Relevant bibliographies by topics / Astature

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  2. Dissertations / Theses
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Academic literature on the topic 'Astature'

Author: Grafiati
Published: 25 May 2024

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Journal articles on the topic "Astature"

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Li, Yawen, Ming-Kuan Chyan, Donald K. Hamlin, Holly Nguyen, Eva Corey, and D. Scott Wilbur. "Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo." International Journal of Molecular Sciences 23, no. 18 (September 13, 2022): 10655. http://dx.doi.org/10.3390/ijms231810655.

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The alpha particle-emitting radionuclide astatine-211 (211At) is of interest for targeted radiotherapy; however, low in vivo stability of many 211At-labeled cancer-targeting molecules has limited its potential. As an alternative labeling method, we evaluated whether a specific type of astatinated aryl compound that has the At atom in a higher oxidation state might be stable to in vivo deastatination. In the research effort, para-iodobenzoic acid methyl ester and dPEG4-amino acid methyl ester derivatives were prepared as HPLC standards. The corresponding para-stannylbenzoic acid derivatives were also prepared and labeled with 125I and 211At. Oxidization of the [125I]iodo- and [211At]astato-benzamidyl-dPEG4-acid methyl ester derivatives provided materials for in vivo evaluation. A biodistribution was conducted in mice with coinjected oxidized 125I- and 211At-labeled compounds. The oxidized radioiodinated derivative was stable to in vivo deiodination, but unfortunately the oxidized [211At]astatinated benzamide derivative was found to be unstable under the conditions of isolation by radio-HPLC (post animal injection). Another biodistribution study in mice evaluated the tissue concentrations of coinjected [211At]NaAtO3 and [125I]NaIO3. Comparison of the tissue concentrations of the isolated material from the oxidized [211At]benzamide derivative with those of [211At]astatate indicated the species obtained after isolation was likely [211At]astatate.
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Nagao, Y., M. Yamaguchi, S. Watanabe, N. S. Ishioka, N. Kawachi, and H. Watabe. "Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows." Journal of Instrumentation 16, no. 12 (December 1, 2021): C12031. http://dx.doi.org/10.1088/1748-0221/16/12/c12031.

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Abstract Astatine-211 is one of the promising radioisotopes for targeted alpha therapy. Optimising treatment strategies as well as determining the suitability of a given agent for a particular patient requires to image the time-dependent distribution of the targeted radiotherapeutic agent both in tumours and in normal tissues. Since the biodistribution of astatine is different from that of iodine, imaging astatine-211 directly is essential. In the previous study of astatine-211 Compton imaging, random coincidence events due to polonium K-shell X-rays were dominant and seemed to cause saturation of counts. Thus optimisation of the coincidence time windows is important to reduce random coincidence events. In this study, we have optimised the coincidence time windows of a Compton camera and improved the sensitivity, noise and spatial resolution of astatine-211 imaging.
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Wilbur, D. "[211At]Astatine-Labeled Compound Stability: Issues with Released [211At]Astatide and Development of Labeling Reagents to Increase Stability." Current Radiopharmaceuticalse 1, no. 3 (September 1, 2008): 144–76. http://dx.doi.org/10.2174/1874471010801030144.

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CORSON, DALE R. "ASTATINE." Chemical & Engineering News 81, no. 36 (September 8, 2003): 158. http://dx.doi.org/10.1021/cen-v081n036.p158.

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Meyer, Geerd-J. "Astatine." Journal of Labelled Compounds and Radiopharmaceuticals 61, no. 3 (February 22, 2018): 154–64. http://dx.doi.org/10.1002/jlcr.3573.

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Wilbur, D. Scott. "Enigmatic astatine." Nature Chemistry 5, no. 3 (February 20, 2013): 246. http://dx.doi.org/10.1038/nchem.1580.

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Sarr, Serigne, Julien Pilmé, Gilles Montavon, Jean-Yves Le Questel, and Nicolas Galland. "Astatine Facing Janus: Halogen Bonding vs. Charge-Shift Bonding." Molecules 26, no. 15 (July 28, 2021): 4568. http://dx.doi.org/10.3390/molecules26154568.

