Dissertations / Theses on the topic 'Assembly'
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Donaldson, James Ellsworth. "assembly of: architectrure: of assembly." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/34351.
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The thesis project was the vehicle for an investigation of prefabrication, assembly, and the design of a lived space. Elements are separated from the building and from each other. This separation is both physically and functionally significant. This separation of elements is presented as the architecture of a joint. The wall is divided into two parts: exterior and interior; creating a wall that is analogous to a double wall system. The exterior wall is the weather barrier, while the interior wall houses the functional necessities for a building, and the extremities of lived spaces. The gap, or joint, is exploited for its ability to be a transportation system. The joint is both vertical and horizontal, separating inside from outside and one unit from the other. The clarity of elements and the method of construction articulates the joint. A well designed element is fabricated and brought to the site. Its independence in construction is a metaphor for the element's ability to stand alone with its architecture, and when assembled underlines the strengths of the unit. The unit presented is one investigation of the varying possibilities of assembly.Master of Architecture
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Purdy, John Gerard Craven Rebecca C. "To assemble, or not to assemble the initiation of retroviral capsid assembly /." [University Park, Pa.] : Pennsylvania State University, 2009. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-4649/index.html.
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Dillenback, Lisa M. Keating Christine Dolan. "Self-assembly and controlled assembly of nanoparticles." [University Park, Pa.] : Pennsylvania State University, 2008. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-2613/index.html.
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Marehalli, Jayavardhan N. "Assembly Sequence Optimization and Assembly Path Planning." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/44837.
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This thesis addresses two important aspects of automatic assembly viz., assembly sequence planning and assembly path planning. These issues are addressed separately starting with sequence planning followed by assembly path planning.
For efficient assembly without feedback systems (or, passive assembly), an assembler should know the ideal orientation of each component and the order in which to put the parts together (or, assembly sequence). A heuristic is presented to find the optimal assembly sequence and prescribe the orientation of the components for a minimum set of grippers = ideally one. The heuristic utilizes an index of difficulty (ID) that quantifies assembly. The ID for each task in the assembly process is computed on the basis of a number of geometrical and operational properties. The objective of the optimization problem here is to minimize the assembly ID and categorize parts/subassemblies based on their preferred direction of assembly while allowing re-orientation of the base part. It is assumed that the preferred direction of assembly is vertically downward, consistent with manual as well as most automatic assembly protocols. Our attempt is to minimize the number of degrees of freedom required in a re-orienting fixture and derive the requirements for such a fixture. The assembly of a small engine is used as an example in this study due to the variety of ideally rigid parts involved.
In high precision assembly tasks, contact motion is common and often desirable. This entails a careful study of contact states of the parts being assembled. Recognition of contact states is crucial in planning and executing contact motion plans due to inevitable uncertainties. Dr. Jing Xiao of UNCC introduced the concept of principal contacts (PC) and contact formation (CF) for contact state recognition. The concept of using CFs (as sets of PCs) has the inherent advantage that a change of CF is often coincident with a discontinuity of the general contact force (force and torque). Previous work in contact motion planning has shown that contact information at the level of PCs along with the sensed location and force information is often sufficient for planning high precision assembly operations. In this thesis, we present results from experiments involving planned contact motions to validate the notion of PCs and CFs -- an abrupt change in general contact force often accompanies a change between CFs. We are only concerned with solving the 2D peg-in-corner problem.Master of Science
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Falcone, Sara Elizabeth. "Zipped assembly." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129871.
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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, February, 2020Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 70-71).
Biology creates assemblies with orders of magnitude more parts than any known human designed process. Molecular biology functions on the premise that fundamental building blocks assemble into chains, are zipped into strands and folded into structures. This thesis is a macroscale implementation that aims to do the same, assemble, zip and fold, in an inorganic system. This system, Zipped, utilizes distributed coalescence of parts, aiming for faster assembly while incorporating error correction into the fabrication process. This thesis presents a design for 0-dimensional building blocks that snap together to form 1-dimensional strands. Strands zip together, interlocking to form 2-dimensional beams that can branch and merge to create patterns or flat sheets. Strands can zip to each other out of plane as well, allowing 3-dimensional construction.
All steps of the construction process are reversible; parts can be assembled, dis-assembled and re-assembled without damage to the part or altering structural performance. No energy, formwork or pre-load is required to maintain the parts position once it is assembled. The system can assemble rigid as well as flexural elements, including chains and revolute joints. Increased stiffness or flexibility can be designed into structures by changing strand geometry and zipping. This ability to tune local structural properties allows actuators to be added to the construction system and form mechanisms. Zipped pieces are demonstrated as the structural element for a robot's body, which can locomote on itself or foreign terrain. Initial studies also demonstrate automated construction with this system. The fundamental principles of this system are demonstrated in many materials, via different manufacturing processes and across several scales, showing applicability to a diverse scenario space.
For ease of fabrication and lab use a centimeter scale part was selected and several thousand parts were manufactured. This 0-dimensional part is presented and used to form larger scale assemblies which are mechanically characterized. From here, mission architectures and real-world applications are described. The Zipped system enables human-scale, controlled and reversible assembly, zipping and folding. This allows reusability, reconfigurability and universality - attributes we often credit to nature.
by Sara Falcone.
S.M.
S.M. Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences
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Titenko, A. І. "Assembly language." Thesis, Сумський державний університет, 2012. http://essuir.sumdu.edu.ua/handle/123456789/28614.
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Heslyk, Oskar. "Visual Assembly." Thesis, KTH, Arkitektur, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298507.
