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Author: Grafiati

Published: 10 March 2023

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1

Webber, Declan, Jingjing Cao, Daniela Dominguez, Dafna D. Gladman, Deborah M. Levy, Lawrence Ng, Andrew D. Paterson, et al. "Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE." Rheumatology 59, no. 1 (June 24, 2019): 90–98. http://dx.doi.org/10.1093/rheumatology/kez220.

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Abstract Objective LN is one of the most common and severe manifestations of SLE. Our aim was to test the association of SLE risk loci with LN risk in childhood-onset SLE (cSLE) and adult-onset SLE (aSLE). Methods Two Toronto-based tertiary care SLE cohorts included cSLE (diagnosed <18 years) and aSLE patients (diagnosed ⩾18 years). Patients met ACR and/or SLICC SLE criteria and were genotyped on the Illumina Multi-Ethnic Global Array or Omni1-Quad arrays. We identified those with and without biopsy-confirmed LN. HLA and non-HLA additive SLE risk-weighted genetic risk scores (GRSs) were tested for association with LN risk in logistic models, stratified by cSLE/aSLE and ancestry. Stratified effect estimates were meta-analysed. Results Of 1237 participants, 572 had cSLE (41% with LN) and 665 had aSLE (30% with LN). Increasing non-HLA GRS was significantly associated with increased LN risk [odds ratio (OR) = 1.26; 95% CI 1.09, 1.46; P = 0.0006], as was increasing HLA GRS in Europeans (OR = 1.55; 95% CI 1.07, 2.25; P = 0.03). There was a trend for stronger associations between both GRSs and LN risk in Europeans with cSLE compared with aSLE. When restricting cases to proliferative LN, the magnitude of these associations increased for both the non-HLA (OR = 1.30; 95% CI 1.10, 1.52; P = 0.002) and HLA GRS (OR = 1.99; 95% CI 1.29, 3.08; P = 0.002). Conclusion We observed an association between known SLE risk loci and LN risk in children and adults with SLE, with the strongest effect observed among Europeans with cSLE. Future studies will include SLE-risk single nucleotide polymorphisms specific to non-European ancestral groups and validate findings in an independent cohort.

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Mahendraker, Venkatram, Donald S. Mavinic, and Barry Rabinowitz. "Comparison of Oxygen Transfer Parameters from Four Testing Methods in Three Activated Sludge Processes." Water Quality Research Journal 40, no. 2 (May 1, 2005): 164–76. http://dx.doi.org/10.2166/wqrj.2005.019.

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Abstract In this investigation, the mass transfer of oxygen was determined using four different testing methods in three activated sludge processes, as per the guidelines established by the American Society of Civil Engineers (ASCE 1997). The testing methods applied included the steady-state oxygen uptake rate (OUR), the non-steady-state changing power level (CPL), the non-steady-state hydrogen peroxide addition (HPA) and the off-gas methods. The analysis indicated that steady-state OUR and off-gas methods resulted in comparable estimates of oxygen transfer parameters, with somewhat higher variations observed in the data from the off-gas method. The application of HPA and CPL methods produced variable results under the same process conditions and these testing methods affected the process. Based on the comparative evaluation conducted in these controlled experiments, the validity of HPA and CPL tests to measure the oxygen transfer under process conditions is questionable. Overall, the off-gas method appears to be superior, as it does not require steady-state process conditions. However, under suitable conditions the steady-state OUR method may be an economical option to study oxygen transfer under process conditions.

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Lin, Xin, Ermelina Enriquez, Jigar Patel, Ruth Huang, Cindi Marks, Sunitha Vege, KL Billingsley, Joann M. Moulds, and Ghazala Hashmi. "Universal DNA Arrays for High-Throughput SNP Detection of Human Platelet Antigens (HPA)." Blood 116, no. 21 (November 19, 2010): 4403. http://dx.doi.org/10.1182/blood.v116.21.4403.4403.