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The nature of halogen-bond interactions was scrutinized from the perspective of astatine, potentially the strongest halogen-bond donor atom. In addition to its remarkable electronic properties (e.g., its higher aromaticity compared to benzene), C6At6 can be involved as a halogen-bond donor and acceptor. Two-component relativistic calculations and quantum chemical topology analyses were performed on C6At6 and its complexes as well as on their iodinated analogues for comparative purposes. The relativistic spin–orbit interaction was used as a tool to disclose the bonding patterns and the mechanisms that contribute to halogen-bond interactions. Despite the stronger polarizability of astatine, halogen bonds formed by C6At6 can be comparable or weaker than those of C6I6. This unexpected finding comes from the charge-shift bonding character of the C–At bonds. Because charge-shift bonding is connected to the Pauli repulsion between the bonding σ electrons and the σ lone-pair of astatine, it weakens the astatine electrophilicity at its σ-hole (reducing the charge transfer contribution to halogen bonding). These two antinomic characters, charge-shift bonding and halogen bonding, can result in weaker At-mediated interactions than their iodinated counterparts.
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Yagishita, Atsushi, Miho Katsuragawa, Shin’ichiro Takeda, Yoshifumi Shirakami, Kazuhiro Ooe, Atsushi Toyoshima, Tadayuki Takahashi, and Tadashi Watabe. "Development and Utility of an Imaging System for Internal Dosimetry of Astatine-211 in Mice." Bioengineering 11, no. 1 (December 26, 2023): 25. http://dx.doi.org/10.3390/bioengineering11010025.

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In targeted radionuclide therapy, determining the absorbed dose of the ligand distributed to the whole body is vital due to its direct influence on therapeutic and adverse effects. However, many targeted alpha therapy drugs present challenges for in vivo quantitative imaging. To address this issue, we developed a planar imaging system equipped with a cadmium telluride semiconductor detector that offers high energy resolution. This system also comprised a 3D-printed tungsten collimator optimized for high sensitivity to astatine-211, an alpha-emitting radionuclide, and adequate spatial resolution for mouse imaging. The imager revealed a spectrum with a distinct peak for X-rays from astatine-211 owing to the high energy resolution, clearly distinguishing these X-rays from the fluorescent X-rays of tungsten. High collimator efficiency (4.5 × 10−4) was achieved, with the maintenance of the spatial resolution required for discerning mouse tissues. Using this system, the activity of astatine-211 in thyroid cancer tumors with and without the expression of the sodium iodide symporter (K1-NIS/K1, respectively) was evaluated through in vivo imaging. The K1-NIS tumors had significantly higher astatine-211 activity (sign test, p = 0.031, n = 6) and significantly decreased post-treatment tumor volume (Student’s t-test, p = 0.005, n = 6). The concurrent examination of intratumor drug distribution and treatment outcome could be performed with the same mice.
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Dzhuzha, D., and S. Myasoyedov. "Radionuclide therapy with alpha-emitters." Radiation Diagnostics, Radiation Therapy, no. 4 (2019): 37–47. http://dx.doi.org/10.37336/2707-0700-2019-4-4.

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In this review the main streams of using alpha-emitters radium-223, actinium-225, bismuth-213, astatine-211 in complex treatment of malignant tumors are reviewed. The features of radiobiological actions of alpha-emission make its more effective in hundred times than beta-emission. The efficacy of this kind of radionuclide therapy does not dependent from chemoresistance and radioresistance to beta-emitters. The results of experimental and initial clinical investigation, which indicate on promising further investigations in this direction, were revealed. Key words: radionuclide therapy of malignant tumors, alpha-emitters, radium-223, actinium-225, bismuth-213, astatine-211.
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Nemec, S. "Glomus intraradix effects on citrus rootstock seedling growth in various potting media." Journal of Agricultural Science 118, no. 3 (June 1992): 315–23. http://dx.doi.org/10.1017/s0021859600070684.

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SUMMARYFive potting media components mixed in various combinations and in various percentages of one with another (0, 14·3, 29, 42, 57, 71 and 100% by volume of the second component with the first) were inoculated with Glomus intraradix in six experiments. Seedlings of citrus rootstocks were grown from seed in these mixes. Sour orange in inoculated peat plus vermiculite, Astatula fine sand plus vermiculite, and peat plus Perlite® in all percentage combinations grew c. two- to threefold taller than noninoculated control plants. Up to twofold growth increases of sour orange occurred in vermiculite amended with wood shavings. The best evidence for fungus-mediated plant growth occurred in Astatula fine sand amended with 29–71% Perlite, and the roots in that combination had the highest percentage of infection. In another experiment in which Astatula fine sand was amended with up to 16% of an acid peat, ratios of inoculated rough lemon plant growth to controls decreased as the peat content in the medium increased. Top and root weight ratios of inoculated:control seedlings in the six experiments did not fit four simple linear models.
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Dissertations / Theses on the topic "Astature"

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Desiree, Patrick R. "Synthèse et développement de macrocycles pour la capture d'anions d'intérêt thérapeutique." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0152.

