Log in

Relevant bibliographies by topics / Arl15 / Journal articles

To see the other types of publications on this topic, follow the link: Arl15.

Journal articles on the topic 'Arl15'

Author: Grafiati

Published: 6 September 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Arl15.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Brito, Cheila, Bruno Costa-Silva, Duarte C. Barral, and Marta Pojo. "Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis." International Journal of Molecular Sciences 22, no. 17 (2021): 9260. http://dx.doi.org/10.3390/ijms22179260.

Full text

Abstract:

Cutaneous melanoma (CM) is the deadliest skin cancer, whose molecular pathways underlying its malignancy remain unclear. Therefore, new information to guide evidence-based clinical decisions is required. Adenosine diphosphate (ADP)-ribosylation factor-like (ARL) proteins are membrane trafficking regulators whose biological relevance in CM is undetermined. Here, we investigated ARL expression and its impact on CM prognosis and immune microenvironment through integrated bioinformatics analysis. Our study found that all 22 ARLs are differentially expressed in CM. Specifically, ARL1 and ARL11 are

APA, Harvard, Vancouver, ISO, and other styles

2

Corre, Tanguy, Francisco J. Arjona, Caroline Hayward, et al. "Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes." Journal of the American Society of Nephrology 29, no. 1 (2017): 335–48. http://dx.doi.org/10.1681/asn.2017030267.

Full text

Abstract:

Magnesium (Mg2+) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg2+, which is crucial for Mg2+ homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg2+ homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4×10−13) near TRPM6, which encodes an epithelial Mg2+ channel, and rs35929 (P=2.1×10−11), a variant of ARL15, which encodes a GT

APA, Harvard, Vancouver, ISO, and other styles

3

Zolotarov, Yevgen, Chao Ma, Irene González-Recio, et al. "ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs." Cellular and Molecular Life Sciences 78, no. 13 (2021): 5427–45. http://dx.doi.org/10.1007/s00018-021-03832-8.

Full text

Abstract:

AbstractCyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation factor-like GTPase 15 (ARL15), a small GTP-binding protein. ARL15 interacts with CNNMs at their carboxyl-terminal conserved cystathionine-β-synthase (CBS) domains. In silico modeling of the interaction between CNNM2 and ARL15 supports that the small GTPase specifically binds the CBS1 and CNBH domains. Immunocytochemical experiments demonstrate that CNNM2 and ARL15 co-lo

APA, Harvard, Vancouver, ISO, and other styles

4

Li, Yiping, Ying Yang, Yueting Yao, et al. "Association Study of ARL15 and CDH13 with T2DM in a Han Chinese Population." International Journal of Medical Sciences 11, no. 5 (2014): 522–27. http://dx.doi.org/10.7150/ijms.8206.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

de Baaij, Jeroen H. F., Yevgen Zolotarov, Chao Ma, Gijs Franken, Michel L. Tremblay, and Joost Hoenderop. "ARL15 Regulates CNNM2‐dependent Mg 2+ Transport by Modulating its N‐linked Glycosylation." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.06380.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Richards, J. Brent, Dawn Waterworth, Stephen O'Rahilly, et al. "A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels." PLoS Genetics 5, no. 12 (2009): e1000768. http://dx.doi.org/10.1371/journal.pgen.1000768.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Yang, Yong-Kang, Hong Qu, Dong Gao, et al. "ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner." Journal of Biological Chemistry 286, no. 12 (2011): 10568–80. http://dx.doi.org/10.1074/jbc.m110.206896.

Full text

Abstract:

Retinoic acid-inducible gene I (RIG-I) recognizes RNA virus-derived nucleic acids, which leads to the production of type I interferon (IFN) in most cell types. Tight regulation of RIG-I activity is important to prevent ultra-immune responses. In this study, we identified an ARF-like (ARL) family member, ARL16, as a protein that interacts with RIG-I. Overexpression of ARL16, but not its homologous proteins ARL1 and ARF1, inhibited RIG-I-mediated downstream signaling and antiviral activity. Knockdown of endogenous ARL16 by RNAi potentiated Sendai virus-induced IFN-β expression and vesicular stom

APA, Harvard, Vancouver, ISO, and other styles

8

Benabdelkamel, Hicham, Afshan Masood, Meshail Okla, Mohammed Y. Al-Naami, and Assim A. Alfadda. "A Proteomics-Based Approach Reveals Differential Regulation of Urine Proteins between Metabolically Healthy and Unhealthy Obese Patients." International Journal of Molecular Sciences 20, no. 19 (2019): 4905. http://dx.doi.org/10.3390/ijms20194905.

