Dissertations / Theses on the topic 'Arteriopathy'
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Hayashino(Miyagawa), Aya. "Arteriopathy in chronic allograft rejection in liver transplantation." Kyoto University, 2005. http://hdl.handle.net/2433/144489.
Quesada, Sabaté Miquel. "Arteriopatia perifèrica assimptomàtica: prevalença, detecció i tractament." Doctoral thesis, Universitat de Girona, 2017. http://hdl.handle.net/10803/457149.
Introducció Existeix poca informació epidemiològica de la malaltia arterial perifèrica (MAP) al nostre medi, la recomanació de cribratge amb índex turmell-braç (ITB) en individus asimptomàtics és objecte de controvèrsia i es desconeix l'efectivitat de les intervencions de reducció de risc amb estatines en pacients amb MAP asimptomàtica. Objectius Els objectius de la present tesi són: 1) Determinar la prevalença d'ITB <0,9 i de MAP asimptomàtica, la seva associació amb factors de risc cardiovascular (FRCV) en la població de 35-79 anys i estimar l'impacte d'afegir la mesura d'ITB a la predicció de risc cardiovascular 2) Desenvolupar i validar una funció de risc per seleccionar els millors candidats pel cribratge de MAP amb ITB en la població de 50-79 anys d'edat 3) Avaluar si la teràpia amb estatines s'associa a una reducció d'esdeveniments cardiovasculars (ECV) i de mortalitat en aquesta població
Joseph, Emlyn Clive. "Pathogenesis of arteriopathy induced by PDE III inhibitors in the rat and dog." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307684.
Low, Wee Chuang Roger. "Molecular pathology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and hereditary multi-infarct dementia." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417546.
Martin, Roswell James. "CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) : clinical features and approaches to genetic screening in the UK." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609947.
Cowan, Bryce John. "Elafin inhibition of fibronectin synthesis and inflammatory cell proliferation, and reduction of post-cardiac transplant coronary arteriopathy and myocardial necrosis, in vitro and in vivo mechanisms." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0003/NQ35133.pdf.
FELISATTI, Michele. "Compressione pneumatica intermittente negli stadi avanzati di arteriopatia periferica: studio delle modificazioni emodinamiche e della perfusione distale indotte da un dispositivo originale e confronto con uno strumento disponibile sul mercato." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2389232.
Ait, Hmad Zouhair. "Lp(a) et arteriopathie obliterante des membres inferieurs." Strasbourg 1, 1994. http://www.theses.fr/1994STR15001.
Lanéelle, Damien. "Hémodynamique cérébrale et périphérique dans un contexte de variation de pression de perfusion d'origine environnementale ou pathologique." Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC430.
The work presented here explore the spectral analysis of the sonogram and the impact of microgravity on cerebral hemodynamics. The reproducibility of sonogram analysis by classification is low (κ=0.522 [0.520-0.523], p<0.005 with 4 categories, κ=0.546 [0.544-0.547], p<0.001 with 13 categories) independently of the professional’s diploma or experience. The 13-category classification had a low deviance rate (5% compared with 82% to 88%). Gravitational transitions can promote a minor rupture of the blood-brain barrier (significant increase in specific biomarkers, p < 0.05). Microgravity causes a selective increase in external carotid artery blood flow ( ̇��ECA, 46%; p = 0.030) while cerebral blood flow (CBF) remains unchanged. The variations in CBF associated with hypercapnia (+29% ±18) or simulated hypovolemia (-11% ±10) and the distribution of this CBF were independent of intracranial arterial anatomy. These results encourage us to evaluate the combined effect of hypoxia and microgravity on the ̇��ECA as well as the link with the spaceflight associated neuro-ocular syndrome. The common perspective is to study the control of peripheral vascular resistance in order, on the one hand, to standardize the conditions for acquiring sonograms in the context of arteriopathy and, on the other hand, to study potential countermeasures for regulating the arterial flow in the context of gravitational physiology
Ombredane, Marie-Pierre. "L'endofibrose de l'artere iliaque externe : une arteriopathie du cycliste de competition." Angers, 1988. http://www.theses.fr/1988ANGE1080.
