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Journal articles on the topic 'Antisolvent addition crystallizations'

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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

Bouich, Amal, Julia Marí-Guaita, Bernabé Marí Soucase, and Pablo Palacios. "Manufacture of High-Efficiency and Stable Lead-Free Solar Cells through Antisolvent Quenching Engineering." Nanomaterials 12, no. 17 (August 23, 2022): 2901. http://dx.doi.org/10.3390/nano12172901.

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Antisolvent quenching has shown to significantly enhance several perovskite films used in solar cells; however, no studies have been conducted on its impact on MASnI3. Here, we investigated the role that different antisolvents, i.e., diethyl ether, toluene, and chlorobenzene, have on the growth of MASnI3 films. The crystallinity, morphology, topography, and optical properties of the obtained thin films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), photoluminescence (PL) measurements, and UV–visible spectroscopy. The impact of the different antisolvent treatments was evaluated based on the surface homogeneity as well as the structure of the MASnI3 thin films. In addition, thermal annealing was optimized to control the crystallization process. The applied antisolvent was modified to better manage the supersaturation process. The obtained results support the use of chlorobenzene and toluene to reduce pinholes and increase the grain size. Toluene was found to further improve the morphology and stability of thin films, as it showed less degradation after four weeks under dark with 60% humidity. Furthermore, we performed a simulation using SCAPS-1D software to observe the effect of these antisolvents on the performance of MASnI3-based solar cells. We also produced the device FTO/TiO2/MASnI3/Spiro-OMeTAD/Au, obtaining a remarkable photoconversion efficiency (PCE) improvement of 5.11% when using the MASnI3 device treated with chlorobenzene. A PCE improvement of 9.44% was obtained for the MASnI3 device treated with toluene, which also showed better stability. Our results support antisolvent quenching as a reproducible method to improve perovskite devices under ambient conditions.
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2

Ward, Martin R., and Iain D. H. Oswald. "Antisolvent addition at extreme conditions." CrystEngComm 21, no. 30 (2019): 4437–43. http://dx.doi.org/10.1039/c9ce00365g.

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3

Falcon, Javier A., and Kris A. Berglund. "Monitoring of Antisolvent Addition Crystallization with Raman Spectroscopy." Crystal Growth & Design 3, no. 6 (November 2003): 947–52. http://dx.doi.org/10.1021/cg0340446.

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4

Nonoyama, Nobuaki, Keigo Hanaki, and Yasuaki Yabuki. "Constant Supersaturation Control of Antisolvent-Addition Batch Crystallization." Organic Process Research & Development 10, no. 4 (July 2006): 727–32. http://dx.doi.org/10.1021/op0600052.

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5

Deviana Christianty, Sola Fide Gavra, and Zuhrina Masyithah. "KRISTALISASI LIKOPEN DARI BUAH TOMAT (Lycopersicon esculentum) MENGGUNAKAN ANTISOLVENT." Jurnal Teknik Kimia USU 4, no. 4 (December 24, 2015): 39–45. http://dx.doi.org/10.32734/jtk.v4i4.1512.

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Studies on the utilization of lycopene had been conducted to determine the effect of comparison feed and solvent (F/S) and the addition of methanol for extraction of lycopene from tomatoes using mixture solvent of hexane:ethyl acetate (1:1) followed by crystallization antisolvent. In this research, ripe tomatoes juice was used with volume 150 ml. Lycopene extract was obtained through extraction method at temperature of 70 °C and the stirring speed 7 rpm. The other method was by the addition of methanol as antisolvent for crystallization. As for changing variable in this study were a comparison of feed and solvent (F/S) 1:2; 1:2.5; 1:3; 1:3.5; 1:4 and 1:4,5, and the volume of methanol as antisolvent were 50 ml, 100 ml, 150 ml and 200 ml. The results of this research about influence of feed and solvent to lycopene yield extracted obtained at the optimum condition 1:4 with a volume of 200 ml antisolvent. Whereas the influence about addition of methanol as antisolvent as an agent of precipitation and maximum condition occurs on volume of 200 ml. Wavelength analysis of C=C linkage with Fourier Transform Infrared (FT-IR) detected at wavenumber 1519,91 cm-1, CH2 linkage detected at wavenumber 1446,61 cm-1, R-CH=CH-R linkage detected at wavenumber 979,84 cm-1. While, C-C and C-CH linkage detected at wavenumber 1138 and 1373,32 cm-1.
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6

Sibanda, Jonathan, Jemitias Chivavava, and Alison Emslie Lewis. "Crystal Engineering in Antisolvent Crystallization of Rare Earth Elements (REEs)." Minerals 12, no. 12 (December 1, 2022): 1554. http://dx.doi.org/10.3390/min12121554.

