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Journal articles on the topic 'Apoptotic Photocytotoxicity'

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Author: Grafiati

Published: 6 September 2023

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1

Musib, Dulal, Mrityunjoy Pal, Md Kausar Raza, and Mithun Roy. "Photo-physical, theoretical and photo-cytotoxic evaluation of a new class of lanthanide(iii)–curcumin/diketone complexes for PDT application." Dalton Transactions 49, no. 31 (2020): 10786–98. http://dx.doi.org/10.1039/d0dt02082f.

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Improved ISC in La(iii) complex of curcumin, on activation with visible light, has resulted in high yield of ¹O₂ in HeLa/MCF-7 cells, leading to the oxidative stress which was responsible for remarkable caspase 3/7-dependent apoptotic photocytotoxicity.

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2

Panzarini, Elisa, Valentina Inguscio, and Luciana Dini. "Overview of Cell Death Mechanisms Induced by Rose Bengal Acetate-Photodynamic Therapy." International Journal of Photoenergy 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/713726.

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Photodynamic Therapy (PDT) is a non-invasive treatment for different pathologies, cancer included, using three key components: non-toxic light-activated drug (Photosensitizer, PS), visible light, and oxygen. Their interaction triggers photochemical reactions leading to Reactive Oxygen Species (ROS) generation, that mediate cytotoxicity and cell death. In the present paper, the most important findings about the synthetic dye Rose Bengal Acetate (RBAc), an emerging photosensitizer for its efficient induction of cell death, will be reported with the aim to integrate RBAc phototoxicity to novel therapeutic PDT strategies against tumour cells. After its perinuclear intracellular localization, RBAc causes multiple subcellular organelles damage, that is, mitochondria, Endoplasmic Reticulum (ER), lysosomes, and Golgi complex. Indeed, RBAc exerts long-term phototoxicity through activation of both caspase-independent and- dependent apoptotic pathways and autophagic cell death. In particular, this latter cell death type may promote cell demise when apoptotic machinery is defective. The deep knowledge of RBAc photocytotoxicity will allow to better understand its potential photomedicine application in cancer.

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3

Wu, Ricky W. K., Ellie S. M. Chu, Zheng Huang, Malini C. Olivo, David C. W. Ip, and Christine M. N. Yow. "An in vitro investigation of photodynamic efficacy of FosPegⓇ on human colon cancer cells." Journal of Innovative Optical Health Sciences 08, no. 05 (August 21, 2015): 1550027. http://dx.doi.org/10.1142/s1793545815500273.

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Photodynamic therapy (PDT) is a novel therapeutic approach for combating various cancers. PDT involves the administration of a photosensitizer which generates singlet oxygen after light activation. FosPegⓇ is the liposomal formulation of mTHPC. In this in vitro study, the photodynamic efficacy of FosPegⓇ on a human colon cancer cell line (HT29) was investigated via studying the cellular uptake of FosPegⓇ, FosPegⓇ PDT mediated photocytotoxicity and the cell death mechanism were triggered. FosPegⓇ PDT demonstrated its antitumor effect in a drug and light dose-dependent manner in HT-29 cells. Lethal dose (LD50) was achieved with 0.4 μg/mL of drug and 3 J/cm-2 of light dose. FosPegⓇ PDT triggered apoptotic cell death via activating caspase cascade and regulating cell cycle progression. In conclusion, FosPegⓇ-PDT is an effective measure to combat human colon cancer cells.

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4

Banerjee, Samya, Ila Pant, Imran Khan, Puja Prasad, Akhtar Hussain, Paturu Kondaiah, and Akhil R. Chakravarty. "Remarkable enhancement in photocytotoxicity and hydrolytic stability of curcumin on binding to an oxovanadium(iv) moiety." Dalton Transactions 44, no. 9 (2015): 4108–22. http://dx.doi.org/10.1039/c4dt02165g.

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5

Banerjee, Samya, Akanksha Dixit, Anjali A. Karande, and Akhil R. Chakravarty. "Endoplasmic reticulum targeting tumour selective photocytotoxic oxovanadium(iv) complexes having vitamin-B6 and acridinyl moieties." Dalton Transactions 45, no. 2 (2016): 783–96. http://dx.doi.org/10.1039/c5dt03412d.

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Vitamin-B6 Schiff base complexes of oxovanadium(iv) having (acridinyl)dipyridophenazine show tumor selective visible light-induced photocytotoxicity by endoplasmic reticulum targeting¹O₂-mediated apoptosis.

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6

Mukherjee, Nandini, Santosh Podder, Koushambi Mitra, Shamik Majumdar, Dipankar Nandi, and Akhil R. Chakravarty. "Targeted photodynamic therapy in visible light using BODIPY-appended copper(ii) complexes of a vitamin B6Schiff base." Dalton Transactions 47, no. 3 (2018): 823–35. http://dx.doi.org/10.1039/c7dt03976j.

