA; 5 Stenting), eseguite su 33 pazienti negli ultimi due anni. I trattamenti sono stati rivolti a 28 arterie carotidi interne, 4 arterie carotidi esterne, 2 arterie carotidi comuni, 2 tronchi anonimi; gli stents sono stati rilasciati in 4 arterie carotidi interne e in 1 arteria carotide comune. Le procedure regolarmente portate a termine sono state 37 (32 PTA; 5 Stents), con un ottimo risultato anatomico in 36 casi. Nei controlli a 6 mesi abbiamo riscontrato una ristenosi (< 60%), asintomatica. In questo articolo illustriamo il nostro protocollo, gli insuccessi tecnici, i risultati e le complicanze.

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Malkoff, Marc D., Linda S. Williams, and Jose Biller. "Advances in Management of Carotid Atherosclerosis." Journal of Intensive Care Medicine 12, no. 2 (March 1997): 55–65. http://dx.doi.org/10.1177/088506669701200201.

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Carotid artery stenosis is a common and potentially treatable cause of stroke. Stroke risk is increased as the degree of carotid stenosis increases, as well as in patients with neurological symptoms referable to the stenosed carotid artery. Carotid stenosis can be quantified by ultrasound imaging, magnetic resonance angiography, or conventional angiography. Medical treatment with platelet antiaggregants reduces stroke risk in some patients; other patients are best treated with carotid endarterectomy. Experimental treatments for carotid stenosis, including carotid angioplasty with or without stenting, are under investigation. We summarize the current literature and provide treatment recommendations for patients with atherosclerotic carotid artery disease.

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Yaşa, Haydar, Övünç Aslan, Barçın Özcem, Muhammet Akyuz, Ali Gürbüz, and Galip Akhan. "An Alternative Surgical Procedure for a Patient with Critically Restenosed and Kinked Carotid Artery: Graft Interposition." Case Reports in Surgery 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/572454.

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According to the literature data, the prevalence of restenosis after carotid endarterectomy ranges between 6 and 36%. The etiological factor is intimal hyperplasia for early period, whereas it is atherosclerosis for late period. A 67-year-old male patient admitted to our clinic with a history of headache and minor stroke. His medical history was significant for right carotid endarterectomy 8 years ago. Recent Doppler ultrasound and digital substraction angiography revealed 75% stenosis and kinking corresponding to the segment distal to the endarterectomy region. Surgical endarterectomy is the treatment of choice in critical carotid stenosis. Endovascular therapy is primarily considered for patients if there is restenosis after carotid endarterectomy. However, the treatment modality is controversial in cases with concomitant carotid stenosis and kinking of internal carotid artery. We present our surgical approach to a case with significant stenosis and kinking of internal carotid artery. We performed a 6-mm-PTFE graft interposition between common and internal carotid artery and resection of the kinking segment.

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Rancic, Zoran, Djordje Radak, and Dragan Stojanovic. "Early detection of asymptomatic carotid disease in patients with arteriosclerotic occlusive disease of the lower extremities." Srpski arhiv za celokupno lekarstvo 130, no. 7-8 (2002): 258–64. http://dx.doi.org/10.2298/sarh0208258r.

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Prevalence of asymptomatic carotid artery stenosis in patients with lower extremities atherosclerosis is relatively high. Limiting screening of specific subgroups for any demographic or medical characteristics is ineffective. Screening for asymptomatic carotid artery stenosis is indicated in all patients with lower extremities atherosclerosis except in whom prophylactic carotid endarterectomy is not recommended because of comorbid disease or extreme age.

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Debing, Erik, Els Peeters, William Duquet, Kris Poppe, Brigitte Velkeniers, and Pierre Van den Brande. "Endogenous sex hormone levels in postmenopausal women undergoing carotid artery endarterectomy." European Journal of Endocrinology 156, no. 6 (June 2007): 687–93. http://dx.doi.org/10.1530/eje-06-0702.