GOUIRAND, ROMAIN. "Arteriopathie obliterante de type moyamoya : cause d'infarctus cerebral chez 6 adultes." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20851.
PUECH, JEAN-LUC. "Osteoporose masculine et arteriopathie des membres inferieurs : etude sur 32 cas." Toulouse 3, 1991. http://www.theses.fr/1991TOU31037.
Arnoni, Renato Tambellini. "Avaliação da arteriopatia distal em pacientes com embolia pulmonar: estudo anátomo-patológico." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-20022009-135725/.
The pulmonary embolism, caused by pulmonary artery branches obstruction from thrombus originated on other parts of the body, has a high incidence. However, just 5% of the cases develop the cronification and pulmonary hypertension. Two hypotheses can explain the cronification of tromboembolic pulmonary events: 1. maintenance of occlusive factor with pulmonary vascular response characterized by medial hypertrophy; 2. pulmonary hypertensive response as an initial arteriopathy in patients with bad evolution. This study aims to evaluate histologic aspects of pulmonary arterial bed (quantitative and qualitative), and to compare the results from embolic cases with non embolic cases. The study evaluated 55 patients (31 with pulmonary embolic disease and 24 in the control group myocardium infarction). From the selected cases, the blades with pulmonary tissue were colored by two techniques (haematoxilin-eosin and Miller). The analysis encompassed qualitative (vasoconstriction and intimal proliferation) and quantitative (mensuration of medial thickness) observations. It has been observed histologic changes between the two groups with pulmonary embolic disease (chronic or acute), and the control group. The changes between the embolic groups were: 1. higher vasoconstriction in the acute group, 2. more intimal proliferation in the chronic group, 3. no difference in the quantitative response (medial thickness). The ischemic response to obstruction can perform an important role in these changes, but further studies are necessary. There was a similar response in chronic and acute cases
Forés, Raurell Rosa. "Incidència d´arteriopatia perifèrica i morbi-mortalitat cardiovascular després de 5 anys de seguiment de la cohort poblacional ARTPER." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/650852.
This thesis was designed to improve the knowledge of peripheral arterial disease epidemiology , to study the involved factors in its onset and the cardiovascular morbidity and mortality impact in our environment. After 5 years of follow - up of a population cohort aged over 49 years (ARTPER cohort), 3 related studies were conducted. The first study evaluated the incidence of peripheral arterial disease at 5 years of follow-up of the ARTPER population cohort and the factors associated with its onset. The second study evaluated the contribution of the ankle-brachial index in the reclassification of cardiovascular risk according to Framingham and REGICOR the risk scores. The third study evaluated the evolution and the degree of control of the classics cardiovascular risk factors, after 5 years of cohort monitoring and its relation to the incidence of peripheral arterial disease. The ARTPER cohort was created between October 2006 and June 2008 to study the prevalence of peripheral arterial disease recruiting 3,786 individuals > 49 years old from 24 health centers in the metropolitan area of Barcelona and the Barcelonès Nord-Maresme. Subsequently, a telephone tracking and review of the medical history was carried out every 6 months from the inclusion of the participants until 2016. Between 2011-2012 the participants were re-examined in a second face-to-face visit to evaluate the incidence of peripheral arterial disease. The participation was 77%. As a result of this thesis the following articles have been published: Alzamora MT, Forés R, Pera G, Baena-Díez JM, Heras A, Sorribes M, Valverde M, Muñoz L, Mundet X, Torán P. Incidence of peripheral arterial disease in the ARTPER population cohort after 5 years of follow-up. BMC Cardiovasc Disord. 2016; 16: 8. FI: 1,832. Q3. Forés R, Alzamora MT, Pera G, Baena-Díez JM, Mundet-Tuduri X, Torán P. Contribution of the ankle-brachial index to improve the prediction of coronary risk: the ARTPER cohort. PLoS One. 2018; 13(1): e0191283. FI: 2,806 Q1. Forés R, Alzamora MT, Pera G, Valverde M, Angla M, Baena-Díez JM, Mundet-Tuduri X. Evolución y grado de control de los factores de riesgo cardiovascular tras 5 años de seguimiento y su relación con la incidencia de arteriopatía periférica: cohorte poblacional ARTPER. Med Clin (Barc). 2017;148(3):107–113. FI: 1,125. Q3. Concusions: The peripheral arterial disease incidence in the ARTPER cohort after 5 years of follow-up was 8.6 cases / 1,000 person-years. In people <65 years old, it is higher in men, equaling> 75 years in both sexes. Smoking, age and limitation for physical exercise are the associated factors with decreased ankle-brachial index and the appearance of peripheral arterial disease. Adding the ankle-brachial index to the REGICOR score improves the reclassification at high risk cardiovascular about 7%. An ankle-brachial index <0.9 is associated with a higher incidence of coronary and cerebrovascular events in the population cohort, with low cardiovascular risk, ARTPER. The classic cardiovascular risk factors prevalence and its treatment increase after 5 years of follow-up, but only optimal control is achieved in 7% of patients. Poorly controlled hypertension doubles the risk of having peripheral arterial disease and smoking fivefold.
