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Relevant bibliographies by topics / Asthma in children

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Academic literature on the topic 'Asthma in children'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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Journal articles on the topic "Asthma in children"

1

Daines, Luke, and Ann McMurray. "Asthma in children." InnovAiT: Education and inspiration for general practice 10, no. 1 (November 23, 2016): 5–14. http://dx.doi.org/10.1177/1755738016678013.

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Asthma affects 1 100 000 children in the UK and is thus the most common long-term condition of childhood. The prevalence of childhood asthma symptoms in the UK is among the highest worldwide and this contributes to the estimated £1 billion annual cost of asthma care to the NHS. Children still die from asthma despite advances in its management, and mortality rates have changed very little over the past 20 years. The recent national review of asthma deaths provided a stark reminder of ‘why asthma still kills’ and made key recommendations for children with asthma. However, evidence-based recommendations are still poorly implemented. This article seeks to enthuse the next generation of GPs to prioritise the improvement of asthma care in children.

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Shah, Dr Rameez. "Evaluation of Asthma in Children with Tonsillitis." International Journal of Scientific Research 3, no. 4 (June 1, 2012): 318–21. http://dx.doi.org/10.15373/22778179/apr2014/111.

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Najmitdinovna, Kudratova Gulsara, and Ibragimova Yulduz Botyrovna. "PREVENTION OF BRONCHIAL ASTHMA IN CHILDREN AND TEENAGERS." American Journal Of Biomedical Science & Pharmaceutical Innovation 4, no. 3 (March 1, 2024): 52–55. http://dx.doi.org/10.37547/ajbspi/volume04issue03-07.

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Bronchial asthma is considered a chronic disease and causes many health problems for the population. The disease is based on a genetic predisposition. Children whose parents have allergic diseases (bronchial asthma, allergic rhinitis, atopic dermatitis, eczema, Quincke's edema, etc.) have asthma in the first year of life the tendency to develop the disease is high. (25% if father or mother is sick with allergic diseases, 50% if allergic diseases are observed in both father and mother).

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Rais, Heena, Fehmina Arif, and Sangeeta Santosh. "ASTHMATIC CHILDREN;." Professional Medical Journal 21, no. 04 (December 10, 2018): 739–44. http://dx.doi.org/10.29309/tpmj/2014.21.04.2313.

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Objective: To determine the knowledge and practice of parents of children withAsthma. Introduction: Asthma is a disease characterized by recurrent attacks of breathlessnessand wheezing typically begins in early childhood with an earlier onset in males than females. Lifetime prevalence of asthma is 13.5% and current asthma prevalence of 9.3% among children <18years. According to WHO 15 million disability adjusted life years (DALY) are lost annually due toAsthma. Prevalence of asthma in Pakistani children is 19%. Due to rapid industrialization andurbanization prevalence of Asthma has increased from 9 t0 20% during the last decade. Thisstudy was conducted to assess the extent of knowledge and practice which are associated withthe control of Asthma. Methodology: It was descriptive cross sectional study conducted in ED,Pediatric unit CHK. Sampling was convenience and the study duration six months. One hundredand twenty parents of asthmatic children from 4-13 years of age were selected. Results: Averageage of the children was 7.69±2.58 years (95% CI: 7.23 to 8.16) and average duration of illnesswas 3.08±2.0 years (95% CI: 2.69 to 3.45). Minimum duration was two years and maximum tenyears. One hundred and four mothers (86.7%) and 16 fathers(13.3%) participated in the study.Over all asthma knowledge and practice of parents was adequate in 20(16.7%), inadequate in46(39.3%) and average in 54(45%). Conclusions: Asthma knowledge especially about themanagement is inadequate and practices are also inappropriate in the urban population ofKarachi.

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Pijnenburg, Mariëlle W., Eugenio Baraldi, Paul L. P. Brand, Kai-Håkon Carlsen, Ernst Eber, Thomas Frischer, Gunilla Hedlin, et al. "Monitoring asthma in children." European Respiratory Journal 45, no. 4 (March 5, 2015): 906–25. http://dx.doi.org/10.1183/09031936.00088814.