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The project investigates an aesthetic of assembly. It established a visual expression though exploring the relationship between disassembly and assembly in the context of laminated timbers. These explorations are manifested in a learning institution in relationship to an existing CLT factor in Långshyttan. The project becomes a dynamic celebration of assembly and a continuous learning environment as the building continues to disassemble and reassemble to counter the obsolescent of new technological inventions in a rapidly developing industry driven by industrialization and technological determination. The new building feeds of the factory for purely disassembled parts in terms of discarded waste and a pure form of assembly in terms of unprocessed CLT blanks. The production of industrial produced mass timber elements has further moved the production of buildings into factories and the erection of buildings at site consist primarily of an assembly of predesigned parts. Architectural advancements is inseparable from technological paradigms and the production of construction timber should carry with it new architectural expressions.
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Kim, Joan. "Assembly furniture." Thesis, University of Iowa, 2019. https://ir.uiowa.edu/etd/6781.
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Ustun, Cevat. "Improving genome assembly." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2957.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.Thesis research directed by: Physics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Fox, Michael Jacob. "Stochastic self-assembly." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34741.
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We present methods for distributed self-assembly that utilize simple rule-of-thumb control and communication schemes providing probabilistic performance guarantees. These methods represents a staunch departure from existing approaches that require more sophisticated control and communication, but provide deterministic guarantees. In particular, we show that even under severe communication restrictions, any assembly described by an acyclic weighted graph can be assembled with a rule set that is linear in the number of nodes contained in the desired assembly graph. We introduce the concept of stochastic
stability to the self-assembly problem and show that stochastic stability of desirable configurations can be exploited to provide probabilistic performance guarantees for the process. Relaxation of the communication restrictions allows simple approaches giving deterministic guarantees. We establish a clear relationship between availability of communication and convergence properties. We consider Self-assembly tasks for the cases of many and few
agents as well as large and small assembly goals. We analyze sensitivity of the presented process to communication errors as well as ill-intentioned agents. We discuss convergence rates of the presented process and directions for improving them.
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Rekiek, Brahim. "Assembly line design." Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211676.
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CHANG, MING, and MOHAMAD TALIB. "Design for assembly." Thesis, KTH, Tillämpad maskinteknik (KTH Södertälje), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-138008.
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Ng, Yau-man Ivan, and 吳優文. "HKSAR legislative assembly." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31982165.
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Mairopoulos, Dimitrios. "M-Cell assembly." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99294.
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Thesis: S.M., Massachusetts Institute of Technology, Department of Architecture, June 2015.Cataloged from PDF version of thesis. "June 2015."
Includes bibliographical references (page 47).
In this thesis I propose a self- assembly procedure called the Morphocell(M-Cell) assembly. This procedure is based on an assembly unit called the M-Cell. The M-Cell is comprised out of two components, the M-Block and the M-Clay (in which the M-Block is embedded). During the assembly procedure the M-Clay acts as the environment of the assembly for the M-Blocks. This allows a global, parallel assembly that is highly autonomous and has large error correcting capacities. When the assembly procedure is complete the M-Blocks have assembled into a spatial lattice. Then the M-Clay surrounds this lattice thus creating a solid object, the M-Object. The M-Object, which is the goal of this procedure, is a dynamic object that can be easily modified, expanded or dismantled. Furthermore, it can respond in various ways to its environment. This system was optimized though a feedback loop that was informed by constant digital and physical simulations. The findings of this thesis can have important applications in construction of structures in extreme-remote environments and in the fabrication-rapid prototyping field.
by Dimitrios Mairopoulos.
S.M.
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Waring, Thomas George. "Integrated silicon assembly." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/13210.
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The problem of silicon assembly contains several well-separated steps that can be identified. To solve the assembly problem, use can be made of the stepwise approach to assembly, which involves finding ways of performing the individual steps and then linking the steps together to realise a silicon assembler. However, experience has shown that this approach produces poor-quality results, not because of the failure of the individual steps, but rather because of the breakdown in communication between the steps. Silicon assembly is a programming problem whose results are significantly affected by how the problem is decomposed into sub-problems. Building on the experience gained from implementing a stepwise assembler a novel integrated approach to solving the assembly problem is presented, which overcomes the communication problems inherent in the stepwise approach. Experimental results obtained using an integrated assembler are comparable to or better than those produced by existing assemblers. The integrated approach is simple in concept and easy to implement, yet produces good results, and is a suitable platform for taking silicon assembly forward in the 1990's.
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Dunn, Katherine Elizabeth. "DNA origami assembly." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:dff1bafd-e355-4df5-968b-b0deb7e6f44f.
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This thesis describes my investigations into the principles underlying self-assembly of DNA origami nanostructures and discusses how these principles may be applied. To study the origami folding process I designed, synthesized and characterized a polymorphic tile, which could adopt various shapes. The distribution of tile shapes provided new insights into assembly. The origami tiles I studied were based on scaffolds derived from customized plasmids, which I prepared using recombinant DNA technology. I developed a technique to monitor incorporation of individual staples in real time using fluorescence, measuring small differences in staple binding temperatures (~0.5-5 °C). I examined the tiles using Atomic Force Microscopy and I found that a remarkably high proportion of polymorphic tiles folded well, which suggests that there are assembly pathways, arising from strong cooperation between staples. In order to analyse the tile shapes quantitatively, I developed a specialized image processing technique. For validation of the method, I generated and analysed simulated data, and the results confirmed that I could measure individual tile parameters with sub-pixel resolution. I studied eleven variants of the polymorphic tile, and I proved that minor staple modifications can be used to change the folding pathway dramatically. The strength of cooperation between staples affects their behaviour, which is also influenced by their length and base sequences. Paired staples are particularly significant in assembly, and there are clear parallels with protein folding. I describe in an Appendix how I applied origami assembly principles in the development of my concept for an autonomous rotary nanomotor utilizing the sequential opening of DNA hairpins (already used for linear motors). This device represents an advance over non-autonomous rotary motors and I have simulated its performance. In this thesis I have answered important questions about DNA origami assembly, and my findings could enable the development of more sophisticated DNA nanostructures for specific purposes.