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7

Lin, Hong-Jhih, Jinn-Hsuan Ho, Li-Chen Tsai, Fang-Yu Yang, Ling-Ling Yang, Cheng-Deng Kuo, Lih-Geeng Chen, Yi-Wen Liu, and Jin-Yi Wu. "Synthesis and In Vitro Photocytotoxicity of 9-/13-Lipophilic Substituted Berberine Derivatives as Potential Anticancer Agents." Molecules 25, no. 3 (February 5, 2020): 677. http://dx.doi.org/10.3390/molecules25030677.

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The objective of this study was to synthesize the 9-/13-position substituted berberine derivatives and evaluate their cytotoxic and photocytotoxic effects against three human cancer cell lines. Among all the synthesized compounds, 9-O-dodecyl- (5e), 13-dodecyl- (6e), and 13-O-dodecyl-berberine (7e) exhibited stronger growth inhibition against three human cancer cell lines, (HepG2, HT-29 and BFTC905), in comparison with structurally related berberine (1). These three compounds also showed the photocytotoxicity in human cancer cells in a concentration-dependent and light dose-dependent manner. Through flow cytometry analysis, we found out a lipophilic group at the 9-/13-position of berberine may have facilitated its penetration into test cells and hence enhanced its photocytotoxicity on the human liver cancer cell HepG2. Further, in cell cycle analysis, 5e, 6e, and 7e induced HepG2 cells to arrest at the S phase and caused apoptosis upon irradiation. In addition, photodynamic treatment of berberine derivatives 5e, 6e, and 7e again showed a significant photocytotoxic effects on HepG2 cells, induced remarkable cell apoptosis, greatly increased intracellular ROS level, and the loss of mitochondrial membrane potential. These results over and again confirmed that berberine derivatives 5e, 6e, and 7e greatly enhanced photocytotoxicity. Taken together, the test data led us to conclude that berberine derivatives with a dodecyl group at the 9-/13-position could be great candidates for the anti-liver cancer medicines developments.

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8

Wu Klingler, Wenyu, Nadine Giger, Lukas Schneider, Vipin Babu, Christiane König, Patrick Spielmann, Roland H. Wenger, Stefano Ferrari, and Bernhard Spingler. "Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy." International Journal of Molecular Sciences 23, no. 17 (August 23, 2022): 9525. http://dx.doi.org/10.3390/ijms23179525.

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Phthalocyanines (Pcs) are promising candidates for photodynamic therapy (PDT) due to their absorption in the phototherapeutic window. However, the highly aromatic Pc core leads to undesired aggregation and decreased reactive oxygen species (ROS) production. Therefore, short PEG chain functionalized A3B type asymmetric Pc photosensitizers (PSs) were designed in order to decrease aggregation and increase the aqueous solubility. Here we report the synthesis, characterization, optical properties, cellular localization, and cytotoxicity of three novel Pc-based agents (LC31, MLC31, and DMLC31Pt). The stepwise functionalization of the peripheral moieties has a strong effect on the distribution coefficient (logP), cellular uptake, and localization, as well as photocytotoxicity. Additional experiments have revealed that the presence of the malonic ester moiety in the reported agent series is indispensable in order to induce photocytotoxicity. The best-performing agent, MLC31, showed mitochondrial targeting and an impressive phototoxic index (p.i.) of 748 in the cisplatin-resistant A2780/CP70 cell line, after a low-dose irradiation of 6.95 J/cm2. This is the result of a high photocytotoxicity (IC50 = 157 nM) upon irradiation with near-infrared (NIR) light, and virtually no toxicity in the dark (IC50 = 117 μM). Photocytotoxicity was subsequently determined under hypoxic conditions. Additionally, a preliminarily pathway investigation of the mitochondrial membrane potential (MMP) disruption and induction of apoptosis by MLC31 was carried out. Our results underline how agent design involving both hydrophilic and lipophilic peripheral groups may serve as an effective way to improve the PDT efficiency of highly aromatic PSs for NIR light-mediated cancer therapy.

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9

Banaspati, Atrayee, Vanitha Ramu, Md Kausar Raza, and Tridib K. Goswami. "Copper(ii) curcumin complexes for endoplasmic reticulum targeted photocytotoxicity." RSC Advances 12, no. 47 (2022): 30722–33. http://dx.doi.org/10.1039/d2ra04813b.

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10

Yow, Christine M. N., N. K. Mak, Albert W. N. Leung, and Zheng Huang. "Induction of early apoptosis in human nasopharyngeal carcinoma cells by mTHPC-mediated photocytotoxicity." Photodiagnosis and Photodynamic Therapy 6, no. 2 (June 2009): 122–27. http://dx.doi.org/10.1016/j.pdpdt.2009.06.003.