Bascou-Bussac, Mylène. "Comparaison des effets hemodynamiques de l'etomidate et du thiopental a l'induction anesthesique chez le sujet age arteriopathe." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20827.
LEMBERTHE, THIERRY. "Les arteriopathies tronculaires de la femme jeune." Lyon 1, 1988. http://www.theses.fr/1988LYO1M291.
NIQUET, LEFEVRE YASMINE. "Les complications vasculaires apres les radiotherapies." Amiens, 1990. http://www.theses.fr/1990AMIEM007.
Linke, Kristina. "Idiopathische Arteriopathia calcificans (iAc) bei operierten Patienten mit therapieresistenter Epilepsie unter Berücksichtigung der Literatur." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968415911.
Junqueira, Paulo Alves. "Arteriopatia do tipo moyamoya na Sindrome de Down : estudo clinico-epdemiologico atraves de metanalise." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311125.
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A coexistência de pacientes com diagnóstico de síndrome de Down e anormalidades cerebrovasculares semelhantes às detectadas na doença de moyamoya (fenômeno moyamoya) têm sido sistematicamente relatadas nos últimos 20 anos. FUKUSHIMA et a! (1986) encontraram esta associação em um entre 532 pacientes com síndrome de Down e NISHIMURA et al (1985) um entre 400. Segundo KAWAI (1985 ) estes dados são três vezes superiores a incidência da doença de moyamoya na população geral. Este trabalho tem como objetivo estudar o caso de duas crianças com diagnóstico de síndrome de Down que apresentaram quadro vascular isquêmico agudo, atendidas na disciplina de Neurologia Infantil da FCM-UNICAMP e rever a literatura pertinente a este tema. Realizou-se avaliação clínico-neuro lógica e estudo por imagem dos pacientes, bem como metanálise de todos os casos desta associação descrita na literatura no período compreendido entre 1977 a 2000. Foram encontrados 40 relatos de casos, resumidos na Tabela 1, acrescidos de dois casos pessoais. Nove casos ocorreram em lactentes (até dois anos de idade). 19 em pré-escolares (dois - seis anos), seis em escolares (sete - 12 anos) cinco em adolescentes (13-19 anos) e apenas três em adultos (acima dos 20 anos). A relação entre sexo masculino/feminino foi de 1:1,33. Foi constatado ataque isquêmico transitório [AIT] em sete pacientes (16,6%); infarto em 32 (76,2%) e episódio hemorrágico somente em três (7,2%). A idade de início dos sinais e sintomas variou de seis meses a 27 anos, com pico de incidência ocorrendo entre um e seis anos. Os pacientes catalogados na metanálise são oriundos de 12 diferentes países, sendo 13 originários do Japão. Hemiparesia foi o sintoma clínico inaugural em 33 casos (78,5%), seguidos por distúrbios da feia em 11 casos (26,2%), convulsões em seis casos (14,3%) e, numa incidência menor em ordem decrescente de freqüência, movimentos involuntários (coréia), fraqueza muscular, paralisia facial, cefaléia, atrofia óptica e cegueira cortical nos demais casos. Em 24 pacientes por ocasião do diagnóstico encontrava-se presente apenas um distúrbio neurológico, em 15 pacientes, dois distúrbios concomitantes e em três pacientes, três distúrbios concomitantes. O comprometimento vascular foi bilateral em 35 casos (83,3%) e unilateral em sete (16,7%). Cardiopatia esteve presente em 10 pacientes (23,8%) sendo a Comunicação Intraventricular [CIV] a mais freqüente (40%). Os episódios isquêmicos foram recorrentes em 26 pacientes (62%) e isolados em 16 (38%). Estes dados enfatizam a freqüente associação entre síndrome de Down e moyamoya, fazendo com que, diante de pacientes com síndrome de Down e episódios de hemiparesia aguda, se formalize a hipótese de quadro vascular isquêmico com a inclusão da síndrome de moyamoya no diagnóstico diferencial
