Journal articles on the topic 'Ataxia Telangiectasia and Rad3-related (ATR)'
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Friesner, Joanna D., Bo Liu, Kevin Culligan, and Anne B. Britt. "Ionizing Radiation–dependent γ-H2AX Focus Formation Requires Ataxia Telangiectasia Mutated and Ataxia Telangiectasia Mutated and Rad3-related." Molecular Biology of the Cell 16, no. 5 (May 2005): 2566–76. http://dx.doi.org/10.1091/mbc.e04-10-0890.
Full textKumbhar, Ramhari, Sophie Vidal-Eychenié, Dimitrios-Georgios Kontopoulos, Marion Larroque, Christian Larroque, Jihane Basbous, Sofia Kossida, Cyril Ribeyre, and Angelos Constantinou. "Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling." Life Science Alliance 1, no. 3 (June 2018): e201800096. http://dx.doi.org/10.26508/lsa.201800096.
Full textTurner, Thomas, and Thomas Caspari. "When heat casts a spell on the DNA damage checkpoints." Open Biology 4, no. 3 (March 2014): 140008. http://dx.doi.org/10.1098/rsob.140008.
Full textDeHart, Jason L., Joshua L. Andersen, Erik S. Zimmerman, Orly Ardon, Dong Sung An, Jana Blackett, Baek Kim, and Vicente Planelles. "The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration." Journal of Virology 79, no. 3 (February 1, 2005): 1389–96. http://dx.doi.org/10.1128/jvi.79.3.1389-1396.2005.
Full textVidal-Eychenié, Sophie, Chantal Décaillet, Jihane Basbous, and Angelos Constantinou. "DNA structure-specific priming of ATR activation by DNA-PKcs." Journal of Cell Biology 202, no. 3 (July 29, 2013): 421–29. http://dx.doi.org/10.1083/jcb.201304139.
Full textAsmal, M., E. Dean, J. Evans, M. Middleton, and R. Plummer. "VX-970, selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein." Annals of Oncology 26 (March 2015): ii8. http://dx.doi.org/10.1093/annonc/mdv084.4.
Full textTakeuchi, Makoto, Michihiro Tanikawa, Kazunori Nagasaka, Katsutoshi Oda, Yoshiko Kawata, Shinya Oki, Chuwa Agapiti, et al. "Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells." Cancers 11, no. 12 (December 1, 2019): 1913. http://dx.doi.org/10.3390/cancers11121913.
Full textWard, Irene M., Kay Minn, and Junjie Chen. "UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress." Journal of Biological Chemistry 279, no. 11 (January 23, 2004): 9677–80. http://dx.doi.org/10.1074/jbc.c300554200.
Full textTibelius, Alexandra, Joachim Marhold, Hanswalter Zentgraf, Christoph E. Heilig, Heidemarie Neitzel, Bernard Ducommun, Anita Rauch, Anthony D. Ho, Jiri Bartek, and Alwin Krämer. "Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1." Journal of Cell Biology 185, no. 7 (June 22, 2009): 1149–57. http://dx.doi.org/10.1083/jcb.200810159.
Full textPancholi, Neha J., Alexander M. Price, and Matthew D. Weitzman. "Take your PIKK: tumour viruses and DNA damage response pathways." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1732 (September 11, 2017): 20160269. http://dx.doi.org/10.1098/rstb.2016.0269.
Full textPan-Hammarström, Qiang, Aleksi Lähdesmäki, Yaofeng Zhao, Likun Du, Zhihui Zhao, Sicheng Wen, Victor L. Ruiz-Perez, Deborah K. Dunn-Walters, Judith A. Goodship, and Lennart Hammarström. "Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation." Journal of Experimental Medicine 203, no. 1 (January 3, 2006): 99–110. http://dx.doi.org/10.1084/jem.20050595.
Full textMüller, Berndt, Jane Blackburn, Carmen Feijoo, Xiujie Zhao, and Carl Smythe. "DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication." Journal of Cell Biology 179, no. 7 (December 24, 2007): 1385–98. http://dx.doi.org/10.1083/jcb.200708106.