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The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all components of asthma, such as symptoms, lung function, bronchial hyperresponsiveness and inflammation, may exist in various combinations in different individuals, to date there is limited evidence on how to integrate these for optimal monitoring of children with asthma. The aims of this ERS Task Force were to describe the current practise and give an overview of the best available evidence on how to monitor children with asthma.22 clinical and research experts reviewed the literature. A modified Delphi method and four Task Force meetings were used to reach a consensus.This statement summarises the literature on monitoring children with asthma. Available tools for monitoring children with asthma, such as clinical tools, lung function, bronchial responsiveness and inflammatory markers, are described as are the ways in which they may be used in children with asthma. Management-related issues, comorbidities and environmental factors are summarised.Despite considerable interest in monitoring asthma in children, for many aspects of monitoring asthma in children there is a substantial lack of evidence.

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Khalmatova, Barno T., and Gulnoza A. Toshmatova. "LEUKOTRIENE RECEPTORS STATE IN CHILDREN WITH BRONCHIAL ASTHMA." International Journal of Psychosocial Rehabilitation 24, no. 04 (February 28, 2020): 2099–104. http://dx.doi.org/10.37200/ijpr/v24i4/pr201320.

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Syabbalo, Nightingale. "Biologics in the Treatment of Severe Uncontrolled Asthma in Children." Journal of Thoracic Disease and Cardiothoracic Surgery 2, no. 2 (August 11, 2021): 01–08. http://dx.doi.org/10.31579/2693-2156/024.

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Asthma is the most common chronic disease in children, currently affecting about 7 million children. Severe uncontrolled asthma is rare in children with a prevalence of about 2.1% to 5%, but inflicts a disproportionate health burden. Children with severe asthma have increased risk of life threatening exacerbations, frequent hospitalization, worsening health-related quality of life, and impaired physical activity. Severe asthma in childhood is associated with long-term morbidities, such as bronchiolitis obliterans, impaired airway development, and development of chronic obstructive pulmonary disease in adulthood. Childhood asthma like adult-onset asthma, is classified into four cellular inflammatory phenotypes using induced sputum cytometry. The four phenotypes of asthma include eosinophilic asthma, neutrophilic asthma, paucigranulocytic asthma, and mixed cellularity asthma. The pathophysiological mechanisms of asthma involve airway inflammation and remodeling. Inflammatory mediators such as cytokines, chemokines, adhesion molecules, and growth factors play a key role in orchestration airway remodeling. During airway inflammation, cytokines secreted by type 2 helper (Th2) lymphocytes, such as interleukin-5 (IL-5), IL-4, IL-13, IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) play a key role in the pathogenesis of eosinophilic asthma. Whereas, the Th17 axis cytokines, including IL-17, IL-23, and IL-8 are responsible for the pathophysiology of neutrophilic asthma. The airway structural changes due to airway remodeling lead to thickening of the airway wall, narrowing of the bronchiolar lumen, airway obstruction, and decline in pulmonary function. Most of the children with asthma respond to low and medium inhaled corticosteroids, however a significant proportion still have severe asthma uncontrolled on the standard of care. The most common asthma phenotype in children is eosinophilic asthma, which responds superbly to biologic therapy. Children with severe asthma require add-on targeted interleukin antagonists (ILA), such as mepolizumab (anti-IL-5), benralizumab (anti-IL-5Rα), and dupilumab (anti-4Rα). ILAs have been shown to ameliorate asthma symptoms, reduce moderate and severe exacerbations, and improve pulmonary function. Additionally, ILAs have been demonstrated to improve the health-related quality of life, and have steroid sparing effect.

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Barnes, Greta. "Asthma in children." Nursing Standard 3, no. 29 (April 15, 1989): 20–21. http://dx.doi.org/10.7748/ns.3.29.20.s55.