Abstract: Patients diagnosed with Down syndrome and cerebrovascular abnormalities similar to those detected in moyamoya disease (moyamoya phenomenum) have been systematically described in the last 20 years. FUKUSHIMA et al (1986) found this association in one of 532 Down Syndrome patients, and NISHIMURA et al (1985) found one in 400. According to KAWAI(1985), these figures are three fold the incidence of moyamoya disease in the general population. This paper has the goal of studying two children diagnosed with Down syndrome who presented with an acute ischemic vascular condition, and were cared for at the Child Neurology Department of FMC - UN1CAMP, and reviewing the literature pertaining to this theme. The patients were clinically and neuro logically evaluated, imaging tests were performed and a meta-analysis was conducted including all the cases in the literature presenting the above association in the period of 1977 to 2000. Forty cases reports were found and are summarized in Table 1, plus two cases seen by the author. Nine were infants (up to two years of age ), nineteen pre-schoolers (2-6 years of age), six children in school age (7-12 years of age), five teen-agers (13-19 years of age) and only three adults (over 20 years of age). The gender ratio was 1:1.33 (male/female ratio). With regard to the disease subtype, the transient ischemic attack (TIA) type was reported in 7 patients (16,6%), the infarction type in 32 (76,2%), and the hemorrhagic type in 3 (7,2 %). The age of onset of signs and symptoms ranged from six months to 27 years of age, with a peak incidence occurring between one and six years . The patients included in the meta-analysis came from 12 different countries, and of the total 13 came from Japan. Hemiparesis was initial clinical symptom in 33 cases (78,5%), followed by speech disorders in II cases (26,2%), seizures in 6 cases (14,3%), and, with a lower incidence, from most to less frequent, involuntary movements (chorea), muscle weakness, facial paralysis, headache, optical atrophy and cortical blindness in the remaining cases. In 24 patients, at the time of diagnosis, there was only one neurological disorder present; in 15 patients, two concurrent disorders; and in 3 patients, three concurrent disorders. Vascular involvement was bilateral in 35 cases (83.3%) and unilateral in 7 cases (16.7%). Congenital heart detects were present in 10 patients (23.8%), and among those, ventricular septal defect (VSD) was the most frequent condition (40%). Ischemic episodes were recurrent in 26 patients (62%) and isolated in 16 (38%). These data highlight the frequent association between Down syndrome and moyamoya disease, so that, when faced with Down syndrome patients with acute hemiparesis episodes, the hypothesis should be raised of an ischemic vascular condition including moyamoya syndrome in the differential diagnosis
Mestrado
Neurologia
Mestre em Ciências Médicas
Velescu, Alina. "Arteriopatía obliterante de extremidades inferiores en una población Mediterránea: epidemiología y asociación con enfermedad cardiovascular." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405306.
