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Academic literature on the topic 'Astaxanthin'

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Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "Astaxanthin"

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Nishida, Yasuhiro, Allah Nawaz, Karen Hecht, and Kazuyuki Tobe. "Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants." Nutrients 14, no. 1 (December 27, 2021): 107. http://dx.doi.org/10.3390/nu14010107.

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Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms, and has been gaining attention in recent years due to its varied biological/physiological activities. It has been reported that astaxanthin functions both as a pigment, and as an antioxidant with superior free radical quenching capacity. We recently reported that astaxanthin modulated mitochondrial functions by a novel mechanism independent of its antioxidant function. In this paper, we review astaxanthin’s well-known antioxidant activity, and expand on astaxanthin’s lesser-known molecular targets, and its role in mitochondrial energy metabolism.
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Mularczyk, Malwina, Nabila Bourebaba, Krzysztof Marycz, and Lynda Bourebaba. "Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis." Biomolecules 12, no. 8 (July 27, 2022): 1039. http://dx.doi.org/10.3390/biom12081039.

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Astaxanthin is gaining recognition as a natural bioactive component. This study aimed to test whether astaxanthin could protect adipose-derived stromal stem cells (ASCs) from apoptosis, mitochondrial dysfunction and oxidative stress. Phaffia rhodozyma was used to extract astaxanthin, whose biocompatibility was tested after 24, 48 and 72 h of incubation with the cells; no harmful impact was found. ASCs were treated with optimal concentrations of astaxanthin. Several parameters were examined: cell viability, apoptosis, reactive oxygen levels, mitochondrial dynamics and metabolism, superoxide dismutase activity, and astaxanthin’s antioxidant capacity. A RT PCR analysis was performed after each test. The astaxanthin treatment significantly reduced apoptosis by modifying the normalized caspase activity of pro-apoptotic pathways (p21, p53, and Bax). Furthermore, by regulating the expression of related master factors SOD1, SOD2, PARKIN, PINK 1, and MFN 1, astaxanthin alleviated the oxidative stress and mitochondrial dynamics failure caused by EMS. Astaxanthin restored mitochondrial oxidative phosphorylation by stimulating markers associated with the OXPHOS machinery: COX4I1, COX4I2, UQCRC2, NDUFA9, and TFAM. Our results suggest that astaxanthin has the potential to open new possibilities for potential bio-drugs to control and suppress oxidative stress, thereby improving the overall metabolic status of equine ASCs suffering from metabolic syndrome.
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Turujman, Saleh A., Wayne G. Wamer, Rong Rong Wei, and Richard H. Albert. "Rapid Liquid Chromatographic Method to Distinguish Wild Salmon from Aquacultured Salmon Fed Synthetic Astaxanthin." Journal of AOAC INTERNATIONAL 80, no. 3 (May 1, 1997): 622–32. http://dx.doi.org/10.1093/jaoac/80.3.622.

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Abstract Analytical methods are needed to determine the presence of color additives in fish. We report a liquid chromatographic (LC) method developed to identify the synthetic form of the color additive astaxanthin in salmon, based on differences in the relative ratios of the configurational isomers of astaxanthin. The distributions of configurational isomers of astaxanthin in the flesh of wild Atlantic and wild Pacific salmon are similar, but significantly different from that in aquacultured salmon. Astaxanthin is extracted from the flesh of salmon, passed through a silica gel Sep-Pak cartridge, and analyzed directly by LC on a Pirkle covalent L-leucine column. No derivatization of the astaxanthin is required—an important advantage of our approach, which is a modification of our previously described method. This method can be used to distinguish between aquacultured and wild salmon. The method has general applicability and can also be used to identify astaxanthins derived from other sources such as Phaffia yeast and Haematococcus pluvialis algae.
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Rodriguez-Ruiz, Violeta, José Salatti-Dorado, Abolfazl Barzegari, Alba Nicolas-Boluda, Amel Houaoui, Carmen Caballo, Noelia Caballero-Casero, et al. "Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity." Molecules 23, no. 10 (October 11, 2018): 2601. http://dx.doi.org/10.3390/molecules23102601.

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Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin’s antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented. Their antioxidant activity was measured by α-Tocopherol Equivalent Antioxidant Capacity assay and was compared to those of both natural astaxanthin and α-tocopherol. Characterizations by dynamic light scattering, atomic force microscopy, and scattering electron microscopy techniques were carried out and showed spherical and surface negative charged particles with z-average and polydispersity values of ~60 nm and ~0.3, respectively. Astaxanthin loading was also investigated showing an astaxanthin recovery of more than 90% after synthesis of nanostructured lipid carriers. These results demonstrate the capability of the formulation to stabilize astaxanthin molecule and preserve and enhance the antioxidant activity.
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Šimat, Vida, Nikheel Bhojraj Rathod, Martina Čagalj, Imen Hamed, and Ivana Generalić Mekinić. "Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application." Marine Drugs 20, no. 3 (March 12, 2022): 206. http://dx.doi.org/10.3390/md20030206.