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Antisolvent crystallization is a separation technology that separates the solute from the solvent by the addition of another solvent, in which the solute is sparingly soluble. High yields are achieved by using higher antisolvent-to-aqueous ratios, but this generates higher supersaturation, which causes excessive nucleation. This results in the production of smaller particles, which are difficult to handle in downstream processes. In this work, the effect of varying the organic (antisolvent)-to-aqueous (O/A) ratio and seed loading on the yield, particle size distribution, and morphology of neodymium sulphate product, during its recovery from an aqueous leach solution using antisolvent crystallization, was investigated. A batch crystallizer was used for the experiments, while ethanol was used as an antisolvent. Neodymium sulphate octahydrate [Nd2(SO4)3.8H2O] seeds were used to investigate the effect of seed loading. It was found that particle sizes increased as the O/A ratio increased. This was attributed to the agglomeration of smaller particles that formed at high supersaturation. An O/A ratio of 1.4 resulted in higher yields and particles with a plate-like morphology. The increase in yield was attributed to the increased interaction of ethanol molecules with the solvent, which reduced the solubility of neodymium sulphate. Increasing the seed loading resulted in smaller particle sizes with narrow particle size distribution and improved filtration performance. This was attributed to the promotion of crystal growth and suppression of agglomeration in the presence of seeds.
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7

Zhang, Yu, Dongdong Feng, Jianmin Gao, Qian Du, and Shaohua Wu. "Thermodynamic properties in ternary system of NH4HCO3–H2O–ethanol based on antisolvent method to strengthen crystallization of carbonized ammonia." Adsorption Science & Technology 37, no. 1-2 (December 14, 2018): 127–38. http://dx.doi.org/10.1177/0263617418817602.

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One of the main challenges of the ammonia-based CO2 capture process is how to further reduce the regeneration energy consumption. An antisolvent crystallization method was proposed to strengthen the crystallization process of carbonized ammonia, and heating the crystal products instead of rich solution can greatly reduce renewable energy consumption. The main component of the crystal product was NH4HCO3 analyzed by X-ray diffraction. Therefore, it is very important to study the thermodynamic properties of ammonium bicarbonate in the ternary system of NH3–H2O–ethanol. In this paper, the solubility curves under different temperature and solvent compositions were determined by static method and the mathematical model of solubility was established. The effects of the addition of ammonium carbamate which was produced in the initial stage of the CO2 absorption process and the addition of ammonia on the solubility in ternary system of NH4HCO3–H2O–ethanol were studied. The dissolution heat was also calculated in the end. The research of this article has a guiding significance for the antisolvent method to strengthen the crystallization of carbonized ammonia of ammonia-based carbon capture technology. It is helpful to further strengthen the crystallization process of low carbonized ammonia and improve the crystallization yield.
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8

Sangwal, Keshra, and Ewa Mielniczek-Brzóska. "Antisolvent crystallization of aqueous ammonium dihydrogen phosphate solutions by addition of methanol." Journal of Crystal Growth 451 (October 2016): 139–49. http://dx.doi.org/10.1016/j.jcrysgro.2016.07.027.

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9

Falcon, Javier A., and Kris A. Berglund. "In Situ Monitoring of Antisolvent Addition Crystallization with Principal Components Analysis of Raman Spectra." Crystal Growth & Design 4, no. 3 (May 2004): 457–63. http://dx.doi.org/10.1021/cg034206y.

