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Academic literature on the topic 'Aristolochia acids'

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Published: 4 June 2021
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Journal articles on the topic "Aristolochia acids"

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Da Silva, Antonio Jorge Ribeiro, Maria Auxiliadora Coelho Kaplan, Celuta Sales Alviano, Daniela Sales Alviano Moreno, Davi Oliveira e. Silva, and Péricles Barreto Alves. "Determination of Aristolochic Acids I and II in Brazilian Sugar Cane Spirit Infusions “milhomem” Commonly used in Northeast Brazil as Popular Drinks." Revista Fitos 14, no. 01 (March 31, 2020): 38–44. http://dx.doi.org/10.32712/2446-4775.2020.808.

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Aristolochic acids (AA) are phytochemicals found in plants of the genus Aristolochia belonging to the family Aristolochiaceae. These compounds bear a nitrophenanthrene carboxylic acid skeleton and are reported to be carcinogenic, mutagenic, and nephrotoxic. Sugar cane spirit infusions containing Aristolochia species are commonly used in Brazil as popular drinks, in total absence of scientific information. The presence aristolochic acids was confirmed in samples collected in popular markets of the city of Aracaju, Sergipe, Brazil. The aristolochic acids quantitative estimation was made in five samples of sugar cane spirit infusions obtained from different places of that city and were performed by high-performance liquid chromatography. The samples analyzed contained aristolochic acids I and II in concentrations ranging between 1.96 and 6.10 µg/ml for AA I and 2.22 and 11.55 µg/ml for AA II. The immediate banning of such popular drinks is recommended in view of the danger to ingest aristolochic acids, botanical products containing aristolochic acids or herbal products containing plants belonging to Aristolochiaceae family.
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Houghton, Peter J., and Muzaffer Ogutveren. "Aristolochic acids and aristolactams from Aristolochia auricularia." Phytochemistry 30, no. 1 (January 1991): 253–54. http://dx.doi.org/10.1016/0031-9422(91)84131-b.

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Zhang, Hong-Chi, Rui Liu, Zhi-peng An, Hui Li, Rui Zhang, and Feng Zhou. "Aristolactam-type alkaloids and aristolochic acids from Aristolochia moupinensis and Aristolochia cathcartii." Biochemical Systematics and Ecology 65 (April 2016): 198–201. http://dx.doi.org/10.1016/j.bse.2016.02.028.

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Yun, Byeong Hwa, Viktoriya S. Sidorenko, Thomas A. Rosenquist, Kathleen G. Dickman, Arthur P. Grollman, and Robert J. Turesky. "New approaches for biomonitoring exposure to the human carcinogen aristolochic acid." Toxicology Research 4, no. 4 (2015): 763–76. http://dx.doi.org/10.1039/c5tx00052a.

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Al-Busafi, Saleh, Munir Al-Harthi, and Bushra Al-Sabahi. "Isolation of Aristolochic Acids from Aristolochia Bracteolata and Studies of their Antioxidant Activities." Sultan Qaboos University Journal for Science [SQUJS] 9 (June 1, 2004): 19. http://dx.doi.org/10.24200/squjs.vol9iss0pp19-23.

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The isolation and structural elucidation of aristolochic acid-A and aristolochic acid-D from Omani Aristolochia bracteolata plant is reported. Antioxidant activities of these two natural products were evaluated for their capacity to reduce Mo(VI) to Mo(V). The study revealed that aristolochic acid-D is more active than vitamin C while aristolochic acid-A has activity similar to vitamin C.
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Nascimento, Isabele R., and Lucia M. X. Lopes. "Diterpene esters of aristolochic acids from Aristolochia pubescens." Phytochemistry 63, no. 8 (August 2003): 953–57. http://dx.doi.org/10.1016/s0031-9422(03)00335-2.

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Priestap, Horacio A. "Minor aristolochic acids from Aristolochia argentina and mass spectral analysis of aristolochic acids." Phytochemistry 26, no. 2 (January 28, 1987): 518–29. http://dx.doi.org/10.1016/s0031-9422(00)81447-8.

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Chan, Chi-Kong, Yushuo Liu, Nikola Pavlović, and Wan Chan. "Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases." Toxics 7, no. 1 (March 19, 2019): 14. http://dx.doi.org/10.3390/toxics7010014.

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Aristolochic acids (AAs) are nitrophenanthrene carboxylic acids naturally produced by Aristolochia plants. These plants were widely used to prepare herbal remedies until AAs were observed to be highly nephrotoxic and carcinogenic to humans. Although the use of AA-containing Aristolochia plants in herbal medicine is prohibited in countries worldwide, emerging evidence nevertheless has indicated that AAs are the causative agents of Balkan endemic nephropathy (BEN), an environmentally derived disease threatening numerous residents of rural farming villages along the Danube River in countries of the Balkan Peninsula. This perspective updates recent findings on the identification of AAs in food as a result of the root uptake of free AAs released from the decayed seeds of Aristolochia clematitis L., in combination with their presence and fate in the environment. The potential link between AAs and the high prevalence of chronic kidney diseases in China is also discussed.
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Santander, Rocío, Alejandro Urzúa, Ángel Olguín, and María Sánchez. "Temporal Variation of Aristolochia chilensis Aristolochic Acids during Spring." Molecules 20, no. 11 (November 13, 2015): 20391–96. http://dx.doi.org/10.3390/molecules201119704.