Full text

Abstract:

Metabolic dysfunction associated with obesity threatens to inundate health care resources by increasing the incidences of obesity-related diseases. The aim of the present study was to investigate the changes in the urinary proteome of 18 individuals classified into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) patients. Proteome analysis was performed using the two-dimensional difference in gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS). Upon analysis, a total of 54 proteins were found to be affected with ≥1.5-fold change (ANOVA, p ≤ 0.05), of wh

APA, Harvard, Vancouver, ISO, and other styles

9

Shen, Jiayi, Miao Liu, Jing Xu, Bao Sun, Heng Xu, and Wei Zhang. "ARL15 overexpression attenuates high glucose-induced impairment of insulin signaling and oxidative stress in human umbilical vein endothelial cells." Life Sciences 220 (March 2019): 127–35. http://dx.doi.org/10.1016/j.lfs.2019.01.030.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Wicky, Sidonie, Heinz Schwarz, and Birgit Singer-Krüger. "Molecular Interactions of Yeast Neo1p, an Essential Member of the Drs2 Family of Aminophospholipid Translocases, and Its Role in Membrane Trafficking within the Endomembrane System." Molecular and Cellular Biology 24, no. 17 (2004): 7402–18. http://dx.doi.org/10.1128/mcb.24.17.7402-7418.2004.

Full text

Abstract:

ABSTRACT Neo1p is an essential yeast member of the highly conserved Drs2 family of P-type ATPases with proposed aminophospholipid translocase activity. Here we present evidence that Neo1p localizes to endosomes and Golgi elements. In agreement with that finding, the temperature-sensitive neo1-37 and neo1-69 mutants exhibit defects in receptor-mediated endocytosis, vacuole biogenesis, and vacuolar protein sorting. Furthermore, neo1 mutants accumulate aberrantly shaped membranous structures most likely derived from vacuoles and the endosomal/Golgi system. At permissive temperatures, HA-Neo1-69p,

APA, Harvard, Vancouver, ISO, and other styles

11

Cui, Zhengwei, Tianxin Sheng, Yuping Wang, et al. "Association between single nucleotide polymorphisms (SNPs) in the gene of ADP-ribosylation factor-like 15 (ARL15) and type 2 diabetes (T2D) in Korean Chinese population in Yanbian, China." International Journal of Diabetes in Developing Countries 37, no. 2 (2015): 124–28. http://dx.doi.org/10.1007/s13410-015-0391-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Ishida, Morié, and Juan S. Bonifacino. "ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network." Journal of Cell Biology 218, no. 11 (2019): 3681–96. http://dx.doi.org/10.1083/jcb.201905097.

Full text

Abstract:

SNARE-mediated fusion of endosome-derived transport carriers with the trans-Golgi network (TGN) depends on the concerted action of two types of tethering factors: long coiled-coil tethers of the golgin family, and the heterotetrameric complex GARP. Whereas the golgins mediate long-distance capture of the carriers, GARP promotes assembly of the SNAREs. It remains to be determined, however, how the functions of these tethering factors are coordinated. Herein we report that the ARF-like (ARL) GTPase ARFRP1 functions upstream of two other ARL GTPases, ARL1 and ARL5, which in turn recruit golgins a

APA, Harvard, Vancouver, ISO, and other styles

13

Hsu, Jia-Wei, Pei-Hua Tang, I.-Hao Wang, et al. "Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p." Proceedings of the National Academy of Sciences 113, no. 12 (2016): E1683—E1690. http://dx.doi.org/10.1073/pnas.1518260113.

Full text

Abstract:

ADP ribosylation factor (Arf) GTPases are key regulators of membrane traffic at the Golgi complex. In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates Arf-like protein Arl1p, which was accompanied by accumulation of golgin Imh1p at late Golgi, but whether and how this function of Syt1p is regulated remains unclear. Here, we report that the inositol-requiring kinase 1 (Ire1p)-mediated unfolded protein response (UPR) modulated Arl1p activation at late Golgi. Arl1p activation was dependent on both kinase and endo-RNase activities of Ire1p. Moreover, constitutively active transc

APA, Harvard, Vancouver, ISO, and other styles

14

Liu, Ya-Wen, Chun-Fang Huang, Kai-Bin Huang, and Fang-Jen S. Lee. "Role for Gcs1p in Regulation of Arl1p atTrans-Golgi Compartments." Molecular Biology of the Cell 16, no. 9 (2005): 4024–33. http://dx.doi.org/10.1091/mbc.e05-01-0023.