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Objective: To study the endogenous sex hormone levels in natural postmenopausal women and their association with the presence of internal carotid artery (ICA) atherosclerosis. Design: Case-control study Methods: We compared 56 patients with severe ICA atherosclerosis referred for carotid artery endarterectomy (CEA) with 56 age-matched control subjects free of severe atherosclerotic disease. The presence of atherosclerosis was determined by high-resolution B-mode ultrasound. Metabolic parameters and sex hormones were measured or calculated: total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, glucose, insulin, quantitative insulin sensitivity check index, insulin resistance index, IGF-I, DHEA, DHEA sulfate (DHEA-S), free testosterone, total testosterone, estrone, estradiol, androstenedione, and sex hormone-binding globulin. Results: The cases had statistically significant lower levels of both total testosterone (0.23 ± 0.12 vs 0.31 ± 0.20 μg/l, P = 0.043) and free testosterone (3.42 ± 1.94 vs 4.59 ± 2.97 ng/l, P = 0.009) and significantly lower levels of androstenedione (625.3 ± 168.7 vs 697.0 ± 211.9 ng/l, P = 0.017) when compared with controls. Multivariate linear regression analysis, adjusted for traditional cardiovascular risk factors, baseline and physiologic characteristics, showed a significant inverse relationship between both serum free testosterone (β = −0.234, P = 0.028) and androstenedione (β = −0.241, P = 0.028) levels with the presence of severe atherosclerosis of ICA. Conclusions: The study provides evidence of a positive association between low serum androgen levels and severe ICA atherosclerosis in postmenopausal women. It suggests that higher, but physiological, levels of androgens in postmenopausal women have a protective role in the development of atherosclerosis of ICA.

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Benitez, Ronald P., Rocco A. Armonda, James Harrop, Jeffrey E. Thomas, and Robert H. Rosenwasser. "Carotid angioplasty and stenting for recurrent and radiation-induced stenosis: preliminary experience." Neurosurgical Focus 5, no. 4 (October 1998): E16. http://dx.doi.org/10.3171/foc.1998.5.4.17.

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Carotid endarterectomy for atherosclerotic occlusive disease has become the standard of care for the treatment of symptomatic and asymptomatic occlusive disease of the carotid bifurcation, based on the results of the North American Symptomatic Carotid Endarterectomy Trial, as well as the Asymptomatic Carotid Atherosclerosis Study. For surgical treatment to be of benefit, the perioperative complication rate for neurological events should be 6% or less in the symptomatic population and 3% or less in the asymptomatic group. The performance of carotid endarterectomy for recurrent stenosis and radiation-induced stenosis has reported neurological events ranging from 4 to 10%. It is in this particular population that carotid angioplasty and stent placement may play a role. The authors performed a retrospective analysis of 11 patients who underwent carotid angioplasty and stent placement for recurrent or radiation-induced stenosis. One patient in whom endarterectomy was performed by the vascular surgery service had a critical stenosis distal to the endarterectomy site and awoke with a neurological deficit. This patient underwent reexploration and placement of a stent in the artery distal to the arteriotomy site. The follow-up period ranged from 7 to 12 months. Patient age ranged from 65 to 77 years (mean 75 years). Five of eight patients underwent angioplasty and stent placement for recurrent atherosclerotic disease. Two patients had radiation-induced stenosis, and one patient had a stent placed intraoperatively. All patients, with the exception of the one who underwent intraoperative stent placement, had posttreatment stenoses of less than 15%. The surgical patient had a 30% residual stenosis distally. There were no intra- or postoperative transient ischemic attacks, major or minor strokes, or deaths. Patients who have recurrent or radiation-induced stenosis are potential candidates for angioplasty and stent placement. Before this can be recommended as an alternative to surgical correction, a longer follow-up period is required.

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Dissertations / Theses on the topic "Atherosclerosis; Carotid endarterectomy"

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Senaratne, Jawaharlal W. B. "An investigation into genetic and environmental influences on and treatment of end-stage atherosclerotic arterial disease." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365465.