Full textLuo, Ying, and Shiyuan Hong. "The Role of Ataxia Telangiectasia Mutant and Rad3-Related DNA Damage Response in Pathogenesis of Human Papillomavirus." Pathogens 9, no. 6 (June 23, 2020): 506. http://dx.doi.org/10.3390/pathogens9060506.
Full textMartínez, Paula, Juana M. Flores, and Maria A. Blasco. "53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response." Journal of Cell Biology 197, no. 2 (April 16, 2012): 283–300. http://dx.doi.org/10.1083/jcb.201110124.
Full textDiernfellner, Axel C. R., Linda Lauinger, Anton Shostak, and Michael Brunner. "A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa." Proceedings of the National Academy of Sciences 116, no. 35 (August 14, 2019): 17271–79. http://dx.doi.org/10.1073/pnas.1815396116.
Full textLi, Siyu, Tao Wang, Xichang Fei, and Mingjun Zhang. "ATR Inhibitors in Platinum-Resistant Ovarian Cancer." Cancers 14, no. 23 (November 29, 2022): 5902. http://dx.doi.org/10.3390/cancers14235902.
Full textRamachandran, Sreekanth A., Pradeep S. Jadhavar, Manvendra P. Singh, Ankesh Sharma, Gaurav N. Bagle, Kevin P. Quinn, Po-yin Wong, et al. "Discovery of pyrazolopyrimidine derivatives as novel inhibitors of ataxia telangiectasia and rad3 related protein (ATR)." Bioorganic & Medicinal Chemistry Letters 27, no. 4 (February 2017): 750–54. http://dx.doi.org/10.1016/j.bmcl.2017.01.045.
Full textRoitinger, Elisabeth, Manuel Hofer, Thomas Köcher, Peter Pichler, Maria Novatchkova, Jianhua Yang, Peter Schlögelhofer, and Karl Mechtler. "Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response inArabidopsis thaliana." Molecular & Cellular Proteomics 14, no. 3 (January 5, 2015): 556–71. http://dx.doi.org/10.1074/mcp.m114.040352.
Full textSavva, Constantinos, Karen De Souza, Reem Ali, Emad A. Rakha, Andrew R. Green, and Srinivasan Madhusudan. "Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers." Breast Cancer Research and Treatment 175, no. 1 (February 12, 2019): 105–15. http://dx.doi.org/10.1007/s10549-018-05113-8.
Full textIsono, Makoto, Kazuki Okubo, Takako Asano, and Akinori Sato. "Ataxia telangiectasia and Rad3-related inhibition by AZD6738 enhances gemcitabine-induced cytotoxic effects in bladder cancer cells." PLOS ONE 17, no. 4 (April 12, 2022): e0266476. http://dx.doi.org/10.1371/journal.pone.0266476.
Full textMontales, Katrina, Kenna Ruis, Howard Lindsay, and W. Matthew Michael. "MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks." PLOS ONE 17, no. 8 (August 2, 2022): e0271905. http://dx.doi.org/10.1371/journal.pone.0271905.
Full textKabeche, Lilian, Hai Dang Nguyen, Rémi Buisson, and Lee Zou. "A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation." Science 359, no. 6371 (November 23, 2017): 108–14. http://dx.doi.org/10.1126/science.aan6490.
Full textKang, Tae-Hong. "Circadian Rhythm of NER and ATR Pathways." Biomolecules 11, no. 5 (May 11, 2021): 715. http://dx.doi.org/10.3390/biom11050715.
Full textGusho, Elona, and Laimonis Laimins. "Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection." Viruses 13, no. 7 (July 17, 2021): 1390. http://dx.doi.org/10.3390/v13071390.
Full textWang, Li-Wei, Songwei Jiang, Ying-Hui Yuan, Jilong Duan, Nian-Dong Mao, Zi Hui, Renren Bai, Tian Xie, and Xiang-Yang Ye. "Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR)." Molecules 27, no. 8 (April 12, 2022): 2491. http://dx.doi.org/10.3390/molecules27082491.