Full text

Abstract:

ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins are members of the ARF family, which are critical components of several different vesicular trafficking pathways. ARFs have little or no detectable GTPase activity without the assistance of a GTPase-activating protein (GAP). Here, we demonstrate that yeast Gcs1p exhibits GAP activity toward Arl1p and Arf1p in vitro, and Arl1p can interact with Gcs1p in a GTP-dependent manner. Arl1p was observed both on trans-Golgi and in cytosol and was recruited from cytosol to membranes in a GTP-dependent manner. In gcs1 mutant cells, the fraction of

APA, Harvard, Vancouver, ISO, and other styles

15

Ishida, Morié, and Juan S. Bonifacino. "Correction: ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of tethering factors to the trans-Golgi network." Journal of Cell Biology 218, no. 11 (2019): 3880–81. http://dx.doi.org/10.1083/jcb.20190509710072019c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Xie, Ning, Qiuai Shu, Ziwei Wang, et al. "ARL11 correlates with the immunosuppression and poor prognosis in breast cancer: A comprehensive bioinformatics analysis of ARL family members." PLOS ONE 17, no. 11 (2022): e0274757. http://dx.doi.org/10.1371/journal.pone.0274757.

Full text

Abstract:

ADP-ribosylation factor-like protein (ARL) family members (ARLs) may regulate the malignant phenotypes of cancer cells. However, relevant studies on ARLs in breast cancer (BC) are limited. In this research, the expression profiles, genetic variations, and prognostic values of ARLs in BC have been systematically analyzed for the first time using various databases. We find that ARLs are significantly dysregulated in BC according to the TCGA database, which may result from DNA methylation and copy number alteration. Prognostic analysis suggests that ARL11 is the most significant prognostic indica

APA, Harvard, Vancouver, ISO, and other styles

17

Lu, Lei, and Wanjin Hong. "Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi." Molecular Biology of the Cell 14, no. 9 (2003): 3767–81. http://dx.doi.org/10.1091/mbc.e03-01-0864.

Full text

Abstract:

A cellular role and the mechanism of action for small GTPase Arl1 have been defined. Arl1-GTP interacts with the GRIP domains of Golgin-97 and Golgin-245, a process dependent on conserved residues of the GRIP domains that are important for Golgi targeting. The switch II region of Arl1 confers the specificity of this interaction. Arl1-GTP mediates Golgi recruitment of Golgin-97 in a switch II-dependent manner, whereas tethering Arl1-GTP onto endosomes can mediate endosomal targeting of Golgin-97. Golgin-97 and Golgin-245 are dissociated from the Golgi when Arl1 is knocked-down by its siRNA. Arl

APA, Harvard, Vancouver, ISO, and other styles

18

Lu, Lei, Heinz Horstmann, Cheepeng Ng, and Wanjin Hong. "Regulation of Golgi structure and function by ARF-like protein 1 (Arl1)." Journal of Cell Science 114, no. 24 (2001): 4543–55. http://dx.doi.org/10.1242/jcs.114.24.4543.

Full text

Abstract:

Arl1 is a member of the ARF-like protein (Arl) subfamily of small GTPases. Nothing is known about the function of Arl1 except for the fact that it is essential for normal development in Drosophila and that it is associated with the Golgi apparatus. In this study, we first demonstrate that Arl1 is enriched at the trans side of the Golgi, marked by AP-1. Association of Arl1 with the Golgi is saturable in intact cells and depends on N-terminal myristoylation. Over-expression of Arl1(T31N), which is expected to be restricted to the GDP-bound form and thus function as a dominant-negative mutant, ca

APA, Harvard, Vancouver, ISO, and other styles

19

Benjamin, Jeremy J. R., Pak P. Poon, John D. Drysdale, Xiangmin Wang, Richard A. Singer, and Gerald C. Johnston. "Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast." Molecular Biology of the Cell 22, no. 13 (2011): 2337–47. http://dx.doi.org/10.1091/mbc.e10-09-0765.