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Fiebig, Marnie. "Chlamydia pneumoniae as an etiological agent in atherosclerosis from patients undergoing carotid endarterectomy or abdominal aortic aneurysm repair." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ55902.pdf.

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Siqueira, Letícia Cristina Dalledone 1981. "Avaliação da resposta hemodinâmica cerebral através da monitorização com a espectroscopia próxima ao infravermelho (NIRS) em pacientes com doença aterosclerótica submetidos à endarterectomia de carótida = Evaluation of the brain hemodynamic response by means of near-infrared spectroscopy (NIRS) monitoring in atherosclerotic patients who underwent carotid endarterectomy." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312479.

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Orientador: Ana Terezinha Guillaumon
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-28T09:17:18Z (GMT). No. of bitstreams: 1 Siqueira_LeticiaCristinaDalledone_M.pdf: 5041737 bytes, checksum: 615b5b4269f2f46490565662d28dfb21 (MD5) Previous issue date: 2015
Resumo: Introdução: A espectroscopia próxima ao infra-vermelho (NIRS) é uma técnica não invasiva e de baixo custo que detecta as alterações hemodinâmicas teciduais. O NIRS pode monitorar de forma contínua as informações fisiológicas vasculares intracranianas. Por ser portátil, ele pode ser utilizado a beira do leito e no centro cirúrgico. Objetivo: Avaliar o comportamento das possíveis alterações hemodinâmicas cerebrais, durante a endarterectomia, em pacientes com estenoses maiores que 70%, utilizando NIRS. Casuística e métodos: Foram avaliados 10 voluntários portadores de doença carotídea aterosclerótica com indicação de endarterectomia. Após a seleção dos pacientes que responderam um questionário com dados epidemiológicos e informações referentes a presença de comorbidades, a doença foi confirmada por métodos diagnósticos. No procedimento cirúrgico utilizou-se o NIRS para monitorização. Foram avaliadas as variáveis saturação de oxigênio (Sat O2) hemoglobina total (HbT), hemoglobina reduzida (HbR) e hemoglobina oxigenada (HbO) nos três tempos cirúrgicos pré, trans e pós-clampeamento carotídeo. Resultados: Utilizou-se p<0,05 como nivel de significância. A avaliação dos resultados obtidos através das medidas registradas pelo NIRS permite afirmar que as etapas da cirurgia diferem quanto ás variável HbR e SatO2. Durante a etapa do clampeamento, a variável HbR mostra valores mais elevados que nas outras duas etapas da cirurgia. De outra parte, a variável SatO2 mostra redução durante o clampeamento. Conclusão: O NIRS é um método viável e aplicável de monitorização intracerebral, não-invasivo e em tempo real, durante a endarterectomia carotídea, capaz de medir de forma precisa as mudanças das condições hemodinâmicas capilares intra-cerebrais
Abstract: Introduction: Near-infrared spectroscopy (NIRS) is a low-cost, non-invasive technique that detects tissue hemodynamic alterations. It enables continuous monitoring of the intracerebral vascular physiologic information. Due to its portable nature, NIRS may be used beside a bed or in the operating room. Objective: To evaluate the use of NIRS for intra-surgical monitoring of the brain hemodynamic response, during an endarterectomy procedure of the atherosclerotic carotid artery. Casuistry and Methods: 10 patients with atherosclerotic carotid disease and recommended endarterectomy were evaluated. They were identified in a survey which provided epidemiologic data and the presence of comorbidities. Disease was confirmed by diagnostic methods. NRIS monitoring was used during the surgical procedure. Oxygen saturation (O2 Sat), total hemoglobin (THb), reduced hemoglobin (RHb), and oxyhemoglobin (OHb) were the variables analyzed at the three carotid clamp stages: pre-, trans- and post-. Results: A p<0.05 value was considered statistically significant. The results obtained from the NIRS data reveal that the surgical stages differ in relation to the RHb and O2Sat variables. RHb presents higher levels during clamping when compared with the other two surgical stages. On the other hand, O2Sat is decreased during clamping. Conclusion: NIRS is a feasible, realtime and non-invasive intracranial monitoring method, during carotid endarterectomy, which measures accurately and reliably the changes of the intracerebral capillary hemodynamic conditions
Mestrado
Cirurgia
Mestra em Ciências

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Kretz, Benjamin. "Sténoses carotidiennes athéromateuses : causes fondamentales et conséquences cliniques." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOMU04/document.

