Relevant bibliographies by topics / APC model

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Academic literature on the topic 'APC model'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "APC model"

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Booth, JL, ES Duggan, VI Patel, et al. "ID: 106: ALVEOLAR ESCAPE BY BACILLUS ANTHRACIS SPORES DOES NOT REQUIRE A CARRIER CELL AND IS NOT ALTERED BY LETHAL TOXIN." Journal of Investigative Medicine 64, no. 4 (2016): 960.2–961. http://dx.doi.org/10.1136/jim-2016-000120.101.

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RationaleThe lung is the entry site for Bacillus anthracis in inhalation anthrax, the most deadly form of the disease. B. anthracis spores must escape from the alveolus, pass to the regional lymph nodes, germinate and enter the circulatory system as vegetative bacteria to cause systemic disease. Of the resident lung cells, three have been reported to take up B. anthracis spores: the antigen presenting cells (APC) alveolar macrophages and dendritic cells, and alveolar epithelial cells (AEC). Also, B. anthracis produces the exotoxins lethal factor and protective antigen (PA) which combine to form lethal toxin (LT), a metalloproteinase important in pathogenicity. The roles of carrier cells and the effects of B. anthracis toxins in escape of spores from the alveolus are unclear, especially in humans.MethodsWe employed a human lung organ culture model and a human A549 alveolar epithelial cell culture model, along with fluorescent confocal imaging to quantitate spore partitioning between APC and AEC, and the effects of B. anthracis LT and PA on this process. Cell types were distinguished by positive staining for HLA-DR (APC) and cytokeratin (AEC).ResultsWe found that spores progressed through the lung slice over time, and that spore movement was not dependent on cell internalization. Both free and cell-associated spores moved through slices between 2 and 48 hrs of incubation. However, partitioning of spores between AEC, APC, and the extracellular space did not significantly change over this time. After 2 hrs, 4.7% of spores were in APC; 13.8% in AEC; and 81.5% were not cell-associated. By 48 hrs, 2.9% were in APC; 12.7% were in AEC; and 84.4% were not cell-associated. Spores also internalized in a non-uniform manner, with more variable spore internalization into AEC than into APC. At all incubation times, the majority of cell-associated spores were in AEC, not in APC. PA and LT did not affect transit of the spores through the lung tissue or the distribution of spores into AEC and APC. In A549 cells, spore internalization increased significantly after 24 hrs incubation. However, there was no statistically consistent effects of PA or LT on spore internalization in A549 cells.ConclusionsOverall, our results support a “Jailbreak”-like model of spore escape from the alveolus that involves transient passage of spores, although this occurs through intact AEC. However, subsequent transport of spores by APC from the lung to the lymph nodes may occur.
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Kulkarni, Kiran, Ziguo Zhang, Leifu Chang, Jing Yang, Paula C. A. da Fonseca, and David Barford. "Building a pseudo-atomic model of the anaphase-promoting complex." Acta Crystallographica Section D Biological Crystallography 69, no. 11 (2013): 2236–43. http://dx.doi.org/10.1107/s0907444913018593.

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The anaphase-promoting complex (APC/C) is a large E3 ubiquitin ligase that regulates progression through specific stages of the cell cycle by coordinating the ubiquitin-dependent degradation of cell-cycle regulatory proteins. Depending on the species, the active form of the APC/C consists of 14–15 different proteins that assemble into a 20-subunit complex with a mass of approximately 1.3 MDa. A hybrid approach of single-particle electron microscopy and protein crystallography of individual APC/C subunits has been applied to generate pseudo-atomic models of various functional states of the complex. Three approaches for assigning regions of the EM-derived APC/C density map to specific APC/C subunits are described. This information was used to dock atomic models of APC/C subunits, determined either by protein crystallography or homology modelling, to specific regions of the APC/C EM map, allowing the generation of a pseudo-atomic model corresponding to 80% of the entire complex.
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Zeng, Biqing, Feng Zeng, Heng Yang, Wu Zhou, and Ruyang Xu. "Multi-task learning model for aspect term extraction and aspect polarity classification based on dual-labels." Journal of Intelligent & Fuzzy Systems 39, no. 3 (2020): 2763–74. http://dx.doi.org/10.3233/jifs-191047.

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Aspect-based sentiment analysis (ABSA) is a hot and significant task of natural language processing, which is composed of two subtasks, the aspect term extraction (ATE) and aspect polarity classification (APC). Previous researches generally studied two subtasks independently and designed neural network models for ATE and APC respectively. However, it integrates various manual features into the model, which will consume plenty of computing resources and labor. Moreover, the quality of the ATE results will affect the performance of APC. This paper proposes a multi-task learning model based on dual auxiliary labels for ATE and APC. In this paper, general IOB labels, and sentimental IOB labels are equipped to efficiently solve both ATE and APC tasks without manual features adopted. Experiments are conducted on two general ABSA benchmark datasets of SemEval-2014. The experimental results reveal that the proposed model is of great performance and efficient for both ATE and APC tasks compared to the main baseline models.
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Swietlicki, Elzbieta A., Shashi Bala, Jianyun Lu, et al. "Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 8 (2013): G564—G572. http://dx.doi.org/10.1152/ajpgi.00486.2012.

