Academic literature on the topic 'Asynchronous replication'

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Journal articles on the topic "Asynchronous replication"

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Natanzon, Assaf, and Eitan Bachmat. "Dynamic Synchronous/Asynchronous Replication." ACM Transactions on Storage 9, no. 3 (August 1, 2013): 1–19. http://dx.doi.org/10.1145/2501620.2508011.

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Natanzon, Assaf, and Eitan Bachmat. "Dynamic Synchronous/Asynchronous Replication." ACM Transactions on Storage 9, no. 3 (August 2013): 1–19. http://dx.doi.org/10.1145/2508011.

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Lee, Jia, Susumu Adachi, and Ferdinand Peper. "Reliable Self-Replicating Machines in Asynchronous Cellular Automata." Artificial Life 13, no. 4 (October 2007): 397–413. http://dx.doi.org/10.1162/artl.2007.13.4.397.

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We propose a self-replicating machine that is embedded in a two-dimensional asynchronous cellular automaton with von Neumann neighborhood. The machine dynamically encodes its shape into description signals, and despite the randomness of cell updating, it is able to successfully construct copies of itself according to the description signals. Self-replication on asynchronously updated cellular automata may find application in nanocomputers, where reconfigurability is an essential property, since it allows avoidance of defective parts and simplifies programming of such computers.
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Mikhailova, G. F., V. V. Tsepenko, T. G. Shkavrova, and E. V. Goloub. "Asynchronous replication in oncological patients." Advances in molecular oncology 5, no. 1 (May 14, 2018): 26–34. http://dx.doi.org/10.17650/2313-805x-2018-5-1-26-34.

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Ogura, Yoshitoshi, Naotake Ogasawara, Elizabeth J. Harry, and Shigeki Moriya. "Increasing the Ratio of Soj to Spo0J Promotes Replication Initiation in Bacillus subtilis." Journal of Bacteriology 185, no. 21 (November 1, 2003): 6316–24. http://dx.doi.org/10.1128/jb.185.21.6316-6324.2003.

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ABSTRACT The ParA and ParB protein families are well conserved in bacteria. However, their functions are still unclear. In Bacillus subtilis, Soj and Spo0J are members of these two protein families, respectively. A previous report revealed that replication initiated early and asynchronously in spo0J null mutant cells, as determined by flow cytometry. In this study, we examined the cause of this promotion of replication initiation. Deletion of both the soj and spo0J genes restored the frequency of replication initiation to almost the wild-type level, suggesting that production of Soj in the absence of Spo0J leads to early and asynchronous initiation of replication. Consistent with this suggestion, overproduction of Soj in wild-type cells had the same effect on replication initiation as in the spo0J null mutant, and overproduction of both Soj and Spo0J did not. These results indicate that when the ratio of Soj to Spo0J increases, Soj interferes with tight control of replication initiation and causes early and asynchronous initiation. Whereas replication initiation also occurred significantly earlier in the two spo0J mutants, spo0J14 and spo0J17, it occurred only slightly early in the sojK16Q mutant and was delayed in the sojG12V mutant. Although Soj localized to nucleoids in the spo0J mutants, the two Soj mutant proteins were distributed throughout the cell or localized to cell poles. Thus, interestingly, the promotion of replication initiation seems to correlate with localization of Soj to nucleoids. This may suggest that Soj inhibits transcription of some cell cycle genes and leads to early and asynchronous initiation of replication. In wild-type cells Spo0J counteracts this Soj function.
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Argyriou-Tirita, A., K. Romanakis, P. Kroisel, and O. A. Haas. "Asynchronous Replication Patterns of Imprinted Genes in Triploid Cells." Acta geneticae medicae et gemellologiae: twin research 45, no. 1-2 (April 1996): 207–12. http://dx.doi.org/10.1017/s0001566000001318.

