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Journal articles on the topic 'AS7G06'

Author: Grafiati

Published: 23 September 2022

Last updated: 28 January 2023

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1

Mu, P., Y. Nadot, I. Serrano-Munoz, and A. Chabod. "Influence of complex defect on cast AS7G06-T6 under multiaxial fatigue loading." Engineering Fracture Mechanics 123 (June 2014): 148–62. http://dx.doi.org/10.1016/j.engfracmech.2014.02.012.

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2

Mu, P., Y. Nadot, C. Nadot-Martin, A. Chabod, I. Serrano-Munoz, and C. Verdu. "Influence of casting defects on the fatigue behavior of cast aluminum AS7G06-T6." International Journal of Fatigue 63 (June 2014): 97–109. http://dx.doi.org/10.1016/j.ijfatigue.2014.01.011.

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3

Muzamil, Muhammad, Maaz Akhtar, Muhammad Samiuddin, and Murtuza Mehdi. "Effect of heat treatment on impact resistance of AU5GT and AS7G06 aluminum alloys." Journal of Mechanical Science and Technology 30, no. 10 (October 2016): 4543–48. http://dx.doi.org/10.1007/s12206-016-0924-9.

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4

Mu, P., Y. Nadot, I. Serrano-Munoz, and A. Chabod. "Multiaxial fatigue design of cast parts: Influence of complex defect on cast AS7G06-T6." Engineering Fracture Mechanics 131 (November 2014): 315–28. http://dx.doi.org/10.1016/j.engfracmech.2014.08.007.

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5

Marchetti, Anna, and Frederic Zenhausern. "AR222, AR249, AS274, AS702 and AS708 antibodies recognize the spike S protein from SARS-CoV-2 by immunofluorescence." Antibody Reports 3, no. 4 (July 13, 2020): e228. http://dx.doi.org/10.24450/journals/abrep.2020.e228.

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6

Marchetti, Anna, and Frederic Zenhausern. "AI334, AQ806, AR222, AR249, AS274, AS702, AS708, RB590, RB591 and RB596 antibodies recognize the spike S protein from SARS-CoV-2 by western blot." Antibody Reports 5, no. 1 (March 29, 2022): e725. http://dx.doi.org/10.24450/journals/abrep.2022.e725.

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7

Hammel, Philippe, Anna Marchetti, and Frederic Zenhausern. "AR222, AR249, AS274, AS702 and AS708 antibodies recognize the spike S protein from SARS-CoV-2 by ELISA." Antibody Reports 3, no. 4 (June 23, 2020): e220. http://dx.doi.org/10.24450/journals/abrep.2020.e220.

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8

Inglis, G. Douglas, Jenny F. Gusse, Kathaleen E. House, Tara G. Shelton, and Eduardo N. Taboada. "Tetracycline Resistant Campylobacter jejuni Subtypes Emanating from Beef Cattle Administered Non-Therapeutic Chlortetracycline are Longitudinally Transmitted within the Production Continuum but are Not Detected in Ground Beef." Microorganisms 8, no. 1 (December 21, 2019): 23. http://dx.doi.org/10.3390/microorganisms8010023.

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The impacts of the antimicrobial growth promoter (AGP), chlortetracycline with sulfamethazine (AS700), on the development of antimicrobial resistance and longitudinal transmission of Campylobacter jejuni within the beef production continuum were empirically determined. Carriage of tetracycline resistance determinants in the enteric bacterial community increased at a greater rate for AS700-treatment cattle. The majority of the bacteria from animals administered AS700 carried tetW. Densities of C. jejuni shed in feces increased over the confined feeding period, and the administration of AS700 did not conspicuously reduce C. jejuni densities in feces or within the intestine. The majority of C. jejuni isolates recovered were resistant to tetracycline, but the resistance rates to other antibiotics was low (≤20.1%). The richness of C. jejuni subtypes recovered from AS700-treated animals that were either resistant or susceptible to tetracycline was reduced, indicating selection pressure due to AGP administration. Moreover, a degree of subtype-specific resistance to tetracycline was observed. tetO was the primary tetracycline resistance determinant conferring resistance in C. jejuni isolates recovered from cattle and people. Clinically-relevant C. jejuni subtypes (subtypes that represent a risk to human health) that were resistant to tetracycline were isolated from cattle feces, digesta, hides, the abattoir environment, and carcasses, but not from ground beef. Thus, study findings indicate that clinically-relevant C. jejuni subtypes associated with beef cattle, including those resistant to antibiotics, do not represent a significant foodborne risk.

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Lacombe, Jerome, Frederic Zenhausern, and Pierre Cosson. "AI334, AQ806, AR222, AR249, AS274, AS708, RB572, RB574 and RB596 antibodies recognize SARS-CoV-2 viral particles by dot blot." Antibody Reports 3, no. 4 (December 15, 2020): e273. http://dx.doi.org/10.24450/journals/abrep.2020.e273.