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Interactions between the epithelium and surrounding mesenchyme/stroma play an important role in normal gut morphogenesis, the epithelial response to injury, and epithelial carcinogenesis. The tumor microenvironment, composed of stromal cells including myofibroblasts and immune cells, regulates tumor growth and the cancer stem cell niche. Deletion of epimorphin (Epim), a syntaxin family member expressed in myofibroblasts and macrophages, results in partial protection from colitis and from inflammation-induced colon cancer in mice. We sought to determine whether epimorphin deletion protects from polyposis in the Apc min/+ mouse model of intestinal carcinogenesis. Epim− /− mice were crossed to Apc min/+ mice; Apc min/+ and Apc min/+ /Epim− /− mice were killed at 3 mo of age. Polyp numbers and sizes were quantified in small intestine and colon, and gene expression analyses for pathways relevant to epithelial carcinogenesis were performed. Primary myofibroblast cultures were isolated, and expression and secretion of selected growth factors from Apc min/+ and Apc min/+ /Epim− /− myofibroblasts were examined by ELISA. Small bowel polyposis was significantly inhibited in Apc min/+ /Epim− /− compared with Apc min/+ mice. Apc min/+ /Epim− /− compared with Apc min/+ polyps and adjacent uninvolved intestinal mucosa had increased transforming growth factor-β (TGF-β) expression and signaling with increased P-Smad2/3 expression. Myofibroblasts isolated from Apc min/+ /Epim− /− vs. Apc min/+ mice had markedly decreased hepatocyte growth factor (HGF) expression and secretion. We concluded that Epim deletion inhibits polyposis in Apc min/+ mice, associated with increased mucosal TGF-β signaling and decreased myofibroblast HGF expression and secretion. Our data suggest that Epim deletion reduces tumorigenicity of the stromal microenvironment.
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Luo, Liying, and James S. Hodges. "Constraints in Random Effects Age-Period-Cohort Models." Sociological Methodology 50, no. 1 (2020): 276–317. http://dx.doi.org/10.1177/0081175020903348.

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Random effects (RE) models have been widely used to study the contextual effects of structures such as neighborhoods or schools. The RE approach has recently been applied to age-period-cohort (APC) models that are unidentified because the predictors are exactly linearly dependent. However, research has not fully explained how the RE specification identifies these otherwise unidentified APC models. We address this challenge by first making explicit that RE-APC models have greater—not less—rank deficiency than the traditional fixed-effects model, followed by two empirical examples. We then provide intuition and a mathematical proof to explain that for APC models with one RE, treating one effect as an RE is equivalent to constraining the estimates of that effect’s linear component and the random intercept to be zero. For APC models with two REs, the effective constraints implied by the model depend on the true (i.e., in the data-generating mechanism) nonlinear components of the effects that are modeled as REs, so that the estimated linear components of the REs are determined by the true nonlinear components of those effects. In conclusion, RE-APC models impose arbitrary although highly obscure constraints and thus do not differ qualitatively from other constrained APC estimators.
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Arnljots, Björn, David Bergqvist, and Björn Dahlbäck. "Inhibition of Microarterial Thrombosis by Activated Protein C in a Rabbit Model." Thrombosis and Haemostasis 72, no. 03 (1994): 415–20. http://dx.doi.org/10.1055/s-0038-1648881.

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SummaryProtein C is the key component in a natural anticoagulant pathway. After its activation by the thrombin-thrombomodulin complex, it degrades the activated forms of coagulation cofactors VIII and V, which leads to downregulation of the coagulation process. Due to its specific anticoagulant activity, activated protein C (APC) is potentially interesting as an antithrombotic agent. The effect of bovine activated protein C on thrombus formation and haemostasis was investigated in a rabbit model of microarterial thrombosis. Segments of both central ear arteries were prepared and blood-flow interrupted with double vascular clamps.Longitudinal arteriotomies (7 mm) and deep vessel wall trauma (5 mm) were performed, whereafter the arteriotomies were closed with running sutures. Five minutes prior to opening of the clamps (reperfusion), boluses of APC (0.8 mg/kg body weight) or vehicle alone were administered to two groups, each of 10 rabbits, in a blind random fashion. Vessel patency-rates were drastically improved by the administration of APC compared to vehicle. Correspondingly, thrombus weights were significantly lower in the APC group than in the control group. The activated partial thromboplastin time was prolonged to approximately twice the baseline throughout the 2 h observation interval in the APC group. Levels of circulating platelets were unaffected by the APC infusion, but the arteriotomy bleeding times were significantly longer in the APC group. In summary, activated protein C exerted powerful and long-acting antithrombotic effects in a microarterial model of thrombosis in rabbits.
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Zhang, Yongke, and Emma Lees. "Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation." Molecular and Cellular Biology 21, no. 15 (2001): 5190–99. http://dx.doi.org/10.1128/mcb.21.15.5190-5199.2001.