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10

Lee, Tu, Kuan Lin Yeh, Jia Xian You, Ya Chi Fan, Yun Sheng Cheng, and Dhanang Edy Pratama. "Reproducible Crystallization of Sodium Dodecyl Sulfate·1/8 Hydrate by Evaporation, Antisolvent Addition, and Cooling." ACS Omega 5, no. 2 (January 6, 2020): 1068–79. http://dx.doi.org/10.1021/acsomega.9b03067.

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11

Sangwal, Keshra, and Ewa Mielniczek-Brzóska. "Antisolvent crystallization of aqueous ammonium dihydrogen phosphate solutions by addition of acetone at different rates." Crystal Research and Technology 51, no. 8 (July 12, 2016): 475–90. http://dx.doi.org/10.1002/crat.201600071.

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12

Sangwal, Keshra, and Ewa Mielniczek-Brzóska. "Effect of addition of different antisolvents on the crystallization of aqueous ammonium dihydrogen phosphate solutions." Crystal Research and Technology 52, no. 8 (June 6, 2017): 1600361. http://dx.doi.org/10.1002/crat.201600361.

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13

Zhang, Bingyu, Dayong Liu, Peng Chen, Wanqiang Liu, Jianxun Zhao, Huicheng Li, and Heng Liu. "Improved perovskite crystallization via antisolvent-assisted processed using additive engineering for efficient perovskite solar cells." Journal of Alloys and Compounds 855 (February 2021): 157396. http://dx.doi.org/10.1016/j.jallcom.2020.157396.

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14

Kitamura, Mitsutaka. "Thermodynamic stability and transformation of pharmaceutical polymorphs." Pure and Applied Chemistry 77, no. 3 (January 1, 2005): 581–91. http://dx.doi.org/10.1351/pac200577030581.

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The thermodynamic stability and transformation of pharmaceutical polymorphs was investigated, especially those of the thiazole derivative pharmaceutical, 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid (BPT). The influence of methanol compositions in solvents and temperature on the solubility and the transformation behavior of BPT was clarified. The transformation behavior was explained by the chemical potential difference between the stable and metastable forms. It was shown that a specific solute–solvent interaction contributes to the preferential nucleation and growth of the stable or metastable forms and influences the transformation behaviors. The solubility of BPT of the solvated crystals is much more influenced by the solvent compositions than the true polymorphs. The solubility ratio of the solvated crystals depends on the solvent composition, whereas the solubility ratio of the true polymorphs is considered to be independent of the solvents. The crystallization behavior was also investigated. The transformation rate after crystallization appeared to depend on the initial concentration of BPT and the addition rate of the antisolvent. The cause of this phenomenon was presumed to be a slight inclusion of the stable form in the metastable form.
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15

Yang, Fu, Muhammad Akmal Kamarudin, Putao Zhang, Gaurav Kapil, Tingli Ma, and Shuzi Hayase. "Enhanced Crystallization by Methanol Additive in Antisolvent for Achieving High-Quality MAPbI3 Perovskite Films in Humid Atmosphere." ChemSusChem 11, no. 14 (June 19, 2018): 2348–57. http://dx.doi.org/10.1002/cssc.201800625.

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16

Long, Barry, Kevin M. Ryan, and Luis Padrela. "Investigating Process Variables and Additive Selection To Optimize Polymorphic Control of Carbamazepine in a CO2 Antisolvent Crystallization Process." Organic Process Research & Development 24, no. 6 (April 13, 2020): 1006–17. http://dx.doi.org/10.1021/acs.oprd.9b00545.

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17

Zhou, Yanan, Shuyi Zong, Jie Gao, Chunsong Liu, and Ting Wang. "Solution-Mediated Polymorphic Transformation of L-carnosine from Form II to Form I." Crystals 12, no. 7 (July 21, 2022): 1014. http://dx.doi.org/10.3390/cryst12071014.

