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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

Yanagi, Takeru. Arc Volcano of Japan: Generation of Continental Crust from the Mantle. Tokyo: Springer-Verlag Berlin Heidelberg, 2011.

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2

Ėvoli͡u︡t͡s︡ii͡a︡ drevneĭ sialicheskoĭ kory v ostrovoduzhnykh sistemakh Vostochnoĭ Azii. Vladivostok: DVNT͡S︡ AN SSSR, 1985.

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3

Colour me girl crush. London: Portico, 2014.

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4

Ministral, Josep. Crist de l'olivera: El mural de Llers. Figueres [Spain]: Brau Edicions, 2014.

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5

Massana, Ramon Puig. El rostre de Jesús, el Crist: Passeig fenomenològic per dos mil anys d'iconografia cristològica. Barcelona: La Formiga d'Or, 1998.

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6

Curso de Verano sobre el Franciscanismo en Andalucía. El franciscanismo en Andalucía: El arte franciscano en las catedrales andaluzas : conferencias del VI Cruso de Verano (Priego de Córdoba, del 31 de julio al 5 de agosto de 2001). Córdoba: CajaSur, Obra Social y Cultural, 2005.

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7

Yanagi, Takeru. Arc Volcano of Japan: Generation of Continental Crust from the Mantle. Springer, 2011.

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8

Yanagi, Takeru. Arc Volcano of Japan: Generation of Continental Crust from the Mantle. Springer, 2016.

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9

Woodsworth, Glenn J., Margaret E. Rusmore, Harold H. Stowell, and Lincoln S. Hollister. Architecture and Evolution of the Crust during Continental Arc Magmatism: A Transect through the Coast Mountains Batholith, British Columbia. Geological Society of America, 2020. http://dx.doi.org/10.1130/fld058.

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Originally prepared for the GSA Thompson Field Forum that ran from Terrace to Prince Rupert, British Columbia, this guide describes the geology along the Skeena River transect of the Coast Mountains batholith, the largest Cordilleran batholith of western North America and one of the largest continental-margin batholiths in the world. The last guide to this area was published in 1983 and this new volume is the only modern overview of the last decades of work. The authors use the transect as a basis to examine the growth of the Coast Mountains batholith as a whole, emphasizing commonalities and variations with the batholith and how these traits may reflect magmatic processes that create convergent-margin batholiths.
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10

Schaefer, Lola M. Musty-Crust Animals ABC (Musty-Crusty Animals). Tandem Library, 2002.

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11

Musty-Crusty Animals ABC. Heinemann, 2002.

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12

Ellam, Rob. 10. Probing the Earth with isotopes. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198723622.003.0010.

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‘Probing the Earth with isotopes’ shows how, using isotopes, we have come to understand the structure and behaviour of the Earth. The outer few tens of kilometres are divided into continental and oceanic crust. Below the crust, the sub-surface is divided into the mantle and the core. From the base of the crust to about 2,800 km depth, the Earth is rocky and composed of minerals like olivine and pyroxene that are rich in magnesium, iron, and calcium. From about 2,800 km to about 5,100 km depth the outer core is liquid. The remaining 1,200 km or so to the centre of the Earth is solid metal.
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13

Negri, Paul. Japanese Animal and Floral Crest Designs. Dover Publications, Incorporated, 2012.

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14

Negri, Paul. Japanese Animal and Floral Crest Designs. Dover Publications, Incorporated, 2012.

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15

Negri, Paul. Japanese Animal and Floral Crest Designs. Dover Publications, 2007.

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16

Vaughan, David. 3. Minerals and the interior of the Earth. Oxford University Press, 2014. http://dx.doi.org/10.1093/actrade/9780199682843.003.0003.