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ABSTRACT Activation of the anaphase-promoting complex (APC) is required for anaphase initiation and for exit from mitosis in mammalian cells. Cdc20, which specifically recognizes APC substrates involved in the metaphase-to-anaphase transition, plays a pivotal role in APC activation through direct interaction with the APC. The activation of the APC by Cdc20 is prevented by the interaction of Cdc20 with Mad2 when the spindle checkpoint is activated. Using deletion mutagenesis and peptide mapping, we have identified the sequences in Cdc20 that target it to Mad2 and the APC, respectively. These sequences are distinct but overlapping, providing a possible structural explanation for the internal modulation of the APC-Cdc20 complex by Mad2. In the course of these studies, a truncation mutant of Cdc20 (1–153) that constitutively binds Mad2 but fails to bind the APC was identified. Overexpression of this mutant induces the formation of multinucleated cells and increases their susceptibility to undergoing apoptosis when treated with microtubule-inhibiting drugs. Our experiments demonstrate that disruption of the Mad2-Cdc20 interaction perturbs the mitotic checkpoint, leading to premature activation of the APC, sensitizing the cells to the cytotoxic effects of microtubule-inhibiting drugs.
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Hoogendoorn, H., ME Nesheim, and AR Giles. "A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model." Blood 75, no. 11 (1990): 2164–71. http://dx.doi.org/10.1182/blood.v75.11.2164.2164.

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Abstract A model of Protein C (PC) activation in vivo was used to investigate the complexing of activated PC (APC) with its plasma inhibitors, PC inhibitor (PCI) and alpha 1-antitrypsin (alpha 1AT). Chimpanzees were infused with a bolus of activated factor X (F.Xa) together with vesicles of phosphatidylcholine and phosphatidylserine (PCPS). Pre- and post-infusion plasma samples were analyzed using enzyme linked immunosorbent based assays (ELISA) for PC and APC complexes, and immunoblotting of PC from nondenaturing polyacrylamide gel electrophoresis. Within 2 minutes of infusion, a 60% decrease in nonactivated PC zymogen (PCz) levels was observed. This coincided with a precipitous drop in plasma activities of cofactors VIIIa and Va. In contrast, total PC antigen (PCt) levels decreased by only 1%, indicating APC generation. Complexes of APC with both PCI and alpha 1AT were observed on immunoblots, and further identified and quantified using a sandwich ELISA employing antibodies to both PC and these inhibitors. The distribution of APC between these two inhibitors varied with the dose of F.Xa/PCPS infused. At a dose of F.Xa/PCPS of 24.05 pmol and 37.70 nmol/kg, respectively, an initial spike of APC generation, associated with decreases in the levels of factors VIIIa and Va, was noted but dissipated over the next 30 minutes. During this period, APC/inhibitor complexes appeared with the levels of APC-PCI and APC-alpha 1AT reaching 8.5 nmol/L and 2.2 nmol/L by 30 minutes, respectively. In contrast, at a higher dose of F.Xa/PCPS of 36.60 pmol and 56.30 nmol/Kg respectively, complexes of APC-alpha 1AT appeared rapidly and reached a level of 6 nmol/L by 30 minutes postinfusion, whereas APC-PCI complexes were only present at a concentration of 3.4 nmol/L by this time. Additional experiments with lower doses of F.Xa/PCPS suggest that PCI is the preferred inhibitor of APC, but as the availability of this inhibitor becomes limiting, alpha 1AT plays an increasingly crucial role as a secondary inhibitor of endogenously generated APC. Moreover, evidence is presented suggesting the existence of additional inhibitor(s) of APC that may have a role similar to alpha 1AT.
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Hoogendoorn, H., ME Nesheim, and AR Giles. "A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model." Blood 75, no. 11 (1990): 2164–71. http://dx.doi.org/10.1182/blood.v75.11.2164.bloodjournal75112164.

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A model of Protein C (PC) activation in vivo was used to investigate the complexing of activated PC (APC) with its plasma inhibitors, PC inhibitor (PCI) and alpha 1-antitrypsin (alpha 1AT). Chimpanzees were infused with a bolus of activated factor X (F.Xa) together with vesicles of phosphatidylcholine and phosphatidylserine (PCPS). Pre- and post-infusion plasma samples were analyzed using enzyme linked immunosorbent based assays (ELISA) for PC and APC complexes, and immunoblotting of PC from nondenaturing polyacrylamide gel electrophoresis. Within 2 minutes of infusion, a 60% decrease in nonactivated PC zymogen (PCz) levels was observed. This coincided with a precipitous drop in plasma activities of cofactors VIIIa and Va. In contrast, total PC antigen (PCt) levels decreased by only 1%, indicating APC generation. Complexes of APC with both PCI and alpha 1AT were observed on immunoblots, and further identified and quantified using a sandwich ELISA employing antibodies to both PC and these inhibitors. The distribution of APC between these two inhibitors varied with the dose of F.Xa/PCPS infused. At a dose of F.Xa/PCPS of 24.05 pmol and 37.70 nmol/kg, respectively, an initial spike of APC generation, associated with decreases in the levels of factors VIIIa and Va, was noted but dissipated over the next 30 minutes. During this period, APC/inhibitor complexes appeared with the levels of APC-PCI and APC-alpha 1AT reaching 8.5 nmol/L and 2.2 nmol/L by 30 minutes, respectively. In contrast, at a higher dose of F.Xa/PCPS of 36.60 pmol and 56.30 nmol/Kg respectively, complexes of APC-alpha 1AT appeared rapidly and reached a level of 6 nmol/L by 30 minutes postinfusion, whereas APC-PCI complexes were only present at a concentration of 3.4 nmol/L by this time. Additional experiments with lower doses of F.Xa/PCPS suggest that PCI is the preferred inhibitor of APC, but as the availability of this inhibitor becomes limiting, alpha 1AT plays an increasingly crucial role as a secondary inhibitor of endogenously generated APC. Moreover, evidence is presented suggesting the existence of additional inhibitor(s) of APC that may have a role similar to alpha 1AT.
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Fosse, Ethan, and Christopher Winship. "Analyzing Age-Period-Cohort Data: A Review and Critique." Annual Review of Sociology 45, no. 1 (2019): 467–92. http://dx.doi.org/10.1146/annurev-soc-073018-022616.