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In this study, L-carnosine was chosen as the model compound to systematically study solution-mediated polymorphic transformation by online experiment and theoretical simulation. Form II, a new polymorph of L-carnosine, was developed using an antisolvent crystallization method. The properties of form I and form II L-carnosine were characterized by powder X-ray diffraction, polarizing microscope, thermal analysis, and Raman spectroscopy. In order to explore the relative stability, the solubility of L-carnosine form I and form II in a (water + DMAC) binary solvent mixture was determined by a dynamic method. During the solution-mediated polymorphic transformation process of L-carnosine in different solvents, Raman spectroscopy was employed to detect the solid-phase composition of suspension in situ, and the gravimetric method was used to measure the liquid concentration. In addition, the effect of the solvent on the transformation process was evaluated and analyzed. Finally, a mathematical model of dissolution–precipitation was established to simulate the kinetics of the polymorphic transformation process based on the experimental data. Taking the simulation results and the experimental data into consideration, the controlling step of solution-mediated polymorphic transformation was discussed.
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18

Abouhakim, Hanane, Sten O. Nilsson Lill, Michael J. Quayle, Stefan T. Norberg, Ali Hassanpour, and Christopher M. Pask. "The crystal structure, morphology and mechanical properties of diaquabis(omeprazolate)magnesium dihydrate." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 76, no. 2 (March 24, 2020): 275–84. http://dx.doi.org/10.1107/s2052520620001249.

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The crystal structure of diaquabis(omeprazolate)magnesium dihydrate (DABOMD) in the solid state has been determined using single-crystal X-ray diffraction. Single crystals of DABOMD were obtained by slow crystallization in ethanol with water used as an antisolvent. The crystal structure shows a dihydrated salt comprising a magnesium cation coordinating two omeprazolate anions and two water molecules (W1) that are strongly bound to magnesium. In addition, two further water molecules (W2) are more weakly hydrogen-bonded to the pyridine nitrogen atom of each omeprazolate anion. The crystal structure was utilized to estimate key material properties for DABOMD, including crystal habit and mechanical properties, which are required for improved understanding and prediction of the behaviour of particles during pharmaceutical processing such as milling. The results from the material properties calculations indicate that DABOMD exhibits a hexagonal morphology and consists of a flat slip plane through the (100) face. It can be classed as a soft material based on elastic constant calculation and exhibits a two-dimensional hydrogen-bonding framework. Based on the crystal structure, habit and mechanical properties, it is anticipated that DABOMD will experience large disorder accompanied by plastic deformation during milling.
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19

Dong, Kailian, Hai Zhou, Meng Xiao, Pengbin Gui, Zheng Gao, Fang Yao, Wenlong Shao, et al. "Semi-transparent, high-performance lead-free Cs3Bi2I9 single crystal self-driven photodetector." Applied Physics Letters 120, no. 19 (May 9, 2022): 191102. http://dx.doi.org/10.1063/5.0090569.

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All-inorganic Bi-based perovskites have attracted much attention due to their excellent stability, environmentally friendly, and low-cost solution processability. However, due to the large exciton binding energy and small light absorption coefficient, the performance of the Bi-based perovskite photodetector (PD) is far behind of the traditional Pb-based perovskite PDs. In this work, the lead-free all-inorganic Cs3Bi2I9 (CBI) perovskite single crystal was synthesized by a space-confined antisolvent-assisted crystallization method for high-performance, semi-transparent, and self-driven PDs with an ITO/SnO2/CBI/PTAA/Au/ITO structure. Electrical and optical properties of Au/ITO transparent electrode were studied considering its figure of merit and device quantum efficiency through optimizing the Au thickness. Finally, our optimized semi-transparent device showed excellent self-driven performance with a large on/off ratio of ∼5700, a high responsivity of 52.06 mA/W, a high detectivity of >1012 Jones, and a large linear dynamic range of up to 140.7 dB. In addition, our device demonstrated excellent characteristics to the weak light detection and the long-term stability. The Au/ITO electrode was adopted and tailored to balance the device performance and transparency, which provides a good route for developing high-performance and transparent devices in the future.
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20

Yang, Fu, Muhammad Akmal Kamarudin, Putao Zhang, Gaurav Kapil, Tingli Ma, and Shuzi Hayase. "Cover Feature: Enhanced Crystallization by Methanol Additive in Antisolvent for Achieving High-Quality MAPbI3 Perovskite Films in Humid Atmosphere (ChemSusChem 14/2018)." ChemSusChem 11, no. 14 (July 13, 2018): 2265. http://dx.doi.org/10.1002/cssc.201801509.