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Abstract Abstract 4403 Background: DNA analysis of human platelet antigens is known to improve the diagnosis and treatment of neonatal alloimmune thrombocytopenia and minimize the risks of post transfusion purpura and refractoriness to random donor platelet therapy. The availability of reliable molecular platforms such as HPA eMAP assays analyzing HPA-1, -2, -3, -4, -5, -6, -7, -8, -9, -11, and -15, are routinely used and eliminate the need for reference sera or large platelet volumes. New generations of HPA assays (HPA eMAP-S Beadchip™ Kit) described here are developed by identification of specific allele in solution and detection of targets by a generic probe array called the Universal BeadChip™ by imaging, HPA-13 was also incorporated in the panel. These assays are easily automatable due to fewer protocol steps. Methods: The BioArray Solutions HPA eMAP-S BeadChip Kit uses the novel Elongation Mediated Multiplexed Analysis of Polymorphisms in Solution (eMAP-S) technology (Lin, X., et al., 2010) to identify the presence or absence of the selected alleles associated with a given phenotype. We amplified 10 DNA fragments covering 12 allele variants which are associated with 12 platelet antigens by using multiplex PCR and HPA gene specific primer pairs. PCR was followed by multiplex allele specific primer extension (ASPE) and Beadchip detection by using the AIS-400 Array Imaging System. To evaluate the overall performance of HPA eMAP-S BeadChip™ Kits, a total 552 clinical samples with known HPA eMAP phenotype and/or serology were analyzed to determine polymorphisms associated with common human platelet antigen (HPA-1, -2, -3, -5, -15) and less common human platelet antigen (HPA-4, -6, -7, -8, -9, -11, -13). For internal study, 176 clinical samples were analyzed at BioArray Solutions (BAS). For the external study, 186 and 190 (total 376) donor samples were tested at two sites and analyzed by BASIS™ software. Phenotype results obtained from the HPA eMAP-S Beadchip™ Kit during the studies were compared to the data generated from the HPA eMAP BeadChip™ Kit and/or serology. Results: For internal and external studies, the concordance between the HPA eMAP-S Beadchip™ kit and HPA eMAP Beadchip™ kit was 99.99%. The discordant call (0.01%) on HPA-1b antigen was investigated. One HPA-1 discordant sample was sent out for sequencing and re-analyzed by using increased amount of DNA from DNA precipitation. The result from sequencing is consistent with the result from HPA eMAP Beadchip™ Kit. The HPA eMAP-S result from higher concentration DNA is also consistent with the result of sequencing. The discordance in the original HPA eMAP-S assay was attributed to less DNA input in the multiplex PCR, which will be corrected in the Package Insert of HPA eMAP-S Beadchip™ Kit. Conclusion: HPA eMAP-S Beadchip™ Kit could be used reliably for the determination of human platelet antigens using DNA analysis. Disclosures: Hashmi: Immucor: Employment.

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Nesterenko, V. A., A. E. Karateev, M. A. Makarov, E. I. Byalik, S. A. Makarov, and A. M. Lila. "Comparison of the effectiveness of subacromial administration of platelet-rich plasma and hyaluronic acid in chronic shoulder pain caused by damage to the tendons of the rotator cuff muscles according to a 6-month open clinical study." Rheumatology Science and Practice 58, no. 5 (November 9, 2020): 570–76. http://dx.doi.org/10.47360/1995-4484-2020-570-576.

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Local injections of platelet-rich plasma (PRP) and hyaluronic acid (HLA) are considered an effective method for treating chronic shoulder pain (CSP) associated with damage to the tendons of the rotator cuff muscles (RCM).The aim of the study is to compare the effectiveness and safety of local therapy of PRP and HLA in patients with CSP caused by damage to the tendons of the RCM muscles.Materials and methods. The study included 100 patients (54% women and 46% men, average age 51.5±15.1 years) with CSP (persisting for ≥3 months) associated with damage and tendinitis of the supraspinatus, subacute, scapular or small round muscle, confirmed by magnetic resonance imaging or ultrasound (ultrasound). The patients were randomized into two groups of 50 people who were treated with PRP (three injections at 7-day intervals) or HLA (two injections at 7-day intervals). The injections were performed under ultrasound control in the subacromial SAC. The results of the study were evaluated by the dynamics of pain intensity (on a visual analog scale, up to 100 mm) and functional disorders (ASES and CSS indices) after 1, 3 and 6 months.Results. Against the background of the use of PRP and HLA, there was a significant improvement in the condition of patients, while both drugs showed approximately the same effectiveness. The severity of VAS pain decreased from 56.8±15, respectively, after 6 months.5 and 57.6±17.8 mm to 31.8±27.8 and 30.2±26.3 mm, ASES-c 55.8±15.9 and 53.6±14.7 to 74.6±22.4 and 77.3± 22.4, CSS-c 59.2±14.4 and 47.8±16.9 to 69.9±17.3 and 65.6±19.2. the Dynamics of all these indicators in comparison with the baseline level was statistically significant (p<0.001). Number of patients with moderate / mild pain (<40 mm VAS) after 6 months. after the introduction of PRP and HLA was 48% and 60%, requiring regular NSAID intake 30% and 28%, respectively. In all parameters, the difference in the effectiveness of PRP and HLC was not statistically significant (p>0.05). The effectiveness of PRP and HLA (in terms of pain dynamics, ASES, and CSS) was significantly higher in individuals younger than 45 years, compared to older patients. The tolerability of therapy was good – after the introduction of PRP, 40% of patients had a short-term (3–4 days) increase in pain, which did not require the use of additional analgesics or interruption of treatment. No serious adverse reactions were observed when using PRP and HLA.Conclusion. OTP and GLA are effective and safe in the treatment of CSP associated with damage to the tendons of the RCM muscles. The dynamics of pain intensity and functional status after the use of these drugs did not differ. Treatment of PRP and HLA is more effective in people younger than 45 years.