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Spanton, Robert. "Stateful self-assembly." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/355888/.
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Nature shows us many organised structures that form through interactions between their components with little external guidance. These self-assembling systems range from simple crystals to considerably more complex biological structures and organisms. Inspired by these systems, the development of programmable self assembling systems could lead to mass manufacturing processes that produce individually unique items. Current artificial self-assembling systems involve small numbers of centimetre-scale components, and have not resulted in structures anywhere near the complexity seen in natural systems. This thesis argues that to advance artificial self-assembling systems towards this complexity, the statistics of the interactions within self-assembling systems need to be empirically examined and understood. However, the pursuit of this involves the resolution of a variety of technical challenges. These are approached in this work through the development of a self-assembly toolkit that allows the collection of these statistics from a physical system with larger numbers of components than in previous works. A novel capacitive communication interface is developed for the components of this toolkit, which allows messaging between neighbouring components that are constrained to the surface of a plane. As self-assembling components reduce in size towards the microscale, the penalty for incorrect activation of a component’s binding mechanism is likely to increase. With this in mind, this capacitive communication interface is optimised to provide spatial alignment sensing, with the aim of allowing informed binding mechanism activation. The toolkit developed in this work uses components that are constrained to two degrees of freedom of motion. In pursuit of the development of programmable self-assembling components for 3D structures, a new design of alignment sensor for use in 3D is created. Simulation of this sensor, which is developed using an evolutionary algorithm, indicates that it is suited for detecting the alignment of components with three degrees of freedom. Approaches using computer vision are developed for the spatial tracking of the components of the toolkit, allowing the collection of empirical data regarding the interaction of components. The technical advances described within this work will allow the progression of data-driven self-assembly process design.
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Lackmann, Fredrik. "Nucleolar Ribosome Assembly." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-145639.
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Ribosomes are macromolecular machines that are responsible for production of every protein in a living cell. Yet we do not know the details about how these machines are formed. The ribosome consists of four RNA strands and roughly 80 proteins that associate with each other in the nucleolus and form pre-ribosomal complexes. Eukaryotes, in contrast to prokaryotes, need more than 200 non-ribosomal factors to assemble ribosomes. These associate with pre-ribosomal complexes at different stages as they travel from the nucleolus to the cytoplasm and are required for pre-rRNA processing. We do however lack knowledge about the molecular function of most of these factors and what enables pre-rRNA processing. Especially, information is missing about how non-ribosomal factors influence folding of the pre-rRNA and to what extent the pre-ribosomal complexes are restructured during their maturation. This thesis aims to obtain a better understanding of the earliest events of ribosome assembly, namely those that take place in the nucleolus. This has been achieved by studying the essential protein Mrd1 by mutational analysis in the yeast Saccharomyces cerevisiae as well as by obtaining structural information of nucleolar pre-ribosomal complexes. Mrd1 has a modular structure consisting of multiple RNA binding domains (RBDs) that we find is conserved throughout eukarya. We show that an evolutionary conserved linker region of Mrd1 is crucial for function of the protein and likely forms an essential module together with adjacent RBDs. By obtaining structural information of pre-ribosomal complexes at different stages, we elucidate what structuring events occur in the nucleolus. We uncover a direct role of Mrd1 in structuring the pre-rRNA in early pre-ribosomal complexes, which provides an explanation for why pre-rRNA cannot be processed in Mrd1 mutants.At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Manuscript. Paper 4: Manuscript.
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Chen, Ho-Lin. "Robust self-assembly /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
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Ng, Yau-man Ivan. "HKSAR legislative assembly." Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25945233.
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Cline, John Michael. "A Solemn Assembly." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1012.
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A group of oil paintings completed in partial requirement of my MFA degree is discussed. The paintings are on wood panels and are the result of a combination of old master techniques of under-painting and glazing and more contemporary approaches to the painting process. Each painting represents a particular concept or event from Mormon theology; whereas, the pictorial structure is inspired by Medieval manuscript painting. Thus, this body of work is a synthesis between two worldviews existing centuries apart, yet sharing certain core values and beliefs.
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Engel, Stephanie Vanessa. "Assembly von Influenzaviren." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15918.