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Le traitement de référence des lésions sténosantes carotidiennes de haut grade est la chirurgie associée à un traitement médical. Nous avons mis en place depuis 2003 une base de données prospective colligeant l’ensemble des patients hospitalisés dans notre service pour prise en charge d’une lésion sténosante carotidienne d’indication chirurgicale. Depuis 2012, cette base de données cliniques s’est vue complétée par la mise en place d’une tissuthèque et d’une plasmathèque. Nous présentons ici la méthode de mise en place d’une telle base, puis les résultats de quatre études originales sur la thématique du « patient à risque » en chirurgie carotidienne, portant sur l’influence de la fonction rénale, du délai entre les symptômes et la chirurgie et du statut de l’artère carotide controlatérale sur les résultats de cette chirurgie, ainsi que la proposition d’un score pronostic d’intolérance au clampage carotidien. Nous avons montré que l’insuffisance rénale influait sur les résultats de la chirurgie carotidienne de manière différente en fonction de la méthode d’appréciation de la fonction rénale (créatinine plasmatique, clearance de la créatinine calculée selon Cockcroft-Gault ou selon la formule MDRD) ; que le statut hémodynamique de la carotide controlatérale influait sur le taux de shunt sans modifier la morbidité ; que la chirurgie précoce des sténoses carotidiennes symptomatiques n’était pas grevée d’une surmortalité ; et qu’il était possible dans une certaine mesure de prédire la nécessité de mise en place d’un shunt carotidien. Nous abordons enfin les projets à venir utilisant la collection biologique pour tenter d’identifier les plaques athéromateuses à risque
The treatment of high-grade carotid stenosis is surgery combined with best medical treatment. We established since 2003, a prospective database including all patients hospitalized in our vascular surgery department for management of carotid stenosis. Since 2012, the clinical database was completed for the establishment of a biological database. We present here the method of setting up such a database, and the results of four original studies on the theme of "high-risk patient" for carotid surgery: the influence of renal function, of the delay between symptoms and surgery and of the contralateral carotid artery on outcome and the proposal of a prognostic score of intolerance to carotid clamping. We have shown that renal failure influenced outcome of carotid surgery in different ways depending on the method of assessment of renal function (serum creatinine, creatinine clearance calculated by Cockcroft-Gault or MDRD formula) ; the hemodynamic status of the contralateral carotid affected the rate of shunt without changing morbidity; that early surgery for symptomatic carotid stenosis was not burdened with excess mortality; and that it is possible to predict the need for establishment of a carotid shunt. Finally, we discuss future projects using biological collection to try to identify atherosclerotic plaques at risk

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Kuster, Gustavo Wruck. "Tomografia computadorizada de placa carotídea: uma comparação com a histologia." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12012016-084705/.