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Tian-Shung, Wu, Ou Li-Fei, and Teng Che-Ming. "Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis." Phytochemistry 36, no. 4 (July 1994): 1063–68. http://dx.doi.org/10.1016/s0031-9422(00)90492-8.

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Dissertations / Theses on the topic "Aristolochia acids"

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Liang, Qing You. "Study on supercritical fluid extraction of aristolochic acids in Aristolochia plants." Thesis, University of Macau, 2007. http://umaclib3.umac.mo/record=b1676801.

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Cheung, Thomas Pak Fai, and tom cheung@rmit edu au. "Risk assessment and determination of aristolochic acids and heavy metals in Chinese herbal medicines." RMIT University. Health Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080414.145522.

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There is community concern about toxic contaminants in Chinese herbal medicines. The two areas of contamination that attract most attentions are the nephrotoxic chemical, aristolochic acids found to be present in some Chinese herbs and resulting in renal failure of over 200 patients in Belgium, and heavy metals such as lead, arsenic, cadmium, mercury and chromium, which can cause systemic, CNS, neurological and developmental pathologies. Currently there is a lack of systematic information about the aristolochic acid content in Aristolochia species and related genera, nor have there been any studies on metal contamination conducted in Australia which can provide some scientific basis for assessment of potential risk of Chinese herbal medicines posed to consumers in Australia. This research aimed at addressing these concerns by firstly carrying out a systematic measurement of the contents of aristolochic acids in some relevant raw herbal medicines (CHM) and proprietary medicines (CPM)- 27 CHM, and 7 CPM, and secondly analysing the contents of five heavy metals in 100 CHM, 50 CPM, and 5 commonly used Chinese medicinal formulae (CMF) in the form of raw herbs, and finally evaluating the potential systemic metal toxicity caused by routine ingestions of Chinese medicines in the common form of encapsulated concentrated powder extracts formulated for the treatment of seasonal allergic rhinitis by means of measuring the metal concentrations in blood collected from 71 patients in a randomised double-blind control clinical trial (RCT). Results showed that four of the 37 CHM and two of the 7 CPM contained the banned toxic aristolochic acids. Some of these contaminated medicines could still be purchased over-the-counter in Victoria. Quantitative screening of metal contamination in CHM found that metal concentrations were much lower in the aqueous solutions than in the acid-digested samples. Almost all CHM, CPM and the 5 CMF contained the five heavy metals. Contrary to popular perception, their metal concentrations in the clinically ingested form were extremely low. Their prescribed ingested contents calculated as percentages of the universally recognised regulatory safety standards, the WHO provisional tolerable weekly intake (PTWI), would produce only small percentages of the PTWI for the metal concerned. This was true even when the metal intakes from any forms of Chinese medicines were added to the normal Australian daily dietary metal exposure. These new approaches of analysing the aqueous extractions, as well as interpretation with reference to the WHO regulatory standards and in combination with the Australian normal daily diet, are more relevant and realistic. The RCT in vivo study demonstrated no significant metal accumulation in the blood of both the real treatment group and the placebo control group, thus, attesting to the encouraging finding of the herbal medicine analysis. In conclusion, there is still much to improve in Australia in terms of enforcing the regulation of banning the sale of Chinese herbal medicines that might contain the highly nephrotoxic aristolochic acids. On the other hand, all forms of Chinese medicines in Victoria are safe, and do not appear to pose significant health concerns in terms of metal contamination.
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Alamin, Abdelgadir. "Apport de la chromatographie de partage centrifuge à l'étude phytochimique de 3 plantes utilisées en médecine traditionnelle soudanaise." Thesis, Tours, 2016. http://www.theses.fr/2016TOUR3812/document.