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In recent years, the food, pharma, and cosmetic industries have shown considerable interest in bioactive molecules of marine origin that show high potential for application as nutraceuticals and therapeutic agents. Astaxanthin, a lipid-soluble and orange-reddish-colored carotenoid pigment, is one of the most investigated pigments. Natural astaxanthin is mainly produced from microalgae, and it shows much stronger antioxidant properties than its synthetic counterpart. This paper aims to summarize and discuss the important aspects and recent findings associated with the possible use of crustacean byproducts as a source of astaxanthin. In the last five years of research on the crustaceans and their byproducts as a source of natural astaxanthin, there are many new findings regarding the astaxanthin content in different species and new green extraction protocols for its extraction. However, there is a lack of information on the amounts of astaxanthin currently obtained from the byproducts as well as on the cost-effectiveness of the astaxanthin production from the byproducts. Improvement in these areas would most certainly contribute to the reduction of waste and reuse in the crustacean processing industry. Successful exploitation of byproducts for recovery of this valuable compound would have both environmental and social benefits. Finally, astaxanthin’s strong biological activity and prominent health benefits have been discussed in the paper.
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Laja, Rana Salsabila Putri. "Astaxanthin untuk Kesehatan Kardiovaskular." Jurnal Penelitian Perawat Profesional 3, no. 2 (April 13, 2021): 243–52. http://dx.doi.org/10.37287/jppp.v3i2.259.

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Penyakit kardiovaskular adalah penyebab utama kematian di seluruh dunia. Adanya dislipidemia, gangguan toleransi glukosa, dan hipertensi dengan akumulasi lemak visceral yang disebut sindrom metabolik, meningkatkan risiko penyakit kardiovaskular. Sindrom metabolik sering ditandai dengan stres oksidatif, gangguan keseimbangan antara produksi reactive oxygen species dan pertahanan antioksidan. Sementara itu, astaxanthine diketahui memiliki karakteristik antioksidan yang kuat, yang telah dilaporkan melampaui karakteristik β-karoten atau bahkan α-tokoferol. Penelitian ini merupakan literature review yang melibatkan sebanyak 20 sumber pustaka dengan kata kunci yang digunakan antara lain ‘astaxanthin, cardiovascular disease dan xanthophyll carotenoid’ dengan tahun terbit antara 2006-2020. Abstrak dan full text jurnal dibaca dan dicermati, kemudian dilakukan analisis terhadap isi yang terdapat dalam tujuan penelitian dan hasil/temuan penelitian. Beberapa penelitian menunjukkan adanya beberapa manfaat yang dapat secara langsung atau tidak langsung dari astaxanthin berkaitan dengan potensi antioksidannya, termasuk kemampuannya untuk mengurangi atau menetralkan produksi ROS, sehingga meningkatkan aktivitas enzim pembersih radikal. Astaxanthin juga berperan sebagai anti inflamasi dan berperan dalam metabolisme lipid melalui efek hipokolesterolemik serta melindungi dari iskemia reperfusi. Astaxanthin di ketahui dapat memberikan manfaat bagi kesehatan kardiovaskular melalui berbagai mekanisme seperti peran antioksidan yang lebih baik, anti inflamasi, efek hipokolesterolemik dalam metabolisme lipid dan melindungi dari iskemia reperfusi.
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Aribisala, Jamiu Olaseni, Sonto Nkosi, Kehinde Idowu, Ismaila Olanrewaju Nurain, Gaositwe Melvin Makolomakwa, Francis O. Shode, and Saheed Sabiu. "Astaxanthin-Mediated Bacterial Lethality: Evidence from Oxidative Stress Contribution and Molecular Dynamics Simulation." Oxidative Medicine and Cellular Longevity 2021 (December 9, 2021): 1–24. http://dx.doi.org/10.1155/2021/7159652.

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The involvement of cellular oxidative stress in antibacterial therapy has remained a topical issue over the years. In this study, the contribution of oxidative stress to astaxanthin-mediated bacterial lethality was evaluated in silico and in vitro. For the in vitro analysis, the minimum inhibitory concentration (MIC) of astaxanthin was lower than that of novobiocin against Staphylococcus aureus but generally higher than those of the reference antibiotics against other test organisms. The level of superoxide anion of the tested organisms increased significantly following treatment with astaxanthin when compared with DMSO-treated cells. This increase compared favorably with those observed with the reference antibiotics and was consistent with a decrease in the concentration of glutathione (GSH) and corresponding significant increase in ADP/ATP ratio. These observations are suggestive of probable involvement of oxidative stress in antibacterial capability of astaxanthin and in agreement with the results of the in silico evaluations, where the free energy scores of astaxanthins’ complexes with topoisomerase IV ParC and ParE were higher than those of the reference antibiotics. These observations were consistent with the structural stability and compactness of the complexes as astaxanthin was observed to be more stable against topoisomerase IV ParC and ParE than DNA Gyrase A and B. Put together, findings from this study underscored the nature and mechanism of antibacterial action of astaxanthin that could suggest practical approaches in enhancing our current knowledge of antibacterial arsenal and aid in the novel development of alternative natural topo2A inhibitor.
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Toyoshima, Hiroki, Ami Miyata, Risako Yoshida, Taichiro Ishige, Shinichi Takaichi, and Shinji Kawasaki. "Distribution of the Water-Soluble Astaxanthin Binding Carotenoprotein (AstaP) in Scenedesmaceae." Marine Drugs 19, no. 6 (June 20, 2021): 349. http://dx.doi.org/10.3390/md19060349.