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As características morfológicas da placa aterosclerótica têm sido sugeridas como componentes auxiliares à estenose, na avaliação de risco de acidente vascular cerebral (AVC), em pacientes com doença aterosclerótica carotídea sintomática. O objetivo desse estudo foi comparar as características da placa aterosclerótica de carótida pelo método de tomografia computadorizada com a análise histológica. Foram incluídos 19 pacientes com doença carotídea sintomática submetidos à TC de placa carotídea antes da realização de endarterectomia carotídea. Uma comparação sistemática entre a TC e a histologia foi realizada para determinar a correspondência entre os componentes da placa seguindo a classificação da \"American Heart Association\". Foi considerada placa vulnerável o tipo VI. A histologia foi realizada 5 (±2) dias após a TC. Os laudos (radiologia e patologia) foram comparados pelo investigador principal. Foi dosada a proteína C-Reativa (PCR) sérica e realizada avaliação do desempenho do PCR para detectar placa vulnerável, considerando como padrão-ouro o resultado da avaliação histológica. Foi avaliada a relação entre PCR e o tempo entre o evento e a cirurgia. Para tipo de placa aterosclerótica, foi encontrada uma acurácia de 84,2% (IC 95%: 82,8% a 85,6%), da tomografia em relação à histologia. A concordância para identificar ruptura de capa fibrosa com acurácia 94,7% (IC 95%: 94,2% a 95,3%), e, para calcificação, com acurácia 89.5% (IC 95%: 88,5% a 90,5%), foi considerada alta, e moderada para identificar hemorragia (68% acurácia). A concordância é moderada entre PCR de alto risco e placa vulnerável, e não há relação entre PCR, placa vulnerável e tempo de cirurgia. A tomografia de placa carotídea é um bom método não invasivo para detecção de vulnerabilidade da placa, identificação de ruptura de capa fibrosa e calcificação. Na nossa amostra, a concordância entre PCR alto risco e vulnerabilidade foi moderada, e não observamos relação entre vulnerabilidade, PCR e tempo entre o evento e a endarterectomia
Plaque morphologic characteristics have been suggested as an auxiliary component to luminal narrowing for assessing the risk of stroke associated with carotid atherosclerotic disease (CAD). The purpose of this study was to evaluate the ability of CT angiography (CTA) to categorize carotid artery atherosclerotic plaques (CAP) features in symptomatic patients submitted to endarterectomy according to the AHA histological classification. Nineteen patients with symptomatic CAD who underwent carotid CTA before endarterectomy were enrolled in a prospective study. A systematic comparison of CTA images with histological sections was performed to determine the CT attenuation associated with each component of the CAP. Histologic examination was performed 5 ± 2 days after the CTA. The neuroradiologist\'s reading of these analyses was compared with the histological slides interpretation performed by the same pathologist according to the CAP features following the AHA classification. The type VI plaque was considered as complicated. The two experts were blinded to each other\"s assessments. We performed C reactive Protein (CRP) and the CRP capacity to detect plaque vulnerability, considering histologic features as gold standard and the relation between CRP and time (event-surgery). There was an overall 84.2% (CI 95%: 82.8% a 85.6%), accuracy agreement in CAP classification between CTA and histological analysis. (Tab.1) The agreement between these two methods for the presence of calcification (Tab.2) in the CAP (accuracy 89.5%), and for categorizing the rupture of fibrous cap (accuracy 94,7), was excellent. (Tab. 3). CTA is not a good method to detect hemorrhage (Tab.4). High-risk CRP had moderate power to predict \"complicated plaque\" (Tab. 4) even as high risk CRP + CTA (Tab.5), There are No relation between CRP, complicated plaque and event to surgery delay. (Tab.6) CTA is a non-invasive tool that may help neurologists to categorize CAP features and potentially predict the risk of ischemic stroke in symptomatic CAD patients, and CRP could not be a good marker to complicated carotid plaque

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Books on the topic "Atherosclerosis; Carotid endarterectomy"

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Ellis, Jason A., and E. Sander Connolly. Vascular Biology of Cerebral Ischemia. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0107.

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Carotid stenosis may be treated by carotid endarterectomy (CEA) or carotid artery stenting (CAS). Moderate asymptomatic carotid stenosis (50%-70%) is associated with a low risk of ischemic stroke and does not warrant treatment. The severe stenosis (>70%) population sees a marginal benefit in seen with CEA. In the Asymptomatic Carotid Atherosclerosis Study, authors concluded that for patients with less than 60% stenosis, a 5.9% absolute risk reduction was obtained over 5 years with CEA compared with maximum medical management (11 vs. 5.1%).