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Several unique features distinguish imprinted from nonimprinted genes, including the unusual replication behavior the unequal methylation and the differential expression of imprinted alleles [1]. The replication timing in S phase of the two homologous alleles of a normal, nonimprinted gene is highly synchronous [2, 3]. Housekeeping genes replicate early, constitutive heterochromatic regions replicate late and tissue-specific genes replicate earlier when they are expressed than when they are not [2-4]. In contrast, imprinted genes which, by definition, display allele-specific expression replicate asynchronously [2-5].The relative order of replication of homologous alleles as well as that of different loci can be elegantly compared with fluorescence in situ hybridization (FISH) on interphase nuclei [2-5]. Unreplicated DNA segments give singlet hybridization signals in normal diploid cells, while replicated loci are characterized by doublets. The distribution of these two patterns can be used to determine the S phase replication time of any DNA sequence. Moreover, determination of the singlet/doublet ratio allows a good estimation of the degree of replication asynchrony of two homologous alleles [2-5].Using cell lines with deletions, disomies or associated FISH-detectable centromeric satellite polymorphisms, Kitsberg et al. [4] found that the paternal allele was the early replicating one in all the imprinted genes which they had analyzed. Subsequently, however, Knoll et al. [5] detected genes in the imprinted Prader-Willi region on chromosome 15, which also displayed other patterns. Therefore, it seems necessary to specify the relative timing of maternally and paternally derived alleles for each individual asynchronously replicating gene. Unfortunately, this is so far only feasible with a very restricted number of sequences.
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Masika, Hagit, Marganit Farago, Merav Hecht, Reba Condiotti, Kirill Makedonski, Yosef Buganim, Tal Burstyn-Cohen, Yehudit Bergman, and Howard Cedar. "Programming asynchronous replication in stem cells." Nature Structural & Molecular Biology 24, no. 12 (November 13, 2017): 1132–38. http://dx.doi.org/10.1038/nsmb.3503.

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Frolund, S., and R. Guerraoui. "Implementing E-transactions with asynchronous replication." IEEE Transactions on Parallel and Distributed Systems 12, no. 2 (2001): 133–46. http://dx.doi.org/10.1109/71.910869.

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Tsepenko, V. V., G. F. Mikhailova, T. G. Shkavrova, E. V. Goloub, G. O. Rukhadze, and V. Yu Skoropad. "Asynchronous replication of AURKA and TP53 genes in gastric cancer patients and patients with multiple tumors." Advances in molecular oncology 6, no. 2 (July 27, 2019): 42–47. http://dx.doi.org/10.17650/2313-805x-2019-6-2-42-47.

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Background. The correct genome replication is essential for normal cell division to guarantee that genetic information comes changeless through the next cells generations. DNA replication is a strictly regulated and synchronous process and its disturbances could result to mutations appearances. Aberrant time of DNA replication affects on gene expression causes changes of epigenetic modifications and influences on increasing the structural rearrangements leading to enhanced genome disbalance. Replication time failure as asynchronous replication is common for cancerogeneses. The objective of our study was the assessment of asynchronous replication levels in patients with gastric cancer and patients with multiple tumors.Materials and methods. Fluorescence in situ hybridization (FISH) was used for the asynchronous replication of AURKA and TP53 genes analyses. Interphase FISH on lymphocytes of peripheral blood of 37 healthy donors, 19 patients with non-cancer gastrointestinal pathologies, 68 patients with solitary gastric cancer and 39 patients with multiple tumors having gastric cancer and other second synchronous or metachronous tumor was carried out.Results. Values of lymphocytes with asynchronous replication for AURKA were 19.8 ± 0.5 % for control group, 24.7 ± 0.4 % for non-cancer patients, 32.5 ± 0.5 % for gastric cancer patients, 39.5 ± 0.6 % for patients with multiple tumors and 17.3 ± 0.5, 19.5 ± 0.7, 26.1 ± 0.7 and 32.5 ± 0.6 % for TP53 respectively. Differences between cell populations of examined groups had statistical significance with p <0.01 for both studied gene. Also there was statistical difference between gastric cancer patients having distant metastases and gastric cancer patients without metastases for AURKA (34.4 ± 1.0 % vs. 31.7 ± 0.6 %; p = 0.02).Conclusion. High lymphocytes with asynchronous replication level in oncological patients could serve as potential marker of second tumor or possible metastatic process including the earliest stage of it.
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Guikema, Jeroen E. J., Conny de Boer, Jules Gadiot, Ed Schuuring, and Philip M. Kluin. "Altered Replication Timing of IGH Alleles in Burkitt’s Lymphoma Depends on IGH Breakpoint Position." Blood 104, no. 11 (November 16, 2004): 4276. http://dx.doi.org/10.1182/blood.v104.11.4276.4276.