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Holcar, Marija, Aleš Goropevšek, and Tadej Avčin. "Altered Homeostasis of Regulatory T Lymphocytes and Differential Regulation of STAT1/STAT5 in CD4+ T Lymphocytes in Childhood-onset Systemic Lupus Erythematosus." Journal of Rheumatology 47, no. 4 (July 1, 2019): 557–66. http://dx.doi.org/10.3899/jrheum.181418.

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Objective.Childhood-onset systemic lupus erythematosus (cSLE) is usually a more severe and aggressive disease than adult-onset SLE (aSLE), but cellular and subcellular reasons for these differences are not well understood. The present study analyzed Th subsets, STAT1/STAT5 signaling response, and cytokine profiles of cSLE.Methods.FOXP3+ regulatory (Treg) and effector Th subsets, expression and phosphorylation of STAT1/STAT5 in Th, and cytokine profiles were measured in the peripheral blood of patients with cSLE and healthy controls (HC), using flow cytometry and immunoassay on a biochip.Results.Significant correlation between expression of the activation marker HLA-DR and decreased Th counts, an increase in the percentage of FOXP3+ Th, and a decrease in the activated Treg (aTreg) subset among them were found in cSLE. In contrast to our previous findings in aSLE, no significant differences in percentages and a significant decrease in the numbers of the naive-resting Treg (rTreg) subset compared to HC were found. The percentages of CD25− cells, possibly reflecting interleukin 2 depletion, were significantly increased in cSLE aTreg, but not in the rTreg subset. Consistent with the results of our previous studies in aSLE, increased expression of STAT1, along with significant correlation between decreased Th counts and their increased basal phosphorylation of STAT5, were also found in cSLE.Conclusion.Our results suggest that the key difference in Treg homeostasis between cSLE and aSLE is in the rTreg subset. However, perturbed aTreg homeostasis, increased levels of STAT1 protein, and homeostatic STAT5 signaling appear to be intrinsic characteristics of the disease, present in cSLE and aSLE alike.

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Soriano-Sexto, Alejandro, Diana Gallego, Fátima Leal, Natalia Castejón-Fernández, Rosa Navarrete, Patricia Alcaide, María L. Couce, et al. "Identification of Clinical Variants beyond the Exome in Inborn Errors of Metabolism." International Journal of Molecular Sciences 23, no. 21 (October 25, 2022): 12850. http://dx.doi.org/10.3390/ijms232112850.

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Inborn errors of metabolism (IEM) constitute a huge group of rare diseases affecting 1 in every 1000 newborns. Next-generation sequencing has transformed the diagnosis of IEM, leading to its proposed use as a second-tier technology for confirming cases detected by clinical/biochemical studies or newborn screening. The diagnosis rate is, however, still not 100%. This paper reports the use of a personalized multi-omics (metabolomic, genomic and transcriptomic) pipeline plus functional genomics to aid in the genetic diagnosis of six unsolved cases, with a clinical and/or biochemical diagnosis of galactosemia, mucopolysaccharidosis type I (MPS I), maple syrup urine disease (MSUD), hyperphenylalaninemia (HPA), citrullinemia, or urea cycle deficiency. Eight novel variants in six genes were identified: six (four of them deep intronic) located in GALE, IDUA, PTS, ASS1 and OTC, all affecting the splicing process, and two located in the promoters of IDUA and PTS, thus affecting these genes’ expression. All the new variants were subjected to functional analysis to verify their pathogenic effects. This work underscores how the combination of different omics technologies and functional analysis can solve elusive cases in clinical practice.

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Lin, Xin, Ermelina Enriquez, Dipika B. Patel, Jigar Patel, Yuhua Song, Yi Zhang, and Ghazala Hashmi. "BeadChip-Human Erythrocyte Antigen Determination for Leukoreduced Blood." Blood 116, no. 21 (November 19, 2010): 1120. http://dx.doi.org/10.1182/blood.v116.21.1120.1120.