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11

Leung, W. N., X. Sun, N. K. Mak, and C. M. N. Yow. "Photodynamic Effects of mTHPC on Human Colon Adenocarcinoma Cells: Photocytotoxicity, Subcellular Localization and Apoptosis¶." Photochemistry and Photobiology 75, no. 4 (May 1, 2007): 406–11. http://dx.doi.org/10.1562/0031-8655(2002)0750406peomoh2.0.co2.

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12

Leung, W. N., X. Sun, N. K. Mak, and C. M. N. Yow. "Photodynamic Effects of mTHPC on Human Colon Adenocarcinoma Cells: Photocytotoxicity, Subcellular Localization and Apoptosis¶." Photochemistry and Photobiology 75, no. 4 (2002): 406. http://dx.doi.org/10.1562/0031-8655(2002)075<0406:peomoh>2.0.co;2.

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13

Zhu, Li, Hui Liu, Yang Dou, Qun Luo, Liangzhen Gu, Xingkai Liu, Qianxiong Zhou, Juanjuan Han, and Fuyi Wang. "A Photoactivated Ru (II) Polypyridine Complex Induced Oncotic Necrosis of A549 Cells by Activating Oxidative Phosphorylation and Inhibiting DNA Synthesis as Revealed by Quantitative Proteomics." International Journal of Molecular Sciences 24, no. 9 (April 24, 2023): 7756. http://dx.doi.org/10.3390/ijms24097756.

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The ruthenium polypyridine complex [Ru(dppa)2(pytp)] (PF6)2 (termed as ZQX-1), where dppa = 4,7-diphenyl-1,10-phenanthroline and pytp = 4′-pyrene-2,2′:6′,2′′-terpyridine, has been shown a high and selective cytotoxicity to hypoxic and cisplatin-resistant cancer cells either under irradiation with blue light or upon two-photon excitation. The IC50 values of ZQX-1 towards A549 cancer cells and HEK293 health cells are 0.16 ± 0.09 µM and >100 µM under irradiation at 420 nm, respectively. However, the mechanism of action of ZQX-1 remains unclear. In this work, using the quantitative proteomics method we identified 84 differentially expressed proteins (DEPs) with |fold-change| ≥ 1.2 in A549 cancer cells exposed to ZQX-1 under irradiation at 420 nm. Bioinformatics analysis of the DEPs revealed that photoactivated ZQX-1 generated reactive oxygen species (ROS) to activate oxidative phosphorylation signaling to overproduce ATP; it also released ROS and pyrene derivative to damage DNA and arrest A549 cells at S-phase, which synergistically led to oncotic necrosis and apoptosis of A549 cells to deplete excess ATP, evidenced by the elevated level of PRAP1 and cleaved capase-3. Moreover, the DNA damage inhibited the expression of DNA repair-related proteins, such as RBX1 and GPS1, enhancing photocytotoxicity of ZQX-1, which was reflected in the inhibition of integrin signaling and disruption of ribosome assembly. Importantly, the photoactivated ZQX-1 was shown to activate hypoxia-inducible factor 1A (HIF1A) survival signaling, implying that combining use of ZQX-1 with HIF1A signaling inhibitors may further promote the photocytotoxicity of the prodrug.

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14

Manav, Neha, Mohsin Y. Lone, Md Kausar Raza, Jaydeepsinh Chavda, Shigeki Mori, and Iti Gupta. "Luminescent iridium(iii) dipyrrinato complexes: synthesis, X-ray structures, and DFT and photocytotoxicity studies of glycosylated derivatives." Dalton Transactions 51, no. 10 (2022): 3849–63. http://dx.doi.org/10.1039/d1dt04218a.

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Synthesis and studies of luminescent Ir(iii) dipyrrinato complexes are reported. The ER targeting glycosylated Ir(iii) dipyrrinato complexes are able to cause ER stress after singlet oxygen generation leading to cell apoptosis.

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15

Kumar, Priyaranjan, Prerana Singh, Sanjoy Saren, Sandip Pakira, Sri Sivakumar, and Ashis K. Patra. "Kinetically labile ruthenium(ii) complexes of terpyridines and saccharin: effect of substituents on photoactivity, solvation kinetics, and photocytotoxicity." Dalton Transactions 50, no. 23 (2021): 8196–217. http://dx.doi.org/10.1039/d1dt00246e.

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16

Hammerle, Fabian, Lisa-Maria Steger, Xuequan Zhou, Sylvestre Bonnet, Lesley Huymann, Ursula Peintner, and Bianka Siewert. "Optimized isolation of 7,7′-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers." Photochemical & Photobiological Sciences 21, no. 2 (December 31, 2021): 221–34. http://dx.doi.org/10.1007/s43630-021-00159-y.