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Es wird angenommen, dass das Influenzavirus-Glykoprotein Hämagglutinin (HA) für seine Funktion sowohl bei der Virusfreisetzung als auch bei der Fusion von viraler und zellulärer Membran mit Cholesterin- und Sphingolipidreichen Domänen, sogenannten Membran-Rafts, assoziiert sein muss. Aus diesem Grund sollte in dieser Arbeit die Membran-Raft-Affinität von HA in lebenden Zellen mittels FLIM-FRET gemessen werden. Dabei wurde mit Hilfe der Fluroreszenz-Lebenszeit-Messung (FLIM) der Förster-Resonanz-Energie-Transfer (FRET) von fluoreszenzmarkiertem HA auf einen etablierten Raft-Marker bestimmt. Diese Messungen zeigten, dass beide Proteine in gemeinsamen Klustern in der Plasmamembran vorkommen. Durch Cholesterinentzug und durch den Einsatz von Cytochalasin D, welches die Mikrofilamente zerstört, konnte diese Klusterbildung reduziert werden. Demnach tragen sowohl die Membran-Rafts als auch das Aktinnetzwerk zu dieser Klusterbildung bei. Mittels FLIM-FRET konnte zusätzlich bestätigt werden, dass die Signale für die Detergenslöslichkeit von HA in Triton-Extraktionsexperimenten, die Palmitylierung und die stark hydrophoben Aminosäuren zu Beginn der Transmembrandomäne (TMD), auch im lebenden System eine wichtige Rolle spielen. Zusätzlich konnten biochemische Experimente zeigen, dass die hydrophoben Aminosäuren zu Beginn der HA-TMD den intrazellulären Transport, nach der Trimerbildung, entscheidend verzögern. Diese Verzögerung ist vermutlich auf einer erschwerten Integration dieser Proteine in die Membran-Rafts begründet. Die virale Fusion mit der Wirtszellmembran wird durch eine pH5-Behandlung vermittelte Konformationsänderung von HA ausgelöst. FLIM-FRET-Messungen zeigten für die pH5-Konformation von HA eine verglichen mit der pH7-Konformation verringerte Klusterbildung mit dem Raft-Marker. Somit ist offensichtlich, dass die Membranfusion-vermittelnde HA-Konformation eine verringerte Raft-Affinität besitzt. Diese verringerte Raft-Affinität könnte eine wichtige Rolle bei der Störung der Lipide an der Fusionsstelle spielen und somit die Bildung und/oder Vergrößerung der Fusionspore erleichtern.It has been supposed that the hemagglutinin (HA) of influenza virus is recruited to cholesterol- and sphingolipid-enriched domains, also named membrane-rafts, to accomplish its function in virus budding and membrane fusion. This study aimed at verifying the affinity of HA for membrane-rafts in living cells using fluorescence-lifetime imaging microscopy to measure Förster’s resonance energy transfer (FLIM-FRET). FLIM-FRET revealed strong clustering between a fluorescence-tagged HA-protein and a well-established raft-marker in CHO cells. Clustering was significantly reduced when rafts were disintegrated by cholesterol depletion and when microfilaments were disrupted with cytochalasin D. Thus, membrane-rafts as well as the actin meshwork contribute synergistically to clustering. Clustering was also reduced by the removal of the known signals for the association of HA with detergent-resistant-membranes, the palmitoylation and the first amino acids in the transmembrane region (TMR). Since these mutations are obviously important for the raft-association of HA their function during the transport through the ER and the Golgi-complex was studied. These investigations showed that the exchange of the first three amino acids of the HA-TMR led to a decelerated transport after trimer-formation of the protein, probably due to retarded integration of these proteins into membrane-raft domains. Mediating viral fusion with the host cell membrane requires an irreversible conformational change of HA. FLIM-FRET studies of this low pH conformation unveiled that the clustering with the raft-marker is decisively reduced compared to the pre-fusion conformation of the protein. It might be assumed that the fusion-mediating conformation of HA reduces the proteins affinity for membrane-rafts. Therefore it is likely that this reduced affinity for rafts after the conformational change is relevant to cause perturbation of lipids at the fusion site and thereby facilitating the formation and/or enlargement of the fusion pore.
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Höfer, Chris Tina. "Influenza virus assembly." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17251.
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Influenza A Viren besitzen ein segmentiertes, einzelsträngiges RNA-Genom, welches in Form viraler Ribonukleoprotein (vRNP)-Komplexe verpackt ist. Während das virale Genom im Zellkern repliziert wird, finden Assemblierung und Knospung reifer Viruspartikel an der apikalen Plasmamembran statt. Für die Virusbildung müssen die einzelnen viralen Komponenten hierher gebracht werden. Während intrinsische apikale Signale der viralen Transmembranproteine bekannt sind, sind der zielgerichtete Transport und der Einbau des viralen Genoms in neuentstehende Virionen noch wenig verstanden. In dieser Arbeit wurden potentielle Mechanismen des vRNP-Transportes untersucht, wie die Fähigkeit der vRNPs mit Lipidmembranen zu assoziieren und die intrinsische subzellulären Lokalisation des viralen Nukleoproteins (NP), eines Hauptbestandteils der vRNPs. Es konnte gezeigt werden, dass vRNPs nicht mit Lipidmembranen assoziieren, was mittels Flotation aufgereinigter vRNPs mit Liposomen unterschiedlicher Zusammensetzung untersucht wurde. Die Ergebnisse deuten jedoch darauf hin, dass das virale M1 in der Lage ist, Bindung von vRNPs an negativ-geladene Lipidmembranen zu vermitteln. Subzelluläre Lokalisation von NP wurde des Weiteren durch Expression fluoreszierender NP-Fusionsproteine und Fluoreszenzphotoaktivierung untersucht. Es konnte gezeigt werden, dass NP allein nicht mit zytoplasmatischen Strukturen assoziiert, stattdessen aber umfangreiche Interaktionen im Zellkern eingeht und mit hoher Affinität mit bestimmten Kerndomänen assoziiert, und zwar den Nukleoli sowie kleinen Kerndomänen, welche häufig in der Nähe von Cajal-Körperchen und PML-Körperchen zu finden waren. Schließlich wurde ein experimenteller Ansatz etabliert, welcher erlaubt, den Transport vRNP-ähnlicher Komplexe mittels Fluoreszenzdetektion aufzuzeichnen und Einzelpartikelverfolgungsanalysen durchzuführen. Unterschiedliche Phasen des vRNP-Transportes konnten beobachtet werden und ein 3-Phasen-Transportmodell wird skizziert.Influenza A viruses have a segmented single-stranded RNA genome, which is packed in form of viral ribonucleoprotein (vRNP) complexes. While the viral genome is replicated and transcribed in the host cell nucleus, assembly and budding of mature virus