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Photooxidative stress-inducible water-soluble astaxanthin-binding proteins, designated as AstaP, were identified in two Scenedesmaceae strains, Coelastrella astaxanthina Ki-4 and Scenedesmus obtusus Oki-4N; both strains were isolated under high light conditions. These AstaPs are classified as a novel family of carotenoprotein and are useful for providing valuable astaxanthin in water-soluble form; however, the distribution of AstaP orthologs in other microalgae remains unknown. Here, we examined the distribution of AstaP orthologs in the family Scenedesmaceae with two model microalgae, Chlamydomonas reinhardtii and Chlorella variabilis. The expression of AstaP orthologs under photooxidative stress conditions was detected in cell extracts of Scenedesmaceae strains, but not in model algal strains. Aqueous orange proteins produced by Scenedesmaceae strains were shown to bind astaxanthin. The protein from Scenedesmus costatus SAG 46.88 was purified. It was named ScosAstaP and found to bind astaxanthin. The deduced amino acid sequence from a gene encoding ScosAstaP showed 62% identity to Ki-4 AstaP. The expression of the genes encoding AstaP orthologs was shown to be inducible under photooxidative stress conditions; however, the production amounts of AstaP orthologs were estimated to be approximately 5 to 10 times lower than that of Ki-4 and Oki-4N.
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BAUMANN, LESLIE S. "Astaxanthin." Skin & Allergy News 43, no. 3 (March 2012): 23. http://dx.doi.org/10.1016/s0037-6337(12)70100-6.

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Kindlund, Petra J. "Astaxanthin." Nutrafoods 10, no. 1 (January 2011): 27–31. http://dx.doi.org/10.1007/bf03223352.

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Dissertations / Theses on the topic "Astaxanthin"

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Silva, Danielle Alves da. "Maximização da produção de astaxantina por Phaffia rhodozyma (Xanthophyllomyces dendrohous) utilizando água de parboilização do arroz." reponame:Repositório Institucional da FURG, 2009. http://repositorio.furg.br/handle/1/2575.

