Relevant bibliographies by topics / ASM dysfunction

Academic literature on the topic 'ASM dysfunction'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'ASM dysfunction.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "ASM dysfunction"

1

Khan, Shah Dupesh, and N. Pandiyan. "Ejaculatory Dysfunction—A Mini Review." Advances in Sexual Medicine 05, no. 02 (2015): 39–42. http://dx.doi.org/10.4236/asm.2015.52005.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

El-Tahlawi, Samar, Noha Ezzat Mohammad, Asmaa Younes Elsary, Noha Mohamed Yousef, and Talal Abdelreheem. "Female Sexual Dysfunction in Elfayoum Governorate." Advances in Sexual Medicine 08, no. 01 (2018): 1–13. http://dx.doi.org/10.4236/asm.2018.81001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Jesudason, E. C., N. P. Smith, M. G. Connell, D. G. Spiller, M. R. H. White, D. G. Fernig, and P. D. Losty. "Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth." American Journal of Physiology-Lung Cellular and Molecular Physiology 291, no. 4 (October 2006): L559—L565. http://dx.doi.org/10.1152/ajplung.00498.2005.

Full text
Abstract:
Prenatal airway smooth muscle (ASM) peristalsis appears coupled to lung growth. Moreover, ASM progenitors produce fibroblast growth factor-10 (FGF-10) for lung morphogenesis. Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia, FGF-10 deficiency, and postnatal ASM dysfunction. We hypothesized ASM dysfunction emerges in tandem with, and may contribute toward, the primordial lung hypoplasia that precedes experimental CDH. Spatial origin and frequency of ASM peristaltic waves were measured in normal and hypoplastic rat lungs cultured from day 13.5 of gestation (lung hypoplasia was generated by nitrofen dosing of pregnant dams). Longitudinal lung growth was assayed by bud counts and tracing photomicrographs of cultures. Coupling of lung growth and peristalsis was tested by stimulation studies using serum, FGF-10, or nicotine and inhibition studies with nifedipine or U0126 (MEK1/2 inhibitor). In normal lung, ASM peristalsis is developmentally regulated: proximal ASM becomes quiescent (while retaining capacity for cholinergic-stimulated peristalsis). However, in hypoplastic lung, spontaneous proximal ASM activity persists. FGF-10 corrects this aberrant ASM activity in tandem with improved growth. Stimulation and inhibition studies showed that, unlike normal lung, changes in growth or peristalsis are not consistently accompanied by parallel modulation of the other. ASM peristalsis undergoes FGF-10-regulated spatiotemporal development coupled to lung growth: this process is disrupted early in lung hypoplasia. ASM dysfunction emerges in tandem with and may therefore contribute toward lung hypoplasia in CDH.
APA, Harvard, Vancouver, ISO, and other styles
4

Alidu, Huseini, W. K. B. A. Owiredu, Nafiu Amidu, Peter Paul Mwinsanga Dapare, Ahmed Tijani Bawah, Christian Kofi Gyasi-Sarpong, and Christian Obirikorang. "The Metabolic Syndrome and Sexual Dysfunction in a State of Inflammation." Advances in Sexual Medicine 07, no. 02 (2017): 82–96. http://dx.doi.org/10.4236/asm.2017.72006.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Dumbraveanu, Ion, Iurie Arian, Andrei Munteanu, Daniela Catereniuc, and Adrian Tanase. "Erectile Dysfunction in Male with Glans Penis Apocrine Hydrocystoma: Organic or Psychogenic?" Advances in Sexual Medicine 07, no. 03 (2017): 131–38. http://dx.doi.org/10.4236/asm.2017.73010.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Eyada, Moustafa M. K., Alaa-Aldin S. Abd-Elhamid, Riham A. F. Elboghdady, Ahmed M. Gadallah, and Mohamed Azab. "Assessment of Female Sexual Dysfunction in Patients with Premenopausal Female Pattern Hair Loss." Advances in Sexual Medicine 10, no. 03 (2020): 86–103. http://dx.doi.org/10.4236/asm.2020.103006.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Keeler, Allison M., Donghai Liu, Marina Zieger, Lang Xiong, Jeffrey Salemi, Karl Bellvé, Barry J. Byrne, David D. Fuller, Ronghua ZhuGe, and Mai K. ElMallah. "Airway smooth muscle dysfunction in Pompe (Gaa−/−) mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 312, no. 6 (June 1, 2017): L873—L881. http://dx.doi.org/10.1152/ajplung.00568.2016.

Full text
Abstract:
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA), an enzyme responsible for hydrolyzing lysosomal glycogen. Deficiency of GAA leads to systemic glycogen accumulation in the lysosomes of skeletal muscle, motor neurons, and smooth muscle. Skeletal muscle and motor neuron pathology are known to contribute to respiratory insufficiency in Pompe disease, but the role of airway pathology has not been evaluated. Here we propose that GAA enzyme deficiency disrupts the function of the trachea and bronchi and this lower airway pathology contributes to respiratory insufficiency in Pompe disease. Using an established mouse model of Pompe disease, the Gaa−/− mouse, we compared histology, pulmonary mechanics, airway smooth muscle (ASM) function, and calcium signaling between Gaa−/− and age-matched wild-type (WT) mice. Lysosomal glycogen accumulation was observed in the smooth muscle of both the bronchi and the trachea in Gaa−/− but not WT mice. Furthermore, Gaa−/− mice had hyporesponsive airway resistance and bronchial ring contraction to the bronchoconstrictive agents methacholine (MCh) and potassium chloride (KCl) and to a bronchodilator (albuterol). Finally, calcium signaling during bronchiolar smooth muscle contraction was impaired in Gaa−/− mice indicating impaired extracellular calcium influx. We conclude that GAA enzyme deficiency leads to glycogen accumulation in the trachea and bronchi and impairs the ability of lower ASM to regulate calcium and respond appropriately to bronchodilator or constrictors. Accordingly, ASM dysfunction may contribute to respiratory impairments in Pompe disease.
APA, Harvard, Vancouver, ISO, and other styles
8

Rodríguez-Sureda, Víctor, Francesca Crovetto, Stefania Triunfo, Olga Sánchez, Fátima Crispi, Elisa Llurba, Eduard Gratacós, Francesc Figueras, and Carmen Domínguez. "Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study." Biological Chemistry 397, no. 3 (March 1, 2016): 269–79. http://dx.doi.org/10.1515/hsz-2015-0266.