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Age-period-cohort (APC) analysis has a long, controversial history in sociology and related fields. Despite the existence of hundreds, if not thousands, of articles and dozens of books, there is little agreement on how to adequately analyze APC data. This article begins with a brief overview of APC analysis, discussing how one can interpret APC effects in a causal way. Next, we review methods that obtain point identification of APC effects, such as the equality constraints model, Moore-Penrose estimators, and multilevel models. We then outline techniques that entail point identification using measured causes, such as the proxy variables approach and mechanism-based models. Next, we discuss a general framework for APC analysis grounded in partial identification using bounds and sensitivity analyses. We conclude by outlining a general step-by-step procedure for conducting APC analyses, presenting an empirical example examining temporal shifts in verbal ability.
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Dissertations / Theses on the topic "APC model"

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Mtotywa, Matolwandile Mzuvukile. "Productivity measurement and its relationship to quality in a South African Minting Company." Thesis, University of South Africa, 2007. http://hdl.handle.net/10500/51.

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The aim of this study was to investigate a productivity measurement at the South African Minting Company and evaluate the relationship between productivity and quality. Special emphasis was given to profit-linked total factor model as the tool for measurement. This was encouraged by their ability to separate productivity, profitability and price recovery. Three models were selected and evaluated. These models American Productivity Center (APC) Model, “Profitability = productivity + price recovery” (PPP) model and multi-factor productivity measurement model (MFPMM). APC model was selected as the suitable model because of its simplicity, easy to set up, its ability to produce both financial and non financial data, and allow for route cause analysis with expert system, and more insight for the manager with Microsoft Excels’ What if analysis “Goal seek”. APC model was set up for four periods, from 1 April 2004 to 30 September 2007. The overall profitability results of the circulation coins profit center show an overall positive contribution. There was a break-even of the price recovery for 2006 financial year (period 2). In 2007 financial year (period 3), there was a negative contribution, and this improved to almost break-even in the six month period during this 2008 financial year (period 4). This means there was much more inflation on input resources and the recovery was not fully realised in the price of goods sold. Individual input costs show that the negative price recovery is culminating from material, labour and energy costs contributions. There is a plausible explanation for material and labour, but not for energy. The metal volatility is the underlying cause of the price variation. Labour variation was a company strategy to adjust employee to higher percentiles. Productivity was always positive with the highest contribution in the current financial year (period 4). This means that the profitability at SA Mint has been driven by productivity in the past two financial years. iv Survey of the questionnaire shows average scores for productivity and quality. It is noteworthy, that the lowest mean score for productivity is for the statement “Products are produced in error-free process”. This is a productivity quality measure. In addition, the same variable shows r2 value of 0.42. A conclusion is that even though productivity and quality are highly correlated and show a highly positive relationship, there is a concern on quality in the company. A link can be made that low price recovery becomes more difficult when the quality is not always good. Defective product is a cost, because the product does not reach the customer and if the product is reworked it is still a cost, though low, but more importantly it decreases the available capacity. This study was successful in setting up APC model and producing data that is worthy to the company and academic world. Finally, this study was successful in its quest to establish the relationship between productivity and quality.
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Elahi, Eiram. "QTL mapping of Apc modifiers in an ApcMin/+ mouse model of spontaneous and irradiation-induced intestinal adenomas." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8717.

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BACKGROUND: Radiation exposure to the abdominal region causes intestinal toxicity and is also capable of inducing colorectal cancers (CRC). Genotype-phenotype studies provide some evidence explaining the variation in familial adenomatous polyposis (FAP) patients caused by modifiers of adenomatous polyposis coli (APC). This study aims to extend our understanding of irradiation-induced modifiers of ApcMin/+ mice and CRC. METHODS: By using a pre-existing backcross between recombinant inbred line of ApcMin/+ mice to the irradiation sensitive inbred BALB/c mouse, we obtained panels of 2Gy-irradiated and sham-irradiated N2 ApcMin/+ mice for genotyping with a genome-wide panel of microsatellites markers. Using the number of adenomas in different intestinal segments to represent polyp multiplicity, we carried out a genome wide quantitative trait loci (QTL) scan followed by statistical epistasis modelling and bioinformatics analysis. RESULTS: We identified five significant QTLs responsible for radiation induced tumour multiplicity in the upper small intestine defined as Mom (Modifier of Min) radiation-induced polyposis (Mrip1-5) on chromosome 2 (LOD 2.8, p = 0.0003), two regions within chromosome 5 (LOD 5.2, p=0.00001, 6.2, p=0.00001) and two regions within chromosome 16 (LOD 4.1, p=4x10-5 and 4.8, p=0.00001). Suggestive QTLs were found for sham-irradiated mice on chromosomes 3, 6 and 13 (LOD 1.7, 1.5 and 2.0 respectively; p,0.005). Two significant QTLs were detected in the 2large intestine on chromosome 2 and 7 (LOD 2.7, p=1.2x10-3 and 2.2, p=1.2x10-3, 12 respectively). Using statistical epistasis modelling and logical selection of target genes though in silico sequence based on BALB/c specific non-synonymous polymorphisms which are predicted deleterious we selected target genes and further eliminated genes by sequencing and mRNA expression. CONCLUSIONS: Our study locates the QTL regions responsible for increased radiation-induced intestinal tumorigenesis in ApcMin/+ mice and identifies candidate genes with predicted functional polymorphisms that are involved in spindle checkpoint and chromosomal stability (Bub1b, Bub1r, and Casc5), Wnt pathway (Tiam1, Rac1), DNA repair (Recc1 and Prkdc) and inflammation (Duox2, Itgb2l and Cxcl5).
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Wong, Wing Yan. "Proteomics analysis of anti-cancer effects of gynostemma pentaphyllum saponins in Apc min/+ colorectal cancer mouse model." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1421.