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‘Minerals and the interior of the Earth’ looks at the role of minerals in plate tectonics during the processes of crystallization and melting. The size and range of minerals formed are dependent on the temperature and pressure of the magma during its movement through the crust. The evolution of the continental crust also involves granite formation and processes of metamorphism. Our understanding of the interior of the Earth is based on indirect evidence, mainly the study of earthquake waves. The Earth consists of concentric shells: a solid inner core; liquid outer core; a solid mantle divided into a lower mantle, a transition zone, and an upper mantle; and then the outer rigid lithosphere.
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17

Bouchez, Jean-Luc, and Adolphe Nicolas. Principles of Rock Deformation and Tectonics. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192843876.001.0001.

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This book, based on laboratory, teaching and field experience, has a strong focus towards hard rocks and magmatic rocks, from both the continental crust worldwide, where quartz and granites are dominant, and the mantle dominated by olivine in peridotites. With more than 250 figures, most of them original, the book develops, in addition to classical structural geology objects, the fundamentals of brittle fracturing of materials, plastic deformation of ice, quartz and olivine, and fabric acquisition in rocks and magmas. Measurement and orientation of stress axes, bases of neotectonics and geophysics, and practical tools such as magnetic fabrics not commonly treated in geological books, are also provided. Emblematic tectonic and geodynamic sites are presented, both from the oceanic and continental crust, for instance the Oman ophiolites, and the India-Eurasia collision and its associated shear zones. Since the targeted readers are present-day young students, a few structural geology exercises are also included in order to improve their abilities.
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18

Color Crush: An Adult Coloring Book, Premium Edition. PCG Publishing Group, 2016.

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19

Malyukova, N. N., and T. K. Ametova. Geology. Part 1. KRSU Publishing House, 2021. http://dx.doi.org/10.36979/978-9967-19-808-1-2021.

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The study guide summarizes modern information about the structure and composition of the Earth’s crust. The descriptions of endogenous and exogenous geological processes, the most important ore and rock-forming minerals, rocks, tectonic dislocations are given. Theoretical course introduces students to the geology of oil and gas, considers hypotheses of hydrocarbons origin, physical and chemical properties of oil and gas, conditions of formation of deposits and regularities of their location in the Earth’s crust. This material contributes to solving urgent problems of mining production and training highly qualified specialists in the field of design and development of mineral deposits. For students of higher educational institutions, studying in the field of training of diplomate specialists in «Mining». The applicable nature of the Guide makes it useful and intelligible for not only students, Ph. students and teachers, but for specialists of the mining and geological survey.
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20

Parker, Jordan. Harry Styles Coloring Book: Color Your Crush for Styler Fans. Made in Colors Publishers LLC, 2021.

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21

Sever, Mehmet Şükrü, and Raymond Vanholder. Acute kidney injury in polytrauma and rhabdomyolysis. Edited by Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0252_update_001.

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The term ‘polytrauma’ refers to blunt (or crush) trauma that involves multiple body regions or cavities, and compromises physiology to potentially cause dysfunction of uninjured organs. Polytrauma frequently affects muscles resulting in rhabdomyolysis. In daily life, it mostly occurs after motor vehicle accidents, influencing a limited number of patients; after mass disasters, however, thousands of polytrauma victims may present at once with only surgical features or with additional medical complications (crush syndrome). Among the medical complications, acute kidney injury (AKI) deserves special mention, since it is frequent and has a substantial impact on the ultimate outcome.Several factors play a role in the pathogenesis of polytrauma (or crush)-induced AKI: (1) hypoperfusion of the kidneys, (2) myoglobin-induced direct nephrotoxicity, and intratubular obstruction, and also (3) several other mechanisms (i.e. iron and free radical-induced damage, disseminated intravascular coagulation, and ischaemia reperfusion injury). Crush-related AKI is prerenal at the beginning; however, acute tubular necrosis may develop eventually. In patients with crush syndrome, apart from findings of trauma, clinical features may include (but are not limited to) hypotension, oliguria, brownish discoloration of urine, and other symptoms and findings, such as sepsis, acute respiratory distress syndrome, disseminated intravascular coagulation, bleeding, cardiac failure, arrhythmias, electrolyte disturbances, and also psychological trauma.In the biochemical evaluation, life-threatening hyperkalaemia, retention of uraemic toxins, high anion gap metabolic acidosis, elevated serum levels of myoglobin, and muscle enzymes are noted; creatine phosphokinase is very useful for diagnosing rhabdomyolysis.Early fluid administration is vital to prevent crush-related AKI; the rate of initial fluid volume should be 1000 mL/hour. Overall, 3–6 L are administered within a 6-hour period considering environmental, demographic and clinical features, and urinary response to fluids. In disaster circumstances, the preferred fluid formulation is isotonic saline because of its ready availability. Alkaline (bicarbonate-added) hypotonic saline may be more useful, especially in isolated cases not related to disaster, as it may prevent intratubular myoglobin, and uric acid plugs, metabolic acidosis, and also life-threatening hyperkalaemia.In the case of established acute tubular necrosis, dialysis support is life-saving. Although all types of dialysis techniques may be used, intermittent haemodialysis is the preferred modality because of medical and logistic advantages. Close follow-up and appropriate treatment improve mortality rates, which may be as low as 15–20% even in disaster circumstances. Polytrauma victims after mass disasters deserve special mention, because crush syndrome is the second most frequent cause of death after trauma. Chaos, overwhelming number of patients, and logistical drawbacks often result in delayed, and sometimes incorrect treatment. Medical and logistical disaster preparedness is useful to improve the ultimate outcome of disaster victims.
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22

