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Academic literature on the topic 'Astatide'

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Published: 25 May 2024

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "Astatide":

1

Garkushin, Ivan K., Olga V. Lavrenteva, Yana A. Andreeva, and Karina R. Gilmanova. "Analytical description of the specific electric conductivity of halogenides KHal melts and its calculation for the KAt melt." Butlerov Communications 58, no. 6 (June 30, 2019): 138–45. http://dx.doi.org/10.37952/roi-jbc-01/19-58-6-138.

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In this paper, the analytical description of the specific conductivity of the potassium halogenides melts KHal (Hal – F, Cl, Br, I) is presented. The analitical description is provided on dependence of the specific conductivity on the halogen order number ӕ = f(Z), the ionic radius of halogen-ion ӕ = f(r), the ionic potential ӕ = f(1/r), the electronegativity difference ӕ = f(∆χ) ((∆χ = χ (Hal) – χ(K)). The interrelation of a reduced property with an order number ӕ/Z = f(Z) is considered. According to the obtained analytical dependencies, the calculation of the value of the potassium astatide specific conductivity is given for temperatures above the melting point on 5, 10, 50, 75, 100, 150 и 200°, in literature Information for KAt absent. The calculation was carried out using comparative methods for calculating M.Kh. Karapetyan in the coordinates of "property-parameter" and "property-property." Least squares method was applied for processing the analytical description results with the choice of optimal dependencies on the maximum correlation coefficient and the minimum standard deviation. The analysis of the interrelation of the calculated numerical values with similar characteristics for NaAt и LiAt is presented. Comparison of the specific conductivity obtained numerical values of the astatide potassium melt showed good consistency with the values ӕ obtained from the straight line dependence ӕТпл+n = a∙ ӕТпл+5 (n = 10°…200°) and also with similar characteristics for lithium astatide and sodium astatide. The analytical calculation results allow to describe the temperature dependence of the potassium halogenides specific conductivity, including KAt. The calculation method can be used to describe the melts specific conductivity in the same type series of compounds of alkaline and alkaline-earth elements that make up electrolytes for chemical current sources.
2

Baran, Enrique J. "Vibrational Properties of Hydrogen Astatide, HAt." Zeitschrift für Naturforschung A 59, no. 3 (March 1, 2004): 133–35. http://dx.doi.org/10.1515/zna-2004-0306.

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A number of theoretical studies on the bond characteristics of HAt, the heaviest hydrogen halide, have recently been reported. On the basis of these data the force constant, mean amplitudes of vibration and thermodynamic functions of this molecule have been calculated. Some comparisons with the related lighter hydracids are made.
3

Pruszyński, M., A. Bilewicz, B. Wąs, and B. Petelenz. "Formation and stability of astatide-mercury complexes." Journal of Radioanalytical and Nuclear Chemistry 268, no. 1 (April 2006): 91–94. http://dx.doi.org/10.1007/s10967-006-0129-2.

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4

Wilbur, D. "[211At]Astatine-Labeled Compound Stability: Issues with Released [211At]Astatide and Development of Labeling Reagents to Increase Stability." Current Radiopharmaceuticalse 1, no. 3 (September 1, 2008): 144–76. http://dx.doi.org/10.2174/1874471010801030144.

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Styszyński, Jacek, and Jacek Kobus. "Relativistic and correlation effects on spectroscopic constants of the hydrogen astatide molecule." Chemical Physics Letters 369, no. 3-4 (February 2003): 441–48. http://dx.doi.org/10.1016/s0009-2614(02)02014-6.

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Larsen, Roy H., Susan Slade, and Michael R. Zalutsky. "Blocking [211At]Astatide Accumulation in Normal Tissues: Preliminary Evaluation of Seven Potential Compounds." Nuclear Medicine and Biology 25, no. 4 (May 1998): 351–57. http://dx.doi.org/10.1016/s0969-8051(97)00230-8.

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Carlin, Sean, Robert J. Mairs, Phil Welsh, and Michael R. Zalutsky. "Sodium-iodide symporter (NIS)-mediated accumulation of [211At]astatide in NIS-transfected human cancer cells." Nuclear Medicine and Biology 29, no. 7 (October 2002): 729–39. http://dx.doi.org/10.1016/s0969-8051(02)00332-3.

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Garkushin, Ivan K., Olga V. Lavrenteva, Karina R. Gilmanova, and Yana A. Andreeva. "Analytical description of sodium halogenides melts specific electric conductivity and its calculation for sodium astatide melt." Butlerov Communications 60, no. 12 (December 31, 2019): 125–32. http://dx.doi.org/10.37952/roi-jbc-01/19-60-12-125.