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Duh, Camilla, and Carsten Daub. "A Model to Enhance the Effectiveness of Machining Centers with Automatic Multi-Pallet Changers: a Case Study." Thesis, Växjö University, School of Technology and Design, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-938.

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<p>The purpose of this thesis is to develop a model to enhance the effectiveness of machining centers with multi-pallet automatic pallet changers (APCs). From critical literature review no existing theories within this field were found. The multi-pallet APC allows multi-setups and a more flexible sequencing of jobs. The model together with the developed heuristic scheduling algorithm with the objective to minimize the total weighted tardiness can be used to plan in n jobs on m pallets in a shop-floor. The right maintenance policy ensures a high availability, which together with the program guarantees a high level of utilization of the machinery. Consequently the effectiveness will be enhanced. A case study approach was used to test the model at Växjöfabriken in Sweden, which treats cast material. The results of this case study are a more effective utilization of the machines with decreased tardiness costs, increased customers’ satisfaction and goodwill of the company. The contribution of this thesis is a model with a flexible, adjustable and expandable heuristic scheduling algorithm, which can be applied in all manufacturing companies using machining centers with multi-pallet APCs.</p><br><p>Syftet med denna uppsats är att utveckla en modell för att förbättra effektiviteten av maskincentra med automatiska palletväxlare (APCs) för multi-palleter. När en kritisk litteratursökning genomfördes hittades inga relevanta teorier inom det aktuella området. Multi-pallet APC tillåter att många jobb kan förberedas samtidigt och gör planeringen av jobben mer flexibel. Modellen, tillsammans med den utvecklade heuristiska planeringsalgoritmen med målet att minimera den totala viktade förseningen, kan användas för att planera in n jobb med m palleter på ett verkstadsgolv. Rätt underhålls policy försäkrar en hög tillgänglighet vilket tillsammans med programmet garanterar en hög utnyttjandenivå av maskinerna. Som följd kommer effektiviteten att höjas. En fallstudie utfördes på Växjöfabriken i Sverige för att utvärdera modellen, på företaget efterbehandlas gjutgods. Resultatet från denna fallstudie blev ett effektivare utnyttjande av maskinerna, med minskade förseningskostnader, ökad kundtillfredställelse och goodwill för företaget. Denna uppsats bidrar med en modell och en flexibel, anpassningsbar och utvecklingsbar heuristisk planeringsalgoritm, vilken kan användas i alla industriföretag som använder maskincentra med multi-pallet APCs.</p>
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Jordan, Sumanas W. "A mathematical model of tissue factor-induced blood coagulation: discrete sites of initiation and regulation under conditions of flow." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33907.

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A mathematical model of blood coagulation under defined flow conditions, initiated and modulated by spatially discrete regions of surface bound tissue factor (TF) and thrombomodulin (TM), respectively, is presented. The model incorporates fluid phase and surface-associated reactions of the extrinsic, intrinsic, and common pathways, as well as three inhibitory pathways. The spatially heterogeneous model is formulated by finite element method, and an effective prothrombotic zone, which quantifies the spatial propagation of thrombin generation is defined. Characteristic features of coagulation are simulated under physiologic conditions, and the behavior of the system in response to perturbations in TF and TM surface densities, TF site dimensions, and wall shear rate is explored. The major findings of these studies include: (i) The model system responds in an 'all-or-none', threshold-like manner to changes in model parameters. (ii) It was found that prothrombotic effects may extend significantly beyond the dimensions of the spatially discrete site of TF expression in both axial and radial directions. (iii) The relationship between the length of the effective prothrombotic zone and the interval distance between tandem sites of TF expression dictate the net response of the system. Additive prothrombotic effects of sub-clinical lesions as well as suppressive antithrombotic effects of intervening TM-containing regions were observed. Secondly, the computational model is applied to calculate an individualized, systems-based metric of clotting potential for 210 pre-menopausal women in the Leiden Thrombophilia Study (LETS). The simulated variable was found to be a highly predictive parameter for deep venous thrombosis risk.
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Orhun, Eda, and Blanka Grubjesic. "Value at Risk (VaR) Method : An Application for Swedish National Pension Funds (AP1, AP2, AP3) by Using Parametric Model." Thesis, University of Skövde, School of Technology and Society, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-129.