Dyer, Laura A., and Margaret L. Kirby. The role of the neural crest in cardiac development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0019.

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The cardiac neural crest (CNC) plays pivotal roles in numerous steps of cardiac development. Every aspect of the CNC cell’s lifespan is highly orchestrated, from its induction in the dorsal neural tube to its migration to its differentiation at its final destination. During migration, CNC cells are affected by their environment and simultaneously modulate the extra-cellular milieu through which they migrate. In the pharyngeal arches, CNC cells repattern the originally symmetrical arch arteries, producing the great arteries. Because the cardiac neural crest is essential for many aspects of heart development, it is unsurprising that human CNC-related syndromes have severe phenotypes. This chapter describes how CNC cells are formed and contribute to their final destinations. Essential signalling pathways are presented in the context of CNC development, and CNC-related syndromes are included to highlight this population’s broad importance during development.
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23

Vaughan, David. 1. The mineral world. Oxford University Press, 2014. http://dx.doi.org/10.1093/actrade/9780199682843.003.0001.

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Minerals are the fundamental components of the Earth. ‘The mineral world’ describes the fields of mineralogy and crystallography that study them. There are approximately 4,400 known minerals, but the ‘big ten’ minerals that are most abundant in the rocks of the Earth’s crust and Upper Mantle are calcite, quartz, olivines, pyroxenes, amphiboles, muscovite, biotite, orthoclase, albite, and anorthite. The two essential characteristics of any mineral are its chemical composition and its crystal structure. Minerals can be assigned to one of seven crystal classes depending on their elements of symmetry. There is further subdivision into 32 crystal classes. Minerals are classified by chemical composition into mineral groups such as silicates, and carbonates.
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24

Vaughan, David. 7. Minerals past, present, and future. Oxford University Press, 2014. http://dx.doi.org/10.1093/actrade/9780199682843.003.0007.

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‘Minerals past, present, and future’ first considers a theory of mineral evolution that proposes the Earth has evolved through three eras subdivided into ten stages, with each adding to the total inventory of mineral species. They are the planetary accretion era (Stages 1 and 2), crust and mantle reworking era (Stages 3–5), and biologically mediated mineralogy era (Stages 6–10). What role did these minerals play in the emergence of life? Pressing concerns for the present and future are whether the Earth has enough mineral resources to support human life and the environmental impact of the extraction, processing, and utilization of mineral resources.
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25

Beed, Martin, Richard Sherman, and Ravi Mahajan. Renal. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199696277.003.0007.