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Abstract Abstract 1120 Background: Leukoreduction (LR) is a process by which leukocytes (WBC) are filtered from blood or blood component, as the leukocytes may increase the incidence of alloimmunization to human leukocyte antigens and may cause febrile nonhemolytic adverse transfusion reactions. Current transfusion practice also requires that, at minimum, blood selected for transfusion to a patient be checked (phenotyped) to be antigen negative to the existing alloantibodies in the patient's serum. Human Erythrocyte Antigen (HEA) Beadchip™ (Hashmi, G. et al. Transfusion, 47, April 2007, 736–747) has been adopted by blood centers and transfusion services for routine antigen-negative screening. A recent prospective study (Klapper, E. et al. Transfusion, 50, March 2010, 536–546) conducted in four large hospital transfusion services concluded that it is theoretically feasible to establish an inventory of DNA tested donor components from existing hospital inventories to result in the provision of more extensively matched RBC components than is the current standard of practice. Here described is a HEA LR eMAP-S BeadChip™ platform developed based on a combination of a novel DNA extraction protocol and a novel proprietary assay platform for Human Erythrocyte Antigens determination from leukoreduced blood samples. Methods: The BioArray Solutions HEA LR eMAP-S BeadChip Kit uses the novel Elongation Mediated Multiplexed Analysis of Polymorphisms in Solution (eMAP-S) technology (Lin, X. et al., 2010). The multiplex PCR amplifies 21 DNA fragments covering 24 allele variants associated with 32 human erythrocyte antigens plus one mutation for hemoglobin S. The PCR, is then followed by clean-up, multiplex allele specific primer extension (ASPE), and on-Beadchip™ detection and read-out by using the AIS-400 Array Imaging System. Verification studies was performed using 203 leukoreduced blood segments collected from various blood centers and transfusion services in US. A set of 30 blood samples was also obtained from before leukoreduction (whole blood, WBC count: 2308–6052 cells/ μL) and after leukoreduction (LR blood, WBC count:0.36-2.63 cells/μL), DNAs from LR blood samples were extracted by a novel DNA extraction method (BAS) using commercial reagents ((Qiagen, Inc., Valencia, CA). To evaluate the performance of HEA LR eMAP-S Beadchip™ Kit, the extracted DNA samples from before and after LR were analyzed by both HEA LR eMAP-S Beadchip™ and commercially available HEA 1.2 Beadchip™ Kit along with 88 whole blood DNA samples and positive controls with known HEA calls and analyzed for 10 red blood group systems (Rh, K, JK, FY, MNS, DO, Lu, Yt, Di, Co); and one mutation associated with hemoglobinopathies. Phenotype results obtained from HEA LR eMAP-S BeadChip™ Kit during the studies were compared to the data from the HEA 1.2 BeadChip™ Kit. Results: DNA was successfully extracted from 30 donor DNA samples before (DNA ng/ul: 20–56) and after LR (DNA ng/ul: 8–20) and analyzed using HEA LR eMAP-S Beadchip™ Kit with 100% concordance in HEA phenotype results. The WB DNAs were further analyzed using HEA 1.2 Beadchip™ kit and the results showed 100% concordance with LR DNA results. In addition, results from positive controls (HEA Ref-pA, HEA Ref-pB and cell line DNAs) all produced correct calls, and HEA LR eMAP-S assay and HEA 1.2 assay testing results on 88 donor whole-blood DNAs showed 100% concordance. Conclusion: HEA LR eMAP-S Beadchip™ Kit could be used for reliable determination of human erythrocyte antigens for leukoreduced blood samples. Disclosures: No relevant conflicts of interest to declare.

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Ihara, Yasuo, Kenichi Aoki, Katsushi Tokunaga, Koki Takahashi, and Takeo Juji. "HLA and Human Mate Choice. Tests on Japanese Couples." Anthropological Science 108, no. 2 (2000): 199–214. http://dx.doi.org/10.1537/ase.108.199.

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Sánchez-Leal, Freddy J., Paul Garnica Anguas, Michael Larreal, and Diana B. López Valdés. "Polyvoids: Analytical Tool for Superpave HMA Design." Journal of Materials in Civil Engineering 23, no. 8 (August 2011): 1129–37. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000275.

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Mamlouk, Michael, and Mena I. Souliman. "Reducing Inconsistency of HMA Flexure Fatigue Testing." Journal of Materials in Civil Engineering 28, no. 2 (February 2016): 04015131. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0001422.

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Tarasenko, Olga, Jun Ohashi, Yuji Ataka, Tsukasa Inaoka, Ryutaro Ohtsuka, and Katsushi Tokunaga. "HLA-DRB1 Polymorphism of Balopa Islanders in Papua New Guinea." Anthropological Science 111, no. 2 (2003): 157–64. http://dx.doi.org/10.1537/ase.111.157.

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Gopalakrishnan, Kasthurirangan, and Sunghwan Kim. "Support Vector Machines Approach to HMA Stiffness Prediction." Journal of Engineering Mechanics 137, no. 2 (February 2011): 138–46. http://dx.doi.org/10.1061/(asce)em.1943-7889.0000214.

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OHASHI, JUN, IZUMI NAKA, RYOSUKE KIMURA, KATSUSHI TOKUNAGA, MINATO NAKAZAWA, YUJI ATAKA, RYUTARO OHTSUKA, TSUKASA INAOKA, and YASUHIRO MATSUMURA. "HLA-DRB1 polymorphism on Ha’ano island of the Kingdom of Tonga." Anthropological Science 114, no. 3 (2006): 193–98. http://dx.doi.org/10.1537/ase.050907.