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<p>Value at Risk (VaR) approach has been extensively used by investment and commercial banks since its development by JP Morgan in 1990s. As time passes, it has become interesting to investigate whether VaR could be used also by other financial intermediaries like pension funds and insurance companies. The aim of this paper is to outline Value at Risk (VaR) methodology by giving more emphasis on parametric approach which is used for empirical section and to investigate the applicability and usefulness of VaR in pension funds. After providing theoretical framework for VaR approach, the paper continues with pension fund systems in general and especially highlights AP funds of Swedish National pension fund system by trying to show why VaR could be an invaluable risk management tool for these funds together with other traditional risk measures used. Based on this given theoretical frame, a practical application of VaR –parametric or covariance/variance method- is executed on 50 biggest investments in the fixed income and equity portfolios of three selected Swedish national pension funds – AP1, AP2 and AP3. Results of one day VaR (DEAR) estimations on 30/12/2005 for each fund have been presented and it is aimed to show the additional information that could be obtained by using VaR and which is not always apparent from other risk measures employed by funds. According to the two traditional risk measures which are active risk and Sharpe ratio; AP2 and AP3 lie in the same risk level for 2005 which can create a contradiction by considering their different returns. On the other hand, obtained DEAR estimates show their different risk exposures even with the 50 biggest investments employed. The results give a matching relationship between return of funds and DEAR estimates meaning that; the fund with the highest return has the highest DEAR value and the fund with the lowest return has the lowest DEAR value; which is consistent with the main rule- “higher risk, higher return”. Thus, we can conclude that VaR could be applied additionally to get a better picture about real risk exposures and also to get valuable information on expected possible loss together with other traditional risk measures used.</p><p>Key words: Value at Risk, DEAR, Pension funds, Risk management, Swedish pension plan, AP1, AP2, AP3</p>
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Al-Mashat, Alex. "Comparison of Multiple Models for Diabetes Using Model Averaging." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448168.

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Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. Glycated hemoglobin (HbA1c) is a common biomarker used by models within antihyperglycemic drug development, as it reflects the average plasma glucose level over the previous 8-12 weeks. There are five different nonlinear mixed-effects models that describes HbA1c-formation. They use different biomarkers such as mean plasma glucose (MPG), fasting plasma glucose (FPG), fasting plasma insulin (FPI) or a combination of those. The aim of this study was to compare their performances on a population and an individual level using model averaging (MA) and to explore if reduced trial durations and different treatment could affect the outcome. Multiple weighting methods were applied to the MA workflow, such as the Akaike information criterion (AIC), cross-validation (CV) and a bootstrap model averaging method. Results show that in general, models that use MPG to describe HbA1c-formation on a population level could potentially outperform models using other biomarkers, however, models have shown similar performance on individual level. Further studies on the relationship between biomarkers and model performances must be conducted, since it could potentially lay the ground for better individual HbA1c-predictions. It can then be applied in antihyperglycemic drug development and to possibly reduce sample sizes in a clinical trial. With this project, we have illustrated how to perform MA on the aforementioned models, using different biomarkers as well as the difference between model weights on a population and individual level.
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Schenk, Judith A. "Criteria for Evaluating Model Deficiency for Groundwater Models and the Effects of Eliminating Deficient Models on Multi Model Analysis Using AICc, KIC, AIC, and BIC." Thesis, Colorado School of Mines, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10266759.

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<p> Multi-model analysis (MMA) considers multiple model interpretations of a system. MMA provides a more realistic assessment of uncertainty associated with model predictions because both uncertainty of individual models and uncertainty associated with different model structures are considered. Models are evaluated for the strength of evidence that they represent an unknown system using different Information Criteria (IC) equations. IC equations are designed to assess the likelihood that a model in a set of models represents the true but unknown system. IC equations do not include a component which identifies a deficient model. Therefore, inclusion of deficient models in the set of models leads to poor model-averaged results. Evaluation of models to assess whether available observation data sufficiently support the model structure is an important step in MMA. Measures for evaluating models include: 1) failure to reach proper convergence during non-linear regression; 2) unreasonable parameter estimates; 3) unreasonable confidence intervals on parameters or a coefficient of variation greater than ten for one or more parameters; 4) high correlations between parameters; 5) determinant of the correlation matrix less than 1x10<sup> -12</sup>; 6) condition number of the Jacobian matrix greater than 2000; and 7) unreasonable confidence intervals on predictions.</p><p> Experiments presented herein are designed to evaluate how components of AIC, AICc, BIC, and KIC rank models and assign model probabilities, and to demonstrate how removing deficient models improves MMA results. Synthetic models are used to represent true but unknown systems in contrast to experimental models that are created to simulate a simplified version of the unknown system based on observation data taken from the synthetic models. AIC, AICc, BIC, and KIC generally assign high probability to deficient models. AICc generally assigns high probability to deficient models if 1) there are many observation data or 2) there are few observation data and the model fits the data well. KIC generally assigns high probability to deficient models because these models have low Fisher Information. AIC and BIC are influenced by the goodness-of-fit and are more likely to assign high probability to more complex models because these models are generally over-fitted. Removing deficient models results in improved MMA results using AIC, AICc, BIC and KIC.</p><p>
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Kooshkghazi, Mahshid Deghan. "Chemoprevention of intestinal cancer : dietary and pharmaceutical interventions in mutant Apc mouse models." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388729.

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Correia, Gonçalo Emanuel Coimbra Lamas Pereira. "Gestão de stocks numa unidade de ressonância magnética." Master's thesis, Instituto Superior de Economia e Gestão, 2011. http://hdl.handle.net/10400.5/3476.