Full text

Abstract:

Small monomeric G proteins regulated in part by GTPase-activating proteins (GAPs) are molecular switches for several aspects of vesicular transport. The yeast Gcs1 protein is a dual-specificity GAP for ADP-ribosylation factor (Arf) and Arf-like (Arl)1 G proteins, and also has GAP-independent activities. The absence of Gcs1 imposes cold sensitivity for growth and endosomal transport; here we present evidence that dysregulated Arl1 may cause these impairments. We show that gene deletions affecting the Arl1 or Ypt6 vesicle-tethering pathways prevent Arl1 activation and membrane localization, and

APA, Harvard, Vancouver, ISO, and other styles

20

Yang, Feng, Tiantian Li, Ziqing Peng, Yang Liu, and Yusong Guo. "The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations." Journal of Biological Chemistry 295, no. 49 (2020): 16643–54. http://dx.doi.org/10.1074/jbc.ra120.014999.

Full text

Abstract:

The subcellular localization of Arf family proteins is generally thought to be determined by their corresponding guanine nucleotide exchange factors. By promoting GTP binding, guanine nucleotide exchange factors induce conformational changes of Arf proteins exposing their N-terminal amphipathic helices, which then insert into the membranes to stabilize the membrane association process. Here, we found that the N-terminal amphipathic motifs of the Golgi-localized Arf family protein, Arfrp1, and the endosome- and plasma membrane–localized Arf family protein, Arl14, play critical roles in spatial

APA, Harvard, Vancouver, ISO, and other styles

21

Rai, Amit, Vinit Raj, Ashok K. Singh, Amit K. Keshari, and Sudipta Saha. "A METHOD FOR DETERMINING 1,4-BENZOTHIAZINE DERIVATIVES IN RAT PLASMA BY HPLC AND ITS APPLICATION TO A PHARMACOKINETIC STUDY." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 12 (2017): 82. http://dx.doi.org/10.22159/ijpps.2017v9i12.19339.

Full text

Abstract:

Objective: The objective of the study was to develop, optimize and validate of a new reverse-phase high-performance liquid chromatography (RP-HPLC) method for the determining 1,4-benzothiazine derivatives (AR13 and AR15) in a biological sample of rat plasma. The 1,4-benzothiazine derivatives are produced by the synthetic reactions.Methods: RP-HPLC separation was performed using an ODS-2 Hypersil column with gradient elution mobile phase consisting of water-acetonitrile for AR13 and AR15 (1:9 v/v, 3:7 v/v) at room temperature 1 ml/min flow rate, and interfaced with photodiode array detector (PD

APA, Harvard, Vancouver, ISO, and other styles

22

Kim, Hyun Ji, Boram Kim, Hyung Jung Byun, et al. "Resolvin D1 Suppresses H2O2-Induced Senescence in Fibroblasts by Inducing Autophagy through the miR-1299/ARG2/ARL1 Axis." Antioxidants 10, no. 12 (2021): 1924. http://dx.doi.org/10.3390/antiox10121924.

Full text

Abstract:

ARG2 has been reported to inhibit autophagy in vascular endothelial cells and keratinocytes. However, studies of its mechanism of action, its role in skin fibroblasts, and the possibility of promoting autophagy and inhibiting cellular senescence through ARG2 inhibition are lacking. We induced cellular senescence in dermal fibroblasts by using H2O2. H2O2-induced fibroblast senescence was inhibited upon ARG2 knockdown and promoted upon ARG2 overexpression. The microRNA miR-1299 suppressed ARG2 expression, thereby inhibiting fibroblast senescence, and miR-1299 inhibitors promoted dermal fibroblas

APA, Harvard, Vancouver, ISO, and other styles

23

Ghislain, Noumouha, Anguété Kouamé, Bouet Alphonse, Bahan Frank, N’Guetta Simon-Pierre, and Keli Zagbahi Jules. "New drought-tolerant rainfed upland rice (Oryza sp.) genotypes adapted to the west, centre-west, and centre regions of Côte d'Ivoire." Journal of Agricultural and Crop Research 8, no. 12 (2020): 289–96. http://dx.doi.org/10.33495/jacr_v8i12.20.202.