Full text
Abstract:
Abstract The pathogenic basis of abnormal placentation and dysfunction in preeclampsia (PE) is highly complex and incompletely understood. Secretory sphyngomyelinase activity (S-ASM) was analyzed in plasma samples from 158 pregnant women developing PE and 112 healthy pregnant controls. Serum PlGF, sFlt-1, s-Endoglin and sVCAM were measured. Results showed S-ASM activity to be higher in women who later developed PE than in those with uncomplicated pregnancies (40.6% and 28.8% higher in the late- and early-onset groups, respectively). Plasma S-ASM activity correlated significantly with circulating markers of endothelial damage in the late-PE group (endoglin and sVCAM-1), with plasma cholesterol and total lipid levels. However, these significant associations were not observed in the early-PE or control groups. This work provides the first evidence of significantly elevated circulating S-ASM activity in the first trimester of pregnancy in women who go on to develop PE; thus, it may be deduced that the circulating form of ASM is biologically active in PE and could contribute to promoting endothelial dysfunction and cardiovascular programming. Plasma S-ASM measurement may have clinical relevance as a further potential biomarker contributing to the earliest identification of women at risk of developing preeclampsia.
APA, Harvard, Vancouver, ISO, and other styles
9

Nkumu, Matthieu Marc Loposso, Christian Kane Kapinga, Mafuta Tsita Alpha, Dieu Donné Moningo Molamba, Nkodila Aliosha, Augustin Punga Maole Monga-Lembe, Jean Paul Esika Mokumo, Diangienda Nkutima Pablo, Mujinga Lukusa Elisabeth, and Dirk De Ridder. "A Cross-Sectional Study According to Risk Factors Associated with Erectile Dysfunction in Men." Advances in Sexual Medicine 10, no. 03 (2020): 104–18. http://dx.doi.org/10.4236/asm.2020.103007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Bao, Jun-Xiang, Min Xia, Justin L. Poklis, Wei-Qing Han, Christopher Brimson, and Pin-Lan Li. "Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries." American Journal of Physiology-Heart and Circulatory Physiology 298, no. 3 (March 2010): H992—H1002. http://dx.doi.org/10.1152/ajpheart.00958.2009.

Full text
Abstract:
The present study determined whether activation of acid sphingomyelinase (ASM) drives membrane proximal lysosomes to fuse to the cell surface, facilitating membrane lipid rafts (LRs) clustering in coronary arterial endothelial cells (CAECs) and leading to endothelial dysfunction. By confocal microscopy, the activators of ASM, phosphatidylinositol (PI), and bis (monoacylglyceryl) phosphate (Bis), and an inducer of ASM, butyrate, were found to increase LRs clustering in bovine CAECs, which was blocked by lysosome fusion inhibitor vacuolin-1. However, arsenic trioxide (Ars), an inducer of de novo synthesis of ceramide, had no such effect. Similarly, vacuolin-1-blockable effects were observed using fluorescence resonance energy transfer detection. Liquid chromatography-electrospray ionization-tandem mass spectrometry analysis demonstrated that all of these treatments, even Ars, increased ceramide production in CAECs. When ASM gene was silenced, all treatments except Ars no longer increased ceramide levels. Furthermore, dynamic fluorescence monitoring in live cells showed that PI and Bis stimulated lysosome-membrane fusion in CAECs. Functionally, PI and Bis impaired endothelium-dependent vasodilation in perfused coronary arteries, which was blocked by vacuolin-1 and a lysosome function inhibitor, bafilomycine. FasL (Fas ligand), a previously confirmed lysosome fusion stimulator as a comparison, also produced a similar effect. It is concluded that ASM activation serves as a triggering mechanism and driving force, leading to fusion of membrane proximal lysosomes into LR clusters on the cell membrane of CAECs, which represents a novel mechanism mediating endothelial dysfunction during death receptor activation or other pathological situation.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "ASM dysfunction"

1

Burnett, Hollie. "Executive dysfunction in high functioning autism." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25825.

Full text
Abstract:
Background: There is presently a lack of consistency in research designed to measure executive functioning (EF) in autism that may be attributable to lack of homogeneity or comorbid conditions (i.e. learning disability or additional diagnosis) in test samples. Aim: A systematic review focused on a subset of EF (verbal fluency: VF) was conducted, using only studies of high-functioning individuals with autism (HFA) without an additional diagnosis or learning disability. An empirical study was conducted comparing the executive functioning profile of individuals with HFA and typically developed (TD) individuals. Method: For the systematic review, 16 studies met the specified inclusion criteria, depicting 15 semantic (category), 14 phonological (letter), and 6 switching (categories) VF tasks. In order to assess potential bias, the available VF information of the included papers was scrutinised by the author and an independent clinical practitioner. For the empirical paper, 22 HFA and 22 TD participants (mean age = 28, range = 17-73, 52% male) without a comorbid condition, learning disability or brain injury completed three subtests from the WAIS-IV (vocabulary, block design and digit span) and all subtests of the Delis–Kaplan Executive Functioning System (D-KEFS). Results: For the systematic review, a minority of semantic and phonological VF studies reported a significant difference between typically developed and HFA populations. Five of the six semantic switching studies reported a significant difference between groups. All papers included were of good or adequate quality and inter-rater reliability was high. For the empirical paper, the HFA group performed significantly poorer on the switching condition of the design fluency task, semantic conditions of the verbal fluency task and on the word context task overall. No other significant differences were observed. Summary: Although the systematic review concluded that there was insufficient evidence to support that disfluency can be attributed to autistic symptomology, the empirical study found that the HFA group performed poorer than TD in semantic VF and other subtests designed to measure generating novel ‘imaginative’ ideas, without visual cues to aid performance. The deficit on these subtests was increased when there was the added condition requiring the participant to switch between newly formed concepts. Conclusions: Although in VF, results are mixed, the empirical study demonstrates that even in a group of high-functioning individuals there are still measurable differences in EF between TD and HFA samples that may not be apparent through more general cognitive testing. Implications for using a neuropsychological profile for adults with HFA are discussed.
APA, Harvard, Vancouver, ISO, and other styles
2

David, Dylan Naitraj. "Inflammation-Induced HSPC Dysfunction: Towards a Better Understanding of the Role of MAVS, ASC, and Caspase-1 in HSPC Dysfunction and Bone Marrow Failure." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1626356668978688.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Sarn, Nicholas Brian. "MICROGLIA PATHOLOGY: AN INHERENT FEATURE OF CONSTITUTIONAL PTEN DYSFUNCTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619526347351812.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Pitzer, Ashley. "Contribution of ASC-Inflammasome to Vascular Endothelial Dysfunction: Role of RNA Receptor RIG-I." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5050.