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Ce travail de thèse est une contribution à l’étude phytochimique par Chromatographie de Partage Centrifuge (CPC), de trois plantes utilisées en médecine traditionnelle au Soudan : Aristolochia bracteolata (plante entière), Ziziphus spina-christi (feuilles) et Hydnora abyssinica (rhizomes). Ce travail a permis de mettre au point trois méthodologies de purification par CPC, applicables au fractionnement des acides aristolochiques, des flavonoïdes ou des proanthocyanidols (PAC). Dans ce contexte, la première partie de ce manuscrit est consacrée aux notions générales portant sur la CPC. La deuxième partie porte sur l’étude d’Aristolochia bracteolata. Cette plante est utilisée en médecine traditionnelle, malgré la présence d'acides aristolochiques qui confèrent une néphrotoxicité élevée. Ce travail a permis de mettre au point une méthode innovante pour l’isolement et la purification, avec un très haut niveau de pureté, des acides aristolochiques I, II et IIIa à partir d’un extrait brut, en une étape par CPC en mode d’échange d’ions forts (SIX-CPC). L’acide aristolochique IIIa n’avait jamais été décrit dans cette plante auparavant. Ces résultats ont fait l’objet d’une publication en 2015 dans Separation and Purification Technology. Dans la troisième partie de cette thèse, la CPC a été appliquée à l’isolement de flavonosides présents dans Z. spina-christi. Nous appuyant sur l’expérience du laboratoire dans l’extraction par CPC des flavonosides du Ginkgo biloba, nous proposons une méthodologie de purification utilisant les systèmes de solvant biphasiques EtOAc/n-BuOH/MeOH/H2O et EtOAc/n-BuOH/H2O à différents ratios en fonction de la polarité des flavonosides. Dans la dernière partie, l’étude phytochimique de Hydnora abyssinica a mis en évidence la présence de PACs, polymères de hauts poids moléculaires de flavanols. La méthodologie de fractionnement CPC, précédée d’un pré-fractionnement sur résine LH-20, a permis l’isolement pour la première fois dans cette plante de la katsumadine et du rhodioloside
This work was a contribution to the phytochemical study of three Sudanese medicinal plants: Aristolochia bracteolata (Whole plant), Ziziphus spina-christi (Leaves) and Hydnora abyssinica (Rhizomes). The specificity of this research program was to emphasize the application of Centrifugal Partition Chromatography (CPC) for the fractionation of these plants. Three specific CPC methodologies were developed for the purification of either aristolochic acids, flavonoids or proanthocyanidins (PACs). In this context, the first part of this manuscript was devoted to the presentation of the CPC methodology. The second part focused on the fractionation of crude extract of Aristolochia bracteolata. This plant is used in traditional medicine, in spite of the presence of aristolochic acids that confer a high nephrotoxicity. In this work was developed an innovating procedure for the isolation and purification in high purity of aristolochic acids I, II and IIIa, in one step from crude extract, using Strong Ions eXchange CPC (SIX-CPC). These results were published in 2015 in Separation and Purification Technology. In the third part, the flavonosides present in Z. spina-christi were isolated using CPC, either in normal or reverse elution mode, using two phases solvent systems EtOAc/n-BuOH/MeOH/H2O or EtOAc/n-BuOH/H2O with different ratios. In the last part, the phytochemical study of Hydnora abyssinica led to the fractionation of PACs, polymers of high molecular weight of flavanols. The CPC fractionation methodology, preceded by LH-20 resin pre-fractionation, allowed the isolation of katsumadine and rhodioloside
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Zhou, Li, and 周莉. "The molecular mechanisms of aristolochic acid nephropathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224349.

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Zhou, Li. "The molecular mechanisms of aristolochic acid nephropathy." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43224349.

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Rodriguez, Isela Iveth Gonzales. "Avaliação da atividade antiofídica de \"Aristolochia sprucei\": Isolamento e caracterização estrutural de composto bioativo." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-01092010-005832/.