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Book chapters on the topic "Atherosclerosis; Carotid endarterectomy"

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D’Addato, M., and L. Pedrini. "Results of carotid endarterectomy." In Atherosclerosis and Cardiovascular Diseases, 309–15. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_40.

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Nessi, Franco, Michelangelo Ferri, Emanuele Ferrero, and Andrea Viazzo. "Treatment of Carotid Stenosis: Carotid Endarterectomy and Carotid Angioplasty and Stenting." In Atherosclerosis Disease Management, 529–62. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-7222-4_18.

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Weber, G., D. Bertini, G. Bianciardi, L. Centi, L. Moggi, M. T. Novelli, G. Nuzzaci, et al. "Comparative evaluation of echographic and histomorphometric data of carotid endarterectomy samples." In Atherosclerosis and Cardiovascular Diseases, 327–30. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_42.

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Townsend, Robert K., Kyle M. Fargen, Jasmeet Singh, John A. Wilson, and Stacey Q. Wolfe. "Carotid Artery Stenting Versus Endarterectomy for Atherosclerosis: An Evidence-Based Review." In Management of Cerebrovascular Disorders, 399–410. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-99016-3_25.

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Hans, Sachinder Singh. "Redo Carotid Endarterectomy for Recurrent Atherosclerotic Carotid Stenosis." In Challenging Arterial Reconstructions, 177–79. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44135-7_42.

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Tanganelli, P., G. Bianciardi, M. Salvi, V. Attino, C. Simōes, G. Weber, U. Senin, et al. "Ultrasonographic and Histomorphometric Evaluation of Endarterectomy Samples from Carotid Lesions: New Perspectives in Qualitative Evaluation of B-Mode Ultrasound Images." In Atherosclerotic Plaques, 39–46. New York, NY: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-0438-9_5.

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"66 Anatomic Variant-Atherosclerotic Web on Posterior Wall of Vessel." In Carotid Endarterectomy, 250–51. CRC Press, 2006. http://dx.doi.org/10.3109/9781420016277-92.

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"Registries and Trials of Carotid Artery Stenting Versus Carotid Endarterectomy Elad I Levy, Ricardo A Hanel and L Nelson Hopkins." In Carotid Atherosclerotic Disease, 276–84. CRC Press, 2008. http://dx.doi.org/10.3109/9780203091548-21.

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Conference papers on the topic "Atherosclerosis; Carotid endarterectomy"

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Абиева, А. Р., Н. А. Дарвиш, А. А. Тяжельников, and Л. И. Пышкина. "Clinical neurological features in those who underwent carotid endarterectomy and unoperated patients with cerebral atherosclerosis." In Научный диалог: Вопросы медицины. ЦНК МОАН, 2018. http://dx.doi.org/10.18411/spc-15-04-2018-01.

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Boekhoven, Renate W., Marcel C. M. Rutten, Marc R. H. M. van Sambeek, and Frans N. van de Vosse. "In Vitro Three Dimensional Imaging of Human Carotid Atherosclerotic Plaques Using Ultrasonography." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53463.

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Ruptured atherosclerotic plaques in the carotid artery are the main cause of stroke (70–80%). To prevent it, carotid endarterectomy is the procedure of choice in patients with a recent symptomatic 70–99% stenosis. Today, the selection of candidates is based on stenosis size only. However, endarterectomy is beneficial for only 1 out of 6 patients [1], the patients with unstable plaques (Fig. 1). Knowledge of mechanical properties of different components in the atherosclerotic arteries is important, because it will allow the identification of plaque stability at an early stage.

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Boekhoven, Renate W., Richard G. P. Lopata, Marcel C. M. Rutten, Marc R. H. M. van Sambeek, and Frans N. van de Vosse. "Novel Strategy of the Determination of Mechanical Properties of Human Carotid Atherosclerotic Plaques." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80669.