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21

Rao, Guruprasad, Soheil Aghajanian, Tuomas Koiranen, Radosław Wajman, and Lidia Jackowska-Strumiłło. "Process Monitoring of Antisolvent Based Crystallization in Low Conductivity Solutions Using Electrical Impedance Spectroscopy and 2-D Electrical Resistance Tomography." Applied Sciences 10, no. 11 (June 4, 2020): 3903. http://dx.doi.org/10.3390/app10113903.

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Industrial process monitoring is an important field of research where different chemical processes are monitored and controlled. In this work, electrical impedance spectroscopy (EIS) was used to analyze antisolvent based crystallization of sucrose solutions. The impedance and phase spectra were recorded for four known sucrose concentrations in water, and for each case, four predetermined amounts of ethanol were added. As a result, sixteen different solutions involving sucrose solutions of different concentrations and ethanol to water ratios were analyzed. Significant differences were observed in the magnitude and phase spectra of the solutions in the frequency range of 50 kHz to 300 kHz. The experimentally obtained data from the EIS were converted into frequency response models. Three continuous-time transfer function models of the first-order, second-order, and a second-order with a zero were estimated and compared. In addition, a 2-D electrical resistance tomography (ERT) system with a low conductivity sensor unit was designed and tested with demineralized water, tap water and industrial food grade saturated sucrose solution. Non-conducting phantom and sugar crystals were observed within the saturated sucrose solution using the Bayesian reconstruction algorithm. These demonstrations have the potential to be developed into a multi-frequency ERT systems for monitoring the distribution of the crystals in the reactor. The EIS modality can be a complementary process analytical technology (PAT) tool indicating supersaturation status and provide quality assurance.
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22

Kalam, Mohd Abul, Muzaffar Iqbal, Abdullah Alshememry, Musaed Alkholief, and Aws Alshamsan. "Fabrication and Characterization of Tedizolid Phosphate Nanocrystals for Topical Ocular Application: Improved Solubilization and In Vitro Drug Release." Pharmaceutics 14, no. 7 (June 23, 2022): 1328. http://dx.doi.org/10.3390/pharmaceutics14071328.

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Positively charged NCs of TZP (0.1%, w/v) for ocular use were prepared by the antisolvent precipitation method. TZP is a novel 5-Hydroxymethyl-Oxazolidinone class of antibiotic and is effective against many drug-resistant bacterial infections. Even the phosphate salt of this drug is poorly soluble, therefore the NCs were prepared for its better solubility and ocular availability. P188 was found better stabilizer than PVA for TZP-NCs. Characterization of the NCs including the particle-size, PDI, and ZP by Zeta-sizer, while morphology by SEM indicated that the preparation technique was successful to get the optimal sized (151.6 nm) TZP-NCs with good crystalline morphology. Mannitol (1%, w/v) prevented the crystal growth and provided good stabilization to NC1 during freeze-drying. FTIR spectroscopy confirmed the nano-crystallization did not alter the basic molecular structure of TZP. DSC and XRD studies indicated the reduced crystallinity of TZP-NC1, which potentiated its solubility. An increased solubility of TZP-NC1 (25.9 µgmL−1) as compared to pure TZP (18.4 µgmL−1) in STF with SLS. Addition of stearylamine (0.2%, w/v) and BKC (0.01%, w/v) have provided cationic (+29.4 mV) TZP-NCs. Redispersion of freeze-dried NCs in dextrose (5%, w/v) resulted in a clear transparent aqueous suspension of NC1 with osmolarity (298 mOsm·L−1) and viscosity (21.1 cps at 35 °C). Mannitol (cryoprotectant) during freeze-drying could also provide isotonicity to the nano-suspension at redispersion in dextrose solution. In vitro release in STF with SLS has shown relatively higher (78.8%) release of TZP from NC1 as compared to the conventional TZP-AqS (43.4%) at 12 h. TZP-NC1 was physically and chemically stable at three temperatures for 180 days. The above findings suggested that TZP-NC1 would be a promising alternative for ocular delivery of TZP with relatively improved performance.
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23

Szczygielska, Joanna, Paweł Maksimowski, and Wincenty Skupiński. "Study of the effect the rate of addition of the antisolvent on the crystallization of the CL-20." Materiały Wysokoenergetyczne / High Energy Materials, December 10, 2019, 95–102. http://dx.doi.org/10.22211/matwys/0120e.