particles take place at the apical plasma membrane. Efficient virus formation requires delivery of all viral components to this site. While intrinsic apical targeting signals of the viral transmembrane proteins have been identified, it still remains poorly understood how the viral genome is transported and targeted into progeny virus particles. In this study, potential targeting mechanisms were investigated like the ability of vRNPs to associate with lipid membranes and the intrinsic ability of the viral nucleoprotein (NP) – which is the major protein component of vRNPs – for subcellular targeting. It could be shown that vRNPs are not able to associate with model membranes in vitro, which was demonstrated by flotation of purified vRNPs with liposomes of different lipid compositions. Results indicated, however, that the matrix protein M1 can mediate binding of vRNPs to negatively charged lipid bilayers. Intrinsic subcellular targeting of NP was further investigated by expression of fluorescent NP fusion protein and fluorescence photoactivation, revealing that NP by itself does not target cytoplasmic structures. It was found to interact extensively with the nuclear compartment instead and to target specific nuclear domains with high affinity, in particular nucleoli and small interchromatin domains that frequently localized in close proximity to Cajal bodies and PML bodies. An experimental approach was finally established that allowed monitoring the transport of vRNP-like complexes in living infected cells by fluorescence detection. It was possible to perform single particle tracking and to describe different stages of vRNP transport between the nucleus and the plasma membrane. A model of three-stage transport is suggested.
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Windhof, Amanda. "Rubisco folding and oligomeric assembly: Detailed analysis of an assembly intermediate." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-136192.
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Agarwal, Gunjan. "Selective assembly in deformable systems using templated assembly by selective removal." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/50571.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Includes bibliographical references (p. 140-143).
The current work presents the first demonstration of successful assembly of deformable polymer microspheres on patterned rigid substrates using Templated Assembly by Selective Removal (TASR). Also presented is a quantitative model for predicting the successful self-assembly of deformable materials using TASR. Successful assembly of silica microspheres using TASR on a silicon template carried out in previous work has established that the technique works effectively for assembly of hard materials on a rigid substrate. However, the situation for the assembly of soft materials is different. In systems comprising soft materials, the contact area between the two mating surfaces can potentially change via deformation which influences the shape matching between the component and the substrate that TASR relies on as its underlying principle. The contact area at the interface is in turn decided by the nature of contact between the two interacting surfaces. Therefore, the Hertzian elastic theory for contact between a sphere was used for deciding whether the assembly of two new materials is attributed to shape matching or to plastic deformation. In accordance with the stated hypothesis, it was concluded that the assembly of Polystyrene (PS) microspheres on a rigid substrate such as silicon will yield successful results. Experiments were conducted to confirm this deduction from theoretical analysis.
(cont.) The thesis presents simultaneous self assembly of 2 [mu]m diameter polystyrene microspheres on a patterned silicon template, where grids with uniformly well-matched hole sizes were completely filled demonstrating nearly 100% assembly yield while grids with varying hole sizes demonstrate selectivity in assembly. Quantitative comparison of the data on assembly of deformable systems with existing TASR models for non-deformable systems shows significant agreement. The predictive model for self assembly of deformable materials can pave the way for assessing the viability of trying out the assembly of a new material by comparing its parametric values with those that have already been successfully demonstrated and established.
by Gunjan Agarwal.
S.M.
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Johnson, Joshua A. Dr. "Control of DNA Origami from Self-Assembly to Higher-Order Assembly." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1577996668813983.
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Mòdol, Cano Aitor 1993. "Role of RanGTP and spindle assembly factors in cilia assembly and function." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671696.
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El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor. La importancia del cilio es patente por las ciliopatías como la enfermedad renal policística y los defectos en el desarrollo embrionario causadas por sus defectos de funcionamiento. Sin embargo, el mecanismo que regula el ensamblaje y desensamblaje de esta estructura y su dinámica no han sido totalmente esclarecidas aún. Datos previos sugieren que RanGTP, un regulador esencial del ensamblaje y organización de microtúbulos durante la mitosis, localiza en el cilio. En este trabajo hemos estudiado el posible papel de RanGTP en el ensamblaje y función del cilio. Observamos que RanGTP y otros componentes de la maquinaria del transporte nucleo-citoplasmático localiza en el cilio. Además, identificamos RPGR como un posible candidato RanGEF en el cilio. Además, identificamos varios factores de ensamblaje del huso mitótico regulados por RanGTP (SAFs) que localizan también en el cilio. Finalmente, hemos caracterizado uno de ellos, DnaJB6. Esta proteína es necesaria para el correcto ensamblaje del cilio a través de un mecanismo que podría involucrar al complejo motor dineina-dinactina.
En conclusión, nuestros datos indican que RanGTP y algunos de sus efectores tienen un papel fundamental en el ensamblaje y función del cilio.
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Haskiya, Wasim. "Robotic assembly : chamferless peg-hole assembly operation from X/Y/Z directions." Thesis, De Montfort University, 2000. http://hdl.handle.net/2086/4816.
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Lundström, Jonathan, and Emil Hörnberg. "Rotator assembly at Indexator." Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-64058.