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Wooler, Edwina. "Asthma in children." Paediatric Nursing 5, no. 6 (July 1993): 22–27. http://dx.doi.org/10.7748/paed.5.6.22.s16.

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Wooler, Edwina. "Asthma in children." Paediatric Nursing 6, no. 10 (December 1994): 29–35. http://dx.doi.org/10.7748/paed.6.10.29.s29.

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Dissertations / Theses on the topic "Asthma in children"

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Russell, Linda Moreno. "The effects of family functioning, child behaviors, and asthma beliefs on asthma management in children and adolescents /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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Kamath, S. V. "Inflammation in paediatric asthma." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269034.

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Mai, Xiao-Mei. "Asthma, bronchial hyperresponsiveness and body weight in children /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med806s.pdf.

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Toop, Leslie John. "Cough sound analysis in children with asthma." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361104.

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Myslytska, H. O., and U. I. Marusyk. "Аtopic reactivity in children with bronchial asthma." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18411.

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Tan, Chee Chun. "Spirometry Use in Children Hospitalized with Asthma." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321888428.

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溫煜讚 and Yuk-tsan Wun. "A study of the peak expiratory flow rates in children in a general practice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981422.

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Hederos, Carl-Axel. "Asthma in young children : epidemiology, burden of asthma and effects of a parental information program /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-251-4/.

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Smith, Nerida Ann. "The effects of intervention on medication compliance and asthma control in children with asthma." Thesis, The University of Sydney, 1987. http://hdl.handle.net/2123/1613.

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Asthma can be a chronic disorder requiring regular medications if the symptoms are persistent. The regimen is often complex, involving a number of drugs and a variety or routes of administration. Although drug therapy may not alter the natural history of asthma it can improve lung function enabling those with asthma to lead as near a normal life as possible. Thus medication compliance is an important factor in the managemnt of asthma. (Note : Special enclosures (Publication reprints) at end of thesis have been removed for digital submission, with permission of author)

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Smith, Nerida Ann. "The effects of intervention on medication compliance and asthma control in children with asthma." University of Sydney, 1987. http://hdl.handle.net/2123/1613.

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Doctor of Philosophy
Asthma can be a chronic disorder requiring regular medications if the symptoms are persistent. The regimen is often complex, involving a number of drugs and a variety or routes of administration. Although drug therapy may not alter the natural history of asthma it can improve lung function enabling those with asthma to lead as near a normal life as possible. Thus medication compliance is an important factor in the managemnt of asthma. (Note : Special enclosures (Publication reprints) at end of thesis have been removed for digital submission, with permission of author)

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Books on the topic "Asthma in children"

1

Campaign, National Asthma. The asthma generation: A National Asthma Campaign report on childhood asthma. London: National Asthma Campaign, 1994.

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Berger, William E. Asthma. New York, NY: Facts On File, 2007.

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Kaplan, D. W. Asthma in children and adolescents. (Switzerland): Karger, 1991.

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United States. Environmental Protection Agency. Child and Aging Health Protection Division. Children's environmental health disparities: Black and African American children and asthma. [Washington, DC]: U. S. Environmental Protection Agency, Child and Aging Health Protection Division, 2008.

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United States. Environmental Protection Agency. Child and Aging Health Protection Division. Children's environmental health disparities: Hispanic and Latino American children and secondhand smoke. [Washington, DC]: U. S. Environmental Protection Agency, Child and Aging Health Protection Division, 2008.

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Bee, Peta. I have asthma. New York: Gareth Stevens Pub., 2011.

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W, Busse W., and Lemanske Robert F, eds. Asthma prevention. Boca Raton, FL: Taylor & Francis, 2005.

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Forno, Erick, and Sejal Saglani, eds. Severe Asthma in Children and Adolescents. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-27431-3.

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9

Hyde, Margaret O. Living with asthma. New York: Walker, 1995.

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1944-, Murphy Shirley, and Kelly H. William, eds. Pediatric asthma. New York: M. Dekker, 1999.