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In this paper, the effect of antisolvent addition rate on the yield and polymorphic purity of the obtained product, in order to optimise the 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) precipitation process using a solvent/antisolvent system, was determined. It was found that increased dispensing rate of the antisolvent results in increased supersaturation in the mother liquor. This, in turn, increases the nucleation rate. The prevalence of the process of creating new seeds reduces the growth rate of the crystal, which affects the size distribution of the final crystallisation product. Reducing the time of the process results in the transformation of the initially formed, kinetically stable polymorph β, into the thermodynamically stable ε form with a lower yield, than the yield obtained after increased time.
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24

Gadhiya, Dolly Tulsibhai, Jayvadan K. Patel, and Arti Arjanbhai Bagada. "An impact of nanocrystals on dissolution rate of Lercanidipine: Supersaturation and crystallization by addition of solvent to antisolvent." Future Journal of Pharmaceutical Sciences 7, no. 1 (June 29, 2021). http://dx.doi.org/10.1186/s43094-021-00271-x.

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Abstract Background Nanocrystals of any drug are pure solid drug particles with a mean diameter in nanometer range. Dissolution is a crucial factor for absorption of medicine in case of water-insoluble or poorly soluble drugs. The aim of this study was to develop nanocrystals of a hydrophobic drug, Lercanidipine, by addition of solvent to an antisolvent with high-speed homogenization to achieve dissolution and solubility enhancement. Addition of organic solvent to antisolvent results in genesis of nanosized particles due to fast nucleation process and rapid mixing. The nanosuspension was formulated using PVP K30 as a stabilizer. Further, nanosuspensions were lyophilized to convert into solid nanocrystals using mannitol as a cryoprotectant. The developed nanosuspensions were characterized for particle size, zeta potential, saturation solubility, and in vitro dissolution studies. Lyophilized solid nanocrystals were characterized for FTIR, SEM, XRD, and zeta potential (ζ). Results Central composite design was executed to study influence of amount of stabilizer and solvent to antisolvent ratio (independent variables) on particle size and % drug release at 10 min (dependent variables). The particle size of the developed Lercanidipine nanosuspensions were observed in the range of 302.00 ± 10.58 to 484.33 ± 6.51 nm measured by Zetatrac. A considerable increase was found in the solubility and dissolution rate of the nanocrystals as compared to pure drug. The drug release from Lercanidipine nanosuspensions was increased up to 88.95% within 10 min as compared to pure Lercanidipine which was only 21.53%. The X-ray diffraction study of lyophilized nanocrystals showed sharp and distinct peaks due to an increse in crystallinity of Lercanidipine Particle morphology was studied by scanning electron microscopy revealed that nanoprecipitated particles with lyophilization in the presence of mannitol exhibited dendrite needle-like crystals. Conclusion The nanocrystal development by antisolvent precipitation procedure using methanol as solvent, water as antisolvent, and low amounts of PVP K30 as stabilizer is a very promising and effective method to increase the dissolution rate of Lercanidipine. Graphical abstract
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25

Orehek, Jaka, Dušan Teslić, and Blaž Likozar. "Mechanistic Modeling of a Continuous Multi-Segment Multi-Addition Antisolvent Crystallization of Benzoic Acid in a Coiled Flow Inverter (CFI) Crystallizer." Separation and Purification Technology, June 2022, 121571. http://dx.doi.org/10.1016/j.seppur.2022.121571.

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26

Orehek, Jaka, Dušan Teslić, and Blaž Likozar. "Mechanistic Modeling of a Continuous Multi-Segment Multi-Addition Antisolvent Crystallization of Benzoic Acid in a Coiled Flow Inverter (Cfi) Crystallizer." SSRN Electronic Journal, 2022. http://dx.doi.org/10.2139/ssrn.4078700.

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