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Dissertação(mestrado) - Universidade Federal do Rio Grande, Programa de Pós-Graduação em Engenharia e Ciência de Alimentos, Escola de Química e Alimentos, 2009.
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O interesse na produção de astaxantina por fontes naturais vem aumentando significativamente nos últimos anos, devido a possibilidade de atuar como corante e sua capacidade antioxidante biológica potente. É o carotenóide principal encontrado na levedura Phaffia rhodozyma, sendo esse microrganismo adequado para o uso como fonte do pigmento industrial em razão de seu metabolismo heterotrófico, padrão de crescimento relativamente rápido, qualidade nutricional e seguro como aditivo alimentar. A presente dissertação teve como objetivo principal realizar cultivos utilizando a levedura Phaffia rhodozyma, estudando diferentes meios de cultura, empregando a água de parboilização do arroz como substrato. Inicialmente selecionou-se dentre 3 cepas de P. rhodozyma: NRRL Y-17268, NRRL Y-10921 e NRRL Y-10922, a mais promissora quanto a produção de astaxantina, utilizando glicose e sacarose como fonte de carbono. Os cultivos foram realizados em frascos agitados a 25ºC, 150rpm, por um período de 168h. Através do acompanhamento da bioprodução de astaxantina, a levedura P. rhodozyma NRRL Y-17268 foi selecionada, pois se destacou como boa produtora do carotenóide, alcançando 7,0g.L-1 de biomassa, 350,2μg.g-1 de produção de astaxantina específica e 2,4μg.mL-1 de astaxantina volumétrica, utilizando sacarose. Utilizou-se a metodologia de planejamento experimenta e análise de superfície de resposta para verificar os efeitos das variáveis em estudo e as condições que levaram a melhor bioprodução da astaxantina. Um planejamento experimental fracionário 2IV 6-2 foi realizado para determinar as variáveis que mais influenciavam na produção da astaxantina. As variáveis independentes estudadas foram concentrações de extrato de levedura (1 a 10g.L-1), extrato de malte (1 a 10g.L-1), peptona (1 a 10g.L-1), sacarose (5 a 20g.L-1), efluente da parboilização do arroz (0 a 180g.L-1) e o pH inicial do meio (4 a 6), tendo como resposta a produção de biomassa, produção de astaxantina específica e produção de astaxantina volumétrica. Os valores máximos obtidos foram 8,9g.L-1 de biomassa, 538,4μg.g-1 de astaxantina específica e 3,1μg.mL-1 de astaxantina volumétrica, em diferentes condições de composição de meio de cultivo. O extrato de levedura não apresentou efeito significativo em nenhuma das respostas avaliadas, sendo realizado um teste de Tukey na faixa de 0 a 1g.L-1. A concentração de extrato de levedura não apresentou diferença significativa, sendo retirado do meio de cultivo. No segundo planejamento foram ampliadas as faixas de estudo das variáveis selecionadas: concentrações de extrato de malte (8,75 a 16,25g.L-1), sacarose (15 a 35g.L-1), peptona (8,75 a 16,25g.L-1) e o pH mantido no ponto central 5,0. A partir dos resultados, verificou-se um incremento na concentração máxima de biomassa obtida, alcançando 10,9g.L-1 e na produção de astaxantina específica para 628,8μg.g-1. As melhores condições encontradas através das superfícies de resposta para maximização da produção de astaxantina volumétrica foram: 16,25g.L-1 de extrato de malte, 8,75g.L-1 de peptona, 15g.L-1 de sacarose e 87,5g.L-1 de água de parboilização do arroz, alcançando em torno de 5,4μg.mL-1.
The interest in astaxanthin production by natural sources has increased significantly in the last few years, because of its possibility of acting as corants and its powerfull biological antioxidant capacity. It’s the most important carotenoid found in the yeast Phaffia rhodozyma and this microorganism is appropriate to use in the source of industrial pigment due to its heterotrophic metabolism, relatively rapid growth, nutritional quality and safe as a food additive. The present dissertation had as main objective, through fermentation, using the yeast Phaffia rhodozyma studying different culture medium and the rice parboilization wastewater as a substrate. Firstly, the greatest astaxanthin producer, using glucose and sucrose as carbon source was selected amongst three strains of Phaffia rhodozyma: NRRL Y-17268, NRRL Y-10921 and NRRL Y-10922. The cultivation condition was realized in a rotatory flasks, at 25ºC, 150rpm, for 168h. Through the accompaniment of the bioproduction of astaxanthin, the yeast P. rhodozyma NRRL Y-17268 was selected, because it stood out as a good producer of the carotenoid, 7.0g.L-1 of biomass, 350.2μg.g-1 of specific production of astaxanthin and 2.4μg.mL-1 of volumetric production of astaxanthin, using sucrose. The techniques of experimental design and analysis of response surfaces were used to verify the effects of the studied variables and the condictions wich led to the best production of astaxanthin. A fractional experimental design 2IV 6-2 was used to determine the independents variables that most influenced in the production of astaxanhin. The studied independents variables were yeast extract concentration (1 to 10g.L-1), malt extract (1 to 10g.L-1), peptone (1 to 10g.L-1), sucrose (5 to 20g.L-1), rice parboilization wastewater (0 to 180g.L-1) and the initial pH (4 to 6), having as answer the biomass production, specific production of astaxanthin and volumetric production of astaxanthin. The highest values obtained were 8.9g.L-1 of biomass, 538.4μg.g-1 of specific astaxanthin and 3.1μg.mL-1 of volumetric astaxanthin, in differents conditions of composition of cultivation medium. The yeast extract didn’t show significant effect in any answer, being made a Tukey test in the range of 0 to 1g.L-1. In this test the yeast extract concentration didn’t show significant difference, then it was removed from the cultivation medium. In a second design the range were amplied: malt extract concentration (8.75 to 16.25g.L-1), sucrose (15 to 35g.L-1), peptone (8.75 to 16.25g.L-1) and the pH was maintained in the central point (5.0). From the results, verify an increased in the maximum biomass concentration obtained, reaching 10.9g.L-1 and in a specific production of astaxanthin to 628.8μg.g-1. The better conditions found through of response surface to the maximization of volumetric production of astaxanthin was: 16.25g.L-1 of malt extract, 8.75g.L-1 of peptone, 15g.L-1 of sucrose and 87.5g.L-1 of rice parboilization waste water, reaching around 5.4μg.mL-1.
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Zuluaga, tamayo Marisol. "Systèmes hydrophiles antioxydants pour applications cardiovasculaires : synthèse, caractérisation, études in vitro et in vivo." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCD041/document.