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Muitas espécies do gênero Aristolochia (Familia Aristolochiaceae) têm sido usadas na medicina tradicional e folclórica como medicamentos e tônicos, as quais demonstravam atividades farmacológicas de interesse clínica e medica como anti-hemorrágica, anti-parasita, antibacteriano, antifúngico, analgésico, antitumoral entre outras. Visando a obtenção de mais informações sobre essas plantas e na procura por substâncias com efeitos antiofídicos, neste trabalho avaliou-se à ação de extratos aquoso, metanólico e de acetato de etila de folhas e caule contra as ações tóxicas da peçonha de Bothrops asper, ambos procedentes do Panamá e contra o efeito miotóxico da peçonha de Bothrops jararacussu e das miotoxinas BthTX-I (isolada de B. jararacussu) e Mtx-II (isolada de B. asper). O extrato das folhas em acetato de etila apresentou a melhor inibição da atividade fosfolipásica da peçonha de B. asper, demonstrando inibição de 45%, 35% e 33% nas proporções de 1:5, 1:10 e 1:30 (m/m), respectivamente. Enquanto que, o extrato de caule em acetato de etila demonstrou maior eficácia na neutralização da atividade coagulante, e, além disso, inibiu 96%, 92% e 87% do edema, da miotoxicidade e hemorragia induzidas pela peçonha de B. asper, respectivamente. Os percentuais diferenciados na neutralização das ações tóxicas da peçonha de Bothrops asper, revelam diferentes perfis do potencial antiofídico de Aristolochia sprucei. Um dos componentes bioativos foi isolado do extrato de caule desta planta por CLAE, e a caracterização química, por ressonância magnética nuclear, demonstrou ser o ácido aristolóquio que inibiu a atividade miotóxica das peçonhas de B. jararacussu e de B. asper em 80% e 85% e assim como a atividade miotóxica da BthTX-I e Mtx-II em 64% e 60%, respectivamente. A atividade hemolítica indireta da peçonha de B. asper foi inibida em 43% pelo o ácido aristolóquio. A análise dos espectros de dicroísmo circular e os estudos de interação por modelagem molecular sugerem que o ácido aristolóquio forma um complexo com a Mtx-II de B. asper inibindo sua atividade. A ligação do ácido aristoloquio com as miotoxinas (MjTX-1, BthTX-II) modificou a forma e a intensidade dos espectros de dicroísmo circular da miotoxina e induziu alterações na porcentagem dos diversos domínios que constituem a estrutura secundária desta miotoxina. Os resultados obtidos confirmam que os extratos de A. sprucei possuem propriedades antiofídicas e sugerem a necessidade de aprofundar estudos que permitam utilizar com segurança os extratos e o principio ativo isolado como suplementos dos antisoros para aumentar a eficácia na neutralização dos efeitos tóxicos locais da peçonha das serpentes.
A lot of species of genus Aristolochia (Familia Aristolochiacheae) have been used in traditional medicine and folk, such as medicaments and tonics, which show pharmacological activities of clinic and medical interest, like antihemorragic, antiparasitic, antibacterial, antifungic, analgesic, antitumoral between others. Expecting to get more information about these plants and in the search by substances with antiophidic effects, in this work was evaluated the action of aqueous, metanolic and ethyl acetate extracts from leaves and stems of Aristolochia sprucei against the toxic action of Bothrops asper venom, both native from Panamá and against the myotoxic effect of Bothrops jararacussu venom and BthTX1 (isolated from B. jararacussu) and Mtx-II (isolated from Bothorps asper). The leaves extracts in ethyl acetate showed the best inhibition registered of PLA2 activity of venom de B. asper showing inhibition of 45 %, 35 % and 33 %, in proportion (m/m) of 1:5, 1:10 and 1:30 respectively. As regards to stem extract in ethyl acetate, it showed high efficacy in neutralization of coagulant activity, besides It inhibited 96 %, 92 % and 87 % of edema, myotoxicity and hemorrhage induced by B. asper venom, respectively. One of bioactives components was isolated from stem extract of this plant by CLAE and the chemical characterization by nuclear magnetic resonance, this showed that the compound is the aristolochic acid. This compound inhibited the myotoxic activity of B. jararacussu and B. asper venom in 80 % and 85 %, so like myotoxic activity of BthTx-I and MTx-II in 64 % and 60 % respectively. The indirect hemolytic activity of B. asper venom was inhibited in 43 % by the aristolochic acid. The analyze of spectrum of circular dichroism and the studies of interaction by molecular modelagem suggest that the aristolochic acid forms a complex 1:1 with the miotoxin inhibiting their activity. The joint of aristolochic acid with the miotoxins (MjTX-1, BthTx-II) changes the way and the intensity of spectra from dichroism circular of miotoxin and It induced alteration in percentage of several domains that constitute a secondary structure from this toxin. The results obtained confirm that the extracts of A. sprucei have antiophidic properties and it suggest the necessity of deepen studies that allow to use with safety the extracts and the isolated active principle, like antiserum supplements to increase the efficacy in the neutralization of local toxics effects of snakes venoms.
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Duquesne, Marilyn. "A translational study of the nephrotoxicity of aristolochic acids by a metabonomic approach in NMR spectroscopy validated by conventional biomarkers." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/268946.

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Utilisation de la métabonomique en spectroscopie RMN pour l'identification de biomarqueurs d'exposition à l'acide Aristolochique. Développement de modèles expérimentaux chez des rats mâles. Analyse d'échantillons urinaires provenant de patients croates potentiellement touchés par la Néphropathie endémique des Balkans
Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished
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Srđan, Živojinov. "Razvoj animalnog modela nefrotoksične tubulointersticijalne lezije." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=99867&source=NDLTD&language=en.