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Fluid balance disordersAcute kidney injuryRhabdomyolysis/crush syndromeFluid balance disorders include hypovolaemia (oligaemia), dehydration/acute fluid depletion, and hypervolaemia/fluid overload. Careful attention to fluid balance is essential in ICU. Patients are likely to require ‘maintenance’ fluids in addition to any fluid resuscitation.Hypovolaemia (see also Shock, ...
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26

Arthur, Richard T. W. Atoms and Souls. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198812869.003.0004.

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This chapter is built around the resolution of an enigma: why do atoms feature so prominently in Leibniz’s earlier writings when indivisibility is precluded by actually infinite division, which he upheld even then? It is argued that Leibniz’s early atoms are divided within, under an impenetrable crust, and that he is heir to a rich chymical and medical tradition of atomism that conceives atoms as having internal complexity and as being united by forms. His attachment to this tradition is theologically motivated, as signalled by his early advocacy of traduction, and the appeal to atoms to guarantee the integrity and indestructibility of the soul.
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27

Calzada i Salavedra, Arcadi, aut., ed. El Crist romànic a les terres de Girona: Centre Cultural de Caixa de Girona, Fontana d'Or, Girona. Girona: Fundació Caixa de Girona, 2005.

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28

Rez, Peter. Materials That Come from the Earth. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198802297.003.0013.

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Many of the materials used are ultimately derived from things extracted from the earth. There is always an energy-intensive step of converting the oxide as found in the earth’s crust to the element or metal. Since carbon in the form of coke is frequently used in this process, it is inevitable that CO2 is emitted. Another thing to consider is the scarcity of the compound from which the element will be derived—that is, the grade of the ore. A low grade of ore, with little of the element of interest, will mean more energy will need to be used to dig up a greater quantity of material. Practically everything has gone through some form of high-temperature processing that contributes to its embodied energy. The embodied energy can be very high if extreme purity is demanded or if a low-abundance isotope is needed.
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29

Brown, Christina, and Meredith Kato. Neuroblastoma. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0033.

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Neuroblastoma is a solid tumor that arises from neural crest cells. It is a common cancer of childhood, accounting for 7.8% of all childhood malignancy. It affects primarily infants and toddlers with older children carrying a worse prognosis. While surgery is a primary treatment modality, these tumors are not well encapsulated and tend to invade adjacent structures making resection more difficult. As such, patients often come to the operating room after neoadjuvant chemotherapy and the surgeries can be long with large blood losses. Anesthesia for the resection for neuroblastoma must take into account the effect of ongoing treatment on the patients as well as the surgical challenges inherent in this disease.
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30

Harrison, John Henry, and Magdalena Anitescu. Neuraxial Anesthesia in Coexisting Neurologic Conditions. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0041.

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Some patients who need surgery may have coexisting neurologic disorders like multiple sclerosis, amyotrophic lateral sclerosis, peripheral neuropathies (e.g., Charcot-Marie-Tooth disease or Guillain-Barré syndrome), or muscular dystrophies (e.g., Duchenne’s or myotonic dystrophy). When neuraxial analgesia and anesthesia are indicated, the anesthesiologist should be aware of the risks and benefits of the technique. Neuraxial anesthesia is not absolutely contraindicated in nervous system diseases and there are undeniable benefits to ruling out general anesthesia. In patients with coexisting neurologic disorders, prolonged sensory and motor block can be confused with epidural hematoma and abscess when present. Minor nerve injury from local anesthetic cytotoxicity or ischemia and mechanical trauma may cause permanent nerve injury through the double crush phenomenon. Lower concentrations of local anesthetics are generally recommended.
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31

Bunch, Chris. Diagnosis and investigation in haematology. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0278.

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This chapter addresses the interpretation of the full blood count, blood film, bone marrow examination, and related tests in the diagnosis of haematological disorders. Examination of a stained blood film, which should always be requested if a blood count abnormality cannot readily be explained by the clinical context, may give clues to the cause of the abnormality or prove diagnostic. Examination of the bone marrow is essential to the proper evaluation and diagnosis of many haematological disorders. The simplest form of marrow examination involves needle aspiration of marrow cells from the posterior iliac crest; smears are made and stained in the same way as a blood film. Bone marrow can also be biopsied for histological examination, at the same time as marrow aspiration.
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32

Provenzano, David A. Lumbar Facet Nerve Block: Ultrasound. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0020.