Full text
Abstract:
Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase and recently identified as a cytosolic RNA receptor in mammalian cells. The role of RIG-I in the regulation of vascular function under physiological and pathological conditions is unknown. Recent studies have shown that the inflammasome serves as a crucial initiator of cytokine-mediated inflammation mediating the pathogenesis of cardiovascular disease. The present study tested whether RIG-I activation triggers inflammasome formation and subsequent cytokine-mediated inflammation in the endothelium of mice coronary arteries. Using both genetic and pharmacological interventions of the RIG-I inflammasome, we first characterized whether specific activation of RIG-I via 3pRNA transfection induced the formation of an ASC-containing inflammasome in mouse vascular endothelial cells (MVECs). We confirmed that 3pRNA dose-dependently increased RIG-I protein levels and release of of type I IFNβ and IL-1b (a prototype cytokine from inflammasome activation), confirming RIG-I activation. We found that MVECs transfected with 3pRNA exhibited increased colocalization of RIG-I with apoptosis-associated speck-like protein (ASC) or caspase-1 and elevated active caspase-1 and IL-1β levels, indicating the formation and activation of the RIG-I inflammasome. This RIG-I inflammasome activation was accompanied by endothelial barrier dysfunction. In the presence of 3pRNA, ZO-1 and ZO-1 and VE-Cadherin expression diminished, and inhibiting caspase-1 and silencing inflammasome components attenuated this effect. To test the functional role of RIG-I and its affect on the permeability of mouse ECs, we performed a transwell permeability assay. Results confirmed that 3pRNA induced increased permeabilization of these mouse ECs, which was attenuated when inhibiting and silencing inflammasome components. These data indicate that increased expression and activity of RIG-I activate IL-1b producing inflammasomes in ECs, which may represent an early molecular mechanism mediating vascular inflammation and endothelial dysfunction independent of Nlrp3. Furthermore, we investigated the role of anti-aging gene Klotho in the regulation of RIG-I inflammasome activation. The Klotho protein has been shown to directly interact with RIG-I in senescent cells to block RIG-I multimerization and downstream production of pro-inflammatory cytokines. Administration of D-saccharic acid 1,4-lactone (saccharolactone) in vitro, a pharmacological inhibitor of Klotho activity, substantially increased inflammasome activation. In addition, mice injected with saccharolactone exhibited increased RIG-I inflammasome formation and activation within the coronary artery endothelium. These results suggest that decreased Klotho activity may activate RIG-I and thereby increase inflammasome activity. Therefore, the present study defines a novel role for RIG-I inflammasome activation in vascular dysfunction.
APA, Harvard, Vancouver, ISO, and other styles
5

Hsin-Chin, Chen, and 陳信誌. "Clinical Assessment of Hand Writing , Shoulder/Elbow Motor Control Function for Upper Motor Neuron Dysfunction Patients and Development of a Rehabilitation Robotic Arm for Upper Extremity Motor Learning." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/69320938591967511117.

Full text
Abstract:
碩士
長庚大學
機械工程研究所
90
Patients with writer’s cramp or upper motorneuron disease (ex. Parkinson’s disease, stroke, and other brain injuries) often have difficulty in processing upper arm movement because of involuntary muscle contraction or neuron regression. This often results in trembling of the involved extremity. Most patients , still experience palm/arm movement obstacles even after treatment/surgery. Therefore, clinical evaluation and rehabilitation training for writing with a pen and arm movement are important parts of the postoperative management.. In this research , clinical testing and quantitative evaluation of the writing function of the patients was done. A series of robotic manipulators for arm movement assessment and rehabilitation was designed and its applications were tested quantitatively and diagrammatically. In the first part of this research , an evaluation system was developed which aimed to quantitatively measure the patients’ arm function using four parameters : the contact pressure between paper and pen, the time delay before start of writing, the hesitation time spent between words, and the total written words in a given time. An evaluation standard for quantitative writing was set-up, clinical testing and subsequent statistical analysis of the results was done. A total of 26 patients and 13 control subjects were studied. The results were analyzed using the SPSS statistical software and showed that t test values of the four estimation parameters were all less than 0.05. This means that there was a significant difference between the evaluation parameters of the patients and normal control subjects. These results can provide a reference for clinicians when diagnosing patients. The second part of the research was aimed to decrease the time and energy spent by therapists who usually have to repeatedly say or demonstrate the correct motions for arm rehabilitation. A mechanical device was designed to manipulate the arm movement and provide the patient with a continuous passive rehabilitation. The machine used was a SCARA type robotic manipulator with four degrees of freedom. This was connected to a computer with a software based on Windows 2000 and Visual Basic 6.0. Also designed for this project to adjust the rehabilitation parameters (i.e. velocity, circle/ellipse movement locus size, etc.). This set up enables the doctor or therapist to choose the proper rehabilitation parameters and patterns for patients who will undergo a continuous upper arm continuous passive rehabilitation. The third part of the research was aimed to consolidate the mechanical 3-D Digitizer already existing in the market and the interface software we developed into a manipulator for the evaluation of upper arm movement function in order to improve the defects noted during initial rehabilitation. This would also provide diagrammatic (arm movement locus radial error, distribution diagram) and quantitative (radial error of normal value, radial error of absolute value, average drawing circle rate, etc.) evaluation indicators and clinical test standards. This consolidated robotic manipulator was further tested on 11 stroke paralysis patients, 5 normal elders, and 6 normal youths. The results showed that there was a significant difference between the three test groups. From the quantitative evaluation indicators, it is shown that the radial error of absolute value was 2 to 3 times more among the stroke patients compared to that of the normal elders, and 3 to 4 times more compared to that of the normal youths. From the diagrammatic evaluation indicators, we found that in the arm movement locus radial error distribution diagram, stroke paralysis patient had the widest area of radial error of absolute value compared to the rest. The error value was about 4 to 9 times more than the normal elder group and 9 to 16 times more than the normal youth group. This objectively result shows that the stroke patients had more serious functional defects. These results can provide a reference for clinicians in the diagnosis of functional defects of patients. The hand writing function evaluation system for using a pen and the manipulator for the assessment of arm function will be able to provide assistance to the clinician as new tools to evaluate patients’ palm/arm motor function. The robotic manipulator can be used for the postoperative rehabilitation the training of the patient. The standards and quantitative evaluation indicators developed in this research can be used as new tool and methods of the treatment for upper motorneuron or palm/arm movement dysfunction patients.
APA, Harvard, Vancouver, ISO, and other styles
6

Rahn, Ingmar. "Neurohumorale Aktivierung in einem kardiovaskulären Risikokollektiv - Einfluss von diastolischer oder systolischer Dysfunktion." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B173-D.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Laranjo, Mariana Barradas Serrano. "The role of GPRASP2 on mGluR5 signalling." Master's thesis, 2018. http://hdl.handle.net/10316/86125.