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The thesis is concerning rotator assembly at Indexator. A need to increase production has been seen and it can be done by implementing an optimized assembly process. In addition to the assembly process a new design on workstations and new test equipment is needed.The study resulted into three assembly process proposals. The processes were balanced, layouts were produced and Plant simulation was utilized to produce simulation models. Each proposal were analyzed based on cost, performance, ease of implementation, flexibility and worker condition. This resulted in a stationary assembly process being most promising and a 3D simulation model was produced for visualization and better understanding. The stationary assembly process has a capacity for 90 rotators per day, while reducing the amount of workers by one.The layout of the workstations was done based on the assembly process layout and further developed to make the work cell lean and ergonomic. It resulted in three workstations to perform the assembly. The test bench was developed by creating target specifications, establish a test procedure and decide components for the test bench layout. The finished test bench can measure dynamic torque, count particles to ensure cleanliness and is able to run the test unattended.Examensarbetet handlar om montering av rotatorer på Indexator. Målet är att ta fram en optimerad monteringsprocess som kan implementeras i Indexators fabrik utan svårigheter. Den nya monteringsprocessen kommer kräva en ny design på arbetsstationerna och nya testbänkar.Fyra koncept på monteringsprocessen togs fram, baserat på monteringens behov och målsättning. Efter utvärdering så modifierades de fyra koncepten till tre förslag på monteringsprocesser. Processerna balancerades, layouter utvecklades och simuleringsmodeller producerades för varje process. Varje förslag analyserades baserat på kostnad, prestanda, implementation,flexibilitet och arbetar-förhållande. Resultatet blev en stationär monteringsprocess och en 3Dsimulering gjordes för visualisering och förståelse. Den stationära monteringsprocessen har en kapacitet på 90 rotatorer per dag och reducerar behovet av montörer.Layouten för monteringsstationerna baseras på processens layout och har modifierats för ergonomiska aspekter. Inom monteringsstationerna så utvecklades layouten för att minimera antalet onödiga rörelser för montören. Testriggens design utvecklades genom att analysera de behov som fanns, skapa en kravspecifikation samt utvärdera och besluta om testprocedur, upplägg för testrigg och dess ingående komponenter. Testriggen uppfyller målsättningen som är att kunna mäta dynamiskt vridmoment, räkna partiklar för att säkerställa renhet i rotatorn och kunna utföra testningen självgående för att frigöra montören under testprogrammet.
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Eskilander, Stephan. "Design for automatic assembly." Doctoral thesis, KTH, Production Engineering, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3128.
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Seran, Onur. "Visually Guided Robotic Assembly." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/4/1223353/index.pdf.
Full textAbstract:
This thesis deals with the design and implementation of a visually
guided robotic assembly system. Stereo imaging, three dimensional location
extraction and object recognition will be the features of this system. This
thesis study considers a system utilizing an eye-in-hand configuration. The
system involves a stereo rig mounted on the end effector of a six-DOF ABB
IRB-2000 industrial robot. The robot is controlled by a vision system, which
uses open-loop control principles. The goal of the system is to assemble
basic geometric primitives into their respective templates.
Recognition
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Scholand, Andrew Joseph. "Analysis-enhanced electronic assembly." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/18900.
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McLachlan, Donald Stuart. "Flexible assembly cell manipulator." Thesis, University of Hull, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296278.
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Williams, Richard James. "Enzyme assisted self-assembly." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496231.
Full textAbstract:
Self-assembling peptide systems provide a pathway for the formation of complex molecular assemblies from relatively simple designed molecules. Stimuli which have been used to trigger the self-assembly (SA) process in aqueous conditions include temperature, pH, ionic strength, and solvent exchange. Additionally, enzymes may be used to selectively control the self-assembly process; enzymes are uniquely chemo-, regio-, and enantioselective, and work naturally under mild conditions without disrupting biological Interactions.
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Manser, E. J. "Aspects of microtubule assembly." Thesis, Open University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484401.
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Moffat, Jonathan. "Assembly of biopolymer multilayers." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435024.
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Thomas, Joanne Marie. "Assembly of influenza viruses." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326757.
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Carney, Matthew Eli. "Discrete cellular lattice assembly." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101845.
Full textAbstract:
Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 109-113).
Robotic assembly of discrete cellular lattices at super-hertz (>1Hz) assembly rates is shown to be possible by integrating the design of a modular robotic assembler with the specified lattice topology such that the lattice can itself be removed from the incremental assembly process. Limits to assembly rates are ultimately dependent on allowable error, system stiffness, and damping characteristics. Vibrations due to cyclical motions of the end-effector, locomotion system, and the dynamic response of an incrementally varying lattice must settle to acceptable ranges to enable engagement between end-effectors, discrete elements, and their affixing features to adjacent cells. For given system dynamics, longer settling times enables greater energy dissipation, and less error. With a greater allowable error at the interface, a shorter assembly cycle period can be attained. Passive alignment features designed into the robot end-effectors, locomotion systems, and the discrete lattice elements reduce the precision requirements of the assembly process by opening up the acceptable error range, thereby, enabling higher assembly cycle-rates. An experiment was performed to evaluate how an assembler locally referencing a lattice performed in comparison to a globally referenced assembler. The two assemblers were of similar kinematic form: both gantry-type CNC machines: a ShopBot and a custom built relative robotic assembler. The results showed superior performance by the global coordinate frame system. An error budget analysis of the two systems showed that the locally referenced, lattice based system had a larger more variable structural loop than the global coordinate frame ShopBot. The control experiment, demonstrated 0.1Hz assembly rates, while first order approximations predict a maximum 4Hz cycle for the specified interface geometry. Results show that in order to successfully assemble discrete cellular lattices at super-hertz rates the robot must itself become the local, instantaneous global coordinate frame such that the structural loop is absolutely minimized, while stiffness is maximized; at the instantaneous moment of assembly the structural loop of the robot must reference only itself.
by Matthew Eli Carney.
