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Dissertations / Theses on the topic 'Antisense RNA'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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1

Tanniche, Imen. "Correlating antisense RNA performance with thermodynamic calculations." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/49698.

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Antisense RNA (asRNA) strategies are identified as an effective and specific method for gene down-regulation at the post-transcriptional level. In this study, the major purpose is to find a correlation between the expression level and minimum free energy to enable the design of specific asRNA fragments. The thermodynamics of asRNA and mRNA hybridization were computed based on the fluorescent protein reporter genes. Three different fluorescent proteins (i) green fluorescent protein (GFP), (ii) cyan fluorescent protein (CFP) and (iii) yellow fluorescent protein (YFP) were used as reporters. Each

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2

Denoeux, Stanislas. "Etude de la régulation de l'expression des gènes par un ARN antisens." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS167/document.

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Au cours de la dernière décennie, les avancées du séquençage à haut débit ont permis de caractériser un grand nombre d’ARN non codant et d’établir l’existence de transcrits “antisens” pour de nombreux gènes chez les mammifères. Cependant leur rôle dans le contrôle de l’expression des gènes “sens” auxquels ils sont associés est encore très mal connu. Mes travaux ont porté sur la caractérisation de certains aspects du mécanisme d’action des longs ARN non codants. Ils reposent sur le développement d’une approche de constructions indicatrices fluorescentes dont l’expression est suivie par cytométr

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3

Faridani, Omid Reza. "Studies on natural antisense RNAs and microRNAs /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-412-9/.

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4

Raponi, Mitch Biochemistry &amp Molecular Genetics UNSW. "Antisense RNA-mediated gene silencing in fission yeast." Awarded by:University of New South Wales. Biochemistry and Molecular Genetics, 2001. http://handle.unsw.edu.au/1959.4/18277.

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The major aims of this thesis were to investigate the influence of i) antisense gene location relative to the target gene locus (?????location effect?????), ii) double-stranded RNA (dsRNA) formation, and iii) over-expression of host-encoded proteins on antisense RNA-mediated gene regulation. To test the location effect hypothesis, strains were generated which contained the target lacZ gene at a fixed location and the antisense lacZ gene at various genomic locations including all arms of the three fission yeast chomosomes and in close proximity to the target gene locus. A long inverse-PCR proto

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5

Tan, Felicia. "Characterization of pilE antisense RNA in Neisseria meningitidis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:23d8f4c4-b423-4638-986b-b6b8e3fe95ec.

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Expression of Type four pili is important for colonization and virulence in Neisseria meningitidis, which is a major causative agent of bacterial meningitis and septicaemia. Pili mediate adhesion, twitching motility, DNA uptake, and can be subject to phase and antigenic variation (Av). Pilin expression and Av may be modulated in response to environmental cues; however, the mechanisms of regulation are still unclear. This work demonstrates the identification of a novel cis-encoded RNA on the antisense (AS) strand of pilE, which encodes the major pilin subunit. The AS promoter is conserved in di

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6

Mitrpant, Chalermchai. "Pre-mRNA splicing manipulation via Antisense Oligomers." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2009. https://ro.ecu.edu.au/theses/421.

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Duchenne muscular dystrophy (DMD), the most common lethal neuromuscular disease in childhood, arises from protein-truncating mutations in the dystrophin gene. A deficiency in dystrophin leads to loss of the dystrophin associated protein complex (DAPC), which in turn, renders muscle fibres vulnerable to injury, and eventually leads to muscle loss, necrosis and fibrosis. Although, the dystrophin gene was identified nearly two decades ago, and extensive research has been directed at finding a therapy for DMD, to date, there is still no effective treatment available. One promising molecular approa

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7

Reimegård, Johan. "Making Sense of Antisense." Doctoral thesis, Uppsala universitet, Mikrobiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131168.

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RNA is a highly versatile molecule with functions that span from being a messenger in the transfer from DNA to protein, a catalytic molecule important for key processes in the cell to a regulator of gene expression. The post-genomic era and the use of new techniques to sequence RNAs have dramatically increased the number of regulatory RNAs during the last decade. Many of these are antisense RNAs, as for example the miRNA in eukaryotes and most sRNAs in bacteria. Antisense RNAs bind to specific targets by basepairing and thereby regulate their expression. A major step towards an understanding o

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8

Chadwick, D. R. "Studies on antisense RNA inhibition of HIV-1 replication." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597386.