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This chapter describes the relevant anatomy and sonoanatomy and the ultrasound-guided technique for lumbar medial branch blocks. The ultrasound-guided lumbar medial branch block is an intermediate level block. Prior to performing this block, it is important to have a detailed understanding of lumbar sonoanatomy in order to be able to target the correct level, the lumbar medial branch and the L5 dorsal ramus zones. In those individuals with body mass indexes in the ideal range, current studies suggest the L3 and L4 medial branches can be successfully targeted. The L5 dorsal ramus may be challenging secondary to the iliac crest, which may limit the ultrasound views needed for the target zone. Further technical and equipment advancements are needed to improve and reduce the existing limitations associated with the ultrasound-guided lumbar medial branch block technique.
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33

Janssen, Ted, Gervais Chapuis, and Marc de Boissieu. Aperiodic Crystals. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198824442.001.0001.

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Until the 1970s all materials studied consisted of periodic arrays of unit cells, or were amorphous. In the following decades a new class of solid state matter, called aperiodic crystals, has been found. It is a long-range ordered structure, but without lattice periodicity. It is found in a wide range of materials: organic and inorganic compounds, minerals (including a substantial portion of the earth’s crust), and metallic alloys, under various pressures and temperatures. Because of the lack of periodicity the usual techniques for the study of structure and physical properties no longer work, and new techniques have to be developed. This book deals with the characterization of the structure, the structure determination, and the study of the physical properties, especially the dynamical and electronic properties of aperiodic crystals. The treatment is based on a description in a space with more dimensions than three, the so-called superspace. This allows us to generalize the standard crystallography and to look differently at the dynamics. The three main classes of aperiodic crystals, modulated phases, incommensurate composites, and quasicrystals are treated from a unified point of view which stresses the similarities of the various systems. The book assumes as a prerequisite a knowledge of the fundamental techniques of crystallography and the theory of condensed matter, and covers the literature at the forefront of the field.
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34

Hintz, Lisel. Stuck Inside. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190655976.003.0005.

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This chapter analyzes the powerful function in practice of the institutions whose origin and nature are explored in the previous chapter. It conceptualizes institutions that are founded to protect principles related to identity, such as secularism, as institutional obstacles to challenges from supporters of competing identity proposals. The chapter examines the attempts of the explicitly Islamist Welfare Party (RP) to spread Ottoman Islamism in Turkey’s public sphere and to shift the country’s foreign policy toward the Middle East. The chapter then demonstrates how military, judicial, and educational institutions infused with Republican Nationalism functioned to crush the RP’s efforts. It focuses on the experiences of the RP, which was pushed out of power by Turkey’s National Security Council and closed by the Constitutional Court during the February 28 process. These served as lessons from whcih the AKP, whose roots lie in the RP, would learn to circumvent such domestic obstacles and contest Republican Nationalism abroad.
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35

Smith, Rebecca. Smallpox. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0063.

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Symptoms of the smallpox virus include fever and a progressive papular rash that becomes vesicular and then pustular. A systemic inflammatory response syndrome (SIRS) leads to septic shock and death in 30% of cases. The definitive diagnosis can be confirmed via blood samples, lesion contents, or scrapings from crusts analyzed using electron microscopy, viral antigen immunohistochemistry, or polymerase chain reaction. The suspicion of a single smallpox case should lead to immediate notification of local public health authorities and the hospital epidemiologist. Because the disease does not exist in nature, smallpox should be considered the result of a bioterrorist attack until proven otherwise. An epidemiologic investigation is essential for determining the perimeter of the initial release so that tracking and quarantine of those exposed can be completed. Patients are extremely contagious and must be placed on contact, droplet, and airborne precautions in a negative pressure room.
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36

Armstrong, Bruce K., Claire M. Vajdic, and Anne E. Cust. Melanoma. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0057.