Full text
Abstract:
Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia
A perturbação do espectro do autismo (PEA) inclui um grupo heterogéneo de condições de neurodesenvolvimento, caracterizadas por défices na linguagem, alterações na interação social e na comunicação e por comportamentos repetitivos e estereotipados. Estudo epidemiológicos estimam que mais de 1% da população mundial tem uma PEA e que, 70% dos indivíduos com PEA também apresentam défice intelectual (DI).Há duas teorias para explicar a patofisiologia das PEA: uma destas teorias considera que é a perda da homeostasia neuronal, devido à disfunção sináptica e ao desequilíbrio entre a excitação e inibição que desencadeia as comorbidades características das PEAs. A outra teoria admite que são as alterações de circuitos neuronais específicos (conetividade neuronal) que desencadeiam as PEAs. Contudo, o exato mecanismo que desencadeia as PEAs não está totalmente definido. Estudo epidemiológicos sugerem uma forte componente genética nesta desordem. Para além disto, estudos genéticos têm identificado proteínas envolvidas na função sináptica com implciações nas PAE.Os recetores acoplados às proteínas G (GPCRs) desempenham várias funções na regulação da sinalização sináptica. Assim, as proteínas que interagem ou regulam estes recetores, permitindo a sua modulação, poderão emergir como possíveis genes associados a PAE. Um exemplo de uma proteína que poderá interagir e/ou modular os GPCRs é a GPRASP2, tendo já sido associada a desordens neuropsiquiátricas, incluindo PAE. A GPRASP2 regula a sinalização das GPCR, incluindo dos recetores metabotrópicos de glutamato (mGLuRs), que estão igualmente associados a PEA e DI.De forma a perceber o papel da GPRASP2 no sistema nervoso, um modelo de murganhos knockout (KO) para o gene Gprasp2 foi desenvolvido. Este modelo apresenta diferentes fenótipos associados aos PEA, incluindo alterações no comportamento social. A GPRASP2 é expressa em diferentes regiões do cérebro, como no hipocampo, tálamo e hipotálamo. Para além disto, alterações na expressão dos níveis de GPRASP2 afetam a morfologias as espiculas dendríticas, a complexidade neuronal e o tráfico dos mGluRs, em culturas do hipocampo. Contudo, a função sináptica desta proteína e o seu papel na modulação da sinalização dos GPCR continua por concluir.De forma a entender a função da GPRASP2 nos recetores mGluR5s, recorreu-se a culturas organotáticas do hipocampo incubadas na presença e ausência de DHPG de forma a estudar as vias de sinalização ERK, PI3K e mTOR utilizando a técnica de western blot. Foram também averiguadas as alterações em proteínas sinápticas associadas à deleção do gene Gprasp2. Paralelamente, animais Gprasp2-/y e Gprasp2+/y foram sujeitos a tarefas de comportamento dependentes do hipocampo. De forma a estudar possíveis alterações na comunicação neonatal destes animais, as vocalizações foram detetadas em animais nas primeiras duas semanas de vida. Estas tarefas tiveram como objetivos analisar a função da GPRASP2 na sinapse e os efeitos da deleção deste gene no hipocampo.
Autism spectrum disorder (ASD) comprises a group of heterogeneous neurodevelopmental conditions, characterised by deficits in language, impairments in social interaction and communication and restricted interests and repetitive or stereotyped behaviours. Epidemiological studies estimate that more than 1% of the world’s human population has an ASD and that more than 70% of those with autism also have intellectual disability. There are two main theories to explain the pathophysiology of ASD: one involves failure in maintaining neural homoeostasis (synaptic dysfunction and E/I imbalance) and another involves alterations in specific neural circuits (cerebral connectivity). However, the exact mechanism that triggers an ASD is not yet fully understood.Twin and epidemiological studies strongly suggest that genetic factors play an important role in this disease. Moreover, genetic studies have now identified several proteins involved in synaptic function as strongly implicated in ASD.G-protein coupled receptors (GPCRs) have a role in the regulation of synaptic signalling. As such, GPCRs partners that modulate these receptors might be candidate genes for ASD. One example is the family of G-protein coupled receptor associated sorting proteins (GPRASP). GPRASP2, in particular, has been implicated in neuropsychiatric disorders, including ASD. GPRASP2 regulates GPCRs signalling, including metabotropic glutamate receptor (mGluR), themselves associated with ASD and ID pathophysiology. To understand the role of GPRASP2 in the nervous system, a new knockout (KO) mouse model was generated, and several autistic phenotypes, including abnormal social behaviour, were identified in this animal model. GPRASP2 is expressed in several brain regions, such as the hippocampus, thalamus, and hypothalamus. Additionally, changes in the expression levels of GPRASP2 can affect dendritic spine morphology, neuronal complexity and mGluR5 trafficking in rat hippocampal neuronal cultures. However, the synaptic function of GPRASP2 and its role in modulating GPCR signalling remains largely unknown.To elucidate the role of GPRASP2 upon mGluR5, hippocampal organotypic slices were incubated in the presence/absence of DHPG and downstream signalling was analysed using western blot techniques to study ERK, PI3K and mTOR pathways. We also assessed alterations in synaptic protein when GPRASP2 is ablated in vivo. Additionally, we performed hippocampal-dependent tasks and measured ultrasonic vocalisations in GPRASP2 knockout mice to complement the characterisation of this line as a model for ASD. These tasks were performed to understand the role of GPRASP2 in the synapse function and to dissect the downstream effects of its deletion.
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "ASM dysfunction"

1

Manfredi, Claudia, ed. Models and Analysis of Vocal Emissions for Biomedical Applications. Florence: Firenze University Press, 2013. http://dx.doi.org/10.36253/978-88-6655-470-7.

Full text
Abstract:
The MAVEBA Workshop proceedings, held on a biannual basis, collect the scientific papers presented both as oral and poster contributions, during the conference. The main subjects are: development of theoretical and mechanical models as an aid to the study of main phonatory dysfunctions, as well as the biomedical engineering methods for the analysis of voice signals and images, as a support to clinical diagnosis and classification of vocal pathologies.
APA, Harvard, Vancouver, ISO, and other styles
2

Manfredi, Claudia, ed. Models and Analysis of Vocal Emissions for Biomedical Applications. Florence: Firenze University Press, 2009. http://dx.doi.org/10.36253/978-88-6453-096-3.

Full text
Abstract:
The MAVEBA Workshop proceedings, held on a biannual basis, collect the scientific papers presented both as oral and poster contributions, during the conference. The main subjects are: development of theoretical and mechanical models as an aid to the study of main phonatory dysfunctions, as well as the biomedical engineering methods for the analysis of voice signals and images, as a support to clinical diagnosis and classification of vocal pathologies.
APA, Harvard, Vancouver, ISO, and other styles
3

McCarthy, Barry, and Lana M. Wald. Sexual Dysfunction and Couple Dysfunction. Edited by Erika Lawrence and Kieran T. Sullivan. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199783267.013.006.