INTRODUCTION: Peripheral arterial disease (PAD) is one of the three main clinical manifestations of atherosclerosis. PAD is the leading cause of limb loss in western countries and an independent risk factor for coronary and cerebrovascular events, and all cause mortality. OBJECTIVES: 1. To determine the incidence and risk factors of PAD in the Mediterranean population. 2. Evaluate the association between PAD and the incidence of other forms of cardiovascular disease. If there is an association, evaluate whether the inclusion of ankle-brachial index (ABI) in cardiovascular risk functions improves its predictive capacity. 3. To evaluate the association between a high ABI and the incidence of other forms of cardiovascular disease. Characterize the profile of individuals with abnormally high ABI. METHODOLOGY: Prospective population-based cohort of 6352 subjects living in Girona, aged between 35 and 79 years, evaluated between 2004-2006 and followed up to 2012, which is part of the REGICOR study (Girona Registry from the heart). Baseline variables included baseline cardiovascular risk factors, history of coronary and cerebrovascular disease, and ABI measurement. All participants were invited to attend a second physical examination between 2009-2012. At this follow-up visit, classic cardiovascular risk factors and other comorbidities were measured again, and second ABI measurement was performed. During follow-up all incident coronary and cerebrovascular events and mortality were recorded. RESULTS: Objective 1: The cumulative incidence rate of PAD in the population was 377 / 100,000 person-years-1. The incidence rate of asymptomatic PAD was almost three times higher than that of symptomatic PAD. The incidence rate of PAD increased with age, with a marked increase from 65 years and was higher in men than in women. Uncontrolled diabetes mellitus was the most potent risk factor for the development of PAD (OR=10.14). In participants of 65 years or less, diabetes and systolic blood pressure (SBP) were associated with the incidence of PAD, while in those older than 65 years; the variables with the greatest association were tobacco and SBP. Objective 2: PAD was associated with an increased risk of coronary and cardiovascular disease in general (HR=2.08 and HR=2.24, respectively). The inclusion of ABI in the Framingham-REGICOR function improved both discrimination and its ability to reclassify cardiovascular events. The increment of the C statistic for cardiovascular events was 0.007 and the net improvement of the reclassification (NRI) was 0.029. Objective 3: An ITB≥1.4 was not associated with a higher incidence of CV events, but with all-cause mortality (HR=1.97) and CV mortality (HR=3.30). The profile of individuals with abnormally high ABI revealed the following independent factors: age, male sex, diabetes and high diastolic blood pressure CONCLUSIONS: The incidence of PAD in our study was lower than in other developed countries. Diabetes is the most important risk factor in individuals younger than 65 years, while smoking is the most relevant in people over 65 years. Long term uncontrolled diabetes is the main risk factor for PAD incidence. PAD is strongly associated with the incidence of coronary and cardiovascular events in general. The inclusion of ABI in the Framingham-REGICOR risk function improves its predictive capacity for cardiovascular events. Subjects with abnormally high ABI do not present a higher rate of cardiovascular events. However, they do show a clear association with cardiovascular and total mortality, so they can be considered as a high-risk population.
PADOVANI, MICHEL. "Les pontages jambiers pour arteriopathie chronique obliterante des membres inferieurs : a propos de 73 cas." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20172.
ECKSTEIN, ULRICH JOHANNES. "L'angioscopie arterielle peripherique par voie percutanee : interet diagnostique et therapeutique ; a propos de 111 patients." Lille 2, 1990. http://www.theses.fr/1990LIL2M124.
CONCHONNET, PHILIPPE. "Arteriopathies de la femme : a propos d'une etude prospective comparative entre les sexes." Saint-Etienne, 1989. http://www.theses.fr/1989STET6401.
CATTEAU, TREHAUT NATHALIE. "Arteriopathies symptomatiques du membre superieur : a propos de 66 observations." Lille 2, 1993. http://www.theses.fr/1993LIL2M338.
MILLION-RANQUIN, MARTIAL. "Pontages composites sous le genou : resultats a propos de 83 cas." Lyon 1, 1989. http://www.theses.fr/1989LYO1M209.
Bosnardo, Carla Aparecida Faccio. "Avaliação clinica de doentes hipercolesterolemicos e arteriopatas apos tratamento medico com base na qualidade de vida." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310512.