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Tarasenko, Olga, Jun Ohashi, Mikhail Kitaev, Avtandil Alisherov, Bakhtygul Tyurebaeva, Toktogazy Kutukeev, and Katsushi Tokunaga. "Polymorphisms of HLA-A and -B Genes in the Kyrgyz Population." Anthropological Science 108, no. 4 (2000): 293–303. http://dx.doi.org/10.1537/ase.108.293.

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Cao, Weidong, Shutang Liu, Zhichao Xue, Luchuan Chen, and Zhidong Zhang. "Laboratory Method to Characterize Coarse Aggregate Segregation for HMA." Journal of Materials in Civil Engineering 33, no. 1 (January 2021): 04020412. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0003522.

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Drieu, Cloé. "L'impact de la Première Guerre mondiale en Asie centrale : des révoltes de 1916 aux enjeux politiques et scientifiques de leur historiographie." Histoire@Politique 22, no. 1 (2014): 175. http://dx.doi.org/10.3917/hp.022.0175.

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Al-Hadidy, A. I. "Performance of SBS-HMA Mixes Made with Sasobit and Zeolite." Journal of Materials in Civil Engineering 32, no. 10 (October 2020): 06020017. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0003362.

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Kim Dong-shik. "The unconsciousness of 'kkini'(meal) and the Korean literature of 1920s : Choi Seo-hea and Kim Ki-jin." Literature and Environment 11, no. 1 (June 2012): 175–205. http://dx.doi.org/10.36063/asle.2012.11.1.008.

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Haghshenas, H. F., A. Khodaii, M. Hossain, and D. S. Gedafa. "Stripping Potential of HMA and SMA: A Study Using Statistical Approach." Journal of Materials in Civil Engineering 27, no. 11 (November 2015): 06015002. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0001266.

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Huang, Baoshan, Xiang Shu, Guoqiang Li, and Leishan Chen. "Analytical Modeling of Three-Layered HMA Mixtures." International Journal of Geomechanics 7, no. 2 (March 2007): 140–48. http://dx.doi.org/10.1061/(asce)1532-3641(2007)7:2(140).

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Hajj, Elie Y., Peter E. Sebaaly, and Pratheepan Kandiah. "Evaluation of the Use of Reclaimed Asphalt Pavement in Airfield HMA Pavements." Journal of Transportation Engineering 136, no. 3 (March 2010): 181–89. http://dx.doi.org/10.1061/(asce)te.1943-5436.0000090.

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Che, Tiankai, Baofeng Pan, Dong Sha, Yuanteng Zhang, and Zhanping You. "Relationship between Air Voids and Permeability: Effect on Water Scouring Resistance in HMA." Journal of Materials in Civil Engineering 33, no. 4 (April 2021): 04021022. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0003642.

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Othman, Ayman M. "Impact of Polypropylene Application Method on Long-Term Aging of Polypropylene-Modified HMA." Journal of Materials in Civil Engineering 22, no. 10 (October 2010): 1012–18. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000105.

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Van Winkle, Clinton, Ali Mokhtari, Hosin “David” Lee, R. Christopher Williams, and Scott Schram. "Laboratory and Field Evaluation of HMA with High Contents of Recycled Asphalt Pavement." Journal of Materials in Civil Engineering 29, no. 2 (February 2017): 04016196. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0001720.

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Chen, Siyu, Sanjeev Adhikari, and Zhanping You. "Relationship of Coefficient of Permeability, Porosity, and Air Voids in Fine-Graded HMA." Journal of Materials in Civil Engineering 31, no. 1 (January 2019): 04018359. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0002573.

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Sebaaly, Peter E., Andrew Lake, and Jon Epps. "Evaluation of Low-Temperature Properties of HMA Mixtures." Journal of Transportation Engineering 128, no. 6 (November 2002): 578–86. http://dx.doi.org/10.1061/(asce)0733-947x(2002)128:6(578).

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Walubita, Lubinda F., Luis Fuentes, Hossain Tanvir, Harshavardhan R. Chunduri, and Samer Dessouky. "Correlating the Asphalt-Binder BBR Test Data to the HMA (ML-OT) Fracture Properties." Journal of Materials in Civil Engineering 33, no. 9 (September 2021): 04021230. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0003866.

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Krishna Swamy, Aravind, Luke F. Mitchell, Steven J. Hall, and Jo Sias Daniel. "Impact of RAP on the Volumetric, Stiffness, Strength, and Low-Temperature Properties of HMA." Journal of Materials in Civil Engineering 23, no. 11 (November 2011): 1490–97. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000245.

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Mohammad, Louay N., Samuel B. Cooper, and Mostafa A. Elseifi. "Characterization of HMA Mixtures Containing High Reclaimed Asphalt Pavement Content with Crumb Rubber Additives." Journal of Materials in Civil Engineering 23, no. 11 (November 2011): 1560–68. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000359.