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10

Inglis, G. Douglas, Tim A. McAllister, Francis J. Larney, and Edward Topp. "Prolonged Survival of Campylobacter Species in Bovine Manure Compost." Applied and Environmental Microbiology 76, no. 4 (December 18, 2009): 1110–19. http://dx.doi.org/10.1128/aem.01902-09.

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ABSTRACT The persistence of naturally occurring campylobacteria in aerobic compost constructed of manure from beef cattle that were administered chlortetracycline and sulfamethazine (AS700) or from cattle not administered antibiotics (control) was examined. Although there were no differences in population sizes of heterotrophic bacteria, the temperature of AS700 compost was more variable and did not become as high as that of control compost. There were significant differences in water content, total carbon (C), total nitrogen (N), and electrical conductivity but not in the C/N ratio or pH between the two compost treatments. Campylobacteria were readily isolated from pen manure, for up to day 15 from control compost, and throughout the active phase of AS700 compost. Campylobacter DNA (including Campylobacter coli, Campylobacter fetus, Campylobacter hyointestinalis, and Campylobacter jejuni) was detected over the ca. 10-month composting period, and no reductions in quantities of C. jejuni DNA were observed over the duration of the active phase. The utilization of centrifugation in combination with ethidium monoazide (EMA) significantly reduced (>90%) the amplification of C. jejuni DNA that did not originate from cells with intact cell membranes. No differences were observed in the frequency of Campylobacter DNA detection between EMA- and non-EMA-treated samples, suggesting that Campylobacter DNA amplified from compost was extracted from cells with intact cell membranes (i.e., from viable cells). The findings of this study indicate that campylobacteria excreted in cattle feces persist for long periods in compost and call into question the common belief that these bacteria do not persist in manure.

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11

Jha, Abhay K., and K. Sreekumar. "Effect of pores and acicular eutectic silicon particles on the performance of Al–Si–Mg (AS7G03) casting." Engineering Failure Analysis 16, no. 7 (October 2009): 2433–39. http://dx.doi.org/10.1016/j.engfailanal.2009.04.002.

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12

Alexander, T. W., T. Reuter, R. Sharma, L. J. Yanke, E. Topp, and T. A. McAllister. "Longitudinal Characterization of Resistant Escherichia coli in Fecal Deposits from Cattle Fed Subtherapeutic Levels of Antimicrobials." Applied and Environmental Microbiology 75, no. 22 (October 2, 2009): 7125–34. http://dx.doi.org/10.1128/aem.00944-09.

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ABSTRACT Model fecal deposits from cattle fed or not fed antimicrobial growth promoters were examined over 175 days in the field for growth and persistence of total Escherichia coli and numbers and proportions of ampicillin-resistant (Ampr) and tetracycline-resistant (Tetr) E. coli. In addition, genotypic diversity and the frequency of genetic determinants encoded by Ampr and Tetr E. coli were investigated. Cattle were fed diets containing chlortetracycline (44 ppm; A44 treatment group), chlortetracycline plus sulfamethazine (both at 44 ppm; AS700 treatment group), or no antibiotics (control). Fecal deposits were sampled 12 times over 175 days. Numbers of Tetr E. coli in A44 and AS700 deposits were higher (P < 0.001) than those of controls and represented up to 35.6% and 20.2% of total E. coli, respectively. A time-by-treatment interaction (P < 0.001) was observed for the numbers of Tetr and Ampr E. coli. Except for Ampr E. coli in control deposits, all E. coli numbers increased (P < 0.001) in deposits up to day 56. Even after 175 days, high Tetr E. coli numbers were detected in A44 and AS700 deposits [5.9 log10 CFU (g dry matter)− 1 and 5.4 log10 CFU (g dry matter)− 1, respectively]. E. coli genotypes, as determined by pulsed-field gel electrophoresis, were diverse and were influenced by the antimicrobial growth promoter and the sampling time. Of the determinants screened, bla TEM1, tetA, tetB, tetC, sul1, and sul2 were frequently detected. Occurrence of determinants was influenced by the feeding of antimicrobials. Fecal deposits remain a source of resistant E. coli even after a considerable period of environmental exposure.

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13

Silva, Elizangela Selma, Marco Antonio Camillo Carvalho, and Rivanildo Dallacort. "CULTIVARES DE SOJA EM FUNÇÃO DE ELEMENTOS CLIMÁTICOS NOS MUNICÍPIOS DE TANGARÁ DA SERRA E DIAMANTINO, MT." Nativa 8, no. 2 (April 10, 2020): 157. http://dx.doi.org/10.31413/nativa.v8i2.8382.