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La chimie supramoléculaire consiste en l’assemblage par des interactions non-covalentes d’architectures moléculaires plus ou moins complexes. A l’état naturel, ces édifices remplissent de nombreuses fonctions telle que le support génétique par la molécule d’ADN. Les anions peuvent aussi être impliqués au niveau radiothérapeutique par le biais de l’iodure. Par opposition, ce même élément peut être associé à certaines catastrophes environnementales (explosion de Fukishima, 2011) voire à certaines pathologies (thyroïdopathie). Face aux problématiques citées, il est donc primordial de développer des outils permettant de lutter face à ces évènements désastreux. Les travaux présentés ici consistent en l’élaboration de macrocycles de type boronium pouvant piéger de manière efficace l’iodure, anion modèle pour l’étude de la capture de l’astature et encore peu connu, en raison de son faible temps de demi-vie. Cette coordination s’effectue par une collaboration de liaisons hydrogène et d’interactions ioniques. Sur la base des travaux antérieurs réalisés au laboratoire, il a été question d’étudier de manière approfondie les propriétés de complexation des cages synthétisées, les Calix-carBIB. Dans un deuxième temps, de nouveaux groupements fonctionnels ont été utilisés afin d’étudier leur potentiel pour différentes applications, notamment pour la purification de l’astature ou encore la vectorisation. Enfin, une nouvelle génération de récepteurs a été étudiée, présentant en théorie une affinité plus importante pour l’astature
Supramolecular chemistry consists of molecular architecture complex organized thanks to a combination of non-covalent interactions. At the natural state, these structures have numerous functions such as cell energy production thanks to the ATP synthase or the genetic support thanks to a polyanion, the DNA molecule. Anions can be involved in radiotherapy through iodide. By opposition, it can also be associated with environmental disasters (Fukushima explosion in 2011) or some diseases (thyroid disease). In front of these troubles, it is a priority to fight against theses disastrous events. This PhD work has focused on the construction of boronium type macrocycle able to strongly trap iodide which is an anion model to study astatide trapping. This coordination is done thanks to hydrogen bonding and ionic interactions collaboration. Based on previous works realized in our laboratory in 2010, complexation properties of Calix-carBIB were studied. In a second time, new functionalized groups were used to study their potential for different applications such as astatide purification, water solubility and vectorization. Finally, a new receptor generation was studied, showing a better affinity for astatide
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Liu, Lu. "Exploration de la chimie de l'astate en solution : focalisation sur le diagramme de Pourbaix en milieu non complexant et caractérisation de liaisons halogènes induites par l'astate." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2020. http://www.theses.fr/2020IMTA0205.

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L'astate (At, Z = 85) est un élément halogène rare, tous ses isotopes étant radioactifs. En raison des quantités disponibles limitées, aucun outil spectroscopique n'est applicable pour identifier la nature moléculaire des espèces d'At. En conséquence, la chimie de l'At reste méconnue. L'un de ses isotopes, ²¹¹At, est un candidat potentiel pour le traitement de cancers par thérapie alpha ciblée. Cependant, la connaissance limitée de ses propriétés chimiques a entravé les tentatives de marquage de ²¹¹At avec des molécules porteuses ciblant la maladie. Cela a conduit au développement d’un programme de recherches sur la chimie de base de At. Cette thèse s’intéresse plus particulièrement au diagramme de Pourbaix de l’astate et à la caractérisation de liaisons halogènes avec l’espèce AtI, au moyen de divers outils expérimentaux (chromatographie ionique, méthode de compétition et électromobilité). Dans une première partie, des études de spéciation de At en milieu alcalin confirment la présence de l'espèce At⁻ en conditions réductrices. Lorsque le potentiel augmente, l’espèce AtO(OH)₂⁻ se forme. Le changement de spéciation entre ces deux espèces est décrit pour la première fois. Dans une deuxième partie, la formation de liaisons halogènes entre l'espèce AtI et divers composés organiques a été étudiée. La réactivité se résume par une échelle de basicité nouvellement établie dont la force entre le donneur (AtI) et l’atome accepteur varie suivant l’ordre C ≤ O ≤ S (≈ Se)
Astatine (At, Z = 85) is a scarce halogen element, all of its isotopes being radioactive. Due to the limited available quantities, no spectroscopic tool is applicable to identify the molecular nature of At species. Consequently, the chemistry of At remains poorly known. One of its isotopes, ²¹¹At, is a potential candidate for the treatment of cancers by targeted alpha therapy. However, the limited knowledge of its chemical properties has hindered attempts to label ²¹¹At with disease targeting carrier molecules. This led to the development of a research program on the basic chemistry of At. This thesis focuses more particularly on the Pourbaix diagram of astatine and the characterization of halogen bonds with the AtI species, by means of various experimental tools (ion chromatography, competition method and electromobility). In the first part, speciation studies of At in alkaline medium confirm the presence of the At⁻ species under reducing conditions. As the potential increases, the AtO(OH)₂⁻ species is formed. The speciation change between these two species is described for the first time. In a second part, the formation of halogen bonds between the AtI species and various organic compounds was studied. The reactivity is summarized by a newly established basicity scale, with the strength between the donor (AtI) and the acceptor atom following the order of C≤ O ≤ S (≈ Se)
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Da, Silva I., T. Sauvage, P. Rifard, F. Durand, J. P. Trasbot, and N. Michel. "Evolution of production of Astatine-211 in Orléans Cyclotron." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166243.