S.M.
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Cheng, Diana I. "Magnetic assisted statistical assembly." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45999.
Full textAbstract:
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.Includes bibliographical references (p. 87).
The objective of this thesis is to develop a process using magnetic forces to assemble micro-components into recesses on silicon based integrated circuits. Patterned SmCo magnetic thin films at the bottom of recesses are used to provide forces to orient, align and retain micro-devices on silicon. The overall objective is to obtain functionalities not readily available from silicon device structures alone. This thesis was done in the context of assembling optoelectronic devices, specifically integrating vertical cavity surface emitting lasers (VCSELs), edge-emitting lasers (EELs), and light emitting diodes(LEDs) onto commercially processed Si-CMOS circuits. This method, magnetically assisted statistical assembly (MASA), incorporates past methods such as Fluidic Assisted Self- Assembly (FASA) and Recess Mounting with Monolithic Metalization (RM3). Specifically, MASA addresses the main limitation to the FASA method by adding a magnetic layer as a restraint to keep assembled components correctly positioned in recesses until the time bonding may occur. Thus, all components may be permanently bonded into place simultaneously saving both time and money. This thesis will present simulations using Ansoft's Maxwell 3d providing general behavioral intuition for the behavior of a device over a target magnetic substrate. These results include using a rectangle instead of a circular disc and making recess depths greater than 2pm to overcome gravitational forces when inverting the substrate. Patterns of SmCo magnetic material, based on results from the simulations, included 50x100[mu]m recesses containing either a solid rectangle, thirty 5x10[mu]m rectangular pads, eighteen 5x10m rectangular pads or four 5x10m rectangular pads.
(cont.) Patterns of SmCo material also were experimented with using 50x50 [mu]m square recesses containing either a solid square or nine 5x5[mu]m square pads. Experiments with various rectangular patterns showed evidence that upside down devices do not retain as well as right side up devices. It was also seen that four 5xl0[mu]m rectangular pads did not have enough magnetic material to retain even right side up devices. Solid rectangular patterns were also determined to have too much magnetic material to align and orient the device without recesses. Once recesses were added to the experiments, the pattern with thirty 5x10m rectangles proved to assemble the most devices with an assembly ratio of 90%. However problems occurred with fabricating perfect device shapes and thus mis-shapened devices were counted in the assembly ratio. Results from experimenting with square patterns with recesses show a 88% assembly ratio with a solid square pattern. This may be due to the symmetry of the square devices and therefore has higher probability of assembly than that of the rectangular devices.
by Diana I. Cheng.
M.Eng.
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Mattsson, Jonas, and Dennis Brinkeback. "Quick Base Assembly : Konceptstudie." Thesis, Jönköping University, JTH, Industriell produktutveckling, produktion och design, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53915.
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Bo, Yingjian. "Methods in organosilane assembly." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213502.
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ChemistryPh.D.
Dialkylsilanediols are a novel class of non-hydrolyzable analogues of the tetrahedral intermediate of amide hydrolysis, shown to be good inhibitors of HIV-1 protease, angiotensin converting enzyme (ACE), and thermolysin. An impediment to utilization of these silanediol structures, however, has been the methods for their assembly. This research describes the reductive lithiation of hydridosilanes and alkoxysilanes, and the use of the resulting silyl anions to develop efficient methods to synthesize silanediol precursors. In the first part of research, lithiation of hydridosilanes was studied. As part of this study, a simple 1H NMR method was developed for monitoring and analyzing the progress of lithiation. In addition, this method was converted to a titration for silyllithium reagents using BHT as an internal standard. Silanediols 107 and 177 are analogues of a potent chymase inhibitor, NK-3201 (82). In the second part, diphenylsilanes 108 and 170, precursors to silanediols 107 and 177, were synthesized using addition of silyllithium to sulfinimine 113 as a key step. In the third part, lithiation of alkoxysilanes was studied. (Si,O)-Dianions, generated from lithiation of silane alcohol 175 or 2,2-diphenyl-1-oxa-2-silacyclopentane (225), were reacted with a wide variety of electrophiles to give potentially useful silicon-containing building blocks. Addition of the (Si,O)-dianion 284 to sulfinimines gave silanediol inhibitor precursors with full control of stereochemistry. In the last part, a new method featuring 1,1-diphenyl-2-azaallyllithium chemistry were utilized to synthesize a series of protected α-amino silanes 323, 329 - 331.
Temple University--Theses
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Maeda, Chihiro. "Chemistry of Porphyrin Assembly." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120686.
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Vallance, Robert Ryan. "Precision connector assembly automation." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/38433.
Full textAbstract:
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1999.Includes bibliographical references (p. 209-214).