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Abstract Monoallelic expression of immunoglobulin genes is epigenetically regulated and maintained. Asynchronous replication of the IGH alleles has been implicated in allelic exclusion. Usually, the functional IGH allele replicates early in the S-phase of the cell cycle whereas the non-functional allele replicates late. Previously, the intronic enhancer region (Eμ) and the 3′ Cα enhancer region have been designated as putative replication initiation sites. Activity of these replication origins are likely to be involved in regulation of asynchronous replication. By use of interphase and DNA fiber FISH we have performed a detailed analysis of the configuration of the t(8;14) chromosomal translocation in Burkitt’s lymphoma patients and cell lines and showed that the breakpoints in all studied cases were perfectly reciprocal without loss of IGH genomic material. An important implication is that in patients and cell lines harboring a breakpoint in a downstream switch region (Sγ or Sα) the Eμ and the 3′ Cα enhancer region are physically separated from each other, whereas in patients and cell lines with the IGH breakpoint located in the JH-region both enhancer regions remain on the der(14) chromosome. We therefore studied the IGH replication timing in Burkitt’s lymphoma cell lines harboring different IGH breakpoints by use of BrdU-FISH and interphase FISH on sorted cell cycle fractions. In two cell lines with JH-region breakpoints (Jiyoye and DG-75) the t(8;14) was invariably targeted to the late replicating IGH allele. In contrast, in all three cell lines with switch-region breakpoints (CA-46, Namalwa, BL-65) asynchronous replication of the IGH alleles was lost. As the position of the breakpoint in the MYC locus at 8q24 differed substantially between these cell lines (DG-75 and CA-46: intron 1 of the c-myc gene; Jiyoye, Namalwa, and BL-65: 100 kb to &gt;500 kb centromeric from c-myc) it is unlikely that the position of the 8q24 breakpoint is of crucial influence on IGH replication timing. We speculate that the Eμ and the 3′ Cα enhancer region regulate the IGH replication timing in a cis-acting manner as physical separation of both enhancer regions results in loss of asynchronous replication.
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Dissertations / Theses on the topic "Asynchronous replication"