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Introduction Since 2005, we produce, at academic scale in Orleans, 211At for needs of chemistry and physicians teams of Nantes in research project of alpha immunotherapy. Between 2005 and 2014, several modifications were been made on preparation of target, targetry and radiation to protect personnel. Material and Methods The first target was a molten Bi metal onto a Cu support pre-treated with acid attack. The wished thickness (up to 100 µm) was obtained by mechanical treatment of target. The target is irradiated at 32MeV alpha particle beam for around 2 hours and then delivered by road transport to users. Only a measure of radiation dose was made to evaluate target activity. The second target we have used since 2010 is a electrodeposition of Bi (thickness of around 30 µm) onto AlN backing. We used a beam of 30.5 MeV for reaction 207Bi(α,n)211At (2 h with a current intensity of 2µA). Activity has measured with a detector Ge at 687 keV (γ-branching fraction = 0.26 %) before to be delivered. For all targets, beam energy on target was around 28.7 Mev in order not to produce too much 210At. Results and Conclusion 138 productions with the first target were delivered with an estimated activity of less than 100 MBq. Difficulties with wet extraction1, low yield of radiolabelling (metallic impurities and activation of copper resulting in 66Ga and 67Ga) made necessary to change process of extraction. With support of AlN, dry extraction was used with good yield (75–80 %) and without activation of support. Until today, 46 batchs were delivered with activity of 44 ± 12 MBq/µAh. Yield activity of 211At has been almost doubled compared to first target (25MBq/µAh). The dose burden to personnel was decreased with modification of targetry (outside of blockhouse of cyclotron, in a specific line beam to radionuclide production, cf. FIG. 1). In the case of 211At production, energy of reaction is of major impact. With our versatile accelerator (range of energy in alpha between 10 and 50 MeV) and a low thickness of metal, it’s easy to reach the right energy. This radionuclide production will be continued until ARRONAX, Nantes cyclotron, could take over from us for bigger activity of 211At.
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Champion, Julie. "Exploration du caractère métallique de l'astate en solution aqueuse." Nantes, 2009. http://www.theses.fr/2009NANT2086.

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L'alpha-radiothérapie est une technique particulièrement innovante de thérapie des cancers, tout en étant complémentaire des thérapies déjà existantes. Elle repose sur l'utilisation d'un vecteur spécifique (anticorps ou peptide) de la cellule cible à détruire,radiomarqué » par un élément radioactif émetteur alpha. L'astate 211 est un candidat particulièrement intéressant compte tenu de l'énergie des particules  qu'il émet et de sa période physique (7,2 h). L'une des voies de marquage envisagée est l'utilisation de l'astate à un degré d'oxydation supérieur à zéro en tant que cation. En effet, l'astate est supposé présenter un caractère plus métallique que les autres halogènes du fait de son positionnement dans le tableau périodique. Cette voie de marquage a été peu abordée dans la littérature en raison du manque de données sur la chimie de l'astate aux degrés d'oxydation supérieurs à zéro. Le but de ce travail était donc d'explorer cette propriété de l'astate via la construction du diagramme Eh, pH (ou diagramme de Pourbaix) en milieu aqueux non complexant. Pour ce faire, ce travail s'est appuyé sur une double approche expériementale/théorique. L'approche expérimentale utilise des méthodes dites de compétition pour identifier les espèces formées et les constantes thermodynamiques des équilibres étudiés. L'approche théorique utilise des méthodes de chimie computationnelle et fournie des informations à l'échelle moléculaire sur les systèmes étudiés afin de prédire les données thermodynamiques qui servent de support et complément à l'approche expérimentale. Un résultat important de ce travail montre la présence de deux espèces cationiques stables de l'astate en solution aqueuse, At+ et AtO+
Alpha-radiotherapy is an innovative technique for the treatment of cancers complementary to current approaches. The principle is to use tumor-specific vectors labeled with alpha-radioisotopes. Astatine 211 is a very promising candidate if one considers the energy of the  particles emitted as well as its physical half-life (7. 2 h). One of the ways of labeling is to use astatine at a higher oxidation state as a « metal cation ». Indeed, considering its location in the periodic table, astatine is supposed to present a more metallic character than the other halogens. This way of labeling has however never been explored. This can be explained by the fact that the astatine chemistry is nearly unknown. The purpose of this work was therefore to explore this property of astatine and to define its Eh, pH diagram (or Pourbaix diagram) in non complexing aqueous solution. To this end, both experimental and theoretical approaches were used. The experimental approach uses competition methods to identify the formed species and the thermodynamics constants of studied equilibria. The theoretical approach uses methods of computational chemistry and provides information at the molecular scale on the studied systems in order to predict thermodynamic data which are used as support and complement to the experimental approach. The important result of this work shows the presence of two stable cationic forms of astatine in aqueous solution, i. E;, At+ and AtO+
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Guo, Ning. "Investigation of the chemical properties of astatine at +I and –I oxydation states in aqueous solution." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT4038/document.