Telecommunication systems, network servers, mainframes, and high-performance computers contain several printed circuit boards (PCBs) that are mounted in card-cage assemblies. Level-3 connectors, often called board-to-board connectors, transmit signals between the primary backplane PCB and the daughter card PCBs. These connectors are customized for each PCB by configuring modules along the length of the connector. Hence, the connector's assembly system must flexibly accommodate the connector configurations. Prior to this research, the assembly of daughter card connectors was a manual process. This thesis presents the conceptual design of an assembly cell, and thoroughly presents the selected concept, a flexible assembly system. In the flexible assembly system, the connector is fixtured on a pallet and transferred to assembly stations on a conveyor. The pallet must be precisely located at each station, to minimize the relative errors between the new component and the connector on the pallet. Kinematic couplings deterministically locate one rigid body with respect to another. Therefore, a pallet system was developed that uses split-groove kinematic couplings between the pallets and machines. Experiments demonstrated that the split-groove kinematic pallet was approximately O1X more repeatable than conventional pallet location methods. The design is evident in the fabrication and operation of the first automated machines for the connector assembly system. In automated machinery, kinematically coupled bodies are often subjected to ranges of disturbance forces. This thesis presents new methods for analyzing the static equilibrium, errors due to contact deformation, and contact stresses that result from disturbance forces. In addition, the manufacturing errors within individual pallets and machines combine to cause system-wide, variability in pallet location. Two methods are presented for estimating the system-wide variability in the position and orientation of the pallets.
by Robert Ryan Vallance.
Ph.D.
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Ye, Weihua. "Women in the Assembly : representations of female Assembly Members in the Welsh press." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/71787/.
Full textAbstract:
This study highlights the significance of equal participation of men and women as central to the future health of politics and the democratic process in Wales. Following affirmative action taken by two major Welsh political parties, the National Assembly for Wales has been notable for the high level of female representation among its membership since the legislature was created in 1999. The large number of women in the Assembly is a unique phenomenon both politically and geographically. However, the question that remains unanswered is this: in spite of equal political representation in the Assembly, are men and women now treated equally and fairly by the Welsh press? This research is the first comparative study of press representations of men and women in a political institution that has an almost equal number of male and female representatives. It specifically attempts to examine how 12 Welsh newspapers portrayed female Assembly Members [AMs] during a three-month Welsh national election period as well as during a later three-month routine press coverage period. It draws on content and discourse analyses of the press coverage of over 3000 articles from about 1000 newspaper editions during the two periods studied. It is also based on data generated by in-depth interviews with 28 AMs from the current Assembly. This study shows that when there has been a relative equal participation of women in a political institution over a period, the gender issue initially remains noticeable and “business as usual”. However, over time, more complex media representations of male and female politicians have been observed and gender bias has gradually become less salient and controversial than before, both in colleagues’ perceptions of women politicians and in media representations, because gender parity has become a norm.
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Zhang, Yuan. "MST Based Ab Initio Assembler of Expressed Sequence Tags." Miami University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=miami1273245641.
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Shanmugam, Sivamoorthy. "Automatic Sub-assembly detection, disassembly sequencing and disassembly direction prediction for an assembly model." Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1109252927.
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Probst, Martin. "Design of an advanced micro-assembly system for the assembly of bio-micro-robots /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18137.
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Rasala, Beth A. "Defining the early steps in nuclear pore assembly chromatin-associated ELYS initiates pore assembly /." Diss., View abstract only; access to full text of dissertation for UC IP will be available after 1/1/2011, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3296834.
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Thesis (Ph. D.)--University of California, San Diego, 2008.Title from first page of PDF file (viewed June 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Bihi, Thabo George. "Assembly-setup verification and quality control using machine vision within a reconfigurable assembly system." Thesis, [Bloemfontein?] : Central University of Technology, Free State, 2014. http://hdl.handle.net/11462/188.
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Thesis (M. Tech. (Engineering: Electrical)) -- Central University of technology, Free State, [2014]The project is aimed at exploring the application of Machine Vision in a Reconfigurable Manufacturing System (RMS) Environment. The Machine Vision System interfaces with the RMS to verify the reconfiguration and positioning of devices within the assembly system, and inspects the product for defects that infringe on the quality of that product. The vision system interfaces to the Multi-agent System (MAS), which is in charge of scheduling and allocating resources of the RMS, in order to communicate and exchange data regarding the quality of the product. The vision system is comprised of a Compact Vision System (CVS) device with fire-wire cameras to aid in the image acquisition, inspection and verification process. Various hardware and software manufacturers offer a platform to implement this with a multiple array of vision equipment and software packages. The most appropriate devices and software platform were identified for the implementation of the project. An investigation into illumination was also undertaken in order to determine whether external lighting sources would be required at the point of inspection. Integration into the assembly system involved the establishment communication between the vision system and assembly system controller.
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Bhoja, Sudeer. "Optimization of the Assignment of Printed Circuit Cards to Assembly Lines in Electronics Assembly." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/37006.
Full textAbstract:
The focus of this research is the line assignment problem in printed circuit card assembly systems. The line assignment problem involves the allocation of circuit card types to an appropriate assembly line among a set of assembly lines with the objective of reducing the total assembly time. These circuit cards are to be assembled in a manufacturing facility, capable of simultaneously producing a wide variety of printed circuit cards in different production volumes. A set of component types is required for each printed circuit card. The objective is to assign the circuit cards to the assembly line such that the total assembly time, which includes the setup time as well as the processing time required for all card types in a set, is minimized.
The focus of this research is to develop an algorithmic strategy for addressing this problem in electronics assembly. This problem involves considering several interrelated decision problems such as assigning printed circuit cards to assembly lines, grouping circuit cards into families to reduce the number of setups, and assigning component types to machines to balance workload. The line assignment models are formulated as large scale mixed integer programming problems and are solved using a branch-and-bound algorithm, supplemented by techniques for improving the solution time. The models and solution approaches are demonstrated using industry representative data sets and can serve as useful decision support tools for process planning engineers.
Master of Science