Full text

Abstract:

To select new rainfed upland rice genotypes, adapted to the West, Centre-West, and Centre regions of Côte d'Ivoire, a study was conducted in research stations. Six genotypes (ART15-11-8-5-2-B-1, WAB891-SG12, WAB1092-B-40AB.1, ARCC3Fa3L10P1-1-B-1, and ART15-16-12 -3-1-B-1-B-3-1) including the control IDSA 10, widely cultivated across the country, were evaluated on three research stations of the National Center of Agricultural Research (CNRA), during the wet seasons of the year 2016 and 2017. These stations are located at the West, Center, and West-Center of Côte d'Ivoire. The trial was set up i

APA, Harvard, Vancouver, ISO, and other styles

24

Chen, Yan-Ting, I.-Hao Wang, Yi-Hsun Wang, et al. "Action of Arl1 GTPase and golgin Imh1 in Ypt6-independent retrograde transport from endosomes to the trans-Golgi network." Molecular Biology of the Cell 30, no. 8 (2019): 1008–19. http://dx.doi.org/10.1091/mbc.e18-09-0579.

Full text

Abstract:

The Arf and Rab/Ypt GTPases coordinately regulate membrane traffic and organelle structure by regulating vesicle formation and fusion. Ample evidence has indicated that proteins in these two families may function in parallel or complementarily; however, the manner in which Arf and Rab/Ypt proteins perform interchangeable functions remains unclear. In this study, we report that a Golgi-localized Arf, Arl1, could suppress Ypt6 dysfunction via its effector golgin, Imh1, but not via the lipid flippase Drs2. Ypt6 is critical for the retrograde transport of vesicles from endosomes to the trans-Golgi

APA, Harvard, Vancouver, ISO, and other styles

25

Scott, CF, HR Wenzel, HR Tschesche, and RW Colman. "Kinetics of inhibition of human plasma kallikrein by a site-specific modified inhibitor Arg15-aprotinin: evaluation using a microplate system and comparison with other proteases." Blood 69, no. 5 (1987): 1431–36. http://dx.doi.org/10.1182/blood.v69.5.1431.1431.

Full text

Abstract:

Abstract Human plasma kallikrein, a product of contact-activated plasma proteolysis, is moderately inhibited by aprotinin, a small polypeptide from bovine lung that has been used as an experimental drug in human disease states. Aprotinin has a Lys residue in the P1 (reactive center) position occupying residue 15. Since kallikrein is an arginine-directed serine protease, we hypothesized that an altered form of aprotinin, Arg15-aprotinin, might be a better inhibitor. Kinetic evaluations were performed in 96-well microplates. We found that the KL (loose or Michaelis-Menten complex) was unchanged

APA, Harvard, Vancouver, ISO, and other styles

26

Scott, CF, HR Wenzel, HR Tschesche, and RW Colman. "Kinetics of inhibition of human plasma kallikrein by a site-specific modified inhibitor Arg15-aprotinin: evaluation using a microplate system and comparison with other proteases." Blood 69, no. 5 (1987): 1431–36. http://dx.doi.org/10.1182/blood.v69.5.1431.bloodjournal6951431.

Full text

Abstract:

Human plasma kallikrein, a product of contact-activated plasma proteolysis, is moderately inhibited by aprotinin, a small polypeptide from bovine lung that has been used as an experimental drug in human disease states. Aprotinin has a Lys residue in the P1 (reactive center) position occupying residue 15. Since kallikrein is an arginine-directed serine protease, we hypothesized that an altered form of aprotinin, Arg15-aprotinin, might be a better inhibitor. Kinetic evaluations were performed in 96-well microplates. We found that the KL (loose or Michaelis-Menten complex) was unchanged by the mo

APA, Harvard, Vancouver, ISO, and other styles

27

Lu, Lei, Guihua Tai, and Wanjin Hong. "Autoantigen Golgin-97, an Effector of Arl1 GTPase, Participates in Traffic from the Endosome to the Trans-Golgi Network." Molecular Biology of the Cell 15, no. 10 (2004): 4426–43. http://dx.doi.org/10.1091/mbc.e03-12-0872.