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Mestrado em Gestão e Estratégia Industrial<br>Nos últimos anos a gestão de stocks tornou-se numa ferramenta fundamental para os prestadores de cuidados de saúde, que procuram a racionalização de custos com medicamentos e materical clínico, através de uma maior eficiência operacional. Este trabalho visa o estudo da relação entre classificações e modelos de gestão de stocks, e ilustra a sua aplicação em prestadores de cuidados de saúde, na área da imagiologia, em particular numa unidade de ressonância magnética. Neste estudo optou-se por uma classificação de stocks baseada em métodos analíticos, a classificação ABC, e uma classificação de stocks com base no conhecimento e experiência do gestor de stocks, a classificação XYZ, procurando definir políticas de gestão de stocks mais fiáveis, que se traduzam em manter o nível de stock correcto para ir ao encontro das necessidades, ao menor custo. Os modelos de gestão de stocks, procuram ajudar a responder a questões como quanto e quando repor os stocks, com o objectivo de escolher a melhor solução que corresponde a um custo total de aprovisionamento anual mínimo. Neste estudo optou-se pelo modelo de revisão contínua que proporciona um controlo constante e pelo modelo de revisão periódica para uma monitorização mais espaçada no tempo. Com base nestes estudos, propôs-se uma classificação mista ou tabela de políticas de gestão de stocks e analisou-se o seu impacto num prestador de cuidados de saúde.<br>In recent years, stock management has become a fundamental tool for healthcare providers who seek to rationalize drug and clinical material costs, through greater operational efficiency. This work aims to study the relationship between ratings and models of stock management, and to illustrate its application in healthcare providers in the area of diagnostic imaging, particularly in a magnetic resonance unit. In this study we chose a classification of stocks based on analytical methods, ABC classification, supplemented by knowledge and experience of the stock manager, XYZ classification, trying to define policies for stock management more reliable, which result in maintaining the level stock proper to meet the needs at the lowest cost. The models of stock management, seeking to help answer questions like how much and when to replenish stocks in order to choose the best solution that corresponds to a minimum total cost of the annual supply. In this study we opted for the continuous review model that provides a constant monitoring and periodic review model for monitoring more spaced in time. Based on these studies, we proposed a table stock management policy and discussed its impact in a healthcare provider.
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Books on the topic "APC model"

1

Elina, Ol'ga. The concept of priority development of the export of products of agro-industrial complex of Russia until 2024. INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1023826.

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The book describes the development of resulting research opportunities and prospects of promoting the products of agro-industrial complex (AIC) of Russia in the international markets. The authors ' study showed that Russia continues to increase its place in world trade of agricultural products. &#x0D; Presents the author's concept of increasing exports of agricultural products to Russia to $ 45 billion by 2024, identified strategic options, and proposed development model of export agriculture, the expedience, methods and instruments of realization of measures of state support of export of agricultural products.&#x0D; For a wide range of readers interested in the development and export of the APC.
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Ali, H. M. J. Static model of an A.C. circuit breaker. UMIST, 1994.

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Ciok, Zbigniew. Modele matematyczne łuku łączeniowego. Państwowe Wydawn. Nauk., 1987.

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Sliwinski, B. A model of U.S. Army Materiel Command (AMC) energy consumption. US Army Corps of Engineers, Construction Engineering Research Laboratory, 1986.

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Pusan, Korea) APCN Meeting 2004 (2004. Fourth APCN Working Group Meeting, Third APCN Steering Committee Meeting. Korea Meteorological Administration, 2004.

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Schuweiler, Alan R. Greenberg's guide to American Flyer wide gauge. Greenberg Pub. Co., 1989.

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Fazenbaker, Jack. Greenberg's price guide and inventory checklist to American Flyer, S gauge. Greenberg Pub. Co., 1986.

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Faust, Jeff. Greenberg's American flyer track plans and operating instructions. Greenberg Pub. Co., 1989.

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Svehar, Gary T. American Flyer: S gauge parts lists and exploded diagrams, 1979-1991. Greenberg Pub. Co., 1991.

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C, Patterson James. Greenberg's guide to American Flyer S gauge. 3rd ed. Greenberg Pub. Co., 1988.

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Book chapters on the topic "APC model"

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Taketo, M. M. "Apc Gene Knockout Mice as a Model for Familial Adenomatous Polyposis." In Animal Models of Cancer Predisposition Syndromes. KARGER, 1999. http://dx.doi.org/10.1159/000062007.

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Iqbal, Anjum, and Mohd Aizani Maarof. "Towards Danger Theory Based Artificial APC Model: Novel Metaphor for Danger Susceptible Data Codons." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30220-9_13.

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Liu, Xinping, Xiwen Xue, and Mingwen Zheng. "The RBFNN ’s Application in Nonlinear System Model Based on Improved APC-III Algorithm." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13498-2_74.

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Pugh, Clifford A. "Sediment Transport Scaling for Physical Models." In Sedimentation Engineering. American Society of Civil Engineers, 2008. http://dx.doi.org/10.1061/9780784408148.apc.

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Good, Kenneth. "Elitism’s Place in the ANC." In The Liberal Model and Africa. Palgrave Macmillan UK, 2002. http://dx.doi.org/10.1057/9780230001138_4.

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Tschudi, Finn, and David Winter. "The ABC Model Revisited." In Personal Construct Methodology. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119953616.ch4.