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Carotid endarterectomy is the procedure of choice in patients with a recent symptomatic stenosis of 70–99%. Currently, the selection of candidates eligible for carotid endarterectomy is based on stenosis size only. However, the treatment is only beneficial for patients with unstable plaques, which comprises only 16% of the patient population [1]. Hence, identifying plaque stability at an early stage would permit timely intervention, while substantially reducing overtreatment of stable plaques. The objective of this study is to distinguish between stable and unstable carotid atherosclerotic plaques by determining the plaque geometry, the plaque composition and the mechanical properties of plaque components in three dimensions (3D). Mechanical properties from healthy vessels were assessed earlier by van den Broek et al. [2] using ultrasound (US) imaging. They obtained a dynamic dataset in 2D + t. When blood pressure and vessel wall movement are known, mechanical properties can be extracted from these data using a constitutive model. However, atherosclerotic plaques are mostly asymmetric, and present calcifications will cause unfavorable acoustic shadowing when using US. In this study, the focus is on the assessment of plaque geometry, from in vitro echo-CT data, overcoming the aforementioned problems. In an experimental set-up (Fig. 1) both healthy and endarterectomy specimens were mounted, and exposed to physiological intraluminal pressures. Echo-CT was used to image the arterial segments in 3D+t. Automated geometry assessment of the arterial segments will be demonstrated and validated using microCT (μCT).

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Maher, Eoghan, Arthur Creane, Sherif Sultan, Niamh Hynes, Caitríona Lally, and Daniel J. Kelly. "Mechanical Characterization of Fresh Human Carotid Atherosclerotic Plaque." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206271.

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Quantifying the properties of atherosclerotic plaques is critical to improving our understanding of the pathogenesis of the disease. Furthermore realistic tissue properties are vital in order to obtain legitimate results from finite element models of surgical interventions used to treat cardiovascular disease. The aim of this study is to determine the mechanical properties of fresh human carotid plaques immediately following removal during endarterectomy. A number of studies have reported atherosclerotic plaque properties previously [1–3], however all of these tested cadaveric tissue. This study will further investigate in-patient and inter-patient variability, the relationship between plaque properties and their clinical classification (calcified, mixed or echolucent) and the location of the sample (common, internal, external carotid).

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Teng, Zhongzhao, Umar Sadat, and Jonathan H. Gillard. "Stress-Strain Profile of Carotid Plaque With and Without Juxtaluminal Hemorrhage/Thrombus: A Possible Mechanism for Subsequent Cerebrovascular Events." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53078.

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Patients suffering from a transient ischemic attack (TIA) are at high risk of a stroke or recurrent TIA, with about half of all recurrent events during the seven days after a TIA occurring in the first 24 hours. These events are usually caused by thromboembolization from ruptured carotid atherosclerotic plaques. Large trials have shown that carotid endarterectomy benefits patients with high grade carotid stenosis, but the risk-to-benefit ratio was less clear-cut for symptomatic patients with moderate stenosis (50–69%). Therefore, identification of high-risk plaques within this group could significantly decrease the ratio.

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Boekhoven, Renate W., Marcel C. M. Rutten, Marc R. H. M. van Sambeek, Frans N. van de Vosse, and Richard G. P. Lopata. "Geometrical and Morphological Assessment of Human Endarterectomy Specimens In Vitro." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14297.

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Treatment of rupture-prone carotid atherosclerotic plaques, by means of endarterectomy, is only beneficial for patients with unstable plaques, which comprise only 16% of the patient population [1]. It is therefore of great interest to assess morphology, geometry and mechanical deformation of the plaque and its components, to prevent unnecessary treatment. However, due to the complex geometry of stenotic arteries, 3D information at both high temporal and spatial resolution is required. Besides, assessment of plaque morphology in vivo can still not be routinely performed. Therefore, one has to rely on in vitro methods to obtain morphology and mechanical properties, and thus rupture risk.

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