Full text

Abstract:

The precise cellular function of Arl1 and its effectors, the GRIP domain Golgins, is not resolved, despite our recent understanding that Arl1 regulates the membrane recruitment of these Golgins. In this report, we describe our functional study of Golgin-97. Using a Shiga toxin B fragment (STxB)-based in vitro transport assay, we demonstrated that Golgin-97 plays a role in transport from the endosome to the trans-Golgi network (TGN). The recombinant GRIP domain of Golgin-97 as well as antibodies against Golgin-97 inhibited the transport of STxB in vitro. Membrane-associated Golgin-97, but not i

APA, Harvard, Vancouver, ISO, and other styles

28

Wang, Yueying, Mengting Qin, JinPing Liu, Xiaobo Chen, Jia Xue, and Sheng Guo. "Abstract 2053: Structural variants detected by optical genome mapping in acute lymphoblastic leukemia patient-derived xenografts models." Cancer Research 83, no. 7_Supplement (2023): 2053. http://dx.doi.org/10.1158/1538-7445.am2023-2053.

Full text

Abstract:

Abstract Background: The established classification of acute lymphoblastic leukemia (ALL) does not cover all high-risk patients because of the difficulty in detecting novel or rare structural variants (SVs). Furthermore, many SVs and formed gene fusions have adverse prognostic effects on hematological malignancies. This study aims to investigate SVs in 22 patient-derived xenografts (PDX) of ALL and to assess rare SVs and chromosomal aberrations, particularly hematological malignancy genes and gene fusions in different individuals detected by optical genome mapping (OGM). Methods: Leukemia cell

APA, Harvard, Vancouver, ISO, and other styles

29

Price, H. P., D. Goulding, and D. F. Smith. "ARL1 has an essential role in Trypanosoma brucei." Biochemical Society Transactions 33, no. 4 (2005): 643–45. http://dx.doi.org/10.1042/bst0330643.

Full text

Abstract:

Myristoyl-CoA protein:NMT (N-myristoyl transferase) catalyses the N-myristoylation of cellular proteins with a range of functions and is essential for viability in the protozoan parasites, Leishmania major and Trypanosoma brucei. In our investigations to define the essential downstream targets of NMT, we have focused on the ARF (ADP-ribosylation factor) family of proteins, as growth arrest in Saccharomyces cerevisiae mutants with reduced NMT activity correlates with decreased modification of members of this group of proteins. We have identified nine ARF/ARLs (where ARL stands for ARF-like) enc

APA, Harvard, Vancouver, ISO, and other styles

30

Munro, S. "The Arf-like GTPase Arl1 and its role in membrane traffic." Biochemical Society Transactions 33, no. 4 (2005): 601–5. http://dx.doi.org/10.1042/bst0330601.

Full text

Abstract:

Small GTP-binding proteins of the Rab and Arf (ADP-ribosylation factor) families play a central role in the membrane trafficking pathways of eukaryotic cells. The prototypical members of the Arf family are Arf1–Arf6 and Sar1, which have well-characterized roles in membrane traffic or cytoskeletal reorganization. However, eukaryotic genomes encode additional proteins, which share the characteristic structural features of the Arf family, but the role of these ‘Arf-like’ (Arl) proteins is less well understood. This review discusses Arl1, a GTPase that is widely conserved in evolution, and which i

APA, Harvard, Vancouver, ISO, and other styles

31

Christis, Chantal, and Sean Munro. "The small G protein Arl1 directs the trans-Golgi–specific targeting of the Arf1 exchange factors BIG1 and BIG2." Journal of Cell Biology 196, no. 3 (2012): 327–35. http://dx.doi.org/10.1083/jcb.201107115.

Full text

Abstract:

The small G protein Arf1 regulates Golgi traffic and is activated by two related types of guanine nucleotide exchange factor (GEF). GBF1 acts at the cis-Golgi, whereas BIG1 and its close paralog BIG2 act at the trans-Golgi. Peripheral membrane proteins such as these GEFs are often recruited to membranes by small G proteins, but the basis for specific recruitment of Arf GEFs, and hence Arfs, to Golgi membranes is not understood. In this paper, we report a liposome-based affinity purification method to identify effectors for small G proteins of the Arf family. We validate this with the Drosophil

APA, Harvard, Vancouver, ISO, and other styles

32

Martino, Bruno, Claudia Labate, Caterina Alati, et al. "A Genetic Risk Score for Insulin Resistance Identify Patients with Chronic Myeloid Leukemia, Treated with Nilotinib, Developing Diabetes." Blood 128, no. 22 (2016): 3098. http://dx.doi.org/10.1182/blood.v128.22.3098.3098.