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A ateroesclerose atinge cerca de 10% da população mundial e é uma das principais causas de morte ou incapacidade física nos países desenvolvidos; inúmeros tratamentos médicos vem sendo propostos para o seu controle e de suas complicações como a doença oc1usiva crônica dos membros inferiores. No período de maio a dezembro de 1999, foram acompanhados trinta doentes, divididos em três grupos distintos de maneira aleatória, sendo 19 homens (63.3%) e 11mulheres (36,6%) com idade média de 59.9 anos; todos arteriopatas e claudicantes. Cada grupo recebeu um tipo de tratamento distinto:grupo I dieta hipocolesterolêmica e fisioterapia programada, grupoII dieta normocolesterolêmica, fisioterapia programada e Sinvastatina na dose diária de 10mg e grupo III dieta livre, fisioterapia programada e Sinvastatina na dose diária de 10mg. A cada doente foram aplicados questionários relacionados a qualidade de vida, cuja a conclusão foi que o grupo II é o que melhor responde e é o que tem melhor qualidade de vida ao final do tratamento
Abstract: Since atheroesclerosis hits around 10% of the world population and is one of the major causes of death or physical disability in developed countries, endless treatments have been proposed for its control as well as for the treatment of its further complications, such as the chronic occlusive disease of the lower members. The present study was conducted taking this into account. In the period ofMay to December 1999, thirty patients19 men (63,3%) and 11 women (36,6%) of an average age of 59,9 years - were followed up. They were randomly divided into three groups. All patients were arteriopatas and limping. Each group received a different kind of treatment: the first one was treated with a hipocolesterolemic diet and programmed physiotherapy; the second with a normocolesterolemic diet, programmed physiotherapy and a daily dose of 10 mg of Sinvastatine and the third with a ffee diet, programmed physiotherapy and a daily dose of 10 mg of Sinvastatine. A questionnaire about the qua1ity of life was given to each patient, the conc1usion being that the second group was the one with the best response to its treatment, having the greatest improvement regarding quality of life
Mestrado
Cirurgia
Mestre em Cirurgia
RAILLAT, CHRISTOPHE. "Endoprotheses vasculaires auto-expansives et arteriopathie obliterante des membres inferieurs : resultats preliminaires de 50 premiers cas." Toulouse 3, 1988. http://www.theses.fr/1988TOU31146.
Valverde, Peris Marta. "Eventos vasculares tras 9 años de seguimiento en una cohorte poblacional mediterránea (Estudio ARTPER)." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669951.
Spanish population is considered a low cardiovascular risk population although vascular events are the principal cause of death. Coronary events were ranked as the first in number of deaths in the general population, followed by cerebrovascular events. Objective: the aim of our study is to determine the incidence of vascular events in lowcardiovascular-risk general population after 9 years follow-up, as well as the influence of vascular risk factors, with a special interest in peripheral arterial disease patients and future events. Methods: ARTPER is an ongoing prospective observational population cohort study with 3786 subjects over 49 years old recruited (simple random sampling) from Primary Health Care Centers. We obtained demographic variables, different vascular risk scores, the presence of principal cardiovascular risk factors (hypertension, diabetes mellitus, hypercholesterolemia, smoking habit, obesity, abdominal obesity and peripheral arterial disease). Vascular events or morbi-mortality (vascular and non-vascular cause) were classified as end points. Results: Patient with peripheral arterial disease present higher incidence of vascular events. The risk of vascular mortality is up to 7 times higher in individuals with peripheral arterial disease than healthy population. The risk of coronary events and cerebrovascular events is greater than 4 times and 3 times respectively in subjects with peripheral arterial disease in contrast with healthy population. Subjects with arterial calcification do not present differences in the incidence of vascular events compared to healthy subjects, except in cerebrovascular events. The recurrence of vascular events independently of etiology is greater in in peripheral arterial disease (42%) compared to healthy group (31%). The Odds Ratio of recurrence of cerebrovascular events for patients with peripheral arterial disease vs healthy patients after adjusting for cardiovascular risk factor is 1.77. Conclusions: The presence of peripheral arterial disease increases the incidence of vascular evens independently of other vascular risk factors, as well as the risk of recurrence, especially in cerebrovascular events.
CHEN, TI PHOON. "Implication des lipides dans les arteriopathies des membres inferieurs." Clermont-Ferrand 1, 1994. http://www.theses.fr/1994CLF1M038.
DECLEMY, SERGE. "L'arteriopathie chronique obliterante des membres inferieurs du sujet jeune de moins de 40 ans." Nice, 1990. http://www.theses.fr/1990NICE6819.
FAUCHEUX, JEAN-MARC. "La neuropathie liee a l'arteriopathie chronique des membres inferieurs : realite clinique et consequences." Toulouse 3, 1994. http://www.theses.fr/1994TOU31508.
DEBUSE, QUATANNENS ANNE-SOPHIE. "Interet de la neuro-stimulation cordonale posterieure cervicale dans le traitement des arteriopathies digitales." Lille 2, 1989. http://www.theses.fr/1989LIL2M422.
Descamps-Pirot, Marie-José. "Interet de l'oxymetrie transcutanee statique pour la determination du niveau d'amputation chez l'arteritique : etude preliminaire." Lille 2, 1990. http://www.theses.fr/1990LIL2M079.
SOUILLART, DENIS. "Amputes arteritiques : le resultat fonctionnel justifie-t-il l'appareillage ?" Lille 2, 1988. http://www.theses.fr/1988LIL2M288.
Desmyttere, Jacques, and CHRISTOPHE GRARD. "Interet de l'oxymetrie transcutanee dynamique etagee chez le claudicant : etude preliminaire." Lille 2, 1988. http://www.theses.fr/1988LIL2M324.
Fratta, Leila Xavier Sinigaglia. "Arteriopatia na atresia biliar : papel dos fatores induzidos por hipóxia e sua relação com prognóstico pós-portoenterostomia." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/116798.
Background: Biliary atresia (BA) includes a complete obstruction of the extrahepatic biliary tract and progressive intrahepatic cholangiopathy, and the nature of these processes remains unclear. An arteriopthy, leading to an ischemic cholangiopathy, can be involved. The immunolocalization of vascular endothelial growth factor A (VEGFA) in arterial branches and bile ducts both within the liver and at porta hepatis from patients with BA suggests ischemia in these structures. The occurrence of hypoxia in the hepatobiliary system in BA needs to be elucidated. Aim: To determinate the presence of hypoxia in the livers from patients with BA, by analyzing the gene expression of hypoxia-inducible factor (HIF) -1α and -2α. Methods: Liver biopsy specimens collected at exploratory laparotomy of age-matched patients with isolated, cytomegalovirus IgM-negative BA (n=32) and intrahepatic cholestasis (IHC, n=9) were evaluated. A sample was ultrafrozen (molecular analysis) and the other was paraffin-embedded (for histological and morphometric analyzes). Gene expression of: HIF-1α, HIF-2α, monocyte chemoattractant protein 1 (MCP1) (biliary fibrosis marker) and cytokeratin 19 (CK19) (cholangiocyte marker) were evaluated by PCRq using TaqMan® probes. The normalizing gene was 18S ribosomal. The extents of fibrosis and ductular reaction were assessed by morphometry. Clinical and laboratory data were prospectively collected. Results: There was higher HIF-1α and HIF-2α expression in BA in comparison with IHC. In BA, the HIF-1α expression was positively correlated with total serum bilirubin (TB). Two groups were observable in BA regarding HIFs: higher (hiHIF, considering as cutoff point a value higher than 3x the median of expression in IHC) and lower (loHIF). Patients with hiHIF-1α were older and presented increased levels of TB and direct-reacting serum bilirubin (DB) than loHIF-1α. Patients with hiHIF-2α presented CK19 expression lower than in loHIF-2α. The other variables were similar in subgroups HIFs. Conclusion: In BA there is hypoxia in the liver tissue, which seems to be progressive and associated with the disappearance of bile ducts and worsening biliary obstruction.
Pérez, Ramírez Paulina. "Influencia de la anemia y el tratamiento con cilostazol en el pronóstico de los pacientes con arteriopatía periférica." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/377766.