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Zeiada, Waleed A., Mena I. Souliman, Kamil E. Kaloush, and Michael Mamlouk. "Endurance Limit for HMA Based on Healing Concept Using Uniaxial Tension-Compression Fatigue Test." Journal of Materials in Civil Engineering 26, no. 8 (August 2014): 04014036. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000917.

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Rushing, John F., and Dallas N. Little. "Static Creep and Repeated Load as Rutting Performance Tests for Airport HMA Mix Design." Journal of Materials in Civil Engineering 26, no. 9 (September 2014): 04014055. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000952.

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Goh, Shu Wei, Zhanping You, R. Christopher Williams, and Xinjun Li. "Preliminary Dynamic Modulus Criteria of HMA for Field Rutting of Asphalt Pavements: Michigan’s Experience." Journal of Transportation Engineering 137, no. 1 (January 2011): 37–45. http://dx.doi.org/10.1061/(asce)te.1943-5436.0000191.

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Tashman, Laith, and Muthukumaran Elangovan. "Dynamic Modulus of HMA and Its Relationship to Actual and Predicted Field Performance Using MEPDG." Journal of Performance of Constructed Facilities 27, no. 3 (June 2013): 334–45. http://dx.doi.org/10.1061/(asce)cf.1943-5509.0000328.

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Cook, Karissa, Navneet Garg, Amarjit Singh, and Murphy Flynn. "Detection of Delamination in the HMA Layer of Runway Pavement Structure Using Asphalt Strain Gauges." Journal of Transportation Engineering 142, no. 11 (November 2016): 04016047. http://dx.doi.org/10.1061/(asce)te.1943-5436.0000869.

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Yun, Taeyoung, B. Shane Underwood, and Y. Richard Kim. "Time-Temperature Superposition for HMA with Growing Damage and Permanent Strain in Confined Tension and Compression." Journal of Materials in Civil Engineering 22, no. 5 (May 2010): 415–22. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000039.

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Zhang, Yang, Simaan M. AbouRizk, Hua Xie, and Elmira Moghani. "Design and Implementation of Loose-Coupling Visualization Components in a Distributed Construction Simulation Environment with HLA." Journal of Computing in Civil Engineering 26, no. 2 (March 2012): 248–58. http://dx.doi.org/10.1061/(asce)cp.1943-5487.0000131.

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Hu, Sheng, Fujie Zhou, and Tom Scullion. "Development, Calibration, and Validation of a New M-E Rutting Model for HMA Overlay Design and Analysis." Journal of Materials in Civil Engineering 23, no. 2 (February 2011): 89–99. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0000130.

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Hua, J., and T. White. "A Study of Nonlinear Tire Contact Pressure Effects on HMA Rutting." International Journal of Geomechanics 2, no. 3 (July 2002): 353–76. http://dx.doi.org/10.1061/(asce)1532-3641(2002)2:3(353).

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Rabiepour, Mohammad, Cong Zhou, and James Geoffrey Chase. "Evaluation of Pinching Effects on a Real Concrete Building Seismic Performance by Resimulating Displacement Responses Using HLA SHM Results." Journal of Performance of Constructed Facilities 35, no. 4 (August 2021): 04021024. http://dx.doi.org/10.1061/(asce)cf.1943-5509.0001602.

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Zhou, Fujie, Sheng Hu, Xiaodi Hu, Tom Scullion, Magdy Mikhail, and Lubinda F. Walubita. "Development, Calibration, and Verification of a New Mechanistic-Empirical Reflective Cracking Model for HMA Overlay Thickness Design and Analysis." Journal of Transportation Engineering 136, no. 4 (April 2010): 353–69. http://dx.doi.org/10.1061/(asce)te.1943-5436.0000096.

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Shen, Der-Hsien, and Jia-Chong Du. "Application of Gray Relational Analysis to Evaluate HMA with Reclaimed Building Materials." Journal of Materials in Civil Engineering 17, no. 4 (August 2005): 400–406. http://dx.doi.org/10.1061/(asce)0899-1561(2005)17:4(400).

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Shu, Xiang, and Baoshan Huang. "Dynamic Modulus Prediction of HMA Mixtures Based on the Viscoelastic Micromechanical Model." Journal of Materials in Civil Engineering 20, no. 8 (August 2008): 530–38. http://dx.doi.org/10.1061/(asce)0899-1561(2008)20:8(530).

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Karimi, Sahand S., Dimitrios G. Goulias, and Charles W. Schwartz. "Evaluation of Superpave HMA Mixture Properties at the Plant versus behind the Paver: Statistical Comparison of QC and QA Data." Journal of Transportation Engineering 138, no. 7 (July 2012): 924–32. http://dx.doi.org/10.1061/(asce)te.1943-5436.0000399.