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Une présence en excès d'espèces réactives oxygénées induit un déséquilibre redox cellulaire pouvant conduire à des pathologies liées au stress oxydatif, notamment les pathologies cardiovasculaires. Connue et étudiée pour ses propriétés antioxydantes, l’astaxanthine, molécule de la famille des caroténoïdes, présente un intérêt thérapeutique potentiel. Cependant, sa structure chimique lui confère un caractère hydrophobe ainsi qu’une sensibilité à l’air, à la lumière et à la chaleur. Dans cette thèse, tout d’abord, un système de complexation de l’astaxanthine avec l’hydroxypropyl-b-cyclodextrine a été élaboré (CD-A). Nous démontrons que cette complexation améliore la stabilité de l’astaxanthine en solution aqueuse tout en préservant ses activités antioxydantes, mesurées par des méthodes chimiques et biologiques. L’action du CD-A semble être médiée par les voies de signalisation PTEN/AKT, Nrf2/OH1/NQO1 dans des cellules endothéliales soumises au stress oxydatif. Puis, afin de libérer l’astaxanthine in situ sur le site du stress, nous avons élaboré deux systèmes de type matriciel en PVA/dextrane ou en pullulane/dextrane chargés en CD-A. Nous avons évalué, comme preuve de concept, la faisabilité de ces dispositifs pour le traitement local de la pathologie d’ischémie/reperfusion. Les patchs de PVA/dextrane/CD-A ont montré une bonne compatibilité in vitro, ainsi qu’une grande stabilité et tenue mécanique sans modification des propriétés antioxydantes. Leur biocompatibilité in vivo et suturabilité au muscle cardiaque ont aussi été étudiées. Le deuxième système à base de pullulane/dextrane/CD-A a été évalué in vitro et in vivo dans un modèle d’ischémie/reperfusion du membre inférieur à différentes périodes d'implantation. Les résultats ont montré l’activation d’un mécanisme de défense normal lié à la présence d’un matériel étranger et une diminution de la translocation du Nrf2 pouvant indiquer un effet protecteur dans les tissus traités par le CD-A. Ce manuscrit présente des arguments en faveur du potentiel thérapeutique de systèmes de libération d’astaxanthine agissant au niveau du stress oxydatif lié aux pathologies cardiovasculaires
An over concentration of reactive oxygen species induces a redox imbalance within the cell inducing oxidative tissue damage and leading to oxidative stress related diseases, particularly cardiovascular pathologies. Astaxanthin, a well-known and studied antioxidant molecule, member of the xanthophyll carotenoid family, presents an important therapeutic potential. However, the chemical structure confers to astaxanthin a hydrophobic character and renders it susceptible to air, light and temperate degradation. During this thesis, a carrier system based on astaxanthin inclusion within hydroxypropyl-β-cyclodextrin(CD-A) was developed. We demonstrate that after astaxanthin inclusion, not only its stability was enhanced by also the antioxidant scavenging capabilities were preserved, confirmed by chemical and biological tests. The action of CD-A seems to be mediated by PTEN/AKT, Nrf2/OH1/NQO1 signaling pathways of endothelial cells submitted to oxidative stress. Then, two systems based on PVA/dextran and Pullulan/Dextran loaded within CD-A were evaluated for astaxanthin in situ delivery in the stressed environment. The feasibility of using these systems in the local treatment of ischemia/reperfusion injury was evaluated as a proof of concept. PVA/Dextran patches showed good in vitro compatibility, high mechanical and stability properties, while preserving CD-A antioxidant capabilities, also the path suturability to the cardiac muscle and the in vivo biocompatibility were studied. The second system based on pullulan/dextran scaffolds were evaluated in vitro and in vivo in an ischemic/reperfusion model at different implantation periods. Results showed an inner body defense mechanism to foreign materials. Additionally, the Nrf2 translocation could indicate a protective effect of CD-A in treated tissues. This manuscript provides a support evidence of the therapeutic potential of CD astaxanthin delivery system, to act against oxidative stress linked to cardiovascular conditions
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Xu, Simin, and 徐思敏. "Characterization of astaxanthin accumulation in green algae." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278553.

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Xu, Simin. "Characterization of astaxanthin accumulation in green algae." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278553.

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Bertolo, Adilson Luís. "Avaliação de um processo de extração e recuperação dos carotenóides presentes no resíduo da industrialização do camarão-rosa (Farfantepenaeus paulensis)." reponame:Repositório Institucional da FURG, 2007. http://repositorio.furg.br/handle/1/3515.

