Academic literature on the topic 'Assay platform'
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Journal articles on the topic "Assay platform"
Chaby, Lauren E., Heather C. Lasseter, Kévin Contrepois, Reza M. Salek, Christoph W. Turck, Andrew Thompson, Timothy Vaughan, Magali Haas, and Andreas Jeromin. "Cross-Platform Evaluation of Commercially Targeted and Untargeted Metabolomics Approaches to Optimize the Investigation of Psychiatric Disease." Metabolites 11, no. 9 (September 8, 2021): 609. http://dx.doi.org/10.3390/metabo11090609.
Full textBosse, Roger, Russell Garlick, Beverly Brown, and Luc Menard. "Development of Nonseparation Binding and Functional Assays for G Protein-Coupled Receptors for High Throughput Screening: Pharmacological Characterization of the Immobilized CCR5 Receptor on FlashPlate(r)." Journal of Biomolecular Screening 3, no. 4 (June 1998): 285–92. http://dx.doi.org/10.1177/108705719800300407.
Full textCollet-Brose, Justine, Pierre-Jean Couble, Maureen R. Deehan, Robert J. Nelson, Walter G. Ferlin, and Sabrina Lory. "Evaluation of Multiple Immunoassay Technology Platforms to Select the Anti-Drug Antibody Assay Exhibiting the Most Appropriate Drug and Target Tolerance." Journal of Immunology Research 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/5069678.
Full textDunn, D., M. Orlowski, P. McCoy, F. Gastgeb, K. Appell, L. Ozgur, M. Webb, and J. Burbaum. "Ultra-High Throughput Screen of Two-Million-Member Combinatorial Compound Collection in a Miniaturized, 1536-Well Assay Format." Journal of Biomolecular Screening 5, no. 3 (June 2000): 177–87. http://dx.doi.org/10.1177/108705710000500310.
Full textThompson, Iain, John McGiven, Jason Sawyer, Rachel Thirlwall, Nicola Commander, and Judy Stack. "Competitive Electrochemiluminescence Wash and No-Wash Immunoassays for Detection of Serum Antibodies to Smooth Brucella Strains." Clinical and Vaccine Immunology 16, no. 5 (March 4, 2009): 765–71. http://dx.doi.org/10.1128/cvi.00006-09.
Full textZhao, Yanan, Yoji Nagasaki, Milena Kordalewska, Ellen G. Press, Ryan K. Shields, M. Hong Nguyen, Cornelius J. Clancy, and David S. Perlin. "Rapid Detection ofFKS-Associated Echinocandin Resistance in Candida glabrata." Antimicrobial Agents and Chemotherapy 60, no. 11 (August 22, 2016): 6573–77. http://dx.doi.org/10.1128/aac.01574-16.
Full textWard, Matthew D., Kristin E. Mullins, Elizabeth Pickett, VeRonika Merrill, Mark Ruiz, Heather Rebuck, Show-Hong Duh, and Robert H. Christenson. "Performance of 4 Automated SARS-CoV-2 Serology Assay Platforms in a Large Cohort Including Susceptible COVID-19–Negative and COVID-19–Positive Patients." Journal of Applied Laboratory Medicine 6, no. 4 (March 10, 2021): 942–52. http://dx.doi.org/10.1093/jalm/jfab014.
Full textSuhandynata, Raymond T., Melissa A. Hoffman, Michael J. Kelner, Ronald W. McLawhon, Sharon L. Reed, and Robert L. Fitzgerald. "Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detection of COVID-19." Journal of Applied Laboratory Medicine 5, no. 6 (August 7, 2020): 1324–36. http://dx.doi.org/10.1093/jalm/jfaa139.
Full textHemmila, Ilkka. "LANCE™: Homogeneous Assay Platform for HTS." Journal of Biomolecular Screening 4, no. 6 (December 1999): 303–7. http://dx.doi.org/10.1177/108705719900400604.