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Khanghahi, Siyab Houshmandi, and Ahmet Tortum. "Determination of the Optimum Conditions for Gilsonite and Glass Fiber in HMA under Mixed Mode I/III Loading in Fracture Tests." Journal of Materials in Civil Engineering 30, no. 7 (July 2018): 04018130. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0002278.

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Shen, Yang, Jian Zhou, and Xiao Nan Gong. "Possible Stress Path of HCA for Cyclic Principal Stress Rotation under Constant Confining Pressures." International Journal of Geomechanics 7, no. 6 (November 2007): 423–30. http://dx.doi.org/10.1061/(asce)1532-3641(2007)7:6(423).

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Carter, Alan, and Mary Stroup-Gardiner. "Indirect Tension Relaxation Test to Evaluate the Effect of the Addition of RAP to HMA Mixes." Journal of Materials in Civil Engineering 19, no. 3 (March 2007): 219–26. http://dx.doi.org/10.1061/(asce)0899-1561(2007)19:3(219).

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Bozhko, A. N. "Structural Analysis of Product and Computer-Aided Assembly Planning in AssemBL Software Package." Mechanical Engineering and Computer Science, no. 8 (October 22, 2018): 11–33. http://dx.doi.org/10.24108/0818.0001424.

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Computer-aided design of assembly processes (Computer aided assembly planning, CAAP) of complex products is an important and urgent problem of state-of-the-art information technologies. Intensive research on CAAP has been underway since the 1980s. Meanwhile, specialized design systems were created to provide synthesis of assembly plans and product decompositions into assembly units. Such systems as ASPE, RAPID, XAP / 1, FLAPS, Archimedes, PRELEIDES, HAP, etc. can be given, as an example. These experimental developments did not get widespread use in industry, since they are based on the models of products with limited adequacy and require an expert’s active involvement in preparing initial information. The design tools for the state-of-the-art full-featured CAD/CAM systems (Siemens NX, Dassault CATIA and PTC Creo Elements / Pro), which are designed to provide CAAP, mainly take into account the geometric constraints that the design imposes on design solutions. These systems often synthesize technologically incorrect assembly sequences in which known technological heuristics are violated, for example orderliness in accuracy, consistency with the system of dimension chains, etc.An AssemBL software application package has been developed for a structured analysis of products and a synthesis of assembly plans and decompositions. The AssemBL uses a hyper-graph model of a product that correctly describes coherent and sequential assembly operations and processes. In terms of the hyper-graph model, an assembly operation is described as shrinkage of edge, an assembly plan is a sequence of shrinkages that converts a hyper-graph into the point, and a decomposition of product into assembly units is a hyper-graph partition into sub-graphs.The AssemBL solves the problem of minimizing the number of direct checks for geometric solvability when assembling complex products. This task is posed as a plus-sum two-person game of bicoloured brushing of an ordered set. In the paradigm of this model, the brushing operation is to check a certain structured fragment for solvability by collision detection methods. A rational brushing strategy minimizes the number of such checks.The package is integrated into the Siemens NX 10.0 computer-aided design system. This solution allowed us to combine specialized AssemBL tools with a developed toolkit of one of the most powerful and popular integrated CAD/CAM /CAE systems.

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Dominguez, Daniela, Sylvia Kamphuis, Joseph Beyene, Joan Wither, John B. Harley, Irene Blanco, Catarina Vila-Inda, et al. "Relationship between Genetic Risk and Age of Diagnosis of Systemic Lupus Erythematosus." Journal of Rheumatology, October 15, 2020, jrheum.200002. http://dx.doi.org/10.3899/jrheum.200002.

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Objective Specific risk alleles for childhood-onset SLE (cSLE) versus adult-onset SLE (aSLE) patients have not been identified. The aims of this study were to determine if: 1) There is an association between non-HLA-related genetic risk score (GRS) and age of SLE diagnosis; and if 2) There is an association between HLA-related genetic risk score and age of SLE diagnosis. Methods Genomic DNA was obtained from 2,001 multi-ethnic patients and genotyped using the Immunochip. Following quality control, genetic risk counting (GRCS), weighted (GRWS) and standardized counting (GRSCS) and standardized weighted (GRSWS) scores were calculated based on independent SNPs from validated SLE-loci. Scores were analyzed in a regression model and adjusted by sex and ancestral population. Results The analysed cohort consisted of 1,540 patients: 1,351 females and 189 males (675 cSLE and 865 aSLE). There were significant negative associations with age of SLE diagnosis p=0.011 and r2=0.175 for GRWS, p=0.008 and r2=0.178 for GRSCS, p=0.002 and r2=0.176 for GRSWS for all non-HLA genetic risk scores (higher GRS the lower the age of diagnosis.) All HLA genetic risk scores showed significant positive associations with age of diagnosis p=0.049 and r2=0.176 for GRCS, p=0.022 and r2=0.176 for GRWS, p=0.022 and r2=0.176 for GRSCS, p=0.011 and r2=0.177 for GRSWS: higher genetic scores correlated with higher age of diagnosis. Conclusion Our data suggested that there is a linear relationship between genetic risk and age of SLE diagnosis and that HLA and non-HLA genetic risk scores are associated with age of diagnosis in opposite directions.