Full text

Abstract:

Abstract BACKGROUD: Nilotinib, a potent 2nd generation tyrosin kinase inhibitor, is efficacious in the treatment of chronic myelogenous leukemia (CML). Impaired glucose metabolism represents one of the most frequently observed adverse events and several clinical trials, reported a high diabetes incidence during treatment with this drug. The mechanism of this side effect is poorly understood, but recently has been hypothesized an increased postreceptorial insulin resistence. Moreover, "in vitro"results indicated that c-ABL is involved in the insulin receptor signaling pathway. A large number of

APA, Harvard, Vancouver, ISO, and other styles

33

Schennach, S., A. M�ller, O. Uwira, et al. "Dielectronic recombination of lithium-like Ar15+." Zeitschrift f�r Physik D Atoms, Molecules and Clusters 30, no. 4 (1994): 291–306. http://dx.doi.org/10.1007/bf01426394.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Amor, J. Carlos, John R. Horton, Xinjun Zhu, et al. "Structures of Yeast ARF2 and ARL1." Journal of Biological Chemistry 276, no. 45 (2001): 42477–84. http://dx.doi.org/10.1074/jbc.m106660200.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Rosenwald, Anne G., Mary Ann Rhodes, Hillary Van Valkenburgh, et al. "ARL1 and membrane traffic inSaccharomyces cerevisiae." Yeast 19, no. 12 (2002): 1039–56. http://dx.doi.org/10.1002/yea.897.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Tiplica, Teodor. "ARL1 of the Attribute c Control Chart with Estimated Parameter." International Journal of Reliability, Quality and Safety Engineering 22, no. 02 (2015): 1550009. http://dx.doi.org/10.1142/s0218539315500096.

Full text

Abstract:

In this paper, the out of control average run length (ARL1) of the c control chart with estimated parameter is computed for various shifts in the average number of nonconformities. In spite of the discrete nature of this chart, it is proved that a target in-control average run length (ARL0) can be obtained when the average number of nonconformities is estimated. This is a good starting point for comparing the performances of the c control chart with those of other attribute control charts with estimated parameters. Based on the computational results obtained, it is showed that the ARL1 of the

APA, Harvard, Vancouver, ISO, and other styles

37

Ma, Qing, Lingping Kong, and Diansheng Zhong. "Abstract 5231: Case report: dramatic response to Crizotinib in a patient with synchronous multiple primary lung cancer positive for a novel ARL1-MET fusion." Cancer Research 82, no. 12_Supplement (2022): 5231. http://dx.doi.org/10.1158/1538-7445.am2022-5231.

Full text

Abstract:

Abstract Background: With the use of high-resolution chest imaging system, an increasing number of lung cancer patients are being diagnosed with multiple primary lung cancer (MPLC). Although surgery is considered as the first choice of treatment for early MPLC, targeted therapy is essential in the management of unresectable MPLC. To date, the driver oncogenes reported in the patients with MPLC are limited, and MET fusion has not yet been reported in MPLC. Case presentation: In this case, we reported a female patient with simultaneous MPLC (sMPLC). A novel ARL1-MET fusion was detected in her ri

APA, Harvard, Vancouver, ISO, and other styles

38

Jochum, Alexandra, David Jackson, Heinz Schwarz, Rüdiger Pipkorn, and Birgit Singer-Krüger. "Yeast Ysl2p, Homologous to Sec7 Domain Guanine Nucleotide Exchange Factors, Functions in Endocytosis and Maintenance of Vacuole Integrity and Interacts with the Arf-Like Small GTPase Arl1p." Molecular and Cellular Biology 22, no. 13 (2002): 4914–28. http://dx.doi.org/10.1128/mcb.22.13.4914-4928.2002.

Full text

Abstract:

ABSTRACT We previously described the isolation of ysl2-1 due to its genetic interaction with Δypt51/vps21, a mutant with a deletion of the coding sequence for the yeast Rab5 homolog, which regulates endocytic traffic between early and late endosomes. Here we report that Ysl2p is a novel 186.8-kDa peripheral membrane protein homologous to members of the Sec7 family. We provide multiple genetic and biochemical evidence for an interaction between Ysl12p and the Arf-like protein Arl1p, consistent with a potential function as an Arf guanine nucleotide exchange factor (GEF). The temperature-sensitiv

APA, Harvard, Vancouver, ISO, and other styles

39

Ireland, Stephen C., Haoran Huang, Jianchao Zhang, Jie Li, and Yanzhuang Wang. "Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking." Molecular Biology of the Cell 31, no. 17 (2020): 1931–42. http://dx.doi.org/10.1091/mbc.e20-01-0063.