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La thérapie alpha ciblée est une technique prometteuse pour le traitement de cancers. L’astate-211, de temps de demi-vie de 7,21 h, est considéré comme un candidat prometteur pour cette application. Une condition pré-requise est de fixer de manière stable l’isotope radioactif sur le vecteur qui va servir à reconnaitre les cellules malades. Ceci demande une connaissance approfondie des propriétés chimiques de l’astate. Compte tenu de sa position dans le tableau périodique des éléments, l’astate peut exister sous la forme At− en cohérence avec les propriétés chimiques des autres halogènes, et possède aussi un caractère plus métallique qui explique l’existence d’espèces cationiques stables. L’objectif de cette thèse est d’identifier et d’étudier les propriétés des différentes espèces de l’astate en solution aqueuse. La prédominance de l’espèce At− en milieu acide réducteur a été confirmée au moyen d’une technique d’électromobilité. Une première valeur de mobilité absolue est ainsi proposée. En milieu plus oxydant, l’espèce At+ domine. La réactivité de cette espèce avec les ions de la série des halogènes a été étudiée/quantifiée. Une espèce exotique IAtBr− a notamment été mise en évidence grâce à l’aide d’outils de modélisation moléculaire. La particularité du compound AtI à former des liaisons de type halogène a été montrée pour la première fois
Targeted alpha therapy is an appealing method for the treatment of cancer as a complement to the current approaches. Astatine-211, with a half-life of 7.21 h, is considered as an exciting prospective candidate for this application. A pre-required condition is to fix in a stable way the radioactive isotope to the vector that is going to serve to recognize cells. This asks for a thorough knowledge of the chemical properties of astatine. Considering its position in the periodic table, it can exist under the form At− in coherence with the chemical properties of the other halogens, and also possesses a more metallic character that explains the existence of stable cationic species. The objective in this work is to identify the properties of different At species in aqueous solution. The predominance of the species At− in reducing acidic conditions was confirmed by means of a technique of electromobility. A first value of absolute mobility is then proposed. In more oxidizing conditions, the species At+ dominates. The reactivity of this species with the ions of the halogens series was studied/quantified. An exotic species IAtBr− was highlighted in particular thanks to the help of modeling tools. The peculiarity of the compound AtI to form halogen-type bonds was shown for the first time
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Guérard, François. "Nouvelle méthode de radiomarquage des anticorps à l'astate-211 hypervalent pour la radioimmunothérapie alpha des cancers." Nantes, 2010. https://archive.bu.univ-nantes.fr/pollux/show/show?id=55d1b24d-6cbb-4198-af40-b3764c525301.

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L'astate-211 est un radionucléide émetteur de particules alpha très prometteur pour la thérapie des cancers. Associé à un vecteur immunologique adapté, il pourrait permettre le traitement de différents types de micrométastases ou de cancers résiduels. Cependant, le manque de stabilité des méthodes de radiomarquage des anticorps avec ce radionucléide est un frein au développement d'applications cliniques. Ces travaux ont eu pour but la mise au point d'une nouvelle méthode de radiomarquage des anticorps à l'astate-211. La spécificité de cette méthode est d’utiliser pour la première fois l'astate-211 sous forme hypervalente. Des précurseurs stanniques ont été conçus pour permettre l'introduction de l'astate-211 sous une forme trivalente stabilisée. L'étude de faisabilité du radiomarquage des anticorps par cette méthode ainsi que les tests de stabilité préliminaires ont également été réalisés
Astatine-211 is a promising alpha emitter for the therapy of cancers. In association with a suited immunologic carrier, it could allow the treatment of some micrometastasis or residual cancer diseases. However, the lack of stability of the radiolabelling of the antibodies with this radionuclide is a limitation for the development of clinical applications. This work describes a new approach for the radiolabelling of the antibodies with astatine-211. The specificity of this method is the use for the first time of hypervalent astatine. Tin precursors were designed to allow the introduction of astatine-211 under a stabilised trivalent state. The feasibility study of the radiolabelling of the antibodies with this method and the preliminary stability assesments are also described
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Lindegren, Sture. "Astatine-211 and iodine conjugates : radiohalogenation and preclinical pharmacokonetics for targeted and pretargeted radioimmunotherapy /." Göteborg : Chalmers Univ. of Technology, 2002. http://www.gbv.de/dms/bs/toc/348722176.pdf.

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Sergentu, Dumitru-Claudiu. "Géométries, electronic structures, and physico-chemical porperties of astatine species : an application of relativistic quantum mechanics." Thesis, Nantes, 2016. http://www.theses.fr/2016NANT4024/document.

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Les tentatives menées pour détruire des cellules cancéreuses avec les agents radiothérapeutiques à base de 211 At qui ont été synthétisés jusqu’à présent ne sont pas encore pleinement satisfaisantes car elles sont entachées par une deastatination in vivo. Étant donné que ce problème est lié aux connaissances actuelles qui sont limitées concernant la chimie de base de l’astate et de ses espèces, des recherches fondamentales combinant des expériences à l’échelle des ultra-traces et des études théoriques ont été lancées. Dans cette thèse, une étude théorique de plusieurs espèces de l’astate est réalisée au moyen de méthodes relativistes basées sur la théorie de la fonctionnelle de la densité ou des méthodes à basées sur la fonction d’onde. Tout d'abord, les méthodes qui peuvent être utilisées pour faire des prédictions pertinentes sont établies. A l’aide de ces approches, nous rationaliserons les structures électroniques, géométries et propriétés physicochimiques des différents systèmes d'intérêt théorique ou expérimental, en particulier les espèces AtF3 et AtO+. Finalement, nous identifierons formellement une nouvelle espèce de l’astate à l’aide de résultats expérimentaux et de calculs, ce qui non seulement complète le diagramme de Pourbaix de l’astate en milieu aqueux non complexant, mais aussi donne des informations cruciales pour identifier des conditions expérimentales pour rendre le plus « réactif » possible le précurseur At−, qui est de nos jours impliqué dans la synthèse d’agents radiothérapeutiques innovants
Trials to destroy cancer cells with currently synthesized 211 At-based radiotherapeutic agents are not yet fully satisfactorily since they resume to in vivo deastatination. Since this issue is related to the limited knowledge of the basic chemistry of At and its species, fundamental researches combining ultra-trace experiments and computational studies have been initiated. In this thesis, a computational study of several At species is performed, by means of relativistic density functional theory and wave-function-based calculations. First, the quantum mechanical approaches that can safely be used to make adequate predictions are established. Using these approaches, we attempt to rationalize the electronic structures, geometries, and physico-chemical properties of various systems of theoretical and/or experimental interest, in particular the AtF3 and AtO+ ones. By the end, we firmly identify a new At species by combining outcomes of experiments and calculations. This new species not only completes the Pourbaix diagram of At in aqueous and non-complexing media, but also gives clues of identifying experimental conditions to make best reactive the At– precursor, which is currently involved in the synthesis of promising radiotherapeutic agents
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Bourgeois, Mickaël. "Étude de faisabilité de Radio-Immunothérapie alpha à l'astate-211." Nantes, 2009. https://archive.bu.univ-nantes.fr/pollux/show/show?id=451eb856-6a13-4712-9592-273f054a9531.

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La radio-immunothérapie alpha est une thérapie anticancéreuse prometteuse qui consiste à vectoriser des radionucléides émetteurs de particules alpha à l'aide d'agents immunospécifiques de certaines tumeurs afin de les détruire. La première partie de ce travail présente les différentes caractéristiques conditionnant la réussite de la radio-immunothérapie en replaçant cette approche thérapeutique originale dans l'arsenal anti-cancéreux. Au cours de ces dernières années, l'astate-211 est apparu comme l'un des isotopes émetteurs de particules alpha les plus intéressants, l'ensemble des caractéristiques chimiques, physiques, biologiques ainsi que les différents essais de couplage à des immunovecteurs sont analysés dans cette partie. La seconde partie de ce mémoire a pour but d'évaluer la faisabilité de marquage d'une structure protéique de type immunovecteur (immunoglobuline entière ou fragment de type F(ab’)2) avec de l'astate-211 produit par irradiation cyclotron et extrait de sa cible par une voie originale d'extraction liquide (attaque par de l'acide nitrique). Cette étude expérimentale à permis d'optimiser ce type de marquage en vue d'obtenir un immunovecteur fonctionnel et suffisamment stable in vivo pour envisager une étude pré-clinique
Alpha radio-immunotherapy is a promising cancer therapy that uses alpha-particles vectorized by monoclonal antibody to break down cancerous tumours. The first part of this work presents the different factors that affect the success of radio-immunotherapy in cancer treatment. Specifically we concentrate on astatine-211, an α particle emitting isotope that has shown great promise for cancer treatment. The differents studies of the immuno-vectorisation of this isotope are also presented in this section. The second part of this thesis aims to evaluate the feasibility of immunoglobulin labelling (full or F(ab')2 fragment) with astatine-211. The labelling took place using a cyclotron irradiation to produce astatine-211 which was subsequently extracted by treating the target with nitric acid. This experimental study allowed us to optimize the labelling process to an in vivo stable immunoglobin labelled with astatine-211 such that a pre-clinical study is plausible
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Berdal, Marion. "Exploration de nouvelles voies de radiomarquage avec l’astate-211 sous forme nucléophile : application à la préparation de radioimmunoconjugués pour la thérapie alpha vectorisée des cancers." Thesis, Nantes, 2020. http://www.theses.fr/2020NANT1021.

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L’astate-211 est un radionucléide prometteur pour la thérapie alpha vectorisée des cancers. Cependant, les méthodes actuelles de radiomarquage d’anticorps avec ce radiohalogène présentent de nombreuses limites telles que des rendements non-optimaux ou l’utilisation de précurseurs toxiques, ce qui complique son transfert en clinique. Afin de proposer des alternatives plus viables, l’exploration de nouvelles classes de précurseurs permettant le radiomarquage avec l’astate-211 et l’iode-125 sous forme nucléophile a été menée. Dans un premier temps, la synthèse de composés modèles pour chacune de ces classes et leur comparaison en termes d’efficacité a été réalisée afin d’identifier les plus adaptées pour le radiomarquage avec ces deux radionucléides. Dans une deuxième partie, la faisabilité d’un radiomarquage d’anticorps à l’astate-211 et à l’iode-125 en une seule étape, utilisant les acides arylboroniques, a été investigué. Dans un premier temps, l’étude de réactivité sur un composé modèle simple a été effectuée afin d’identifier des conditions efficaces en milieu aqueux et à basse température avant de transférer cette approche à un anticorps anti- CD138 d’intérêt pour le ciblage du myélome multiple. Le nouveau procédé ainsi développé surpasse les autres méthodes rapportées dans la littérature et a été validé par des études précliniques de biodistributions. Cette nouvelle méthode de radiomarquage devrait faciliter le passage de l’astate-211 en clinique et permettre le développement d’outils théranostiques basés sur la paire astate/iode
Astatine-211 is a promising radionuclide for targeted alpha therapy of cancers. However, current approaches to bind this radiohalogen to an antibody exhibit limitations such as suboptimal radiochemical yields or the use of toxic precursors, which complicates its clinical transfer. In order to find better alternatives, we explored new classes of precursors, which allow the radiolabelling with astatine-211 and iodine-125 in their nucleophilic form. First, the synthesis of model compounds for each class and the comparison of their efficiency were performed to identify the most promising ones for the radiolabelling with both radionuclides. In a second part, the feasibility of the one-step radiolabelling of antibodies with astatine-211 and iodine-125 using arylboronic acids has been investigated. First, the study on a model compound was conducted in order to identify efficient conditions in aqueous medium and at low temperature before transfering this approach to an anti-CD138 antibody of interest for targeting multiple myeloma. The new process developped outperforms others methods reported in the litterature and has been validated in preclinical biodistribution studies. This new radiolabelling method will ease the clinical transfer of astatine-211 as well as the development of theranostic tools based on the astatine/iodine pair
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Books on the topic "Astature"

1

Berei, Klara, Siegfried H. Eberle, H. W. Kirby, Helmut Münzel, Kurt Rössler, Arnulf Seidel, and László Vasáros. At Astatine. Edited by Hans Karl Kugler and Cornelius Keller. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8.

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Sims, H. E. ²¹¹At and ⁹⁰Y: Two nuclides for potential use in tumour therapy : production at Harwell Laboratory. Oxfordshire: Chemistry Division, Harwell Laboratory, 1986.

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Kenyon, Michael. Astatine. Brick Books Incorporated, 2014.

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Keller, Cornelius, and Hans K. Kugler. At Astatine. Springer, 2013.

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Roza, Greg. Halogen Elements Fluorine, Chlorine, Bromine, Iodine, Astatine. Rosen Publishing Group, 2010.

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Zegeye, Abebe. Mulatu Astatke: The Making of Ethio Jazz. Africa World Press, 2022.

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DeCarlo, Raymond A. Linear systems: Astate variable approach with numerical implementation. Prentice-Hall International, 1989.

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(Firm), Universal Map. Lake County, Florida, StreetMap: Including Astatula, Clermont, Eustis ... Umatilla & neighboring communities. UniversalMAP, 1999.

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(Firm), Universal Map. Lake County, Florida, StreetMap: Including Astatula, Clermont, Eustis ... Umatilla & neighboring communities. UniversalMAP, 2000.

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Astatula Flor State of Mind Collection. Sudoku Genius Mind Exercises Volume 1: Astatula, Florida State of Mind Collection. Independently Published, 2019.

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Book chapters on the topic "Astature"

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Kirby, H. W. "History." In At Astatine, 1–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_1.

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Eberle, S. H., Klara Berei, and László Vasáros. "Chemical Behavior and Compounds of Astatine." In At Astatine, 183–289. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_10.