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Liu, Yunze, Lei Xu, Chuanchuan Hao, Jin Wu, Xianhong Jia, Xia Ding, Changwei Lin, Hongmei Zhu, and Yi Zhang. "Identification and Validation of Novel Immune-Related Alternative Splicing Signatures as a Prognostic Model for Colon Cancer." Frontiers in Oncology 12 (May 26, 2022). http://dx.doi.org/10.3389/fonc.2022.866289.

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BackgroundIndividual immune-related alternative splicing (AS) events have been found to be significant in immune regulation and cancer prognosis. However, a comprehensive analysis of AS events in cancer cells based on immune-related genes (IRGs) has not been performed, and its clinical value is unknown.MethodsColon cancer cases with AS data were obtained from TCGA, and then, we identified overall survival-related AS events (OS-ASEs) based on IRGs by univariate analyses. Using Lasso regression, multivariate Cox regression, Kaplan–Meier analysis and nomograms, we constructed an AS risk model based on the calculated risk score. Furthermore, associations of the risk score with clinical and immune features were confirmed through the Wilcoxon rank sum test, association analysis, etc. Finally, by qRT–PCR, cell coculture and CCK-8 analyses, we validated the significance of OS-ASEs in colon cancer cell lines and clinical samples.ResultsA total of 3,119 immune-related AS events and 183 OS-ASEs were identified, and 9 OS-ASEs were ultimately used to construct a comprehensive risk model for colon cancer patients. Low-risk patients had better OS and DFS rates than high risk patients. Furthermore, a high risk score corresponded to high numbers of multiple tumour-infiltrating immune cells and high expression of HLA-D region genes and immune checkpoint genes. Notably, we identified for the first time that anti-PD-L1 or anti-CTLA-4 antibodies may decrease the OS of specific colon cancer patients in the low-risk group. Additionally, the in vitro experiment validated that CD46-9652-ES and PSMC5-43011-ES are positively correlated with the infiltration of immune cells and promote the growth of colon cancer cells. CD46-9652-ES can contribute to T cell-mediated tumour cell killing. PSMC5-43011-ES was observed to induce M2 polarization of macrophages.ConclusionsThis study identified and validated immune-related prognostic AS signatures that can be used as a novel AS prognostic model and provide a novel understanding of the relationship between the immune microenvironment and clinical outcomes.

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Putscher, Elena, Michael Hecker, Brit Fitzner, Nina Boxberger, Margit Schwartz, Dirk Koczan, Peter Lorenz, and Uwe Klaus Zettl. "Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing." Frontiers in Immunology 13 (October 28, 2022). http://dx.doi.org/10.3389/fimmu.2022.931831.

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BackgroundMultiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system to which a genetic predisposition contributes. Over 200 genetic regions have been associated with increased disease risk, but the disease-causing variants and their functional impact at the molecular level are mostly poorly defined. We hypothesized that single-nucleotide polymorphisms (SNPs) have an impact on pre-mRNA splicing in MS.MethodsOur study focused on 10 bioinformatically prioritized SNP–gene pairs, in which the SNP has a high potential to alter alternative splicing events (ASEs). We tested for differential gene expression and differential alternative splicing in B cells from MS patients and healthy controls. We further examined the impact of the SNP genotypes on ASEs and on splice isoform expression levels. Novel genotype-dependent effects on splicing were verified with splicing reporter minigene assays.ResultsWe were able to confirm previously described findings regarding the relation of MS-associated SNPs with the ASEs of the pre-mRNAs from GSDMB and SP140. We also observed an increased IL7R exon 6 skipping when comparing relapsing and progressive MS patients to healthy subjects. Moreover, we found evidence that the MS risk alleles of the SNPs rs3851808 (EFCAB13), rs1131123 (HLA-C), rs10783847 (TSFM), and rs2014886 (TSFM) may contribute to a differential splicing pattern. Of particular interest is the genotype-dependent exon skipping of TSFM due to the SNP rs2014886. The minor allele T creates a donor splice site, resulting in the expression of the exon 3 and 4 of a short TSFM transcript isoform, whereas in the presence of the MS risk allele C, this donor site is absent, and thus the short transcript isoform is not expressed.ConclusionIn summary, we found that genetic variants from MS risk loci affect pre-mRNA splicing. Our findings substantiate the role of ASEs with respect to the genetics of MS. Further studies on how disease-causing genetic variants may modify the interactions between splicing regulatory sequence elements and RNA-binding proteins can help to deepen our understanding of the genetic susceptibility to MS.

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