Full text
Abstract:
Couple sex therapy is best understood as a subspecialty of couple therapy. Couple sex therapy may focus on problems in desire, pleasure, eroticism, and/or satisfaction. Although arousal and orgasm problems need to be carefully assessed and treated, problems related to desire represent the primary concern that brings couples to sex therapy. There is a great need for more research on sex therapy models, therapeutic processes, and outcome. The authors describe in detail the psychobiosocial model of assessment, treatment, and relapse prevention. A particularly important component is the four-session assessment, which features individual psychological, relational, and sexual histories. This comprehensive, multidimensional treatment model focuses on the use of psychosexual skill exercises practiced at home by the couple. Therapy interventions are directed at factors that subvert sexual desire and function as well as interventions to promote desire, pleasure, eroticism, and satisfaction. Clients are urged to develop a couple sexual style that balances each person’s sexual voice, thus becoming an intimate sexual team. The goal for all couples, straight or gay, married or unmarried, is to integrate intimacy and eroticism into their relationship. An individualized relapse prevention plan is also discussed as an integral component of comprehensive couple sex therapy.
APA, Harvard, Vancouver, ISO, and other styles
4

de Bie, Robertus M. A., and Susanne E. M. Ten Holter. “My Arm Is Not Working”. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190607555.003.0011.

Full text
Abstract:
Corticobasal syndrome is a clinical diagnosis based on the presence of one or more movement disorders suggestive of basal ganglia dysfunction, typically asymmetrical, with evidence of associated cortical dysfunction. This is a pathologically heterogeneous group of disorders that can share a common phenotype. Corticobasal degeneration is one of these pathologies, representing one of the rarest forms of atypical parkinsonism. When confronted with a patient with higher cortical dysfunction, specific assessment for apraxia, cortical sensory loss, and cognition is indicated. Corticobasal syndrome is currently untreatable, regardless of the nature of the underlying pathology, and in most cases progression is fast with significant disability that is typically unresponsive to levodopa.
APA, Harvard, Vancouver, ISO, and other styles
5

Feldman, Jamie, and Karin Larsen. Sexual Dysfunction. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.032.

Full text
Abstract:
Sexual dysfunction covers a range of disturbances in sexual response affecting desire, arousal, and orgasm or involving pain with sexual activity. Depression and sexual dysfunction have long been known as comorbid conditions; however, some research suggests that depressed mood may not always be associated with specific sexual dysfunctions. Associations between sexual dysfunction and depression appears bidirectional, such that either one of these conditions may trigger or worsen the other, while improvement in one may also improve the other. This chapter examines the complex relationship between depression and male and female sexual dysfunctions. We explore the classification and prevalence of sexual dysfunction, the known interconnections involving neurobiology, and psychological issues. Finally, we summarize the core principles of evaluation and treatment of common sexual dysfunctions, particularly in the context of depressive illness.
APA, Harvard, Vancouver, ISO, and other styles
6

Porst, Hartmut. Erectile dysfunction. Edited by David John Ralph. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0103.

Full text
Abstract:
Erectile dysfunction (ED) can be improved by changing certain lifestyle factors such as sedentary lifestyle, unhealthy food, nicotine and alcohol abuse, or optimal management of risk factors/concomitant diseases causing or aggravating ED such as dyslipidaemia, hypertension, diabetes mellitus, depression, BPH/LUTS, or hypogonadism.First choice in the medical therapy of ED are PDE-5 inhibitors such as sildenafil, vardenafil, and tadalafil used p.r.n, or on a daily low-dose regimen regarding tadalafil, especially in patients suffering from ED and BPH/LUTS. Yohimbine and L-arginine may be considered in patients with mild PE, which also applies for topical alprostadil. Both transurethral alprostadil and self-injection therapy with alprostadil, papaverine/phentolamine, or the trimix combination consisting of all three compounds is mostly reserved for those patients non-or poorly responding to PDE-5 inhibitors. Finally, combination therapy with PDE-5 inhibitors and transurethral alprostadil or intracavernous self-injection therapy can be able to rescue non-responders to either monotherapy.
APA, Harvard, Vancouver, ISO, and other styles
7

Saccà, Antonino, and Andrea Salonia. Erectile dysfunction. Edited by David John Ralph. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0102.

Full text
Abstract:
Erectile dysfunction (ED) has progressively emerged as an important sentinel marker of cardiovascular and overall health among men. A timely and accurate diagnosis of ED may thus represent a significant opportunity not only to diagnose the dysfunction per se, but also to comprehensively identify co-morbid and potentially life-threatening conditions. Basic work-up for a man seeking help for ED should start considering that ED may share several modifiable and unmodifiable common risk factors with cardiovascular disorders and other potential life-threatening conditions. Overall, most patients with ED can be adequately managed with a basic diagnostic work-up; this includes a comprehensive medical and sexual history, along with a physical examination and some laboratory tests. Conversely, only some selected patients may also need specific diagnostic tests.
APA, Harvard, Vancouver, ISO, and other styles
8

Chong, Ji Y., and Michael P. Lerario. Progressive Gait Dysfunction. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190495541.003.0034.

Full text
Abstract:
Spinal vascular malformations are rare, with dural arteriovenous fistulas (AVFs) accounting for the majority of the pathology. Unlike spinal arteriovenous malformations, which cause abrupt neurological change as a result of hemorrhage, spinal dural AVFs tend to result in a progressive myelopathy through venous congestion and cord edema. If diagnosed and treated early with endovascular embolization or microsurgery, some deficits may be reversible.
APA, Harvard, Vancouver, ISO, and other styles
9

Foorsov, Victor, Omar Dyara, Robert Bolash, and Bruce Vrooman. Sacroiliac Joint Dysfunction. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0019.

Full text
Abstract:
Sacroiliac joint dysfunction is a common cause of chronic low back pain. Certain populations are particularly susceptible to disorders of this unique joint. Anatomically, the joint is complex, and the clinician must understand both intrinsic and extrinsic structures in its vicinity. Unfortunately, there are no particular pathognomonic findings on radiologic imaging. A cluster of physical examination findings has been recognized as demonstrating sacroiliac joint pain. Various treatment options exist in the evidence-based treatment of this condition.
APA, Harvard, Vancouver, ISO, and other styles
10

Amin, Sandeep. Cervical Facet Dysfunction. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0005.

