Journal articles: 'Ascorbic Acid Cataract'

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LOHMANN, W. "Ascorbic Acid and Cataract." Annals of the New York Academy of Sciences 498, no. 1 Third Confere (July 1987): 307–11. http://dx.doi.org/10.1111/j.1749-6632.1987.tb23769.x.

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Pokharel, Shailesh Mani, Poonam Lavaju, Bhuwan Govinda Shrestha, Seraj Ahmed Khan, and Sangeeta Shah. "Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract." Journal of Nobel Medical College 9, no. 1 (June 17, 2020): 36–40. http://dx.doi.org/10.3126/jonmc.v9i1.29491.

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Background: Age-related cataract is one of the most important causes of preventable blindness among elderly population in the world. Among various causes of cataract, the level of ascorbic acid in the plasma and aqueous humor is an important parameter that can prevent cataract formation. The level of ascorbic acid in the plasma and aqueous humor is also an indicator of various morphological pattern of cataract. Materials and Methods: A hospital-based cross-sectional study was conducted among 136 patients with immature age-related cataract (≥50 years) who underwent Manual Small Incision Cataract Surgery in the Ophthalmology Department of BPKIHS for the duration of 1 year. Plasma and aqueous humor ascorbic acid levels were determined by standard competitive ELISA test. Results: Ascorbic acid concentrations in aqueous humor as well as plasma were statistically significant with the nuclear type of cataract (p<0.001). There was a positive correlation between plasma and aqueous ascorbic acid level with r = 0.532 and p<0.001. Conclusion: The finding of the study concludes that nuclear type of cataract has a strong association with both aqueous humor and plasma ascorbic acid level.

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Lohmann, W., M. Wunderling, W. Schmehl, J. Strobel, and K. G. Bensch. "Nuclear cataract and ascorbic acid." Naturwissenschaften 73, no. 5 (May 1986): 266–67. http://dx.doi.org/10.1007/bf00367780.

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Ringvold, Amund, Harald Johnsen, and Sigmund Blika. "Senile cataract and ascorbic acid loading." Acta Ophthalmologica 63, no. 3 (May 27, 2009): 277–80. http://dx.doi.org/10.1111/j.1755-3768.1985.tb06805.x.

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N. Mahajan, K., A. K. Singhai, and G. P. Vadnere. "Investigation on Anticataract Activity of Triphala Ghrita." E-Journal of Chemistry 8, no. 3 (2011): 1438–43. http://dx.doi.org/10.1155/2011/571627.

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Lab prepared Triphala ghrita was studied for its possible anticataract activity on galactose induced cataract in Swiss albino rats. Administration of Triphala ghrita at a dose of 216 mg/200 g, 1080 mg/200 g and 2160 mg/200 g of rat orally offered significant dose dependent protection against galactose induced cataract and delayed the onset and progression of cataract. It was seen that the dose of 1080 mg of Triphala ghrita did not show stage II cataract in 14 days and stage III in 21 days. It did not show even stage III and stage IV cataract after 30 days whereas group B and group C showed stage III and stage IV cataracts. Dose of 2160 mg did not showed stage IV cataract after 30 days but showed stage III cataract. Dose of 1080 mg of Triphala ghrita offered significant protection against delaying the onset and progression of cataract in comparison to other doses. This effect may be attributed to the antioxidant activity of gallic acid, ellagic acid and ascorbic acid which shows their presence in Triphala ghrita. This preliminary study was encouraging but further studies are required to extrapolate the clinical usefulness of this formulation.

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Bensch, K. G., J. E. Fleming, and W. Lohmann. "The role of ascorbic acid in senile cataract." Proceedings of the National Academy of Sciences 82, no. 21 (November 1, 1985): 7193–96. http://dx.doi.org/10.1073/pnas.82.21.7193.

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Aware, Rinkal R., Hemant J. Pagar, Ganesh D. Barkade, and Shweta Dhawane. "Anticataract activity of pioglitazone by using in-Vitro goat lens model." Indian Journal of Pharmacy and Pharmacology 8, no. 3 (September 15, 2021): 208–11. http://dx.doi.org/10.18231/j.ijpp.2021.036.