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Dissertação(mestrado) - Universidade Federal do Rio Grande, Programa de Pós-Graduação em Engenharia e Ciência de Alimentos, Escola de Química e Alimentos, 2007.
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A astaxantina é um carotenóide da classe das xantofilas, amplamente distribuída em animais marinhos e aquáticos, sendo muito utilizada em formulações para aqüicultura e por suas propriedades antioxidantes, podendo também ser utilizada como corante alimentício por sua coloração avermelhada. Este carotenóide pode ser extraído de algas, bactérias e também de crustáceos como o camarão-rosa. Este crustáceo é amplamente capturado na região sul do Rio Grande do Sul, sendo que seu processamento gera mais de 60% de resíduos. O aproveitamento destes resíduos surge como uma alternativa a problemas de impacto ambiental, oriundos do seu despejo na lagoa dos Patos, bem como uma fonte alternativa de recursos para as indústrias e pescadores locais. Neste contexto, o objetivo deste trabalho foi a obtenção de carotenoproteína, utilizando resíduos provenientes da industrialização do camarãorosa(Farfantepenaeus paulensis) por meio de hidrólise enzimática com adição da enzima proteolítica Flavourzyme, e a partir dela, a purificação química da astaxantina, visando avaliar quais variáveis do processo possuíam efeito significativo, e depois de obtido o extrato, foi estudada sua estabilidade frente à luz e temperatura, utilizando astaxantina dissolvida em óleo de soja, como oleoresina. Para analisar quais as variáveis que realmente influenciam no processo de obtenção da carotenoproteína, optou-se pela utilização do planejamento experimental saturado 23 com três pontos centrais, onde se têm três variáveis independentes em dois níveis: tempo (2 e 3 h), temperatura (40 e 50ºC) e concentração de enzima/substrato (0,1 e 0,3%); e como variáveis dependentes: rendimento, porcentagem de proteína e de lipídios. As condições ótimas para o processamento foram: tempo de hidrolise de 2 horas, temperatura de hidrólise de 50°C e concentração de Enzima/Substrato de 0,3%, obtendo um rendimento do processo 9,4% , um teor de proteínas de 70,9% e teor de lipídios de 1,6%. Já para o processo de purificação química da carotenoproteína também foi utilizado um planejamento experimental quadrático completo do tipo 23, com três variáveis independentes em dois níveis, sendo elas: tempo de extração (80 e 280 min), temperatura de extração (26,6 e 43,4°C) e proporção de hexano/ acetona (8 e 92%) e como variáveis dependentes a concentração de astaxantina com três pontos centrais e dois axiais, sendo que com um tempo de extração química de 120 mim, temperatura de extração de 30 °C e com uma proporção de Hexano e Acetona de 25% foi obtida a maior concentração de astaxantina que foi de 197,41 ppm.15. Finalmente foi estudada a estabilidade da oleoresina frente ao calor, apresentando-se estável durante as 8 primeiras horas de exposição à temperatura de 105°C. Já na estabilidade frente à luz, a oleoresina mostrou-se estável por um período de 7 dias.
The Astaxanthin is a carotenoide of the xanthophylls class, widely distributed in marine and aquatic animals, and is often used in formulations for aquaculture and for their antioxidant properties and may also be used as food coloring on its reddish color. Astaxanthin can be extracted of seaweed, bacteria and also of crustaceans as the pink-shrimp. The pink-shrimp is amply captured in the southern region of Rio Grande do Sul, where their processing generates more than 60% of waste. The use of such waste emerges as an alternative to problems of the environmental impact of their eviction from the Pato´s lagoon, as well as an alternative source of resources for industries and local fishermen. In this context, the aim of this study is the obtainment of carotenoprotein using wastes from pink-shrimp processing (Farfantepenaeus Paulensis) through the proteolitic enzyme Flavourzyme, and its chemical purification, aiming to evaluate which of the process variables have significant effects. Once obtained the extract, its stability was studied faced to light and temperature, using astaxanthin dissolved in soy resin oil. To analyze the variables that really influenced the process of carotenoprotein obtainment, it was used an experimental design saturated 23, with three independent variables in two levels: time (2 and 3h), temperature (40 and 50°C) and concentration enzyme/substrate (0.1 and 0.3%) and as dependent variables the yield, lipids and proteins percentage, with three central points. The best conditions for processing were hidrolysys time of 2 hours and 50ºC of temperature, concentration enzyme/substrate of 0.3%, and the yield obtained on the process was 9.4%, protein level of 70,9% and lipids of 1.6%. To the process of chemical purification of the carotenoprotein it was also used an experimental design saturated 23, with three independent variables in two levels: time of extraction (80 and 280 minutes), temperature of chemical extraction (26,6 and 43,4°C) and hexane and acetone proportion (8 and 92%) and as dependent variable the astaxanthin concentration, with three central points and two axial points considering 16 an chemical extraction time of 120 minutes, extraction temperature of 30ºC and hexane and acetone in a 25% proportion the highest astaxanthin concentration gained was 197,41 ppm. Finally the stability of the resin oil faced to heat was studied, presenting stable during the 8 early hours of exposure to temperature of 105ºC. Faced to light, the oil resin became stable during 7 days.
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Dermiki, Maria. "Recovery of astaxanthin using colloidal gas aphrons (CGA)." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500537.

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劉愛霞 and Oi-ha Lau. "The growth and astaxanthin formation of haematococcus lacustris." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31215488.

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Grant, Stephanie Mary. "Production of astaxanthin by the yeast Phaffia rhodozyma." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324833.

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Lau, Oi-ha. "The growth and astaxanthin formation of haematococcus lacustris." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19738195.

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Obalil, Jiří. "Miniaturizované techniky pro analýzu průmyslových kvasinek." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216334.

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Carotenoids are natural pigments that have antioxidation and antimutagenic abilities. They are produced with the help of new technological methods. For example, carotenoid yeast Rhodotorula glutinis produces -carotene with the yield of up to 6 – 10 mg/g of the dry substance. The method of the mass spectrometry with the nanoelectrospray in the positive mode was optimized for the determination of -carotene, lycopene and astaxanthin in this project. Ionizing voltage of 4 kV and the sample flow rate of 15 – 80 nl/min through the spray silica fused capillary with the internal diameter of 25 µm were found to be the optimum parameters of the analysis. A mixture of chloroform with the addition of ammonia was used as a spray solvent for both standard and cellular samples. During the process of ionization by nanoelectrospray, -carotene and lycopene form cation radical [M] • + with the molecular mass to charge ratio (m/z) of 536, while asthaxanthin forms the protonated molecule [M + H]+ with the m/z of 597. The partial lysis of individual Rhodotorula glutinis cells was demonstrated under microscope in the organic solvents tetrahydrofuran and dimethylsulfoxide. Chloroform, acetone, acetonitrille, methanol and isopropanol did not affect the cells after a 15 min treatment.
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Books on the topic "Astaxanthin"

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Global Perspectives on Astaxanthin. Elsevier, 2021. http://dx.doi.org/10.1016/c2019-0-01800-6.