Full text
Abstract:
Cervical facet dysfunction poses a diagnostic and therapeutic dilemma in patients with axial neck pain due to either degenerative changes or whiplash injuries as it presents with a paucity of diagnostic radiologic or examination findings. The specific orientation of the cervical facet joints renders them particularly vulnerable to whiplash injury. This chapter examines the clinically relevant anatomy with nuances unique to the cervical spine, etiology of the structural changes, diagnostic tools, and treatment of cervical facet dysfunction. Understanding the relevant anatomy and referral patterns of cervical facet joints allows for more targeted diagnosis and treatment. There are strong evidence-based options in the treatment of cervical facet joint dysfunction.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "ASM dysfunction"

1

Zaragoza, Briana, and T. Gonzalez. "Discrimination as dysfunction." In Libraries as Dysfunctional Organizations and Workplaces, 109–31. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Hoover, Jasmine. "Dysfunction by (dis)organization." In Libraries as Dysfunctional Organizations and Workplaces, 283–91. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Doran-Myers, Miranda, and Crystal Schimpf. "Workplace dysfunction and intellectual freedom in public libraries." In Libraries as Dysfunctional Organizations and Workplaces, 132–48. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Acadia, Spencer, and Kyndal Vogt. "An introduction to dysfunction in the library workplace." In Libraries as Dysfunctional Organizations and Workplaces, 1–50. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Gamache, Éthel, and Spencer Acadia. "You are seen." In Libraries as Dysfunctional Organizations and Workplaces, 193–210. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Lopez, Erica. "Improving dysfunctional recruitment and retention in academic libraries by honoring the whole person." In Libraries as Dysfunctional Organizations and Workplaces, 72–94. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Foster Kaufman, Amanda, Amy F. Fyn, Millicent Weber, and Christina Heady. "The dysfunctional library and academic librarian turnover." In Libraries as Dysfunctional Organizations and Workplaces, 51–71. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Geary, Carol Anne, and Spencer Acadia. "A descriptive study of workplace bullying in U.S. libraries during the COVID-19 pandemic." In Libraries as Dysfunctional Organizations and Workplaces, 211–39. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sasyk, Zorian M. "Work alienation in academic libraries." In Libraries as Dysfunctional Organizations and Workplaces, 240–53. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Vong, Silvia. "Bamboo ceiling reframed." In Libraries as Dysfunctional Organizations and Workplaces, 254–68. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003159155-12.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "ASM dysfunction"

1

Hald, Eric S., Zaw Win, Marianne R. Scheitel, and Patrick W. Alford. "High-Throughput Microtissue Contractility Assay for In Vitro Analysis of Vascular Mechanics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14604.

Full text
Abstract:
Vascular smooth muscle (VSM) plays a key role in regulation of vascular mechanics through modulation of contractile tone. Studies suggest that mechanical or biochemical perturbation can lead to dysfunctional VSM behavior [1, 2]. This aberrant contractility may play a role in vascular dysfunction ranging from cerebral vasospasm to aneurysm genesis.
APA, Harvard, Vancouver, ISO, and other styles
2

Bell, E. David, and Samir N. Ghadiali. "Finite Element Analysis of Clinical Pressure-Flow Waveforms in a Collapsed Respiratory Airway." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175329.

Full text
Abstract:
Otitis media (OM) is the most commonly diagnosed disorder in young children and cost the US economy ∼$5 billion dollars annually[1]. Although the primary etiology responsible for the persistence of OM conditions is a dysfunctional Eustachian tube (ET), the biomechanical mechanisms responsible for ET dysfunction are not well established. The ET is a collapsible, respiratory airway which connects the nasopharynx with the middle ear (ME). The ET normally exists in a closed state and must be periodically opened in order to clear ME fluids and ventilate the ME. The inability to open the ET results in painful sub-ambient ME pressures, fluid accumulation in the ME and the inflammation of the ME mucosa (i.e. OM).
APA, Harvard, Vancouver, ISO, and other styles
3

Otis, James C., Sharon M. Kenneally, Matthew L. Hansen, and Jonathan T. Deland. "A Cadaveric Foot Model for Posterior Tibial Tendon Dysfunction." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0109.

Full text
Abstract:
Abstract Posterior tibial tendon dysfunction (PTTD) is a significant foot disorder in which the posterior tibial tendon becomes inflamed and painful and loses its integrity. As a result, the posterior tibialis muscle/tendon unit becomes dysfunctional and, over the long term, the foot acquires a flatfoot deformity. Ideally, one would like to treat the problem early on and prevent the deformity from occurring. However, treatment to restore muscle balance in the foot in the early stages of the disorder have met with minimal success with patients eventually requiring fusions to treat the deformity and relieve pain. Currently no adequate models exist for studying the efficacy of treatment. A cadaveric foot model has been developed which simulates the muscle imbalance. The model can be used to investigate the biomechanical efficacy of surgical treatments used in early stage disease, prior to the occurrence of deformity. The model utilizes medial arch strain and talonavicular joint rotation as outcome measures.
APA, Harvard, Vancouver, ISO, and other styles
4

Stewart, Kelley C., Rahul Kumar, John J. Charonko, Pavlos P. Vlachos, and William C. Little. "A Hydrodynamic Efficiency Parameter as a Novel Left Ventricular Diastolic Dysfunction Diagnostic Metric." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192954.

Full text
Abstract:
Numerous studies have shown that cardiac diastolic dysfunction and diastolic filling play a critical role in dictating overall cardiac health and demonstrated that the filling wave propagation speed is a significant index of the severity of diastolic dysfunction [1, 2]. However, the governing flow physics underlying the relationship between propagation speed and diastolic dysfunction are poorly understood. More importantly, currently there is no reliable metric to allow clinicians the ability to diagnose cardiac dysfunction on the basis of the wave filling speed.
APA, Harvard, Vancouver, ISO, and other styles
5

Kilu, Rufai, Mohammed-Aminu Sanda, Lilian Ama Afun, and Anna Alacovska. "The dysfunctional systems of creative entrepreneurship in Ghana." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002157.