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In the present study we have selected antioxidants agents like Pioglitazone and Ascorbic acid were subjected for anti-cataract activity by in vitro glucose induced cataract model. In the procedure, goat lenses was incubated along with the aqueous humor solution containing 55mM glucose with Enalpril as a standard compound and Pioglitazone with varied concentration for the time interval of 72 hours at room temperature. There was a formation of blur layer on the goat eyeball occurs after 10-12 hours and this process complete after 72 hours. The cataract inducing lenses showing higher level of Na, MDA (P<0.001) along with the decreases in sodium-potassium ATPase activity and water-soluble protein content. The goat lenses treated with Ascorbic acid 40 µg/ml and Pioglitazone in concentrations of 15, 30, and 60 µg/ml showed increased protein content and prevent the formation of cataract.

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Angirekula, Saseekala, Lalitsiri Atti, and Srihari Atti. "Estimation of serum ascorbic acid (vitamin C) in various morphological types and clinical stages of age related (senile cataract)." International Journal of Research in Medical Sciences 6, no. 3 (February 22, 2018): 893. http://dx.doi.org/10.18203/2320-6012.ijrms20180610.

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Background: The aim was to estimate the serum ascorbic acid (vitamin C) in the various morphological types and clinical stages of age related (senile) cataract, a common cause of curable blindness globally, especially in India.Methods: This was a study of estimation of serum ascorbic acid (vitamin C) in 100 cases of senile (age related) cataract with 60 cases of senile cortical type (30 cases of immature and 30 cases of mature) and 40 cases of senile nuclear type (20 cases of grades I and II and 20 cases of grades III and IV) in the age group of 45 to 70 years.Results: Vitamin C mean plasma level was significantly decreased in senile cataract (0.54±0.23mg/dl or 30.68±13.07umol) and in its morphological types of cortical and Nuclear, especially in the later stages or grades of maturity when compared with the earlier stages or grades of immaturity i.e. The mean level of Serum Ascorbic acid was 0.55±0.23 mg/dl ((31.25±13.07umol) in Senile Cortical cataract with 0.58±0.24 mg/dl (32.96±13.64umol) in its Immature stage and 0.52±0.20mg/dl (29.55±11.36umol) in its mature stage and the mean level in Senile Nuclear cataract was 0.54±0.23mg/dl (30.68±13.7umol) with 0.56±0.29mg/dl (31.82±16.48umol) in its Grades I and II and 0.52±0.22mg/dl (29.55±12.5umol) in its Grades III and IV.Conclusions: So, our study showed significantly decreased levels of serum vitamin C in all the morphological types and clinical stages of senile cataract especially in the later stages or grades of maturity compared to the earlier clinical stages or grades of immaturity.

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Ohta, Yoshiji, Takafumi Niwa, and Takashi Yamasaki. "Effect of Prolonged Marginal Ascorbic Acid Deficiency on Lenticular Levels of Antioxidants and Lipid Peroxide in Guinea Pigs." International Journal for Vitamin and Nutrition Research 71, no. 2 (March 1, 2001): 103–9. http://dx.doi.org/10.1024/0300-9831.71.2.103.

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We examined the effect of prolonged marginal ascorbic acid deficiency of the levels of antioxidants and lipid peroxide in lenses of guinea pigs in order to clarify lenticular antioxidant status under ascorbic acid deficiency. Male guinea pigs aged 4 weeks were given a scorbutic diet (20 g/animal per day) with either marginally deficient ascorbic acid (0.5 mg/animal per day) or sufficient ascorbic acid (1 g/animal per day) in drinking water for 3 and 6 months. The deficient group showed no lens opacity during the administration period. The deficient group had 62.3 and 53.9% of lenticular ascorbic acid content in the sufficient group at 3 and 6 months of ascorbic acid deficiency, respectively. There were no differences in lenticular contents of reduced glutathione and thiobarbituric acid reactive substances, an index of lipid peroxidation, between both groups at 3 and 6 months of ascorbic acid deficiency, while the deficient group tended to have higher lenticular vitamin E content than the sufficient group. The deficient group had higher serum vitamin E concentration than the sufficient group at 3 and 6 months of ascorbic acid deficiency. These results indicate that lenticular antioxidant status is maintained well in guinea pigs with prolonged marginal ascorbic acid deficiency, which may result in no cataract formation.

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Canadananovic, Vladimir, Slobodanka Latinovic, Sava Barisic, Nikola Babic, and Sandra Jovanovic. "Age-related changes of vitamin C levels in aqueous humour." Vojnosanitetski pregled 72, no. 9 (2015): 823–26. http://dx.doi.org/10.2298/vsp131212063c.

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Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to evaluate the age-related change of vitamin C (L-ascorbic acid) level in the aqueous humor of patients with senile cataract. Methods. This prospective study included 74 patients, divided into 3 age groups, with age-related cataract, underwent routine phaco cataract surgery with intraocular lens implantation. Aqueous humor was aspirated from 74 eyes at the beginning of phacoemulsification. The levels of vitamin C (L-ascorbic acid) in aqueous humor were determined with high-performance liquid chromatography (HPLC). Results. The average age of patients included in the study was 65 ? 9.85 years (54-87 years). The level of vitamin C in aqueous humor was 152.78 ? 7.0125 ?g/mL in the group A (50-59 years), 134.15 ? 5.1569 ?g/mL in the group B (60-69 years) and 106.51 ? 5.44 ?g/mL in the group C (over 70 years). Conclusion. The amount of vitamin C in aqueous humor of patients with age-related cataract is decreasing with age. There was a statistically significant change (p < 0.001) of vitamin C aqueous concentration in the patients of different age. This decrease could play a role in susceptibility to cataract formation in older population.

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Cheng, Rongzhu, Bin Lin, Kwang-Won Lee, and Beryl J. Ortwerth. "Similarity of the yellow chromophores isolated from human cataracts with those from ascorbic acid-modified calf lens proteins: evidence for ascorbic acid glycation during cataract formation." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1537, no. 1 (July 2001): 14–26. http://dx.doi.org/10.1016/s0925-4439(01)00051-5.

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Gilje, Kristian. "HAS SATURATION WITH ASCORBIC ACID ANY INFLUENCE UPON HEMORRHAGES AFTER CATARACT OPERATION?" Acta Ophthalmologica 23, no. 2 (May 27, 2009): 127–34. http://dx.doi.org/10.1111/j.1755-3768.1945.tb04502.x.

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Kisic, Bojana, Dijana Miric, Lepsa Zoric, Aleksandra Ilic, and Ilija Dragojevic. "Antioxidant Capacity of Lenses with Age-Related Cataract." Oxidative Medicine and Cellular Longevity 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/467130.

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The immediate cause of the occurrence of cataract is unknown, but oxidative damage and effects of reactive oxygen species are considered important in its etiopathogenesis. Our research was aimed at testing the nonenzyme antioxidant power of corticonuclear lens blocks, with different types and different maturity of age-related cataract. Clinical and biochemical researches were carried out in 101 patients with age-related cataract. In corticonuclear lens blocks of the patient, the concentration of nonprotein and total-SH groups and the concentration of total vitamin C and dehydroascorbic acid (DHA) were determined; the current redox balance of dehydroascorbate/ascorbate and total antioxidant power measured by ferric-reducing ability were examined. In corticonuclear lens blocks with incipient cataract a significantly higher concentration of GSH, total SH groups, concentration of total vitamin C and ascorbic acid (AA), and ferric-reducing ability were measured. The measured concentration of DHA is higher than the concentration of AA in the lenses with the incipient and mature cataract. The concentration ratio of redox couple DHA/AA is higher in lenses with mature cataract, where the measured concentration of AA was lower than in the incipient cataract. Timely removal of DHA from the lens is important because of its potential toxicity as an oxidant. An increase of the current concentration of DHA/AA redox balance can be an indicator of oxidative stress.

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Simon, Joel A., and Esther S. Hudes. "Serum Ascorbic Acid and Other Correlates of Self-Reported Cataract Among Older Americans." Journal of Clinical Epidemiology 52, no. 12 (December 1999): 1207–11. http://dx.doi.org/10.1016/s0895-4356(99)00110-9.

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Nishigori, Hideo, Rume Hayashi, Jung W. Lee, Kazuo Maruyama, and Motoharu Iwatsuru. "Preventive effect of ascorbic acid against glucocorticoid-induced cataract formation of developing chick embryos." Experimental Eye Research 40, no. 3 (March 1985): 445–51. http://dx.doi.org/10.1016/0014-4835(85)90157-5.

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Wang, Hung Ru, Mei-Lan Ko, Yu-Lin Wang, and Jung-Chih Chen. "Bio-Electrochemical Analysis of L-Ascorbic Acid Concentration in between Glaucoma/Cataract Patients Aqueous Humor." ECS Meeting Abstracts MA2020-01, no. 25 (May 1, 2020): 1423. http://dx.doi.org/10.1149/ma2020-01251423mtgabs.

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Jalal, Derkhshandeh, Fooladsaz Koorosh, and Heydarpour Fereidoun. "Comparative Study of Plasma Ascorbic Acid Levels in Senile Cataract Patients and in Normal Individuals." Current Eye Research 34, no. 2 (January 2009): 118–22. http://dx.doi.org/10.1080/02713680802632599.

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Nourmohammadi, I., M. Modarress, K. Khanaki, and M. Shaabani. "Association of Serum α-Tocopherol, Retinol and Ascorbic Acid with the Risk of Cataract Development." Annals of Nutrition and Metabolism 52, no. 4 (2008): 296–98. http://dx.doi.org/10.1159/000148189.

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NAGATA, MASANOBU, HIDETOSHI TANIOKA, HIROYUKI MIBU, MITSUSHI HIKIDA, MASANORI AKIBA, and ITARU YAMAMOTO. "Effect of Ascorbic Acid 2-0-α-Glucoside on Hydrocortisone-Induced Cataract Formation in Developing Chick Embryos: I. Comparison of the Preventive Effect of Ascorbic Acid Derivatives." Journal of Ocular Pharmacology and Therapeutics 9, no. 1 (January 1993): 59–68. http://dx.doi.org/10.1089/jop.1993.9.59.

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Huang, Wenhu, Anna Koralewska-Makár, Birgitta Bauer, and Björn Åkesson. "Extracellular glutathione peroxidase and ascorbic acid in aqueous humor and serum of patients operated on for cataract." Clinica Chimica Acta 261, no. 2 (May 1997): 117–30. http://dx.doi.org/10.1016/s0009-8981(97)06520-0.

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Nishigori, Hideo, Jung W. Lee, Yasuhisa Yamauchi, and Motoharu Iwatsuru. "The alteration of lipid peroxide in glucocorticoid-induced cataract of developing chick embryos and the effect of ascorbic acid." Current Eye Research 5, no. 1 (January 1986): 37–40. http://dx.doi.org/10.3109/02713688608995163.

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Cheng, Rongzhu, Qi Feng, and Beryl J. Ortwerth. "LC-MS display of the total modified amino acids in cataract lens proteins and in lens proteins glycated by ascorbic acid in vitro." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1762, no. 5 (May 2006): 533–43. http://dx.doi.org/10.1016/j.bbadis.2006.01.009.

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Singh, Ram Lakhan, and Pankaj Singh. "Quantification of Phytochemicals Imparting Antioxidant Activities in Commonly Used Vegetables." International Journal of Applied Sciences and Biotechnology 6, no. 2 (June 29, 2018): 97–102. http://dx.doi.org/10.3126/ijasbt.v6i2.19636.

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Plant derived phytochemicals have recently became of great importance in the protection of various diseases, like heart disease, cardiovascular disease, cancer, diabetes, Alzheimer’s disease, cataract and age related functional disorders caused by free radicals. The present study was carried out to explore the commonly used vegetables having higher content of antioxidant imparting phytochemicals such as ascorbic acid, carotenoids, total phenolic content, carbohydrate and protein content in commonly used vegetables. The results revealed that the concentration among tested samples ranged from 7.07 mg/100g of FW (Momardica charantia leaf) to 174.15 mg/100g of FW (Allium sativum leaf) for ascorbic acid; 1.31 µg/g of FW (Chenopodium album leaf) to 14.00 µg/g of FW (Allium sativum leaf ) for carotenoid content; 8.72 mg of GAE/g of DW (Cucurbita maxima fruit) to 67.20 mg/g of DW (Colocasia esculentum leaf) for total phenolic content; 27.15 mg/g (Laginaria vulgaris leaf) to 901.00 mg/g (Cucurbita maxima fruit) for carbohydrate content and 35.96 mg/g (Amarphophyllus fruit) to 589.23 mg/g (Beta vulgaris fruit) for protein content. Results also showed that these bioactive phytochemicals are widely distributed in the vegetables and their concentrations are variable in different vegetables as well as vegetable part’s itself. Hence, vegetable rich diet having higher content of phytochemicals can be used to cure or in the prevention of various chronic diseases such as hepatotoxicity, diabetes, cardiovascular diseases, cancer, oxidative stress etc and may serve as a good source of nutraceuticals which have potential for use in health care formulations.Int. J. Appl. Sci. Biotechnol. Vol 6(2): 97-102

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Naseer, Sumra, Shabbir Hussain, and Zark Zahid. "Nutritional and Antioxidant Potential of Common Vegetables in Pakistan." RADS Journal of Biological Research & Applied Sciences 10, no. 1 (July 16, 2019): 36–40. http://dx.doi.org/10.37962/jbas.v10i1.146.

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Vegetables contain many important antioxidants and nutrients. Daucus carota L (carrot) is rich in hydrophilic and lipophilic antioxidants and is a good source of carbohydrates, vitamins, and minerals such as Ca, Mg, P, and Fe. It shows anti-carcinogenic, antioxidant, and immune boosting properties. It also provides protection against muscular degradation and development of senile cataract and reduces the risk of many diseases in humans. The nutritional value of Cucurbita pepo Linn (pumpkin) is attributed to the high level of carotenoids, carbohydrates, vitamins, other minerals. Pumpkin due to the presence of vitamin B complex, Ca and P, provides protection against many acute and chronic diseases. Pumpkin peel and pulp are the good source of antioxidants, polyphenols, carotenoids, dietary fiber and minerals such as P and Fe. Pumpkin extract shows antioxidant, antimicrobial and other activities. Spinacia oleracea (spinach) is a good source of essential nutrients such as carotenoids, vitamins, and minerals (P, K, Mg). Its leaves contain carotenoids, polyphenols, flavonoids, and ascorbic acid. Fresh spinach extract shows antioxidant and antimicrobial activity. Solanum tuberosum (potato) is rich in starch, alkaloids, flavonoids, dietary fiber, and some other minerals (K, Mg, Fe). Potato helps to overcome chronic and acute diseases and has an impact on blood pressure and gut health.

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Mohan, Hridya, and Rajini K.C. "A STUDY OF ASCORBIC ACID CONCENTRATION IN THE AQUEOUS HUMOR AND INTRA OPERATIVE CHALLENGES DURING CATARACT SURGERY IN PATIENTS WITH PSEUDO EXFOLIATION AS COMPARED TO NORMAL." Journal of Evidence Based Medicine and Healthcare 2, no. 31 (July 30, 2015): 4540–47. http://dx.doi.org/10.18410/jebmh/2015/640.

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Rani, Lata, Neelam Sharma, Sukhbir Singh, and Ajmer Singh Grewal. "Therapeutic Potential of Vitamin C: An Overview of Various Biological Activities." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 10, no. 04 (December 21, 2019): 605–12. http://dx.doi.org/10.25258/ijpqa.10.4.8.

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Vitamins are vital nutrients that are required for different body functions properly, and they are provided to the body externally through diet. Vitamin C, also known as ascorbic acid, is an essential nutrient that is required for the proper running of different body functions. It is a water-soluble vitamin and lost during the processing of food. The main sources of vitamin C are citrus fruits (kakadu plum, acerola cherries, guavas, kiwi, lemon, lychees, kale, oranges, peaches, tomatoes, black currant, thyme, parsley, rose hips, kale and strawberries), green leafy vegetables (chilli peppers, tomato, sweet yellow peppers, parsley, brussel sprouts, potatoes, mustard spinach and broccoli), fortified cereal and some animals. Vitamin C deficiency leads to scurvy, which mainly affects older, malnourished adults. Vitamin C acts as a strong antioxidant, and this property enriches various biological activities. It is believed that high dose of vitamin C may help in reducing the risk of various diseases like cancer, diabetes, cardiovascular disorders, blood pressure, respiratory syndromes, common cold, reproduction, cognitive diseases, skin problems, age-related muscular degeneration, cataract and may enhance immunity. This mini-review article has been planned to discuss sources, deficiency symptoms, daily requirements, therapeutic potential, and various biological activities of vitamin C. Various therapeutic and pharmacological activities of vitamin C will be discussed in detail with suitable examples.

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NAGATA, MASANOBU, MITSUSHI HIKIDA, HIROYUKI MIBU, NORIO MUTO, and ITARU YAMAMOTO. "Effect of Ascorbic Acid 2-O-α-Glucoside on Hydrocortisone-Induced Cataract Formation in Developing Chick Embryos: II. Influence on Glutathione and Lipid Peroxide Contents in the Lens." Journal of Ocular Pharmacology and Therapeutics 10, no. 3 (January 1994): 537–42. http://dx.doi.org/10.1089/jop.1994.10.537.

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Olmedilla, Begoña, Fernando Granado, Susan Southon, Anthony J. A. Wright, Inmaculada Blanco, Enrique Gil-Martinez, Henk van den Berg, et al. "Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries." British Journal of Nutrition 85, no. 2 (February 2001): 227–38. http://dx.doi.org/10.1079/bjn2000248.

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High intakes of fruits and vegetables, or high circulating levels of their biomarkers (carotenoids, vitamins C and E), have been associated with a relatively low incidence of cardiovascular disease, cataract and cancer. Exposure to a high fruit and vegetable diet increases antioxidant concentrations in blood and body tissues, and potentially protects against oxidative damage to cells and tissues. This paper describes blood concentrations of carotenoids, tocopherols, ascorbic acid and retinol in well-defined groups of healthy, non-smokers, aged 25–45 years, 175 men and 174 women from five European countries (France, UK (Northern Ireland), Republic of Ireland, The Netherlands and Spain). Analysis was centralised and performed within 18 months. Within-gender, vitamin C showed no significant differences between centres. Females in France, Republic of Ireland and Spain had significantly higher plasma vitamin C concentrations than their male counterparts. Serum retinol and α-tocopherol levels were similar between centres, but γ-tocopherol showed a great variability being the lowest in Spain and France, and the highest in The Netherlands. The provitamin A: non-provitamin A carotenoid ratio was similar among countries, whereas the xanthophylls (lutein, zeaxanthin, β-cryptoxanthin) to carotenes (α-carotene, β-carotene, lycopene) ratio was double in southern (Spain) compared to the northern areas (Northern Ireland and Republic of Ireland). Serum concentrations of lutein and zeaxanthin were highest in France and Spain; β-cryptoxanthin was highest in Spain and The Netherlands;trans-lycopene tended to be highest in Irish males and lowest in Spanish males; α-carotene and β-carotene were higher in the French volunteers. Due to the study design, the concentrations of carotenoids and vitamins A, C and E represent physiological ranges achievable by dietary means and may be considered as ‘reference values’ in serum of healthy, non-smoking middle-aged subjects from five European countries. The results suggest that lutein (and zeaxanthin), β-cryptoxanthin, total xanthophylls and γ-tocopherol (and α- : γ-tocopherol) may be important markers related to the healthy or protective effects of the Mediterranean-like diet.

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Herawati, Netti, and Firdaus Firdaus. "3,3’-di-O-methylellagic acid, an Antioxidant Phenolics Compound from Sonneratia alba Bark." Jurnal Natur Indonesia 15, no. 1 (July 14, 2014): 63. http://dx.doi.org/10.31258/jnat.15.1.63-67.

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Free radicals play an important role in some pathogenesis of serious diseases, such as neurodegenerative disorders, cancer,liver cirrhosis, cardiovascular diseases, atherosclerosis, cataracts, diabetes and inflammation. Compounds that can scavengefree radicals have great potential in ameliorating these diseases. It is reported that phenolic compounds in plants possessstrong antioxidant activity and may help to protect cells against the oxidative damage caused by free radicals. Previousstudy revealed that mangrove trees, Sonneratia alba Bark showed strong antioxidant activity. Ethyl acetate fractionexhibited the best antioxidant performance. The antioxidant activity of this fraction was attributed to the presence ofcompounds of different polarities such as phenolics. Furthermore, the phenolic antioxidant of ethyl acetate fraction werepurified and identified with UV, IR, MS, and 2D NMR spectrometry. 3,3’-di-O-methylellagic acid was found in brownamourphous powder. Antioxidant activity was evaluated and compared with L-(+)-ascorbic acid as standard by usingDPPH assay. The compound has strong antioxidant activity than ascorbic acid standar with the value of IC 50 11.35 and17.64 μg/mL, respectively. The high value of antioxidant activity of compound indicate that S. alba is a potential source ofnatural antioxidant agent.

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Umapathy, Ankita, Paul Donaldson, and Julie Lim. "Antioxidant Delivery Pathways in the Anterior Eye." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/207250.

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Tissues in the anterior segment of the eye are particular vulnerable to oxidative stress. To minimise oxidative stress, ocular tissues utilise a range of antioxidant defence systems which include nonenzymatic and enzymatic antioxidants in combination with repair and chaperone systems. However, as we age our antioxidant defence systems are overwhelmed resulting in increased oxidative stress and damage to tissues of the eye and the onset of various ocular pathologies such as corneal opacities, lens cataracts, and glaucoma. While it is well established that nonenzymatic antioxidants such as ascorbic acid and glutathione are important in protecting ocular tissues from oxidative stress, less is known about the delivery mechanisms used to accumulate these endogenous antioxidants in the different tissues of the eye. This review aims to summarise what is currently known about the antioxidant transport pathways in the anterior eye and how a deeper understanding of these transport systems with respect to ocular physiology could be used to increase antioxidant levels and delay the onset of eye diseases.

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Linnér, Erik. "THE RATE OF PLASMA FLOW THROUGH THE CILIARY PROCESSES IN SENILE CATARACTS MEASURED BY MEANS OF ASCORBIC ACID." Acta Ophthalmologica 32, no. 3 (June 25, 2009): 213–26. http://dx.doi.org/10.1111/j.1755-3768.1954.tb05044.x.

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Paudel, Mukti Ram, Mukesh Babu Chand, Basant Pant, and Bijaya Pant. "Assessment of Antioxidant and Cytotoxic Activities of Extracts of Dendrobium crepidatum." Biomolecules 9, no. 9 (September 12, 2019): 478. http://dx.doi.org/10.3390/biom9090478.