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Ensminger, Alexander Wilson. "Autosomal random asynchronous replication is analogous to X-chromosome inactivation." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34197.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2006.
Includes bibliographical references.
A number of mammalian genes are expressed from only one of two alleles in either an imprinted or random manner. Those belonging to the random class include X-linked genes subject to X inactivation, as well as a number of autosomal genes, including odorant receptors, immunoglobulins, T-cell receptors, interleukins, natural killer-cell receptors, and pheromone receptors. Random asynchronous replication of DNA in S-phase represents an epigenetic mark that often parallels monoallelic expression. All randomly monoallelically expressed genes discovered to date replicate asynchronously in S-phase, though not all of the genes contained within asynchronous domains are monoallelically expressed. The focus of my work has been on understanding this random choice that cells make between two sequence-identical alleles. Using two-color fluorescent in situ hybridization (FISH) analyses, the random asynchronous replication of a large number of human and mouse genes appears to be coordinated at the level of entire chromosomes. This regulatory scheme is reminiscent of random X-chromosome inactivation, the dosage compensation machinery in mammals. We have shown that autosomal coordination responds to trisomy in a fashion similar to X inactivation, with one copy of the trisomic chromosome marked for early replication and the other two rendered late replicating.
(cont.) These observations raise the intriguing possibility that the mechanistic underpinnings of X inactivation and autosomal coordination may also be similar. Furthermore, the existence of chromosome-wide epigenetic differentiation between autosomes has evolutionary implications concerning the establishment of X inactivation as the approach to mammalian dosage compensation. A crucial event in X inactivation is the random monoallelic expression of a noncoding RNA, Xist from one of the two X chromosomes. Noncoding RNA transcripts are enticing candidates for regulating chromatin structure within the mammalian nucleus. We have initiated a screen for novel nuclear, noncoding RNA transcripts. Using expression array profiling, we have identified several broadly expressed nuclear enriched transcripts. In addition to Xist, this approach identified two noncoding transcripts, NEATI and NEAT2 that are located near one another on human chromosome 1 I and chromosome 19 of mice. Using a variety of techniques, including RNA FISH and RNA-mediated interference, we have explored the potential regulatory functions of these transcripts.
by Alexander Wilson Ensminger.
Ph.D.
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Dobre, Dan. "Time-Efficient Asynchronous Service Replication." Phd thesis, 2010. https://tuprints.ulb.tu-darmstadt.de/2300/1/thesis.pdf.

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Modern critical computer applications often require continuous and correct operation despite the failure of critical system components. In a distributed system, fault-tolerance can be achieved by creating multiple copies of the functionality and placing them at different processes. The core constitutes a distributed protocol run among the processes whose goal is to provide the end user with the illusion of sequentially accessing a single correct copy. Not surprisingly, the efficiency of the distributed protocol used has a severe impact on the application performance. This thesis investigates the cost associated with implementing fundamental abstractions constituting the core of service replication in asynchronous distributed systems, namely (a) consensus and (b) the read/write register. The main question addressed by this thesis is how efficient implementations of these abstractions can be. The focus of the thesis lies on time complexity (or latency) as the main effciency metric, expressed as the number of communication steps carried out by the algorithm before it terminates. Besides latency, important cost factors are the resilience of an algorithm (i.e. the fraction of failures tolerated) and its message complexity (the number of messages exchanged). Consensus is perhaps the most fundamental problem in distributed computing. In the consensus problem, processes propose values and unanimously agree on one of the proposed values. In a purely asynchronous system, in which there is no upper bound on message transmission delays, consensus is impossible if a single process may crash. In practice however, systems are not asynchronous. They are timely in the common case and exhibit asynchronous behavior only occasionally. This observation has led to the concept of unreliable failure detectors to capture the synchrony conditions sufficient to solve consensus. This thesis studies the consensus problem in asynchronous systems in which processes may fail by crashing, enriched with unreliable failure detectors. It determines how quickly consensus can be solved in the common case, characterized by stable executions in which all failures have reliably been detected, settling important questions about consensus time complexity. Besides consensus, the read/write register abstraction is essential to sharing information in distributed systems, also referred to as distributed storage for its importance as a building-block in practical distributed storage and le systems. We study fault-tolerant read/write register implementations in which the data shared by a set of clients is replicated on a set of storage base objects. We consider robust storage implementations characterized by (a) wait-freedom (i.e. the fact the read/write operations invoked by correct clients always return) and (b) strong consistency guarantees despite a threshold of object failures. We allow for the most general type of object failure, Byzantine, without assuming authenticated data to limit the adversary. In this model, we determine the worst-case time complexity of accessing such a robust storage, closing several fundamental complexity gaps.
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Dobre, Dan [Verfasser]. "Time-efficient asynchronous service replication / vorgelegt von Dan Dobre." 2010. http://d-nb.info/100756864X/34.

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Ramasamy, Harigovind Venkatraj. "Parsimonious service replication for tolerating malicious attacks in asynchronous environments /." 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3223699.

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Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3913. Adviser: William H. Sanders. Includes bibliographical references (leaves 189-193) Available on microfilm from Pro Quest Information and Learning.
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Wright, Megan Lynne. "Investigating the evolution of replication timing and monoallelic expression in mammals and birds." Thesis, 2015. http://hdl.handle.net/2440/102613.

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Monoallelic expression and replication timing are closely linked fundamental aspects of genome biology, yet their evolutionary trajectory has not been investigated in much detail. The monoallelic expression status of imprinted genes observed in therian species has previously not been found in the earlier-diverged monotreme mammals, or in birds, when measured using molecular techniques. Furthermore, the observation that eutherian imprinted and X-borne genes asynchronously replicate was traditionally thought to be linked to the dissimilar epigenetic states that existed at each allele controlling monoallelic expression. In this study, we use a combination of cytogenetic and molecular techniques to assess the replication status of sex chromosome genes in the platypus and chicken, as well as the replication status and expression pattern of platypus imprinted orthologs. We find that asynchronous replication does occur at specific sex chromosome loci in platypus and chicken, although in chicken the amount of asynchronous replication changes over development. Furthermore, differential chromatin compaction is observed in platypus sex chromosomes, a characteristic observed in therian X-inactivation, suggesting that both asynchronous replication and chromatin compaction are features characteristic of amniote sex chromosomes. Asynchronous replication and monoallelic expression is observed at platypus imprinted orthologs, indicating that a ‘pre-imprinted’ status is observed at these genes in non-therian amniote species. These results show that monoallelic expression predates imprinting at these loci, suggesting that the partial monoallelic expression observed in monotreme mammals has evolved in therian mammals to become parentally-inherited imprinted expression.
Thesis (Ph.D.) (Research by Publication) -- University of Adelaide, School of Molecular and Biomedical Science, 2015.
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Book chapters on the topic "Asynchronous replication"

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Dong, Huanqing, and Zhanhuai Li. "Optimization of Asynchronous Volume Replication Protocol." In Lecture Notes in Computer Science, 140–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-39425-9_16.

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Carvalho, Nuno, Paolo Romano, and Luís Rodrigues. "Asynchronous Lease-Based Replication of Software Transactional Memory." In Middleware 2010, 376–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16955-7_19.

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Rodrigues, Luís, and Michel Raynal. "Quorum-Based Replication in Asynchronous Crash-Recovery Distributed Systems." In Euro-Par 2000 Parallel Processing, 605–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-44520-x_84.

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Björnerstedt, Anders, Helena Ketoja, Johan Sintorn, and Martin Sköld. "Replication between Geographically Separated Clusters - An Asynchronous Scalable Replication Mechanism for Very High Availability." In Lecture Notes in Computer Science, 102–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/3-540-45432-2_8.

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Ben-Chaim, Yochai, and Avigdor Gal. "Second Order Snapshot-Log Relations: Supporting Multi-directional Database Replication Using Asynchronous Snapshot Replication." In Next Generation Information Technologies and Systems, 221–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11780991_20.

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Federica, Lo Sardo. "Analysis of Single-Locus Replication Timing in Asynchronous Cycling Cells." In Methods in Molecular Biology, 55–65. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6380-5_5.

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Cordero, Marcos Orellana, Gerardo Orellana Cordero, and Esteban Crespo Martinez. "An Open Source Synchronous and Asynchronous Approach for Database Replication." In Advances in Intelligent Systems and Computing, 45–56. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02828-2_4.

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Wang, Yanlong, Zhanhuai Li, Wei Lin, Minglei Hei, and Jianhua Hao. "The Design of Finite State Machine for Asynchronous Replication Protocol." In Advanced Intelligent Computing Theories and Applications. With Aspects of Artificial Intelligence, 1042–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-74205-0_108.