Full textKim, Jung-Ae, Michael Kruhlak, Farokh Dotiwala, André Nussenzweig, and James E. Haber. "Heterochromatin is refractory to γ-H2AX modification in yeast and mammals." Journal of Cell Biology 178, no. 2 (July 16, 2007): 209–18. http://dx.doi.org/10.1083/jcb.200612031.
Full textMa, Shuai, Cheng Cao, Shiyou Che, Yuejiao Wang, Dongxue Su, Shuai Liu, Wenchen Gong, et al. "PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability." Science Advances 7, no. 19 (May 2021): eabf7684. http://dx.doi.org/10.1126/sciadv.abf7684.
Full textNgoi, Natalie Y. L., Guang Peng, and Timothy A. Yap. "A Tale of Two Checkpoints: ATR Inhibition and PD-(L)1 Blockade." Annual Review of Medicine 73, no. 1 (January 27, 2022): 231–50. http://dx.doi.org/10.1146/annurev-med-042320-025136.
Full textBothou, Christina, Ashish Sharma, Adrian Oo, Baek Kim, Pal Perge, Peter Igaz, Cristina L. Ronchi, Igor Shapiro, and Constanze Hantel. "Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment." Cancers 13, no. 16 (August 20, 2021): 4200. http://dx.doi.org/10.3390/cancers13164200.
Full textLu, Huiming, Janapriya Saha, Pauline J. Beckmann, Eric A. Hendrickson, and Anthony J. Davis. "DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response." Nucleic Acids Research 47, no. 18 (August 9, 2019): 9467–79. http://dx.doi.org/10.1093/nar/gkz694.
Full textGöhler, Thomas, Simone Sabbioneda, Catherine M. Green, and Alan R. Lehmann. "ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage." Journal of Cell Biology 192, no. 2 (January 17, 2011): 219–27. http://dx.doi.org/10.1083/jcb.201008076.
Full textLi, Pengcheng, Chenchen Xu, Xiaoyan Zhang, Cheng Cao, Xuejuan Wang, and Gang Cai. "Single-stranded RNA viruses activate and hijack host apical DNA damage response kinases for efficient viral replication." Genome Instability & Disease 3, no. 2 (February 28, 2022): 83–87. http://dx.doi.org/10.1007/s42764-022-00064-3.
Full textXiao, Gu, Pao Kue, Rahul Bhosle, and Jill Bargonetti. "Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction." Cell Cycle 14, no. 5 (March 4, 2015): 744–54. http://dx.doi.org/10.1080/15384101.2014.997517.
Full textNam, Edward A., Runxiang Zhao, Gloria G. Glick, Carol E. Bansbach, David B. Friedman, and David Cortez. "Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase." Journal of Biological Chemistry 286, no. 33 (June 24, 2011): 28707–14. http://dx.doi.org/10.1074/jbc.m111.248914.
Full textAbdel-Hafiz, Ahmed, Krishna Madhavan, Ilango Balakrishnan, Angela Pierce, Dong Wang, Etienne Danis, Natalie Serkova, Sujatha Venkataraman, and Rajeev Vibhakar. "MBRS-71. ATAXIA TELANGIECTASIA AND RAD3-RELATED PROTEIN ATTENUATES DNA DAMAGE AND IS A THERAPEUTIC TARGET IN Myc-DRIVEN MEDULLOBLASTOMA." Neuro-Oncology 22, Supplement_3 (December 1, 2020): iii411. http://dx.doi.org/10.1093/neuonc/noaa222.575.
Full textJette, Nicholas R., Mehul Kumar, Suraj Radhamani, Greydon Arthur, Siddhartha Goutam, Steven Yip, Michael Kolinsky, Gareth J. Williams, Pinaki Bose, and Susan P. Lees-Miller. "ATM-Deficient Cancers Provide New Opportunities for Precision Oncology." Cancers 12, no. 3 (March 14, 2020): 687. http://dx.doi.org/10.3390/cancers12030687.
Full textSouthgate, Harriet E. D., Lindi Chen, Deborah A. Tweddle, and Nicola J. Curtin. "ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms." Cancers 12, no. 5 (April 28, 2020): 1095. http://dx.doi.org/10.3390/cancers12051095.