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Bucanek, James. "Model Citizen." In Learn iOS App Development. Apress, 2013. http://dx.doi.org/10.1007/978-1-4302-5063-0_8.

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Bucanek, James. "Model Citizen." In Learn iOS 8 App Development. Apress, 2014. http://dx.doi.org/10.1007/978-1-4842-0208-1_8.

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Doursat, Christophe, and Joël Priolon. "The Cox, Ross and Rubinstein model." In Financial Markets for Commodities. John Wiley & Sons, Inc., 2019. http://dx.doi.org/10.1002/9781119579274.app.

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Groce, Alex, Doron Peled, and Mihalis Yannakakis. "AMC: An Adaptive Model Checker." In Computer Aided Verification. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-45657-0_44.

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Conference papers on the topic "APC model"

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Morisawa, Toshihiro, Hiromichi Kobayashi, and Yukio Takeda. "Non-Linear Process Model for CMP-APC." In 2011 International Conference on Management and Service Science (MASS 2011). IEEE, 2011. http://dx.doi.org/10.1109/icmss.2011.5999338.

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Xu, Jingqi, Haode Liu, and Jing Teng. "Optimization Model for Bus Timetable Based on APC." In Eighth International Conference of Chinese Logistics and Transportation Professionals (ICCLTP). American Society of Civil Engineers, 2009. http://dx.doi.org/10.1061/40996(330)659.

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Shaowu Cheng, Baoyi Liu, and Botao Zhai. "Bus arrival time prediction model based on APC data." In 6th Advanced Forum on Transportation of China (AFTC 2010). IET, 2010. http://dx.doi.org/10.1049/cp.2010.1123.

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Baloch, Mohammad Adnan, I. Ismail, Noor Hazrin Hany binti Mohamad Hanif, and T. M. Baloch. "ANFIS identification model of an Advanced Process Control (APC) pilot plant." In Advanced Systems (ICIAS 2010). IEEE, 2010. http://dx.doi.org/10.1109/icias.2010.5716224.

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Mao, Ziqiang J., and Issi Geier. "Model-based fault detection and metrology error rejection in registration APC system." In Microlithography 2004, edited by Kenneth W. Tobin, Jr. SPIE, 2004. http://dx.doi.org/10.1117/12.536810.

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Chen, Wei-Ya, and Zhi-Ya Chen. "A Simulation Model for Transit Service Unreliability Prevention Based on AVL-APC Data." In 2009 International Conference on Measuring Technology and Mechatronics Automation. IEEE, 2009. http://dx.doi.org/10.1109/icmtma.2009.77.

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Zheng, Mingwen, and YanPing Zhang. "An Improved APC-III Algorithm's RBFNN and its Application in the Nonlinear System Model." In 2010 International Conference on Intelligent Computation Technology and Automation (ICICTA). IEEE, 2010. http://dx.doi.org/10.1109/icicta.2010.202.

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Tumlinson, Alexandre R., Jennifer K. Barton, James McNally, et al. "Imaging APC/Min(+/−) colon cancer model mice with ultrahigh resolution endoscopic FD-OCT at 800nm." In Frontiers in Optics. OSA, 2005. http://dx.doi.org/10.1364/fio.2005.fmc1.

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Samaras, Patroklos, Anestis Fachantidis, Grigorios Tsoumakas, and Ioannis Vlahavas. "A prediction model of passenger demand using AVL and APC data from a bus fleet." In PCI '15: 19th Panhellenic Conference on Informatics. ACM, 2015. http://dx.doi.org/10.1145/2801948.2801984.

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Wojtal, Daria, Roopali Chaudhary, Kyster K. Nanan, Simona Morone, and Juliet M. Daniel. "Abstract 1302: Effect of intestinal-specific Kaiso overexpression on the APC MIN/+ mouse colon cancer model." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1302.

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Reports on the topic "APC model"

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Chu, Xuehao. Validating T-BEST Models with 100% APC Counts. University of South Florida, 2007. http://dx.doi.org/10.5038/cutr-nctr-rr-2005-02.

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Berzins, Valdis. Acoustic Simulation API Requirements Model. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada442126.

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Gormley, M., and S. O'Day. An Updated AP2 Beamline TURTLE Model. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/983972.

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Watanabe, R., and R. Han. Upgrading of Agc Sediment Transport Model. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1987. http://dx.doi.org/10.4095/126108.

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Roth, Christopher. AE9/AP9/SPM Radiation Environment Model: User's Guide. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada603883.

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Whelan, Paul. AE9/AP9/SPM Model Application Programming Interface, Version 1.00.000. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada603361.

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Hamm, L. L. APT Blanket System Model Based on Initial Conceptual Design - Integrated 1D TRAC System Model. Office of Scientific and Technical Information (OSTI), 1998. http://dx.doi.org/10.2172/4915.

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Bennett, M. V., and J. M. Bennett. Aircraft Engine/APU Fire Extinguishing System Design Model (HFC-125). Defense Technical Information Center, 1997. http://dx.doi.org/10.21236/ada373212.

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Hamm, L. L. APT Blanket Detailed Bin Model Based on Initial Plate-Type Design -3D FLOWTRAN-TF Model. Office of Scientific and Technical Information (OSTI), 1998. http://dx.doi.org/10.2172/4913.

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Krakowski, R. A. APT cost scaling: Preliminary indications from a Parametric Costing Model (PCM). Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/39121.

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