Full textChen, Fang-yuan, Zheng Wang, Peng Li, Hong-Zhen Lian, and Hong-Yuan Chen. "Aptamer-based thrombin assay on microfluidic platform." ELECTROPHORESIS 34, no. 24 (November 18, 2013): 3260–66. http://dx.doi.org/10.1002/elps.201300338.
Full textDissertations / Theses on the topic "Assay platform"
Harrison, Olivia Jane. "Integrated platform to assay melanoblast development in vitro." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31164.
Full textSun, Han. "Novel microfluidic platform for bioassays." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/699.
Full textSpetsare, Ebba. "Optimization of a pharmacokinetic assay in a bridging assay format using the Gyrolab immunoassay platform." Thesis, Uppsala universitet, Biokemi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396493.
Full textBucco, Olgatina, and olgatina@gmail com. "Preparing, measuring and capturing G-protein coupled receptor (GPCR) signalling complexes for future development of cell-free assay technologies." Flinders University. medicine, 2006. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20060703.114912.
Full textTothill, Alexander M. "Developing a proof of principle 3D-printed lab-on-a-disc assay platform." Thesis, Cranfield University, 2017. http://dspace.lib.cranfield.ac.uk/handle/1826/13496.
Full textIsmail, Awale Nasteho. "Validation of a tetraplex assay for detection of antibodies in poultry serum using Luminex 200 platform." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181920.
Full textCheow, Lih Feng. "Development of a concentration-enhanced mobility shift assay platform for aptamer-based biomarker detection and kinase profiling." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/71513.
Full textCataloged from PDF version of thesis.
Includes bibliographical references.
New methods to quantify rare biomarkers from patient samples are critical for developing point-of- care diagnostic platforms. To be compatible with resource limited settings, these assays have to provide fast and accurate results without sacrificing ease of use. Biosensing in homogeneous fashion is the preferred format which satisfies these criteria, but the lack of amplification method is a bottleneck that limits their use for sensitive applications. To address this issue, this thesis explores physical signal amplification means to increase the sensitivities of homogeneous assays. We identified several key applications where the use of these technologies could make a positive impact in improving medical diagnostics systems and advancing biological research. We first outline the use of electrokinetic concentration to realize a continuous signal amplification scheme that increases the sensitivity of homogeneous mobility shift assays. By simultaneously concentrating and separating reacted and unreacted species (with different mobilities) in this device, we can perform sensitive, quantitative and ratiometric measurement of target biomarkers. Using this platform, we improved the sensitivity of aptamer affinity probe capillary electrophoresis to achieve pM detection limit of IgE and HIV-RT in simple buffer and serum sample. This work is timely and impactful as it directly addresses the sensitivity shortcomings of using aptamers as low cost and robust substitutes for antibodies in point-of-care applications. Next, we presented a herringbone nanofilter array device which can perform continuous sizes-elective concentration of biomolecules based on their direct interaction with nanostructures with comparable critical dimensions. We demonstrated the use of this platform to perform a novel homogeneous immunoassay for detecting a cardiac biomarker, C-reactive protein, at clinically relevant concentrations. Finally, we demonstrated that the concentration-enhanced mobility shift assay platform is a powerful tool for probing biological activities such as cellular kinase activities. We have developed technology to isolate, grow and lyse single cells, and used our platform to measure kinase activities from single cells. Through rational design of peptide substrates and spacers, this platform has the ability to simultaneously concentrate and separate multiple analytes. This enables users to obtain simultaneous measurements of multiple cellular kinase activities that could reveal important information about their functional relationships.
by Lih Feng Cheow.
Ph.D.
Bracht-Loman, Jillian Wilhelmina Paulina. "Validation of liquid biopsy-based analysis on the NanoString nCounter platform." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672549.