Full text

Abstract:

H2O2 treatment induces the degradation of Golgi structural proteins in the trans-Golgi, including Arl1, Golgin-97, and Golgin-245, and thereby impairs membrane trafficking. This study revealed the trans-Golgi and trafficking at the trans-Golgi as novel targets of ROS in cells.

APA, Harvard, Vancouver, ISO, and other styles

40

Zaman, Bisma, Syed Muhammad Muslim Raza, Javed Iqbal, Naima Shehzadi, Muhammad Moeen Butt, and Muhammad Riaz. "Efficient control charting methodology based on Distance Weighted Mean for normal distribution." Natural and Applied Sciences International Journal (NASIJ) 4, no. 1 (2023): 1–16. http://dx.doi.org/10.47264/idea.nasij/4.1.1.

Full text

Abstract:

This research suggests a Distance Weighted Mean (DWM) based control chart under normal distribution implementing Simple Random Sampling (SRS). The control limits are calculated using the quantile point method. The control chart's performance is assessed using the Average Run Length (ARL) statistic. The numerical findings are illustrated using samples of sizes 3 and 5. The ARL1 values are determined using Monte Carlo Simulation for increasing and decreasing shifts in the location parameter ranging from 5% to 30%. Using the ARL1 measurement, the proposed DWM control charts are compared to the ex

APA, Harvard, Vancouver, ISO, and other styles

41

Huang, Lien-Hung, Wei-Chung Lee, Shu-Ting You, Chia-Chen Cheng, and Chia-Jung Yu. "Arfaptin-1 Negatively Regulates Arl1-Mediated Retrograde Transport." PLOS ONE 10, no. 3 (2015): e0118743. http://dx.doi.org/10.1371/journal.pone.0118743.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Munson, A. M. "Yeast ARL1 encodes a regulator of K+ influx." Journal of Cell Science 117, no. 11 (2004): 2309–20. http://dx.doi.org/10.1242/jcs.01050.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Lu, W., W. Zhang, S. S. Molloy, et al. "Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin." Journal of Biological Chemistry 268, no. 20 (1993): 14583–85. http://dx.doi.org/10.1016/s0021-9258(18)82370-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Knoop, S., D. Fischer, Y. Xue, et al. "Single-electron capture in keV Ar15+…18++He collisions." Journal of Physics B: Atomic, Molecular and Optical Physics 41, no. 19 (2008): 195203. http://dx.doi.org/10.1088/0953-4075/41/19/195203.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Zhang, Binbin, Aiqun Xu, Dong Wu, et al. "ARL14 as a Prognostic Biomarker in Non-Small Cell Lung Cancer." Journal of Inflammation Research Volume 14 (December 2021): 6557–74. http://dx.doi.org/10.2147/jir.s340119.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Yu, Chia-Jung, and Fang-Jen S. Lee. "Multiple activities of Arl1 GTPase in the trans-Golgi network." Journal of Cell Science 130, no. 10 (2017): 1691–99. http://dx.doi.org/10.1242/jcs.201319.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Chen, K. Y., P. C. Tsai, J. W. Hsu, et al. "Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p." Journal of Cell Science 123, no. 20 (2010): 3478–89. http://dx.doi.org/10.1242/jcs.074237.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Nogales Rincón, David. "Maribel Fierro y Alejandro García Sanjuán (eds.), Hispania, al-Ándalus y España. Identidad y nacionalismo en la Historia." Conceφtos, no. 1 (December 21, 2020): 259–62. http://dx.doi.org/10.46608/conceptos2020a/art15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Martínez López, Diego. "Modernidad y guerra total: los primeros pasos del orden antiaéreo republicano durante la Guerra Civil española (1936-1937)." Conceφtos, no. 2 (December 31, 2020): 243–57. http://dx.doi.org/10.46608/conceptos2020b/art15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

GAFFIN, RICHARD B. "The Reformed Dogmatics of Geerhardus Vos." Unio Cum Christo 4, no. 1 (2018): 127. http://dx.doi.org/10.35285/ucc4.1.2018.art15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!