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Dendrobium crepidatum is an epiphytic orchid found in south Asia including Nepal and China. This orchid species is widely used in traditional Chinese medicine (TCM) for the treatment of cancer, diabetes, cataracts, and fever. The objectives of the present research were to assess the antioxidant and cytotoxic properties of its stem’s extracts with the identification of bioactive secondary metabolites. The antioxidant and cytotoxic activities were evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays, respectively, and compounds were identified using GC–MS (gas chromatography and mass spectrometry). Ethanol and acetone extracts scavenged 94.69 ± 0.10% and 93.41 ± 0.86% of DPPH free radicals, respectively. They showed 50% inhibition of DPPH free radicals (IC50) at concentrations of 73.90 µg/mL and 99.44 µg/mL, which were found to be statistically similar to that of ascorbic acid (control). Chloroform extract inhibited the growth of 81.49 ± 0.43% of HeLa (human cervical carcinoma) cells and hexane extract inhibited the growth of 76.45 ± 4.26% of U251 (human glioblastoma) cells at 800 µg/mL concentration. These extracts showed 50% inhibition of cell growth (IC50) toward both the HeLa and U251 cell lines at their high concentrations, which were found statistically significantly different from that of cisplatin drug (control). The above extracts showed antioxidant and cytotoxic properties, potentially due to the presence of tetracosane, triacontane, stigmasterol, and some phenol derivatives (2-methoxy-4-vinylphenol, 2-methoxy-5-(1-propenyl)-phenol, p-mesyloxyphenol, and 2,6-dimethoxy-4-(2-propenyl)-phenol). This study explores the potential of this orchid in alternative medicine toward the development of drugs from its medicinally active compounds.

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Olisekodiaka, M. J., A. Adedoyin, A. J. Onuegbu, M. O. Ebesunun, and E. O. Agbedana. "Plasma Ascorbic Acid and Non-Enzymatic Antioxidants Level in Unoperated Cataract Patients." Nigerian Journal of Health and Biomedical Sciences 6, no. 1 (August 22, 2007). http://dx.doi.org/10.4314/njhbs.v6i1.11619.

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Hah, Young-Sool, Hye Jin Chung, Sneha B. Sontakke, In-Young Chung, Sunmi Ju, Seong-Wook Seo, Ji-Myong Yoo, and Seong-Jae Kim. "Ascorbic acid concentrations in aqueous humor after systemic vitamin C supplementation in patients with cataract: pilot study." BMC Ophthalmology 17, no. 1 (July 11, 2017). http://dx.doi.org/10.1186/s12886-017-0515-2.

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Angirekula, Saseekala, Lalitsiri Atti, and Srihari Atti. "Estimation of Serum Ascorbic Acid (Vitamin C) In the Age Related (Senile) Cataract: a Case Control Study." Annals of Clinical and Laboratory Research 06, no. 01 (2018). http://dx.doi.org/10.21767/2386-5180.1000217.

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Zengeni, S., J. M. Chifamba, I. Mutingwende, and T. Manyarara. "Investigation of the Phytochemistry and Antioxidant Activity of Pterocarpus angolensis (Mubvamaropa) from Mupandawana." International Journal of Biochemistry Research & Review, September 13, 2021, 29–36. http://dx.doi.org/10.9734/ijbcrr/2021/v30i530267.

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The present study investigated the phytochemistry and antioxidant activity of Pterocarpus angolensis (Mubvamaropa) from Mupandawana. Pt. angolensis has numerous medicinal uses. The bark, sap, leaves and roots are all used to treat different ailments. The sap is used to stop nose bleeds, treatment of ulcers and kill ringworms. Several studies have supported the use of the tree’s sap to treat cataracts, malaria as well as skin inflammations. Pterocarpus angolensis bark was collected from Gutu, Masvingo province and authenticated by a plant taxonomist at the Zimbabwe National herbarium (Mr Chapano). The bark was cleaned using distilled water and oven dried at 40°C for 4 hours to constant weight. Size reduction was achieved using a Thomas-Wiley laboratory mill model with a 2 mm sieve mesh. The phytochemical analysis revealed that the ethanolic extract had more phyto-constituents than the water extract which only four phyto-constituents present all of which were weakly positive. DPPH scavenging activity was 95.11% at a concentration of 500 μg/mL bark extract, while that of the control, ascorbic acid, was 97.60%. Ascorbic acid had an IC50 value of 4.35 µg/mL while the bark extract had a value of 150.64 µg/mL.

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Journal articles on the topic 'Ascorbic Acid Cataract'

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