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The paper presents analytical and graphical dependences of the individual haloganides melts specific electrical conductivity æ of the sodium NaHal series (Hal – F, Cl, Br, I) on the halogen order number Z, ionic radius r of haloganide-ion Hal–, halogen ionic potential 1/r, reduced ionic radius r/Z, difference of electronegativity (∆χ = χ(Hal) – χ(Na)): æ = f(Z); æ = f(r); æ = f(1/r); æ = f(r/Z); æ = f(∆χ) for the temperature higher melting temperatures on 5, 10, 50, 75, 100, 150 и 200°. M.Kh. Karapetyans сomparative methods were applied for the description. The minimum standard deviation and maximum correlation coefficient corresponds to the equation æ–1 = a + bexp1/r, according to which the numerical values of æ(NaAt) are calculated for real temperatures. The temperature dependence æ of the NaAt melt is described by the equation æ = 0.0508+0.0023Т. A comparative analysis of the relationship between the specific electrical conductivity of NaHal melts at a temperature of Tm + n (n = 10 ... 200° higher the melting temperature) and æ at (Tm + 5°). A comparative analysis is represented by straightforward dependencies. It was shown that the specific electrical conductivity of the NaAt melt is related to the electrical conductivity of LiAt by the direct equation æ(NaAt) = 0.035+0.607æ(LiAt). The straight line equationalso relates æ of the NaHal melt (Hal – F, Br, I, At) to the specific conductivity of the NaCl melt. Between the numerical values of the specific electrical conductivity of the sodium astatide (NaAt) melt calculated by different methods, consistent data were obtained.
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Watabe, Tadashi, Makoto Hosono, Seigo Kinuya, Takahiro Yamada, Sachiko Yanagida, Masao Namba, and Yoshihide Nakamura. "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)." Annals of Nuclear Medicine 35, no. 7 (May 12, 2021): 753–66. http://dx.doi.org/10.1007/s12149-021-01619-2.

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AbstractWe present the guideline for use of [211At] sodium astatide (NaAt) for targeted alpha therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported by the Ministry of Health, Labour, and Welfare, and approved by the Japanese Society of Nuclear Medicine on 8th Feb, 2021. The study showed that patients receiving [211At]NaAt do not need to be admitted to a radiotherapy room and outpatient treatment is possible. The radiation exposure from the patient is within the safety standards of the ICRP and IAEA recommendations for the general public and caregivers. Precautions for patients and their families, safety management associated with the use of [211At]NaAt, education and training, and disposal of medical radioactive contaminants are also included in this guideline. Treatment using [211At]NaAt in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection and evaluation methodology shown here are considered internationally useful as well.
10

Rimár, Miroslav, Marcel Fedák, and Štefan Kuna. "Equation Model of Stabilization of Low Damped Astatic Systems." Applied Mechanics and Materials 415 (September 2013): 427–30. http://dx.doi.org/10.4028/www.scientific.net/amm.415.427.

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The paper deals with the stabilization of low damped astatic systems. They show a low value of a relative damping and consequently a high resonance rise of amplitude frequency response. If astatism occurs in an automatic control system, the situation becomes complicated due to the exhaustion of a phase safety of astatic element. In order to achieve the stabilization, a filter with rejections has been designed. The filter is characterized by rapid rejections of logarithmic frequency characteristics that eliminate resonance rise of a low damped astatic system. A functional model of a discrete filter was created to attest the properties of the filter with a continuous low damped astatic system. Experiments have proved the suitability of the filter application. The method of the filter utilization, the stability of the low damped astatic system as well as the stability assessment by the operator W will be described in the paper.
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Journal articles Dissertations / Theses Books

Dissertations / Theses on the topic "Astatide":

1

Desiree, Patrick R. "Synthèse et développement de macrocycles pour la capture d'anions d'intérêt thérapeutique." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0152.

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La chimie supramoléculaire consiste en l’assemblage par des interactions non-covalentes d’architectures moléculaires plus ou moins complexes. A l’état naturel, ces édifices remplissent de nombreuses fonctions telle que le support génétique par la molécule d’ADN. Les anions peuvent aussi être impliqués au niveau radiothérapeutique par le biais de l’iodure. Par opposition, ce même élément peut être associé à certaines catastrophes environnementales (explosion de Fukishima, 2011) voire à certaines pathologies (thyroïdopathie). Face aux problématiques citées, il est donc primordial de développer des outils permettant de lutter face à ces évènements désastreux. Les travaux présentés ici consistent en l’élaboration de macrocycles de type boronium pouvant piéger de manière efficace l’iodure, anion modèle pour l’étude de la capture de l’astature et encore peu connu, en raison de son faible temps de demi-vie. Cette coordination s’effectue par une collaboration de liaisons hydrogène et d’interactions ioniques. Sur la base des travaux antérieurs réalisés au laboratoire, il a été question d’étudier de manière approfondie les propriétés de complexation des cages synthétisées, les Calix-carBIB. Dans un deuxième temps, de nouveaux groupements fonctionnels ont été utilisés afin d’étudier leur potentiel pour différentes applications, notamment pour la purification de l’astature ou encore la vectorisation. Enfin, une nouvelle génération de récepteurs a été étudiée, présentant en théorie une affinité plus importante pour l’astature
Supramolecular chemistry consists of molecular architecture complex organized thanks to a combination of non-covalent interactions. At the natural state, these structures have numerous functions such as cell energy production thanks to the ATP synthase or the genetic support thanks to a polyanion, the DNA molecule. Anions can be involved in radiotherapy through iodide. By opposition, it can also be associated with environmental disasters (Fukushima explosion in 2011) or some diseases (thyroid disease). In front of these troubles, it is a priority to fight against theses disastrous events. This PhD work has focused on the construction of boronium type macrocycle able to strongly trap iodide which is an anion model to study astatide trapping. This coordination is done thanks to hydrogen bonding and ionic interactions collaboration. Based on previous works realized in our laboratory in 2010, complexation properties of Calix-carBIB were studied. In a second time, new functionalized groups were used to study their potential for different applications such as astatide purification, water solubility and vectorization. Finally, a new receptor generation was studied, showing a better affinity for astatide
2

Liu, Lu. "Exploration de la chimie de l'astate en solution : focalisation sur le diagramme de Pourbaix en milieu non complexant et caractérisation de liaisons halogènes induites par l'astate." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2020. http://www.theses.fr/2020IMTA0205.

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L'astate (At, Z = 85) est un élément halogène rare, tous ses isotopes étant radioactifs. En raison des quantités disponibles limitées, aucun outil spectroscopique n'est applicable pour identifier la nature moléculaire des espèces d'At. En conséquence, la chimie de l'At reste méconnue. L'un de ses isotopes, ²¹¹At, est un candidat potentiel pour le traitement de cancers par thérapie alpha ciblée. Cependant, la connaissance limitée de ses propriétés chimiques a entravé les tentatives de marquage de ²¹¹At avec des molécules porteuses ciblant la maladie. Cela a conduit au développement d’un programme de recherches sur la chimie de base de At. Cette thèse s’intéresse plus particulièrement au diagramme de Pourbaix de l’astate et à la caractérisation de liaisons halogènes avec l’espèce AtI, au moyen de divers outils expérimentaux (chromatographie ionique, méthode de compétition et électromobilité). Dans une première partie, des études de spéciation de At en milieu alcalin confirment la présence de l'espèce At⁻ en conditions réductrices. Lorsque le potentiel augmente, l’espèce AtO(OH)₂⁻ se forme. Le changement de spéciation entre ces deux espèces est décrit pour la première fois. Dans une deuxième partie, la formation de liaisons halogènes entre l'espèce AtI et divers composés organiques a été étudiée. La réactivité se résume par une échelle de basicité nouvellement établie dont la force entre le donneur (AtI) et l’atome accepteur varie suivant l’ordre C ≤ O ≤ S (≈ Se)
Astatine (At, Z = 85) is a scarce halogen element, all of its isotopes being radioactive. Due to the limited available quantities, no spectroscopic tool is applicable to identify the molecular nature of At species. Consequently, the chemistry of At remains poorly known. One of its isotopes, ²¹¹At, is a potential candidate for the treatment of cancers by targeted alpha therapy. However, the limited knowledge of its chemical properties has hindered attempts to label ²¹¹At with disease targeting carrier molecules. This led to the development of a research program on the basic chemistry of At. This thesis focuses more particularly on the Pourbaix diagram of astatine and the characterization of halogen bonds with the AtI species, by means of various experimental tools (ion chromatography, competition method and electromobility). In the first part, speciation studies of At in alkaline medium confirm the presence of the At⁻ species under reducing conditions. As the potential increases, the AtO(OH)₂⁻ species is formed. The speciation change between these two species is described for the first time. In a second part, the formation of halogen bonds between the AtI species and various organic compounds was studied. The reactivity is summarized by a newly established basicity scale, with the strength between the donor (AtI) and the acceptor atom following the order of C≤ O ≤ S (≈ Se)
3

Da, Silva I., T. Sauvage, P. Rifard, F. Durand, J. P. Trasbot, and N. Michel. "Evolution of production of Astatine-211 in Orléans Cyclotron." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166243.

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Introduction Since 2005, we produce, at academic scale in Orleans, 211At for needs of chemistry and physicians teams of Nantes in research project of alpha immunotherapy. Between 2005 and 2014, several modifications were been made on preparation of target, targetry and radiation to protect personnel. Material and Methods The first target was a molten Bi metal onto a Cu support pre-treated with acid attack. The wished thickness (up to 100 µm) was obtained by mechanical treatment of target. The target is irradiated at 32MeV alpha particle beam for around 2 hours and then delivered by road transport to users. Only a measure of radiation dose was made to evaluate target activity. The second target we have used since 2010 is a electrodeposition of Bi (thickness of around 30 µm) onto AlN backing. We used a beam of 30.5 MeV for reaction 207Bi(α,n)211At (2 h with a current intensity of 2µA). Activity has measured with a detector Ge at 687 keV (γ-branching fraction = 0.26 %) before to be delivered. For all targets, beam energy on target was around 28.7 Mev in order not to produce too much 210At. Results and Conclusion 138 productions with the first target were delivered with an estimated activity of less than 100 MBq. Difficulties with wet extraction1, low yield of radiolabelling (metallic impurities and activation of copper resulting in 66Ga and 67Ga) made necessary to change process of extraction. With support of AlN, dry extraction was used with good yield (75–80 %) and without activation of support. Until today, 46 batchs were delivered with activity of 44 ± 12 MBq/µAh. Yield activity of 211At has been almost doubled compared to first target (25MBq/µAh). The dose burden to personnel was decreased with modification of targetry (outside of blockhouse of cyclotron, in a specific line beam to radionuclide production, cf. FIG. 1). In the case of 211At production, energy of reaction is of major impact. With our versatile accelerator (range of energy in alpha between 10 and 50 MeV) and a low thickness of metal, it’s easy to reach the right energy. This radionuclide production will be continued until ARRONAX, Nantes cyclotron, could take over from us for bigger activity of 211At.
4

Lindegren, Sture. "Astatine-211 and iodine conjugates : radiohalogenation and preclinical pharmacokonetics for targeted and pretargeted radioimmunotherapy /." Göteborg : Chalmers Univ. of Technology, 2002. http://www.gbv.de/dms/bs/toc/348722176.pdf.

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5

Sergentu, Dumitru-Claudiu. "Géométries, electronic structures, and physico-chemical porperties of astatine species : an application of relativistic quantum mechanics." Thesis, Nantes, 2016. http://www.theses.fr/2016NANT4024/document.

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Les tentatives menées pour détruire des cellules cancéreuses avec les agents radiothérapeutiques à base de 211 At qui ont été synthétisés jusqu’à présent ne sont pas encore pleinement satisfaisantes car elles sont entachées par une deastatination in vivo. Étant donné que ce problème est lié aux connaissances actuelles qui sont limitées concernant la chimie de base de l’astate et de ses espèces, des recherches fondamentales combinant des expériences à l’échelle des ultra-traces et des études théoriques ont été lancées. Dans cette thèse, une étude théorique de plusieurs espèces de l’astate est réalisée au moyen de méthodes relativistes basées sur la théorie de la fonctionnelle de la densité ou des méthodes à basées sur la fonction d’onde. Tout d'abord, les méthodes qui peuvent être utilisées pour faire des prédictions pertinentes sont établies. A l’aide de ces approches, nous rationaliserons les structures électroniques, géométries et propriétés physicochimiques des différents systèmes d'intérêt théorique ou expérimental, en particulier les espèces AtF3 et AtO+. Finalement, nous identifierons formellement une nouvelle espèce de l’astate à l’aide de résultats expérimentaux et de calculs, ce qui non seulement complète le diagramme de Pourbaix de l’astate en milieu aqueux non complexant, mais aussi donne des informations cruciales pour identifier des conditions expérimentales pour rendre le plus « réactif » possible le précurseur At−, qui est de nos jours impliqué dans la synthèse d’agents radiothérapeutiques innovants
Trials to destroy cancer cells with currently synthesized 211 At-based radiotherapeutic agents are not yet fully satisfactorily since they resume to in vivo deastatination. Since this issue is related to the limited knowledge of the basic chemistry of At and its species, fundamental researches combining ultra-trace experiments and computational studies have been initiated. In this thesis, a computational study of several At species is performed, by means of relativistic density functional theory and wave-function-based calculations. First, the quantum mechanical approaches that can safely be used to make adequate predictions are established. Using these approaches, we attempt to rationalize the electronic structures, geometries, and physico-chemical properties of various systems of theoretical and/or experimental interest, in particular the AtF3 and AtO+ ones. By the end, we firmly identify a new At species by combining outcomes of experiments and calculations. This new species not only completes the Pourbaix diagram of At in aqueous and non-complexing media, but also gives clues of identifying experimental conditions to make best reactive the At– precursor, which is currently involved in the synthesis of promising radiotherapeutic agents
6

Guo, Ning. "Investigation of the chemical properties of astatine at +I and –I oxydation states in aqueous solution." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT4038/document.