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Two vector systems were developed expressing antisense RNA (of two different sizes) complementary to three target regions in the 5' leader/LTR of HIV-1: the R (TAR) region, the primer binding site and the splice donor-packaging signal (ψ) region. After cloning these regions into an expression vector, <I>pcDNA3, </I>designed to express these sequences at high levels from the CMV IE promoter, stable constitutive expression in a T cell line was demonstrated by RT-PCR. After directly challenging these cell lines with HIV-1 at various doses cell lines expressing antisense RNA targeting the ψ-region

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9

Engdahl, Hilde Merete. "Natural and artificial antisense RNA : a study of inhibition of gene expression /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2000. http://epsilon.slu.se/avh/2000/91-576-5784-X.pdf.

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10

Dong, Shuzhi Dong Shuzhi. "I. Restriction of DNA conformation by spirocyclic annulation at C-4' II. Studies toward the enantioselective synthesis of pestalotiopsin A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174627553.

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11

Barman, Jharna. "Targeting RNA by the Antisense Approach and a Close Look at RNA Cleavage Reaction." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8272.

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12

Wright, Jordan. "Capsule Thermoregulation and Non-Coding RNA in Streptococcus pyogenes." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1505.

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Streptococcus pyogenes is a re-emerging pathogen that produces superficial and life threatening invasive diseases. One important virulence factor in S. pyogenes is hyaluronic acid capsule which has been shown to increase expression at sub-body temperatures in certain strains. This study showed that thermoregulation is common in invasive clinical isolates. Regulation was shown to occur independent of the CovRS two-component regulator in a post transcription manner and before protein level regulation. The endoribonuclease, CvfA, was also confirmed to be required for capsule thermoregulation.

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13

Chalk, Alistair. "Computational prediction of antisense oligonucleotides and siRNAs /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-376-0/.

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14

Dixon, Maria S. "ANTISENSE AFP TRANSCRIPTS IN MOUSE LIVER AND THEIR POTENTIAL ROLE IN AFP GENE REGULATION." UKnowledge, 2017. http://uknowledge.uky.edu/microbio_etds/14.

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Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, ranking the sixth most common cancer and third most common cause of cancer mortality worldwide. Alpha-fetoprotein (AFP) is a plasma protein that is highly expressed in the fetal liver and shut off after birth. AFP expression is elevated in regenerating adult liver and HCC and has been used extensively as a diagnostic marker of liver cancer. We have been studying mouse liver gene regulation to better understand mechanisms by which changes in gene expression contribute to liver development, homeostasis and disease. Z

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15

Udekwu, Klas Ifeanyi. "Functional characterization of the small antisense RNA MicA in Escherichia coli." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7759.

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16

Åström, Hans. "Studies on phosphate ester cleavage and development of oligonucleotide based artificial nucleases (OBAN's) /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-935-8/.

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17

Li, Jing. "Targeted degradation of RNA by RNase H using stable DNA hairpin oligomers and a study on the effect of temperature and divalent cations on RNA conformational states." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/25213.

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18

Peters, Nick T. "RNA EDITING AND REGULATION OF DROSOPHILA 4f-rnp EXPRESSION BY sas-10 ANTISENSE READTHROUGH mRNA TRANSCRIPTS." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1059663673.

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19

Carter, Karen Kimberly. "Using antisense messenger RNA to downregulate lon mediated proteolysis in escherichia coli." College Park, Md. : University of Maryland, 2003. http://hdl.handle.net/1903/108.

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Thesis (M.S.) -- University of Maryland, College Park, 2003.<br>Thesis research directed by: Dept. of Chemical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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20

Pereira, Carlos de Ocesano. "INXS, um longo RNA não codificador de proteínas mediador da apoptose." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-20072015-144251/.

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O splicing alternativo do pré-mRNA de BCL-X produz duas isoformas de mRNAs com funções antagônicas, a pró-apoptótica BCL-XS e a anti-apoptótica BCL-XL, cujo balanço regula a homeostasia celular. Entretanto, o mecanismo que regula esse processamento ainda é desconhecido. Nesse trabalho, nós identificamos e caracterizamos um longo RNA não codificador de proteínas (lncRNA) nomeado INXS, que é transcrito a partir da fita oposta do locus genômico de BCL-X, sendo menos abundante em linhagens celulares tumorais e tecidos tumorais de pacientes quando comparados com os respectivos pares não tumorais. I

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21

Pandey, Radha Raman. "Molecular Insights into Kcnq1ot1 Noncoding Antisense RNA Mediated Long Range Transcriptional Gene Silencing." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9392.

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22

Almeida, João Paulo Pereira de. "O transcritoma antisense primário de Halobacterium salinarum NRC-1." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-15012019-101127/.

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Em procariotos, RNAs antisense (asRNAs) constituem a classe de RNAs não codificantes (ncRNAs) mais numerosa detectada por métodos de avaliação de transcritoma em larga escala. Apesar da grande abundância, pouco se sabe sobre mecanismos regulatórios e aspectos da conservação evolutiva dessas moléculas, principalmente em arquéias, onde o mecanismo de degradação de RNAs dupla fita (dsRNAs) é um fenômeno pouco conhecido. No presente estudo, utilizando dados de dRNA-seq, identificamos 1626 inícios de transcrição primários antisense (aTSSs) no genoma de Halobacterium salinarum NRC-1, importante orga

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23

Rouleau, Samuel. "Oligonucléotides comme modulateurs de l'expression génique." Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11570.

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L’ARN est sans aucun doute la molécule biologique la plus versatile qui soit. Tout comme l’ADN, il peut contenir et transmettre de l’information génétique. Tout comme les protéines, il peut accomplir une multitude de fonctions biologiques. De plus, son rôle le plus connu demeure celui d’intermédiaire entre l’ADN et les protéines. L’ARN est donc au cœur d’un bon nombre de processus biologiques. Ceci lui confère un immense potentiel thérapeutique qui jusqu’à présent demeure largement inexploité. Pour accomplir ses fonctions, l’ARN doit adopter une structure tridimensionnelle précise qui est dépe

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24

Lehmann, Thomas. "Synthese, Eigenschaften und Anwendung Gallensäure derivatisierter Antisense-Oligonukleotide gegen Hepatitis-C-Virus RNA." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963895567.

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25

Day, Anthony George. "Suppression of viral and endogenous gene expression in N. tabacum using antisense RNA." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46277.

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26

Murray, Robert John Stuart. "Investigation of a developmentally linked transcriptional gene silencing mechanism involving an antisense RNA." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/9939.

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An increasing number of RNA targeted gene repression mechanisms are being discovered operating in mammalian cells. Antisense-RNA mediated silencing of CpG island-associated genes is not limited to imprinting and X inactivation, but can occur at autosomal non-imprinted loci leading to disease. An antisense silencing phenomenon observed in a patient with an inherited form of anaemia was recently recreated in differentiating mouse embryonic stem cells, demonstrating that the silencing and methylation of the oppositely transcribed tissue specific alpha globin CpG island exclusively occurs in the p

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27

Tordo, J. "Vectors for therapeutic antisense sequences delivery and the modification of messenger RNA processing." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383711/.

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Synthetic antisense oligoribonucleotides can be used to modulate gene splicing by masking key motifs on the pre-mRNA required for spliceosome assembly. Yet, intracellular expression of oligoribonucleotides generates only a transitory effect whereas stable delivery of antisense sequences can be achieved by linking them to chimeric small RNAs delivered and expressed by viral vectors. In the murine model of Duchenne Muscular Dystrophy a chimeric U7 snRNA (U7Dtex23) induces skipping of the mutated exon 23 and restores the Dystrophin mRNA reading frame. The main limitation of this approach remains

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28

Merkle, Tobias [Verfasser]. "Engineering Antisense Oligonucleotides for Site-directed RNA Editing with Endogenous ADAR / Tobias Merkle." Tübingen : Universitätsbibliothek Tübingen, 2022. http://d-nb.info/1237684390/34.

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29

Wu, Wen-Jun. "Creation of a Vector for Regulated Expression of Antisense RNA in Escherichia Coli." TopSCHOLAR®, 1992. https://digitalcommons.wku.edu/theses/3003.

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A plasmid (pGEM-SD) was constructed in which the Shine-Dalgarno sequence had been deleted from pGEM-7zf(+) plasmid to generate a vector for regulated expression of antisense RNA. The binding of antisense RNA to mRNA provides a potent mechanism by which specific transcripts can be translationally inactivated. Although part of the lac operator sequence was deleted in pGEM-SD plasmid, it was proven that mRNA still can be induced under the control of lac promoter. Recombinant plasmids were generated by ligating bacterial genornic DNA into pGEM-SD plasmid, but the orientation of the inserted gene w

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30

Li, Qing. "Conformationally Constrained Oligonucleotides for RNA Targeting." Doctoral thesis, Uppsala universitet, Kemisk biologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179069.

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A short oligonucleotide sequence as in a single-stranded antisense oligo nucleotides (AON) or in double-stranded small interfering RNAs (siRNA) can modulate the gene expression by targeting against the cellular mRNA, which can be potentially exploited for therapeutic purposes in the treatment of different diseases. In order to improve the efficacy of oligonucleotide-based drugs, the problem of target affinity, nuclease stability and delivery needs to be addressed. Chemical modifications of oligonucleotides have been proved to be an effective strategy to counter some of these problems. In this

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31

Giaretta, Laura. "T7-CYANO - Production and development of a Synechocystis strain useful for inducible membrane protein expression and controlled antisense RNA synthesis." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423962.

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Cyanobacteria are supposed to have been the first organisms able to evolve oxygen by photosynthesis, the process that uses solar light as energy source to fix CO2 into carbohydrate molecules. Historically, they have been and are a model system for studying fundamental processes including and relating to photosynthesis. In more recent years cyanobacteria acquired interest also in biotechnology, in particular as an alternative energy resource, for instance in ethanol or hydrogen production, and as a source for the production of molecules useful in the pharmaceutical industry. Moreover cyanobacte

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32

Black, E. J. "Studies on the use of antisense RNA to control gene expression in Nicotiana tabacum." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/38236.

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33

Yang, Zhiyi. "Maize 18 kDa heat shock gene expression revealed by antisense RNA in situ hybridization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq21117.pdf.

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34

Turgut, Kenan. "A study of anther gene function in Brassica napus using an antisense RNA approach." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35360.

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35

Carrieri, Claudia. "UCHL1 protein synthesis upon rapamycin treatment involves its antisense RNA trough embedded SINEB2 repeat." Doctoral thesis, SISSA, 2011. http://hdl.handle.net/20.500.11767/4126.

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The initial description of genomes organization has consisted in the separation between regulatory and protein-coding DNA stretches. This simple and elegant model has supported the “one region-one function” theory: a genome is a linear arrangement of functional elements interspersed with nonfunctional regions. Recently the advances in transcriptomics technologies have shown that a genomic region can be used for different purposes and that functional elements can co-locate in the same region of the genome.

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36

Mikaeili, Hajar. "Investigating the role of FXN antisense transcript 1 in Friedreich ataxia." Thesis, Brunel University, 2017. http://bura.brunel.ac.uk/handle/2438/16496.

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Friedreich ataxia (FRDA) is a neurodegenerative disorder that is inherited in an autosomal recessive pattern. The most common FRDA mutation is hyperexpansion of a GAA triplet repeat sequence in the first intron of the affected gene, frataxin (FXN), resulting in decreased frataxin protein expression. The hyperexpanded GAA repeats can adopt unusual DNA structures and induce aberrant epigenetic changes leading to heterochromatin mediated gene silencing. Several epigenetic changes, including increased levels of DNA methylation, histone modifications, repressive chromatin formation and elevated lev

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37

Broadbent, Kate Mariel. "The regulatory capacity of long non-coding RNA in Plasmodium falciparum malaria." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065005.

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The mechanisms underpinning gene regulation in P. falciparum malaria remain largely elusive, though mounting evidence suggests a major role for epigenetic feedback. Interestingly, long non-(protein)-coding RNAs (lncRNAs) have been found to play a dominant role in initiating and guiding the transcriptional, epigenetic, and post-transcriptional status of specific loci across a broad range of organisms. LncRNAs are uniquely poised to act co-transcriptionally on neighboring loci, and/or to remain physically tethered at their site of origin, and through sequence-specific binding activities can impa

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38

Lu, Chungui. "The role of a ripening-induced Rab11a GTPase in tomato (Lycopersicon esculentum Mill.) development." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310948.

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39

Slagter-Jäger, Jacoba G. "CopA and CopT: The Perfect RNA Couple." Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3465.

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<p>Antisense RNAs regulate gene expression in many bacterial systems. The best characterized examples are from prokaryotic accessory elements such as phages, plasmids and transposons. Many of these antisense RNAs have been identified as plasmid copy number regulators where they regulate the replication frequency of the plasmid by negative feedback. Instability and fast binding kinetics is crucial for the regulatory efficiency of these antisense RNAs. </p><p>In this thesis, the interaction of the cis-encoded antisense RNA CopA with its target CopT was studied in detail using <i>in vivo</i> repo

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40

Aparicio, i. Prat Estel. "Natural antisense transcripts control LEF1 gene expression." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/299211.

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Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT is transcribed from a promoter present in the first LEF1 intron and undergoes splicing in mesenchymal cells. In epithelial cells, there is no expression of LEF1 NAT. However, in metastable epithelial cells, LEF1 NAT is transcribed and a significant part of it remains unspliced and, contrarily to the spliced NAT, down-regulates the main LEF1 promoter and LEF1 mRNA and protein expression. Moreo

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41

Cimatti, Laura. "Long Non-Coding RNA Antisense to Uchl1 Increases Its Protein Translation and Identifies a New Class of Protein Translation Activators." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/3922.

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Thanks to continuous technical advances in the sequencing field nowadays we know that most of the mammalian genome is transcribed. This generates a vast repertoire of transcripts that includes protein-coding messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs) and repetitive sequences, such as Short Interspersed Nuclear Elements (SINEs). A large percentage of ncRNAs is nuclear-enriched with unknown function. LncRNAs may be transcribed in antisense direction and may form sense/antisense pairs by pairing with an mRNA from the opposite strand to regulate chromatin conformation, transcription an

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42

Baughan, Travis Lorson Christian. "Gene therapy in spinal muscular atrophy RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6686.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on March 10, 2010). Vita. Thesis advisor: Lorson, Christian L. "December 2008" Includes bibliographical references

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43

Rhodes, Andrew D. "An investigation into the use of antisense RNA for the control of human immunodeficiency virus replication." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303662.

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44

Reuscher, Carina Maria [Verfasser]. "Posttranskriptionelle Regulation bakterieller Photosynthesegene durch die Ribonuklease E und die antisense RNA asPcrL / Carina Maria Reuscher." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1224970659/34.

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Reuscher, Carina [Verfasser]. "Posttranskriptionelle Regulation bakterieller Photosynthesegene durch die Ribonuklease E und die antisense RNA asPcrL / Carina Maria Reuscher." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1224970659/34.

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46

Navickas, Albertas. "Cytoplasmic control of sense-antisense mRNA pairs in Saccharomyces cerevisiae." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066381/document.

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Les récentes études transcriptomiques chez divers organismes ont montré que la transcription des gènes convergents peut produire des ARN messagers (ARNm) chevauchants. Ce phénomène a été analysé dans le contexte de l’interférence par ARN (ARNi) nucléaire, et peu d’information existe quant au destin cytoplasmique des messagers 3’ chevauchants ou leur impact sur l’expression des gènes. Dans ce travail, nous avons abordé les conséquences potentielles de l’interaction entre des paires d’ARNm sens-antisens chez Saccharomyces cerevisiae, un organisme modèle naturellement dépourvu de l’ARNi. Nous avo

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47

Navickas, Albertas. "Cytoplasmic control of sense-antisense mRNA pairs in Saccharomyces cerevisiae." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066381.pdf.

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Les récentes études transcriptomiques chez divers organismes ont montré que la transcription des gènes convergents peut produire des ARN messagers (ARNm) chevauchants. Ce phénomène a été analysé dans le contexte de l’interférence par ARN (ARNi) nucléaire, et peu d’information existe quant au destin cytoplasmique des messagers 3’ chevauchants ou leur impact sur l’expression des gènes. Dans ce travail, nous avons abordé les conséquences potentielles de l’interaction entre des paires d’ARNm sens-antisens chez Saccharomyces cerevisiae, un organisme modèle naturellement dépourvu de l’ARNi. Nous avo

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48

Fischer, Tom. "Charakterisierung des dopaminergen Systems bei transgenen Ratten mit einem Antisensekonstrukt gegen die m-RNA der Tryptophanhydroxylase." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969655371.

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49

Voigtsberger, Stefanie. "Untersuchungen zur Expression natürlicher Antisense RNA von kardialem Troponin I in neonatalen Kardiomyozyten und Fibroblasten der Ratte /." Berlin, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253704.

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Chevassut, Timothy J. T. "Characterisation of two methods involving double-stranded RNA for the functional genetic analysis of the murine embryonic stem cell : antisense gene trapping & RNA interference." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24398.

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Abstract:

Murine embryonic stem cells are derived from the inner cell mass of a pre-implantation mouse blastocyst. These cells exhibit dual defining characteristics of indefinite self-renewal and pluripotent differentiation. This thesis sought to explore two different methods of functional genetic analysis of embryonic stem cells, namely antisense gene trapping and RNA interference. Antisense gene trapping in embryonic stem cells involves the sequential genomic integration of two vectors: the first to randomly trap active gene promoters and the second to induce functional antisense gene knockout. Clones

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