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U eksperimantalnom postupku disertacije miševi NMRI soja su tretirani infuzom biljke Aristolochia clematitis. Sasušeni listovi, grane i plodovi biljke potopljeni su u ključalu vodu i ostavljeni 3-5 sati da stoje, a potom su profiltrirani kroz filter papir. Pravljen je rastvor biljke/vode od 10g/ 1000ml (1%), 20g/ 1000ml (2%) i 40g/ 1000ml (4%). Različite koncentracije infuza su date miševima da piju u neograničenoj količini u periodu od 7 nedelja. Tako su formirane tri ispitne grupe, prva koja je primala 1% infuz, druga 2% infuz i treća 4% infuz i kontrolna grupa koja je dobijala samo vodu da pije. U svakoj grupi je bilo 20 životinja. Tako je razvijen animalni model hronične toksičnosti. Na kraju eksperimenta je urađena patohistološka analiza bubrega, makroskopski pregled organa i merenje diureze tokom trajanja eksperimenta. Urađena je kompletna analiza urina koja podrazumeva utvrđivanje: boje, izgleda, pH, specifične težine, proteina i sedimenta urina. Analize urina ponavljane su na svakih 7 dana u toku 7 nedelja istraživanja. Na kraju eksperimenta urađena je analiza biohemijskih parametara (glukoza, urea, kreatinin, mokraćna kiselina, ukupni bilirubin, direktni bilirubin, ukupni tj. totalni proteini, natrijum i kalijum) i analiza kompletne krvne slike. Utvrđeno je da je Aristolochia clematitis izrazito nefrotoksična biljka. Utvrđene su patohistološke promene tubula i intersitcijuma NMRI miša, koje su bile najveće u ispitnoj grupi koja je primala najaču dozu. Ustanovljene  patohistološke promene su slične opisanim patohistološkim promenama tubulointersticijuma bolesnika obolelih od Balkanske endemske nefropatije. Nije ustanovljeno postojanja karcinoma gornjeg urotrakta. Makroskopskim pregledom prilikom obdukcije eksperimentalnih životinja nisu ustanovljene značajnije promene bubrega. Došlo je prvo do izrazitog porasta diureze u prvoj, odnosno drugoj nedelji praćenja, kod druge i treće eksperimentalne grupe, da bi nakon 7 nedelja istaživanja diureza u svim ispitnim grupama bila manja od kontrolne grupe. Postoji porast ureje na kraju istraživanja, koji je dvostruko veći u trećoj eksperimentalnoj grupi u odnosu na kontrolnu. Postoji izrazit pad mokraćne kiseline na kraju istraživanja kod eksperimentalne grupe 3. Postoji izrazit pad granulocita u leukocitarnoj formuli u svim ispitnim grupama, a najveći je u trećoj ispitnoj grupi. Kako je došlo do pada relativnih vrednosti granulocita, tako je došlo do porasta relativnih vrednosti limfocita u prvoj i drugoj ispitnoj grupi. U trećoj ispitnoj grupi je pad granulocita praćen izrazito velikim povećanjem relativnog broja bazofilnih granulocita. Postoji značajan pad specifične težine urina na kraju istraživanja u drugoj i trećoj eksperimentalnoj grupi. Proteinurija je bila čest nalaz svim eksperimentalnim grupama, dok je bila odsutna ili samo u tragu u kontrolnoj grupi. Na kraju eksperimenta je utvrđen znatni porast broja kristala fosfata u eksperimentalnim grupama. Cilindri su se pojavljivali samo u nalazu urina u trećoj ispitnoj grupi. Najveći broj promena urina je utvrđen u trećoj eksperimentlanoj grupi.
In the experimental procedure of dissertation, NMRI strain mice were treated with infusion of plants Aristolochia clematitis. Dried leaves, branches and fruit plants are submerged in boiling water and left to stand for 3-5 hours, and then filtered through filter paper. It was made a solution of the plant / water of 10g / 1000ml (1%), 20g / 1000ml (2%) and 40g / 1000ml (4%). Different concentrations of infusions were given to mice to drink an unlimited amount for a period of 7 weeks. So we formed the three test groups, the first who received 1% infusion, the second received 2% infusion and third received 4% infusion and a control group that received only water to drink. In each group there were 20 animals. Thus, developed an animal model of chronic toxicity. At the end of the experiment was performed histopathological analysis of kidneys, macroscopic examination of organs and measuring urine output during the experiment. We performed a complete analysis of urine, which is the determination of: color, appearance, pH, specific gravity, protein and urine sediment. Urinalysis were repeated every 7 days during the 7 weeks of the study. At the end of the experiment were analyzed for biochemical parameters (glucose, urea, creatinine, uric acid, total bilirubin, direct bilirubin, total proteins, sodium and potassium) and analysis of the complete blood count. It has been found that Aristolochia clematitis is extremely nephrotoxic plant. Identified histopathological changes of tubules and interstitium of NMRI mouse, which were the biggest in the test group receiving biggest dose. Established histopathological changes are similar to those described by pathological changes of tubulointerstitial injury of patients with Balkan endemic nephropathy. Not established the existence of cancer of the upper urinary tract. Macroscopic examination at autopsy of experimental animals, did not determine significant changes in the kidneys. There is first an enormous increase in diuresis in the first and second week of follow-up, in the second and third experimental groups retrospectively, that after 7 weeks of research, diuresis in all test groups was lower than the control group. There is an increase of urea at the end of the research, which is twice higher in the third experimental group compared to the control. There is a marked decrease in uric acid at the end of the research in the experimental group 3. There is a marked decrease in granulocytes in the leukocyte formula in all test groups, and the highest in the third test group. As the decline in the relative values of granulocytes, so there has been a rise in the relative values of lymphocite in the first and second test group. In the third test group, granulocyte drop was accompanied by a extremely large increase in the relative number of basophils. There is a significant drop in specific gravity of urine at the end of the research in the second and third experimental group. Proteinuria is a common finding to all experimental groups, while it was absent or only in traces in the control group. At the end of the experiment was determined to increase significantly the number of phosphate crystals in the experimental groups. The cylinders have appeared only in the urine in the third test group. The greatest number of changes in the urine is determined in the third experimental group.
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Ardin, Maude. "Investigating cancer aetiology through the analysis of somatic mutation signatures." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1236/document.