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La thérapie alpha ciblée est une technique prometteuse pour le traitement de cancers. L’astate-211, de temps de demi-vie de 7,21 h, est considéré comme un candidat prometteur pour cette application. Une condition pré-requise est de fixer de manière stable l’isotope radioactif sur le vecteur qui va servir à reconnaitre les cellules malades. Ceci demande une connaissance approfondie des propriétés chimiques de l’astate. Compte tenu de sa position dans le tableau périodique des éléments, l’astate peut exister sous la forme At− en cohérence avec les propriétés chimiques des autres halogènes, et possède aussi un caractère plus métallique qui explique l’existence d’espèces cationiques stables. L’objectif de cette thèse est d’identifier et d’étudier les propriétés des différentes espèces de l’astate en solution aqueuse. La prédominance de l’espèce At− en milieu acide réducteur a été confirmée au moyen d’une technique d’électromobilité. Une première valeur de mobilité absolue est ainsi proposée. En milieu plus oxydant, l’espèce At+ domine. La réactivité de cette espèce avec les ions de la série des halogènes a été étudiée/quantifiée. Une espèce exotique IAtBr− a notamment été mise en évidence grâce à l’aide d’outils de modélisation moléculaire. La particularité du compound AtI à former des liaisons de type halogène a été montrée pour la première fois
Targeted alpha therapy is an appealing method for the treatment of cancer as a complement to the current approaches. Astatine-211, with a half-life of 7.21 h, is considered as an exciting prospective candidate for this application. A pre-required condition is to fix in a stable way the radioactive isotope to the vector that is going to serve to recognize cells. This asks for a thorough knowledge of the chemical properties of astatine. Considering its position in the periodic table, it can exist under the form At− in coherence with the chemical properties of the other halogens, and also possesses a more metallic character that explains the existence of stable cationic species. The objective in this work is to identify the properties of different At species in aqueous solution. The predominance of the species At− in reducing acidic conditions was confirmed by means of a technique of electromobility. A first value of absolute mobility is then proposed. In more oxidizing conditions, the species At+ dominates. The reactivity of this species with the ions of the halogens series was studied/quantified. An exotic species IAtBr− was highlighted in particular thanks to the help of modeling tools. The peculiarity of the compound AtI to form halogen-type bonds was shown for the first time
7

Tang, Shan. "Expanding the phenotype and genetic spectrum of myoclonic astatic epilepsy." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/expanding-the-phenotype-and-genetic-spectrum-of-myoclonic-astatic-epilepsy(991de1f3-e1a5-49d7-b68a-43abb859fb39).html.

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Myoclonic astatic epilepsy (MAE) is a rare generalised childhood epilepsy with variable but poorly described neurodevelopmental outcome. Family studies suggest a major genetic influence as up to two thirds of relatives have seizures, or electroencephalographic (EEG) abnormalities. MAE is associated with 10 different genes, yet these genes account for less than 20% of the genetic aetiology of MAE leaving the majority unexplained. The aims of this thesis were (1) describe the epilepsy and neurodevelopmental phenotype of MAE cases, (2) perform EEG studies on first degree family members for familial EEG abnormalities and compare occurrence of epileptiform features to population prevalence and (3) to collect DNA and identify MAE causative genetic variants through exome sequencing. I assembled the largest MAE cohort (n=123) to date. The epilepsy phenotype is remarkably similar to previously published cohorts. I identified a severe neurodevelopmental phenotype: intellectual disability was reported in 64.9%, autism spectrum disorder in 21.3% and attention deficit hyperactivity symptoms in 41.0%. Additionally, extremely low adaptive behavioural scores were identified in 69.4% of cases. I performed EEG studies on 38 first-degree relatives of 13 MAE families, and found an excess of epileptiform EEG features in adults (>16 years), compared to controls (P=0.05, RR 6.82). I identified likely pathogenic or candidate variants in 11 of 109 cases. This comprised known genes associated with MAE: CHD2 n=1, SYNGAP1 n=2, SLC6A1 n=1, KIAA2022 n=1; epilepsy associated genes novel for MAE: KCNB1 n=1, MECP2 n=1, KCNH5 n=1, and three new candidate genes; SMARCA2 n=1, ASH1L n=1 and CHD4 n=1. Lastly, I highlight phenotypic features which help correlate with known and novel specific gene associations, discuss that MAE is a phenotypic and genetic nosological bridge between genetic generalised epilepsy and epileptic encephalopathy, and discussion applications and future directions leading on from this project.
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Champion, Julie. "Exploration du caractère métallique de l'astate en solution aqueuse." Nantes, 2009. http://www.theses.fr/2009NANT2086.