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Kirby, H. W. "Natural Occurrence." In At Astatine, 10–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_2.

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Münzel, H. "Nuclear Properties of Astatine Isotopes." In At Astatine, 15–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_3.

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Kirby, H. W., and K. Rössler. "Production, Isolation, and Purification of Astatine Isotopes." In At Astatine, 95–106. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_4.

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Vasáros, László, and Klara Berei. "General Properties of Astatine." In At Astatine, 107–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_5.

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Kirby, H. W. "Analytical Chemistry of Astatine." In At Astatine, 129–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_6.

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Rössler, K. "Handling of Astatine." In At Astatine, 140–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_7.

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Seidel, Arnulf. "Astatine in Biology and Nuclear Medicine." In At Astatine, 157–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_8.

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Rössler, Kurt. "Irradiation and Self-Irradiation of Astatine Compounds." In At Astatine, 179–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_9.

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Conference papers on the topic "Astature"

1

Jakobsson, U., J. Uusitalo, K. Auranen, H. Badran, B. Cederwall, D. M. Cox, T. Grahn, et al. "Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei." In Nuclear Structure and Dynamics ’15. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4932258.

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Takashima, Hiroki, Yoshikatsu Koga, Kazunobu Onuki, Shino Manabe, Ryo Tsumura, Takahiro Anzai, Nozomi Iwata, et al. "Abstract 2863: Preclinical evaluation of astatine-211-conjugated anti-tissue factor antibody." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2863.

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Uusitalo, J., U. Jakobsson, and Bertram Blank. "Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line." In THE 4TH INTERNATIONAL CONFERENCE ON PROTON EMITTING NUCLEI AND RELATED TOPICS. AIP, 2011. http://dx.doi.org/10.1063/1.3664144.

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Takai, Toshihide, Tomohiro Furukawa, Shigeki Watanabe, and Noriko S. Ishioka. "Corrosion Behavior of Iron-Chrome Alloys in Liquid Bismuth." In 2021 28th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icone28-63277.

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Abstract For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, the National Institute for Quantum and Radiological Science and Technology has proposed the innovative “Liquid Bismuth Target System.” The target window in this system must be made from a material that resists the highly corrosive liquid bismuth environment. To meet this requirement, a promising target window material was selected in corrosion experiments performed in stagnant liquid bismuth. Based on knowledge of corrosion in liquid lead–bismuth eutectic gained during the development of fast reactors and accelerator-driven subcritical systems, FeCrMo–alloy, FeCrAl–alloy, and austenitic stainless steel (as a reference) were selected as the specimen materials. Experiments were carried out under saturated dissolved oxygen and low oxygen conditions, and the corrosion behaviors of the specimens were evaluated, mainly by scanning electron microscopy. The FeCrAl–alloy exhibited the most excellent corrosion resistance, followed by FeCrMo–alloy. Both materials are suitable candidates for the target window. Although austenitic stainless steel was less corrosion resistant than the former two materials, it is a likely applicable for the target window under appropriately limited operation conditions (such as irradiation current and exposure time) of the liquid bismuth target system.
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Reports on the topic "Astature"

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Ruth, T. J., M. Dombsky, J. M. D'Auria, and T. E. Ward. Radiochemistry of astatine. Office of Scientific and Technical Information (OSTI), January 1988. http://dx.doi.org/10.2172/6748269.

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Wilbur, Daniel. Automated Isolation of Astatine-211 and Chemistry Evaluation. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1651207.

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Mach, Robert, Hsiaoju Lee, Mehran Makvandi, Sean Reilly, Ho Sze Chan, Paul Martorano, and David Schaub. Production of Astatine-211 for Translational Science in Radiotherapy. Office of Scientific and Technical Information (OSTI), March 2024. http://dx.doi.org/10.2172/2329303.

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Wilbur, D. S. Pretargeting of Astatine-211 for Therapy of Metastic Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada374830.

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Lapi, Suzanne E. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1575920.

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Ellison, Paul, Jonathan Engle, Aeli Olson, Todd Barnhart, Robert Nickles, Sabrina Hoffman, Dhanabalan Murali, Onofre DeJesus, and Bryan Bednarz. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), January 2020. http://dx.doi.org/10.2172/1682261.

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Mach, Robert. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1839290.

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Wilbur, Daniel Scott. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators". Office of Scientific and Technical Information (OSTI), December 2012. http://dx.doi.org/10.2172/1124492.

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MICHAEL R. ZALUTSKY. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS. Office of Scientific and Technical Information (OSTI), August 2012. http://dx.doi.org/10.2172/1047758.

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Zalutsky, Michael. Production of Astatine-211 at the Duke University Medical Center for its regional distribution. Office of Scientific and Technical Information (OSTI), January 2016. http://dx.doi.org/10.2172/1233560.

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