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Book chapters on the topic "Asthma in children"

1

Götz, M., I. Eichler, C. Wojnarowski, and D. Y. Koller. "Allergic asthma in children." In Asthma, 95–103. Vienna: Springer Vienna, 1993. http://dx.doi.org/10.1007/978-3-7091-7537-8_9.

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Kerrebijn, K. F. "Management of Asthmatic Children." In Asthma Treatment, 215–29. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3446-4_20.

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Virant, Frank S., and Gail G. Shapiro. "Treatment of Asthma in Children." In Bronchial Asthma, 273–98. Totowa, NJ: Humana Press, 1994. http://dx.doi.org/10.1007/978-1-4612-0297-4_12.

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Chang, Christopher. "Treatment of Asthma in Children." In Bronchial Asthma, 155–99. Totowa, NJ: Humana Press, 2001. http://dx.doi.org/10.1007/978-1-59259-127-5_7.

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Mattes, Joerg, and Stanley Szefler. "Severe asthma: mechanisms in children." In Severe Asthma, 231–45. Sheffield, United Kingdom: European Respiratory Society, 2019. http://dx.doi.org/10.1183/2312508x.10024318.

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Maxwell, Barbara. "Asthma." In Care Planning in Children and Young People's Nursing, 191–98. West Sussex, UK: John Wiley & Sons, Ltd,., 2013. http://dx.doi.org/10.1002/9781118785324.ch20.

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Teague, W. Gerald, and Graham Roberts. "Clinical phenotypes of severe asthma: children." In Severe Asthma, 64–81. Sheffield, United Kingdom: European Respiratory Society, 2019. http://dx.doi.org/10.1183/2312508x.10023018.

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Martinez-Garri, Marina, and Jonathan M. Gaffin. "Asthma Plus: Comorbidities in Severe Childhood Asthma." In Severe Asthma in Children and Adolescents, 73–93. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27431-3_4.

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Haktanir Abul, Mehtap, Ahmad Salahaddine Naja, Anne Fitzpatrick, Wanda Phipatanakul, and Louise Fleming. "Evaluation and management of severe asthma in children." In Severe Asthma, 246–64. Sheffield, United Kingdom: European Respiratory Society, 2019. http://dx.doi.org/10.1183/2312508x.10024418.

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Evans, David. "Asthma in School Children Reducing the Impact on Education." In Bronchial Asthma, 691–712. Totowa, NJ: Humana Press, 1994. http://dx.doi.org/10.1007/978-1-4612-0297-4_30.

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Conference papers on the topic "Asthma in children"

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Oluwole, Oluwafemi, Donna Rennie, Donna Goodridge, Trent Litzenberger, Luan Chu, Ulfat Khanam, and Josh Lawson. "The course of asthma in preschool children with asthma." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2781.

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Radic, Snezana, Branislava Milenkovic, Biljana Medjo, Olivera Vlahovic, Ana Neskovic, and Milka Micic Stanojevic. "Creating asthma friendly environment for children with asthma in Belgrade." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4501.

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Shah, S., A. M. Fitzpatrick, S. Stephenson, and M. Brown. "Eosinophil Phenotypes in Children with Asthma: Association with Asthma Control." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7187.

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Krasteva, Niya, Boiko Shentov, Stanimira Elkina, and Nikolai Bulgaranov. "Bronchial asthma presentation in obese children." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4505.

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Chaves, Gabriela, Thalita Macêdo, Diana Freitas, Raquel Britto, and Karla Mendonça. "Breathing exercises for children with asthma." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa965.

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Baan, Esmé, Hettie Janssens, Tine Kerckaert, Johan De Jongste, Miriam Sturkenboom, and Katia Verhamme. "Antibiotic use in children with asthma." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa3449.

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Leiria-Pinto, Paula, Pedro Martins, Elena Finelli, Joana Belo, João Marques, Isabel Peralta, Miguel Paiva, Sara Prates, and Nuno Neuparth. "Asthma control in preschool wheezing children." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3361.