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AbstractMushrooms such as the dermocyboid Cortinarius rubrophyllus are characterized by strikingly colorful fruiting bodies. The molecular dyes responsible for such colors recently experienced a comeback as photoactive compounds with remarkable photophysical and photobiological properties. One of them—7,7′-biphyscion—is a dimeric anthraquinone that showed promising anticancer effects in the low nanomolar range under blue-light irradiation. Compared to acidic anthraquinones, 7,7′-biphyscion was more efficiently taken up by cells and induced apoptosis after photoactivation. However, seasonal collection of mushrooms producing this compound, low extraction yields, and tricky fungal identification hamper further developments to the clinics. To bypass these limitations, we demonstrate here an alternative approach utilizing a precursor of 7,7′-biphyscion, i.e., the pre-anthraquinone flavomannin-6,6′-dimethyl ether, which is abundant in many species of the subgenus Dermocybe. Controlled oxidation of the crude extract significantly increased the yield of 7,7′-biphyscion by 100%, which eased the isolation process. We also present the mycochemical and photobiological characterization of the yet chemically undescribed species, i.e. C. rubrophyllus. In total, eight pigments (1–8) were isolated, including two new glycosylated anthraquinones (1 and 2). Light-dependent generation of singlet oxygen was detected for the first time for emodin-1-O-β-d-glucopyranoside (3) [photophysical measurement: Φ∆ = 0.11 (CD3OD)]. Furthermore, emodin (7) was characterized as promising compound in the photocytotoxicity assay with EC50-values in the low micromolar range under irradiation against cells of the cancer cell lines AGS, A549, and T24. Graphical abstract

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17

Paunovic, Verica, Biljana Ristic, Zoran Markovic, Biljana Todorovic-Markovic, Milica Kosic, Jovana Prekodravac, Tamara Kravic-Stevovic, et al. "c-Jun N-terminal kinase-dependent apoptotic photocytotoxicity of solvent exchange-prepared curcumin nanoparticles." Biomedical Microdevices 18, no. 2 (April 2016). http://dx.doi.org/10.1007/s10544-016-0062-2.

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18

Barreca, Marilia, Angela Maria Ingarra, Maria Valeria Raimondi, Virginia Spanò, Antonio Palumbo Piccionello, Michele De Franco, Luca Menilli, et al. "New tricyclic systems as photosensitizers towards triple negative breast cancer cells." Archives of Pharmacal Research, November 18, 2022. http://dx.doi.org/10.1007/s12272-022-01414-1.

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AbstractNineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm2). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive oxygen species while their photodegradation products were not responsible for their activity. The most active compounds exhibited photocytotoxicity with IC50 values at low micromolar level inducing a decrease in the intracellular content of thiol, thus triggering cancer cell death through apoptosis. All the pyridone derivatives revealed to be pure photosensitizers with preferential photocytotoxic activity towards cancerous over healthy cells. Altogether, the results obtained confirm pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones as promising photosensitisers against triple-negative breast cancer.

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19

Hammerle, Fabian, Isabella Bingger, Andrea Pannwitz, Alexander Magnutzki, Ronald Gstir, Adriano Rutz, Jean-Luc Wolfender, Ursula Peintner, and Bianka Siewert. "Targeted isolation of photoactive pigments from mushrooms yielded a highly potent new photosensitizer: 7,7′-biphyscion." Scientific Reports 12, no. 1 (January 21, 2022). http://dx.doi.org/10.1038/s41598-022-04975-9.

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AbstractPigments of fungi are a fertile ground of inspiration: they spread across various chemical backbones, absorption ranges, and bioactivities. However, basidiomycetes with strikingly colored fruiting bodies have never been explored as agents for photodynamic therapy (PDT), even though known photoactive compound classes (e.g., anthraquinones or alkaloids) are used as chemotaxonomic markers. In this study, we tested the hypothesis that the dyes of skin-heads (dermocyboid Cortinarii) can produce singlet oxygen under irradiation and thus are natural photosensitizers. Three photosensitizers based on anthraquinone structures were isolated and photopharmaceutical tests were conducted. For one of the three, i.e., (–)-7,7′-biphyscion (1), a promising photoyield and photocytotoxicity of EC50 = 0.064 µM against cancer cells (A549) was found under blue light irradiation (λexc = 468 nm, 9.3 J/cm2). The results of molecular biological methods, e.g., a viability assay and a cell cycle analysis, demonstrated the harmlessness of 1 in the dark and highlighted the apoptosis-inducing PDT potential under blue light irradiation. These results demonstrate for the first time that pigments of dermocyboid Cortinarii possess a so far undescribed activity, i.e., photoactivity, with significant potential for the field of PDT. The dimeric anthraquinone (–)-7,7′-biphyscion (1) was identified as a promising natural photosensitizer.

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