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Melanoma is a cancer of melanocytes, cells that produce the brown-black skin pigment melanin. Melanocytes originate in cells of the neural crest and migrate during embryogenesis, principally to the epidermis, eyes, and some mucous membranes (mouth, nose, esophagus, anus, genitourinary organs, and conjunctiva). Cutaneous melanoma afflicts mainly fair-skinned people of European origin, among whom sun exposure is the major cause. Five-year relative survival can exceed 90%. Invasive cutaneous melanoma in US whites occurs mostly on the trunk (34%), and upper limbs and shoulders (26%). Melanoma incidence rates have been increasing predominantly in European-origin populations. Ultraviolet (UV) radiation, from the sun or artificial tanning devices, probably both initiates and promotes melanoma. Nevi are markers of increased melanoma risk and direct precursors in some cases; nevus-prone people may require only modest sun exposure to initiate melanoma. Other risk factors include family history and sun sensitivity.
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37

Trela-Kieferling, Elżbieta, ed. Nakopalniane pracownie krzemieniarskie z okresu neolitu w Bęble, stan. 4, woj. małopolskie / Neolithic flint workshops at the mine in Bębło, site 4, Małopolska. Muzeum Archeologiczne w Krakowie; Wydawnictwo Profil-Archeo, 2021. http://dx.doi.org/10.33547/bmak.10.

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The flint mine in Bębło is situated in the Ojców Upland within the Olkusz Upland, above the Kluczwoda, Bolechówka and Bębłówka river valleys. Its vast mining field lies on a slope of a crest facing south-east, rising above a small valley, now dry but once crossed by a watercourse, to a height of approx. 30 metres. In the late 5th millennium BC, irregular flint concretions were extracted there through small shallow pits located one next to the other and reaching the bottom of karst karren. The nature, function and relative chronology of Site 4 in Bębło are crucial to the analysis of flint mining and reduction techniques in southern Poland in the middle phase of the Lengyel culture. They can also prove useful in tracing the relationship between the local technological changes and the influx of new ideas linked with the “second stage of the Neolithization in the Polish territories”.
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38

Publishing, Emadyous. I'm Ready to Crush Pre-K : Letter Tracing, Coloring Book and ABC Activities for Preschoolers: 100 Pages of Letter Tracing and Coloring Book for Kids Ages 3 and up. Independently Published, 2020.

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39

Pearson, David. Rebel Music in the Triumphant Empire. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780197534885.001.0001.

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At the dawn of the 1990s, as the United States celebrated its victory in the Cold War and sole superpower status by waging war on Iraq and proclaiming democratic capitalism as the best possible society, the 1990s underground punk renaissance transformed the punk scene into a site of radical opposition to American empire. Nazi skinheads were ejected from the punk scene; apathetic attitudes were challenged; women, Latino, and LGBTQ participants asserted their identities and perspectives within punk; the scene debated the virtues of maintaining DIY purity versus venturing into the musical mainstream; and punks participated in protest movements from animal rights to stopping the execution of Mumia Abu-Jamal to shutting down the 1999 World Trade Organization meeting. Punk lyrics offered strident critiques of American empire, from its exploitation of the Third World to its warped social relations. Numerous subgenres of punk proliferated to deliver this critique, such as the blazing hardcore punk of bands like Los Crudos, propagandistic crust-punk/dis-core; grindcore and power violence with tempos over 800 BPM, and So-Cal punk with its combination of melody and hardcore. Musical analysis of each of these styles and the expressive efficacy of numerous bands reveals that punk is not merely simplistic three-chord rock music, but a genre that is constantly revolutionizing itself in which nuances of guitar riffs, vocal timbres, drum beats, and song structures are deeply meaningful to its audience, as corroborated by the robust discourse in punk zines.
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40

Rammah, Mayyasa, Francesca Rochais, and Robert G. Kelly. Incorporation of myocardial progenitors at the arterial pole of the heart. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0007.

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The arterial pole of the heart is a hotspot for life-threatening forms of congenital heart defects (CHDs). It is formed by progressive addition of myocardium from epithelial progenitor cells in the second heart field (SHF). SHF cells contribute successively to the right ventricle and proximal and distal outflow tract myocardial walls which, after neural crest influx and cardiac septation, give rise to myocardium at the base of the aorta and pulmonary trunk. SHF cells are characterized by continued proliferation and differentiation delay controlled by an array of transcriptional regulators and signalling pathways which define the SHF progenitor cell niche in pharyngeal mesoderm. Failure of normal SHF deployment leads to a shortened outflow tract and failure of ventriculo-arterial alignment, resulting in a spectrum of conotruncal CHD. We discuss the origins of the SHF in cardiopharyngeal mesoderm and focus on the mechanisms driving SHF deployment, summarizing current understanding of critical signalling pathways and transcription factors.
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41

Longmore, Murray, Ian B. Wilkinson, Andrew Baldwin, and Elizabeth Wallin. Reference intervals, etc. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199609628.003.0018.

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The Gaussian (‘Normal’) distributionDrug therapeutic ranges in plasmaGentamicinSome important drug interactionsHaematology reference intervalsBiochemistry reference intervalsOnce upon a time, in a famous hospital named R— in the middle of England, there lived a crusty old surgeon and a brilliant young house officer. The surgeon issued infallible and peremptory edicts such as “All my patients with a haemoglobin less than 100 must be transfused.” Everyone did as the surgeon said (this was a long time ago) except for the wily house officer who understood statistics, sampling error, and the play of chance. One day she was rung up by the haematologist who asked her “Why have you requested 3 blood counts on Mrs Wells today? One is enough. You are wasting our resources!” “Not so,” said the house officer. “The first Hb was 98, the second was 97 and the third was 101g/L. I knew if I was persistent, I stood a good chance of preventing an unnecessary transfusion. She is a patient of Mr X.” The two conspirators smiled at each other down the telephone, and no more was said. Of course the right way of dealing with this problem is through clinical governance and dialogue with the surgeon. But the point remains: numbers are elastic, despite, on occasion, being given to 3 decimal places. Don’t believe in them as absolute entities, and don’t believe that the normal range is anything other than arbitrary; think before you act: think statistically. ...
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42

Metzinger, Thomas, and Jennifer M. Windt, eds. Open MIND, 2-vol. set. The MIT Press, 2016. http://dx.doi.org/10.7551/mitpress/10603.001.0001.

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A unique interdisciplinary collection of papers and commentaries by leading researchers and rising scholars, representing the latest research on consciousness, mind, and brain. This collection offers the most comprehensive collection on consciousness, brain, and mind available. It gathers 39 original papers by leaders in the field followed by commentaries written by emerging scholars and replies by the original paper's authors. Taken together, the papers, commentaries, and replies provide a cross-section of cutting-edge research in philosophy and cognitive science. Open MIND is an experiment in both interdisciplinary and intergenerational scholarship. Open MIND grows out of the MIND Group, an independent, international body of young philosophers and scientists with a strong interest in the mind, consciousness, and cognition. The original and supporting materials are available online at open-mind.net. Authors includeMichael L. Anderson, Andreas Bartels, Tim Bayne, Christian Beyer, Ned Block, Paul M. Churchland, Andy Clark, Carl S. Craver, Holk Cruse, Daniel C. Dennett, Jérôme Dokic, Chris Eliasmith, Kathinka Evers, Vittorio Gallese, Philip Gerrans, Rick Grush, John-Dylan Haynes, Heiko Hecht, J. Allan Hobson, Jakob Hohwy, Pierre Jacob, J. Scott Jordan, Victor Lamme, Bigna Lenggenhager, Caleb Liang, Richard Menary, Albert Newen, Alva Noë, Gerard O'Brien, Elisabeth Pacherie, Jesse Prinz, Joëlle Proust, Antti Revonsuo, Adina Roskies, Jonathan Schooler, Anil K. Seth, Wolf Singer, Evan Thompson, Ursula Voss, Kenneth Williford
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