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Concepcion, Emily, Katharina D. Graw-Panzer, Alex Sternberg, Madu Rao, and Haesoon Lee. "Exercise Induced Asthma In Obese Children." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1900.

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Cvejoska-Cholakovska, Valentina, Emilija Vlashki, and Vesna Velikj-Stefanovska. "Asthma and atopy in overweight children." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.pa5353.

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Herrera Gana, Ana María, and Gabriel Cavada Chacon. "Asthma hospitalization rates and asthma mortality in Chilean Children: 2008-2014." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa1289.

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Reports on the topic "Asthma in children"

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Rojas Smith, Lucia, Megan L. Clayton, Carol Woodell, and Carol Mansfield. The Role of Patient Navigators in Improving Caregiver Management of Childhood Asthma. RTI Press, April 2017. http://dx.doi.org/10.3768/rtipress.2017.rr.0030.1704.

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Childhood asthma is a significant public health problem in the United States. Barriers to effective asthma management in children include the need for caregivers to identify and manage diverse environmental triggers and promote appropriate use of preventive asthma medications. Although health care providers may introduce asthma treatments and care plans, many providers lack the time and capacity to educate caregivers about asthma in an ongoing, sustained manner. To help address these complexities of asthma care, many providers and caregivers rely on patient navigators (defined as persons who provide patients with a particular set of services and who address barriers to care) (Dohan & Schrag, 2005). Despite growing interest in their value for chronic disease management, researchers and providers know little about how or what benefits patient navigators can provide to caregivers in managing asthma in children. To explore this issue, we conducted a mixed-method evaluation involving focus groups and a survey with caregivers of children with moderate-to-severe asthma who were enrolled in the Merck Childhood Asthma Network Initiative (MCAN). Findings suggest that patient navigators may support children’s asthma management by providing individualized treatment plans and hands-on practice, improving caregivers’ understanding of environmental triggers and their mitigation, and giving clear, accessible instructions for proper medication management. Study results may help to clarify and further develop the role of patient navigators for the effective management of asthma in children.

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BS, Quon, FitzGerald JM, Lemière C, Shahidi N, and Ducharme FM. Increased versus stable doses of inhaled steroids for exacerbations of chronic asthma in adults and children: Protocol. Epistemonikos Interactive Evidence Synthesis, November 2023. http://dx.doi.org/10.30846/ies.b984bf9656.

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Background Written action plans providing guidance in the early treatment of asthma exacerbations have traditionally advocated doubling of inhaled corticosteroids (ICS) as one of the first steps in treatment. Objectives To compare the clinical effectiveness of increasing the dose of ICS versus keeping the usual maintenance dose as part of a patientinitiated action plan at the onset of asthma exacerbations. Search methods We searched the Cochrane Airways Group Specialised Register (last search October 2009) which is derived from searches of CENTRAL, MEDLINE, EMBASE and CINAHL, as well as handsearched respiratory journals and meeting abstracts. Selection criteria Randomised controlled trials (RCTs) that compared the strategy of increasing the daily dose of ICS to continuing the same ICS dose in the home management of asthma exacerbations in children or adults with persistent asthma on daily maintenance ICS. Data collection and analysis Two review authors independently selected trials, assessed quality and extracted data. We contacted authors of RCTs for additional information Main results Five RCTs (four parallel-group and one cross-over) involving a total of 1250 patients (28 children and 1222 adults) with mild to moderate asthma were included. The mean daily baseline ICS dose was 555 mcg (range 200 mcg to 795 mcg) and the mean daily ICS dose achieved following increase was 1520 mcg (range 1000 mcg to 2075 mcg), in CFC beclomethasone dipropionate equivalents. Three parallel-group studies in adults (two doubling and one quadrupling; mean achieved daily dose of 1695 mcg with a range of 1420 to 2075 mcg), involving 1080 patients contributed data to the primary outcome. There was no significant reduction in the need for rescue oral corticosteroids when patients were randomised to the increased ICS compared to stable maintenance dose groups (OR 0.85, 95% CI 0.58 to 1.26). There was no significant difference in the overall risk of non-serious adverse events associated with the increased ICS dose strategy, but the wide confidence interval prevents a firm conclusion. No serious adverse events were reported. Authors’ conclusions There is very little evidence from trials in children. In adults with asthma on daily maintenance ICS, a self-initiated ICS increase to 1000 to 2000 mcg/day at the onset of an exacerbation is not associated with a statistically significant reduction in the risk of exacerbations requiring rescue oral corticosteroids. More research is needed to assess the effectiveness of increased ICS doses at the onset of asthma exacerbations (particularly in children).