Full textLa evaluación de los marcadores moleculares en tejido tumoral para el pronóstico del cáncer y la predicción de respuesta al tratamiento (lo que habitualmente se conoce como tratamiento personalizado) ha transformado la práctica clínica a la hora de tratar muchos tipos de cáncer. Son numerosos los trabajos que desde hace tiempo respaldan el efecto que esta terapia dirigida por genotipo tiene sobre los pacientes oncológicos mejorando la supervivencia del paciente; consecuentemente, un amplio rango de plataformas técnicas han sido implementadas en los laboratorios clínicos en los últimos años. Sin embargo, no todos los tumores se pueden biopsiar y, a menudo, las cantidades de tejido son insuficientes para la caracterización del tumor. Las biopsias líquidas, como el ARN, el ADN o las proteínas circulantes tanto libres como encapsuladas en una membrana, pueden extraerse de los fluidos corporales reemplazando o complementando de este modo las tradicionales biopsias de tejido. Las biopsias líquidas tienen varias ventajas: ofrecen la posibilidad de realizar estudios seriados, son mínimamente invasivas y permiten analizar la heterogeneidad tumoral. Desafortunadamente, todavía existe una gran brecha entre la investigación básica y la implementación clínica de las biopsias líquidas, principalmente debido a la falta de metodologías estandarizadas. Además, las plataformas técnicas que se utilizan actualmente no siempre son adecuadas para analizar la baja cantidad y calidad de material del tumor procedente de una biopsia líquida. En consecuencia, la validación e implementación de los ensayos de biomarcadores en biopsias líquidas en los laboratorios clínicos requieren una plataforma técnica estandarizada que sea sensible, rápida, fácil de usar, viable económicamente, flexible y que requiera un aporte inicial de ácidos nucleicos bajo, debido a la baja concentración que normalmente se obtiene en las biopsias líquidas. La plataforma nCounter se puede utilizar para analizar todo tipo de moléculas, incluyendo ARN, ADN y proteínas. La hibridación de diferentes códigos formados por moléculas de colores siguiendo patrones específicos con secuencias de interés permite una lectura directa de los niveles de expresión de genes y proteínas o la detección de mutaciones. El desarrollo de ensayos de biomarcadores en tejidos usando nCounter condujo a la aprobación por la administración de fármacos y alimentos de los Estados Unidos (FDA) del ensayo Prosigna ™ para su uso clínico en la tipificación del cáncer de mama. Numerosos estudios han destacado el potencial de esta plataforma para analizar moléculas derivadas y amplificadas de biopsias líquidas, aunque estudios de validación en el entorno clínico aun son necesarios. El objeto de esta tesis es la validación del uso de la plataforma NanoString nCounter para analizar material de biopsias líquidas y desarrollar ensayos de biomarcadores clínicamente relevantes.
The assessment of predictive- and prognostic molecular markers in tumor tissue, also known as personalised treatment, has transformed clinical practice for many cancer types. This genotype-directed therapy was found to improve patient survival, and several technical platforms have been introduced in clinical laboratories since then. However, not all tumors can be biopsied and tissue quantities are often insufficient for tumor characterisation. Liquid biopsies, such as membrane-encapsulated- or circulating free RNA, DNA and proteins, can be derived from body fluids and can replace or complement tissue biopsies. They have several advantages, such as repeated sampling, a minimally invasive character and heterogeneous profiling. Unfortunately, there is still a big gap between basic research and clinical implementation of liquid biopsies, mainly due to the lack of standardised methodologies. In addition, currently used technical platforms are not always suitable to analyze the low quantity and quality of tumor-derived material that can be found in a liquid biopsy. In consequence, large-scale validation and clinical implementation of liquid biopsy-based biomarker assays requires a sensitive, quick, easy-to-use, relatively cheap, flexible and standardized technical platform with low input requirements. The nCounter platform can be used to analyze all types of molecules, including RNA, DNA and proteins. Binding of color coded barcodes to targets of interest allows for either a direct read-out of gene- or protein expression levels or the detection of mutations. Tissue-based biomarker assay development on nCounter led to the FDA approval of the Prosigna™ assay for clinical use in breast cancer subtyping. Previous efforts have also highlighted the potential of this platform to analyze amplified liquid biopsy-derived molecules, although validation studies in the clinical setting are needed. In this thesis we validated the use of the NanoString nCounter platform to analyze material from liquid biopsies and develop clinically relevant biomarker assays.
Universitat Autònoma de Barcelona. Programa de Doctorat en Bioquímica, Biologia Molecular i Biomedicina
Vasou, Andri. "Development of a novel cell-based screening platform to identify inhibitors of viral interferon antagonists from clinically important viruses." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8266.
Full textNgema, Xolani Terrance. "Metallic nanoparticles with polymeric shell: A multifunctional platform for application to biosensor." University of the Western Cape, 2018. http://hdl.handle.net/11394/6330.
Full textTuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (MTB) that usually affects the lungs leading to severe coughing, fever and chest pains. It was estimated that over 9.6 million people worldwide developed TB and 1.5 million died from the infectious disease of which 12 % were co-infected with human immunodeficiency virus (HIV) in the year 2015. In 2016 the statistics increased to a total of 1.7 million people reportedly died from TB with an estimated 10.4 million new cases of TB diagnosed worldwide. The development of the efficient point-of-care systems that are ultra-sensitive, cheap and readily available is essential in order to address and control the spread of the tuberculosis (TB) disease and multidrugresistant tuberculosis.
Books on the topic "Assay platform"
Thomas, Ranjeny, and Andrew P. Cope. Pathogenesis of rheumatoid arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0109.
Full textBook chapters on the topic "Assay platform"
Ernst, David, George Bolton, Diether Recktenwald, Mark J. Cameron, Ali Danesh, Desmond Persad, David J. Kelvin, and Amitabh Gaur. "Bead-Based Flow Cytometric Assays: A Multiplex Assay Platform with Applications in Diagnostic Microbiology." In Advanced Techniques in Diagnostic Microbiology, 427–43. Boston, MA: Springer US, 2006. http://dx.doi.org/10.1007/0-387-32892-0_25.
Full textDaridon, Antoine, William Throndset, Ian Liau, Kevin Farrell, Flora Tseng, Shervin Javadi, and Ian Manger. "A Programmable Cell Assay Platform for Kinetic Studies of a Single Cell." In Micro Total Analysis Systems 2002, 31–33. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0295-0_10.
Full textBardelle, Catherine, and Joanna Boros. "ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform." In Methods in Molecular Biology, 57–70. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6955-5_5.
Full textBaldini, F., A. Giannetti, F. Senesi, C. Trono, L. Bolzoni, and G. Porro. "An Optical Platform Based on Fluorescence Anisotropy for C Reactive Protein and Procalcitonine Assay." In Lecture Notes in Electrical Engineering, 127–31. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3606-3_22.
Full textMcGuinness, Ryan P., Debra L. Gallant, Yen-Wen Chen, Trisha A. Tutana, Donna L. Wilson, John M. Proctor, and H. Roger Tang. "The CellKey® System: A Label-Free Cell-Based Assay Platform for Early Drug Discovery Applications." In Label-Free Technologies for Drug Discovery, 57–70. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979129.ch4.
Full textGuest, Paul C., Divya Krishnamurthy, and Hassan Rahmoune. "Development of an Assay for Measuring Proprotein-Conversion Activity on a Multiplex Magnetic Bead-Based Array Platform." In Advances in Experimental Medicine and Biology, 321–26. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52479-5_31.
Full textBell, David, and Theodoor Visser. "Malaria Diagnostic Platform: Lateral Flow Assays." In Encyclopedia of Malaria, 1–9. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-8757-9_105-1.
Full textSanyal, Suparna, and Marshall Kosovsky. "Materials and assay systems used for three-dimensional cell culture." In Technology Platforms for 3D Cell Culture, 143–72. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781118851647.ch7.
Full textCadwell, John J. S., and William G. Whitford. "Three-dimensional cell-based assays in hollow fibre bioreactors." In Technology Platforms for 3D Cell Culture, 327–50. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781118851647.ch14.
Full textMaragos, Chris M. "Novel Assays and Sensor Platforms for the Detection of Aflatoxins." In Advances in Experimental Medicine and Biology, 85–93. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0629-4_9.
Full textConference papers on the topic "Assay platform"
Sweet, Martin R., Mark M. Pickrell, Matthew R. Newell, Richard B. Williams, Robert B. Merl, Colin J. Carrol, and David G. Pelowitz. "The IAEA Universal Nondestructive Assay Data Acquisition Platform (UNAP)." In 2009 1st International Conference on Advancements in Nuclear Instrumentation, Measurement Methods and their Applications (ANIMMA). IEEE, 2009. http://dx.doi.org/10.1109/animma.2009.5503660.
Full textBian, Dakai, Jason C. Tsui, Mikhail Repin, Guy Garty, Helen Turner, Y. Lawrence Yao, and David J. Brenner. "Platform-Dependent Liquid Handling in High-Throughput Biodosimetry Tool." In ASME 2016 11th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/msec2016-8513.
Full textNwankire, Charles E., Robert Burger, Triona O'Connell, Thomas Glennon, and Jens Ducree. "Full integration of a liver assay panel on a centrifugal microfluidic platform." In 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII). IEEE, 2013. http://dx.doi.org/10.1109/transducers.2013.6626781.
Full textHong, Chin-Yih, Herng-Er Horng, Hong-Chang Yang, and Shieh-Yueh Yang. "Bio-Assays Using Bio-Functionalized Magnetic Nanoparticles." In ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-49503.
Full textShin, Dong Jin, Pornpat Athamanolap, Liben Chen, and Tza-Huei Wang. "A mobile phone-operated droplet magnetofluidic assay platform for nucleic acid amplification testing." In 2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2017. http://dx.doi.org/10.1109/nems.2017.8017071.
Full textBaldini, Francesco, Adolfo Carloni, Ambra Giannetti, Cosimo Trono, Giampiero Porro, and Lorena Tedeschi. "An optical platform based on fluorescence anisotropy for C — reactive protein assay." In 2008 IEEE Sensors. IEEE, 2008. http://dx.doi.org/10.1109/icsens.2008.4716657.
Full textChen, Fan-En, Alexander Y. Trick, Wen Hsieh, Dong Jin Shin, Liben Chen, Emily Chang, Aniruddha Kaushik, and Tza-Huei Wang. "Ratiometric Multiplexed PCR Assay on a Portable Platform for Bacterial Identification from Urine." In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE, 2019. http://dx.doi.org/10.1109/transducers.2019.8808318.
Full textCostantini, Francesca, Nicola Lovecchio, Augusto Nascetti, Giampiero de Cesare, and Domenico Caputo. "Thin Film Sensor Platform for on-Chip Detection of Fluorescence-Based Aptamer Assay." In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE, 2019. http://dx.doi.org/10.1109/transducers.2019.8808411.
Full textBooth, Ross, Seungbeom Noh, and Hanseup Kim. "A high-throughput permeability assay platform for shear stress characterization of endothelial cells." In 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2014. http://dx.doi.org/10.1109/memsys.2014.6765619.
Full textTang, Anson H. L., Antony C. S. Chan, P. Yeung, Barbara P. Chan, Edmund Y. Lam, Kenneth K. Y. Wong, and Kevin K. Tsia. "High-throughput time-stretch imaging cellular assay based on a high-speed spinning platform." In 2016 IEEE Photonics Conference (IPC). IEEE, 2016. http://dx.doi.org/10.1109/ipcon.2016.7831140.
Full textReports on the topic "Assay platform"
Report on Grouped Peer Review of Scholarly Journals in History, Philosophy and Politics. Academy of Science of South Africa (ASSAf), 2021. http://dx.doi.org/10.17159/assaf.2021/0071.
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