Full text
Abstract:
This paper aim at generating knowledge on creative industries in a Ghanaian context, which drive understanding of creative entrepreneurship forward and shape theorization on dysfunctional systems of the creative entrepreneurship. Ghana’s Creative Arts Industry is perhaps the oldest industry: our forefathers danced, had theatre, played music, made amazing crafts and artifacts and created fine garments. Ghana’s Creative Arts span from smock weaving, xylophone and calabash making centers in Savanah and Northern Ghana to kente weavers of Bonwire and Agbozome; and from wood carving at Ahwia and Aburi to the bead makers at Ada and Somanya. However, little is known about the dysfunctional systems of the creative industry in Ghana. It is against this backdrop that this study seeks to explore the dysfunctional systems of creative entrepreneurship in Ghana. An empirical research design with qualitative approach was used. Interviews, Focus Group Discussions and Workshops were used for the data collection. The results showed the creative industry is a functional engine for sustainable and inclusive economic growth, it creates decent jobs and lead to sustainable development. The results however showed a system of dysfunctions among the creative entrepreneurs in a form of government and investor support related challenges, a lack of creative capacity building and research, unfavorable policies to regulate creative activities and the lack of appreciation for Ghanaian culture. The current study generated novel empirical and theoretical knowledge on both functional and dysfunctional systems of creative entrepreneurship in Ghanaian context. It is intimated that; periods of economic challenges are characterized with creative entrepreneurship playing key survival roles. This implies industry wide partnerships is key to have a salient role in driving innovation, economic growth, and welfare, in addition to their effect on job creation. Therefore, innovative and creative entrepreneurship is considered key factor in modern Ghanaian economic development.
APA, Harvard, Vancouver, ISO, and other styles
6

Hayashi, Shigeto, Hiromichi Nakadate, Yuelin Zhang, Kojiro Mekata, Haruo Yamashita, Shinichi Nakayama, Eiji Kohmura, Yasuhiro Matsui, Hong Ji, and Shigeru Aomura. "Reproduction Analysis of Injury Condition Using Finite Element Modeling of the Head in Cases With Traumatic Higher Brain Dysfunction Caused by Traffic Accidents." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-86945.

Full text
Abstract:
Following head trauma caused by traffic accidents, many patients are unable to completely recover their social functions due to higher brain dysfunction although they are able to return home. To predict the onset and severity of post-traumatic higher brain dysfunction, the visualization of responsible injury is considered urgent. In this study, we focused on five patients with higher brain dysfunction following head trauma caused by traffic accidents to establish a method for quantitatively evaluating higher brain dysfunction. The injury conditions were reproduced on the basis of multibody dynamic and collision analyses using finite element (FE) modeling of the human head to determine mechanical responses inside the cranium of these patients. The strain on the frontal lobe generated by an injury condition was suggested to contribute to the onset of attention disturbance during the chronic phase of medical treatment. Reproduction analysis of the injury conditions using FE modeling of the head could predict the onset and severity of traumatic higher brain dysfunction.
APA, Harvard, Vancouver, ISO, and other styles
7

Sheer, Francis J., and Samir N. Ghadiali. "Parametric Analysis of Eustachian Tube Function Using Fully Coupled Fluid-Structure Interaction Models." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19425.

Full text
Abstract:
Otitis Media (OM) is the most commonly diagnosed childhood illness and has health care related cost of four billion dollars annually. [1] The onset of OM has been directly related to Eustachian Tube (ET) dysfunction. The ET has three main physiological functions, and when these functions are compromised, middle ear (ME) disorders arise. It is also known that specific populations of patients, such as those with cranio-facial abnormalities, such as a cleft palate, have a 100% onset rate of OM. Even though ET dysfunction has been related to OM, the underlying reasons for ET dysfunction in certain populations remains unknown. To gain an understanding of this system, we use fully coupled fluid-structure interaction (FSI) models of the ET based on geometries reconstructed from histological images. Using these models in systematic parameter variation studies allows us to identify which parameters of the ET can cause dysfunction. Using healthy adult subjects as a model for a well-functioning ET, we determined ET function to be sensitive to changes in TVP muscle force.
APA, Harvard, Vancouver, ISO, and other styles
8

Zakaria, Hasballah, and Johan Agathon. "Endothelial Cell Dysfunction Assessment by Arm Positioning Reactive Hyperemia Induced." In 2019 2nd International Conference on Bioinformatics, Biotechnology and Biomedical Engineering (BioMIC) - Bioinformatics and Biomedical Engineering. IEEE, 2019. http://dx.doi.org/10.1109/biomic48413.2019.9034832.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Zaylor, William, Betty Sindelar, and John R. Cotton. "Finite Element Analysis Demonstrates Splinting in the Porcine Mandibular Condyle Causes Changes in Bone Volume Fraction and Stiffness Anisotropy." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80311.

Full text
Abstract:
Currently about 10 million Americans report signs and symptoms of TMJ dysfunction. One form of treatment for TMJ dysfunction is dental splints which reorient the jaw during mastication. This presumably changes the direction, magnitude and location of mechanical loads on the mandibular condyle of the temporomandibular joint (TMJ). The precise nature of load changes and their effect on the underlying condylar trabecular bone have not been reported.
APA, Harvard, Vancouver, ISO, and other styles
10

Scott, Devon, Robin Shandas, and Wei Tan. "Effect of Vessel Stiffening and High Pulsatility Flow on Contractile Function and Proliferation of Small Arterial Cells." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19597.

Full text
Abstract:
Recent studies have identified arterial stiffening as a predictor of some vascular diseases such as pulmonary hypertension, which is characterized by dysfunction of small arteries. Stiffening is shown to cause changes in blood flow, extending high pulsatile flow into small arteries that normally experience steady flow conditions (Chui 2004). However, few studies have investigated the mechanisms underlying the effects of arterial stiffening on vascular remodeling. We hypothesized that arterial stiffness effects dysfunction of downstream vascular endothelium and smooth muscle through changes in flow pulsatility. Previously we developed a flow system to study the influence of pulse flow waves, by modulating upstream stiffness, on downstream mimetic vascular cell co-culture. With this system, the present study examines contractile and proliferating protein expressions of smooth muscle cell (SMC) co-cultured with endothelial cell (EC). The endothelium, directly interfaces with the blood flow, and transduces mechanical signals to underlying SMC (Stegemann 2005). We recently showed that high pulsatile flow induced EC dysfunction. Therefore, we further asked whether high pulsatility flow would cause characteristic changes of small arterial SMC in the hypertension condition such as smooth muscle hyperplasia (increased cell proliferation) and hypertrophy (increased contractile proteins) (Voelkel 1997), and whether these changes would be mediated by EC dysfunction.
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "ASM dysfunction"

1

Neodo, Anna, Fiona Augsburger, Jan Waskowski, Joerg C. Schefold, and Thibaud Spinetti. Monocytic HLA-DR expression and clinical outcomes in adult ICU patients with sepsis – a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0119.