Introduction: Peripheral artery disease (PAD) is one of the symptoms of arteriosclerosis out of coronary or cerebral arteries. PAD has been widely studied and it is considered as an indicator of cardiovascular risk, especially for coronariopaty and cerebrovascular disease. It is usually asymptomatic and when symptomatic it is commonly in form of intermittent claudication. Objectives: In this work we present two articles where the influence of anemia in the prognosis on outpatients with symptomatic PAD and the influence of the treatment with cilostazol, pharmacological treatment of intermittent claudication, and its risk for subsequent ischemic events, myocardial infarction, bleeding or death. Patients and Methods: We have used data from the FRENA Registry, a prospective registry of patients with PAD with mean follow up of 18 months. We collect data from clinical characteristics, pharmacological treatment, cardiovascular events, bleeding or death during this period. Results: Of 1663 patients with PAD, 208 (12.5%) had anemia. Over 18 months, patients with anemia had a higher rate of myocardial infarction (RR 2.10; 95% Confidence interval (CI): 1.04-3.99), limb amputation (RR: 2.98; 95% CI: 1.70-5.05), mortality (RR: 3.58; 95% CI: 2.39-5.28), with similar results for ischemic stroke and major bleeding. On multivariate analysis, anemia was associated with an increased risk to die. Of 1317 patients with intermittent claudication those who received cilostazol (14.5%) had no significant differences in the rate of subsequent ischemic events, major bleeding or death than those without cilostazol. Conclusions: In stable outpatients with PAD, anemia was associated with increased mortality but not with an increased rate of subsequent ischemic events or major bleeding. In stable outpatients with intermittent claudication, the use of cilostazol was not associated with increased rates of subsequent ischemic events, major bleeding or death.
Puisieux, François. "Anticorps antiphospholipides et arteriopathie obliterante des membres inferieurs : etude prospective cas-temoins de fevrier 1993 a janvier 1994." Lille 2, 1994. http://www.theses.fr/1994LIL2M084.
CHAPOU, MURIEL. "Depistage des cardiopathies ischemiques silencieuses chez l'arteritique : pronostic a 5 ans chez 418 patients." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF13011.
MARCO, THIERRY. "Fibrinolyse loco-regionale par urokinase dans le traitement des arteriopathies des membres inferieurs : resultats a court et long terme de 33 procedures sur arteres natives." Lyon 1, 1993. http://www.theses.fr/1993LYO1M071.
LINA, PASCAL. "Arteriopathie des membres inferieurs : interet pronostique de la tc po2 au stade d'ischemie permanente chronique ; a propos de 83 cas." Reims, 1990. http://www.theses.fr/1990REIMM011.
MULLER, CHRISTIAN. "Pontages veineux in situ femoro-poplites et femoro-jambiers : techniques et resultats a propos de 122 cas." Nancy 1, 1990. http://www.theses.fr/1990NAN11119.
SACAREAU, DIDIER. "Evaluation hemodynamique des resultats de la radiologie interventionnelle dans l'arteriopathie des membres inferieurs." Toulouse 3, 1991. http://www.theses.fr/1991TOU31040.
Jézéquel, Laurent. "Proposition de programmes rationalises de reeducation fonctionnelle dans l'arteriopathie des membres inferieurs a l'exception des amputes." Rennes 1, 1993. http://www.theses.fr/1993REN1M126.
ALAPETITE, HERVE. "Arteriopathie des membres inferieurs et medecine de reeducation : bilan, traitements et resultats du suivi a un an et plus." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20044.
NICOLAS, DUMANGE MICHELE. "L'ampute arteritique : interet de la medecine de reeducation en centre specialise pour un meilleur devenir fonctionnel et medico-social." Amiens, 1990. http://www.theses.fr/1990AMIEM005.
Leygue, G. "Indications et resultats de la sympathectomie chimique lombaire sous controle tomodensitometrique dans le traitement de l'arteriopathie des membres inferieurs." Toulouse 3, 1990. http://www.theses.fr/1990TOU31085.
GUILHEM, CANTALA NATHALIE. "Etude preliminaire a la realisation d'un systeme expert dans l'arteriopathie des membres inferieurs." Toulouse 3, 1990. http://www.theses.fr/1990TOU31248.
GILLARD, CHRISTOPHE. "La sympatholyse lombaire sous controle tomodensitometrique dans l'arteriopathie des membres inferieurs : etude retrospective de 132 procedures et revue de la litterature." Besançon, 1991. http://www.theses.fr/1991BESA3066.
ELHARAR, BERGO CORINNE. "Arteres incompressibles chez le diabetique : interet de la debitmetrie electromagnetique non sanglante." Toulouse 3, 1991. http://www.theses.fr/1991TOU31010.