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Park, Taesoon, Ilsoo Byun, and Heon Y. Yeom. "Lazy Agent Replication and Asynchronous Consensus for the Fault-Tolerant Mobile Agent System." In Lecture Notes in Computer Science, 1060–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-24693-0_87.

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Domingues, Helves Humberto, Fabio Kon, and João Eduardo Ferreira. "Asynchronous Replication for Evolutionary Database Development: A Design for the Experimental Assessment of a Novel Approach." In On the Move to Meaningful Internet Systems: OTM 2011, 818–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-25106-1_29.

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Conference papers on the topic "Asynchronous replication"

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Wang, Chao, Zhanhuai Li, and Kun Ren. "ARPRG: An asynchronous replication protocol with RPO guarantee." In 2010 2nd International Conference on Computer Engineering and Technology. IEEE, 2010. http://dx.doi.org/10.1109/iccet.2010.5485935.

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Wang, Yanlong, Zhanhuai Li, and Wei Lin. "RWAR: A Resilient Window-consistent Asynchronous Replication Protocol." In Second International Conference on Availability, Reliability and Security (ARES'07). IEEE, 2007. http://dx.doi.org/10.1109/ares.2007.128.

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Colesa, A., I. Stan, and I. Ignat. "Transparent Fault-Tolerance Based on Asynchronous Virtual Machine Replication." In 12th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing (SYNASC 2010). IEEE, 2010. http://dx.doi.org/10.1109/synasc.2010.58.

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Matsui, Sosuke, Hiroyuki Miyoshi, Hiroshi Araki, Norie Iwasaki, and Thomas W. Bish. "Improving the Performance of Asynchronous Replication with Mixed-Mode Copying." In Middleware '15: 16th International Middleware Conference. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2830894.2830902.

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Averbuch, Amir, Tomer Margalit, Nezer Zaidenberg, and Eviatar Khen. "Low Bitrate Asynchronous Replication of Block Devices and Virtual Machines." In 2011 6th IEEE International Conference on Networking, Architecture, and Storage (NAS). IEEE, 2011. http://dx.doi.org/10.1109/nas.2011.46.

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Yu Tang, Hailong Sun, Xu Wang, Xudong Liu, and Zhenglin Xia. "Achieving convergent causal consistency and high availability with asynchronous replication." In 2016 IEEE/ACM 24th International Symposium on Quality of Service (IWQoS). IEEE, 2016. http://dx.doi.org/10.1109/iwqos.2016.7590407.

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Kostadinov, Bojan, Mile Jovanov, and Emil Stankov. "Cost-effective website failover through a CDN network and asynchronous replication." In IEEE EUROCON 2017 -17th International Conference on Smart Technologies. IEEE, 2017. http://dx.doi.org/10.1109/eurocon.2017.8011095.

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de Macedo, Douglas D. J., Hilton W. G. Perantunes, Luiz F. J. Maia, Eros Comunello, Aldo von Wangenheim, and M. A. R. Dantas. "An interoperability approach based on asynchronous replication among distributed internet databases." In 2008 IEEE Symposium on Computers and Communications (ISCC). IEEE, 2008. http://dx.doi.org/10.1109/iscc.2008.4625712.

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"ASYNCHRONOUS REPLICATION CONFLICT CLASSIFICATION, DETECTION AND RESOLUTION FOR HETEROGENEOUS DATA GRIDS." In 2nd International Conference on Software and Data Technologies. SciTePress - Science and and Technology Publications, 2007. http://dx.doi.org/10.5220/0001344002150219.

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de Macedo, Douglas Dyllon Jeronimo, Hilton Ganzo William Perantunes, Rafael Andrade, Aldo von Wangenheim, and Mario Antonio Ribeiro Dantas. "Asynchronous Data Replication: A National Integration Strategy for Databases on Telemedicine Network." In 21st IEEE International Symposium on Computer-Based Medical Systems (CBMS 2008). IEEE, 2008. http://dx.doi.org/10.1109/cbms.2008.76.

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