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Natural Astaxanthin Hawaii's Supernutrient. William Sears MD, 2015.

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Hosokawa, Masashi, and Hayato Maeda, eds. Fucoxanthin and Astaxanthin—Production, Biofunction, and Application. MDPI, 2023. http://dx.doi.org/10.3390/books978-3-0365-6325-1.

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Melborne, Paul A. Essential Guide to Astaxanthin: Dietary Sources, Properties and Health Benefits. Nova Science Publishers, Incorporated, 2019.

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Nagaraj, Subramani, and Ramasamy Rengasamy. Antioxidant and Anticancer Potential of Haematococcus Pluvialis Flotow: Astaxanthin against Hepatocarcinogenesis. LAP Lambert Academic Publishing, 2012.

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Perfect Lifestyle Perfect Lifestyle Masterminds. Astaxanthin: Die Wahrheit über das Stärkste Natürliche Antioxidans - Wirkung, Einnahme, Dosierung. Independently Published, 2019.

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Ravishankar, G. A., and Rangarao Ambati. Global Perspectives on Astaxanthin: From Industrial Production to Food, Health, and Pharmaceutical Applications. Elsevier Science & Technology Books, 2021.

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Global Perspectives on Astaxanthin: From Industrial Production to Food, Health, and Pharmaceutical Applications. Elsevier Science & Technology, 2021.

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Minatelli, John A. Composition and Method to Alleviate Joint Pain Using Phospholipids and Astaxanthin: United States Patent 9974756. Independently Published, 2020.

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Lilienthal, Tristan. Die 20 Besten Nahrungsergänzungsmittel: Ein Gesundes, Vitales und Langes Leben Mit 5 HTP, Astaxanthin, Alpha Liponsäure, B12, Basenpulver, Kurkuma, Calcium, Chrom, Chlorella, Coenzym Q10, D3. Independently Published, 2017.

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Book chapters on the topic "Astaxanthin"

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Asker, Dalal, Tarek S. Awad, Teruhiko Beppu, and Kenji Ueda. "A Novel Radio-Tolerant Astaxanthin-Producing Bacterium Reveals a New Astaxanthin Derivative: Astaxanthin Dirhamnoside." In Microbial Carotenoids from Bacteria and Microalgae, 61–97. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-879-5_4.

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Butler, Thomas, and Yonatan Golan. "Astaxanthin Production from Microalgae." In Microalgae Biotechnology for Food, Health and High Value Products, 175–242. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-0169-2_6.

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Alcaino, Jennifer, Marcelo Baeza, and Victor Cifuentes. "Astaxanthin and Related Xanthophylls." In Fungal Biology, 187–208. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1191-2_9.

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Johnson, Eric A., and William A. Schroeder. "Biotechnology of Astaxanthin Production inPhaffia rhodozyma." In ACS Symposium Series, 39–50. Washington, DC: American Chemical Society, 1996. http://dx.doi.org/10.1021/bk-1996-0637.ch004.

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Hayashi, Masahiro, Takashi Ishibashi, Daichi Kuwahara, and Kazuaki Hirasawa. "Commercial Production of Astaxanthin with Paracoccus carotinifaciens." In Advances in Experimental Medicine and Biology, 11–20. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-7360-6_2.

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Cheng, Qiong, and Luan Tao. "Engineering Escherichia coli for Canthaxanthin and Astaxanthin Biosynthesis." In Microbial Carotenoids from Bacteria and Microalgae, 143–58. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-879-5_7.

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Naito, Yuji, Kazuhiko Uchiyama, Osamu Handa, and Wataru Aoi. "Therapeutic Potential of Astaxanthin in Diabetic Kidney Disease." In Advances in Experimental Medicine and Biology, 239–48. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-7360-6_22.

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Fayaazuddin, Thajuddin, Palanivel Prakash, Thajuddin Shakena Fathima, and Dharumadurai Dhanasekaran. "Commercial Astaxanthin Production from Green Alga Haematococcus pluvialis." In Food Microbiology Based Entrepreneurship, 279–304. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-5041-4_15.

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Del Río, Esperanza, F. Gabriel Acién, and Miguel G. Guerrero. "Photoautotrophic Production of Astaxanthin by the Microalga Haematococcus pluvialis." In Sustainable Biotechnology, 247–58. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3295-9_13.

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Ahuja, Manmeet, Jayesh Varavadekar, Mansi Vora, Piyush Sethia, Harikrishna Reddy, and Vidhya Rangaswamy. "Astaxanthin: Current Advances in Metabolic Engineering of the Carotenoid." In High Value Fermentation Products, 381–99. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2019. http://dx.doi.org/10.1002/9781119460053.ch17.

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Conference papers on the topic "Astaxanthin"

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Krestinin, Roman, Yulia Baburina, Irina Odinokova, Linda Sotnikova, and Olga Krestinina. "ASTAXANTHIN REDUCES ISOPROTERINOL-INDUCED MITOCHONDRIAL DYSFUNCTION." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2183.sudak.ns2021-17/212-213.