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Les cellules cancéreuses sont caractérisées par des altérations de l'ADN causées par des facteurs exogènes, comme l'exposition à des agents environnementaux tels que le tabac ou les UV, ou par des mécanismes endogènes tels que les erreurs de polymérase lors de la réplication de l'ADN. L'analyse des causes et des conséquences de ces altérations permet de mieux comprendre les facteurs et mécanismes à l'origine du développement d'un cancer. Les technologies de séquençages à haut débit offrent l'opportunité d'étudier la nature précise de ces altérations à l'échelle du génome et permettent de révéler des signatures mutationnelles distinctes et spécifiques de cancérigènes, fournissant ainsi des hypothèses sur l'étiologie des cancers.L'objectif de ma thèse a consisté à développer des méthodes et des outils bioinformatiques accessibles et conviviaux permettant de faciliter l'analyse et l'interprétation des signatures mutationnelles à partir de données de séquençage à haut débit. L'application de ces outils et méthodes à des séries originales de tumeurs humaines et de systèmes expérimentaux de mutagénèse et carcinogénèse a permis de mieux caractériser la signature mutationnelle de l'acide aristolochique (AA) ainsi que d'autres cancérigènes d'intérêt
Cellular genomes accumulate alterations following exposures to exogenous factors, like environmental agents such as tobacco smoking or UV, or to endogenous mechanisms such as DNA replication errors. Analysing the causes and consequences of these changes allows a better understanding of the mechanisms underlying cancer development and progression. Next-generation sequencing (NGS) technologies provide the opportunity tostudy the nature of the resulting alterations on a genome-wide scale and started to reveal distinct mutational signatures specific to past carcinogenic exposures providing clues on cancer aetiology.The aim of my thesis was to develop user-friendly bioinformatic tools and methods for facilitating the analysis and interpretation of carcinogen-specific mutational signatures from NGS data. Applying these tools and methods to human tumours and experimental models of mutagenesis led to a better characterisation the mutational signature of aristolochic acid (AA), as well as other carcinogens of interest
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Chan, Wan. "Development and application of liquid chromatography and electrospray-ionization mass spectrometry methods for herbal medicine analysis and for the studies of metabolism, DNA adducts and metabonomics of aristolochic acids." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/891.

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Books on the topic "Aristolochia acids"

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Gökmen, M. Refik, and Graham M. Lord. Aristolochic acid nephropathy caused by ingestion of herbal medicinal products. Edited by Adrian Covic. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0089.

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Aristolochic acid nephropathy (AAN) is a rapidly progressive renal disease caused by the ingestion of plant products containing aristolochic acid (AA), first described in connection with the use of Chinese herbal medicines. Although the true worldwide extent of this disease is unknown, it is likely to represent a significant cause of chronic kidney disease (CKD) in many parts of the world. Furthermore, recent data have also demonstrated that AA is also the primary aetiological agent in Balkan endemic nephropathy. AAN is notable in its association with urothelial malignancy, with the mechanisms of carcinogenesis now well characterized. Aside from a possible role for corticosteroid therapy in slowing disease progression in selected patients, no disease-specific treatments have yet been shown to alter the course of this nephropathy. Therefore, prevention of exposure to AA and, in affected patients, effective management of the risk of malignancy are key principles in the approach to this condition. Although preparations containing Aristolochia spp. and herbs that can be confused or substituted for Aristolochia have been banned in many countries, other herbal products containing AA have continued to be available to consumers long after these bans have been instituted, highlighting the ongoing need for awareness of this disease.
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Weaver, Virginia M., Bernard G. Jaar, and Jeffrey J. Fadrowski. Kidney Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0031.

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This chapter describes kidney disorders related to occupational and environmental exposures and addresses prevention and control. Sections address assessment of kidney function, acute kidney injury, and chronic kidney disease (CKD). Kidney disease from acute, high-level exposures as well as lower level exposures in combination with other CKD risk factors are considered. Established nephrotoxicants, including aristolochic acid, arsenic, cadmium, lead, melamine, mercury, silica, and solvents, are discussed. The limited data available on other agents, such as perfluorooctanoic acid and fine particulate matter, are also presented. The potential for kidney function to impact biomarker levels is considered. A final section addresses a current epidemic of CKD of unknown etiology in agricultural workers in specific countries.
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Radović, Milan, and Adalbert Schiller. Balkan endemic nephropathy. Edited by Adrian Covic. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0090_update_001.