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BS, Quon, FitzGerald JM, Lemière C, Shahidi N, and Ducharme FM. Increased versus stable doses of inhaled steroids for exacerbations of chronic asthma in adults and children: Protocol. Epistemonikos Interactive Evidence Synthesis, January 2010. http://dx.doi.org/10.30846/ies.b984bf9656.v1.

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Background Written action plans providing guidance in the early treatment of asthma exacerbations have traditionally advocated doubling of inhaled corticosteroids (ICS) as one of the first steps in treatment. Objectives To compare the clinical effectiveness of increasing the dose of ICS versus keeping the usual maintenance dose as part of a patientinitiated action plan at the onset of asthma exacerbations. Search methods We searched the Cochrane Airways Group Specialised Register (last search October 2009) which is derived from searches of CENTRAL, MEDLINE, EMBASE and CINAHL, as well as handsearched respiratory journals and meeting abstracts. Selection criteria Randomised controlled trials (RCTs) that compared the strategy of increasing the daily dose of ICS to continuing the same ICS dose in the home management of asthma exacerbations in children or adults with persistent asthma on daily maintenance ICS. Data collection and analysis Two review authors independently selected trials, assessed quality and extracted data. We contacted authors of RCTs for additional information Main results Five RCTs (four parallel-group and one cross-over) involving a total of 1250 patients (28 children and 1222 adults) with mild to moderate asthma were included. The mean daily baseline ICS dose was 555 mcg (range 200 mcg to 795 mcg) and the mean daily ICS dose achieved following increase was 1520 mcg (range 1000 mcg to 2075 mcg), in CFC beclomethasone dipropionate equivalents. Three parallel-group studies in adults (two doubling and one quadrupling; mean achieved daily dose of 1695 mcg with a range of 1420 to 2075 mcg), involving 1080 patients contributed data to the primary outcome. There was no significant reduction in the need for rescue oral corticosteroids when patients were randomised to the increased ICS compared to stable maintenance dose groups (OR 0.85, 95% CI 0.58 to 1.26). There was no significant difference in the overall risk of non-serious adverse events associated with the increased ICS dose strategy, but the wide confidence interval prevents a firm conclusion. No serious adverse events were reported. Authors’ conclusions There is very little evidence from trials in children. In adults with asthma on daily maintenance ICS, a self-initiated ICS increase to 1000 to 2000 mcg/day at the onset of an exacerbation is not associated with a statistically significant reduction in the risk of exacerbations requiring rescue oral corticosteroids. More research is needed to assess the effectiveness of increased ICS doses at the onset of asthma exacerbations (particularly in children).

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BS, Quon, FitzGerald JM, Lemière C, Shahidi N, and Ducharme FM. Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children: Baseline review. Epistemonikos Interactive Evidence Synthesis, January 2010. http://dx.doi.org/10.30846/ies.b984bf9639.v1.