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WANG, Jun, and Yan ZHAO. "Astaxanthin in Disease Prevention and Treatment." In 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/bbe-17.2017.67.

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Esser, A., Herbert Fisch, Karl-Heinz Haas, E. Haedicke, J. Paust, Wolfgang Schrof, and Anton Ticktin. "Nonlinear optics of astaxanthin thin films." In San Diego '92, edited by David J. Williams. SPIE, 1993. http://dx.doi.org/10.1117/12.139213.

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Kaczor, Agnieszka, Malgorzata Baranska, P. M. Champion, and L. D. Ziegler. "In Situ Measurement of Astaxanthin In Biological Material." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482545.

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Kumar, Ajitesh, S. K. Karthick Kumar, Aditya Gupta, and Debabrata Goswami. "Spectrally resolved femtosecond photon echo spectroscopy of astaxanthin." In International Conference on Fiber Optics and Photonics, edited by Sunil K. Khijwania, Banshi D. Gupta, Bishnu P. Pal, and Anurag Sharma. SPIE, 2010. http://dx.doi.org/10.1117/12.899781.

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Metheny-Barlow, Linda J., Christine N. McMahan, Kristin M. Stadelman, Anne M. Sanders, and Keith D. Barlow. "Abstract 3728: Astaxanthin as an adjunct therapy for breast cancer." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3728.

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Zhu, Chuanhe, Wei Han, Zhao Chen, and Ziqiang Han. "Statistical optimization of microwave-assisted astaxanthin extraction from Phaffia rhodozym." In 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2010. http://dx.doi.org/10.1109/bmei.2010.5639994.

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Samara, C., G. Papanagiotou, M. Moustaka-Gouni, and C. Chatzidoukas. "A new promising astaxanthin producer: a Greek Haematococcus pluvialis isolate." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759014.

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Guo, Xuewu, Xianyu Li, and Dongguang Xiao. "Optimization of Culture Conditions for Production of Astaxanthin by Phaffia rhodozyma." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516101.

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Kubo, H., K. Asai, K. Iwasaki, T. Kawai, M. Nishimura, N. Maruyama, H. Kadotani, et al. "Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema Through Nrf2 Activation in Mice." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4066.

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Reports on the topic "Astaxanthin"

1

Gantt, Elisabeth, Avigad Vonshak, Sammy Boussiba, Zvi Cohen, and Amos Richmond. Carotenoid-Rich Algal Biomass for Aquaculture: Astaxanthin Production by Haematococcus Pluvialis. United States Department of Agriculture, August 1996. http://dx.doi.org/10.32747/1996.7613036.bard.

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The synthesis of carotenoids has been studied toward enhancing the production of ketocarotenoids, since fish and crustaceans raised by aquaculture require astaxanthin and other ketocaroteinoids in their feed for desirable pigmentation. Notable progress has been made in attaining the goals of determining improved conditions for ketocarotenoid production in Haematococcus pluvialis and in elucidating the carotenoid biosynthetic pathway. For production of astaxanthin a number of strains of the green alga Haematococcus were evaluated, a strain CCAG was found to be optimal for photoautotrophic growth. Of four mutants, selected for enhanced carotenoid production, two hold considerable promise because caroteinoid accumulation occurs without encystment. The biosynthetic pathway of carotenoids was elucidated in photosynthetic organisms by characterizing novel genes encoding carotenoid enzymes and by examining the function of these enzymes in a bacterial complementation system. Two cyclases (b- and e-) were cloned that are at a critical branch point in the pathway. One branch leads to the formation of b-carotene and zeaxanthin and astaxanthin, and the other to the production of a-carotene and lutein. Cyclization of both endgroups of lycopene to yield b-carotene was shown to be catalyzed by a single gene product, b-lycopene cyclase in cyanobacteria and plants. The formation of a-carotene was found to require the e-cyclase gene product in addition to the b-cyclase. By cloning a b-hydroxylase gene we showed that a single gene product forms zeaxanthin by hydroxylatin of both b-carotene rings. It is expected that a second hydroxylase is required in the synthesis of astaxanthin, since canthaxanthin rather than zeaxanthin is the precursor. Evidence, from inhibitor studies, suggests that astaxanthin is formed from canthaxanthin and that b-carotene is a major precursor. Feasibility studies with the photobioreactors have shown that a two-stage system is the most practical, where Haematococcus cultures are first grown to high cell density and are then switched to high light for maximal astaxanthin production. The basic knowledge and molecular tools generated from this study will significantly enhance Haematococcus as a viable model for enhanced astaxanthin production.
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de Boer, Lex, Jelle van den Bos, Wim Graman, Sander Hazewinkel, Silke Hemming, Gerwien Kerkhof, Cees van der Lans, et al. Astaxanthine 2.0 : hoogwaardige inhoudsstoffen uit algen in kassen. Bleiswijk: Wageningen Plant Research, Business unit Glastuinbouw, 2018. http://dx.doi.org/10.18174/455264.

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