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Balkan endemic nephropathy (BEN) is a chronic, slowly progressive tubulointerstitial nephritis, with familial clustering, occurring in several endemic rural regions in countries of the Balkan Peninsula. BEN is characterized by anaemia, tubular proteinuria, renal shrinkage, and slowly declining glomerular filtration rate (GFR). Up to one-third of patients may also develop upper urothelial tumours. The aetiology of BEN is unclear; chronic exposure to aristolochic acid and a polygenic predisposition are the most likely contributing factors. The major pathological characteristics of BEN are symmetrically shrunken, smooth-shaped kidneys, with interstitial fibrosis, mild interstitial inflammation, and tubular atrophy. Diagnosis is usually based upon positive family history of BEN, past or current residence in endemic regions, tubular proteinuria, tubular dysfunctions (such as urine acidification defects, salt wasting, and impaired excretion of ammonia, uric acid, and phosphate), scant urinary sediment, bilateral and symmetrically reduced kidney size, accompanied by severe anaemia, disproportionate to the degree of GFR reduction. There is no specific therapy for BEN; patients should therefore be treated as all patients with chronic kidney disease, in general. The use of distant water supplies or moving to another residence area should be advised to affected families. Careful evaluation for urothelial cancers is mandatory in patients with haematuria.
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Book chapters on the topic "Aristolochia acids"

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Yan, Rong, Li Li, and Guan-Hua Du. "Aristolochic Acid." In Natural Small Molecule Drugs from Plants, 671–74. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8022-7_108.

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Sidorenko, Viktoriya S. "Biotransformation and Toxicities of Aristolochic Acids." In Advances in Experimental Medicine and Biology, 139–66. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41283-8_9.

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Vanherweghem, Jean-Louis, Frederic Debelle, Marie-Carmen Muniz-Martinez, and Joëlle Nortier. "Aristolochic acid nephropathy after Chinese herbal remedies." In Clinical Nephrotoxins, 579–86. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/1-4020-2586-6_29.

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Debelle, Frédéric, Marie-Carmen Muniz-Martinez, Jean-Louis Vanherweghem, and Joëlle Nortier. "Herbal remedies containing aristolochic acid and mushroom nephrotoxicity." In Clinical Nephrotoxins, 757–69. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-84843-3_33.

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Jelaković, Bojan, Živka Dika, and Arthur P. Grollman. "Endemic (Balkan) Nephropathy: A Disease Caused by Aristolochic Acid." In Environmental and Food Safety and Security for South-East Europe and Ukraine, 219–27. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2953-7_20.

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Chen, Chien-Ming, Yih-Huei Uen, Chen-Yi Kuo, Tzu-Chuan Huang, and Jen-Ai Lee. "Fluorimetric Determination of L-3-Hydroxybutyrate Concentrations in the Serum of Normal and Aristolochic Acid-Treated Mice." In Bio-Science and Bio-Technology, 63–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-10616-3_9.

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Schmeiser, H. H., J. Lyons, J. W. G. Janssen, C. R. Bartram, H. R. Scherf, W. Pfau, and M. Wiessler. "Aristolochic Acid I Induced Tumors in Wistar Rats Contain Activating Mutations in Codon 61 of the H-ras Protooncogene." In ras Oncogenes, 261–62. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-1235-3_33.

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Lamari, Zohra, and Houria Negache. "Analysis of Aristolochia longa L. Medicinal Plant from Algeria." In Trace Elements and Their Effects on Human Health and Diseases. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95298.

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In recent time, the therapeutic use of medicinal plants has increased all over the world. The efficacy of herbs for curative purposes is often accounted of its mineral and organic constituents. Neutron activation analysis (INAA) has been applied to mineral determination of Aristolochia Longa (bereztem), medicinal plant used to cure some diseases observed in Algeria especially cancer. In this work the mass fractions of Cr (15.22 ± 3.5 μg/g), Na (269.98 ± 25.01 μg/g), La (0.478 ± 0.041 μg/g), K (1.33 ± 0.23 μg/g), Br (1.2 ± 0.19 μg/g), As (0.697 ± 0.038) and Sb (66.09 ± 11.24 μg/g), were determined. This herb was collected from Taourirt Aden Berber village situated in Northern Algeria. Five elements were quantified in certified AIEA standards IAEA-V10 and IAEA-SL1 for checking the accuracy of our procedure. It was noteworthy the values obtained from this work are in good agreement with the certified values, the Z-score values for all elements were |Z| < 3. We believe that herb is natural and harmless compared with chemical drugs. Unfortunately the potential toxicity due to the Aristolochia Acids content has required the analysis of Aristolochia Longa by CG/MS and HPLC to highlight this compound. The standard of Aristolochic Acid (Sigma A5512-25 mg Yellow powder lot # wxbb6331VPCODE) was used as reference.
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Jordan, S. A., and S. Perwaiz. "Aristolochic Acids." In Encyclopedia of Toxicology, 298–301. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.01164-7.

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"Aristolochic Acid Nephropathy." In Diagnostic Pathology: Kidney Diseases, 660–61. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-323-37707-2.50148-8.

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Conference papers on the topic "Aristolochia acids"

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Yu, Li-Rong, Zhiguang Li, Yuan Gao, and Tao Chen. "Abstract LB-438: Proteomic analysis of aristolochic acid-induced nephrotoxicity in rats." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-438.