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Background Written action plans providing guidance in the early treatment of asthma exacerbations have traditionally advocated doubling of inhaled corticosteroids (ICS) as one of the first steps in treatment. Objectives To compare the clinical effectiveness of increasing the dose of ICS versus keeping the usual maintenance dose as part of a patientinitiated action plan at the onset of asthma exacerbations. Search methods We searched the Cochrane Airways Group Specialised Register (last search October 2009) which is derived from searches of CENTRAL, MEDLINE, EMBASE and CINAHL, as well as handsearched respiratory journals and meeting abstracts. Selection criteria Randomised controlled trials (RCTs) that compared the strategy of increasing the daily dose of ICS to continuing the same ICS dose in the home management of asthma exacerbations in children or adults with persistent asthma on daily maintenance ICS. Data collection and analysis Two review authors independently selected trials, assessed quality and extracted data. We contacted authors of RCTs for additional information Main results Five RCTs (four parallel-group and one cross-over) involving a total of 1250 patients (28 children and 1222 adults) with mild to moderate asthma were included. The mean daily baseline ICS dose was 555 mcg (range 200 mcg to 795 mcg) and the mean daily ICS dose achieved following increase was 1520 mcg (range 1000 mcg to 2075 mcg), in CFC beclomethasone dipropionate equivalents. Three parallel-group studies in adults (two doubling and one quadrupling; mean achieved daily dose of 1695 mcg with a range of 1420 to 2075 mcg), involving 1080 patients contributed data to the primary outcome. There was no significant reduction in the need for rescue oral corticosteroids when patients were randomised to the increased ICS compared to stable maintenance dose groups (OR 0.85, 95% CI 0.58 to 1.26). There was no significant difference in the overall risk of non-serious adverse events associated with the increased ICS dose strategy, but the wide confidence interval prevents a firm conclusion. No serious adverse events were reported. Authors’ conclusions There is very little evidence from trials in children. In adults with asthma on daily maintenance ICS, a self-initiated ICS increase to 1000 to 2000 mcg/day at the onset of an exacerbation is not associated with a statistically significant reduction in the risk of exacerbations requiring rescue oral corticosteroids. More research is needed to assess the effectiveness of increased ICS doses at the onset of asthma exacerbations (particularly in children).

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Sumino, Kaharu, Leonard Bacharier, Juanita Taylor, Kelley Chadwick-Mansker, Vanessa Curtis, Alison Nash, Shawni Jackson-Triggs, et al. Comparing Two Ways to Manage Asthma in African American Children—The ASIST Study. Patient-Centered Outcomes Research Institute® (PCORI), August 2020. http://dx.doi.org/10.25302/07.2020.as.130705588.

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MacDonald-Wilson, Kim, Gregory McHugo, Kelly Williams, Chaeryon Kang, Patricia Deegan, William Torrey, Nancy Parrotta, et al. Comparing Two Ways to Manage Asthma in African American Children—The ASIST Study. Patient-Centered Outcomes Research Institute® (PCORI), August 2020. http://dx.doi.org/10.25302/07.2020.cdr.130602474.

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Wysocki, Tim, Mauri Carakushansky, Daniel Doyle, Mark Kummer, Judith Ross, Grafton Reeves, Neil Izenberg, et al. Comparing Two Ways to Manage Asthma in African American Children—The ASIST Study. Patient-Centered Outcomes Research Institute® (PCORI), August 2020. http://dx.doi.org/10.25302/02.2020.cer.805.

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Sun, Bo, Xushu Cui, and Bing Wei. Obesity and lung function in children with asthma–a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2023. http://dx.doi.org/10.37766/inplasy2023.10.0079.

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B, Quon, FitzGerald JM, Ducharme FM, Lasserson TJ, and Lemière C. Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children. Epistemonikos Interactive Evidence Synthesis, January 2009. http://dx.doi.org/10.30846/ies.b984bf9699.p1.

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Abstract This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review will be to compare the safety and efficacy of increasing the dose of ICS as part of a supervised patient self‐management action plan to continuing the usual maintenance dose of ICS at the onset of exacerbations in children and adults with asthma.

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B, Quon, FitzGerald JM, Ducharme FM, Lasserson TJ, and Lemière C. Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children: Protocol. Epistemonikos Interactive Evidence Synthesis, January 2009. http://dx.doi.org/10.30846/ies.b984bf9639.p1.

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Abstract This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review will be to compare the safety and efficacy of increasing the dose of ICS as part of a supervised patient self‐management action plan to continuing the usual maintenance dose of ICS at the onset of exacerbations in children and adults with asthma.

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