Full text
Abstract:
Review question / Objective: The scope of this review was defined using PICOTS framework where 1) population: adult critically ill patients with sepsis or septic shock; 2) index prognostic factor: cell surface protein expression of mHLA-DR in blood; 3) comparative factor: none; 4) outcomes to be predicted: mortality, secondary infections, length of stay, and organ dysfunction score (sequential organ failure assessment [SOFA], multiple organ dysfunction score [MODS], logistic organ dysfunction score [LODS]), composite outcomes where component endpoints consist of at least one of the outcomes stated above (e.g., “adverse outcome” defined as death or secondary infection), 5) timing (of the prediction horizon and the moment of prognosis): any; and 6) setting: ICU. Condition being studied: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to severe infections. It can further progress to septic shock, which includes hemodynamic failure and increased mortality rates. A recent worldwide epidemiological study estimated 48.9 million sepsis cases and 11 million of sepsis-related deaths (~20% of global deaths in 2017). Although its management has advanced considerably, sepsis remains deadly and challenging to treat. The 28/30-day mortality averages around 25% for sepsis and 38% for septic shock in high-income countries. Current models describe the underlying pathophysiologic mechanisms of sepsis as an interplay between concurrent dysfunctional pro- and anti-inflammatory immune response.
APA, Harvard, Vancouver, ISO, and other styles
2

Platt, Michael L. Neural Basis of Empathy and Its Dysfunction in Autism Spectrum Disorders (ASD). Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada612863.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Platt, Michael L., and Steve W. Chang. Neural Basis of Empathy and Its Dysfunction in Autism Spectrum Disorders (ASD). Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada575868.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Platt, Michael L., Steve W. Chang, and Jean-Francois Gariepy. Neural Basis of Empathy and Its Dysfunction in Autism Spectrum Disorders (ASD). Fort Belvoir, VA: Defense Technical Information Center, August 2013. http://dx.doi.org/10.21236/ada591282.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Shi, Xiaohua, Yu Bai, and Aiguo Wang. Shaoyao Gancao Decoction for limb dysfunction after fractures around the knee: A protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0028.

Full text
Abstract:
Review question / Objective: This study aimed to evaluate the effects of SGD on patients with limb dysfunction from the perspectives of pain, limb edema, stiffness, as well as physical dysfunction. Study designs to be included: This review only includes the intervention measures of SGD, including trials comparing SGD with standard treatment and/ or placebo. Trials of SGD combined with other therapies will be included.
APA, Harvard, Vancouver, ISO, and other styles
6

CHEN, TIAN, and SONG GU. Network meta-analysis on effect of different exercise interventions on improving social dysfunction in children and adolescents with autism spectrum disorder(ASD). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0085.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Ding, Huaze, Yiling Dong, Kaiyue Zhang, Jiayu Bai, and Chenpan Xu. Comparison of dexmedetomidine versus propofol in mechanically ventilated patients with sepsis: A meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0103.

Full text
Abstract:
Review question / Objective: The aim of the present study was to evaluate the effects of dexmedetomidine compared with propofol in mechanically ventilated patients with sepsis. Condition being studied: Sepsis, which is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, contributes the highest mortality to intensive care units (ICU) worldwide . Because of the high incidence of respiratory failure in sepsis care, mechanical ventilation is always adopted to give life support and minimize lung injury . And sedation is a necessary component of sepsis care who suffers from mechanical ventilation. The Society of Critical Care Medicine suggested using either propofol or dexmedetomidine for sedation in mechanically ventilated adults. However, it remained unknown whether patients with sepsis requiring mechanical ventilation will benefit from sedation with dexmedetomidine.
APA, Harvard, Vancouver, ISO, and other styles
8

Tan, Junjie, Yanhui Chen, Jianwen Huang, and Weiguo Xu. Endovenous Ablation for the treatment of Small Saphenous Varicose Veins: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0134.

Full text
Abstract:
Review question / Objective: The aim is to summarize the results of existing studies on the endovenous ablation (EVA) for the treatment of small saphenous vein (SSV) varicose veins and to compare its role and efficacy. Condition being studied: 5% of varicose veins in the lower extremities are caused by the dysfunction of small saphenous veins (SSV). The endovenous ablation (EVA) for the treatment of SSV varices has become a trend. A study aiming to demonstrate the efficacy of a new technique in treating SSV insufficiency and varicosities is perparing to be conducted by the center where the authors of this review are affiliated with.
APA, Harvard, Vancouver, ISO, and other styles
9

Zerbib, Olivier, Yaniv Hadi, Daniel Kovarsky, Gal Sahaf Levin, Tamar Gottesman, Mor Darkhovsky, and Shaul Lev. Multiple Recurrent Pneumothoraces and Thoracic Drain Insertion in a Mechanically Ventilated Patient Suffering from Methadone Induced Cardiomyopathy. Science Repository, January 2023. http://dx.doi.org/10.31487/j.jcmcr.2022.01.02.

Full text
Abstract:
Objective: To describe the experience of a multimodal therapeutic approach in a patient with methadone-induced dilated cardiomyopathy who developed recurrent bilateral tension pneumothorax. Setting: Department of Intensive Care. Patient: A patient with methadone-induced cardiomyopathy and severe left ventricular dysfunction who after mechanical ventilation underwent bilateral tension pneumothorax and prolonged cardiovascular resuscitation (CPR). Interventions: Cardiac Angiography, Multiple counter–shock (defibrillator dose), Multiple Thoracic Drains. Case Report: A 56-year-old man with past IV drug abuse and severe left ventricular dysfunction was transferred from the intensive cardiac care unit (ICCU) to our intensive care unit (ICU) ward due to suspected aspiration pneumonia. Multiple attempts of weaning off mechanical ventilation were unsuccessful, followed by development of septic shock. Following cardiothoracic consultation, two thoracic drains were placed. Due to repeated events of bilateral tension pneumothorax and CPR attempts, a total of seven thoracic drains were placed, permitting rapid control and improvement in the patient status. The possibility of Extracorporeal Membrane Oxygenation (ECMO) was not considered as supportive care due to methadone use and severe secondary cardiomyopathy. In the following days, control and stabilization of the patient status was obtained. Vasopressor treatment withdrawal, cessation of drainage and removal of five thoracic access points were successfully performed prior to percutaneous tracheostomy. The two remaining drains were removed later on during hospitalization. After 29 days in the ICU, the patient was discharged to a step down ward.
APA, Harvard, Vancouver, ISO, and other styles
10

Zhu, Zhihong, Yue Zhuo, Haitao Jin, Boyu Wu, and Zhijie Li. Chinese Medicine Therapies for Neurogenic Bladder after Spinal Cord Injury: A protocol for systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0084.

Full text
Abstract:
Neurogenic bladder (NB), a refractory disease, is characterized by voiding dysfunction of bladder and/or urethra, and spinal cord injury (SCI) is a common cause. Chinese medicine therapies have been applied extensively in the treatment of neurogenic bladder, especially in China, and the results are promising but varying. Thus, the aim of this work is to assess the efficacy and safety of various Chinese medicine therapies for neurogenic bladder after spinal cord injury. Condition being studied: Chinese medicine therapies; Neurogenic bladder after spinal cord injury. Main outcome(s): The primary outcome of our NMA will be measured by overall response rate and urodynamic tests, which includes postvoiding residual urine volume, maximum urinary flow rate, and maximal detrusor pressure.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'ASM dysfunction' for particular source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography