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Giannetta, Noemi, Giulia Villa, Federico Pennestrì, Roberta Sala, Roberto Mordacci, and Duilio Fiorenzo Manara. "Ethical Problems and Moral Distress in Primary Care: A Scoping Review." International Journal of Environmental Research and Public Health 18, no. 14 (July 16, 2021): 7565. http://dx.doi.org/10.3390/ijerph18147565.
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Background: Since 1997, nursing ethics research has focused on solving ethical dilemmas, enhancing decision-making strategies, and introducing professional education. Few studies describe the triggers of ethical dilemmas among primary care nurses. The aim of this study was to explore the moral distress and ethical dilemmas among primary care nurses. Methods: A scoping review was performed following Arskey and O’Malley’s framework. PubMed, CINAHL, PsycINFO, Embase, and Scopus were searched systematically to retrieve relevant titles and abstracts. A temporal filter was applied to focus on the most recent literature (years of 2010–2020). The research was completed on 17 November 2020. Results: Of 184 articles retrieved, 15 were included in the review. Some (n = 7) studies had a qualitative design, and the most productive country was Brazil (n = 7). The total number of nurses involved in quantitative studies was 1137 (range: 36–433); the total number of nurses involved in qualitative studies was 144 (range: 7–73). Three main focus areas were identified: (a) frequent ethical conflicts and moral distress episodes among nurses working in primary care settings; (b) frequent moral distress measures here employed; (c) coping strategies here adopted to prevent or manage moral distress. Conclusion: Further research is needed to examine the differences between moral distress triggers and sources of ethical dilemmas among the different care environments, such as primary care and acute care settings.
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Тарабань, Роман, Кодуру Лакшмоджі, Марк ЛаКур, and Філіп Маршалл. "Finding a Common Ground in Human and Machine-Based Text Processing." East European Journal of Psycholinguistics 5, no. 1 (June 30, 2018): 83–91. http://dx.doi.org/10.29038/eejpl.2018.5.1.tar.
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Language makes human communication possible. Apart from everyday applications, language can provide insights into individuals’ thinking and reasoning. Machine-based analyses of text are becoming widespread in business applications, but their utility in learning contexts are a neglected area of research. Therefore, the goal of the present work is to explore machine-assisted approaches to aid in the analysis of students’ written compositions. A method for extracting common topics from written text is applied to 78 student papers on technology and ethics. The primary tool for analysis is the Latent Dirichlet Allocation algorithm. The results suggest that this machine-based topic extraction method is effective and supports a promising prospect for enhancing classroom learning and instruction. The method may also prove beneficial in other applied applications, like those in clinical and counseling practice.
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Taraban, R., Marcy, W. M., LaCour Jr., M. S., & Burgess II, R. A. (2017). Developing machine-assisted analysis of engineering students’ ethics course assignments. Proceedings of the American Society of Engineering Education (ASEE) Annual Conference, Columbus, OH. https://www.asee.org/public/conferences/78/papers/19234/view.
Taraban, R., Marcy, W. M., LaCour, M. S., Pashley, D., & Keim, K. (2018). Do engineering students learn ethics from an ethics course? Proceedings of the American Society of Engineering Education – Gulf Southwest (ASEE-GSW) Annual Conference, Austin, TX. http://www.aseegsw18.com/papers.html.
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Eglīte, Ance, Linda Pudnika, Marta Anda Balode, and Anda Prikšāne. "Synthesis of Symmetric Ethers Using Monocationic and Dicationic Acidic Ionic Liquids." Key Engineering Materials 762 (February 2018): 104–8. http://dx.doi.org/10.4028/www.scientific.net/kem.762.104.
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A series of monocationic and dicationic -SO3H functionalized Brønsted acidic ionic liquids (BAILs) are synthesized using different amines int.al., N,N,N′,N′-tetramethylethylenediamine, 1-methylimidazole, pyridine and alkylating agents 1,3-propane- and 1,4-butanesultones. The Hammett acidity (H0) and thermal properties by TG-DSC techniques are investigated. These ionic liquids have been applied to catalyze the dehydration reaction of aliphatic long chain alcohols (1-heptanol, 1-octanol, 1-decanol) at 195 °C. The optimization of reaction conditions and use of dicationic ionic liquids allow to reach rather high yields of symmetric diheptyl ether and dioctyl ether. The reusability of ionic liquids is evaluated using monocationic [PyPS][HSO4], dicationic [TMEDAPS][HSO4] ionic liquids and 1-heptanol.
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Pereira, Victoria Quadros, Carine Panke, Leticia Eifler, Cristiane Tovo, and Thaís Moreira. "Association Between Hepatic Steatosis and Metabolic Syndrome in Patients With Non-alcoholic Fatty Liver Disease." Current Developments in Nutrition 5, Supplement_2 (June 2021): 858. http://dx.doi.org/10.1093/cdn/nzab047_021.
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Abstract Objectives Evaluate the association between the degree of hepatic steatosis and the development of metabolic syndrome in outpatients care. Methods Prospective cross-sectional study with outpatients care at the Gastroenterology Service of a hospital in southern Brazil. The study was approved by the Ethics Committee with protocol 57,328,416.8.0000.5335. Patients aged over 18 years and with non-alcoholic fatty liver disease were included. Patients were excluded from hepatitis B and C, with significant alcohol consumption and hepatocellular carcinoma. Data collection occurred during nutritional consultations, where we collected data of age, gender, lifestyle, diagnosis of comorbidities and biochemical tests. The result of liver biopsy was evaluated for the degree of hepatic steatosis. Anthropometric parameters were assessed for the diagnosis of metabolic syndrome, in addition to electrical bioimpedance for body composition. Data were presented as mean, median, standard deviation, interquartile range and percentages according to distribution. Student T, ANOVA and Pearson correlation tests were applied. The significance level was 5%. Results We evaluated 71 patients with mean age 59.08 ± 8.92 years, 67.6% (n = 48) women, 60.6% (n = 43) sedentary, 52.2% (n = 37) no smoking and mean body mass index of 32.91 ± 5.27 kg/m2. Systemic arterial hypertension were diagnosed in 80.3% (n = 57), 73.2% (n = 52) were diabetic, 66.2% (n = 47) were dyslipidemic and 28.2% (n = 20) of patients with metabolic syndrome. As liver biopsy, 25.4% (n = 18) mild steatosis, 23.9% (n = 17) moderate and 26.8% (n = 19) intense. In the comparison between the levels of hepatic steatosis and the variables, it was observed that patients with severe steatosis had metabolic syndrome (p = 0.041). Patients with metabolic syndrome have higher fat mass (p = 0.044), diastolic blood pressure (p = 0.019) and higher levels of serum triglycerides (p = 0.043). Severe hepatic steatosis correlated with the diagnosis of metabolic syndrome (r = 0.319; p = 0.019). Conclusions Severe hepatic steatosis is related to the diagnosis of metabolic syndrome.Patients with metabolic syndrome had a higher amount of fat mass, increased diastolic blood pressure and serum triglycerides. Funding Sources This study was not funded.
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Diomedi Camassei, F., H. P. McDowell, M. A. De Ioris, P. Altavista, R. Cozza, A. Donfrancesco, A. Inserra, F. Callea, and C. Dominici. "Clinical significance of CXC chemokine receptor-4 (CXCR4) and c-Met in childhood rhabdomyosarcoma (RMS) tumors." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 9510. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9510.
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9510 Background: Both CXCR4/SDF-1 and c-Met/HGF axes promote invasive growth of RMS cells in experimental models, but no data are available on their expression and significance in RMS tumors. Expression for CXCR4 and c-Met (and their ligands) was evaluated in primary RMS tumors and correlated with clinical features, marrow involvement at diagnosis, overall (OS) and progression-free survival (PFS). Methods: Forty newly diagnosed pts, aged 2–180 months (median 58), with embryonal (n. 20) or alveolar (n. 20) RMS admitted between 1994 and 2004 were retrospectively enrolled. The only selection criterion was availability of data on marrow involvement at diagnosis as assessed by cytomorphology and immunocytochemistry for MyoD1 and myogenin. Primary site was favorable (orbit, paratesticular, uterus/vagina) in 7 pts and unfavorable (all the others) in 33. Pts were entered as group I/II (n. 5), III (n. 28) or IV (n. 7) (IRS grouping system). Marrow was infiltrated at diagnosis in 16 pts. Treatment was according to Italian RMS protocols. Expression for CXCR4, SDF-1, c-Met and HGF proteins was investigated by immunohistochemistry. Three separate counts (each >5,000 tumor cells) were performed without knowledge of clinical features and outcome; results expressed as mean percentage of immunostained tumor cells. Student t test, log-rank test, Kaplan-Meier survival analysis were applied. Institutional informed consent and ethical approval were obtained. Results: As of December 2006, median follow-up was 60 months, with 25 pts DF, 1 AWD and 14 DOD. CXCR4 and c-Met were expressed in =5% of tumor cells in all cases, but 14/40 tumors showed =50% tumor cell positivity (high expression) for either markers. High CXCR4 expression correlated with alveolar histology (p=0.006), unfavorable primary site (p=0.009), advanced group (p<0.001), marrow involvement (p=0.007), shorter OS and PFS (p<0.001). High c- Met expression with alveolar histology (p=0.005), advanced group (p=0.04), marrow involvement (p=0.02). SDF-1 and HGF were expressed by a lower percentage of tumor cells (1–95% of cells positive for the correspondent receptor). Conclusions: CXCR4/SDF-1 and c-Met/HGF pathways are clinically relevant in children with RMS and represent novel targets for disease-directed therapy. No significant financial relationships to disclose.
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Jahnke, Linda L., Wolfgang Eder, Robert Huber, Janet M. Hope, Kai-Uwe Hinrichs, John M. Hayes, David J. Des Marais, Sherry L. Cady, and Roger E. Summons. "Signature Lipids and Stable Carbon Isotope Analyses of Octopus Spring Hyperthermophilic Communities Compared with Those ofAquificales Representatives." Applied and Environmental Microbiology 67, no. 11 (November 1, 2001): 5179–89. http://dx.doi.org/10.1128/aem.67.11.5179-5189.2001.
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ABSTRACT The molecular and isotopic compositions of lipid biomarkers of cultured Aquificales genera have been used to study the community and trophic structure of the hyperthermophilic pink streamers and vent biofilm from Octopus Spring. Thermocrinis ruber, Thermocrinis sp. strain HI 11/12,Hydrogenobacter thermophilus TK-6,Aquifex pyrophilus, and Aquifex aeolicusall contained glycerol-ether phospholipids as well as acyl glycerides. The n-C20:1 andcy-C21 fatty acids dominated all of theAquificales, while the alkyl glycerol ethers were mainly C18:0. These Aquificales biomarkers were major constituents of the lipid extracts of two Octopus Spring samples, a biofilm associated with the siliceous vent walls, and the well-known pink streamer community (PSC). Both the biofilm and the PSC contained mono- and dialkyl glycerol ethers in which C18 and C20 alkyl groups were prevalent. Phospholipid fatty acids included both the Aquificales n-C20:1 andcy-C21, plus a series ofiso-branched fatty acids (i-C15:0 toi-C21:0), indicating an additional bacterial component. Biomass and lipids from the PSC were depleted in13C relative to source water CO2 by 10.9 and 17.2‰, respectively. The C20–21 fatty acids of the PSC were less depleted than the iso-branched fatty acids, 18.4 and 22.6‰, respectively. The biomass of T. rubergrown on CO2 was depleted in 13C by only 3.3‰ relative to C source. In contrast, biomass was depleted by 19.7‰ when formate was the C source. Independent of carbon source, T. ruber lipids were heavier than biomass (+1.3‰). The depletion in the C20–21 fatty acids from the PSC indicates thatThermocrinis biomass must be similarly depleted and too light to be explained by growth on CO2. Accordingly,Thermocrinis in the PSC is likely to have utilized formate, presumably generated in the spring source region.
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Holý, Antonín, Ivan Rosenberg, and Hana Dvořáková. "Synthesis of (3-hydroxy-2-phosphonylmethoxypropyl) derivatives of heterocyclic bases." Collection of Czechoslovak Chemical Communications 54, no. 9 (1989): 2470–501. http://dx.doi.org/10.1135/cccc19892470.
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Analogs of the antiviral 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA, I), containing modified heterocyclic base, were prepared from racemic or (S)-N-(2,3-dihydroxypropyl) derivatives II. Compounds II are heated with chloromethylphosphonyl dichloride (XVII), the formed chloromethylphosphonylester chlorides of compounds II react with water to give a mixture of 2'- and 3'-chloromethylphosphonyl derivatives XVIII and XIX, respectively, which on isomerization by boiling with water in the arising acidic medium affords predominantly the 3'-isomer XIX. Treatment of this isomeric mixture with aqueous sodium hydroxide yields a mixture of 2'-O-phosphonylmethyl ethers (predominating, XXI) and 3'-O-phosphonylmethyl ethers of compounds II (XX). This approach has been applied to the synthesis of isomeric mixtures in the racemic as well as in the (S)-series derived from C-2, C-8 and N-6 substituted derivatives of adenine, from hypoxanthine and additional 6-substituted derivatives of purine, from guanine, 3-deazaadenine and other modified purine bases, from uracil, cytosine, their 5-methyl derivatives and 5-fluorouracil. Regioselective synthesis of compounds XXI was performed for biologically active derivatives (derivative of 2-aminoadenine (XXIe), guanine (XXIn), 3-deazaadenine (XXIp) and cytosine (XXIt)) as well as some other compounds (derivative of hypoxanthine (XXIj), uracil (XXIr), thymine (XXIs) and 5-methylcytosine (XXIu)): the former were obtained either from 3'-O-chloromethylphosphonyl derivatives XIX, isolated from the above-mentioned mixtures by ion-exchanger chromatography or HPLC, or by regioselective substitution, whereas the latter compounds were prepared by deamination (compound XXIj from adenine derivative I or the uracil and thymine derivatives XXIr and XXIu from the cytosine derivatives XXIt and XXIu). N-(S)-(3-Hydroxy-2-benzoyloxypropyl) derivative of N4-benzoylcytosine (XXIX) and N2-benzoylguanine (XXIV), obtained from compounds IIn and IIt by successive N-benzoylation, reaction with dimethoxytrityl chloride, benzoylation and mild acid treatment, were subjected to reaction with the chloride XVII and subsequent neutral and alkaline hydrolysis (compound XXIV), or to reaction with sodium methoxide followed by treatment with bromotrimethylsilane (compound XXIX), being thus converted into 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (XXIt, HPMPC) and 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)guanine (XXIn, HPMPG), respectively. The starting compounds (S)-II were synthesized from sodium salt of the corresponding heterocyclic base by reaction with 1-O-p-toluenesulfonyl-2,3-O-isopropylidene-(R)-glycerol (IIIa) (the (RS)-derivatives by reaction with 4-chloromethyl-2,2-dimethyl-1,3-dioxolane (IIIb)), followed by acid hydrolysis.
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Schuster, Judith, Jessica Purswani, Uta Breuer, Clementina Pozo, Hauke Harms, Roland H. Müller, and Thore Rohwerder. "Constitutive Expression of the Cytochrome P450 EthABCD Monooxygenase System Enables Degradation of Synthetic Dialkyl Ethers in Aquincola tertiaricarbonis L108." Applied and Environmental Microbiology 79, no. 7 (January 25, 2013): 2321–27. http://dx.doi.org/10.1128/aem.03348-12.
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ABSTRACTInRhodococcus ruberIFP 2001,Rhodococcus zopfiiIFP 2005, andGordoniasp. strain IFP 2009, the cytochrome P450 monooxygenase EthABCD catalyzes hydroxylation of methoxy and ethoxy residues in the fuel oxygenates methyltert-butyl ether (MTBE), ethyltert-butyl ether (ETBE), andtert-amyl methyl ether (TAME). The expression of the IS3-type transposase-flankedethgenes is ETBE dependent and controlled by the regulator EthR (C. Malandain et al., FEMS Microbiol. Ecol. 72:289–296, 2010). In contrast, we demonstrated by reverse transcription-quantitative PCR (RT-qPCR) that the betaproteobacteriumAquincola tertiaricarbonisL108, which possesses theethABCDgenes but lacksethR, constitutively expresses the P450 system at high levels even when growing on nonether substrates, such as glucose. The mutant strainA. tertiaricarbonisL10, which is unable to degrade dialkyl ethers, resulted from a transposition event mediated by a rolling-circle IS91-type element flanking theethgene cluster in the wild-type strain L108. The constitutive expression of Eth monooxygenase is likely initiated by the housekeeping sigma factor σ70, as indicated by the presence in strain L108 of characteristic −10 and −35 binding sites upstream ofethAwhich are lacking in strain IFP 2001. This enables efficient degradation of diethyl ether, diisopropyl ether, MTBE, ETBE, TAME, andtert-amyl ethyl ether (TAEE) without any lag phase in strain L108. However, ethers with larger residues,n-hexyl methyl ether, tetrahydrofuran, and alkyl aryl ethers, were not attacked by the Eth system at significant rates in resting-cell experiments, indicating that the residue in the ether molecule which is not hydroxylated also contributes to the determination of substrate specificity.
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Murray, Elizabeth, Jamie Ross, Kingshuk Pal, Jinshuo Li, Charlotte Dack, Fiona Stevenson, Michael Sweeting, et al. "A web-based self-management programme for people with type 2 diabetes: the HeLP-Diabetes research programme including RCT." Programme Grants for Applied Research 6, no. 5 (September 2018): 1–242. http://dx.doi.org/10.3310/pgfar06050.
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Background In the UK, 6% of the UK population have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Diabetes mellitus accounts for 10% of NHS expenditure (£14B annually). Good self-management may improve health outcomes. NHS policy is to refer all people with T2DM to structured education, on diagnosis, to improve their self-management skills, with annual reinforcement thereafter. However, uptake remains low (5.6% in 2014–15). Almost all structured education is group based, which may not suit people who work, who have family or other caring commitments or who simply do not like group-based formats. Moreover, patient needs vary with time and a single education session at diagnosis is unlikely to meet these evolving needs. A web-based programme may increase uptake. Objectives Our aim was to develop, evaluate and implement a web-based self-management programme for people with T2DM at any stage of their illness journey, with the goal of improving access to, and uptake of, self-management support, thereby improving health outcomes in a cost-effective manner. Specific objectives were to (1) develop an evidence-based theoretically informed programme that was acceptable to patients and health-care professionals (HCPs) and that could be readily implemented within routine NHS care, (2) determine the clinical effectiveness and cost-effectiveness of the programme compared with usual care and (3) determine how best to integrate the programme into routine care. Design There were five linked work packages (WPs). WP A determined patient requirements and WP B determined HCP requirements for the self-management programme. WP C developed and user-tested the Healthy Living for People with type 2 Diabetes (HeLP-Diabetes) programme. WP D was an individually randomised controlled trial in primary care with a health economic analysis. WP E used a mixed-methods and case-study design to study the potential for implementing the HeLP-Diabetes programme within routine NHS practice. Setting English primary care. Participants People with T2DM (WPs A, D and E) or HCPs caring for people with T2DM (WPs B, C and E). Intervention The HeLP-Diabetes programme; an evidence-based theoretically informed web-based self-management programme for people with T2DM at all stages of their illness journey, developed using participatory design principles. Main outcome measures WPs A and B provided data on user ‘wants and needs’, including factors that would improve the uptake and accessibility of the HeLP-Diabetes programme. The outcome for WP C was the HeLP-Diabetes programme itself. The trial (WP D) had two outcomes measures: glycated haemoglobin (HbA1c) level and diabetes mellitus-related distress, as measured with the Problem Areas in Diabetes (PAID) scale. The implementation outcomes (WP E) were the adoption and uptake at clinical commissioning group, general practice and patient levels and the identification of key barriers and facilitators. Results Data from WPs A and B supported our holistic approach and addressed all areas of self-management (medical, emotional and role management). HCPs voiced concerns about linkage with the electronic medical records (EMRs) and supporting patients to use the programme. The HeLP-Diabetes programme was developed and user-tested in WP C. The trial (WP D) recruited to target (n = 374), achieved follow-up rates of over 80% and the intention-to-treat analysis showed that there was an additional improvement in HbA1c levels at 12 months in the intervention group [mean difference –0.24%, 95% confidence interval (CI) –0.44% to –0.049%]. There was no difference in overall PAID score levels (mean difference –1.5 points, 95% CI –3.9 to 0.9 points). The within-trial health economic analysis found that incremental costs were lower in the intervention group than in the control group (mean difference –£111, 95% CI –£384 to £136) and the quality-adjusted life-years (QALYs) were higher (mean difference 0.02 QALYs, 95% CI 0.000 to 0.044 QALYs), meaning that the HeLP-Diabetes programme group dominated the control group. In WP E, we found that the HeLP-Diabetes programme could be successfully implemented in primary care. General practices that supported people in registering for the HeLP-Diabetes programme had better uptake and registered patients from a wider demographic than those relying on patient self-registration. Some HCPs were reluctant to do this, as they did not see it as part of their professional role. Limitations We were unable to link the HeLP-Diabetes programme with the EMRs or to determine the effects of the HeLP-Diabetes programme on users in the implementation study. Conclusions The HeLP-Diabetes programme is an effective self-management support programme that is implementable in primary care. Future work The HeLP-Diabetes research team will explore the following in future work: research to determine how to improve patient uptake of self-management support; develop and evaluate a structured digital educational pathway for newly diagnosed people; develop and evaluate a digital T2DM prevention programme; and the national implementation of the HeLP-Diabetes programme. Trial registration Research Ethics Committee reference number 10/H0722/86 for WPs A–C; Research Ethics Committee reference number 12/LO/1571 and UK Clinical Research Network/National Institute for Health Research (NIHR) Portfolio 13563 for WP D; and Research Ethics Committee 13/EM/0033 for WP E. In addition, for WP D, the study was registered with the International Standard Randomised Controlled Trial Register as reference number ISRCTN02123133. Funding details This project was funded by the NIHR Programme Grants for Applied Research programme and will be published in full in Programme Grants for Applied Research; Vol. 6, No. 5. See the NIHR Journals Library website for further project information.
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Groen, S. S., S. Holm Nielsen, A. C. Bay-Jensen, M. Rasti, D. Ganatra, K. Oikonomopoulou, and V. Chandran. "POS1097 BIOMARKERS OF INFLAMMATION AND JOINT TISSUE TURNOVER CAN HELP IMPROVING THE DIFFERENTIATION BETWEEN OSTEOARTHRITIS AND PSORIATIC ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 876.1–876. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4605.
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BackgroundOsteoarthritis (OA) is a slow progressive disease characterized by degeneration within the joint cartilage, leading to destruction and dysfunction of the involved joints. Psoriatic arthritis (PsA) is a chronic inflammatory disease manifesting itself in skin lesions and progressive inflammatory changes within the musculoskeletal system, leading to joint damage and functional limitation. Although OA and PsA are considered to be distinct diseases, they share overlapping clinical and inflammatory features that can cause diagnostic challenges. Throughout these inflammatory and degenerative processes in the joint tissues, proteases hold a major role in remodelling of the extracellular matrix (ECM) which results in protein breakdown products released into the synovial fluid (SF). These protein fragments can be quantified in SF as biomarkers of tissue remodelling and may be helpful in characterizing disease-specific or overlapping pathologies between OA and PsA.ObjectivesOur aim of this study is to measure biomarkers of inflammation and joint tissue turnover in SF to explore the distinct and overlapping pathologies between OA and PsA.MethodsSF samples were collected from patients with OA (n=54, mean ±SD age 62.1 ±11.9, 48% female) and patients with PsA (n=59, mean ±SD age 47.8±13.3, 37% female) recruited through Toronto Western Hospital, Canada. Study was approved by the local ethics committee. Biomarkers of inflammation reflecting macrophage activity (VICM) and neutrophil activity (CPa9-HNE) were measured in the SF samples. Moreover, ECM remodelling was assessed in the SF samples by biomarkers quantifying type II collagen formation (PRO-C2), fibronectin turnover (FBN-C), and aggrecan degradation (ARGS). Data were log-transformed and presented as mean ± standard deviation (SD). An ANCOVA corrected for age was applied to test the difference between biomarker levels across the two patient groups and a p-value below 0.05 was considered significant. Area under the receiver operating characteristic (ROC) curve (AUC) analysis was performed to describe the discrimination accuracy of each biomarker between the two patient groups.ResultsPsA patients presented significantly higher levels of macrophage; VICM, activity compared to OA (p<0.001, Figure 1A). On the other hand, OA patients demonstrated increased type II collagen formation and aggrecan degradation compared to PsA (p<0.001, Figure 1C, E). Interestingly, no significant difference in biomarkers levels of neutrophil activity and fibronectin remodelling was observed between the two disease groups. Moreover, VICM, PRO-C2, and ARGS showed high distributional difference between OA and PsA patients with an AUROC=0.915 (p<0.001, Figure 1F), AUROC=0.737 (p<0.001, Figure 1G), and AUROC=0.725 (p<0.001, Figure 1H), respectively.ConclusionPsA patients demonstrated higher macrophage activity in the SF compared to the OA patients, while higher levels of cartilage formation and degradation were observed in OA patients compared to PsA. No differences between OA and PsA were observed in neutrophil activity and fibronectin turnover, which may mirror the clinical difficulty in telling the two arthritides apart. Identifying the unique characteristics of the pathological processes underlying the two diseases may improve diagnosis and allow for the precise management of both OA and PsA patients.Disclosure of InterestsSolveig Skovlund Groen: None declared, Signe Holm Nielsen Employee of: Signe is employed by Nordic Bioscience, Anne-Christine Bay-Jensen Shareholder of: Anne C. Bay-Jensen holds stock in Nordic Bioscience, Employee of: Anne C. Bay-Jensen is employed by Nordic Bioscience, Mozhgan Rasti: None declared, Darshini Ganatra: None declared, Katerina Oikonomopoulou: None declared, Vinod Chandran: None declared
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Lee, Lip Kim, and Jianzhong He. "Reductive Debromination of Polybrominated Diphenyl Ethers by Anaerobic Bacteria from Soils and Sediments." Applied and Environmental Microbiology 76, no. 3 (December 11, 2009): 794–802. http://dx.doi.org/10.1128/aem.01872-09.
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ABSTRACT Polybrominated diphenyl ethers (PBDEs) have attracted attention recently due to their proven adverse effects on animals and their increasing concentrations in various environmental media and biota. To gain insight into the fate of PBDEs, microcosms established with soils and sediments from 28 locations were investigated to determine their debromination potential with an octa-brominated diphenyl ether (octa-BDE) mixture consisting of hexa- to nona-BDEs. Debromination occurred in microcosms containing samples from 20 of the 28 locations when they were spiked with octa-BDE dissolved in the solvent trichloroethene (TCE), which is a potential cosubstrate for stimulating PBDE debromination, and in microcosms containing samples from 11 of the 28 locations when they were spiked with octa-BDE dissolved in nonane. Debromination products ranging from hexa- to mono-BDEs were generated within 2 months. Notably, the toxic tetra-BDEs accounted for 50% of the total product. In sediment-free culture C-N-7* amended with the octa-BDE mixture and nonane (containing 45 nM nona-BDE, 181 nM octa-BDEs, 294 nM hepta-BDE, and 19 nM hexa-BDE) there was extensive debromination of the parent compounds, which produced hexa-BDE (56 nM), penta-BDEs (124 nM), and tetra-BDEs (150 nM) within 42 days, possibly by a metabolic process. A 16S rRNA gene-based analysis revealed that Dehalococcoides species were present in 11 of 14 active microcosms. However, unknown debrominating species in some of the microcosms debrominated the octa-BDE mixture in the absence of other added halogenated electron acceptors (such as TCE). These findings provide information that is useful for assessing microbial reductive debromination of higher brominated PBDEs to less-brominated congeners, a possible source of the more toxic congeners (e.g., penta- and tetra-BDEs) detected in the environment.
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Al-Jafar, Hassan A., Leena M. Aytoglu, Issa Loutfi, Iman Al-Shemmari, and Salem H. Alshemmari. "The Red Cell Mass (RCM) Value In Polycythaemia Vera Disease In The JAK2 V617F Era." Blood 122, no. 21 (November 15, 2013): 5249. http://dx.doi.org/10.1182/blood.v122.21.5249.5249.
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Abstract Introduction In Polycythaemia Vera (PV), the RBC lineage is involved with increased haemoglobin, RBC count and haematocrit. WHO diagnostic criteria for PV are JAK2 V617F mutation and elevated red cell mass (RCM) > 25% of mean normal value. In addition, tests of marrow hypercellularity, blood erythropoietin and colony formation, are minor criteria. However, the diagnostic role of RCM test is still controversial and requires clarification. In this work, PV patients who had both an RCM study and JAK2 V617F mutation test, and routine laboratory tests, are evaluated to check if RCM was essential in the diagnostic work up for PV. Methods Over 2 years, 75 patients with abnormal haematocrit (men ≥ 0.50, women ≥ 0.45) had RCM and JAK2 V617F mutation tests (except JAK2 exon 12 mutation). All subjects consented to the study approved by the ethics committee. RCM was done by Cr-51 RBC radiolabeling method (no prior venesection at least 1 month). Statistical analysis involved descriptive statistics and chi-square test. Results There were 71 males and 4 females, mean age 46 y (range 17-75 y). Increased RCM was found in 41/75 (55%). Positive JAK2 V617F was found in 13/75 patients (17%), who also had RCM above the mean normal predicted value, however, when the WHO RCM criteria were applied, only 7/13 (54%) could be considered as having “truly” increased RCM. In the patient group with negative JAK2 V617F test, 12/28 (43%) had RCM results as per WHO criteria. There was no statistical association between presence of JAK2 V617F and the RCM values. Conclusion In patients with negative JAK2 V617F but with high clinical suspicion for PV and all other causes of secondary and idiopathic erythrocytosis excluded, an increase in RCM would support the diagnosis of PV (about 10 % PV cases). In patients with JAK2 positive mutation and high haematocrit but RCM below the WHO cut-off level, an increased RCM would still count to confirm the diagnosis as the current standard level seems too stringent. References James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C et al. A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera. Nature 2005; 434(7037): 1144-8. Kralovics R, Passamonti F, Buser AS, Soon-Siong T, Tiedt R, Passweg JR, et al. A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders. Merck Manual of Diagnosis and Therapy. 16th Edition, 1992 McMullin MF, Bareford D, Campbell P, Green AR, Claire Harrison C, Hunt B, Oscier D, et al. Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis. British Journal of Haematology 2005; 130(2): 174-95. Scott LM, Tong W, Levine RL, et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007;356:459-468. Pardanani A, Lasho TL, Finke C, et al. Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia. 2007;21:1960-1963. Pancrazzi A, Guglielmelli P, Ponziani V, et al. A sensitive detection method for MPLW515L or MPLW515K mutation in chronic myeloproliferative disorders with locked nucleic acid-modified probes and real-time polymerase chain reaction. J Mol Diagn. 2008;10:435-441. Disclosures: No relevant conflicts of interest to declare.
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Rosay, Jean-Pierre, and Walter Rudin. "Holomorphic Maps from C n to C n." Transactions of the American Mathematical Society 310, no. 1 (November 1988): 47. http://dx.doi.org/10.2307/2001110.
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Halim, David, and Sugi Suhartono. "PENGARUH KEPEMILIKAN KELUARGA, KEPEMILIKAN INSTITUSIONAL, DAN KEPUTUSAN PENDANAAN TERHADAP KINERJA KEUANGAN DENGAN METODE PIOTROSKI F-SCORE." Jurnal Akuntansi 10, no. 1 (February 28, 2021): 8–20. http://dx.doi.org/10.46806/ja.v10i1.795.
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Financial performance is an achievement achieved by a company that can be seen through financial statements. Financial statements can be used as a control, a source of financial information and a representation of the company's performance. The results of financial statement analysis with various sizes of financial ratios can be used as material for evaluating company performance This study aims to determine the effect of family ownership, institutional ownership, and funding decisions on financial performance as measured by the Piotroski F-Score method. The number of samples in this study were 360 companies from the manufacturing sector with sub-sector basic and chemical industry, various industrial sectors and consumer goods listed on the Indonesia Stock Exchange during the period 2017 - 2019. The results of this study indicate that the data can be pooled for 3 years, all classical assumption tests are met and the results of the regression test show that family ownership > 0.05, institutional ownership and funding decisions < 0.05. So it can be concluded that there is not enough evidence of family ownership to have a positive effect on financial performance. Meanwhile, there is sufficient evidence that institutional ownership and funding decisions have a negative effect on financial performance.
Keywords: family ownership, institutional ownership, funding decisions, financial performance and Piotroski F-Score.
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Ghiraldelli Júnior, Paulo. "Business ethics." GV-executivo 5, no. 3 (October 3, 2006): 33. http://dx.doi.org/10.12660/gvexec.v5n3.2006.34296.
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A tradução de <em>business ethics</em> é, em geral, ética comercial. No entanto, é preferível manter o termo original, pois ele não significa a adoção ou a prescrição de um código de ética para empresas ou um código de ética profissional, embora possa até dar origem a isso. É antes um campo de pesquisa, de ação prática, publicações e instruções dirigidas para administradores e governo. O artigo analisa a história da <em>business ethics</em> mostrando ser ela um ponto de encontro entre filosofia e administração.
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Suprayekti, Suprayekti, and Fathia Fairuza Hanum. "PENERAPAN TEKNOLOGI PENDIDIKAN DI LEMBAGA PERSEKOLAHAN." Perspektif Ilmu Pendidikan 32, no. 2 (October 10, 2018): 165–79. http://dx.doi.org/10.21009/pip.322.9.
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Educational technology as applied science that changes the definition over time makes the study area and contribution of Educational Technology in the education system at Indonesia also changed. This study is to identify the implementation of Educational Technology areas that have been applied in school institutions at elementary school, so in the future undergraduate researchers can do further research. This study is a descriptive research and has a survey method. The purpose of this study is identifying the implementation of Educational Technology areas that have been applied in elementary school institutions consisting of the area of creating, using, managing and evaluation. This study conducted at SDN Tegal Alur 09 From August to October 2017. To collect the data, this study used a questionnaire sheet, an interview sheet, and documentation. The result of this study has two types data, first, in quantitave data all of Educational Technology areas have been applied in school institution, but only three areas, which get a very good score, meanwhile creating the area get a low score. Second, in descriptive analysis data, there are some indicators of creating the area that haven’t been applied yet, but on the other hand, some indicators in all of areas that have been applied still in the simple and restricted form. Based on the result, educational technology as the study and ethical practice to facilitate learning needs to be introduced closer to the school institutions, because school institution still doesn’t know the existence of educational technology and its areas.
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Wright, A. L., C. Gabel, M. Ballantyne, S. M. Jack, and O. Wahoush. "Using Two-Eyed Seeing in Research With Indigenous People: An Integrative Review." International Journal of Qualitative Methods 18 (January 1, 2019): 160940691986969. http://dx.doi.org/10.1177/1609406919869695.
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Background: The Two-Eyed Seeing approach has been advocated for use in research with Indigenous people as it creates a space for Western and Indigenous ways of knowing to come together using the best of both worldviews to aid understanding and solve problems. Foundational literature presents its use as a promising way to promote ethical exchanges between Indigenous and non-Indigenous people, but the practical application of its concepts to research remains vague. Method: This integrative review, using the Whittemore and Knafl approach, describes the state of the literature pertaining to the interpretation and application of Two-Eyed Seeing. Following a search of the literature, 37 articles were selected for inclusion, and primary studies ( n = 11) were critiqued for quality. Data were extracted, analyzed, and synthesized into themes. Results: Three themes were compiled from the literature including (a) defining characteristics of Two-Eyed Seeing, (b) suggested attributes of those engaging with Two-Eyed Seeing, and (c) the application of Two-Eyed Seeing in research. Conclusions: This review demonstrates inconsistencies in how to date researchers have interpreted and applied Two-Eyed Seeing in research with Indigenous people. The collection of key attributes of researchers and application procedures to research discussed in this review present a new standard for the application of Two-Eyed Seeing to research with Indigenous people. Researchers using Two-Eyed Seeing should thoroughly describe their application of its concepts to promote its maturation into a well-defined framework for research with Indigenous people.
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Rosay, Jean-Pierre, and Walter Rudin. "Holomorphic maps from ${\bf C}\sp n$ to ${\bf C}\sp n$." Transactions of the American Mathematical Society 310, no. 1 (January 1, 1988): 47. http://dx.doi.org/10.1090/s0002-9947-1988-0929658-4.
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Antonczak, Laurent, Marion Neukam, and Sophie Bollinger. "When industry meets academia." Pacific Journal of Technology Enhanced Learning 4, no. 1 (February 1, 2022): 14–16. http://dx.doi.org/10.24135/pjtel.v4i1.134.
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This presentation focuses on a transdisciplinary approach to innovative and collaborative learning practices driven by technology. It highlights two salient elements associated with industry practices and processes in relation to learning and educational contexts: empowerment of individuals and communities of practice through technology, and a broader consideration of industrial approaches to the concept of learning and teaching enhanced within a digital environment.
More precisely, this presentation will feature some of the key theoretical frameworks used in three different settings of learning and teaching in France with regards to the life-long learning approach thanks to Social and Emotional Learning (SEL) (WEF, 2016). It will also discuss the positive effect of the Internet and its affordances (Southerton & Taylor, 2020) on reducing the differences between theoretical and applied knowledge via professional-focused communities (Danvers, 2003). Thus, it will briefly explain that spatial and cognitive learning proximities (Lave & Wenger 1991; Fruchter, 2001) can be reduced by virtue of technology (Anders, 2016; Antonczak, 2019; Glazewski & Hmelo-Silver, 2019) and that ‘computer-supported collaborative learning’ methods can facilitate social and shared problem-solving (Sawyer, 2005; Levallet & Chan, 2018; Presicce et al., 2020) without the ‘restriction of time and place’ (Cheng et al., 2019, 489). Additionally, it will point out some aspects of problem-solving through ‘emancipatory learning and social action’ (Merriam, 2001, 9) through the use of ‘actual’ content and ‘actionable feedback’ (Woods & Hennessy, 2019) enhanced by digital tools and tactics.
Next, it will focus on three case studies by concisely presenting key specifics for each of the courses, including the various digital tools used and followed by some quick interim reflections.
Then it will summarise the challenges and the barriers encountered across the different practices such as virtual delivery, the size of the students' groups and some connectivity considerations. It will be followed by the principal advantages and opportunities, like the professionalisation dimension through interactive and authentic learning enhanced by affordances. And it will conclude with some managerial recommendations as experiential and practical methods (knowledge codification) thanks to industry-based teaching supported by digital technologies.
The presentation will close with the overall conclusion in relation to digital technology and some of the key 21st-century career skills. In general, the findings will be of interest to academics, practitioners and policymakers. The added value of this transdisciplinary investigation is that it improves research on collaborative innovation and collective knowledge by creating a bridge between the fields of Education and Business.
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Bressler, David C., and Phillip M. Fedorak. "Bacterial metabolism of fluorene, dibenzofuran, dibenzothiophene, and carbazole." Canadian Journal of Microbiology 46, no. 5 (May 1, 2000): 397–409. http://dx.doi.org/10.1139/w00-017.
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Fluorene and its three heteroatomic analogs, dibenzofuran, dibenzothiophene, and carbazole, are environmental contaminants in areas impacted by spills of creosote. In addition, dibenzofuran has been used as an insecticide, and it is formed from the photolysis of chlorinated biphenyl ethers. Many biodegradation studies of dibenzofuran have considered it as a model for chlorinated dibenzofurans, which are of greater environmental concern. This paper reviews the bacterial degradation of fluorene and its analogs. These compounds are susceptible to three different modes of initial oxidation: (i) the naphthalene-like attack, in which one of the aromatic rings is oxidized to a dihydrodiol; (ii) an angular dioxygenase attack, in which the carbon bonded to the methylene group in fluorene or to the heteroatoms in the analogs, and the adjacent carbon in the aromatic ring are both oxidized; and (iii) the five-membered ring attack, in which the methylene carbon atom in fluorene or the sulfur atom in dibenzothiophene is oxidized. The metabolites, enzymology, and genetics of these transformation are summarized. Literature data are presented, indicating that the electronegativity of the atom connecting the two aromatic rings influences the attack of the angular dioxygenase. In dibenzofuran and carbazole, the connecting atoms, O and N respectively, have high electronegativities, and these compounds serve as substrates for angular dioxygenases. In contrast, the connecting atoms in dibenzothiophene and fluorene, S and C respectively, have lower electronegativities, and these atoms must be oxidized before the angular dioxygenases attack these compounds.Key words: angular dioxygenase, carbazole, dibenzofuran, dibenzothiophene, fluorene.
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Huybrechts, C�cile, and Antonio Pasini. "On c n-2.c * geometries of order 2." Designs, Codes and Cryptography 9, no. 3 (November 1996): 317–30. http://dx.doi.org/10.1007/bf00129772.
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Putri, Widya Arga, and Darwanto. "Corporate Social Responsibility Disclosure Analysis with Social Performance Indicators in Sharia Banking in Indonesia." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 6 (December 7, 2022): 874–83. http://dx.doi.org/10.20473/vol9iss20226pp874-883.
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ABSTRAK Penelitian ini bertujuan untuk menganalisis tingkat pengungkapan Corporate Social Responsibility (CSR) perbankan syariah periode 2018-2020 dengan menggunakan indeks Social Performance Indicators (SPI). Indeks SPI memiliki kerangka kerja yang lebih luas dengan menambahkan aspek religiositas sebagai indikator penilaian. Penelitian ini bersifat deskriptif kualitatif-kuantitatif menggunakan metode analisis isi yang dikombinasikan dengan sistem pembobotan dan pemeringkatan menggunakan skala RDAP. Data pada penelitian ini menggunakan data sekunder yang diperoleh dari laporan tahunan setiap perbankan syariah. Sampel penelitian ini terdiri dari Bank Aceh Syariah, Bank NTB Syariah, Bank Mega Syariah, BTPN Syariah, BCA Syariah, BNI Syariah, dan Bank Syariah Mandiri. Penelitian ini menggunakan enam indikator yang terdiri dari Religiositas, Lingkungan, Masyarakat, Tata Kelola, Karyawan, dan Klien. Hasil penelitian ini menunjukkan bahwa Tata Kelola adalah dimensi yang paling banyak diungkapkan oleh perbankan syariah dengan skor 95,8%, sedangkan dimensi Klien memperoleh skor paling rendah yakni sebesar 53,4%. Pengungkapan CSR dengan indeks SPI perbankan syariah selama periode 2018-2020 secara keseluruhan memperoleh predikat proaktif dari skala RDAP dengan skor sebesar 85,6%. Penelitian ini membuktikan bahwa indikator yang digunakan indeks SPI telah mencakup hal-hal yang dibutuhkan perbankan syariah untuk menilai kinerja tanggung jawab sosialnya. Perbankan syariah diharapkan dapat memberikan kontribusi lebih pada dimensi klien di samping menjaga konsistensi tanggung jawab sosial pada dimensi lainnya. Kata Kunci: Corporate Social Responsibility, Social Performance Indicators, Pengungkapan, Pemeringkatan. ABSTRACT This study aimed to analyze the disclosure of Corporate Social Responsibility (CSR) of Islamic banking for the 2018-2020 period using the Social Performance Indicators (SPI) index. The SPI index has a broader framework by adding aspects of religiosity as an assessment indicator. This was a descriptive qualitative-quantitative research. It used the content analysis method combined with a weighting and ranking system which used the RDAP scale. The data in this study used secondary data obtained from the annual report of each Islamic banking. The sample of this research consisted of Bank Aceh Syariah, Bank NTB Syariah, Bank Mega Syariah, BTPN Syariah, BCA Syariah, BNI Syariah, and Bank Syariah Mandiri. This study used six indicators consisting of Religiosity, Environment, Society, Governance, Employees, and Clients. The results of this study indicate that Governance is the dimension most widely disclosed by Islamic banking with a score of 95.8%, while the Client dimension obtained the lowest score of 53.4%. CSR disclosure with the Islamic banking SPI index during the 2018-2020 period as a whole received a proactive predicate from the RDAP scale with a score of 85.6%. This research proves that the indicators used by the SPI index have covered the things that Islamic banks need to assess their social responsibility performance. Islamic banking is expected to contribute more to the client dimension while maintaining consistency in social responsibility in other dimensions. Keywords: Corporate Social Responsibility, Social Performance Indicators, Disclosure, Ranking. REFERENCES Amran, A., Fauzi, H., Purwanto, Y., Darus, F., Yusoff, H., Zain, M.M., Naim, D.M.A. & Nejati, M. (2017). Social responsibility disclosure in Islamic banks: A comparative study of Indonesia and Malaysia. Journal of Financial Reporting and Accounting, 15(1), 99-115. https://doi.org/10.1108/JFRA-01-2015-0016 Carroll, A. B. (1979). A three-dimensional conceptual model of corporate performance. Corporate Social Responsibility, 4(4), 37–45. https://doi.org/10.5465/amr.1979.4498296 Clarkson, M. E. (1995). A stakeholder framework for analyzing and evaluating corporate social performance. Academy of Management Review, 20(1), 92–117. https://doi.org/10.5465/amr.1995.9503271994 Desiana. (2018). Pelaporan corporate sosial responsibility (CSR) perbankan syariah dalam perspektif syariah enterprise theory. Jurnal Ekonomi Dan Hukum Islam, 2(2), 107–133. Fauzi, M., Akbarudin, W. H., Darmasetiawan, I. E., & Darussalam, A. (2020). Penerapan tanggung jawab sosial perbankan syariah milik negara dengan indeks Islamic social reporting. Jurnal Ilmiah Ekonomi Islam, 6(3), 488–500. http://dx.doi.org/10.29040/jiei.v6i3.1342 Fitria, S., & Hartanti, D. (2010). Islam dan tanggung jawab sosial: Studi perbandingan pengungkapan berdasarkan global reporting initiative indeks dan Islamic social reporting indeks. Simposium Nasional Akuntansi Purokerto. Gustani. (2014). Model pelaporan kinerja sosial perbankan syariah: Implementasi Islamic social reporting index di indonesia. Jakis: Jurnal Akuntansi dan Keuangan Islam, 2(1), 35–49. https://doi.org/10.35836/jakis.v2i1.51 Hadi, N. (2011). Corporate social responsibility. Graha Ilmu. Hamidi, L., & Worthington, A. C. (2020). How social is Islamic banking? Society and Business Review, 16(1), 51–70. https://doi.org/10.1108/SBR-03-2020-0036 Haniffa, R. (2002). Social reporting disclosure: An Islamic perspective. Indonesian Management & Accounting Research, 1(2), 128–146. Haniffa, R., & Hudaib, M. (2007). Exploring the ethical identity of Islamic banks via communication in annual reports. Journal of Business Ethics, 76(1), 97–116. https://doi.org/10.1007/s10551-006-9272-5 Hassan, A., & Harahap, S. S. (2010). Exploring corporate social responsibility disclosure: The case of Islamic banks. International Journal of Islamic and Middle Eastern Finance and Management, 3(3), 203–227. https://doi.org/10.1108/17538391011072417 Othman, R., Thani, A. M., & Ghani, E. K. (2015). Determinants of Islamic social reporting among top shariah-approved companies in Bursa Malaysia. Research Journal of International Studies, 12(May), 4–20. Potter, W. J., & Levine-Donnerstein, D. (1999). Rethinking validity and reliability in content analysis. Journal of Applied Communication Research, 27, 258–284. https://doi.org/10.1080/00909889909365539 Pratiwi, A., Nurulrahmatia, N., & Muniarty, P. (2020). Pengaruh corporate social responsibility (CSR) terhadap profitabilitas pada perusahaan. Owner: Riset dan Jurnal Akuntansi, 4(1), 95-103. https://doi.org/10.33395/owner.v4i1.201 Ramasamy, B., Yeung, M. C. H., & Au, A. K. M. (2010). Consumer support for corporate social responsibility (CSR): The role of religion and values. Journal of Business Ethics, 91, 61–72. Https://doi.org/10.1007/s10551-010-0568-0 Slamet, M. (2001). Enterprise Theory dalam konstruksi akuntansi syari’ah (Studi teoritis pada konsep akuntansi syari’ah). Skripsi tidak dipublikasikan. Universitas Brawijaya. Triyuwono, I. (2011). Mengangkat “sing liyan“ untuk formulasi nilai tambah syari’ah. Jurnal Akuntansi Multiparadigma, 2(2), 186–200. http://dx.doi.org/10.18202/jamal.2011.08.7116 Triyuwono, Iwan. (2006). Akuntansi syari’ ah: Perspektif, metodologi dan teori. Rajawali Press. Umam, K. (2009). Trend pembentukan bank umum syariah pasca UU no. 21 tahun 2008: konsep, regulasi, dan implementasi (1st ed.). BPFE Yogyakarta. Wartick, S. L., & Cochran, P. L. (1985). The evolution of the corporate social performance model. Academy of Management Review, 10(4), 758–769. https://doi.org/10.5465/amr.1985.4279099 Worthington, A. C. (2018). Islamic social banking: The way forward. Jurnal Ekonomi Malaysia, 52(1), 179-190. Yusuf, M. Y. (2017). Islamic corporate social responsibility (ICSR) pada lembaga keuangan syariah (LKS) teori dan praktik (Pertama). Kencana.
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Range, R. M., and M. I. Stessin. "Bounded Point Evaluation in C n." Transactions of the American Mathematical Society 347, no. 6 (June 1995): 2169. http://dx.doi.org/10.2307/2154930.
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Cima, Joseph A., and Emil J. Straube. "Boundary Uniqueness Theorems in C n." Transactions of the American Mathematical Society 294, no. 1 (March 1986): 333. http://dx.doi.org/10.2307/2000134.
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Platonov, V. P., and D. Ž. Đoković. "Subgroups of $GL(n^2, \bold C)$ containing $PSU(n)$." Transactions of the American Mathematical Society 348, no. 1 (1996): 141–52. http://dx.doi.org/10.1090/s0002-9947-96-01466-3.
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Park, Chun-Gil, and Themistocles M. Rassias. "The N-Isometric Isomorphisms in Linear N-Normed C*-Algebras." Acta Mathematica Sinica, English Series 22, no. 6 (September 22, 2006): 1863–90. http://dx.doi.org/10.1007/s10114-005-0878-9.
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Repovs, Dusan, Arkadij B. Skopenkov, and Evgenij V. Scepin. "$C^1$-homogeneous compacta in $\mathbb {R}^n$ are $C^1$-submanifolds of $\mathbb {R}^n$." Proceedings of the American Mathematical Society 124, no. 4 (1996): 1219–26. http://dx.doi.org/10.1090/s0002-9939-96-03157-7.
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Mashar, Riana, and Febru Pudji Astuti. "Correlation between Parenting Skills, Children’s Emotional and Intelligence Quotient with School Readiness." JPUD - Jurnal Pendidikan Usia Dini 16, no. 2 (November 30, 2022): 215–23. http://dx.doi.org/10.21009/jpud.162.02.
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School readiness is critical to academic achievement in first grade. However, often parents only focus on cognitive readiness without paying much attention to children's emotional factors and parental factors that affect school readiness. This study aims to identify the relationship between parenting skills, emotional quotient (EQ), intelligence (IQ), and children's school readiness. This study uses a correlation design that focuses on parental and internal factors. The research subjects were parents and students from 21 kindergartens in Magelang (n=165) who were selected through simple random sampling. Data collection was carried out through online questionnaires for parents, Raven Intelligence Scale, EQ Scale, and school readiness tests for children. The data obtained were analyzed through regression analysis techniques. The results of the study show that emotional intelligence has the strongest correlation with school readiness. Intelligence also correlates with children's school readiness. However, there is no significant correlation between parental skills and children's school readiness. Based on gender, there is no significant difference in school readiness between boys and girls. The findings of this study imply that school readiness needs to be improved by developing children's emotional intelligence as important as cognitive intelligence.
Keywords: parenting skills, children’s EQ and IQ, school readiness
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Larson, Rebecca, Michael Kann, Stefanie Bailey, Nicholas Haradhvala, Kai Stewart, Amanda Bouffard, Irene Scarfo, et al. "221 CRISPR screen identifies loss of IFNγR signaling and downstream adhesion as a resistance mechanism to CAR T-cell cytotoxicity in solid but not liquid tumors." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A234. http://dx.doi.org/10.1136/jitc-2021-sitc2021.221.
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BackgroundChimeric Antigen Receptor (CAR) therapy has had a transformative impact on the treatment of hematologic malignancies1–6 but success in solid tumors remains elusive. We hypothesized solid tumors have cell-intrinsic resistance mechanisms to CAR T-cell cytotoxicity.MethodsTo systematically identify resistance pathways, we conducted a genome-wide CRISPR knockout screen in glioblastoma cells, a disease where CAR T-cells have had limited efficacy.7 8 We utilized the glioblastoma cell line U87 and targeted endogenously expressed EGFR with CAR T-cells generated from 6 normal donors for the screen. We validated findings in vitro and in vivo across a variety of human tumors and CAR T-cell antigens.ResultsLoss of genes in the interferon gamma receptor (IFNγR) signaling pathway (IFNγR1, JAK1, JAK2) rendered U87 cells resistant to CAR T-cell killing in vitro. IFNγR1 knockout tumors also showed resistance to CAR T cell treatment in vivo in a second glioblastoma line U251 in an orthotopic model. This phenomenon was irrespective of CAR target as we also observed resistance with IL13Ralpha2 CAR T-cells. In addition, resistance to CAR T-cell cytotoxicity through loss of IFNγR1 applied more broadly to solid tumors as pancreatic cell lines targeted with either Mesothelin or EGFR CAR T-cells also showed resistance. However, loss of IFNγR signaling did not impact sensitivity of liquid tumor lines (leukemia, lymphoma or multiple myeloma) to CAR T-cells in vitro or in an orthotopic model of leukemia treated with CD19 CAR. We isolated the effects of decreased cytotoxicity of IFNγR1 knockout glioblastoma tumors to be cancer-cell intrinsic because CAR T-cells had no observable differences in proliferation, activation (CD69 and LFA-1), or degranulation (CD107a) when exposed to wildtype versus knockout tumors. Using transcriptional profiling, we determined that glioblastoma cells lacking IFNγR1 had lower upregulation of cell adhesion pathways compared to wildtype glioblastoma cells after exposure to CAR T-cells. We found that loss of IFNγR1 reduced CAR T-cell binding avidity to glioblastoma.ConclusionsThe critical role of IFNγR signaling for susceptibility of solid tumors to CAR T-cells is surprising given that CAR T-cells do not require traditional antigen-presentation pathways. Instead, in glioblastoma tumors, IFNγR signaling was required for sufficient adhesion of CAR T-cells to mediate productive cytotoxicity. Our work demonstrates that liquid and solid tumors differ in their interactions with CAR T-cells and suggests that enhancing T-cell/tumor interactions may yield improved responses in solid tumors.AcknowledgementsRCL was supported by T32 GM007306, T32 AI007529, and the Richard N. Cross Fund. ML was supported by T32 2T32CA071345-21A1. SRB was supported by T32CA009216-38. NJH was supported by the Landry Cancer Biology Fellowship. JJ is supported by a NIH F31 fellowship (1F31-MH117886). GG was partially funded by the Paul C. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center and NIH R01CA 252940. MVM and this work is supported by the Damon Runyon Cancer Research Foundation, Stand Up to Cancer, NIH R01CA 252940, R01CA238268, and R01CA249062.ReferencesMaude SL, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med 2018;378:439–448.Neelapu SS, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med 2017;377:2531–2544.Locke FL, et al. Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial. The Lancet Oncology 2019;20:31–42.Schuster SJ, et al. Chimeric antigen receptor T cells in refractory B-cell lymphomas. N Engl J Med 2017;377:2545–2554.Wang M, et al. KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma. N Engl J Med 2020;382:1331–1342.Cohen AD, et al. B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. J Clin Invest 2019;129:2210–2221.Bagley SJ, et al. CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges. Neuro-oncology 2018;20:1429–1438.Choi BD, et al. Engineering chimeric antigen receptor T cells to treat glioblastoma. J Target Ther Cancer 2017;6:22–25.Ethics ApprovalAll human samples were obtained with informed consent and following institutional guidelines under protocols approved by the Institutional Review Boards (IRBs) at the Massachusetts General Hospital (2016P001219). Animal work was performed according to protocols approved by the Institutional Animal Care and Use Committee (IACUC) (2015N000218 and 2020N000114).
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Yao, Olivia X. M. "The relations between N(a,b,c,d;n) and t(a,b,c,d;n) and (p,k)-parametrization of theta functions." Journal of Mathematical Analysis and Applications 453, no. 1 (September 2017): 125–43. http://dx.doi.org/10.1016/j.jmaa.2017.03.067.
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Xia, Ernest X. W., and Z. X. Zhong. "Proofs of some conjectures of Sun on the relations between N(a,b,c,d;n) and t(a,b,c,d;n)." Journal of Mathematical Analysis and Applications 463, no. 1 (July 2018): 1–18. http://dx.doi.org/10.1016/j.jmaa.2018.02.043.
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Bich Thuy, Nguyen Thi, and Maria Aparecida Soares Ruas. "On singular varieties associated to a polynomial mapping from $\mathbb{C}^n$ to $\mathbb{C}^{n-1}$." Asian Journal of Mathematics 22, no. 6 (2018): 1157–72. http://dx.doi.org/10.4310/ajm.2018.v22.n6.a9.
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Zhao, Liankuo. "Unitary Weighted Composition Operators on the Fock Space of $$\mathbb C ^n$$ C n." Complex Analysis and Operator Theory 8, no. 2 (June 11, 2013): 581–90. http://dx.doi.org/10.1007/s11785-013-0313-7.
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Hamada, Hidetaka, Mihai Iancu, and Gabriela Kohr. "Extremal Problems for Mappings with Generalized Parametric Representation in $${{\mathbb {C}}}^{n}$$ C n." Complex Analysis and Operator Theory 10, no. 5 (January 4, 2016): 1045–80. http://dx.doi.org/10.1007/s11785-015-0525-0.
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Khansa, Adelia De Tsamara, and Tika Widiastuti. "KAUSALITAS PERTUMBUHAN EKONOMI, ENERGI TERBARUKAN DAN DEGRADASI LINGKUNGAN PADA NEGARA ORGANISASI KERJASAMA ISLAM." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 1 (January 30, 2022): 118. http://dx.doi.org/10.20473/vol9iss20221pp118-130.
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ABSTRAKPenelitian ini bertujuan mengetahui hubungan kausalitas antara konsumsi energi konvensional, pertumbuhan ekonom, emisi karbon dioksida, dan konsumsi energi terbarukan di 39 negara Organisasi Kerjasama Islam (OKI) periode 1992-2018. Metode yang diterapkan ialah uji kausalitas Dumitrescu-Hurlin (2012) yang memperbolehkan adanya heterogenitas dan cross-sectional dependence. Temuan dari penelitian ini ialah terdapat interdependensi antara konsumsi energi konvensional dengan pertumbuhan ekonomi, sedangkan konsumsi energi terbarukan dipengaruhi oleh pertumbuhan ekonomi sebagaimana teori RKC U-shaped. Pertumbuhan ekonomi menyebabkan emisi karbon dioksida sebagaimana teori EKC-Kuznets. Tidak ditemukannnya hubungan kausalitas antara konsumsi energi konvensional dan terbarukan dengan emisi karbon dioksida. Penerapan kebijakan konservasi dapat diterapkan dengan memperhatikan pertumbuhan ekonomi. Penelitian terdahulu, menguji hubungan kausalitas tanpa memperhatikan cross-sectional dependence dan tidak memisahkan antara konsumsi energi konvensional dengan energi terbarukan. Kata Kunci: Energi terbarukan, Degradasi Lingkungan, Kausalitas. ABSTRACTThis research aims to find causality between conventional energy consumption, economic growth, carbon dioxide emissions, and renewable energy consumption in 39 countries of Organization of Islamic Cooperation (OIC) on 1992-2018. The method used Dumitrescu-Hurlin Causality Test (2012) that allows heterogeneity and cross-sectional dependence. The outcome affirms that there is interdependency between conventional energy consumption and economic growth, but renewable energy consumption affected economic growth that confirms RKC U-Shaped theory. The impact of economic growth affects environmental degradation, carbon dioxide emissions which accept EKC-Kuznets theory. 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There is some irony, and perhaps a bit of gallows humor, in opening a paper in this volume with the claim that “applied ethics” is a misnomer. Yet that claim is true in the following sense. What we need for most of the issues that have sparked the contemporary resurgence of moral and political theory is not the application of ethics as we know it, but the revamping of ethics to make it relevant to the issues we face. It is in our concern with major policy programs that ethics and political philosophy are most commonly rejoined to become a unified enquiry after a nearly complete separation through most of this century. Yet, ethical theories may be shaken to their foundations by our effort to apply them to policy problems. I do not propose to revamp ethics here, but only to show that much ethical theory cannot readily be applied to major policy problems.There are at least three important characteristics of major policy issues in general that may give traditional moral theories difficulties. First, such issues can generally be handled only by institutional intervention; they commonly cannot be resolved through uncoordinated individual action. Theories formulated at the individual level must therefore be recast to handle institutional actions and possibilities. Second, major policy issues typically have complicating strategic interactions between individuals at their bases. Third, they are inherently stochastic in the important sense that they affect large numbers with more or less determinable (or merely guessable) probabilities. C. H. Waddington calls such issues instances of “the problem of the ethics of stochastic processes.”
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