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Edwards, Karen L., Jia Yin Wang, Katherine Snappin, Zdenko Sonicki, Marcia Miletic-Medved, Arthur P. Grollman, and Bojan Jelakovic. "Abstract 1837: Exposure to Aristolochic Acid is associated with endemic (Balkan) nephropathy." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1837.

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Sidorenko, Viktoriya S., Kathleen G. Dickman, Thomas Rosenquist, Radha Bonala, Sivaprasad Attaluri, Irina Zaitseva, Charles Iden, Francis Johnson, and Arthur P. Grollman. "Abstract 5241: Using affinity probes to explore the nephrotoxicity of aristolochic acid." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5241.

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Alkawari, Fatima, Wigdan Ali, Fatiha Benslimane, and Huseyin Yalcin. "Investigating the Cardiac effects of New Generation Anti-Diabetic Drug Empagliflozin using Zebrafish Embryo Model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0211.

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Type 2 diabetes mellitus (T2DM) affects >16% of adults in Qatar. Newly emerging class of antidiabetic drugs focused on SGLT inhibition were observed to reduce CVDs risks in diabetic patients. Up to date, the mechanism contributing to the CV benefits remains unrevealed. Zebrafish embryos were treated with Aristolochic Acid to induce heart failure then treated with Empagliflozin to determine its beneficial effect. Furthermore the expression of SGLT1 & 2 were determined in the hearts of zebrafish. SGLT2 was expressed more then SGLT1 in the heart and whole embryo. Empa significantly improved the zebrafish embryo'scardiachealthafterinductionofheartfailure.
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Grollman, Arthur P. "Abstract PL02-02: Aristolochic acid-induced nephropathy and urothelial carcinoma: A preventable global disease." In Abstracts: Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; Oct 27-30, 2013; National Harbor, MD. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1940-6215.prev-13-pl02-02.

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Lo, Fang Yin, Charles Valentine, Elizabeth Schmidt, Lindsey Williams, Arnoud Boot, Steve Rozen, and Jesse Salk. "Abstract 3147: Non-invasive detection of aristolochic acid exposure using ultra-sensitive duplex sequencing." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3147.

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Rosenquist, Thomas A., Penelope Strockbine, and Arthur P. Grollman. "Abstract 3253: Genetic loci that contribute to aristolochic acid nephropathy and associated upper urothelial cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3253.

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Chen, Xiaoyi, Qinqin Chai, Xianghui Li, Jie Huang, and Wu Wang. "A Rapidly Method for the Discrimination of Aristolochic Acid and its Analogues Using SVM and PCA." In 2019 Chinese Control Conference (CCC). IEEE, 2019. http://dx.doi.org/10.23919/chicc.2019.8865305.

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Castells, Xavier, Sandra Karanovic, Magali Olivier, Maude Ardin, Florence Le Calvez-Kelm, Catherine Voegele, James McKay, et al. "Abstract 305: Ultra-low coverage exome sequencing of FFPE tumor specimens identifies exposure to carcinogenic aristolochic acid." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-305.

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Moussa, Heba Adel Mohamed Lotfy, Gawaher Saleh Abbas Mahgoub, Mashael Ali H. I. Al-Badr, and Huseyin Cagatay Yalcin. "Investigating the Cardiac Effects of Sildenafil loaded Nanoparticles on Heart Failure using the Zebrafish Embryo Model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0217.

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Background: Cardiovascular diseases (CVDs) are the first cause of death worldwide. Vasolidator agents are used to relax cardiac muscle, but their extremely short half-lifes limit their effectiveness. Sildenafil is such an agent used to relax the blood vessels muscles and increase the blood flow. The conventional drug can lead to serious problems in patients duo to the systematic drug delivery. Use of Nanomedicine potentially can enhance delivery of this agent while reducing the systematic effect of the drug. Aim: The purpose of the research is to examine the effectiveness sildenafil loaded nanoparticles in rescuing heart failure using zebrafish embryo model. Methods: There will be five experimental groups. The zebrafish will be treated with Aristolochic Acid (AA) at 24 hour per fertilization (hpf) to create the heart injury group. The treatment groups will be heart injury followed by a dose of either Sildenafil or Sildenafil loaded nanoparticles at 36 hpf. Two control groups will be the negative control (exposed to egg water) and vehicle control (exposed to the Dimethylsulfoxide (DMSO)).To evaluate the drug effects on embryo, toxicity assessment (Survival rate, tail flicking and hatching rate), cardiotoxicity assessment and gene expression of heart injury marker via RT-PCR will be conducted. Results: Preliminary findings demonstrate, loading Sildenafil to nanoparticles enhances its effectiveness dramatically. The experiments are ongoing to confirm the results. Conclusion: Nanomedicine is a powerful approach to enhance cardiovascular therapy. Vasodilator drugs in particular will benefit from this improvement as demonstrated with our findings
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