Full textde Lange, Titia. "Shelterin-Mediated Telomere Protection." Annual Review of Genetics 52, no. 1 (November 23, 2018): 223–47. http://dx.doi.org/10.1146/annurev-genet-032918-021921.
Full textKulkarni, Amit, and Kumuda C. Das. "Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation." American Journal of Physiology-Lung Cellular and Molecular Physiology 294, no. 5 (May 2008): L998—L1006. http://dx.doi.org/10.1152/ajplung.00004.2008.
Full textSaldivar, Joshua C., Stephan Hamperl, Michael J. Bocek, Mingyu Chung, Thomas E. Bass, Fernanda Cisneros-Soberanis, Kumiko Samejima, et al. "An intrinsic S/G2 checkpoint enforced by ATR." Science 361, no. 6404 (August 23, 2018): 806–10. http://dx.doi.org/10.1126/science.aap9346.
Full textRozpędek, Wioletta, Dariusz Pytel, Alicja Nowak-Zduńczyk, Dawid Lewko, Radosław Wojtczak, J. Alan Diehl, and Ireneusz Majsterek. "Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment." Current Medicinal Chemistry 26, no. 8 (May 16, 2019): 1425–45. http://dx.doi.org/10.2174/0929867325666180117102233.
Full textWong, Wen-Kyle, Francisco D. C. Guerra Liberal, and Stephen J. McMahon. "DNA Repair Inhibitors Potentiate Fractionated Radiotherapy More Than Single-Dose Radiotherapy in Breast Cancer Cells." Cancers 14, no. 15 (August 4, 2022): 3794. http://dx.doi.org/10.3390/cancers14153794.
Full textLee, Alan Yueh-Luen, Takuya Chiba, Lan N. Truong, An Ning Cheng, Johnny Do, Michael Jeffrey Cho, Longchuan Chen, and Xiaohua Wu. "Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint." Journal of Biological Chemistry 287, no. 4 (November 28, 2011): 2531–43. http://dx.doi.org/10.1074/jbc.m111.291104.
Full textDok, Rüveyda, Mary Glorieux, Marieke Bamps, and Sandra Nuyts. "Effect of ATR Inhibition in RT Response of HPV-Negative and HPV-Positive Head and Neck Cancers." International Journal of Molecular Sciences 22, no. 4 (February 3, 2021): 1504. http://dx.doi.org/10.3390/ijms22041504.
Full textLindsey-Boltz, Laura A., and Aziz Sancar. "Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)." Journal of Biological Chemistry 286, no. 22 (April 18, 2011): 19229–36. http://dx.doi.org/10.1074/jbc.m111.237958.
Full textNam, Edward A., and David Cortez. "ATR signalling: more than meeting at the fork." Biochemical Journal 436, no. 3 (May 27, 2011): 527–36. http://dx.doi.org/10.1042/bj20102162.
Full textO'Driscoll, Mark, Victor L. Ruiz-Perez, C. Geoffrey Woods, Penny A. Jeggo, and Judith A. Goodship. "A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome." Nature Genetics 33, no. 4 (March 17, 2003): 497–501. http://dx.doi.org/10.1038/ng1129.
Full textBiskup, Edyta, David Gram Naym, and Robert Gniadecki. "Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation." Journal of Dermatological Science 84, no. 3 (December 2016): 239–47. http://dx.doi.org/10.1016/j.jdermsci.2016.09.010.
Full textAl-Subhi, Nouf, Reem Ali, Tarek Abdel-Fatah, Paul M. Moseley, Stephen Y. T. Chan, Andrew R. Green, Ian O. Ellis, Emad A. Rakha, and Srinivasan Madhusudan. "Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy." Breast Cancer Research and Treatment 169, no. 2 (February 2, 2018): 277–86. http://dx.doi.org/10.1007/s10549-018-4683-4.
Full textZhang, Jennifer Q. J., Sayanthooran Saravanabavan, and Gopala K. Rangan. "Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease." Cells 10, no. 3 (March 3, 2021): 532. http://dx.doi.org/10.3390/cells10030532.
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