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O objetivo deste trabalho foi avaliar a influência da temperatura e precipitação no desempenho agronômico de cultivares de soja nos municípios de Tangará da Serra e Diamantino, MT. Os experimentos foram realizados na safra 2012/13. O delineamento experimental foi blocos casualizados fatorial 2x4x6. Sendo dois locais, quatro épocas de semeadura (05/10/2012; 20/10/2012; 05/11/2012 e 20/11/2012) e seis cultivares de soja (AS7307, ANTA 82, TMG 1179, P98Y30, TMG 132 e M-SOY 9144), totalizando 48 tratamentos e três repetições. Foram realizadas as seguintes avaliações: número de vagens por planta, número de grãos por vagem, massa de mil grãos, produtividade e balanço hídrico climatológico sequencial diário. Os resultados obtidos foram submetidos à análise de variância, sendo as médias comparadas pelo teste Scott-Knott, a 5% de significância. A segunda época (20/10/12) foi a que proporcionou maior rendimento de grãos para a maioria das cultivares nos dois municípios estudados, sendo que as seis cultivares analisadas apresentaram variação na produtividade em função da época e local de cultivo. A quarta época de semeadura (05/11/12) foi a que mais influenciou na massa de mil grãos, devido a redução no ciclo das cultivares nessa época.Palavras-chave: Glycine max (L.) Merrill; épocas semeadura; temperatura; precipitação. SOYBEAN VARIETIES BASED ON CLIMATIC ELEMENTS IN THE MUNICIPALITIES OF TANGARÁ DA SERRA E DIAMANTINO, MT ABSTRACT: The objective of this study was to evaluate the influence of temperature and precipitation in the agronomic performance of six soybean cultivars sown in four seasons in the municipalities of Tangará da Serra and Diamantino, MT. The field experiments were conducted in the 20012/13 crop season. The experimental design was a randomized block with factorial treatment 2x4x6. Being two locations, four sowing seasons (10/05/2012, 10/20/2012, 11/05/2012 and 11/20/2012) and six soybean cultivars (AS7307, ANTA 82, TMG 1179, P98Y30, TMG 132 and M-SOY 9144), totaling 48 treatments and three replications. The following evaluations were conducted: number of pods per plant, number of seeds per pod, thousand grain weight, productivity and daily sequential water balance. The results were subjected to analysis of variance and the means were compared by Scott-Knott test at 5% probability. The second sowing season (10/20/12) had the highest grain yield for most of the cultivars in both municipalities. The six cultivars analyzed had variation in productivity due to the sowing season and region of cultivation. The fourth sowing season (11/05/12) was the greatest influence in thousand grain weight, due to a reduction in the cultivars cycle in this season.Keywords: Glycine max (L.) Merrill; sowing seasons; temperature; precipitation.

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14

Indarwati, Indarwati, Nurhayati Nurhayati, Lukman Lukman, and Harlina Sahib. "THE LANGUAGE ATTITUDE OF GANTARANG COMMUNITY TOWARDS KONJO LANGUAGE: A CASE STUDY IN THE REALM OF FAMILY AND SCHOOL." JOURNAL OF ADVANCED ENGLISH STUDIES 5, no. 1 (June 27, 2022): 31. http://dx.doi.org/10.47354/jaes.v5i1.135.

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This study aims to reveal the language attitude of the Konjo-speaking community in Gantarang sub-district towards the Konjo language, especially in the village of Benteng Gantarang. The methods used in this research are survey, observation, and interview methods. The results showed that53.3% of respondents Disagree, 16.7% chose to be Neutral, 10% of respondents Strongly Disagree; if the Konjo language must be taught/acquired by children at home; only 16.7% agree. As for the second statement, namely the Konjo language must be used as the main language in everyday communication at home, the response was not agree.as many as 56.7% of respondents, respondents who agree by 20% and 13.3% choose to be Neutral. The third statement, namely the Konjo language must be used in elementary schools (especially grades 1 to grade 3), was responded to disagree as much as70% and only 13.3% Agree, and the rest Strongly Disagree. Then, the 4th statement, namely the Konjo language needs to be taught in schools, as many as 56.7% of respondents stated Disagree and 26.7% stated Agree, and 10% of respondents chose to be Neutral.

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15

Youngren, Susanne R., Rakesh K. Tekade, Brianne Gustilo, Peter R. Hoffmann, and Mahavir B. Chougule. "STAT6 siRNA Matrix-Loaded Gelatin Nanocarriers: Formulation, Characterization, andEx VivoProof of Concept Using Adenocarcinoma Cells." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/858946.

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The clinical utility of siRNA therapy has been hampered due to poor cell penetration, nonspecific effects, rapid degradation, and short half-life. We herewith proposed the formulation development of STAT6 siRNA (S6S) nanotherapeutic agent by encapsulating them within gelatin nanocarriers (GNC). The prepared nanoformulation was characterized for size, charge, loading efficiency, release kinetics, stability, cytotoxicity, and gene silencing assay. The stability of S6S-GNC was also assessed under conditions of varying pH, serum level, and using electrophoretic assays.In vitrocytotoxicity performance was evaluated in human adenocarcinoma A549 cells following MTT assay. The developed formulation resulted in an average particle size, surface charge, and encapsulation efficiency as70±6.5 nm,+10±1.5 mV, and85±4.0%, respectively. S6S-GNC showed an insignificant (P<0.05) change in the size and charge in the presence of buffer solutions (pH 6.4 to 8.4) and FBS (10% v/v). A549 cells were treated with native S6S, S6S-lipofectamine, placebo-GNC, and S6S-GNC using untreated cells as a control. It was observed that cell viability was decreased significantly with S6S-GNC by55±4.1%(P<0.001) compared to native S6S (2.0±0.55%) and S6S-lipofectamine complex (40±3.1%). This investigation infers that gelatin polymer-based nanocarriers are a robust, stable, and biocompatible strategy for the delivery of siRNA.

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16

Thomas, G. E. "Remark ASR 65: A Remark on Algorithm AS76: An Integral Useful in Calculating Non-Central t and Bivariate Normal Probabilities." Applied Statistics 35, no. 3 (1986): 310. http://dx.doi.org/10.2307/2348031.

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17

Jayanti, Ery. "DAMPAK KEBIJAKAN EKSPANSIF PEMERINTAH MELALUI TUNJANGAN PRESTASI KERJA (TPK) TERHADAP PERMINTAAN AGREGAT DAN INFLASI." JURNAL PERSPEKTIF EKONOMI DARUSSALAM 3, no. 1 (April 16, 2017): 70–84. http://dx.doi.org/10.24815/jped.v3i1.6994.

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The study aimed to investigate how the effects of expansionary policies of the government through the provision of work performance benefits in the provincial government of Aceh on Aggregate Demand and Inflation. This study was conducted by using time series data for the period Januari 2010- april 2016, which is implemented in the monthly data sourced from Aceh Province Budget (DKA - ACEH), the Central Statistics Agency of Aceh (BPS-Aceh) and Bank Indonesia in Regional Financial Statistics Indicators and other institutions related to the research question. The method used was descriptive quantitative method by using Multiple Linier Regresion analysis model (OLS). This study used secondary data from Januari 2010 to april 2016. The data used was monthly data by the number of samples as many as76 months. The Results showed that there was significant effect between the expansionary policies of the government and aggregate demand, but inflation, no significally meaning that work performance insentive of the staff of the local government in Aceh would not affect. Then Fiscal Ekspansive policy implementation to do.Penelitian ini ingin melihat bagaimana pengaruh kebijakan ekspansif pemerintah melalui pemberian tunjangan prestasi kerja di Lingkungan pemerintahan Provinsi Aceh terhadap Permintaan Agregat dan Inflasi. Penelitian ini dilakukan dengan menggunakan data time series pada periode Januari 2010- April 2015, diimplementasi dalam data bulanan bersumber dari Dana Keuangan Provinsi Aceh (DKA - ACEH), Badan Pusat Statistik (BPS-Aceh) dan Bank Indonesia dalam Indikator Statistik Keuangan Daerah . Metode yang digunakan adalah Metode kuantitatif deskriptif dengan menggunakan Ordinary Least Square (OLS). Penelitian ini menggunakan data sekunder dari tahun Januari 2010 – April 2015, dengan jumlah Sampel sebanyak 76 bulan. Hasil penelitian melalui uji estimasi menunjukkan permintaan agregat secara signifikan dipengaruhi oleh pengeluaran pemerintah melalui pemberian Tunjangan Prestasi Kerja (TPK),secara positif dalam jangka panjang, Untuk variabel pengeluaran pemerintah dalam hal ini tunjangan prestasi kerja tidak berpengaruh terhadap inflasi. kesimpulannya kebijakan ekspansif ini masih bisa dijalankan.

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18

Topa, Dan, Emil Makovicky, Berthold Stoeger, and Chris Stanley. "Heptasartorite, Tl7Pb22As55 S108, enneasartorite, Tl6 Pb32 As70 S140 and hendekasartorite, Tl2Pb48As82 S172, three members of the anion-omission series of 'sartorites' from the Lengenbach quarry at Binntal, Wallis, Switzerland." European Journal of Mineralogy 29, no. 4 (October 10, 2017): 701–12. http://dx.doi.org/10.1127/ejm/2017/0029-2634.

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19

Makovicky, Emil, Dan Topa, and Berthold Stoeger. "The crystal structures of heptasartorite, Tl7 Pb22 As55S108, and enneasartorite, Tl6 Pb32 As70 S140, two members of an anion-omission series of complex sulfosalts from Lengenbach, the Swiss Alps, and comparison with the structures of As–Sb sartorite homologues." European Journal of Mineralogy 30, no. 1 (February 1, 2018): 149–64. http://dx.doi.org/10.1127/ejm/2018/0030-2706.

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20

Kusumaningrum, Puput Risti, Suyami Suyami, and Very Widiawati. "Pengaruh Latihan Gerak Pinggul (Stretching) Terhadap Skore Nyeri Pinggul Pada Lansia di Posyandu Lansia." Jurnal Perawat Indonesia 4, no. 1 (May 30, 2020): 250. http://dx.doi.org/10.32584/jpi.v4i1.256.

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Hasil wawancara dengan lansia di Posyandu pada lansia di susun Trosari menunjukkan bahwa untuk mengatasi sakit punggung, lansia biasanya pergi ke klinik untuk pemeriksaan kesehatan lansia setiap hari rabu. Lansia juga melakukan senam setiap hari untuk mendukung kebugaran fisik lansia, tetapi masih banyak lansia yang mengeluh sakit punggung yang tidak hilang telah membaik dengan menerapkan olahraga setiap hari. Tetapi latihan gerak pinggul statis belum dilakukan untuk mengurangi nyeri punggung pada lansia. Tujuan penelitian ini untuk mengetahui pengaruh pencegahan senam panggul pada nyeri skala rendah di Posyandu Lansia di Dusun Trosari, Patuk, Gunung Kidul. Desain penelitian ini menggunakan desain pre eksperimen dengan pendekatan one group pre test post test design. Teknik pengambilan sampel menggunakan teknik purposive sampling dengan jumlah sampel 10 lansia. Analisa data menggunakan paired t test. Karakteristik responden (usia ratarata 66.30 tahun, jenis kelamin laki-laki sebanyak 70%, pendidikan SD sebanyak 70% dan pekerjaan yang tidak bekerja sebanyak 40%. Skor nyeri pinggul pada lansia sebelum diberikan pencegahan latihan gerak pinggul untuk lansia di desa Trosari dusun Patuk Gunungkidul dengan rata-rata 5.8. Skor nyeri pinggul pada lansia sesudah diberikan pencegahan latihan gerak pinggul untuk lansia di desa Trosari dusun Patuk Gunungkidul dengan rata-rata 3.3. Perbedaan skor nyeri pinggul sebelum dan sesudah diberikan pencegahan latihan gerak pinggul yaitu 2.50. Terdapat pengaruh pencegahan latihan gerak pinggul untuk lansia di desa Trosari dusun Patuk Gunungkidul. The results of the interview with the elderly at the Posyandu in the elderly inTrosari hamlet show that to deal with back pain, the elderly usually go to theclinic for an elderly health check every Wednesday. Elderly also take gymnasticsevery day to support the physical fitness of the elderly, but there are still many elderlypeople who complain that their back pain that never goes away has improved eventhough it has been applied to exercise every day. However, Static Stretching exerciseshave not been carried out to reduce back pain in the elderly. The aim of the study wasto determine the effect of Gymnastics Prevention of Low Pain on the Scales of Hip Painin the Elderly at the Elderly Posyandu in Trosari Hamlet, Patuk Gunungkidul. Thedesign of this study used Pre Experimental with the design of the One Group Pre TestPostTest Design. The purposive sampling sampling technique is 10 people. Dataanalysis using paired t-test. Characteristics of respondents (age with a mean of 66.30years, gender is male as much as 70%, education ie elementary school as much as70% and work that is not working as much as 40%). Hip pain scoring in the elderlybefore being given the Pain Relief Gymnastics Prevention in the Elderly Village ofTrosari Hamlet Patuk Gunungkidul with an average of 5.8. Scores of hip pain in the elderly after being given Elderly Pain Prevention of Lower Back Pain Exercise in Trosari Patuk Hamlet, Gunungkidul with an average of 3.3. Differences in hip pain scores before and after Low Back Pain Prevention Gymnastics were 2.50. There is the effect of Gymnastics Prevention of Low Back Pain Against Hip Pain in the Elderly at the Elderly Village of Trosari Hamlet Patuk Gunungkidul

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21

Marzo-Ortega, H., X. Juanola, T. Okano, Y. Schymura, A. Bradley, J. Gerwien, B. Monsberger, S. Liu Leage, D. Aletaha, and M. Østergaard. "POS0926 NORMALIZATION OF HIGH SENSITIVITY CRP VERSUS CLINICAL RESPONSE TO IXEKIZUMAB AT WEEK 16 IN PATIENTS WITH RADIOGRAPHIC & NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM THE COAST STUDIES." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 725–26. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2079.

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Background:C-reactive protein (CRP), an objective marker of inflammation, can be used to monitor treatment response to biologics in patients with axial spondyloarthritis (axSpA) in addition to evaluating signs & symptoms. CRP is not elevated in all patients with active axSpA questioning its validity as a universal biomarker of response. Ixekizumab (IXE) demonstrated efficacy in axSpA treatment irrespective of baseline (BL) CRP levels. However, response to IXE categorized on CRP change from BL is unknown.Objectives:To evaluate response to IXE treatment from BL through week (wk) 16 in patients with axSpA categorized according to change in high sensitivity (hs) CRP.Methods:COAST-V (NCT 02696785),-W (NCT02696798), & -X (NCT02757352), were phase 3, multicentre, randomized, controlled trials, investigating the efficacy of IXE 80 mg every 4 & 2 wks in patients with: r-axSpA naïve to biologic disease-modifying antirheumatic drugs (bDMARDs; COAST-V); or who were inadequate responders/intolerant to tumour necrosis factor inhibitors (TNFi; COAST-W); or who fulfilled Assessment of SpondyloArthritis International Society (ASAS) criteria for non-radiographic (nr)axSpA (COAST-X).This post hoc analysis focuses on approved dosing regimens. Depending on BL and wk 16 hsCRP values, patients were categorised as stable low (hsCRP ≤5 mg/L at BL & ≤5 mg/L at wk 16), normalized (hsCRP >5 mg/L at BL & ≤5 mg/L at wk 16) or elevated (hsCRP >5 mg/L at wk 16, irrespective of BL hsCRP). An absolute cutoff of 5 mg/L was used as the stratification factor in all COAST studies. Data were analyzed by treatment arm. Each trial was analyzed separately.For hsCRP subgroups, patient demographics & other characteristics at BL, as well as trajectory over time for the endpoints ASAS40 & Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) 50 are described. Non-responder imputation was used for missing values.Results:In all studies at BL, disease activity & MRI SPARCC score were higher in normalized & elevated subgroups compared to the stable low subgroup - a.In COAST-V, ASAS40 & BASDAI50 response was observed in IXE-treated patients regardless of hsCRP change status by wk 16 vs placebo. The highest ASAS40 & BASDAI50 response rate was reported in patients with normalized hsCRP - b. Similar findings were observed in COAST-W & -X.Table 1.Baseline Patient demographics & other characteristics - ITT population, per CRP subgroupCOAST-V(r-axSpA, bDMARD naive)COAST-W(r-axSpA, inadequate responders /intolerant to TNFi)COAST-X(non-radiographic axSpA, bDMARD naïve)Stable low (n=79)Norma-lized (n=80)Elevated (n=98)Stable low(n=58)Norma-lized (n=34)Elevated (n=126)Stable low (n=78)Norma-lized(n=40)Elevated (n=81)ParameterAge (years)43.7 (12.1)38.9 (10.9)42.7 (12.0)50.4 (13.3)46.1 (13.8)45.7 (12.5)44.0 (12.8)37.2 (14.6)38.7 (12.8)Male gender, n (%)63 (79.7)71.0 (88.8)78 (79.6)39.0 (67.2)30 (88.2)109 (86.5)35 (44.9)23 (57.5)34 (42)Duration of symptoms since axSpA onset (years)17.5 (11.2)14.4 (9.3)16.1 (9.9)21.7 (12.9)16.8 (11.6)18.9 (10.9)12.1 (9.9)10.3 (9.7)9.5 (9.0)HLA-B27 positive, n (%)69 (87.3)75.0 (93.8)89 (90.8)31.0 (91.2)101 (80.2)101 (80.2)48 (61.5)31 (77.5)67 (82.7)BASDAI Total Score6.5 (1.4)6.7 (1.5)7.0 (1.1)7.4 (1.5)7.3 (1.3)7.4 (1.3)6.9 (1.5)7.1 (1.6)7.2 (1.5)ASDAS Total Score3.1 (0.5)3.9 (0.6)4.2 (0.7)3.5 (0.6)4.3 (0.6)4.4 (0.8)3.2 (0.6)4.2 (0.8)4.2 (0.9)Spinal Pain due to AS7.0 (1.5)7.0 (1.5)7.5 (1.3)7.8 (1.5)7.7 (1.5)7.9 (1.4)7.2 (1.7)7.5 (1.7)7.5 (1.6)Patients with peripheral articular manifestations (>=1 TJC or >=1 SJC)47 (59.5)40 (50)62 (63.3)43 (74.1)24 (70.6)86 (68.3)56 (71.8)33 (82.5)66 (81.5)MRI Spine SPARCC ScoreMRI SIJ SPARCC ScoreMRI SPARCC Score6.7 (11.2)21.8 (27.3)20.7 (25.7)1.2 (2.3)7.0 (7.6)10.4 (17.0)5.2 (6.6)6.1 (8.2)6.2 (10.5)Conclusion:IXE reduced clinical disease activity in patients with axSpA irrespective of hsCRP change from BL to wk 16. Improvement in hsCRP level was associated with overall response rates.Acknowledgements:The authors would like to acknowledge Philana Fernandes, an employee of Eli Lilly and Company, for her for writing and editorial support.Disclosure of Interests:Helena Marzo-Ortega Consultant of: Celgene, Janssen, Eli Lilly, Novartis, Pfizer, UCB, Grant/research support from: Janssen, Novartis, Xavier Juanola: None declared, Tadashi Okano Speakers bureau: Asahi Kasei, Astellas, Abbvie, Ayumi, Chugai, Daiichi-Sankyo, Eisai, Eli Lilly, Janssen, Mitsubishi Tanabe, Novartis, Ono, Pfizer, Sanofi and Takeda, Grant/research support from: Asahi Kasei, Abbvie, Chugai, Eisai, Yves Schymura Employee of: Eli Lilly, Andrew Bradley Shareholder of: Eli Lilly, Employee of: Eli Lilly, Jens Gerwien Shareholder of: Eli Lilly, Employee of: Eli Lilly, Brigitte Monsberger Shareholder of: Eli Lilly, Employee of: Eli Lilly, Soyi Liu Leage Employee of: Eli Lilly, Daniel Aletaha Speakers bureau: Abbvie, Amgen, Celgene, Lilly, Medac, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi/Genzyme, Grant/research support from: Abbvie, Lilly, Novartis, Roche, Mikkel Østergaard Speakers bureau: Abbvie, Celgene, Eli-Lilly, Janssen, Novartis, Pfizer, Roche, Sanofi and UCB, Consultant of: Abbvie, BMS, Boehringer-Ingelheim, Celgene, Eli-Lilly, Hospira, Janssen, Merck, Novartis, Novo, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi and UCB, Grant/research support from: Abbvie, BMS, Merck, Celgene, Novartis

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Narayanan, Govindarajan. "Probabilistic fatigue model for cast alloys of aero engine applications." International Journal of Structural Integrity ahead-of-print, ahead-of-print (July 21, 2020). http://dx.doi.org/10.1108/ijsi-05-2020-0048.

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PurposeThe purpose of this study is to address the complexity involved in computing the fatigue life of casted structure with porosity effects in aero engine applications. The uncertainty of porosity defects is addressed by introducing probabilistic models.Design/methodology/approachOne major issue of casted aluminium alloys in the application of aerospace industries is their internal defects such as porosities, which are directly affecting the fatigue life. Since there is huge cost and time effort involved in understanding the effect of fatigue life in terms of the presence of the internal defects, a probabilistic fatigue model approach is applied in order to define the realistic fatigue limit of the casted structures for the known porosity fractions. This paper describes the probabilistic technique to casted structures with measured porosity fractions and its relation to their fatigue life. The predicted fatigue life for various porosity fractions and dendrite arm spacing values is very well matching with the experimentally predicted fatigue data of the casted AS7G06 aluminium alloys with measured internal defects. The probabilistic analysis approach not only predicts the fatigue life limit of the structure but also provides the limit of fatigue life for the known porosity values of any casted aluminium bearing support structure used in aero engines.FindingsThe probabilistic fatigue model for addressing porosity in casting structure is verified with experimental results.Research limitations/implicationsThis is grey area in aerospace and automotive industry.Originality/valueThis work is original and not published anywhere else.

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Saxena, Medha Mani, and Ruchi Saxena. "A CROSS SECTION STUDY ON IRON DEFICIENCY ANEMIA IN ADOLESCENT GIRLS." International Journal of Medical and Biomedical Studies 5, no. 4 (April 10, 2021). http://dx.doi.org/10.32553/ijmbs.v5i4.1860.

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Background: Iron deficiency is the most common cause of anemia and is one of the leading risk factors for disability and death worldwide, affecting an estimated 2 billion people Methods: This was cross-sectional study. All the adolescent girls who were given consent to hemoglobin estimation were included in the study. Results: The prevalence of anemia among adolescent girls was found as73.6%. Out of 736 anemic girls, 536 girls were suffering from mild degree of anemia and 173 girls were having moderate degree of anemia. Only 27 girl was found severely anemic. Conclusion: The prevalence of anemia among adolescent girls is alarmingly high in India. Keywords: Prevalence, Anemia, Adolescent.

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Inglis, G. Douglas, Jenny F. Gusse, Kathaleen E. House, Tara G. Shelton, and Eduardo N. Taboada. "Clinically Relevant Campylobacter jejuni Subtypes Are Readily Found and Transmitted within the Cattle Production Continuum but Present a Limited Foodborne Risk." Applied and Environmental Microbiology 86, no. 6 (December 20, 2019). http://dx.doi.org/10.1128/aem.02101-19.

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ABSTRACT Increasing evidence exists for the role that cattle play in the epidemiology of campylobacteriosis. In this study, the prevalence and distribution of Campylobacter jejuni were longitudinally examined at the subspecies level in the beef cattle production continuum. Animals were subdivided into two groups: those that were not administered antibiotics and those that were administered the antimicrobial growth promoter chlortetracycline and sulfamethazine (AS700). Samples were longitudinally collected throughout the confined feeding operation (CFO) period and during the slaughter process, and C. jejuni was isolated and genotyped to assess subtype richness and to elucidate transmission dynamics from farm to fork. The bacterium was frequently isolated from cattle, and the bacterial densities shed in feces increased over the CFO period. Campylobacter jejuni was also isolated from digesta, hides, the abattoir environment, and carcasses. The administration of AS700 did not conspicuously reduce the C. jejuni densities in feces or within the intestine but significantly reduced the bacterial densities and the diversity of subtypes on abattoir samples. All cattle carried multiple subtypes, including clinically relevant subtypes known to represent a risk to human health. Instances of intra-animal longitudinal transmission were observed. Although clinically relevant subtypes were transmitted to carcasses via direct contact and aerosols, the bacterium could not be isolated nor could its DNA be detected in ground beef regardless of treatment. Although the evidence indicated that beef cattle represent a significant reservoir for C. jejuni, including high-risk subtypes strongly associated with the bovine host, they do not appear to represent a significant risk for direct foodborne transmission. This implicates alternate routes of human transmission. IMPORTANCE Limited information is available on the transmission of Campylobacter jejuni subtypes in the beef production continuum and the foodborne risk posed to humans. Cattle were colonized by diverse subtypes of C. jejuni, and the densities of the bacterium shed in feces increased during the confined feeding period. Campylobacter jejuni was readily associated with the digesta, feces, and hides of cattle entering the abattoir, as well as the local environment. Moreover, C. jejuni cells were deposited on carcasses via direct contact and aerosols, but the bacterium was not detected in the ground beef generated from contaminated carcasses. We conclude that C. jejuni bacterial cells associated with beef cattle do not represent a significant risk through food consumption and suggest that clinically relevant subtypes are transmitted through alternate routes of exposure.

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Ge, Z., T. Eronen, A. de Roubin, J. Kostensalo, J. Suhonen, D. A. Nesterenko, O. Beliuskina, et al. "Direct determination of the atomic mass difference of the pairs As76−Se76 and Tb155−Gd155 rules out As76 and Tb155 as possible candidates for electron (anti)neutrino mass measurements." Physical Review C 106, no. 1 (July 13, 2022). http://dx.doi.org/10.1103/physrevc.106.015502.

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Thornton, GD, TA Musa, M. Rigolli, M. Loudon, C. Chin, S. Pica, T. Malley, et al. "Interaction of stroke volume and myocardial phenotype in patients with severe aortic stenosis referred for intervention: outcome data from the BSCMR AS700 study." European Heart Journal - Cardiovascular Imaging 22, Supplement_1 (January 1, 2021). http://dx.doi.org/10.1093/ehjci/jeaa356.266.

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Abstract Funding Acknowledgements Type of funding sources: None. onbehalf The BSCMR Valve Consortium Background Patients with low-flow aortic stenosis (LF-AS) have higher mortality than those with high-flow severe AS. The conventional echocardiographic definition of LF-AS is an indexed stroke volume (SVi) <35ml/m2. Whether this cut-off translates to cardiac magnetic resonance (CMR), and how CMR SVi associates with myocardial remodelling (volume/function/scar) and survival is unclear. Purpose To determine the association between CMR SVi, myocardial remodelling and survival in severe symptomatic AS. Methods In a multi-centre longitudinal outcome study of patients with severe AS listed for either surgical (SAVR) or transcatheter aortic valve intervention (TAVI) at six cardiothoracic centres, survival was assessed and stratified by SVi. Patients underwent preprocedural echocardiography and CMR between January 2003 and May 2015. Standardised core-lab analyses on pre-procedural CMR for biventricular volumes, function and scar quantification were performed. All-cause and cardiovascular mortality were tracked for a minimum of two years after AVR. Results A total of 674 patients with severe AS (age 75 ± 14years; 63% male, aortic valve area 0.4 ± 0.1 cm2/m2) were included. Patients with low SVi by CMR <35ml/m2 were older and had a greater burden of comorbidities (atrial fibrillation [AF], diabetes, high BMI). Independent predictors of SVi were age, AF, increased left atrial volume, aortic valve regurgitant fraction and left ventricular mass (LV) mass index (by CMR). There was no difference in SVi with choice of intervention (TAVI vs SAVR) or presence of late gadolinium enhancement. In multivariate analysis (Table 1), SVi was associated with cardiovascular mortality in the whole cohort (HR 0.97, 95%CI 0.95-0.99, p = 0.02), and all-cause mortality after TAVI (HR 0.97, 95%CI 0.95-0.99, p = 0.006) but not SAVR (p = 0.6). Adjusted mortality hazard increases below 50ml/m2 and plateaus between 35-40ml/m2 (Figure 1A), adjusted for LGE, STS score (Society of Thoracic Surgery score) and wall thickness. Conclusion SVi by CMR is an independent predictor of cardiovascular mortality. Mortality hazard increases progressively below a SVi of 50mL/m2. Abstract Figure 1

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