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L'alpha-radiothérapie est une technique particulièrement innovante de thérapie des cancers, tout en étant complémentaire des thérapies déjà existantes. Elle repose sur l'utilisation d'un vecteur spécifique (anticorps ou peptide) de la cellule cible à détruire,radiomarqué » par un élément radioactif émetteur alpha. L'astate 211 est un candidat particulièrement intéressant compte tenu de l'énergie des particules  qu'il émet et de sa période physique (7,2 h). L'une des voies de marquage envisagée est l'utilisation de l'astate à un degré d'oxydation supérieur à zéro en tant que cation. En effet, l'astate est supposé présenter un caractère plus métallique que les autres halogènes du fait de son positionnement dans le tableau périodique. Cette voie de marquage a été peu abordée dans la littérature en raison du manque de données sur la chimie de l'astate aux degrés d'oxydation supérieurs à zéro. Le but de ce travail était donc d'explorer cette propriété de l'astate via la construction du diagramme Eh, pH (ou diagramme de Pourbaix) en milieu aqueux non complexant. Pour ce faire, ce travail s'est appuyé sur une double approche expériementale/théorique. L'approche expérimentale utilise des méthodes dites de compétition pour identifier les espèces formées et les constantes thermodynamiques des équilibres étudiés. L'approche théorique utilise des méthodes de chimie computationnelle et fournie des informations à l'échelle moléculaire sur les systèmes étudiés afin de prédire les données thermodynamiques qui servent de support et complément à l'approche expérimentale. Un résultat important de ce travail montre la présence de deux espèces cationiques stables de l'astate en solution aqueuse, At+ et AtO+
Alpha-radiotherapy is an innovative technique for the treatment of cancers complementary to current approaches. The principle is to use tumor-specific vectors labeled with alpha-radioisotopes. Astatine 211 is a very promising candidate if one considers the energy of the  particles emitted as well as its physical half-life (7. 2 h). One of the ways of labeling is to use astatine at a higher oxidation state as a « metal cation ». Indeed, considering its location in the periodic table, astatine is supposed to present a more metallic character than the other halogens. This way of labeling has however never been explored. This can be explained by the fact that the astatine chemistry is nearly unknown. The purpose of this work was therefore to explore this property of astatine and to define its Eh, pH diagram (or Pourbaix diagram) in non complexing aqueous solution. To this end, both experimental and theoretical approaches were used. The experimental approach uses competition methods to identify the formed species and the thermodynamics constants of studied equilibria. The theoretical approach uses methods of computational chemistry and provides information at the molecular scale on the studied systems in order to predict thermodynamic data which are used as support and complement to the experimental approach. The important result of this work shows the presence of two stable cationic forms of astatine in aqueous solution, i. E;, At+ and AtO+
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Guérard, François. "Nouvelle méthode de radiomarquage des anticorps à l'astate-211 hypervalent pour la radioimmunothérapie alpha des cancers." Nantes, 2010. https://archive.bu.univ-nantes.fr/pollux/show/show?id=55d1b24d-6cbb-4198-af40-b3764c525301.

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L'astate-211 est un radionucléide émetteur de particules alpha très prometteur pour la thérapie des cancers. Associé à un vecteur immunologique adapté, il pourrait permettre le traitement de différents types de micrométastases ou de cancers résiduels. Cependant, le manque de stabilité des méthodes de radiomarquage des anticorps avec ce radionucléide est un frein au développement d'applications cliniques. Ces travaux ont eu pour but la mise au point d'une nouvelle méthode de radiomarquage des anticorps à l'astate-211. La spécificité de cette méthode est d’utiliser pour la première fois l'astate-211 sous forme hypervalente. Des précurseurs stanniques ont été conçus pour permettre l'introduction de l'astate-211 sous une forme trivalente stabilisée. L'étude de faisabilité du radiomarquage des anticorps par cette méthode ainsi que les tests de stabilité préliminaires ont également été réalisés
Astatine-211 is a promising alpha emitter for the therapy of cancers. In association with a suited immunologic carrier, it could allow the treatment of some micrometastasis or residual cancer diseases. However, the lack of stability of the radiolabelling of the antibodies with this radionuclide is a limitation for the development of clinical applications. This work describes a new approach for the radiolabelling of the antibodies with astatine-211. The specificity of this method is the use for the first time of hypervalent astatine. Tin precursors were designed to allow the introduction of astatine-211 under a stabilised trivalent state. The feasibility study of the radiolabelling of the antibodies with this method and the preliminary stability assesments are also described
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Govender, Craig. "The effect of an injury prevention programme on the lower limb soft tissues in fast bowlers an intervention study." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9298_1267396646.

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The aim of the study was to determine the effect of astatic stretching programme on injury prevention. Educational pamphlets and a static stretching regime were implemented to the experimental group.

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Books on the topic "Astatide":

1

Berei, Klara, Siegfried H. Eberle, H. W. Kirby, Helmut Münzel, Kurt Rössler, Arnulf Seidel, and László Vasáros. At Astatine. Edited by Hans Karl Kugler and Cornelius Keller. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8.

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Balkt, H. H. ter. Anti-canto's en De Astatica. Amsterdam: De Bezige Bij, 2004.

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Quddus, Ishan Abd al. Asif...lam a'ud astati. Cairo: Maktaba-e-Misr, 1994.

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Sims, H. E. ²¹¹At and ⁹⁰Y: Two nuclides for potential use in tumour therapy : production at Harwell Laboratory. Oxfordshire: Chemistry Division, Harwell Laboratory, 1986.

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Qudus, Ihsan Abd Al. La astatio an ofakir wa ana arqus. Egypt: Akhbar al Yawm, 2000.

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Quddus, Ishan Abd al. La-astati an ufakkir wa ana arqus. Cairo: Maktaba-e-Misr, 1994.

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Kenyon, Michael. Astatine. Brick Books Incorporated, 2014.

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Keller, Cornelius, and Hans K. Kugler. At Astatine. Springer, 2013.

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Roza, Greg. Halogen Elements Fluorine, Chlorine, Bromine, Iodine, Astatine. Rosen Publishing Group, 2010.

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Zegeye, Abebe. Mulatu Astatke: The Making of Ethio Jazz. Africa World Press, 2022.

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Book chapters on the topic "Astatide":

1

Appelman, E. H. "In Syntheses of Hydrogen Astatide." In Inorganic Reactions and Methods, 100–101. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145159.ch59.

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Kirby, H. W. "History." In At Astatine, 1–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_1.

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Eberle, S. H., Klara Berei, and László Vasáros. "Chemical Behavior and Compounds of Astatine." In At Astatine, 183–289. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_10.

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Kirby, H. W. "Natural Occurrence." In At Astatine, 10–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_2.

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Münzel, H. "Nuclear Properties of Astatine Isotopes." In At Astatine, 15–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_3.

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Kirby, H. W., and K. Rössler. "Production, Isolation, and Purification of Astatine Isotopes." In At Astatine, 95–106. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_4.

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Vasáros, László, and Klara Berei. "General Properties of Astatine." In At Astatine, 107–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_5.

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Kirby, H. W. "Analytical Chemistry of Astatine." In At Astatine, 129–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_6.

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Rössler, K. "Handling of Astatine." In At Astatine, 140–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_7.

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Seidel, Arnulf. "Astatine in Biology and Nuclear Medicine." In At Astatine, 157–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_8.

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Conference papers on the topic "Astatide":

1

Izvoreanu, Bartolomeu, Adrian Secrieru, Ion Fiodorov, Irina Cojuhari, Dumitru Moraru, and Mihail Potlog. "Comparative analysis of the PID algorithm synthesis at the object model with astatism and dead time." In 11th International Conference on Electronics, Communications and Computing. Technical University of Moldova, 2022. http://dx.doi.org/10.52326/ic-ecco.2021/ce.02.

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The paper presents the comparative analysis of the synthesis methods of the PID tuning algorithm for the model of the object with first degree astatism and dead time. In the practice of industrial and technological process automation, mathematical models attached to processes are considered models with first degree astatism and dead time. It analyzes the methods that can be applied for tuning algorithms to these types of process models. Systems with dead time transfer elements do not have finite dimensional systemic achievements, but have an infinite number of polyzeros. In practice, these models are approximated with rational forms known as Pade approximations with minimal and non-minimal phase. The method of tuning the PID controller shall be analyzed using analytical method of maximum degree of stability and method of maximum degree of stability with iterations. In the object model the dead time component is approximated with Pade approximations with minimal phase and for these models the PID algorithm is synthesized according to the method of the maximum degree with iterations. The PID algorithm is synthesized according to the proposed methods for two examples of values of the parameters of the model of the control object with astatism and dead time and the obtained results are analyzed. The advantages of the method of maximum stability with iterations are highlighted.
2

Jakobsson, U., J. Uusitalo, K. Auranen, H. Badran, B. Cederwall, D. M. Cox, T. Grahn, et al. "Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei." In Nuclear Structure and Dynamics ’15. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4932258.

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Takashima, Hiroki, Yoshikatsu Koga, Kazunobu Onuki, Shino Manabe, Ryo Tsumura, Takahiro Anzai, Nozomi Iwata, et al. "Abstract 2863: Preclinical evaluation of astatine-211-conjugated anti-tissue factor antibody." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2863.

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Kurek, J. "Identification of inertial model for astatic system." In 2013 18th International Conference on Methods & Models in Automation & Robotics (MMAR). IEEE, 2013. http://dx.doi.org/10.1109/mmar.2013.6669995.

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Bogolyubov, Vladimir, and Lyalya Bakhtieva. "Astatic Gyrocompass Based on a Hybrid Micromechanical Gyroscope." In 2021 IEEE East-West Design & Test Symposium (EWDTS). IEEE, 2021. http://dx.doi.org/10.1109/ewdts52692.2021.9580982.

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Mejri, M. R., A. Zaafouri, and A. Chaari. "Identification and hybrid control of astation of irrigation by sprinkling." In 14th International Conference on Sciences and Techniques of Automatic Control and Computer Engineering (STA2013). IEEE, 2013. http://dx.doi.org/10.1109/sta.2013.6783096.

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Maria, Smirnova, and Smirnov Mikhail. "Modal synthesis of astatic controllers for yaw stabization system." In 2013 XXIV International Conference on Information, Communication and Automation Technologies (ICAT). IEEE, 2013. http://dx.doi.org/10.1109/icat.2013.6684041.

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Maria, Smirnova, and Smirnov Mikhail. "Synthesis of astatic control laws of marine vessel motion." In 2013 18th International Conference on Methods & Models in Automation & Robotics (MMAR). IEEE, 2013. http://dx.doi.org/10.1109/mmar.2013.6669992.

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Kazantsev, Vladimir, Anatoly Lykov, and Dmitry Dadenkov. "The issue of invariance and astatic control in servosystems." In 2016 IX International Conference on Power Drives Systems (ICPDS). IEEE, 2016. http://dx.doi.org/10.1109/icpds.2016.7756720.

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Uusitalo, J., U. Jakobsson, and Bertram Blank. "Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line." In THE 4TH INTERNATIONAL CONFERENCE ON PROTON EMITTING NUCLEI AND RELATED TOPICS. AIP, 2011. http://dx.doi.org/10.1063/1.3664144.

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Reports on the topic "Astatide":

1

Ruth, T. J., M. Dombsky, J. M. D'Auria, and T. E. Ward. Radiochemistry of astatine. Office of Scientific and Technical Information (OSTI), January 1988. http://dx.doi.org/10.2172/6748269.

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Wilbur, Daniel. Automated Isolation of Astatine-211 and Chemistry Evaluation. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1651207.

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Mach, Robert, Hsiaoju Lee, Mehran Makvandi, Sean Reilly, Ho Sze Chan, Paul Martorano, and David Schaub. Production of Astatine-211 for Translational Science in Radiotherapy. Office of Scientific and Technical Information (OSTI), March 2024. http://dx.doi.org/10.2172/2329303.

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Wilbur, D. S. Pretargeting of Astatine-211 for Therapy of Metastic Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada374830.

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Lapi, Suzanne E. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1575920.

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Ellison, Paul, Jonathan Engle, Aeli Olson, Todd Barnhart, Robert Nickles, Sabrina Hoffman, Dhanabalan Murali, Onofre DeJesus, and Bryan Bednarz. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), January 2020. http://dx.doi.org/10.2172/1682261.

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Mach, Robert. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1839290.

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Wilbur, Daniel Scott. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators". Office of Scientific and Technical Information (OSTI), December 2012. http://dx.doi.org/10.2172/1124492.

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MICHAEL R. ZALUTSKY. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS. Office of Scientific and Technical Information (OSTI), August 2012. http://dx.doi.org/10.2172/1047758.

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Zalutsky, Michael. Production of Astatine-211 at the Duke University Medical Center for its regional distribution. Office of Scientific and Technical Information (OSTI), January 2016. http://dx.doi.org/10.2172/1233560.

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